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[ CAS No. 39562-22-6 ] {[proInfo.proName]}

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Chemical Structure| 39562-22-6
Chemical Structure| 39562-22-6
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Product Details of [ 39562-22-6 ]

CAS No. :39562-22-6 MDL No. :MFCD00521048
Formula : C14H15NO6 Boiling Point : -
Linear Structure Formula :- InChI Key :UVZJPCAZMGLNTB-UKTHLTGXSA-N
M.W : 293.27 Pubchem ID :2063485
Synonyms :

Safety of [ 39562-22-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 39562-22-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 39562-22-6 ]
  • Downstream synthetic route of [ 39562-22-6 ]

[ 39562-22-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 40100-28-5 ]
  • [ 39562-22-6 ]
  • [ 66085-59-4 ]
Reference: [1] Arzneimittel-Forschung/Drug Research, 1983, vol. 33, # 1, p. 106 - 112
  • 2
  • [ 39562-22-6 ]
  • [ 132203-70-4 ]
YieldReaction ConditionsOperation in experiment
91.5%
Stage #1: for 1 h; Reflux
Stage #2: With hydrogenchloride In ethanol; water for 1 h; Reflux
1. In a 250 ml bottle, added material a: 2-(3-nitrophenylmethylene)acetoacetic acid methyl ester (54g, 0.184mol) and material b:3-amino-2-butenoic acid cinnamyl ester (40g, 0.184mol) and anhydrous ethanol (80g), heating reflux 1 hour; 2. To step 1 added concentrated hydrochloric acid to the reaction system (> 35percent) 3.31 ml, continue to reflux for 1 hour, the rear cooling crystallization, filtering to obtain cilnidipine crude; thick quantity : 80.7g; yield 88.98percent ; M.P.: 106.1-106.7 °C; maximum shan Za : 0.2percent, a total of 10 small impurity peak, content: 99.25percent.Receiving product: 80.77gYield 89.07percent,M.P.: 106.0-106.8 °CThe maximum shan Za : 0.29percentA total of 9 small impurity peakContent: 99.18percent 3. In accordance with the weight ratio of ethanol: crude = 3:1 use anhydrous ethanol is added in the amount in step 2 the horizontal thick Sydney obtained in recrystallization, to get finished product Cini the horizontal.Yield 91.5percent,M.P.: 107.4-108.2 °CThe maximum shan Za : 0.1460percentThe minimum shan Za : 0.0502percentA total of 2 a small impurity peakContent: 99.8percent
Reference: [1] Patent: CN105384682, 2016, A, . Location in patent: Paragraph 0084-0100
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