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[ CAS No. 640735-25-7 ] {[proInfo.proName]}

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Chemical Structure| 640735-25-7
Chemical Structure| 640735-25-7
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Product Details of [ 640735-25-7 ]

CAS No. :640735-25-7 MDL No. :MFCD11616419
Formula : C16H25FN2Si Boiling Point : -
Linear Structure Formula :- InChI Key :YESANHMKGXGZLQ-UHFFFAOYSA-N
M.W : 292.47 Pubchem ID :11266334
Synonyms :

Safety of [ 640735-25-7 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 640735-25-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 640735-25-7 ]
  • Downstream synthetic route of [ 640735-25-7 ]

[ 640735-25-7 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 640735-25-7 ]
  • [ 640735-23-5 ]
YieldReaction ConditionsOperation in experiment
94% With tetrabutyl ammonium fluoride In tetrahydrofuran at 0 - 20℃; for 1 h; Inert atmosphere [0722] To a stirred solution of 4-fluoro-i-(triisopropylsilyl)-1H-pyrrolo [2,3-bj pyridine (3 g, 10 mmol) in THF (15 mL) at 0 °C under an argon atmosphere was added tetra butyl ammonium fluoride 1M in THF (10.5 mL). The reaction mixture was warmed to room temperature and stirred for 1 h. After consumption of starting material (by TLC), the reactionmixture was diluted with water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 20percentEtOAc: Hexane to afford 4-fluoro-1H-pyrrolo [2,3-bj pyridine (1.3 g, 94percent) as an off-white solid. ‘H NMR (CDC13, 400 MHz): 10.52 (brs, 1H), 8.30-8.25 (m, 1H), 7.32-7.30 (m, 1H), 6.81 (dd, 1H), 6.59 (s, 1H); TLC: 20percent EtOAc Hexane (R 0.2).
Reference: [1] Organic Letters, 2003, vol. 5, # 26, p. 5023 - 5025
[2] Tetrahedron Letters, 2007, vol. 48, # 9, p. 1527 - 1529
[3] Patent: WO2017/31325, 2017, A1, . Location in patent: Paragraph 0722
  • 2
  • [ 640735-25-7 ]
  • [ 5654-97-7 ]
  • [ 956460-93-8 ]
Reference: [1] Patent: WO2007/125325, 2007, A1,
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