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Chemical Structure| 59050-53-2 Chemical Structure| 59050-53-2

Structure of 59050-53-2

Chemical Structure| 59050-53-2

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Product Details of [ 59050-53-2 ]

CAS No. :59050-53-2
Formula : C14H10N2O2
M.W : 238.24
SMILES Code : O=[N+](C1=CC=CC=C1C(N2)=CC3=C2C=CC=C3)[O-]

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Application In Synthesis of [ 59050-53-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59050-53-2 ]

[ 59050-53-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 59050-53-2 ]
  • [ 32566-01-1 ]
YieldReaction ConditionsOperation in experiment
With tin; at 60℃; for 2h; General procedure: A mixture of 2-nitroacetophenone 5 (82 mg, 0.5 mmol), corresponding phenylhydrazine 1 (0.5 mmol), and polyphosphoric acid (1.0 g, the P2O5 content of 86%) was stirred at room temperature for 5 min. The process was strongly exothermic. The mixture was then stirred at 60 C until the complete disappearance of the starting reagents (~1.5 h, TLC control). Metallic Sn (1 mmol) was added, the mixture was stored for another 2 h, and the acylating agent (1.2 mmol) was added. The reaction mixture was then heated to 130 C (1,3,5-triazine was used as the synthetic equivalent of HCOOH at 100 C) and stored until the intermediate product disappeared completely (about 2 h). Next,The reaction mixture was cooled to room temperature, diluted with water (40 mL), and neutralized with 20% aqueous ammonia (~7 mL) until basic pH. The resulting mixture was extracted with ethyl acetate (4×15 mL), evaporated, and purifi ed by column chromatography using an acetone-hexane mixture (from 1 : 5to 1 : 1) as the eluent.
 

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