Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 401797-02-2 | MDL No. : | MFCD05663853 |
Formula : | C12H15BCl2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | DTAZBCNEXKOLPE-UHFFFAOYSA-N |
M.W : | 272.96 | Pubchem ID : | 15906196 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With [Ir(COD)(OMe)]2-Covalent organic framework (4-iPr) In n-heptane at 100℃; for 24h; Inert atmosphere; | |
97% | Stage #1: bis(pinacol)diborane With C24H28ClIrN2O In n-heptane; isopropyl alcohol at 75℃; for 1h; Sealed tube; Cooling with liquid nitrogen; Inert atmosphere; Stage #2: 1,2-dichloro-benzene In n-heptane; isopropyl alcohol at 75℃; for 18h; Sealed tube; Inert atmosphere; | |
95% | With [Ir(OMe)(1,5-cyclooctadiene)]2; C88H164N2 In n-heptane at 25℃; for 18h; Inert atmosphere; |
95% | With C93H69IrN30O In n-heptane at 90℃; for 8h; Schlenk technique; Inert atmosphere; | 2.5. General procedure for the aromatic CAH borylation General procedure: All the catalytic tests were carried out in a 25 mL Schlenk-tube which was charged subsequently with bis(pinacolato)diboron (31.75 mg, 0.125 mmol), an arene (0.125 mmol), 3 mL of dry heptane and Ir(I)bipyCTF (1.5 mol% Ir). The mixture was stirred at 90 °C for 8 h under a nitrogen atmosphere. At the end of the reaction,the reaction mixture was analyzed by means of GC and GC-MS using dodecane as internal standard and the product yield was determined by 1H NMR using mesitylene as the internal standard. |
94% | With 6Zr(4+)*4O(2-)*4HO(1-)*4C18H12O4(2-)*2C16H10N2O4(2-)*C8H12*Ir(1+)*CH3O(1-) In tetrahydrofuran; n-heptane at 115℃; for 24h; Glovebox; Schlenk technique; Inert atmosphere; | |
93% | With Ir(1+)*C8H12*CH3O(1-)*6C12H6N2O4(2-)*4Zr(4+)*4HO(1-)*4O(2-) In neat (no solvent) at 100℃; for 8h; Glovebox; Inert atmosphere; Sealed tube; | |
93% | With 6C12H6N2O4(2-)*6Zr(4+)*4HO(1-)*4O(2-)*6Ir(1+)*6CH3O(1-)*6C8H12 at 100℃; for 8h; Glovebox; Sealed tube; Inert atmosphere; | 3 C-H Borylation of Arenes Catalyzed by Bipyridine MOF Catalysts Table 1 shows how the reaction conversion percentage (%) varied by reaction solvent, temperature, and time. Exemplary Procedure for bpy-UiO-Ir Catalyzed C-H Borylation of Neat Arenes: As shown in scheme 6, in a glovebox, bpy-UiO-Ir in THF (1.6 mg, 0.5 mol % Ir) was quickly weighed onto a filter paper, charged into a vial and 0.5 mL 1,2-dichlorobenzene was added. Then, 1,2-dichlorobenzene (1.0 mL) and B2pin2 (20.8 mg, 81.9 μmol) were added to the vial and the resultant mixture was transferred to a storage tube. The tube was sealed and heated at 100° C. for 8 h. The reaction mixture was cooled to room temperature and the solid was centrifuged out of suspension in the glovebox. The extract was concentrated in vacuo and purified by preparative TLC (Hexane:EtOAc=9:1) to give 1,2-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene as a colorless solid (41.6 mg, 152.4 μmol, 93.0%). 1H NMR (chloroform-d1, 400 MHz): δ 7.87 (d, 1H, JH-H=1.2 Hz) 7.60 (m, 1H), 7.44 (m, 1H), 1.34 (s, 12H). |
92% | With [Ir(OMe)(1,5-cyclooctadiene)]2 In benzene at 80℃; for 12h; Schlenk technique; Inert atmosphere; regioselective reaction; | |
87% | With (6,6’-dimethoxy-[1,1 ‘-biphenyl]-2,2’-diyl)bis(bis(3 ,5-dimethyl-phenyl)phosphine); [(1,5-cyclooctadiene)(OH)iridium(I)]2 In hexane at 85℃; for 20h; Inert atmosphere; Glovebox; Sealed tube; regioselective reaction; | |
85% | With iridium-bipyridine periodic mesoporous organosilica In cyclohexane at 80℃; for 12h; Inert atmosphere; Schlenk technique; | |
83% | With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)diiridium(I) dichloride In neat (no solvent) at 80°C for 16 h; | |
78% | With 2,2'-bipyridine-4,4'-dicarboxylic acid-iridium complex In methyl cyclohexane at 80℃; for 12h; | |
33% | With sodium triethylborohydride In tetrahydrofuran at 110℃; for 48h; Schlenk technique; Inert atmosphere; chemoselective reaction; | |
82 % Chromat. | With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; for 8h; | |
With cis-Cyclooctene; [Ir(di-t-butylbipyridine)(cyclooctene)(pinacolatoborane)3] In Cyclohexane-d12 at 40℃; | ||
83 % Chromat. | at 80℃; for 16h; | |
With 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; | ||
With 4,4'-di-tert-butyl-2,2'-bipyridine In hexane N2, stirred at 25°C for 8 h; Kugelrohr distillation; elem. anal.; | ||
83 %Chromat. | With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 2,2'-Bipyridine-4,4'-dicarboxylic acid In methyl cyclohexane at 80℃; for 12h; Inert atmosphere; | |
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4′-di-(tert-butyl)-2,2′-bipyridyl In tetrahydrofuran at 80℃; for 24h; High pressure; Inert atmosphere; regioselective reaction; | ||
100 %Spectr. | With C44H74B3IrN2O9Si In hexane at 70℃; for 8h; Glovebox; Sealed tube; | |
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 18h; Inert atmosphere; regioselective reaction; | ||
82 %Chromat. | With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; for 8h; regioselective reaction; | |
Stage #1: bis(pinacol)diborane With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran for 0.0333333h; Inert atmosphere; Sonication; Stage #2: 1,2-dichloro-benzene In tetrahydrofuran at 80℃; for 24h; Inert atmosphere; | ||
With (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere; | ||
83 %Chromat. | With zirconium [2,2'-bipyridine]-5,5'-dicarboxylate metal-organic frameworks loaded with iridium In neat (no solvent) at 100℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With iridium-bipyridine periodic mesoporous organosilica In cyclohexane at 80℃; for 12h; Inert atmosphere; Schlenk technique; | |
81% | With C2F3O2(1-)*C21H34IrN4(1+) at 180℃; for 0.5h; Microwave irradiation; Neat (no solvent); | |
73% | With 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; for 8h; |
73% | With dtbpy In hexane byproducts: H2; pinBH and arene (1.1:1) stirred at 25°C for 8 h; gas chromy.; | |
52% | Stage #1: 1,2-dichloro-benzene; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane With C38H68Cl2Ir2O4P4 In cyclohexane; toluene at 20℃; Inert atmosphere; Sealed tube; Cooling; Stage #2: With ethene In cyclohexane; toluene at 80℃; for 24h; Inert atmosphere; regioselective reaction; | |
With 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; | ||
With (η5-indenyl)(η4-1,5-cyclooctadiene)iridium(I); 1,2-bis(dimethylphosphanyl)ethane In neat (no solvent) at 150℃; for 3.5h; Inert atmosphere; Sealed tube; | ||
73 %Chromat. | With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In hexane at 25℃; for 8h; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70 % Spectr. | In cyclohexane at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With potassium phosphate In hexane; N,N-dimethyl-formamide at 60℃; for 2h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With bis(4,4,5,5-(CH3)4-1,3,2-dioxaborolanyl)-d24 In benzene-d6; Cyclohexane-d12 (Schlenk; N2 atm.) a soln. of complex in cyclohexane-d12 was frozen in NMR tube, dioxaborolanyl-d24 in C6D6 was added, 1,2-dichlorobenzene was added at 0°C; not sepd., detected by NMR spectra at 7.5°C; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | In cyclohexane (Schlenk; N2 atm.) a soln. of complex and 60 equiv of dichlorobenzene incyclohexane was stirred; not sepd., detected by NMR and mass-spectra; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With [Ir(C8H12)(OCH3)]2; 4,4'-di-tertbutylpyridine In further solvent(s) (N2); heating mixt. of iridium compd., bipyridine deriv., benzene deriv., dodecane and silylborane deriv. at 80°C for 4 h; cooling to room temp., chromy. (silica gel, diethyl ether in hexane (gradient from 0% to 5%)), NMR; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | With tert.-butylnitrite In acetonitrile at 80℃; for 2h; | |
54% | With tert.-butylnitrite; dibenzoyl peroxide In acetonitrile at 20℃; for 2h; | |
54% | With tert-butyl nitrite; benzoyl peroxide In acetonitrile MeCN, Cl2C6H3NH2 (1 mmol) and tBuONO (1.5 mmol) added to B2pin2 (1 mmol)and benzoyl peroxide (0.02 mmol), mixt. stirred at room temp. for 2 h; soln. concd. (under reduced pressure), residue chromd.; |
54% | With tert.-butylnitrite; dibenzoyl peroxide In acetonitrile at 20℃; for 4h; | 5 Synthesis of 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane EXAMPLE 5 Synthesis of 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane B2pin2 (1.0 mmol, 305 mg), benzoyl peroxide (0.02 mmol, 5 mg), 3,4-dichloroaniline (1 mmol, 161 mg) and acetonitrile (3 mL) were added in a 25 mL tube-type reactor, followed by the addition of tert-butyl nitrite (1.5 mmol, 154 mg). The reaction was conducted at room temperature for 4 h. The solution was concentrated after the reaction and the resultant was purified by column chromatography (eluted by petroleum ether:ethyl acetate=20:1, V:V) to give 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane having the following structure: This compound is colorless liquid and obtained in 54% yield. Its NMR data are as follows: 1H NMR (400 MHz, CDCl3) δ 7.86 (d, 1H, J=1.4 Hz), 7.60 (dd, 1H, J1=1.4 Hz, J2=7.9 Hz), 7.43 (d, 1H, J=7.9 Hz), 1.34(s, 12H); 13C NMR (100 MHz, CDCl3) δ 136.5, 135.4, 133.7, 132.2, 129.9, 84.3, 24.8. |
54% | With tert.-butylnitrite; dibenzoyl peroxide In acetonitrile at 20℃; for 4h; | 5 Synthesis of 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane B2pin2 (1.0 mmol, 305 mg), benzoyl peroxide (0.02 mmol, 5 mg), 3,4-dichloroaniline (1 mmol, 161 mg) and acetonitrile (3 mL) were added in a 25 mL tube-type reactor, followed by the addition of tert-butyl nitrite (1.5 mmol, 154 mg). The reaction was conducted at room temperature for 4 h. The solution was concentrated after the reaction and the resultant was purified by column chromatography (eluted by petroleum ether : ethyl acetate = 20:1, V:V) to give 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane having the following structure: This compound is colorless liquid and obtained in 54% yield. Its NMR data are as follows: 1H NMR (400MHz, CDCl3) δ 7.86 (d, 1H, J=1.4Hz), 7.60 (dd, 1H, J1=1.4Hz, J2=7.9Hz), 7.43 (d, 1H, J=7.9Hz), 1.34(s, 12H); 13C NMR (100MHz, CDCl3) δ 136.5, 135.4, 133.7, 132.2, 129.9, 84.3, 24.8. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With sodium hydroxide In 1,4-dioxane; water at 30℃; for 16h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | In 1,4-dioxane 1.0 equiv. NaOH, 3 equiv. H2O, 30°C; stirred for 16 h; chromy.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | Stage #1: (S)-N,N-diisopropylcarbamic acid 1-phenyl-but-3-enyl ester With sec.-butyllithium In diethyl ether; hexane; cyclohexane at -78℃; for 1h; Inert atmosphere; Stage #2: 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In diethyl ether; hexane; cyclohexane; toluene at -78℃; for 2h; Inert atmosphere; optical yield given as %ee; Further stages; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | Stage #1: C17H27NO2 With sec.-butyllithium In diethyl ether; hexane; cyclohexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In diethyl ether; hexane; cyclohexane; toluene at -78℃; for 2h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | In diethyl ether at 20℃; for 17h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 7 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C 4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; <i>tert</i>-butyl alcohol / 0.5 h / 20 °C 5.1: chlorosulfonic acid / dichloromethane / 1.5 h / 20 °C 6.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 4 h / -10 °C 6.2: 0.5 h / 20 °C 7.1: triethylamine / tetrahydrofuran / 1 h / -20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 9 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C 4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; <i>tert</i>-butyl alcohol / 0.5 h / 20 °C 5.1: chlorosulfonic acid / dichloromethane / 1.5 h / 20 °C 6.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 4 h / -10 °C 6.2: 0.5 h / 20 °C 7.1: triethylamine / tetrahydrofuran / 1 h / -20 °C 8.1: tetrahydrofuran / -20 - 20 °C 9.1: methanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: tetrahydrofuran / 2 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 7 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: tetrahydrofuran / 2 h / 20 °C 4.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 20 °C 5.1: Jones reagent / acetone / 0 - 20 °C 6.1: chlorosulfonic acid / dichloromethane / 0.75 h / 20 °C 7.1: sodium acetate / ethanol / 15 h / Reflux 7.2: 20 h / 20 °C / 760.05 Torr |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: tetrahydrofuran / 2 h / 20 °C 4.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: tetrahydrofuran / 2 h / 20 °C 4.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 20 °C 5.1: Jones reagent / acetone / 0 - 20 °C 6.1: chlorosulfonic acid / dichloromethane / 0.75 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: tetrahydrofuran / 2 h / 20 °C 4.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 20 °C 5.1: Jones reagent / acetone / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 8 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C 4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; <i>tert</i>-butyl alcohol / 0.5 h / 20 °C 5.1: chlorosulfonic acid / dichloromethane / 1.5 h / 20 °C 6.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 4 h / -10 °C 6.2: 0.5 h / 20 °C 7.1: triethylamine / tetrahydrofuran / 1 h / -20 °C 8.1: tetrahydrofuran / -20 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C 4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; <i>tert</i>-butyl alcohol / 0.5 h / 20 °C 5.1: chlorosulfonic acid / dichloromethane / 1.5 h / 20 °C 6.1: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 4 h / -10 °C 6.2: 0.5 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C 4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; <i>tert</i>-butyl alcohol / 0.5 h / 20 °C 5.1: chlorosulfonic acid / dichloromethane / 1.5 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: sec.-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: cesium fluoride / dichloromethane; water / 16 h / 20 °C 3.1: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 4 h / 20 °C 4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; <i>tert</i>-butyl alcohol / 0.5 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: tetrafluoroboric acid / water / 0.17 h / 0 °C 1.2: 1 h / 0 °C 1.3: 2.5 h / 20 °C / Inert atmosphere 2.1: diethyl ether / 4 h / 20 °C | ||
Multi-step reaction with 3 steps 1.1: tetrafluoroboric acid / water / 0.17 h / 0 °C 1.2: 1 h / 0 °C 1.3: 20 °C / Inert atmosphere 2.1: 1 h / 0 - 20 °C / Inert atmosphere 3.1: diethyl ether / 4 h / 20 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
42% | Stage #1: (S)-N,N-diisopropylcarbamic acid 1-phenyl-but-3-enyl ester With sec.-butyllithium Inert atmosphere; Schlenk technique; Stage #2: 2-(3,4-dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane at -78 - 20℃; Inert atmosphere; Schlenk technique; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.221 g | With copper(l) iodide; 1,10-Phenanthroline; potassium iodide In methanol; water at 80℃; for 1h; High pressure; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | Stage #1: diisopropopylaminoborane; 1,2-dichloro-4-diazoniumbenzene tetrafluoroborate With bis(cyclopentadienyl)titanium dichloride In acetonitrile at 20℃; for 2.5h; Stage #2: With methanol In acetonitrile at 0 - 20℃; for 1h; Stage #3: 2,3-dimethyl-2,3-butane diol In diethyl ether; acetonitrile at 20℃; for 4h; | 33.VIA19 Example 3: General procedure D for the synthesis of the arylpinacolboronates by arylation of diisopropylaminoborane, catalysed by ferrocene (1%), followed by methanolysis and transesterification In a dried tube reactor under argon as described in example 2, the arenediazonium salt (1 mmol) and the ferrocene (ΙΟμιηοΙ, 1.8mg) were dissolved in 2mL of anhydrous CH3CN. Diisopropylaminoborane (2mmol, 226mg) was then added to the solution and the mixture was stirred for 2h30 at room temperature. The reaction mixture was quenched by a slow addition of anhydrous MeOH at 0°C (2mL) and stirred for an additional hour at room temperature. After removal of all the volatiles, 1.3eq of pinacol was added in Et20 (2mL), the mixture was stirred 4h at room temperature. The crude mixture was washed with a 50g/L CuCl2 solution (2 x 5mL). The organic layer were separated, dried over Na2S04, filtered and concentrated to dryness. The resulted oil was dissolved with CH2C12 and filtered of a pad of silica gel, eluting with CH2C12 to afford the corresponding boronate. Example 33: Synthesis of the arylpinacolboronates by arylation of diisopropylaminoborane., catalysed by a titanocene (1%), followed by methanolysis and transesterification Compounds VIAI to VIA22, IA24 and VIA26 were prepared using the procedure D (example 3), by replacing the ferrocene (1%) by the titanocene Cp2TiCl2 (1%). The yields are shown in the table 1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In ethanol; water; toluene for 14h; Inert atmosphere; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In diethyl ether at 20℃; for 4h; Inert atmosphere; | GENERAL PROCEDURE C FOR THE SYNTHESIS OF THE ARYL BORONATES WITH TITANIUM CATALYST General procedure: In a dried tube reactor under argon, were dissolved the diazonium salt (1 mmol) and titanocenedichloride (10μmol, 2.5mg) in 2mL of anhydrous CH3CN. Diisopropylaminoborane (2mmol 226mg) is then added to the solution and stirred for 2h30 at room temperature. The reaction mixture is quenched by a slow addition of anhydrous MeOH at 0°C (2mL) and stirred for an additional hour at room temperature. After removal of all the volatiles, 1.3eq of pinacol is added in Et2O (2mL), the mixture is stirred 4h at room temperature. The crude mixture is washed with a 50g/L CuCl2 solution (2 x 5mL). The organic layer is separated, dried over Na2SO4, filtred and concentrated to dryness. The resulted oil is dissolved with CH2Cl2 and filtered of a pad of silica gel, eluting with CH2Cl2 to afford the corresponding boronate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I) In tetrahydrofuran at 70℃; for 16h; Inert atmosphere; Sealed tube; | Carboxylation of Arylboronic Esters with PMC; Typical Procedure General procedure: In a glovebox, Cu(IPr)Cl catalyst and PMC (62.8 mg, 0.55 mmol,1.1 equiv) were charged to a glass reaction tube. A solution of 3(0.50 mmol) in THF (1.5 mL) was added, the tube was sealed, taken out of the glovebox, and heated at 70 °C for 16 h. After cooling tor.t., H2O (2 mL) was added and the reaction mixture was acidified with aqueous HCl (1 M), and saturated with sodium chloride. After extraction with EtOAc (3 × 5 mL), the organic phase was dried overanhydrous sodium sulfate and concentrated under vacuo. The product was purified by silica gel column chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium azide; copper(II) bis(trifluoromethanesulfonate) In ethanol at 40℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: sodium azide; copper(II) bis(trifluoromethanesulfonate) / ethanol / 12 h / 40 °C 2: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate / water / 14 h / 20 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | Stage #1: lutidine; 1,2-dichloro-benzene With aluminum (III) chloride In dimethylsulfoxide-d6; 1,2-dichloro-benzene for 72h; Glovebox; Sealed tube; Heating; Stage #2: 2,3-dimethyl-2,3-butane diol With triethylamine In dimethylsulfoxide-d6; dichloromethane; 1,2-dichloro-benzene at 0 - 20℃; for 14h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
173 mg | With triethylamine In dimethylsulfoxide-d6; dichloromethane at 0 - 20℃; for 14h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With magnesium In tetrahydrofuran at 25℃; for 3h; Inert atmosphere; | General procedure for the synthesis of compounds 1a-1m General procedure: To a solution containing 4-IboxBpin (0.651 g,2.0 mmol) and anhydrous THF (8 mL) under Ar, Mg turnings (0.048 g,2.0 mmol) were added. The corresponding halide reagent (2.0 mmol) wasthen introduced dropwise over 5 min with constant stirring at 25 C. Thereaction was complete after 3 h, as evidenced by the disappearance of4-IboxBpin (d +21.6) via 11B NMR. 1 M HCl (3 mL) was then added to thereaction flask and left to stir for 5 min. The reaction mixture was thentransferred to a separatory funnel and extracted with diethyl ether(3 15 mL). The combined organic layers were dried over anhydrous MgSO4,filtered, and dried in vacuo, (25 C, 1 Torr) to afford the correspondingpinacolboronate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With (η5-indenyl)(η4-1,5-cyclooctadiene)iridium(I); 1,2-bis(dimethylphosphanyl)ethane; water-d2 In tetrahydrofuran at 150℃; for 0.5h; Sealed tube; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium fluoride; copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; [2.2.2]cryptande In N,N-dimethyl-formamide for 0.166667h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With pyridine; cesium fluoride In dimethyl sulfoxide at 105℃; for 2h; Inert atmosphere; Schlenk technique; | For Solid Aryl Iodides; General Procedure A General procedure: An oven-dried Schlenk tube, containing a Teflon-coated magnetic stir bar was charged with CsF (228 mg, 1.5 mmol, 3 equiv), bispinacolatodiboron (254 mg, 1 mmol, 2 equiv), and the appropriate aryl iodide (0.5 mmol). Under an argon atmosphere, freshly distilled DMSO (0.4 mL) and pyridine (0.4 to 1 equiv) were added successively using a syringe. The reaction mixture was heated to 105 °C and stirred and stirred for 2 h under argon. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.124 g | With copper diacetate; triethylamine; sodium nitrite In acetonitrile at 80℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.134 g | With 1,10-Phenanthroline; copper diacetate In N,N-dimethyl-formamide at 20℃; for 12h; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 80℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: tetrahydrofuran; hexane / 1 h / 20 °C 2: copper(I) bromide / tetrahydrofuran; hexane / 1 h / 20 °C 3: trifluoroacetic acid / 2 h / 80 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59.3 mg | With sodium peroxoborate tetrahydrate In tetrahydrofuran; water monomer at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | Stage #1: 1,2-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene With n-butyllithium In tetrahydrofuran; hexane at 25℃; for 1h; Stage #2: N,N'-di-tert-butyldiaziridin-3-one With copper(II) bromide In tetrahydrofuran; hexane at 25℃; for 1h; | 20 Example 20. Aromatic urea (see Structural Formula III-t): The arylboronic acid pinacol ester I-t (0.0819g, 0.30mmol) was added to the reaction vessel, 0.6mL of the first organic solvent tetrahydrofuran, n-butyl lithium (0.206mL, 0.33mmol, 1.6M in hexane), stirred at 25 °C for 1h; N,N-di-tert-butyldiaziridin-3-one II (0.0817g, 0.48mmol) was added therein, stirred at 25 °C for 10min; and then CuBr ( 0.0430g, 0.30 mmol) was added to the reaction vessel and the reaction was carried out at 25 °C for 1 h. Direct column chromatography, the specific conditions are: the column is loaded with petroleum ether, the eluent is a mixture of petroleum ether and ethyl acetate with a volume ratio of 30:1, to give III-t white solid (0.0606g, 64% yield). |
Tags: 401797-02-2 synthesis path| 401797-02-2 SDS| 401797-02-2 COA| 401797-02-2 purity| 401797-02-2 application| 401797-02-2 NMR| 401797-02-2 COA| 401797-02-2 structure
[ 942069-95-6 ]
4,4,5,5-Tetramethyl-2-(3,4,5-trichlorophenyl)-1,3,2-dioxaborolane
Similarity: 1.00
[ 635305-47-4 ]
2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 68716-51-8 ]
2-(3,5-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 195062-61-4 ]
2-(4-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.96
[ 942069-95-6 ]
4,4,5,5-Tetramethyl-2-(3,4,5-trichlorophenyl)-1,3,2-dioxaborolane
Similarity: 1.00
[ 635305-47-4 ]
2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 68716-51-8 ]
2-(3,5-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 195062-61-4 ]
2-(4-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.96
[ 942069-95-6 ]
4,4,5,5-Tetramethyl-2-(3,4,5-trichlorophenyl)-1,3,2-dioxaborolane
Similarity: 1.00
[ 635305-47-4 ]
2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 68716-51-8 ]
2-(3,5-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 195062-61-4 ]
2-(4-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.96
[ 942069-95-6 ]
4,4,5,5-Tetramethyl-2-(3,4,5-trichlorophenyl)-1,3,2-dioxaborolane
Similarity: 1.00
[ 635305-47-4 ]
2-(3-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 68716-51-8 ]
2-(3,5-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.98
[ 195062-61-4 ]
2-(4-Chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Similarity: 0.96
[ 1165935-95-4 ]
4,4,5,5-Tetramethyl-2-(2,3,4-trichlorophenyl)-1,3,2-dioxaborolane
Similarity: 0.95
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :