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Chemical Structure| 65253-04-5 Chemical Structure| 65253-04-5

Structure of 65253-04-5

Chemical Structure| 65253-04-5

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Product Details of [ 65253-04-5 ]

CAS No. :65253-04-5
Formula : C16H24O
M.W : 232.36
SMILES Code : O[C@H]1[C@H](C(C)(C2=CC=CC=C2)C)CC[C@@H](C)C1
MDL No. :MFCD00010501
InChI Key :WTQIZFCJMGWUGZ-BPLDGKMQSA-N
Pubchem ID :2725001

Safety of [ 65253-04-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 65253-04-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65253-04-5 ]

[ 65253-04-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 65253-04-5 ]
  • [ 521286-38-4 ]
  • [ 135263-89-7 ]
  • [ 145308-95-8 ]
  • 2
  • [ 16957-70-3 ]
  • [ 65253-04-5 ]
  • [ 313070-57-4 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; aqueous KOH; Example 8 Preparation of (-)-8-Phenylmenthyl trans-2-Methyl-2-pentenoate To a 50-mL round-bottomed flask <strong>[16957-70-3]trans-2-methyl-2-pentenoic acid</strong> (2.2 g, 19.3 mmol) and thionyl chloride (5 mL, 58 mmol) were added. Bubbles evolved from the light yellow solution immediately. The mixture was stirred at room temperature for 5 min and then heated at reflux for 30 min. Unreacted thionyl chloride was removed by heating the mixture in an oil bath at 160° C. (-)-8-Phenylmenthol (Aldrich, 0.95 g, 4.1 mmol) was added to the acyl chloride and the mixture was heated in an oil bath at 190° C. for 30 min. Dilute aqueous KOH solution was added into the mixture and the product was extracted with ether. Evaporation of ether provided a light brown oil which is further purified by column chromatography (silica gel, hexanes:ether=50:1) to give a light yellow oil, 1.28 g; yield: 94.8percent. 1H NMR showed that it was the desired product, but contained some cis isomer, the trans:cis ratio being 5:1.
 

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