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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 56-57-5 Chemical Structure| 56-57-5
Chemical Structure| 56-57-5

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4-Nitroquinoline N-oxide is a chemical carcinogen that induces DNA damage and promotes apoptosis in cells through the p53 pathway. It is significant for cancer mechanism research.

Synonyms: 4-NQO; Nitrochin

4.5 *For Research Use Only !

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Product Citations

Product Citations

Boyao Zhang ; George-Eugen Maftei ; Bartosz Bartmanski ; Michael Zimmermann ;

Abstract: Organic carcinogens, in particular DNA-reactive compounds, contribute to the irreversible initiation step of tumorigenesis through introduction of genomic instability. Although carcinogen bioactivation and detoxification by human enzymes has been extensively studied, carcinogen biotransformation by human-associated bacteria, the microbiota, has not yet been systematically investigated. We tested the biotransformation of 68 mutagenic carcinogens by 34 bacterial species representative for the upper and lower human gastrointestinal tract and found that the majority (41) of the tested carcinogens undergo bacterial biotransformation. To assess the functional consequences of microbial carcinogen metabolism, we developed a pipeline to couple gut bacterial carcinogen biotransformation assays with Ames mutagenicity testing and liver biotransformation experiments. This revealed a bidirectional crosstalk between gut microbiota and host carcinogen metabolism, which we validated in gnotobiotic mouse models. Overall, the systematic assessment of gut microbiota carcinogen biotransformation and its interplay with host metabolism highlights the gut microbiome as an important modulator of exposome-induced tumorigenesis.

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Product Details of 4-Nitroquinoline N-oxide

CAS No. :56-57-5
Formula : C9H6N2O3
M.W : 190.15
SMILES Code : O=[N+](C1=C2C=CC=CC2=[N+]([O-])C=C1)[O-]
Synonyms :
4-NQO; Nitrochin
MDL No. :MFCD00006738
InChI Key :YHQDZJICGQWFHK-UHFFFAOYSA-N
Pubchem ID :5955

Safety of 4-Nitroquinoline N-oxide

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H350
Precautionary Statements:P201-P308+P313
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of 4-Nitroquinoline N-oxide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56-57-5 ]
 

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