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Chemical Structure| 52333-90-1 Chemical Structure| 52333-90-1

Structure of 52333-90-1

Chemical Structure| 52333-90-1

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Product Details of [ 52333-90-1 ]

CAS No. :52333-90-1
Formula : C12H9N3O
M.W : 211.22
SMILES Code : NC1=CC=CC(C2=NC3=NC=CC=C3O2)=C1
MDL No. :MFCD00606406
InChI Key :HKWQPWPKROMXCJ-UHFFFAOYSA-N
Pubchem ID :611086

Safety of [ 52333-90-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 52333-90-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52333-90-1 ]

[ 52333-90-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 52333-90-1 ]
  • [ 52334-92-6 ]
  • [ 3616-56-6 ]
  • [ 52334-50-6 ]
YieldReaction ConditionsOperation in experiment
With sodium borohydrid; In ethanol; water; EXAMPLE 269 2-[3-(2-Dimethylaminoethyl)aminophenyl]oxazolo[4,5-b]pyridine A mixture of 1.1 g., (0.005 mole) of 2-(3-aminophenyl)oxazolo[4,5-b]pyridine and 50 ml. of ethanol is reacted with dimethylaminoacetaldehyde [from 0.96 g. (0.006 mole) dimethylaminoacetaldehyde diethylacetal]by gentle heating to complete the intermediate Schiff base formation. The mixture is then cooled and 60 mg., (0.0015 mole) of sodium borohydride is added, and the mixture allowed to stir overnight at room temperature. Water is added, the solvents are removed in vacuo, and the residue is distributed between water and methylene chloride. The organic layer is dried and concentrated in vacuo to give crude 2-[3-(2-dimethylaminoethyl)aminophenyl]oxazolo[4,5-b]pyridine, purified via column chromatography using an alumina column with an ethylacetate-ether mixture (v/v 0-60percent ethylacetate) as eluant.
  • 2
  • [ 52333-90-1 ]
  • [ 3973-08-8 ]
  • [ 1448806-56-1 ]
YieldReaction ConditionsOperation in experiment
20% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20℃;Ionic liquid; General procedure: To a solution of the benzoxazole core (1.0 eq) in DMF (10 mL/mmol of limiting reagent) was added the carboxylic acid (1.2 eq), HBTU (1.2 eq) and triethylamine (5.0 eq). The solution was stirred under nitrogen at 45 °C overnight. The solution was extended with ethyl acetate, a saturated solution of sodium bicarbonate was added and the mixture was extracted three times with ethyl acetate. The combined organic layers were then washed with brine, dried with sodium sulphate and the solvent was removed in vacuo. Purification by column chromatography on silica gel, eluting ethyl acetate/cyclohexane 50:50 led to the desired carboxamide.
  • 3
  • [ 52333-90-1 ]
  • [ 1643-16-9 ]
  • 2-(4-isopropylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide [ No CAS ]
 

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