Structure of 4559-70-0
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CAS No. : | 4559-70-0 |
Formula : | C12H11OP |
M.W : | 202.19 |
SMILES Code : | O=P(C1=CC=CC=C1)C2=CC=CC=C2 |
MDL No. : | MFCD00002079 |
InChI Key : | YFPJFKYCVYXDJK-UHFFFAOYSA-N |
Pubchem ID : | 6327869 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 14 |
Num. arom. heavy atoms | 12 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 2 |
Num. H-bond acceptors | 1.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 61.15 |
TPSA ? Topological Polar Surface Area: Calculated from |
40.54 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.82 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
3.56 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
2.2 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
2.73 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
4.57 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
2.98 |
Log S (ESOL):? ESOL: Topological method implemented from |
-3.84 |
Solubility | 0.0293 mg/ml ; 0.000145 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-4.1 |
Solubility | 0.0162 mg/ml ; 0.00008 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-4.94 |
Solubility | 0.00234 mg/ml ; 0.0000116 mol/l |
Class? Solubility class: Log S scale |
Moderately soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
Yes |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-5.01 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<2.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
3.77 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
41% | With palladium on activated charcoal; potassium carbonate; In water; at 180℃; for 1h;Microwave irradiation; | Standard conditions: iodobenzoic acid (0.55 mmol) , HP(0)Ph2, base, Pd/C, 0 (10 mL) , conventional heating, 100 C, 1 h. b 70 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With triphenylborane; In 1,4-dioxane; diethyl ether; at 27℃; for 22h;Inert atmosphere; | EXAMPLE 8In a reactor equipped with nitrogen inlet, condensationtube andthermometer, 80.8 g (0.4 mol) of diphenyl phosphine oxide (DPPO) and 31.55 g (0.05 mol) of <strong>[69655-76-1]octavinyl cyclooctasilsesquioxane</strong> were sequentially added into 180 ml of 1,4- dioxane, and stirred to be clear and transparent at 27° C., 240 ml 0.2M of solution of triphenyl boron in ethyl ether was dropwise added in 6 hours at the maintained temperature27° C. under nitrogen protection; afier the completiondropwise addition, the reaction was kept at 27°C. for 16 hours before it was stopped, evaporating the solvent, washing with water several times, and drying, thereby obtaining 105.33 gthe white solid (compound 5), yield 94percent.The structural test datum of this compound are shownfollows (nuclear magnetic hydrogen spectrogram, nuclear magnetic carbon spectrogram, nuclear magnetic phosphorus spectrogram, nuclear magnetic silicon spectrogram, massspectrogram (MALDI-TOF), infrared spectrogram and DSCspectrogram of this compound are shown as in Examplerespectively):melting point: 257-261° C. (DSC peak temperature). nuclear magnetic hydrogen spectrum (CDC13, 400 Hz, ppm): 0.87 (m, 16H), 2.28 (d, 16H), 7.37 (m, 32H), 7.42 (m, 16H), 7.61 (m, 32H).nuclear magnetic carbon spectrum (CDC13, 400 Hz, ppm):132.5, 131.79, 131.53, 130.7, 128.8, 22.69.nuclear magnetic phosphorus spectrum (CDC13, 300 Hz, ppm): 32.76.nuclear magnetic silicon spectrum (CDC13, 300 Hz, ppm):?66.72.mass spectrum (MALDI-TOF): 2271, (M+Naj. elementary analysis (percent): theoretical value, C, 59.77; H, 5.02; measured value, C, 59.46; H, 5.11.infrared spectrum (cm?): 3067, 3026, 2987, 2961, 1946, 1604, 1410, 1276, 1111, 1005, 970.structural formula is shown as in Example 7. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35.5% | With copper(l) iodide; caesium carbonate; L-proline; In toluene; for 24h;Reflux; | A mixture of tris-(4-iodo-phenyl)-amine (1.0 mmol), diphenylphosphine oxide (3.6 mmol), CuI (0.30 mmol), proline (0.30 mmol), and Cs2CO3 (4.5 mmol) was added to toluene solution (20 mL). The mixture was heated under reflux for 36 h. After the reaction finished, the reaction mixture was extracted with dichloromethane and washed with water. The organic layer was dried by anhydrous MgSO4 and filtered. The product was isolated by silica gel column chromatography using methanol/ethyl acetate (1:5) as eluent to afford an oyster white solid (0.30 g, 35.5percent). 1H NMR (300 MHz, CDCl3, TMS) delta: 7.71 (d, J=8.2 Hz, 4H), 7.67 (t, J=6.9 Hz, 4H), 7.60-7.37 (m, 16H), 7.31-7.26 (m, 6H), 7.14 (t, J=7.2 Hz, 8H), 7.02-6.98 (m, 4H); C NMR (CDCl3, delta): 133.8, 133.7, 133.2, 132.1, 132.0, 128.7, 128.5, 127.7, 124.1, 124.0; MS (MALDI-TOF) [m/z]: calcd for C54H42NO3P3, 845.8; found, 845.4. Anal. Calcd for C54H42NO3P3: C, 80.88; H, 5.43; N 3.14. Found: C, 80.66; H, 5.32; N 3.25. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With copper(l) iodide; (S)-1-phenyl-ethylamine; potassium carbonate; In toluene; at 110℃; for 24h;Inert atmosphere; | General procedure: 4.2.1 Diphenyl(o-tolyl)phosphine oxide (6a) Prepared using the general procedure from diphenylphosphine oxide (5a) (0.202 g, 1 mmol) and o-iodotoluene (0.127 mL, 1 mmol): yield 0.254 g (87%); white solid; mp 121.5-122.9 C (lit. 31 121-123 C); Rf (CHCl3/MeOH=15:1) 0.68; [found: C, 78.35; H, 5.95. C19H17OP requires C, 78.07; H, 5.86]; νmax (ATR) 3491, 3445, 3061, 2925, 1590, 1433, 1311, 1281, 1178, 1118, 1102, 764, 703, 694; δH (500 MHz, CDCl3) 2.45 (s, 3H, Me), 7.00-7.05 (m, 1H), 7.10-7.15 (m, 1H), 7.26-7.30 (m, 1H), 7.39-7.44 (m, 1H) 7.45-7.49 (m, 4H) 7.52-7.57 (m, 2H) 7.62-7.68 (m, 4H); δC (125 MHz, CDCl3) 21.6 (d, JP-C=5.4 Hz), 125.1 (d, JP-C=12.7 Hz), 128.5 (d, JP-C=12.7 Hz), 130.7 (d, JP-C=103.5 Hz), 131.7 (d, JP-C=2.7 Hz), 131.8 (d, JP-C=10.0 Hz), 132.0 (d, JP-C=2.7 Hz), 132.6 (d, JP-C=102.6 Hz), 133.4 (d, JP-C=12.4 Hz), 143.2 (d, JP-C=8.2 Hz); δP (202 MHz, CDCl3) 31.82; GC tR=21.34 min; GC-MS (EI, 70 eV) m/z=292 (M+) (21), 291 (62), 278 (34), 277 (100), 201 (15), 199 (26), 183 (19), 165 (12), 152 (18); HRMS [M+H]+: calcd for C19H18OP: 293.1090. Found: 293.1086; Analytical data are in accordance with those reported in the literature. 31 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With copper(l) iodide; caesium carbonate; L-proline; In toluene; at 110℃;Inert atmosphere; | A mixture of <strong>[626-44-8]1,3,5-triiodobenzene</strong> (0.46 g, 1.0 mmol), diphenylphosphine oxide (0.73 g, 3.6 mmol), CuI (0.06 g, 0.30 mmol), l-proline (0.04 g, 0.30 mmol), and Cs2CO3 (1.5 g, 4.5 mmol) was added to toluene solution (30 mL). The mixture was refluxed under nitrogen for 48 h. After the reaction finished, the reaction mixture was extracted with dichloromethane and washed with water. The organic layer was dried by anhydrous MgSO4 and filtered. The product was isolated by silica gel column chromatography using methanol/ethyl acetate (1:5) as eluent to afford a white solid (0.64, 52%). 1H NMR (300 MHz, CDCl3, delta): 8.08 (t, J = 11.9 Hz, 3H), 7.52 (dd, J = 12.9, 7.2 Hz, 18H), 7.39 (dd, J = 9.8, 4.8 Hz, 12H). 13C NMR (75 MHz, CDCl3, delta): 141.05, 141.02, 140.91, 134.89, 134.66, 134.39, 133.00, 131.36, 131.19, 31P NMR (121 MHz, CDCl3, delta): 27.59. HRMS [m/z]: calcd for C42H33O3P3, 678.1643; found, 679.1711 [M+H+]. Anal. Calcd. for C42H33O3P3: C, 74.33; H, 4.90. Found: C, 74.36; H, 4.88. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | In tetrahydrofuran; at 80℃; for 4h;Inert atmosphere; Sealed tube; | General procedure: Under N2, a 20 mL Schlenk tube equipped with a stir bar was charged with diphenylphosphine oxide 1 (0.2 mmol), diphenyl sulfide 2 (0.2 mmol), THF (2.0 mL). The tube was sealed with a Teflon cap. The reaction mixture was stirred at 80 C for 4 h in oil bath. After the completion of the reaction (monitored by TLC), the reaction mixture was concentrated in vacuum and the residue was purified by flash column chromatography on silica gel with petroleum ether-EtOAc as the eluent to give the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium tert-butylate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In 1,4-dioxane; at 120℃; for 16h;Inert atmosphere; Glovebox; Schlenk technique; | Method 1: Under a nitrogen atmosphere, in a glove box, Add 0.02 mmol of Pd2(dba)3·HCCl3 (tris(dibenzylideneacetone)dipalladium·chloroform), 0.04 mmol of tBuDavePhos. (2-di-tert-butylphosphonium-2-(N,N-dimethylamino)biphenyl) or 2-di-tert-butylphosphine-2'-(N,N-dimethylamino)-1,1'-biphenyl, 0.52 mmol of diphenylphosphine oxide, 1.5 equivalents of t-BuOK (potassium tert-butoxide), Adding to the Schlenk reaction tube in turn, then adding 0.4 mmol of 3,4,5-trimethoxybenzyl nitrile compound, vacuuming and backfilling with nitrogen; Under a nitrogen atmosphere, a solvent of 3 ml of 1,4-dioxane was added, and the reaction was continued at 120 C for 16 h. After the reaction is completed, it is cooled to room temperature and separated by column chromatography. The target product was obtained: 3,4,5-trimethoxybenzyldiphenylphosphine oxide in a yield of 96%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With potassium tert-butylate; nickel(I) chloride; In 1,4-dioxane; at 120℃; for 16h;Inert atmosphere; Glovebox; Schlenk technique; | In the glove box, 0.01 mmol of nickel chloride was added, 0.52 mmol of diphenylphosphine oxide, 1.5 equivalents of t-BuOK (potassium tert-butoxide),Add to the Schlenk reaction tube in turn, then Add 0.4mmol 1, 1-diphenylpropionitrile compound, Vacuum and backfill nitrogen; under a nitrogen atmosphere, add 3 ml of 1,4-dioxane to the solvent. The reaction was continued at 120 C for 16 h. After the reaction is completed, it is cooled to room temperature and separated by column chromatography. That is the target product: 1,1-diphenylethyldiphenylphosphine oxide, yield 87%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 120℃; for 7h;Schlenk technique; Inert atmosphere; | General procedure: An oven-dried Schlenk flask was evacuated and back-filled with argon three times. (Hetero)aryl (di)halide (1 equiv), base (1.5 equiv per halogen) and a solution of SPO (1.2 equiv per halogen) in anhydrous solvent (5 mL/mmol per halogen) were added to the flask. The solution was bubbled with argon for 10 min and Pd(OAc)2 (1 molpercent per halogen) and ferrocene-based bidentate phosphine ligand (2 molpercent per halogen) were added to the flask simultaneously [2.5 molpercent Pd(OAc)2 per halogen and 5 molpercent dppf per halogen for compounds 2j, 2l, 2r, 2t, 2w]. The resulting mixture was heated at the indicated temperature for the given time. Workup procedures are described below for two different conditions. Final purification of crude products was achieved by column chromatography on silica gel (40?60 mum) using CH2Cl2?MeOH as eluent. Reaction scale and yields are shown in Table 1 (2a?w), Scheme 1 (3a?h) and Scheme 2 (4a?g). Notice that all compounds with two phosphine oxide groups are beige-to-brown solids or slowly solidifying viscous brown oils. Conditions I: ligand: dppf, solvent: DMF, base: Cs2CO3 (2d?n, 2q, 2r, 2t?w, 4a?g) or K2CO3 (3a?h), temperature: 120 °C, time: 7 h (20 h for 2j, 2l, 2r, 2w). Workup: after cooling, the reaction mixture was poured into a fourfold excess of brine. The mixture was extracted three times with CH2Cl2 (40 mL/mmol each). The combined organic layers were washed with brine to remove traces of DMF, dried over Na2SO4 and then evaporated to dryness. Conditions II: ligand: dippf, solvent: toluene, base: t-BuOK, temperature: 110 °C, time: 7 h. Workup: after cooling, the reaction mixture was evaporated to dryness. Then, the mixture was diluted with CH2Cl2 (40 mL/mmol) and washed with water and brine (40 mL/mmol). The organic layer was dried over Na2SO4 and the CH2Cl2 was removed under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With dipotassium peroxodisulfate; silver(l) oxide; In acetone; at 35℃; | Add 4-iodophenylacetic acid (131 mg, 0.5 mmol), diphenylphosphine (101 mg, 0.5 mmol), potassium persulfate (270 mg, 1.0 mmol), and silver oxide (10 mg, 0.08 mmol) to the reaction flask. ) And acetone (5 mL), 35 oC;TLC follows the reaction to completion;The crude product obtained after the reaction was separated by column chromatography (dichloromethane: methanol = 95: 5) to obtain the target product (yield 77%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With di-tert-butyl dicarbonate; N,N-dimethyl-cyclohexanamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In 1,4-dioxane; at 115℃; for 18.0h;Schlenk technique; Inert atmosphere; Glovebox; | Weigh 1.2 times the equivalent of <strong>[6223-83-2]9-oxo-9H-fluorene-4-carboxylic acid</strong> (0.48 mmol),Take 1.0 times equivalent of diphenylphosphine (HP (O) Ph2) and 10 mol% Pd (OAc) 2, 10 mol% dppp, 2.0 times equivalent CyNMe2, in glove box.1.4 times the equivalent of Boc2O was added to the Schlenk reaction tube in turn, and then, under a nitrogen atmosphere,3 ml of dioxane solvent was added, and the reaction was continued at 115 C for 18 h.After the reaction, it was cooled to room temperature and separated by column chromatography to obtain the target product:4- (diphenylphosphoryl) -9H-fluorene-9-one,The yield was 70%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | General procedure: An oven-dried, 10 mL two-neck glass tube was equipped with a magnetic stir bar, a rubber septum, a Teflon cap fitted with electrical feed-throughs, a carbon felt anode (1.0 × 0.5 cm2) (connected to the electrical feed through via a 9 cm in length, 2 mm in diameter graphite rod), and a platinum foil cathode (0.5 × 1.0 cm2). To this reaction vessel, bipy (1.9 mg, 0.012 mmol, 6 mol%), Mn(OTf)2 (3.6 mg, 0.01 mmol, 5 mol%), phosphorous source (0.2 mmol, 1.0 equiv), and lithium chloride (17.0 mg, 0.4 mmol, 2.0 equiv) was added. The cell was sealed, 3 mL of electrolyte solution (0.10 M LiClO4 in acetonitrile) were added, and the mixture was flushed with nitrogen gas for 5 minutes, followed by the addition via syringe of a mixture of olefin substrate (0.2 mmol,1.0 equiv), 0.5 mL electrolyte solution, and acetic acid (0.40 mL). A nitrogen-filled balloon was adapted through the septum to sustain a nitrogen atmosphere. Electrolysis was initiated at a constant cell voltage of 2.3 V at 22 C. Reaction was stopped after 3.0 F charge was passed. The entire reaction mixture was then transferred to a short silica gel column (7-10 cm in length, ca. 10g) and flushed through with 100 mL of 1:1 mixture of hexanes and acetone to eliminate the inorganic salts, and the product solution was concentrated in vacuo. The residue was subjected to flash column chromatography on silica gel (eluted with hexanes/ethyl acetate) to yield the pure product. |
Tags: 4559-70-0 synthesis path| 4559-70-0 SDS| 4559-70-0 COA| 4559-70-0 purity| 4559-70-0 application| 4559-70-0 NMR| 4559-70-0 COA| 4559-70-0 structure
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P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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