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Chemical Structure| 56-84-8 Chemical Structure| 56-84-8
Chemical Structure| 56-84-8

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L-aspartic Acid is a non-essential amino acid that involved in the urea cycle, citric acid cycle and in DNA metabolism, it can be used as a suitable prodrug and to study non-enzymatic gluconeogenesis.

Synonyms: L-Aspartic acid

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Product Citations

Product Citations

Yangfeng Li ; Zhengnan Shen ; Kiira Ratia ; Jiong Zhao ; Fei Huang ; Oleksii Dubrovyskyii , et al.

Abstract: The bromodomain and extra-terminal domain (BET) proteins are epigenetic readers, regulating transcription via two highly homologous tandem bromodomains, BD1 and BD2. Clinical development of nonselective pan-BD BET inhibitors has been challenging, partly due to dose-limiting side effects such as thrombocytopenia. This has prompted the push for domain-selective BET inhibitors to achieve a more favorable therapeutic window. We report a structure-guided drug design campaign that led to the development of a potent BD1-selective BET inhibitor, 33 (XL-126), with a Kd of 8.9 nM and 185-fold BD1/BD2 selectivity. The high selectivity was first assayed by SPR, validated by a secondary time-resolved fluorescence energy transfer assay, and further corroborated by BROMOscan (∼57–373 fold selectivity). The cocrystal of 33 with BRD4 BD1 and BD2 demonstrates the source of selectivity: repulsion with His437 and lost binding with the clamp. Notably, the BD1 selectivity of BET inhibitor 33 leads to both the preservation of platelets and potent anti-inflammatory efficacy.

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Product Details of H-Asp-OH

CAS No. :56-84-8
Formula : C4H7NO4
M.W : 133.10
SMILES Code : N[C@@H](CC(O)=O)C(O)=O
Synonyms :
L-Aspartic acid
MDL No. :MFCD00002616
InChI Key :CKLJMWTZIZZHCS-REOHCLBHSA-N
Pubchem ID :5960

Safety of H-Asp-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-Asp-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 56-84-8 ]
  • Downstream synthetic route of [ 56-84-8 ]

[ 56-84-8 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 50720-05-3 ]
  • [ 56-84-8 ]
  • [ 2456-73-7 ]
References: [1] Journal of Organic Chemistry, 1958, vol. 23, p. 1776.
  • 2
  • [ 87-51-4 ]
  • [ 56-84-8 ]
  • [ 2456-73-7 ]
References: [1] Journal of Biological Chemistry, 2018, vol. 293, # 46, p. 17731 - 17738.
  • 3
  • [ 56-84-8 ]
  • [ 100-51-6 ]
  • [ 6327-59-9 ]
References: [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6220 - 6229.
 

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