Alternatived Products of [ 35582-08-2 ]
Product Details of [ 35582-08-2 ]
CAS No. : | 35582-08-2 |
MDL No. : | MFCD14657178 |
Formula : |
C9H8N2O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
160.17
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 35582-08-2 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 35582-08-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 35582-08-2 ]
- 1
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[ 63558-65-6 ]
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[ 35582-08-2 ]
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(5-iodo-pyrimidin-4-yl)-(3-oxazol-2-yl-phenyl)-amine
[ No CAS ]
- 2
-
[ 26452-80-2 ]
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[ 35582-08-2 ]
-
4-chloro-N-(3-oxazol-2-ylphenyl)pyridin-2-amine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
62% |
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 0.5h; Microwave irradiation; Inert atmosphere; Sealed tube; regioselective reaction; |
4-chloro-N-phenyl-pyridin-2-amine (3a)
General procedure: Aniline (62μl, 0.68 mmol), 2,4-dichloropyridine (100 mg, 0.68 mmol), cesium carbonate (442 mg, 1.36 mmol), xantphos (47 mg, 0.08 mmol) and Pd(OAc)2 (12 mg, 0.05 mmol) were combined in a microwave tube, sealed and purged with nitrogen. Dioxane (3 mL) was then added and the reaction solution degassed with nitrogen prior to heating at 100°C for 30 minutes. The reaction mixture was then filtered and the filtrate was purified by reverse phase chromatography, utilizing a 20-65% gradient over 9 mins, with 0.5% ammonia as modifier to afford 4-chloro-N-phenyl-pyridin-2-amine |
Reference:
[1]Burton, Rebecca J.; Crowther, Mandy L.; Fazakerley, Neal M.; Fillery, Shaun M.; Hayter, Barry M.; Kettle, Jason G.; McMillan, Caroline A.; Perkins, Paula; Robins, Peter; Smith, Peter M.; Williams, Emma J.; Wrigley, Gail L.
[Tetrahedron Letters, 2013, vol. 54, # 50, p. 6900 - 6904]