[ CAS No. 4513-94-4 ] {[proInfo.proName]}

Name: 4513-94-4|Pyrrole-2-carbonitrile|98%
Brand: Ambeed
SKU: A208090
Price: 15.0 USD
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3d Animation Molecule Structure of 4513-94-4

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Quality Control of [ 4513-94-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 4513-94-4 ]

SDS Specification

Alternatived Products of [ 4513-94-4 ]

Product Details of [ 4513-94-4 ]

CAS No. :	4513-94-4	MDL No. :	MFCD00234061
Formula :	C₅H₄N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BQMPGKPTOHKYHS-UHFFFAOYSA-N
M.W :	92.10	Pubchem ID :	138277
Synonyms :

Calculated chemistry of [ 4513-94-4 ]

Physicochemical Properties

Num. heavy atoms :	7
Num. arom. heavy atoms :	5
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	25.51
TPSA :	39.58 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.32 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.09
Log Po/w (XLOGP3) :	0.76
Log Po/w (WLOGP) :	0.89
Log Po/w (MLOGP) :	-0.56
Log Po/w (SILICOS-IT) :	1.43
Consensus Log Po/w :	0.72

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.42
Solubility :	3.51 mg/ml ; 0.0382 mol/l
Class :	Very soluble
Log S (Ali) :	-1.17
Solubility :	6.21 mg/ml ; 0.0674 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.6
Solubility :	2.31 mg/ml ; 0.0251 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.56

Safety of [ 4513-94-4 ]

Signal Word:	Danger	Class:	9
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P362+P364-P403+P233-P501	UN#:	3082
Hazard Statements:	H302-H315-H318-H335-H410	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 4513-94-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 4513-94-4 ]
Downstream synthetic route of [ 4513-94-4 ]

[ 4513-94-4 ] Synthesis Path-Upstream 1~18

1
[ 616-47-7 ]
[ 67-66-3 ]
[ 14508-49-7 ]
[ 4513-94-4 ]
[ 17180-94-8 ]
[ 51269-82-0 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435

2
[ 4513-94-4 ]
[ 67-66-3 ]
[ 89809-64-3 ]
[ 38180-46-0 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435

3
[ 930-36-9 ]
[ 67-66-3 ]
[ 4513-94-4 ]
[ 1722-12-9 ]
[ 51269-82-0 ]

Reference： [1] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 24, p. 3581 - 3585

4
[ 616-47-7 ]
[ 67-66-3 ]
[ 14508-49-7 ]
[ 4513-94-4 ]
[ 17180-94-8 ]
[ 51269-82-0 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435

5
[ 4513-94-4 ]
[ 69807-81-4 ]

Reference： [1] Tetrahedron, 1998, vol. 54, # 10, p. 2021 - 2030

6
[ 13600-33-4 ]
[ 4513-94-4 ]
[ 7126-38-7 ]

Reference： [1] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 743 - 753

7
[ 1120-87-2 ]
[ 4513-94-4 ]
[ 7126-38-7 ]

Reference： [1] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 754 - 760

8
[ 39910-67-3 ]
[ 4513-94-4 ]
[ 7126-38-7 ]

Reference： [1] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 754 - 760

9
[ 16289-54-6 ]
[ 4513-94-4 ]
[ 51392-75-7 ]
[ 2632-99-7 ]
[ 7126-38-7 ]

Reference： [1] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 754 - 760

10
[ 10296-29-4 ]
[ 4513-94-4 ]
[ 7126-38-7 ]

Reference： [1] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 743 - 753

11
[ 16544-33-5 ]
[ 4513-94-4 ]
[ 10479-84-2 ]
[ 24442-69-1 ]
[ 33555-85-0 ]
[ 91028-12-5 ]
[ 7126-38-7 ]

Reference： [1] Journal of Organic Chemistry, 2010, vol. 75, # 5, p. 1600 - 1611

12
[ 274-87-3 ]
[ 504-29-0 ]
[ 4513-94-4 ]
[ 91028-12-5 ]
[ 7126-38-7 ]

Reference： [1] Journal of Organic Chemistry, 2008, vol. 73, # 16, p. 6265 - 6267

13
[ 5678-33-1 ]
[ 504-29-0 ]
[ 4513-94-4 ]
[ 91028-12-5 ]
[ 7126-38-7 ]

Reference： [1] Journal of Organic Chemistry, 2008, vol. 73, # 16, p. 6265 - 6267

14
[ 4513-94-4 ]
[ 67-66-3 ]
[ 89809-64-3 ]
[ 38180-46-0 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1431 - 1435

15
[ 4513-94-4 ]
[ 159326-69-9 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1429 - 1440
[2] Patent: WO2016/190847, 2016, A1,
[3] Patent: CN104003990, 2017, B,
[4] Patent: CN104974163, 2017, B,

16
[ 4513-94-4 ]
[ 136927-63-4 ]

Reference： [1] Patent: WO2007/38387, 2007, A2, . Location in patent: Page/Page column 80

17
[ 4513-94-4 ]
[ 918538-04-2 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1429 - 1440
[2] Patent: WO2016/190847, 2016, A1,
[3] Patent: CN104003990, 2017, B,
[4] Patent: CN104974163, 2017, B,

18
[ 4513-94-4 ]
[ 918538-05-3 ]

Reference： [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1429 - 1440
[2] Patent: WO2016/190847, 2016, A1,
[3] Patent: CN104003990, 2017, B,
[4] Patent: CN104974163, 2017, B,

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
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P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
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Yield	Reaction Conditions	Operation in experiment
100%		Pyrrole-2-carboxaldehyde (3.00 g, 0.0316 mole) was combined with hydroxylamine- O-sulfonic acid (12.5 g, 0.11 mole) in 100 ml water and stirred at room temperature overnight. The reaction mixture was cooled to 0C and a solution of potassium hydroxide (12.06 g, 0.603 mole) in 80ml water was added dropwise over 1 hour time period. The reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was extracted with dichloromethane (3 x 100 ml), the extract was dried over sodium sulfate (anh.). The solvent was removed to give 3.36 g of product as a liquid (yield: 100%)
100%	With hydroxylamine hydrochloride; In 1-methyl-pyrrolidin-2-one; at 125℃;	Step 10)lH-pyrrole-2-carbonitrile [0339] To a solution of lH-pyrrole-2-carbaldehyde (27.50 g, 0.29 mol) in NMP (300 mL) was added hydroxylamine hydrochloride (24.11 g, 0.35 mol). The reaction mixture was stirred at 125 C overnight, then cooled down to rt, and diluted with water (600 mL), then extracted with EtOAc (1 L x 8). The combined organic phases were dried over anhydrous Na2SC>4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/5) to give the title compound as yellow oil (26.71 g, 100%). MS (ESI, pos. ion) m/z: 93.1 [M+H]+; NMR (400 MHz, CDCb): delta (ppm) 9.27 (br. s, 1H), 6.99 (td, J = 2.7, 1.4 Hz, 1H), 6.90 (ddd, J = 3.8, 2.4, 1.4 Hz, 1H), 6.30 (dt, J= 3.6, 2.6 Hz, 1H).
100%	With 1-methyl-pyrrolidin-2-one; hydroxylamine hydrochloride; at 125℃;	1H-pyrrole-2-carbaldehyde (27.50 g, 0.29 mol) was dissolved in NMP (300 mL) and hydroxylamine hydrochloride (24.11 g, 0.35 mol) was added to the solution to obtain a reaction system. The resulting reaction was warmed to 125 C, stirred overnight and then cooled to room temperature. The reaction mixture was then diluted with water (600 mL) and extracted with ethyl acetate (1 L × 8), then the organic phases were combined. The combined organic phases were successively dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was then subjected to silica gel column chromatography (EtOAc / PE (v / v) = 1/5) to give the title compound as a yellow oil (26.71 g, 100%).

80%		To a cold solution of hydroxylamine hydrochloride (0.38 g, 5.5 mmol, 1.1 equiv.) in anhydrous acetonitrile (50 mL), triethylamine (0.77 mL, 5.5 mmol, 1.1 equiv.) and 1H-pyrrole-2-carboxaldehyde (5.0 mmol, 1.0 equiv.) were added and stirred for around 30 mins. Then phthalic anhydride (0.75 g, 5.05 mmol, 1.01 equiv.) was slowly added under nitrogen protection. The resulting mixture was stirred at 80 C for about 8 h. After concentration, the resulting residue was added cold CH2Cl2 (30 ml × 3) and stirred. The combined filtrates were washed with 5% ammonia water to remove phthalic acid completely. The separated organic layer was dried over anhydrous Na2SO4, and then concentrated under reduced pressure. Finally the residue was purified by passing it through a short silica gel column using CHCl3 as eluent to give pure 1H-pyrrole-2-carbonitrile as yellow oil (80%).3 A mixture of 1H-pyrrole-2-carbonitrile (3.0 mmol, 1.0 equiv.), substituted methyl bromide (3.3 mmol, 1.1 equiv.) and K2CO3 (3.6 mmol, 1.2 equiv.) was stirred in CH3CN (20 mL) at room temperature. After being stirred for 12 h, the reaction mixture was concentrated under reduced pressure, diluted with EtOAc (30 mL), and washed with H2O (30 mL). The water layer was extracted with EtOAc (30 mL) one more time. The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The resulting residue was purified by column chromatography (hexane: EtOAc = 10:1) to afford 1b as white solid.
70%	With hydroxylamine hydrochloride; In 1-methyl-pyrrolidin-2-one; at 110 - 115℃;	Pyrrole-2-carbaldehyde (10 mmol), NMP (15 mL), and NH2OH·HCl (12 mmol) were refluxed at 110-115 C. After cooling to room temperature, H2O (50 mL) was added. The mixture was then extracted with ethyl acetate (3 × 20 mL), dried over MgSO4, and filtered. After evaporation of the solvent, the crude product was purified by flash column chromatography (EtOAc/hexane, 1:6) to give compound 2 in 70% yield; bp: 92-94 C; Rf: 0.70 (EtOAc/Hex, 1:3); 1H NMR (400 MHz, CDCl3) delta (ppm) 6.18 (br s, 1H) 6.80 (br s,1H) 6.94 (br ss, 1H) 9,43 (s, 1H); 13C NMR (100 MHz, CDCl3) delta (ppm) 100.41, 110.29, 115.08, 120.64, 124.11.

Yield	Reaction Conditions	Operation in experiment
83%		A solution of IH-<strong>[4513-94-4]pyrrole-2-carbonitrile</strong> (10.0 g, 109 mmol) in tetrahydrofuran (100mL) was cooled to 0 C and treated portion-wise with sodium hydride (60% in mineraloil, 6.3 g, 160 mmol. The resulting mixture was stirred at 0 C for 30 minutes, whereupon 2-(trimethylsilyl)ethoxymethyl chloride (27.0 g, 162 mmol) was added, and the reaction mixture was allowed to warm to room temperature. After 2 hours, it was quenched with saturated aqueous sodium chloride solution (100 mL). The organic layerwas dried over sodium sulfate, filtered, and concentrated in vacuo; silica gelchromatography (Fluent: 5:1 petroleum ether ethyl acetate) afforded the product as acolorless oil. Yield: 20 g, 90 mmol, 83%. 1H NMR (400 MHz, CDCI3) oe 7.00 (dd, J=2.8,1.6 Hz, IH), 6.85 (dd, J=3.9, 1.6 Hz, IH), 6.25 (dd, J=3.9, 2.8 Hz, IH), 5.36 (s, 2H),3.51 -3.57 (m, 2H), 0.89-0.96 (m, 2H), -0.01 (5, 9H).
550 mg		To a solution of <strong>[4513-94-4]1H-<strong>[4513-94-4]pyrrole-2-carbonitrile</strong></strong> (300.00 mg, 3.26 mmol, 1.00 eq) in THF (2.00 mL) was added batchwise NaH (195.44 mg, 4.89 mmol, 60% purity, 1.50 eq) at 0 C. After addition, the mixture was stirred at this temperature for 30 min, and then 2-(chloromethoxy) ethyltrimethylsilane (814.59 mg, 4.89 mmol, 866.59 uL, 1.50 eq) was added dropwise at 0 C. The resulting mixture was stirred at 20 C for 1 h. The reaction mixture was quenched with H2O (20 mL), and extracted with EtOAc (10 mL3). The combined organic layers were washed with brine (50 mL2), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, PE/EtOAc=20:1 to 10:1) to afford the title compound (550 mg) as a yellow oil.

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 4513-94-4 ] {[proInfo.proName]}

Quality Control of [ 4513-94-4 ]

Related Doc. of [ 4513-94-4 ]

Product Details of [ 4513-94-4 ]

Calculated chemistry of [ 4513-94-4 ]

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Lipophilicity

Druglikeness

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Medicinal Chemistry

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Application In Synthesis of [ 4513-94-4 ]

[ 4513-94-4 ] Synthesis Path-Upstream 1~18

[ 4513-94-4 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 4513-94-4 ]

Nitriles

Related Parent Nucleus of [ 4513-94-4 ]

Pyrroles

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[ 4513-94-4 ]

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[ 4513-94-4 ]