Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 63140-11-4 Chemical Structure| 63140-11-4

Structure of 63140-11-4

Chemical Structure| 63140-11-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 63140-11-4 ]

CAS No. :63140-11-4
Formula : C5H6ClNS
M.W : 147.63
SMILES Code : CC1SC(CCl)=CN=1
MDL No. :MFCD11111716
InChI Key :NHRPDSWALNDCIN-UHFFFAOYSA-N
Pubchem ID :12808794

Safety of [ 63140-11-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 63140-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63140-11-4 ]

[ 63140-11-4 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 56012-38-5 ]
  • [ 63140-11-4 ]
YieldReaction ConditionsOperation in experiment
90% With thionyl chloride; In dichloromethane; at 0 - 20℃; for 1h; To a stirred solution of <strong>[56012-38-5](2-methylthiazol-5-yl)methanol</strong> (2, 0.2 g, 1.55 mmol) in DCM (5 mL), was added SOCl2(0.23 mL, 3.10 mmol) drop wise at 0 C and the reaction mixture was stirred at rt for 1 h. The reaction mixture was neutralized using cold NaHC03(5 mL) solution and extracted with DCM (2 X 25 mL). Organic layer was washed with brine (5mL) solution, dried over anhydrous Na2S04 and evaporated to afford the product as yellow oil. (0.2 g, 90%, Yield). MS (ESI): Mass calcd. for C5H6C1NS , 146.99; m/z found 148.1 (M+H)+.
87% With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20℃; for 4h;Inert atmosphere; To a stirred solution of compound 64 (5 g, 38.75 mmol) in CH2C12 (150 mL) under inert atmosphere were added triethyl amine (8.3 mL, 58.13 mmol), methanesulfonyl chloride (4.6 mL, 46.51 mmol) at 0 C; warmed to RT and stirred for 4 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (50 mL) andextracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford compound 65 (5 g, 87%) as a pale-yellow syrup. TLC: 30% EtOAc/ hexanes (Rf: 0.8); LC-MS: 77.92%; 147.7 (M+1) (column; Ascentis Express C18, (50 x 3.0 mm, 2.7 jim); RT 1.71 mm. 0.025% Aq. TFA + 5% ACN: ACN + 5% 0.025% Aq. TFA, 1.2 mL/min).
82.32% With thionyl chloride; In dichloromethane; for 4h; (2-methylthiazol-5-yl) methanol (304 mg, 2.35 mmol) and thionyl chloride (0.9 mL,10mmol) was dissolved in dichloromethane (15mL), the reaction 4h. The reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (30 mL × 3)The residue was washed with saturated brine (15 mL) and dried over anhydrous sodium sulfate. The solvent was removed and the residue was subjected to column chromatography (eluent: PE /EtOAc (v / v) = 10/1) to give 286 mg of a light yellow oil, yield: 82.32%.
With thionyl chloride; In dichloromethane; at 0℃;Inert atmosphere; To a solution of <strong>[56012-38-5](2-methylthiazol-5-yl)methanol</strong> (1 eq) in DCM (10 mL) at 0C under N2 was added thionyl chloride (3 eq), dropwise. The reaction mixture was stirred at 0C for 2h. The reaction progress was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford 5-(chloromethyl)-2- methylthiazole as a brown liquid.

  • 3
  • [ 63140-11-4 ]
  • [ 63139-97-9 ]
  • 4
  • [ 40004-69-1 ]
  • [ 63140-11-4 ]
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 63140-11-4 ]

Chlorides

Chemical Structure| 135207-25-9

A539111 [135207-25-9]

5-(Chloromethyl)-2-methylthiazole hydrochloride

Similarity: 1.00

Chemical Structure| 921145-23-5

A521854 [921145-23-5]

2-(Chloromethyl)-5-methylthiazole

Similarity: 0.90

Chemical Structure| 1189464-33-2

A138656 [1189464-33-2]

2-(Chloromethyl)-5-methylthiazole hydrochloride

Similarity: 0.90

Chemical Structure| 131052-44-3

A137297 [131052-44-3]

5-(Chloromethyl)thiazole hydrochloride

Similarity: 0.82

Chemical Structure| 45438-77-5

A523590 [45438-77-5]

5-(Chloromethyl)thiazole

Similarity: 0.82

Related Parent Nucleus of
[ 63140-11-4 ]

Thiazoles

Chemical Structure| 135207-25-9

A539111 [135207-25-9]

5-(Chloromethyl)-2-methylthiazole hydrochloride

Similarity: 1.00

Chemical Structure| 921145-23-5

A521854 [921145-23-5]

2-(Chloromethyl)-5-methylthiazole

Similarity: 0.90

Chemical Structure| 1189464-33-2

A138656 [1189464-33-2]

2-(Chloromethyl)-5-methylthiazole hydrochloride

Similarity: 0.90

Chemical Structure| 4175-66-0

A225828 [4175-66-0]

2,5-Dimethylthiazole

Similarity: 0.84

Chemical Structure| 45438-77-5

A523590 [45438-77-5]

5-(Chloromethyl)thiazole

Similarity: 0.82