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CAS No. : | 5443-49-2 | MDL No. : | MFCD00006965 |
Formula : | C9H7BrO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | WQRWNOKNRHCLHV-TWGQIWQCSA-N |
M.W : | 211.06 | Pubchem ID : | 5369403 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 | UN#: | N/A |
Hazard Statements: | H302-H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(mesityl)imidazolium chloride In tetrahydrofuran at 20℃; Inert atmosphere | General procedure: To a stirred suspension of IMes*HCl (9 mg, 0.025 mmol) in anhyd THF (2 mL) was added DBU (0.6 mmol, 88 μL) via micro syringe under N2. After the mixture was stirred at room temperature for 30 min, α-halo-α,β-unsaturated aldehyde (0.5 mmol) and alcohol (1.5 mmol) were loaded, the reaction mixture was then stirred at room temperature until full consume of the starting aldehyde indicated by TLC. After concentration of the mixture under vacuum, the crude product was purified through flash column chromatography (silica gel, PE/EtOAc, 10:1-15:1) to give desired product. |
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