[ CAS No. 5637-42-3 ] {[proInfo.proName]}

Name: 5637-42-3|1-(4-Cyanophenyl)guanidine|97%
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Quality Control of [ 5637-42-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 5637-42-3 ]

CAS No. :	5637-42-3	MDL No. :	MFCD16251323
Formula :	C₈H₈N₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BTDGLZSKNFJBER-UHFFFAOYSA-N
M.W :	160.18	Pubchem ID :	17747914
Synonyms :

Safety of [ 5637-42-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 5637-42-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5637-42-3 ]
Downstream synthetic route of [ 5637-42-3 ]

[ 5637-42-3 ] Synthesis Path-Upstream 1~2

1
[ 420-04-2 ]
[ 873-74-5 ]
[ 5637-42-3 ]

Yield	Reaction Conditions	Operation in experiment
33 g	Stage #1: With nitric acid In ethanol; water for 16 h; Reflux Stage #2: With sodium hydroxide In water	A solution of P-aminobenzonitrile (100 gm), ethanol (500 ml), concentrated nitric acid (36 ml) and aqueous cyanamide (50percent, 54 ml) was heated at reflux. The solution was maintained for 16 hours at reflux. The reaction mass was further cooled to 0° C. and then added methyl tert-butyl ether (500 ml) at 0 to 5° C. The reaction mass was maintained for 5 hours at 0 to 5° C. and separated solid obtained was collected by filtration to obtain 59 gm of guanidine nitrate. Guanidine nitrate (59 gm) was dissolved in water (590 ml) and then added sodium hydroxide solution (1M, 325 ml). The separated solid obtained was filtered and dried to obtain 33 gm of 1-(4-cyanophenyl)guanidine.
30 g	With nitric acid In methanol; water at 10 - 65℃; for 8 h;	100 g of 4-aminobenzonitrile was dissolved in 500 mL of methanol and cooled the reaction mixture to 10-15° C. 161 mL of con. Nitric acid was added to the reaction mixture followed by 65.6 ml of 50percent aqueous solution cynamide to the reaction mixture and maintained the reaction at 65° C. for 8 hrs. Cooled the reaction mass to 0° C. and charged 500 ml of methyl-t-butyl ether at 0° C. The solids were filtered, washed with water and acetone and dried to give 30 g of the product as a solid.

Reference： [1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 1, p. 244 - 255
[2] Patent: WO2012/1695, 2012, A1, . Location in patent: Page/Page column 10
[3] Patent: US2013/96148, 2013, A1, . Location in patent: Paragraph 0085; 0086
[4] Patent: US2015/336900, 2015, A1, . Location in patent: Paragraph 0027; 0028

2
[ 5637-42-3 ]
[ 1398507-08-8 ]

Reference： [1] Patent: WO2012/147104, 2012, A1,
[2] Patent: US2013/116433, 2013, A1,

[ 5637-42-3 ] Synthesis Path-Downstream 1~20

1
[ 5637-42-3 ]
[ 87-13-8 ]
4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75.9%		Example 2A mixture of 64 g (0.4 mol) of <strong>[5637-42-3](4-cyanophenyl)guanidine</strong>, 98.4 g (1.2 mol) sodium acetate and 76.6g (0.44 mol) diethyl(ethoxymethylene)malonate in 600 ml N-methylpyrrolidinone (NMP) was heated to 100C and stirred for 1 hour at that temperature. 81 ml of demineralized water was added and the reaction mixture was further heated to reflux temperature. About 120 ml of the solvent was evaporated until the temperature of the reaction mixture reached the range of 155C to 160C. Subsequently the reaction mixture was refluxed during 72 hours. The whole is allowed to cool to 20-25C and 25g filtration aid was added. After stirring the mixture for 1 hour at 20-25C, the precipitate was filtered off and washed with 50 ml of NMP. The solvent was distilled off under vacuum and the residue was heated to 130C. 375 ml acetic acid was added dropwise (during 15 minutes) to the heated residue while keeping the temperature at 130C. After addition of the acetic acid, the mixture was heated to 150C and stirred at EPO <DP n="11"/>that temperature for 15 minutes. Subsequently, the mixture was allowed to cool to 20-25C. The formed precipitate was filtered off and washed with ethanol (1 x 250 ml and 1 x 100ml). 500ml ethanol was added to the washed precipitate and this mixture was heated and refluxed for 1 hour. After cooling to 20-25C, the precipitate was filtered off, washed with 100 ml ethanol and dried at 50C under vacuum during 16 hours. Yield : 80.5g of4-[(l,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile (75.9 % yield).

Reference： [1]Patent: WO2006/125809,2006,A1 .Location in patent: Page/Page column 9; 10

2
[ 5637-42-3 ]
[ 22398-14-7 ]
4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		Examples Example 1A mixture of 64 g (0.4 mol) of <strong>[5637-42-3](4-cyanophenyl)guanidine</strong>, 98.4 g (1.2 mol) sodium acetate and 76.6g (0.44 mol) dimethyl(methoxymethylene)malonate in 600 ml N-methylpyrrolidinone (NMP) was heated to 100C and stirred for 1 hour at that temperature. 64.8 ml of demineralized water was added and the reaction mixture was further heated to reflux temperature. About 100 ml of the solvent was evaporated until the temperature of the reaction mixture reached the range of 155C to 160C. Subsequently the reaction mixture was refluxed during 30 hours. The whole is allowed to cool to 20-25C and 25g filtration aid was added. After stirring the mixture for 1 hour at 20-25C, the precipitate was filtered off and washed with 40 ml of NMP. The solvent was distilled off under vacuum and the residue was heated to 120C. 300 ml acetic acid was added dropwise (during 15 minutes) to the heated residue while keeping the temperature at 130C. After addition of the acetic acid, the mixture was heated to 150C and stirred at that temperature for 15 minutes. Subsequently, the mixture was allowed to cool to 20-25C. The formed precipitate was filtered off and washed with ethanol (I x 200 ml and 1 x 80ml). 400ml ethanol was added to the washed precipitate and this mixture was heated and refluxed for 1 hour. After cooling to 20-25C, the precipitate was filtered off, washed with 100 ml ethanol and dried at 50C under vacuum during 16 hours. Yield : 65.6g of 4-[(l,4-dihydro-4-oxo-2-pyrimidinyl)- amino]benzonitrile.

Reference： [1]Patent: WO2006/125809,2006,A1 .Location in patent: Page/Page column 9

3
[ 1093294-35-9 ]
[ 5637-42-3 ]
4-[(4-pyrazolo[1,5-b]pyridazin-3-yl-2-pyrimidinyl)amino]benzonitrile [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 5758 - 5762

4
[ 1212390-24-3 ]
[ 5637-42-3 ]
[ 1212390-27-6 ]

Reference： [1]European Journal of Medicinal Chemistry,2010,vol. 45,p. 244 - 255

5
[ 420-04-2 ]
[ 873-74-5 ]
[ 5637-42-3 ]

Yield	Reaction Conditions	Operation in experiment
		A solution of P-aminobenzonitrile (100 gm), ethanol (500 ml), concentrated nitric acid (36 ml) and aqueous cyanamide (50%, 54 ml) was heated at reflux. The solution was maintained for 16 hours at reflux. The reaction mass was further cooled to 0C and then added methyl tert-butyl ether (500 ml) at 0 to 5C. The reaction mass was maintained for 5 hours at 0 to 5C and separated solid obtained was collected by filtration to obtain 59 gm of guanidine nitrate.Guanidine nitrate (59 gm) was dissolved in water (590 ml) and then added sodium hydroxide solution (1M, 325 ml). The separated solid obtained was filtered and dried to obtain 33 gm of l-(4-cyanophenyl)guanidine.
33 g		A solution of P-aminobenzonitrile (100 gm), ethanol (500 ml), concentrated nitric acid (36 ml) and aqueous cyanamide (50%, 54 ml) was heated at reflux. The solution was maintained for 16 hours at reflux. The reaction mass was further cooled to 0 C. and then added methyl tert-butyl ether (500 ml) at 0 to 5 C. The reaction mass was maintained for 5 hours at 0 to 5 C. and separated solid obtained was collected by filtration to obtain 59 gm of guanidine nitrate. Guanidine nitrate (59 gm) was dissolved in water (590 ml) and then added sodium hydroxide solution (1M, 325 ml). The separated solid obtained was filtered and dried to obtain 33 gm of 1-(4-cyanophenyl)guanidine.
30 g	With nitric acid; In methanol; water; at 10 - 65℃; for 8h;	100 g of 4-aminobenzonitrile was dissolved in 500 mL of methanol and cooled the reaction mixture to 10-15 C. 161 mL of con. Nitric acid was added to the reaction mixture followed by 65.6 ml of 50% aqueous solution cynamide to the reaction mixture and maintained the reaction at 65 C. for 8 hrs. Cooled the reaction mass to 0 C. and charged 500 ml of methyl-t-butyl ether at 0 C. The solids were filtered, washed with water and acetone and dried to give 30 g of the product as a solid.

Reference： [1]European Journal of Medicinal Chemistry,2010,vol. 45,p. 244 - 255
[2]Patent: WO2012/1695,2012,A1 .Location in patent: Page/Page column 10
[3]Patent: US2013/96148,2013,A1 .Location in patent: Paragraph 0085; 0086
[4]Patent: US2015/336900,2015,A1 .Location in patent: Paragraph 0027; 0028

6
[ 5637-42-3 ]
[ 105-53-3 ]
[ 374067-80-8 ]

Yield	Reaction Conditions	Operation in experiment
	With ethanol; sodium; for 12h;Reflux;	Diethyl malonate (30 gm) was added to l-<strong>[5637-42-3](4-cyanophenyl)guanidine</strong> (30 gm) at room temperature. A solution of sodium (17.2 gm) in ethanol (450 ml) was added to the above reaction mass. The contents were heated to reflux and maintained for 12 hours. Distilled off the solvent completely under vacuum and then added water (500 ml). The reaction mass was stirred for 30 minutes and filtered. The solid obtained was dried to obtain 40 gm of 4-(4,6-dihydroxypyrimidine-2-yl-amino)benzonitrile.
40g	With ethanol; sodium; for 12h;Reflux;	Diethyl malonate (30 gm) was added to <strong>[5637-42-3]1-<strong>[5637-42-3](4-cyanophenyl)guanidine</strong></strong> (30 gm) at room temperature. A solution of sodium (17.2 gm) in ethanol (450 ml) was added to the above reaction mass. The contents were heated to reflux and maintained for 12 hours. Distilled off the solvent completely under vacuum and then added water (500 ml). The reaction mass was stirred for 30 minutes and filtered. The solid obtained was dried to obtain 40 gm of 4-(4,6-dihydroxypyrimidine-2-yl-amino)benzonitrile.
6.5 g	With methanol; sodium; In methanol; for 6h;Reflux; Inert atmosphere;	5.7 g of sodium metal was added to 200 mL of methanol at 0-5 C. with constant stirring under nitrogen atmosphere. 10 g of compound II dissolved in 200 mL of methanol was added to the solution followed by the dropwise addition of 10 g of diethyl malonate. The reaction mixture was heated to reflux for 6 h. After completion of the reaction, the solvent was removed under vacuum; water was added to the crude mixture and stirred for 30 minutes. The solid was filtered and adjusted the pH of the filtrate to 4.0-6.0. The separated solid was filtered, washed with acetone and dried to give 6.5 g of a solid.

Reference： [1]Patent: WO2012/1695,2012,A1 .Location in patent: Page/Page column 11
[2]Patent: US2013/96148,2013,A1 .Location in patent: Paragraph 0087
[3]Patent: US2015/336900,2015,A1 .Location in patent: Paragraph 0029; 0030

7
[ 5637-42-3 ]
[ 269055-15-4 ]

Reference： [1]Patent: WO2012/1695,2012,A1
[2]Patent: WO2012/147104,2012,A1
[3]Patent: US2013/96148,2013,A1
[4]Patent: US2013/116433,2013,A1
[5]Patent: US2015/336900,2015,A1

8
[ 5637-42-3 ]
[ 329187-59-9 ]

Reference： [1]Patent: WO2012/1695,2012,A1
[2]Patent: US2013/96148,2013,A1
[3]Patent: US2015/336900,2015,A1

9
[ 5637-42-3 ]
4-{6-amino-2-[(4-cyanophenyl)amino]pyrimidin-4-yloxy}-3,5-dimethylbenzenecarbonitrile [ No CAS ]

Reference： [1]Patent: WO2012/1695,2012,A1
[2]Patent: US2013/96148,2013,A1

10
[ 5637-42-3 ]
[ 1070377-34-2 ]

Reference： [1]Patent: WO2012/1695,2012,A1
[2]Patent: US2013/96148,2013,A1

11
[ 1355249-18-1 ]
[ 5637-42-3 ]
4-((5'-oxo-6',8'-dihydro-5'H-spiro[cyclopropane-1,7'-quinazolin]-2'-yl)amino)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	In ethanol; for 30h;Reflux;	Example 364-((5'-Oxo-6',8'-dihydro-5'H-spiro[cyclopropane-1,7'-quinazolin]-2'- yl)amino)benzonitrile[00178]Spiro[2.5]octane-5,7-dione (390 mg, 2.82 mmol) is dissolved in EtOAc (20 mL), and DMF-DMA (503 mg, 4.22 mmol) is added. The mixture is refluxed for 12 h, then evaporated to dryness to give an intermediate enamine. 165 mg (1 .1 mmol) of this intermediate together with 1 -<strong>[5637-42-3](4-cyanophenyl)guanidine</strong> (175 mg, 1 .1 mmol) are dissolved in abs. EtOH (8.5 ml_). The mixture is heated at reflux for 30 h, then cooled. The formed precipitate is filtered, washed with DEE and dried to provide the title compound (72 mg, 26%).1H NMR (CDCIs), deltaEta, 0.55 (s, 4H), 2.52 (s, 2H), 2.86 (s, 2H), 7.63 (d, 2H), 7.85 (d, 2H), 7.93 (s, 1 H), 9.04 (s, 1 H).LC/MS (M+H)+ = 291

Reference： [1]Patent: WO2012/85166,2012,A1 .Location in patent: Page/Page column 63-64

12
[ 5815-08-7 ]
[ 66116-81-2 ]
[ 5637-42-3 ]
[ 1383716-96-8 ]

Yield	Reaction Conditions	Operation in experiment
		Preparation of intermediate 4-(4-(2-(methylthio)-6-oxo-l,6-dihydropyrimidin-5- yl)pyrimidin-2-ylamino)benzonitrile (34) : (34)5-Acetyl-2-(methylthio)pyrimidin-4(3H)-one (33) (1.094 g, 5.94 mmol) was dissolved in l-tert-butoxy-N,N,N',N'-tetramethylmethanediamine (12.26 mL, 59.4 mmol), then the reaction mixture was heated at 120C for 6 hours. The reaction mixture was concentrated in vacuo, and dried over high vacuum for 1 hour. The crude intermediate was taken up in DMF (31.6 mL), then l-<strong>[5637-42-3](4-cyanophenyl)guanidine</strong> (2.076 g, 8.91 mmol) and K2C03 (4.10 g, 29.7 mmol) were added. The reaction mixture was heated at 120C for 48 hours. Additional 1 -<strong>[5637-42-3](4-cyanophenyl)guanidine</strong> (2.076 g, 8.91 mmol) and K2C03 (3.69 g, 26.7 mmol) were added, and the reaction mixture was stirred at 120C for additional 18 hours. The reaction mixture was cooled to rt, then was slowly poured into an ice-cooled IN HCl solution while stirring vigorously. The reaction mixture was neutralized with additional IN HCl, then the reaction mixture was allowed to stir for an additional 30 minutes. The resulting precipitate was filtered, washed multiple times with DI water, 2-propanol, then diethyl ether. The resulting crude product was dried over high vacuum for 18 hours to obtain the desired product as a red/brown solid (940 mg, 47% yield). MS (ES+): m/z = 337.2 (100) [MH+]. HPLC: tR = 1.35 minutes over 3 minutes. Purity: 72% [HPLC (LC/MS) at 220 nm].

Reference： [1]Patent: WO2012/85815,2012,A1 .Location in patent: Page/Page column 87-88

13
[ 5637-42-3 ]
[ 105-56-6 ]
[ 1398507-07-7 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium tert-butylate; In butan-1-ol; at 60 - 93℃; for 4h;	Example 1:Preparation of 4-(4-Amino-6-hydroxypyrimidin-2-ylamino)benzonitr-le (II):2000 ml of n-butanol and 192.8 g of potassium-tert-butoxide were added to the reaction vessel at 45 +/- 5 C and stirred for 30 mins. To the reaction mixture was added 194.42 g of ethylcyano acetate over 15 min and added 250 mL of n-butanol. The reaction mixture was heated to 60 +/- 5 C under stirring and was added 250 g of <strong>[5637-42-3]N-cyanophenyl guanidine</strong> followed by 250 mL of n-butanol and further heated to 93 +/- 3 C, maintained the same at4 hrs with stirring. After completion of the reaction, reaction mixture was cooled to 75 +/-5 C and was added 1750 mL of water and stirred at same temperature for 30 mins. Further, to the reaction mass was added 250 mL of glacial acetic acid; stirred and cooled to Room temperature (RT). The resulting solid was filtered and washed with 500 mL of water followed by washing with methanol and dried to yield titled compound.Dry weight: 290- 330 gm.
330 g	With potassium tert-butylate; In butan-1-ol; at 45 - 93℃; for 4h;	Example 1 Preparation of 4-(4-amino-6-hydroxypyrimidin-2-ylamino)benzonitrile (II) 2000 ml of n-butanol and 192.8 g of potassium-tert-butoxide were added to the reaction vessel at 45+-5 C. and stirred for 30 mins. To the reaction mixture was added 194.42 g of ethylcyano acetate over 15 min and added 250 ml of n-butanol. The reaction mixture was heated to 60+-5 C. under stirring and 250 g of <strong>[5637-42-3]N-cyanophenyl guanidine</strong> was added, followed by 250 ml of n-butanol and further heated to 93+-3 C., maintained the same at 4 hrs with stirring. After completion of the reaction, the reaction mixture was cooled to 75+-5 C. and 1750 ml of water was added and stirred at the same temperature for 30 mins. Further to the reaction mass was added 250 ml of glacial acetic acid; stirred and cooled to room temperature (RT). The resulting solid was filtered and washed with 500 ml of water, followed by washing with methanol and drying to yield the titled compound. Dry weight: 290-330 gm.

Reference： [1]Patent: WO2012/147104,2012,A1 .Location in patent: Page/Page column 9
[2]Patent: US2013/116433,2013,A1 .Location in patent: Paragraph 0053; 0054

14
[ 5637-42-3 ]
[ 1398507-08-8 ]

Reference： [1]Patent: WO2012/147104,2012,A1
[2]Patent: US2013/116433,2013,A1

15
[ 5637-42-3 ]
[ 1404118-66-6 ]

Reference： [1]Patent: WO2012/147104,2012,A1
[2]Patent: US2013/116433,2013,A1

16
[ 5637-42-3 ]
[ 1404118-67-7 ]

Reference： [1]Patent: WO2012/147104,2012,A1
[2]Patent: US2013/116433,2013,A1

17
[ 5637-42-3 ]
[ 1404118-68-8 ]

Reference： [1]Patent: WO2012/147104,2012,A1
[2]Patent: US2013/116433,2013,A1

18
[ 5637-42-3 ]
[ 269055-75-6 ]

Reference： [1]Patent: US2015/336900,2015,A1

19
[ 5637-42-3 ]
[ 1398507-09-9 ]

Reference： [1]Patent: US2015/336900,2015,A1

20
[ 87080-27-1 ]
[ 5637-42-3 ]
4-(6-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-4-(4-hydroxyphenyl)-2-imino-5,6-dihydropyridine-1(2H)-yl)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
49.44%	With triethylamine; In ethanol; at 75℃; for 6h;	To the reactor is added in the licorice chalcone A200mg (1mmol) and 1 - (4 - cyano phenyl) guanidine 123.07 mg (1.3mmol), adding 50 ml ethanol as solvent, adding 0.5 ml triethylamine as catalyst, placed over the magnetic stirrer stirring, heated to 75 C, reflux reaction for 6 hours. In the reaction process using thin layer chromatography tracking, monitoring the reaction in a timely manner the intensity, the raw materials after the reaction is complete cessation of heating, condensing device is removed. The mixture of the reaction system was concentrated under reduced pressure, filtration, column chromatography separation and purification, drying to obtain the target product 140.42 mg, yield is 49.44%.

Reference： [1]Patent: CN106674129,2017,A .Location in patent: Paragraph 0041; 0042; 0043

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P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 5637-42-3 ] {[proInfo.proName]}

Quality Control of [ 5637-42-3 ]

Related Doc. of [ 5637-42-3 ]

Product Details of [ 5637-42-3 ]

Safety of [ 5637-42-3 ]

Application In Synthesis of [ 5637-42-3 ]

[ 5637-42-3 ] Synthesis Path-Upstream 1~2

[ 5637-42-3 ] Synthesis Path-Downstream 1~20

Related Functional Groups of [ 5637-42-3 ]

Aryls

Amines

Nitriles

Related Parent Nucleus of [ 5637-42-3 ]

Guanidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 5637-42-3 ]

Related Parent Nucleus of
[ 5637-42-3 ]