[ CAS No. 39643-31-7 ] {[proInfo.proName]}

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Quality Control of [ 39643-31-7 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 39643-31-7 ]

Product Details of [ 39643-31-7 ]

CAS No. :	39643-31-7	MDL No. :	MFCD00047467
Formula :	C₁₁H₁₆N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OYECAJPUPWFCSL-UHFFFAOYSA-N
M.W :	176.26	Pubchem ID :	458795
Synonyms :

Safety of [ 39643-31-7 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501	UN#:	2811
Hazard Statements:	H301-H311-H331	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 39643-31-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 39643-31-7 ]

[ 39643-31-7 ] Synthesis Path-Downstream 1~11

1
[ 39643-31-7 ]
[ 1488-42-2 ]
[ 1027049-76-8 ]

Yield	Reaction Conditions	Operation in experiment
	With copper diacetate In isopropyl alcohol at 85℃; for 23h;

Reference： [1]Liu, Gang; Szczepankiewicz, Bruce G.; Pei, Zhonghua; Janowick, David A.; Xin, Zhili; Hajduk, Philip J.; Abad-Zapatero, Cele; Liang, Heng; Hutchins, Charles W.; Fesik, Stephen W.; Ballaron, Steve J.; Stashko, Mike A.; Lubben, Tom; Mika, Amanda K.; Zinker, Bradley A.; Trevillyan, James M.; Jirousek, Michael R. [Journal of Medicinal Chemistry, 2003, vol. 46, # 11, p. 2093 - 2103]

2
[ 13529-17-4 ]
[ 39643-31-7 ]
5-formyl-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	Stage #1: 5-Formyl-2-furancarboxylic acid; 2-piperidin-1-yl-phenylamine With benzotriazol-1-ol; triethylamine In dichloromethane at 20℃; for 0.166667h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane	4.A EXAMPLE 4-A; 5-(2-PIPERIDIN-L-YL-PHENYLCARBAMOYL)-FURAN-2-CARBOXYLIC acid A solution OF 5-FORMYL-2-FURANCARBOXYLIC acid (TCI) (1.0 mmol), 2- piperidinoaniline (1.0 mmol), HOBT (1.2 mmol), and Et3N (2 mmol) in DCM (10 mL) was stirred for 10 min at room temperature. EDCI (1.2 mmol) was then added and the resulting orange solution was stirred overnight. The reaction mixture was treated with saturated NAHC03 solution (10 mL) and extracted with DCM. The combined organic layers were dried over MGS04, and concentrated under reduced pressure to afford the crude product as an orange solid. Purification by silica gel chromatography afforded the amidoaldehyde product in 80 % yield. The aldehyde product (1 mmol) was dissolved IN H20/DIMETHOXYETHANE ("DME") (2: 1,5 mL) containing sodium carbonate ("NA2C03") (2 mol). In a separate flask, potassium permanganate ("KMNO4") (1.3 mmol) was dissolved in HA0 (5 mL) and was slowly added to the reaction flask at 45 °C. The reaction was stirred overnight at room temperature, filtered through a plug of celite, and then acidified to a pH of 3 to 4 using a hydrochloric acid ("HC1") solution (1 N). The product, which precipitated out as a white solid, was filtered, washed with H2O and dried under high vacuum to afford pure product. MS: 315 (M+1). 1H NMR (DMSO-D6, 300 MHZ) : 8 13. 60 (br s, 1H), 9.90 (s, 1H), 8.25 (dd, 1H), 7.36 (dd, 2H), 7.35-7. 25 (m, 1H), 7.20-7. 10 (m, 2H), 2.85-2. 65 (m, 4H), 1.85-1. 65 (m, 4H), 1.65-1. 45 (m, 2H).
80%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;	4-A EXAMPLE 4-A; 5-(2-Piperidin-l-yl-phenylcarbamoyl)-furan-2-carboxvlic acid; A solution of 5-formyl-2-furancarboxylic acid (TCI) (1.0 mmol), 2-piperidinoaniline (1.0 mmol), HOBT (1.2 mmol), and Et3N (2 mmol) in DCM (10 mL) was stirred for 10 min at room i temperature. EDCI (1.2 mmol) was then added and the resulting orange solution was stirred Overnight. The reaction mixture was treated with saturated NaHCO3 solution (10 mL) and extracted with DCM. The combined organic layers were dried over MgSO4, and concentrated under reduced pressure to afford the crude product as an orange solid. Purification by silica gel chromatography afforded the amidoaldehyde product in 80 % yield. The aldehyde product (1 mmol) was dissolved in H2θ/dimethoxyethane ("DME") (2:1, 5 mL) containing sodium carbonate ("Na2CO3") (2 mol). In a separate flask, potassium permanganate ("KMnO4") (1.3 mmol) was dissolved in H2O (5 mL) and was slowly added to the reaction flask at 45 0C. The reaction was stirred overnight at room temperature, filtered through a plug of celite, and then acidified to a pH of 3 to 4 using a hydrochloric acid ("HCl") solution (1 N). The product, which precipitated out as a white solid, was filtered, washed with H2O and dried under high vacuum to afford pure product. MS: 315 (M+l). 1H NMR (DMSO^65 SOO MHZ): δ 13.60 (br s, IH), 9.90 (s, IH), 8.25 (dd, IH), 7.36 (dd, 2H), 7.35-7.25 (m, IH), 7.20-7.10 (m, 2H), 2.85-2.65 (m, 4H), 1.85-1.65 (m, 4H), 1.65-1.45 (m, 2H).

Reference： [1]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2004/96795, 2004, A2 Location in patent: Page 24-25
[2]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2007/123516, 2007, A1 Location in patent: Page/Page column 32-33

3
[ 400743-82-0 ]
[ 20012-63-9 ]
[ 39643-31-7 ]
[ 728918-72-7 ]
C₈H₇F₄N [ No CAS ]
C₃₃H₂₉IN₅O₄Pol [ No CAS ]
[ 91646-45-6 ]
[ 4273-98-7 ]
[ 2264-92-8 ]
[ 1204-44-0 ]
[ 68817-71-0 ]
[ 369-36-8 ]
[ 37750-29-1 ]
[ 55751-54-7 ]
[ 18595-14-7 ]
[ 52562-19-3 ]
[ 62532-99-4 ]
[ 21627-58-7 ]
[ 73818-73-2 ]
[ 54705-91-8 ]
[ 26286-54-4 ]
[ 177171-13-0 ]
[ 99-55-8 ]
[ 23491-48-7 ]
[ 400750-84-7 ]
C₄₂H₃₇N₈O₄Pol [ No CAS ]
C₄₂H₃₇N₈O₄Pol [ No CAS ]
C₄₃H₄₃N₆O₄Pol [ No CAS ]
C₄₂H₃₉N₆O₄Pol [ No CAS ]
C₄₃H₃₇N₆O₄PolS [ No CAS ]
C₄₀H₃₆N₇O₆Pol [ No CAS ]
C₄₂H₃₉N₆O₆Pol [ No CAS ]
C₃₉H₃₃FN₇O₆Pol [ No CAS ]
C₄₄H₃₉N₆O₅Pol [ No CAS ]
C₄₅H₃₈ClN₆O₄Pol [ No CAS ]
C₄₆H₄₁N₆O₄Pol [ No CAS ]
C₄₃H₄₂N₇O₄Pol [ No CAS ]
C₄₆H₄₁N₆O₅Pol [ No CAS ]
C₄₅H₃₈FN₆O₄Pol [ No CAS ]
C₄₅H₃₈ClN₆O₄Pol [ No CAS ]
C₄₁H₃₅F₄N₆O₄Pol [ No CAS ]
C₄₅H₃₉N₆O₆PolS [ No CAS ]
C₄₅H₃₈ClN₆O₄PolS [ No CAS ]
C₄₄H₄₄N₇O₄Pol [ No CAS ]
C₄₇H₄₁N₆O₅Pol [ No CAS ]
C₄₅H₃₉ClN₇O₄Pol [ No CAS ]
C₄₇H₄₁N₆O₆Pol [ No CAS ]
C₄₅H₄₅N₈O₅Pol [ No CAS ]
C₄₄H₄₄N₉O₆Pol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate;palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ISOPROPYLAMIDE; at 60℃;Combinatorial reaction / High throughput screening (HTS);	Step 2. Catalytic amination of the solid supported 8-iodo-l-methyl-4,5-dihydro- lH-pyrazolo [4,3-h] quinazoline-3-carboxamide; <n="82"/>Using a 4 niL Argonaut Trident synthesizer cassette, 200 mg (0.11 mmol) of the resin from step 1 above, were charged into separate vials. To each of the reactor vials flushed with argon, finely divided potassium carbonate (0.15 g, 1.1 mmol), palladium acetate [Pd(OAc)2] (2.5mg, 0.011 mmol, 10%), (HK)-BINAP (6.8 mg, 0.011 mmol, 10%) and the corresponding amine (0.22 mmol, 2 equivalents) in degassed (argon) dimethyacetamide (2 mL) were added. The resulting mixture was agitated at 600C for 10 hours on the Argonaut Trident Automated Library Synthesizer (ALS) station. The Trident ALS station was programmed to continuously mechanically agitate the resin at 6O0C while a nitrogen gas "sparge" was incorporated to re-suspend the scarcely soluble potassium carbonate. Nitrogen gas sparging was incorporated once per hour, for a 30 second duration, throughout the 16-hour heating cycle.The resin was drained from the synthesis cocktail and washed using the Argonaut Trident External Agitation Thermal Unit (EATU) synthesis station with DMA (3 x 2 mL, 5 min.). The above catalytic amination cycle was repeated a second time using the previously described procedure.Upon completion of the second amination cycle, the resin was drained from the synthesis cocktail and washed using the Argonaut Trident EATU synthesis station with DMF (1 x 2 mL, 5 min.), with water (1 x 2 mL, 5 min.), with DMF/water (1 : 1) (3 x 2 mL, 5 min.), with DMF (3 x 2 mL, 5 min.), with methanol (3 x 2 mL, 5 min.) and with DCM (3 x 2 mL, 5 min.).

Reference： [1]Patent: WO2008/74788,2008,A1 .Location in patent: Page/Page column 80-81

4
[ 50602-38-5 ]
[ 39643-31-7 ]
[ 1100345-25-2 ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-ol; 1,2-dichloro-ethane In 1-methyl-pyrrolidin-2-one for 48h;

Reference： [1]Burger, Matthew T.; Han, Wooseok; Lan, Jiong; Nishiguchi, Gisele; Bellamacina, Cornelia; Lindval, Mika; Atallah, Gordana; Ding, Yu; Mathur, Michelle; Mcbride, Chris; Beans, Elizabeth L.; Muller, Kristine; Tamez, Victoriano; Zhang, Yanchen; Huh, Kay; Feucht, Paul; Zavorotinskaya, Tatiana; Dai, Yumin; Holash, Jocelyn; Castillo, Joseph; Langowski, John; Wang, Yingyun; Chen, Min Y.; Garcia, Pablo D. [ACS Medicinal Chemistry Letters, 2013, vol. 4, # 12, p. 1193 - 1197]

5
[ 3973-08-8 ]
[ 39643-31-7 ]
[ 1458537-35-3 ]

Reference： [1]ACS Medicinal Chemistry Letters,2013,vol. 4,p. 1193 - 1197

6
[ 16042-25-4 ]
[ 39643-31-7 ]
[ 1469925-02-7 ]

Reference： [1]ACS Medicinal Chemistry Letters,2013,vol. 4,p. 1193 - 1197

7
[ 49609-84-9 ]
[ 39643-31-7 ]
2-chloro-N-(2-(piperidin-1-yl)phenyl)nicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: 2-piperidin-1-yl-phenylamine With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 2-Chloronicotinoyl chloride In dichloromethane for 0.5h;	3.2.3. Synthesis of Compounds III: 2-Chloro-N-(2-(piperidin-1-yl)phenyl)nicotinamide (1b) A solution of 2-(piperidin-1-yl)aniline (0.2 g, 0.025 mol), dichloromethane (25 mL) and triethylamine (0.5 mL) was added to a 50 mL flask and cooled to 0 °C in an ice bath. After ten minutes, 2-chloronicotinoyl chloride (0.22 g) was added [20,21]. The mixture was stirred for 30 min, and then concentrated under reduced pressure to give a crude product. The pure 2-chloro-N-(2-(piperidin-1-yl)phenyl) nicotinamide (1b) was obtained by column chromatography (EtOAc:PE = 8:1) purification.yield 88%; yellow powder; mp 76-77 °C; 1H-NMR (CDCl3) δ 9.77 (s, 1H, NH), 8.53 (dd, J = 4.8,2.0 Hz, 2H, pyridyl-H), 8.22 (dd, J = 7.7, 2.0 Hz, 1H, pyridyl-H), 7.42 (dd, J = 7.7, 4.8 Hz, 1H, Ar-H), 7.25-7.06 (m, 3H, Ar-H), 2.93 (s, 2H, CH2), 2.71 (s, 2H, CH2), 1.88-1.64 (m, 2H, CH2), 1.44-1.22 (m,2H, CH2), 0.97 (d, J = 6.4 Hz, 2H, CH2); 13C-NMR (CDCl3) δ 162.10, 150.81, 146.72, 142.92, 139.71,133.20, 131.83, 125.24, 124.31, 122.62, 120.93, 119.21, 53.90, 26.44, 23.62; HRMS (ESI), m/z calcdfor C17H19ClN3O (M+H)+ 316.1212, found 316.1211.

Reference： [1]Du, Shijie; Lu, Huizhe; Yang, Dongyan; Li, Hong; Gu, Xilin; Wan, Chuan; Jia, Changqing; Wang, Mian; Li, Xiuyun; Qin, Zhaohai [Molecules, 2015, vol. 20, # 3, p. 4071 - 4087]

8
[ 58757-38-3 ]
[ 39643-31-7 ]
6-chloro-N-(2-(piperidin-1-yl)phenyl)nicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	Stage #1: 2-piperidin-1-yl-phenylamine With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: 6-Chloronicotinoyl chloride In dichloromethane for 0.5h;	3.2.3. Synthesis of Compounds III: 2-Chloro-N-(2-(piperidin-1-yl)phenyl)nicotinamide (1b) General procedure: A solution of 2-(piperidin-1-yl)aniline (0.2 g, 0.025 mol), dichloromethane (25 mL) and triethylamine (0.5 mL) was added to a 50 mL flask and cooled to 0 °C in an ice bath. After ten minutes, 2-chloronicotinoyl chloride (0.22 g) was added [20,21]. The mixture was stirred for 30 min, and then concentrated under reduced pressure to give a crude product. The pure 2-chloro-N-(2-(piperidin-1-yl)phenyl) nicotinamide (1b) was obtained by column chromatography (EtOAc:PE = 8:1) purification yield 88%;

Reference： [1]Du, Shijie; Lu, Huizhe; Yang, Dongyan; Li, Hong; Gu, Xilin; Wan, Chuan; Jia, Changqing; Wang, Mian; Li, Xiuyun; Qin, Zhaohai [Molecules, 2015, vol. 20, # 3, p. 4071 - 4087]

9
[ 5555-00-0 ]
[ 39643-31-7 ]
2-methyl-N-(2-(piperidin-1-yl)phenyl)furan-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%		General procedure: A solution of 2-(piperidin-1-yl)aniline (0.2 g, 0.025 mol), dichloromethane (25 mL) and triethylamine (0.5 mL) was added to a 50 mL flask and cooled to 0 C in an ice bath. After ten minutes, 2-chloronicotinoyl chloride (0.22 g) was added [20,21]. The mixture was stirred for 30 min, and then concentrated under reduced pressure to give a crude product. The pure 2-chloro-N-(2-(piperidin-1-yl)phenyl) nicotinamide (1b) was obtained by column chromatography (EtOAc:PE = 8:1) purification yield 88%;

Reference： [1]Molecules,2015,vol. 20,p. 4071 - 4087

10
[ 39643-31-7 ]
[ 82964-91-8 ]
4-(methylsulfonyl)-N-(2-(piperidin-1-yl)phenyl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
2%	With pyridine at 115℃; for 1h; Microwave irradiation;	4 Example 4 (0134) 4-(methylsulfonyl)-N-(2-(piperidin-l-yl)phenyl)benzenesulfonamide A solution of 2-(piperidin-l-yl)aniline (0.176 g, 1 mmol) in pyridine (Volume: 2 ml) was treated with 4-(methylsulfonyl)benzene-l-sulfonyl chloride (0.255 g, 1.000 mmol). The solution was microwaved at 115°C for 1 hr. To the solution was added toluene (2ml). The solution was concentrated. To the residue was added MeOH (1 ml). The crude product was purified by reversed-phase chromatography (4-100% CTbCN over 15 min) to give desired product (0.002g, 2% yield). (LCMS, ESI pos.) Calculated for C18H22N2O4S2: 395.1 (M + H), Measured: 395.1. NMR (400 MHz, DMSO-d6) d 9.18 (s, 1H), 8.19 - 8.11 (m, 2H), 8.10 - 8.03 (m, 2H), 7.29 (dd, J = 7.5, 1.2 Hz, 1H), 7.20 - 7.13 (m, 2H), 7.09 (ddd, J = 7.8, 5.7, 3.2 Hz, 1H), 3.31 (s, 3H), 2.52 - 2.47 (m, 4H), 1.63 - 1.41 (m, 6H).

Reference： [1]Current Patent Assignee: NAT CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; UNIVERSITY OF MICHIGAN - WO2021/41866, 2021, A1 Location in patent: Page/Page column 28-29

11
[ 39643-31-7 ]
[ 954377-22-1 ]
N-[2-(1-piperidinyl)phenyl]-5-(trifluoromethyl)thiophene-2-sulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
4.9%	With trimethylamine In dichloromethane at 0 - 20℃;	48.4 Step 4 To a stirred solution of compound 48C (320 mg, 1.3 mmol, 1 eq) and compound 4F (224 mg, 1.3 mmol, 1 eq) in di chloromethane was added tri ethylamine (262 mg, 2.6 mmol, 2 eq) at 0 °CO The reaction was allowed to warm to room temperature and stirred overnight. TLC showed the reaction was completed. The reaction was concentrated in vacuum and the residue was purified by flash chromatography on silica gel (0-15% of ethyl acetate in petroleum ether) to afford compound 48 (25 mg, HPLC=99.0%, Yield=4.9%) as a white solid. MS-ESI: [M+l]+= 391.0 'H NMR (400 MHz, CDCI3): δ 8.30 (br, 1H), 7.64 (d, 1H), 7.42 (br, 1H), 7.31 (d, 1H), 7.17-7.11 (m, 3H), 2.76-2.27 (m, 4H), 1.82-1.69 (m, 6H).
4.9%	With trimethylamine In dichloromethane at 0 - 20℃;	48.4 Step 4 To a stirred solution of compound 48C (320 mg, 1.3 mmol, 1 eq) and compound 4F (224 mg, 1.3 mmol, 1 eq) in di chloromethane was added tri ethylamine (262 mg, 2.6 mmol, 2 eq) at 0 °CO The reaction was allowed to warm to room temperature and stirred overnight. TLC showed the reaction was completed. The reaction was concentrated in vacuum and the residue was purified by flash chromatography on silica gel (0-15% of ethyl acetate in petroleum ether) to afford compound 48 (25 mg, HPLC=99.0%, Yield=4.9%) as a white solid. MS-ESI: [M+l]+= 391.0 'H NMR (400 MHz, CDCI3): δ 8.30 (br, 1H), 7.64 (d, 1H), 7.42 (br, 1H), 7.31 (d, 1H), 7.17-7.11 (m, 3H), 2.76-2.27 (m, 4H), 1.82-1.69 (m, 6H).

Reference： [1]Current Patent Assignee: LYSOWAY THERAPEUTICS - WO2022/76383, 2022, A1 Location in patent: Paragraph 00347; 00350
[2]Current Patent Assignee: LYSOWAY THERAPEUTICS - WO2022/76383, 2022, A1 Location in patent: Paragraph 00347; 00350

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P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 39643-31-7 ] {[proInfo.proName]}

Quality Control of [ 39643-31-7 ]

Related Doc. of [ 39643-31-7 ]

Product Details of [ 39643-31-7 ]

Safety of [ 39643-31-7 ]

Application In Synthesis of [ 39643-31-7 ]

[ 39643-31-7 ] Synthesis Path-Downstream 1~11

Related Functional Groups of [ 39643-31-7 ]

Aryls

Amines

Related Parent Nucleus of [ 39643-31-7 ]

Piperidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 39643-31-7 ]

Related Parent Nucleus of
[ 39643-31-7 ]