[ CAS No. 4435-14-7 ] {[proInfo.proName]}

Name: 4435-14-7|2-Cyclohexylacetonitrile|97%
Brand: Ambeed
SKU: A300702
Price: 65.0 USD
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Cat. No.: {[proInfo.prAm]}

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Inaccessible (Haz class 6.1), International	USD 150+
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Quality Control of [ 4435-14-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 4435-14-7 ]

SDS Specification

Alternatived Products of [ 4435-14-7 ]

Product Details of [ 4435-14-7 ]

CAS No. :	4435-14-7	MDL No. :	MFCD00058667
Formula :	C₈H₁₃N	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MXFPACNADGXIQY-UHFFFAOYSA-N
M.W :	123.20	Pubchem ID :	10953488
Synonyms :

Calculated chemistry of [ 4435-14-7 ]

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.88
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	38.2
TPSA :	23.79 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.17 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.97
Log Po/w (XLOGP3) :	2.65
Log Po/w (WLOGP) :	2.48
Log Po/w (MLOGP) :	1.68
Log Po/w (SILICOS-IT) :	2.26
Consensus Log Po/w :	2.21

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.21
Solubility :	0.764 mg/ml ; 0.0062 mol/l
Class :	Soluble
Log S (Ali) :	-2.8
Solubility :	0.195 mg/ml ; 0.00158 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.76
Solubility :	2.13 mg/ml ; 0.0173 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.7

Safety of [ 4435-14-7 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P361-P363-P403+P233-P405-P501	UN#:	2810
Hazard Statements:	H301-H311-H331	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 4435-14-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 4435-14-7 ]

[ 4435-14-7 ] Synthesis Path-Downstream 1~88

1
[ 4435-14-7 ]
[ 103-78-6 ]

Reference： [1]Journal of the Chinese Chemical Society (Peking),1951,vol. 18,p. 65,69, 74

2
[ 4435-14-7 ]
[ 114906-66-0 ]

Reference： [1]Journal of Organic Chemistry,1950,vol. 15,p. 1082,1087

3
[ 4435-14-7 ]
[ 4442-85-7 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1908,vol. 359,p. 292
Justus Liebigs Annalen der Chemie,1908,vol. 360,p. 29
[2]Justus Liebigs Annalen der Chemie,1907,vol. 353,p. 302
Chemisches Zentralblatt,1907,vol. 78,p. 53

4
[ 1503-87-3 ]
[ 4435-14-7 ]

Yield	Reaction Conditions	Operation in experiment
83%	at 295℃; for 1h;	General procedure: Following the amide intermediate Preparation Example A. The reaction vessel is closed (when the amide intermediate has a boiling point at normal pressure equal to or lower than the reaction temperature TB described below) or the reaction vessel is kept open (when the amide intermediate has a boiling point higher than the normal pressure When the reaction temperature is TB), stirring is continued (600 r/min), the reaction temperature is changed to TB, and after the reaction temperature TB is maintained for TD hours, the reaction is substantially completed. Then, the reaction vessel was sealed and connected to a vacuum pump so that the degree of vacuum in the reaction vessel reached 20-50 mbar (according to the type of nitrile product) and the distillate was used as the nitrile product. The yield of the nitrile product was calculated and sampled for nuclear magnetic resonance and elemental analysis to characterize the nitrile product obtained. Specific reaction conditions and characterization results are shown in Tables A-7, A-8, A-9, A-10, A-11 and A-12 below. These characterization results show that the nitrile product obtained has an extremely high purity (above 99%).In these nitrile product preparation examples, 10 g of phosphorus pentaoxide is preferably added to the reaction vessel as a catalyst at one stage, optionally at the beginning of the reaction.

Reference： [1]Patent: CN104557610,2018,B .Location in patent: Paragraph 0153; 0154; 0155; 0162; 0163
[2]Journal of the American Chemical Society,1951,vol. 73,p. 42
[3]Justus Liebigs Annalen der Chemie,1907,vol. 353,p. 302
Chemisches Zentralblatt,1907,vol. 78,p. 53

5
[ 3213-50-1 ]
[ 4435-14-7 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 5397

6
[ 6975-71-9 ]
[ 4435-14-7 ]

Reference： [1]Journal of the Chinese Chemical Society (Peking),1951,vol. 18,p. 65,69, 74

7
[ 4435-14-7 ]
[ 107-15-3 ]
[ 144505-59-9 ]

Reference： [1]Patent: US2505247,1946,
DRP/DRBP Org.Chem.,
[2]Patent: US2505247,1946,
DRP/DRBP Org.Chem.,

8
[ 4435-14-7 ]
[ 107-99-3 ]
2-cyclohexyl-4-dimethylamino-butyronitrile [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1951,vol. 73,p. 5752,5756

9
[ 4435-18-1 ]
[ 4435-14-7 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398
[2]Chemical Communications,2005,p. 1755 - 1757
[3]Tetrahedron,1996,vol. 52,p. 8611 - 8618
[4]Journal of Organic Chemistry,1975,vol. 40,p. 127 - 128

10
[ 4435-14-7 ]
[ 105-58-8 ]
[ 3213-50-1 ]

Reference： [1]Journal of Organic Chemistry,1977,vol. 42,p. 2009 - 2010

11
[ 4435-14-7 ]
[ 98-89-5 ]

Reference： [1]Journal of Organic Chemistry,1980,vol. 45,p. 3630 - 3634
[2]Journal of Organic Chemistry,1980,vol. 45,p. 3630 - 3634

12
[ 151-50-8 ]
C₂₂H₃₆N₂O₂S [ No CAS ]
[ 4435-14-7 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1980,p. 1487 - 1492

13
[ 4435-14-7 ]
[ 79-19-6 ]
[ 118314-08-2 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

14
[ 142981-64-4 ]
[ 4435-14-7 ]

Reference： [1]Journal of Organic Chemistry,1992,vol. 57,p. 4877 - 4882

15
[ 143-33-9 ]
[ 1072-95-3 ]
[ 4435-14-7 ]

Reference： [1]Journal of the American Chemical Society,1982,vol. 104,p. 5580 - 5585

16
[ 110-82-7 ]
[ 75-05-8 ]
[ 74-90-8 ]
[ 4435-14-7 ]
[ 82166-21-0 ]
[ 107-13-1 ]
[ 107-12-0 ]
[ 110-83-8 ]

Reference： [1]Journal of Organic Chemistry,1982,vol. 47,p. 1475 - 1479

17
[ 75-05-8 ]
[ 110-83-8 ]
[ 1541-20-4 ]
[ 931-17-9 ]
[ 4435-14-7 ]
[ 822-67-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1983,p. 531 - 542

18
[ 75-05-8 ]
[ 110-83-8 ]
[ 4435-14-7 ]

Reference： [1]Journal of the American Chemical Society,1982,vol. 104,p. 5580 - 5585

19
[ 75-05-8 ]
[ 110-83-8 ]
[ 4435-14-7 ]
[ 108-93-0 ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1990,p. 1603 - 1605

20
[ 143-33-9 ]
[ 100-49-2 ]
[ 4435-14-7 ]

Reference： [1]Journal of Organic Chemistry,1981,vol. 46,p. 2985 - 2987

21
[ 150464-47-4 ]
[ 1192-37-6 ]
[ 4435-14-7 ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1989,p. 266 - 267

22
[ 151-50-8 ]
[ 2043-61-0 ]
[ 4435-14-7 ]

Reference： [1]Bulletin of the Chemical Society of Japan,1983,vol. 56,p. 762 - 765

23
[ 110-83-8 ]
[ 1541-20-4 ]
[ 931-17-9 ]
[ 4435-14-7 ]
[ 822-67-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions II,1983,p. 531 - 542

24
[ 183657-81-0 ]
[ 4435-14-7 ]
[ 92-92-2 ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 7791 - 7794

25
[ 59059-70-0 ]
[ 75-05-8 ]
[ 4435-14-7 ]
[ 110-83-8 ]

Reference： [1]Acta Chemica Scandinavica,1999,vol. 53,p. 892 - 900

27
[ 6975-71-9 ]
[ 4435-18-1 ]
[ 4435-14-7 ]
[ 4442-85-7 ]
[ 3399-73-3 ]

Reference： [1]Journal of Catalysis,2005,vol. 234,p. 161 - 171

28
[ 93-89-0 ]
[ 4435-14-7 ]
[ 92646-17-8 ]

Reference： [1]Organic Letters,2006,vol. 8,p. 1161 - 1163

29
[ 4435-14-7 ]
[ 5452-75-5 ]
2,4-dicyclohexyl-3-oxobutyronitrile [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 1161 - 1163

30
[ 4435-14-7 ]
[ 105-37-3 ]
2-cyclohexyl-3-oxopentanenitrile [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 1161 - 1163

31
[ 4435-14-7 ]
[ 97-62-1 ]
2-cyclohexyl-4-methyl-3-oxopentanenitrile [ No CAS ]

Reference： [1]Organic Letters,2006,vol. 8,p. 1161 - 1163

32
[ 40748-84-3 ]
[ 4435-14-7 ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 7791 - 7794

33
[ 183657-58-1 ]
[ 4435-14-7 ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 7791 - 7794

34
[ 4435-14-7 ]
[ 146449-12-9 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

35
[ 4435-14-7 ]
[ 1027897-80-8 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

36
[ 4435-14-7 ]
6-Cyclohexylmethyl-3H-[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9-one [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

37
[ 4435-14-7 ]
[ 118314-18-4 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

38
[ 4435-14-7 ]
[ 146449-24-3 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

39
[ 4435-14-7 ]
[ 146449-37-8 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

40
[ 108-94-1 ]
oxygen [ No CAS ]
[ 4435-14-7 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 2391 - 2398

41
[ 78980-82-2 ]
[ 4435-14-7 ]

Reference： [1]Journal of Organic Chemistry,1992,vol. 57,p. 4877 - 4882

42
[ 2043-61-0 ]
[ 4435-14-7 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1980,p. 1487 - 1492
[2]European Journal of Organic Chemistry,2017,vol. 2017,p. 2379 - 2384

43
[ 23860-35-7 ]
[ 4435-14-7 ]

Reference： [1]Journal of the American Chemical Society,1951,vol. 73,p. 42

44
[ 108-85-0 ]
[ 4435-14-7 ]

Yield	Reaction Conditions	Operation in experiment
	In ethyl acetate; N,N-dimethyl-formamide;	A. Cyclohexyl acetonitrile A solution of sodium cyanide (2.77 g, 56.5 mmol) in 70 ml of DMF was treated with cyclohexyl bromide (7.9 ml, 56.5 mmol), under N2. The reaction mixture was reacted for 48 hours and then partitioned between EtOAc and H2 O. The resultant layers were separated and the organic layer was concentrated in vacuo. The crude material was purified using flash chromatography (eluent of 5% EtOAc in hexanes). Yield: 5.0 g of a clear liquid (72%). 1 H NMR (d6 -DMSO): delta0.65-1.30 (m, 5H), 1.35-1.80 (m, 6H), 2.38 (d, 2H).
	In ethyl acetate; N,N-dimethyl-formamide;	A. Cyclohexyl acetonitrile A solution of sodium cyanide (2.77 g, 56.5 mmol) in 70 ml of DMF was treated with cyclohexyl bromide (7.9 ml, 56.5 mmol), under N2. The reaction mixture was reacted for 48 hours and then partitioned between EtOAc and H2O. The resultant layers were separated and the organic layer was concentrated in vacuo. The crude material was purified using flash chromatography (eluent of 5% EtOAc in hexanes). Yield: 5.0 g of a clear liquid (72%). 1H NMR (d6-DMSO): delta 0.65-1.30 (m, 5H), 1.35-1.80 (m, 6H), 2.38 (d, 2H).

Reference： [1]Patent: US6060484,2000,A
[2]Patent: EP806205,1997,A3

45
[ 4435-14-7 ]
isopropyl cyclohexylacetimidate hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		The isopropyl cyclohexylacetimidate hydrochloride used as the starting material was prepared as follows: In a manner analogous to that described in Example 1, from <strong>[4435-14-7]cyclohexylacetonitrile</strong>, there was obtained isopropyl cyclohexylacetimidate hydrochloride in the form of a pale pink solid of melting point 108-110 C.

Reference： [1]Patent: US5399712,1995,A

46
[ 52407-43-9 ]
[ 4435-14-7 ]
[ 128104-98-3 ]

Yield	Reaction Conditions	Operation in experiment
		Step (2) Preparation of 4-[(3-Benzofuranyl)methyl]-3H-1,2,3,5-oxathiadiazole 2-Oxide According to Scheme I illustrated by Example 4, 3-benzofuranylacetonitrile was converted to the desired product as beige crystals, m.p. 138.5-140 C. temperature. Cyclohexylacetonitrile (14.7 g, 120 mmol) was added in one portion and the resulting mixture was heated to reflux for 12 hours. The mixture was cooled to room temperature and concentrated to give a yellow solid. The solid was collected by filtration, washed with water, EtOAc/hexane (2:8), and dried in vacuo to give 7.4 g (40%) of the product of sufficient purity for use in the next reaction. NMR (DMSO-d6, 200 MHz): delta 0.85 (m, 2H), 1.10 (m, 3H), 1.64 (m, 6H), 1.80 (d, J=7.0, 2H), 5.25 (br s, 2H), 8.30 (br s, 1H).

Reference： [1]Patent: US4895860,1990,A

47
[ 1189-71-5 ]
[ 5292-21-7 ]
[ 4435-14-7 ]

Yield	Reaction Conditions	Operation in experiment
14.6 g (85%)	In dichloromethane; N,N-dimethyl-formamide;	Step (1) Preparation of Cyclohexylacetonitrile A solution of the cyclohexylacetic acid (20.0 g, 141 mmol) in CH2 Cl2 (80 mL) was heated to reflux and a solution of chlorosulfonyl isocyanate (20.9 g, 148 mmol) in CH2 Cl2 (18 mL) was added dropwise over 40 minutes. After the addition was complete, stirring was continued at reflux for 65 minutes. The mixture was cooled to 0 C., and DMF (21.1 g, 288 mmol) was added dropwise. The mixture was allowed to warm to room temperature and stirred 18 hours. The mixture was poured over ice, the organic layer separated, and the aqueous layer extracted with CH2 Cl2 (50 mL). The combined organic layers were washed with water (3*50 mL), brine, dried (Na2 SO4), filtered through a plug of Florosil and concentrated. The nitrile was obtained as 14.6 g (85%) of an oil of sufficient purity for use in the next reaction. NMR (DMSO-d6, 200 MHz): delta 1.10 (m, 5H), 1.62 (m, 6H), 2.40 (d, J=7.0, 2H).

Reference： [1]Patent: US4895860,1990,A

48
[ 956465-10-4 ]
[ 110-82-7 ]
[ 75-05-8 ]
[ 3144-09-0 ]
[ 92-51-3 ]
[ 4435-14-7 ]
[ 19299-40-2 ]

Reference： [1]Journal of Organic Chemistry,2008,vol. 73,p. 4398 - 4414

49
[ 71996-32-2 ]
[ 110-82-7 ]
[ 75-05-8 ]
[ 132-65-0 ]
[ 92-51-3 ]
[ 4435-14-7 ]
[ 70-55-3 ]

Reference： [1]Journal of Organic Chemistry,2008,vol. 73,p. 4398 - 4414

50
potassium cyanide [ No CAS ]
[ 2550-36-9 ]
[ 4435-14-7 ]

Reference： [1]Journal of the American Chemical Society,2009,vol. 131,p. 17376 - 17386

51
[ 7766-50-9 ]
[ 4435-14-7 ]
C₁₉H₃₃N [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2009,vol. 131,p. 17376 - 17386

52
[ 609-12-1 ]
[ 4435-14-7 ]
C₁₅H₂₇NO₂ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

53
[ 4435-14-7 ]
[ 1030017-20-9 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

54
[ 4435-14-7 ]
[ 1030017-21-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

55
[ 4435-14-7 ]
[ 1268381-89-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

56
[ 4435-14-7 ]
[ 1174559-33-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697
[2]European Journal of Medicinal Chemistry,2017,vol. 128,p. 168 - 179
[3]Patent: CN106866548,2017,A

57
[ 4435-14-7 ]
[ 1030017-22-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

58
[ 4435-14-7 ]
[ 1030017-25-4 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

59
[ 4435-14-7 ]
[ 1030017-28-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 694 - 697

60
[ 4435-14-7 ]
2-cyclohexyl-N-hydroxyacetimidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
47%	With hydroxylamine hydrochloride; sodium hydrogencarbonate; In isopropyl alcohol; at 80 - 85℃;	To a solution of 0.846 g (8.1 mmol) of hydroxylamine hydrochloride in 1 1 mL of isopropyl alcohol, 1 .499 g (17.8 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25 C to 30 C for 10 - 15 min. 1 .0 g (8.1 mmol) of 2- <strong>[4435-14-7]cyclohexylacetonitrile</strong> was added and stirred at 80 C to 85 C for 3 - 4 h. After completion of the reaction, the reaction mixture was cooled to 25 C to 30 C, filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue. The residue was chased with 5 mL of toluene to yield the title compound.Yield: 0.6 g (47 %).

Reference： [1]Patent: WO2011/104680,2011,A1 .Location in patent: Page/Page column 87

61
[ 4435-14-7 ]
[ 404912-30-7 ]
C₁₉H₂₆N₂O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In toluene; at 25 - 30℃;Inert atmosphere;	To a solution of 0.39 g (1 .88 mmol) of 3-(3,4-dimethoxy-phenyl)-acrylic acid (compound of Example 2; Step 1 ) in 6 mL of toluene, 0.333 g (2.00 mmol) of 1 ,1 - carbonyldiimidazole was added in portions at 25 C to 30 C under inert atmosphere. To the thickened mixture, 5 mL of toluene was added and the resulting mixture was stirred at 25 C to 30 C for 60 to 90 min. A solution of 2-cyclohexyl-N- hydroxyacetimidamide (compound of Example 44; 0.6 g, 3.8 mmol) in 5 mL of toluene was added to the above reaction mixture at 25 C to 30 C. The reaction mass was stirred at 25 C to 30 C under nitrogen for 12 - 14 h, followed by stirring at 100 C to 105 C for 6 - 8 h. After completion of the reaction, the reaction mixture was cooled to 25 C to 30 C and quenched with 10 mL of chilled water under stirring at 25 C to 30 C. The organic layer was separated, and the aqueous layer was washed with 5 mL of toluene. The organic layers were combined and washed with 10 mL of 1 N HCI solution, 10 mL of 5 % sodium bicarbonate solution and 10 mL of 10 % sodium chloride solution. The organic layer was distilled completely to obtain a crude residue, which was purified by column chromatography (silica gel, chloroform - methanol) to yield the title compound.Yield: 0.22 g (35 %).

Reference： [1]Patent: WO2011/104680,2011,A1 .Location in patent: Page/Page column 87-88

62
[ 75-05-8 ]
[ 108-93-0 ]
[ 4435-14-7 ]

Reference： [1]Chemistry Letters,2011,vol. 40,p. 1055 - 1057

63
[ 17715-00-3 ]
[ 4435-14-7 ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 6677 - 6680
Angew. Chem.,2013,vol. 125,p. 6809 - 6612,4

64
[ 1189-71-5 ]
[ 622-45-7 ]
[ 4435-14-7 ]

Yield	Reaction Conditions	Operation in experiment
66g	In dichloromethane; at 38℃; for 4h;Reflux;	Cyclohexyl acetate (part number C0589, manufactured by Tokyo Chemical Industry Co., Ltd.) 90 g, dichloromethane (model number 22415-13,manufactured by Nacalai Tesque) were mixed 400mL to 38 C. until allowed to warm, it was added dropwise here chlorosulfonyl isocyanate (ModelC0886, manufactured by Tokyo Chemical industry Co., Ltd.) 95 g over a period of solution for 1.5 hours, dissolved in dichloromethane 100 mL. Afterthe completion of the dropping, the reaction was carried out under reflux for 2.5 hours.After refluxing, by cooling the reaction mixture to -4 C., dimethylformamide (model number 000-24933, Kishida Chemical Co., Ltd.) was addeddropwise over one hour 110 g. After completion of the dropwise addition, the mixture was stirred for 20 hours at room temperature is graduallyheating the reaction solution. The reaction mixture was poured into cold water, extracted with chloroform, washed with water, was concentrated, theresulting oil component is purified by vacuum distillation, to obtain a cyclohexyl acetonitrile (a-1) 66g.

Reference： [1]Patent: JP2016/11348,2016,A .Location in patent: Paragraph 0046

65
[ 4435-14-7 ]
cis-1-cyclohexyl-2-(2-chlorophenyl)-1,2-dicyanoethylene [ No CAS ]

Reference： [1]Patent: JP2016/11348,2016,A

66
[ 4435-14-7 ]
C₆₄H₆₀Cl₄CuN₈ [ No CAS ]

Reference： [1]Patent: JP2016/11348,2016,A

67
[ 4435-14-7 ]
[ 35022-42-5 ]
trans-1-cyclohexyl-2-(2-chlorophenyl)-1,2-dicyanoethylene [ No CAS ]