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Chemical Structure| 321405-31-6 Chemical Structure| 321405-31-6

Structure of 321405-31-6

Chemical Structure| 321405-31-6

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Product Details of [ 321405-31-6 ]

CAS No. :321405-31-6
Formula : C11H10N2O
M.W : 186.21
SMILES Code : O=CC1=NN(CC2=CC=CC=C2)C=C1
MDL No. :MFCD20483770

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 321405-31-6 ]

[ 321405-31-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 321405-31-6 ]
  • [ 63558-65-6 ]
  • (1-benzyl-1H-pyrazol-3-yl)(4-chloropyrimidin-5-yl)methanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% Step 1: (l-BenzyI-lH-pyrazol-3-yl)(4-chloropyrimidin-5-yl)methanol 4-Chloro-5-iodopyrimidine (300 mg, 1.25 mmol) was weighed into a 100 mL 2 necked RBF and the flask was purged with argon. This starting material was dissolved in THF (10 mL) and the solution was cooled to -78 C. To the solution was added n-Butyllithium (2.50 M in hexane; 1.0 mL, 2.5 mmol) at -78 C and then the mixture was stirred for 30 min. To this mixture was added dropwise a solution of 1 -benzyl- lH-pyrazole-3-carbaldehyde (211 mg, 1.1 mmol) in THF (4 mL), and the resulting mixture was stirred for 30 min. The reaction was quenched by addition of saturated NH4CI (50 mL) and extracted with EtOAc (50 mLx4). The combined organic layers were washed with brine, dried over Na2S04, filtered, and concentrated in vacuo. The residue was purified on silica gel to provide (1-benzyl- lH-pyrazol-3-yl)(4-chloropyrimidin-5-yl)methanol (304 mg, 85%) as a light yellow oil. LCMS (FA): m/z = 301.4 (M+H).
 

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