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Chemical Structure| 578729-05-2 Chemical Structure| 578729-05-2

Structure of 578729-05-2

Chemical Structure| 578729-05-2

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Product Details of [ 578729-05-2 ]

CAS No. :578729-05-2
Formula : C19H30BNO4
M.W : 347.26
SMILES Code : O=C(OC(C)(C)C)N[C@@H](C1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1)C
MDL No. :MFCD18632958

Safety of [ 578729-05-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 578729-05-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 578729-05-2 ]
  • Downstream synthetic route of [ 578729-05-2 ]

[ 578729-05-2 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 578729-21-2 ]
  • [ 73183-34-3 ]
  • [ 578729-05-2 ]
YieldReaction ConditionsOperation in experiment
7.8 g With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 90℃; (R)-4-(1-((tert-Butoxycarbonyl)amino)ethyl)bromobenzene (4 g, 13.3 mmol) was placed in 25 mL of dioxane solution.Add KOAc (2.7 g, 26.7 mmol), bis(pinacolato)diboron (4 g, 15.34 mmol),PdCl 2 (dppf) (500 mg, 0.67 mmol) was reacted at 90 ° C overnight.The reaction solution was concentrated, dissolved in petroleum ether containing 20percent ethyl acetate, and the solution was brown, and the glass-glass funnel was filled with about 20 g of 300 mesh silica gel.The reaction solution was filtered through a silica gel column to remove dark impurities, and the filter cake was washed with the same ratio of solvent.To give a pale yellow solution, the solvent was removed under reduced pressure, to give 7.8 g orange oil,Yield >100percent.
References: [1] Patent: WO2005/63690, 2005, A1, . Location in patent: Page/Page column 28.
[2] Patent: US2003/220375, 2003, A1, .
[3] European Journal of Medicinal Chemistry, 2019, p. 407 - 422.
[4] Patent: CN109761902, 2019, A, . Location in patent: Paragraph 0094; 0099-0101.
  • 2
  • [ 24358-62-1 ]
  • [ 578729-05-2 ]
References: [1] European Journal of Medicinal Chemistry, 2019, p. 407 - 422.
[2] Patent: CN109761902, 2019, A, .
  • 3
  • [ 24424-99-5 ]
  • [ 578729-05-2 ]
References: [1] European Journal of Medicinal Chemistry, 2019, p. 407 - 422.
[2] Patent: CN109761902, 2019, A, .
 

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