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Chemical Structure| 305-53-3 Chemical Structure| 305-53-3

Structure of Sodium iodoacetate
CAS No.: 305-53-3

Chemical Structure| 305-53-3

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Product Citations

Product Citations

Al-Uqabi ; Rabab Utba ; Al-Gareeb ; Ali I. ; Al-Buhadily ; Ali K.

Abstract: Background: Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet. Aims: To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA. Methods: A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00. Results: group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group. Conclusion: Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.

Keywords: Celecoxib ; CTX-II ; osteoarthritis

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Product Details of [ 305-53-3 ]

CAS No. :305-53-3
Formula : C2H2INaO2
M.W : 207.93
SMILES Code : O=C([O-])CI.[Na+]
MDL No. :MFCD00002686
InChI Key :AGDSCTQQXMDDCV-UHFFFAOYSA-M
Pubchem ID :5239

Safety of [ 305-53-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H314
Precautionary Statements:P260-P264-P270-P280-P301+P310+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of [ 305-53-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 305-53-3 ]

[ 305-53-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 305-53-3 ]
  • [ 139115-91-6 ]
  • [ 108466-89-3 ]
  • 2
  • [ 305-53-3 ]
  • [ 889952-83-4 ]
YieldReaction ConditionsOperation in experiment
Preparation 17; S-Carboxymethoxyazetidine-l-carboxylic acid tert-butyl ester; Anhydrous DMF (5 mL) was added slowly to a stirred mixture of 3-hydroxyazetidine-l- carboxylic acid tert-butyl ester (350 mg, 2.0 mmol) and NaH (121 mg of a 60% dispersion in mineral oil, 3.0 mmol) at 00C. After 15 min, ICH2CO2Na (630 mg, 3.0 mmol) was added, then stirring was continued at 200C for 65 h. The solvent was removed in vacuo, then the residue was partitioned between H2O (15 mL) and EtOAc (10 mL). The organic phase was extracted with saturated aqueous Na2CO3 (2 x 10 mL), then the combined aqueous extracts were acidified to pH 2 with 2 M HCl, before being extracted with EtOAc (2 x 50 mL). The EtOAc extracts were washed with brine, before being dried (MgSO4). Filtration, solvent evaporation, and column chromatography (IH-EtOAc, 1:1) furnished the title compound
  • 3
  • [ 99-89-8 ]
  • [ 305-53-3 ]
  • [ 1643-16-9 ]
 

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Related Functional Groups of
[ 305-53-3 ]

Iodides

Chemical Structure| 64-69-7

A488062 [64-69-7]

2-Iodoacetic acid

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