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Chemical Structure| 59-87-0 Chemical Structure| 59-87-0

Structure of Nitrofurazone
CAS No.: 59-87-0

Chemical Structure| 59-87-0

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Nitrofurazone is a nitrofuran-class antimicrobial organic compound used as a topical antibiotic ointment effective against gram-positive bacteria, gram-negative bacteria, and on the treatment of trypanosomiasis.

Synonyms: Nitrofural; Furacilin; Dermofural

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Product Citations

Product Citations

Boyao Zhang ; George-Eugen Maftei ; Bartosz Bartmanski ; Michael Zimmermann ;

Abstract: Organic carcinogens, in particular DNA-reactive compounds, contribute to the irreversible initiation step of tumorigenesis through introduction of genomic instability. Although carcinogen bioactivation and detoxification by human enzymes has been extensively studied, carcinogen biotransformation by human-associated bacteria, the microbiota, has not yet been systematically investigated. We tested the biotransformation of 68 mutagenic carcinogens by 34 bacterial species representative for the upper and lower human gastrointestinal tract and found that the majority (41) of the tested carcinogens undergo bacterial biotransformation. To assess the functional consequences of microbial carcinogen metabolism, we developed a pipeline to couple gut bacterial carcinogen biotransformation assays with Ames mutagenicity testing and liver biotransformation experiments. This revealed a bidirectional crosstalk between gut microbiota and host carcinogen metabolism, which we validated in gnotobiotic mouse models. Overall, the systematic assessment of gut microbiota carcinogen biotransformation and its interplay with host metabolism highlights the gut microbiome as an important modulator of exposome-induced tumorigenesis.

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Product Details of Nitrofurazone

CAS No. :59-87-0
Formula : C6H6N4O4
M.W : 198.14
SMILES Code : O=[N+](C1=CC=C(C=NNC(N)=O)O1)[O-]
Synonyms :
Nitrofural; Furacilin; Dermofural
MDL No. :MFCD00003225
InChI Key :IAIWVQXQOWNYOU-FPYGCLRLSA-N
Pubchem ID :5447130

Safety of Nitrofurazone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317-H341-H351-H361-H373-H412
Precautionary Statements:P202-P273-P280-P301+P312-P302+P352-P308+P313

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02099240 Osteomyelitis Early Phase 1 Recruiting September 2019 United States, Kentucky ... More >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD Less <<
NCT00669747 Ductal Carcinoma In Situ Phase 2 Unknown December 2009 United States, Oklahoma ... More >> OU Medical Center Laboratory Recruiting Oklahoma City, Oklahoma, United States, 73104 Contact: William C Dooley, M.D., F.A.C.S.    405-206-5670    William-Dooley@ouhsc.edu    Contact: Linda White, R.N.    (949) 300-9576    lwhite@whmed.com    United States, Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Henry Kuerer, M.D.    713-745-5043    lboehnke@mdanderson.org    Contact: Linda White, R.N.    949 300-9576    lwhite@whmed.com Less <<
NCT00192985 Trauma Urinar... More >>y Tract Infections Less << Phase 3 Unknown - Denmark ... More >> Rigshospitalet, Copenhagen University Hospital Copenhagen, Denmark, DK-2100 Less <<
NCT03065543 - Recruiting December 31, 2025 Poland ... More >> Silesian Center for Heart Diseases Recruiting Zabrze, Upper Silesia, Poland, 41-800 Contact: Krzysztof Dyrbus    +48600213030    dyrbusk@gmail.com    Principal Investigator: Mariusz Gasior, Prof,MD,PhD          Sub-Investigator: Krzysztof Dyrbus, MD, PhD Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.05mL

1.01mL

0.50mL

25.23mL

5.05mL

2.52mL

50.47mL

10.09mL

5.05mL

References

 

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