521286-38-4|2-((tert-Butoxycarbonyl)amino)pentanoic acid| Ambeed

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Quality Control of [ 521286-38-4 ] Purity: 95% SDS Specification

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Product Details of [ 521286-38-4 ]

CAS No. :	521286-38-4
Formula :	C₁₀H₁₉NO₄
M.W :	217.26
SMILES Code :	CCCC(C(O)=O)NC(OC(C)(C)C)=O
MDL No. :	MFCD00270725
InChI Key :	INWOAUUPYIXDHN-UHFFFAOYSA-N
Pubchem ID :	302433

Safety of [ 521286-38-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 521286-38-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 521286-38-4 ]

[ 521286-38-4 ] Synthesis Path-Downstream 1~35

1
[ 65253-04-5 ]
[ 521286-38-4 ]
[ 135263-89-7 ]
[ 145308-95-8 ]

References: [1]Tetrahedron,1992,vol. 48,p. 5163 - 5178.

2
[ 521286-38-4 ]
[ 543-27-1 ]
Boc-DL-Nva-O-CO-O-iBu [ No CAS ]

References: [1]Tetrahedron,1995,vol. 51,p. 7361 - 7372.
[2]Journal of Medicinal Chemistry,2021,vol. 64,p. 15912 - 15935.

3
[ 4530-18-1 ]
[ 103-71-9 ]
[ 521286-38-4 ]
[ 501-52-0 ]
C₄₄H₅₀N₆O₃ [ No CAS ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 5441 - 5446.

4
[ 6638-79-5 ]
[ 521286-38-4 ]
[ 521286-49-7 ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: To a solution of 2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid (CAS 102185-35-3, 500 mg, 2.16 mmol) in DCM (5 mL) was added N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (497 mg, 2.59 mmol) and stirred for 10 minutes at rt. A solution of N,O-dimethylhydroxylamine hydrochloride (253 mg, 2.59 mmol) and DIPEA (0.429 mL, 2.59 mmol) in DCM (5 mL) was added and the reaction mixture was left to stir at rt over weekend. The mixture was diluted with DCM (30 mL) and extracted with saturated aqueous NaHCO3 (50 mL). The organic phase was washed with water before being dried over MgSO4 and evaporated to give the title compound (466 mg, 79%).

References: [1]Chemistry - A European Journal,2021,vol. 27,p. 2483 - 2492.
[2]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 1628 - 1632.
[3]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 5485 - 5492.

5
[ 521286-38-4 ]
[ 166196-06-1 ]