42185-27-3|2-(2-Oxocyclohexyl)acetonitrile| Ambeed

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Structure of 42185-27-3

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Quality Control of [ 42185-27-3 ] Purity: 95% SDS Specification

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Product Details of [ 42185-27-3 ]

CAS No. :	42185-27-3
Formula :	C₈H₁₁NO
M.W :	137.18
SMILES Code :	N#CCC1C(CCCC1)=O
MDL No. :	MFCD18431742
InChI Key :	NDKUZEVDMZDUGK-UHFFFAOYSA-N
Pubchem ID :	543553

Safety of [ 42185-27-3 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H311-H331
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:	6.1
UN#:	2810
Packing Group:	Ⅲ

Application In Synthesis of [ 42185-27-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 42185-27-3 ]

[ 42185-27-3 ] Synthesis Path-Downstream 1~54

1
[ 1125-99-1 ]
[ 107-14-2 ]
[ 42185-27-3 ]

Yield	Reaction Conditions	Operation in experiment
34%		General procedure: Following the procedures of Stork,15 the cycloketone and pyrrolidine (1.1equiv) were dissolved in benzene or toluene (300mLmol-1 ketone; toluene for n>1) and refluxed for 5-10h (cyclopentanone and -hexanone) or 24-48h (cycloheptanone and -octanone). Excess pyrrolidine and solvent were removed under reduced pressure and the yellow to brown oily residue was directly used for further reactions. For medium-sized rings a small amount of p-toluenesulfonic acid was added (n>1). (0024) Next, the enamine (typically 5-20g) was dissolved in anhydrous dioxane (400mLmol-1) under an argon atmosphere. Then the electrophile (1.5equiv; chloroacetonitrile for compounds 1, 3, 5 and 7, or acrylonitrile for compounds 2, 4, 6 and 8) was added in one shot using a syringe. Occasionally, more electrophile was added in case of stagnant reactions. The mixture was refluxed for 10-48h until complete conversion of the enamine could be detected by GC-MS. Subsequently, water (200mLmol-1) was added and the biphasic mixture was heated to reflux for 30-60min. Dioxane was then removed by rotary evaporation and the residue was partitioned between EtOAc (2mLmmol-1) and 2N HCl (0.5mLmmol-1). The aqueous phase was extracted with EtOAc (4× same volume as before) and the pooled extracts were dried over sodium sulfate and concentrated under reduced pressure. Purification of the brown crude oils was performed on MPLC or via distillation.

References: [1]Tetrahedron,2016,vol. 72,p. 7241 - 7248.
[2]Journal of the American Chemical Society,1959,vol. 81,p. 3955,3957.
[3]Russian Journal of Organic Chemistry,1994,vol. 30,p. 582 - 589.
Zhurnal Organicheskoi Khimii,1994,vol. 30,p. 546 - 553.

2
[ 769092-24-2 ]
[ 151-50-8 ]
[ 42185-27-3 ]

References: [1]Chemische Berichte,1955,vol. 88,p. 1340,1343.

3
[ 670-80-4 ]
[ 107-14-2 ]
[ 42185-27-3 ]

References: [1]Bollettino Chimico Farmaceutico,1993,vol. 132,p. 472 - 474.

4
[ 42185-27-3 ]
[ 90242-33-4 ]

References: [1]Journal of Organic Chemistry,1992,vol. 57,p. 7175 - 7187.
[2]Organic Letters,2020,vol. 22,p. 5176 - 5181.
[3]Bollettino Chimico Farmaceutico,1993,vol. 132,p. 472 - 474.

5
[ 42185-27-3 ]
(1R*,2S*)-2-hydroxycyclohexane acetonitrile [ No CAS ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

6
[ 930-68-7 ]
[ 590-17-0 ]
[ 42185-27-3 ]

References: [1]Journal of Organic Chemistry,1987,vol. 52,p. 439 - 443.

7
[ 42185-27-3 ]
[ 107-21-1 ]
[ 95192-95-3 ]

References: [1]Synlett,2010,p. 529 - 534.
[2]Russian Journal of Organic Chemistry,1994,vol. 30,p. 582 - 589.
Zhurnal Organicheskoi Khimii,1994,vol. 30,p. 546 - 553.

8
[ 6982-25-8 ]
[ 42185-27-3 ]
2-Cyanomethyl-4',5'-dimethylspiro<cyclohexane-1,2'-<1,3>dioxolane> [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

9
[ 90242-33-4 ]
[ 42185-27-3 ]

References: [1]Organic letters,2000,vol. 2,p. 2873 - 2876.
[2]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.
[3]Synlett,2010,p. 529 - 534.

10
[ 42185-27-3 ]
[ 100-63-0 ]
(R)-(2-Oxocyclohexyl)ethanenitrile phenylhydrazone [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 149 2-oxocyclohexaneacetonitrile STR151 Cyclohexanone is reacted with bromoacetonitrile by the method of Example 65 to generate the title compound.

13
(+-)-cyano-<2-oxo-cyclohexyl>-acetic acid ethyl ester [ No CAS ]
[ 42185-27-3 ]

References: [1]Canadian Journal of Chemistry,1957,vol. 35,p. 663,669.

14
[ 151-50-8 ]
(+-)-2-piperidinomethyl-cyclohexanone [ No CAS ]
[ 42185-27-3 ]

References: [1]Chemische Berichte,1955,vol. 88,p. 1340,1343.

15
[ 7732-18-5 ]
[ 151-50-8 ]
[ 6966-09-2 ]
[ 42185-27-3 ]

References: [1]Chemische Berichte,1955,vol. 88,p. 1340,1343.

16
[ 42185-27-3 ]
[ 4009-98-7 ]
(Z)-[2-(Methoxymethylene)cyclohexyl]acetonitrile [ No CAS ]
(E)-[2-(Methoxymethylene)cyclohexyl]acetonitrile [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 1265 - 1270.

17
[ 42185-27-3 ]
[ 86296-14-2 ]
C₁₆H₂₁NO₄ [ No CAS ]

References: [1]Organic letters,2000,vol. 2,p. 2873 - 2876.

18
[ 17851-97-7 ]
[ 590-17-0 ]
[ 42185-27-3 ]

References: [1]Organic Letters,2001,vol. 3,p. 2591 - 2594.

19
[ 624-75-9 ]
[ 6651-36-1 ]
[ 42185-27-3 ]

References: [1]Bulletin of the Chemical Society of Japan,2002,vol. 75,p. 2049 - 2052.

20
(E)-8-Oxo-oct-2-enenitrile [ No CAS ]
[ 42185-27-3 ]

References: [1]Organic letters,2000,vol. 2,p. 2873 - 2876.

21
[ 38461-13-1 ]
[ 42185-27-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

22
[ 42185-27-3 ]
2-Carboxymethyl-4',5'-dimethylspiro<cyclohexane-1,2'-<1,3>dioxolane> [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

23
[ 81156-45-8 ]
[ 42185-27-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

24
[ 765-87-7 ]
[ 42185-27-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

25
[2,2-Dimethoxy-cyclohex-(E)-ylidene]-acetonitrile [ No CAS ]
[ 42185-27-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

26
[ 173948-39-5 ]
[ 42185-27-3 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1995,p. 2969 - 2988.

27
[ 42185-27-3 ]
[ 6975-71-9 ]

References: [1]Bollettino Chimico Farmaceutico,1993,vol. 132,p. 472 - 474.

28
[ 42185-27-3 ]
[ 3399-73-3 ]

References: [1]Bollettino Chimico Farmaceutico,1993,vol. 132,p. 472 - 474.

29
[ 42185-27-3 ]
[ 74741-45-0 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

30
[ 42185-27-3 ]
[ 74708-14-8 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

31
[ 42185-27-3 ]
[ 74708-25-1 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

32
[ 42185-27-3 ]
[ 74708-24-0 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

33
[ 42185-27-3 ]
[ 74629-93-9 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

34
[ 42185-27-3 ]
[ 74708-32-0 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

35
[ 42185-27-3 ]
[ 74629-91-7 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

36
[ 42185-27-3 ]
[ 74708-29-5 ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

37
[ 42185-27-3 ]
trans-hexahydro-2(3H)-benzofuranone [ No CAS ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

38
[ 42185-27-3 ]
cis-hexahydrobenzofuran-2(3H)-one [ No CAS ]

References: [1]Journal of Organic Chemistry,1980,vol. 45,p. 4111 - 4117.

39
[ 42185-27-3 ]
[ 1101905-15-0 ]

Yield	Reaction Conditions	Operation in experiment
	With hydroxylamine hydrochloride; sodium acetate; In ethanol; water;	EXAMPLE 150 2-(hydroxyimino)cyclohexaneacetonitrile STR152 The product of Example 149 is reacted with hydroxylamine hydrochloride and sodium acetate in ethanol/water by the method of Example 1 to generate the title compound.

References: [1]Patent: US5883251,1999,A .

40
[ 42185-27-3 ]
[ 7440-16-6 ]
[ 120-72-9 ]

Yield	Reaction Conditions	Operation in experiment
99%	With hydrogen;	EXAMPLE IV In the manner described in Example III, a mixture of 2-oxocyclohexaneacetonitrile and hydrogen is passed over a catalyst composed of rhodium on γ-aluminumoxide (0.5 wt. % Rh). The conversion of the oxonitrile is 99%, and the yields are indole 9%, tetrahydroindole 26% and hexahydroindole 5%.

References: [1]Patent: US4473699,1984,A .

41
[ 42185-27-3 ]
[ 7440-06-4 ]
[ 120-72-9 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogen;	EXAMPLE III In the manner described in Example I, but differing in that the temperature of the catalyst and the inert material is kept at 240 C., a mixture of 2-oxocyclohexaneacetonitrile and hydrogen is passed over a catalyst composed of platinum on γ-aluminumoxide (0.5 wt. % Pt). The oxonitrile conversion is 100%, and the yields are indole 18%, tetrahydroindole 19% and hexahydroindole 1%.

References: [1]Patent: US4473699,1984,A .

42
γ-aluminumoxide [ No CAS ]
[ 42185-27-3 ]
[ 7440-06-4 ]
[ 120-72-9 ]

Yield	Reaction Conditions	Operation in experiment
69%	With hydrogen;	EXAMPLE II In the manner described in Example 1, a mixture of 2-oxocyclohexaneacetonitrile and hydrogen is passed over a catalyst composed of platinum and γ-aluminumoxide (0.5 wt. % platinum). The oxonitrile conversion is 69%, and the yields are indole 11%, tetrahydroindole 12% and hexahydroindole 1%.

References: [1]Patent: US4473699,1984,A .

43
[ 42185-27-3 ]
[ 1046202-48-5 ]
[ 1046202-49-6 ]

References: [1]Advanced Synthesis and Catalysis,2007,vol. 349,p. 2049 - 2053.

44
[ 1125-99-1 ]
[ 590-17-0 ]
[ 42185-27-3 ]

References: [1]Angewandte Chemie - International Edition,2009,vol. 48,p. 8716 - 8720.

45
[ 42185-27-3 ]
[ 1779-49-3 ]
[ 217633-27-7 ]

References: [1]Angewandte Chemie - International Edition,2009,vol. 48,p. 8716 - 8720.

46
[ 42185-27-3 ]
(-)-2-(7-oxooxepan-2-yl)acetonitrile [ No CAS ]
(-)-2-(2-oxooxepan-3-yl)acetonitrile [ No CAS ]
2-(7-oxooxepan-2-yl)acetonitrile [ No CAS ]
(+)-2-(2-oxooxepan-3-yl)acetonitrile [ No CAS ]
2-(2-oxocyclohexyl)acetonitrile [ No CAS ]
2-(2-oxocyclohexyl)acetonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With cyclopentanone MO-type from Comamonas sp. NCIMB 9872; oxygen; In 1,4-dioxane; for 8h;Enzymatic reaction;	General procedure: LB growth medium was inoculated, induced, and charged with additives as described in Section 4.12. The substrate was then added directly to the shake flask as approx. 10% (w/v) solution in dioxane. Incubation at the appropriate temperature was carried out until the desired degree of conversion was determined via GC control. The aqueous solution was then centrifuged (17kRCF, 15min, 4C) and the supernatant was extracted with EtOAc (5× equal volume). The pooled organic layers were washed with brine, dried over sodium sulfate and concentrated. The crude compounds were purified by chromatography on silica using LP/EtOAc mixtures.

References: [1]Tetrahedron,2016,vol. 72,p. 7241 - 7248.

47
[ 42185-27-3 ]
(-)-2-(7-oxooxepan-2-yl)acetonitrile [ No CAS ]
(-)-2-(2-oxooxepan-3-yl)acetonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
19%; 34%	With cyclohexanone MO-type from Brachymonas petroleovorans; oxygen; In 1,4-dioxane; for 10.5h;Enzymatic reaction;	General procedure: LB growth medium was inoculated, induced, and charged with additives as described in Section 4.12. The substrate was then added directly to the shake flask as approx. 10% (w/v) solution in dioxane. Incubation at the appropriate temperature was carried out until the desired degree of conversion was determined via GC control. The aqueous solution was then centrifuged (17kRCF, 15min, 4C) and the supernatant was extracted with EtOAc (5× equal volume). The pooled organic layers were washed with brine, dried over sodium sulfate and concentrated. The crude compounds were purified by chromatography on silica using LP/EtOAc mixtures.

References: [1]Tetrahedron,2016,vol. 72,p. 7241 - 7248.

48
[ 108-94-1 ]
[ 42185-27-3 ]

References: [1]Tetrahedron,2016,vol. 72,p. 7241 - 7248.

49
[ 1438-96-6 ]
[ 42185-27-3 ]

References: [1]Patent: CN104557610,2018,B .

50
[ 1460-35-1 ]
[ 42185-27-3 ]

Yield	Reaction Conditions	Operation in experiment
83%	at 285℃; for 1h;	General procedure: Following the amide intermediate Preparation Example A. The reaction vessel is closed (when the amide intermediate has a boiling point at normal pressure equal to or lower than the reaction temperature TB described below) or the reaction vessel is kept open (when the amide intermediate has a boiling point higher than the normal pressure When the reaction temperature is TB), stirring is continued (600 r/min), the reaction temperature is changed to TB, and after the reaction temperature TB is maintained for TD hours, the reaction is substantially completed. Then, the reaction vessel was sealed and connected to a vacuum pump so that the degree of vacuum in the reaction vessel reached 20-50 mbar (according to the type of nitrile product) and the distillate was used as the nitrile product. The yield of the nitrile product was calculated and sampled for nuclear magnetic resonance and elemental analysis to characterize the nitrile product obtained. Specific reaction conditions and characterization results are shown in Tables A-7, A-8, A-9, A-10, A-11 and A-12 below. These characterization results show that the nitrile product obtained has an extremely high purity (above 99%).In these nitrile product preparation examples, 10 g of phosphorus pentaoxide is preferably added to the reaction vessel as a catalyst at one stage, optionally at the beginning of the reaction.

References: [1]Patent: CN104557610,2018,B .Location in patent: Paragraph 0153; 0154; 0155; 0164; 0165.

51
[ 62791-22-4 ]
[ 107-14-2 ]
[ 42185-27-3 ]

References: [1]Angewandte Chemie - International Edition,2020,vol. 59,p. 9485 - 9490.
Angew. Chem.,2020,vol. 132,p. 9572 - 9577,6.

52
[ 108-94-1 ]
[ 107-14-2 ]
[ 42185-27-3 ]

References: [1]Organic Letters,2020,vol. 22,p. 5176 - 5181.

53
[ 42185-27-3 ]
(Z)-4-(4a,5,6,7,8,8a-hexahydro-4H-[1,2,3]triazolo[1,5-a]indol-3-yl)but-3-en-2-one [ No CAS ]

References: [1]Organic Letters,2020,vol. 22,p. 5176 - 5181.

54
[ 42185-27-3 ]
(E)-4-(4a,5,6,7,8,8a-hexahydro-4H-[1,2,3]triazolo[1,5-a]indol-3-yl)but-3-en-2-one [ No CAS ]

References: [1]Organic Letters,2020,vol. 22,p. 5176 - 5181.

Historical Records

Technical Information

• Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Blaise Reaction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Grignard Reaction • Halogenation • Heat of Combustion • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reformatsky Reaction • Ritter Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Tebbe Olefination • Thorpe-Ziegler Reaction • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

Related Functional Groups of
[ 42185-27-3 ]

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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 42185-27-3

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