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Chemical Structure| 51052-78-9 Chemical Structure| 51052-78-9

Structure of 51052-78-9

Chemical Structure| 51052-78-9

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Product Details of [ 51052-78-9 ]

CAS No. :51052-78-9
Formula : C7H13NO2
M.W : 143.18
SMILES Code : O=C(O)CC1CCNCC1
MDL No. :MFCD02093097

Safety of [ 51052-78-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 51052-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 51052-78-9 ]
  • Downstream synthetic route of [ 51052-78-9 ]

[ 51052-78-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 501-53-1 ]
  • [ 51052-78-9 ]
  • [ 63845-28-3 ]
YieldReaction ConditionsOperation in experiment
86% With H2; sodium hydroxide In water A.
1-[(Phenylmethoxy)carbonyl]-4-piperidineacetic acid
Platinum oxide (300 mg, Alfa) was added to a solution of pyridyl-4-acetic acid, hydrochloride (3.3 g, 19 mmol) in water (120 mL).
The solution was hydrogenated at up to 50 psi of H2 pressure for 17 hrs.
The catalyst was removed by filtration through a pad of Celite and the pad was washed with more water.
The stirred aqueous solution of the piperidine-4-acetic acid was cooled (0°-5° C.) and treated with 5 N aqueous NaOH solution (15 mL) to pH 12.
Benzyl chloroformate (4 mL) was added dropwise to the vigorously stirred cooled solution.
After one hour (maintaining the pH at 10 to 12), the reaction mixture was extracted with ether (2*100 mL).
The ether extracts were discarded and the aqueous layer was acidified with 2 N HCl solution (50 mL).
The acidified aqueous layer was then extracted with ethyl acetate (2*75 mL).
The combined extracts were dried over magnesium sulfate and concentrated in vacuo to give title compound as a white solid (4.53 g, 86percent yield).
References: [1] Patent: US5583146, 1996, A, .
 

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