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Chemical Structure| 822-67-3 Chemical Structure| 822-67-3

Structure of 822-67-3

Chemical Structure| 822-67-3

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Product Details of [ 822-67-3 ]

CAS No. :822-67-3
Formula : C6H10O
M.W : 98.14
SMILES Code : OC1C=CCCC1
MDL No. :MFCD00001570
InChI Key :PQANGXXSEABURG-UHFFFAOYSA-N
Pubchem ID :13198

Safety of [ 822-67-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225
Precautionary Statements:P210-P403+P235
Class:3
UN#:1987
Packing Group:

Application In Synthesis of [ 822-67-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 822-67-3 ]

[ 822-67-3 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 279-49-2 ]
  • [ 6995-79-5 ]
  • [ 931-71-5 ]
  • [ 822-67-3 ]
  • [ 822-66-2 ]
  • 2
  • [ 75-05-8 ]
  • [ 110-83-8 ]
  • [ 1541-20-4 ]
  • [ 931-17-9 ]
  • [ 4435-14-7 ]
  • [ 822-67-3 ]
  • 3
  • [ 110-83-8 ]
  • [ 1541-20-4 ]
  • [ 931-17-9 ]
  • [ 4435-14-7 ]
  • [ 822-67-3 ]
  • 4
  • [ 19418-11-2 ]
  • [ 930-68-7 ]
  • [ 1123-25-7 ]
  • [ 103668-33-3 ]
  • [ 822-67-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; ammonium chloride; In tetrahydrofuran; diethyl ether; 1-methylcyclohexane-1-carboxylic acid (10 g) in tetrahydrofuran was added dropwise to a stirred solution of lithium aluminium hydride (2.5 g) in tetrahydrofuran. After 1 h, saturated aqueous ammonium chloride then dilute hydrochloric acid were added, and the mixture was extracted with chloroform (x 3). The combined organic phase was dried (Na2SO4) and evaporated to yield the title alcohol as a colourless syrup (8 g), single component by g.c.-m.s. 4 Tetrahydrothiophene-2-methanol: the title alcohol was prepared from <strong>[19418-11-2]tetrahydrothiophene-2-carboxylic acid</strong> (J.T. Wrobel and E. Hejchman, Synthesis 1987, 452) by reduction with lithium aluminium hydride in ether (S. Ikegami, Tetrahedron 1974, 30 , 2087). 5 (RS)-2-Cyclohexene-1-methanol: cyclohexenone (10 g) was added dropwise to a solution of lithium aluminium hydride (2 g) in diethyl ether (50 ml) and the mixture was stirred at ambient temperature for 2 h. Saturated ammonium chloride solution (150 ml) was added, followed by hydrochloric acid (2 M) to dissolve the grey precipitate, and the mixture was extracted with chloroform (x 3), dried (MgSO4) and evaporated to a syrup. Fractional distillation under reduced pressure gave 2-cyclohexen-1-ol as a liquid, a single component by g.c.-m.s. The resulting 2-cyclohexen-1-ol (4 g) was converted to the title alcohol by the method of W. C. Still et al., (J. Am. Chem. Soc., 100 (1978) 1927-8, and after purification by flash crhomatography (silica; eluant ethyl acetate/light petroleum ether, 1:4) was obtained as a colourless liquid (2.5 g).
  • 5
  • [ 56469-10-4 ]
  • [ 822-67-3 ]
  • [ 151507-23-2 ]
YieldReaction ConditionsOperation in experiment
81% With methanesulfonic acid; In dichloromethane; at 20℃; for 4h; A mixture of 5-(l,l-dimethylheptyl)-resorcinol (1,174.2 mg, 4.97 mmol), 2- cyclohexen-1-ol (690 mg, 7.03 mmol) and methanesulfonic acid (110 mg, 0.79 mmol) in 100 ml of dichloromethane (DCM) was stirred for 4 hrs at RT. The reaction progress was monitored by TLC. Upon completion of the reaction, the mixture was washed twice with a solution of saturated sodium bicarbonate and then once with brine. After phase separation and evaporation of the organic phase, the crude product was isolated and purified by column chromatography on silica gel with 20% EA in PE as the eluent. The purified 2-(2- cyclohexenyl)-5-(l , 1 -dimethylheptyl)-resorcinol was obtained at a yield of 81 %.
  • 6
  • [ 822-67-3 ]
  • [ 309947-86-2 ]
  • C21H29N5O4 [ No CAS ]
  • 7
  • [ 769-26-6 ]
  • [ 822-67-3 ]
  • 2-(cyclohex-2-en-1-yl)-1-mesitylethan-1-one [ No CAS ]
  • 8
  • [ 18698-99-2 ]
  • [ 822-67-3 ]
  • C15H15NO2 [ No CAS ]
 

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Technical Information

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[ 822-67-3 ]

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