652-34-6|2,3,5,6-Tetrafluoro-4-hydroxybenzoic acid| Ambeed

CAS No. :	652-34-6
Formula :	C₇H₂F₄O₃
M.W :	210.08
SMILES Code :	O=C(O)C1=C(F)C(F)=C(O)C(F)=C1F
MDL No. :	MFCD00129952
InChI Key :	FTLHGQOBAPTEHE-UHFFFAOYSA-N
Pubchem ID :	98835

Safety of [ 652-34-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 652-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 652-34-6 ]

[ 652-34-6 ] Synthesis Path-Downstream 1~56

1
[ 124-38-9 ]
[ 769-39-1 ]
[ 652-34-6 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.
[2]Tetrahedron Letters,2010,vol. 51,p. 5930 - 5932.
[3]Journal of Organic Chemistry,1966,vol. 31,p. 746 - 749.

2
[ 2002-99-5 ]
[ 652-34-6 ]

References: [1]Journal of the Chemical Society,1962,p. 1801 - 1805.

3
[ 602-94-8 ]
[ 652-18-6 ]
[ 652-34-6 ]

References: [1]Journal of Physical Chemistry A,2000,vol. 104,p. 352 - 361.

5
[ 100-39-0 ]
[ 652-34-6 ]
[ 197903-54-1 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.
[2]Organic and Biomolecular Chemistry,2019,vol. 17,p. 1709 - 1713.

6
[ 64-17-5 ]
[ 652-34-6 ]
[ 123270-98-4 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

7
[ 115-20-8 ]
[ 652-34-6 ]
[ 562070-99-9 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

8
[ 652-34-6 ]
aminomethylated polystyrene [ No CAS ]
(polystyrene resin)-NH-C(O)-p-C₆F₆-OH [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2005,vol. 13,p. 2009 - 2014.

9
2-[(2-pyridin-2-ylquinoline-4-carbonyl)amino]ethylammonium chloride [ No CAS ]
[ 652-34-6 ]
2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(2,3,5,6-tetrafluoro-4-hydroxy-benzoylamino)-ethyl]-amide [ No CAS ]

References: [1]Tetrahedron,2004,vol. 60,p. 8729 - 8738.

10
[ 652-34-6 ]
[ 210228-13-0 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.
[2]Organic and Biomolecular Chemistry,2019,vol. 17,p. 1709 - 1713.

11
[ 652-34-6 ]
[ 562071-00-5 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

12
[ 652-34-6 ]
[ 562071-03-8 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

13
[ 652-34-6 ]
[ 562071-02-7 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

14
[ 652-34-6 ]
[ 562071-01-6 ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

15
[ 652-34-6 ]
C₂₇H₅F₁₃O₈ [ No CAS ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

16
[ 652-34-6 ]
C₄₁H₁₇F₁₃O₈ [ No CAS ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

17
[ 652-34-6 ]
C₄₁H₁₃F₁₃O₁₀ [ No CAS ]

References: [1]Macromolecules,2003,vol. 36,p. 4355 - 4359.

18
[ 652-34-6 ]
[ 197903-58-5 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

19
[ 652-34-6 ]
[ 197903-55-2 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

20
[ 652-34-6 ]
[ 197903-60-9 ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

21
[ 652-34-6 ]
Ethyl 2,3,5,6-tetrafluoro-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]benzoate [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

22
[ 652-34-6 ]
Benzyl 2,4,6-tris(benzyloxy)-3,5-difluorobenzoate [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

23
[ 652-34-6 ]
Sodium 2,3,5,6-tetrafluoro-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]benzoate [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 4265 - 4278.

24
[ 434-64-0 ]
[ 652-34-6 ]

References: [1]Journal of the Chemical Society,1962,p. 1801 - 1805.

25
[ 652-34-6 ]
C₈H₃F₅NOPol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		51.2 g of polystyrene-aminomethyl resin (loading 1.36 mmol/g, 69.6 mmol; from Argonaut Technologies, USA) are suspended in 700 ml of DMF. 41.6 g (107.8 mmol) of HOBt and 24.1 g (114.8 mmol) of 4-hydroxy-2,3,5,6-tetrafluoro-benzoic acid are added. After 15 min, 16.9 ml (107.8 mmol) of N,N'-diisopropylcarbodiimide are added to the reaction mixture while stirring gently, and it is then stirred overnight. It is filtered, and the remaining resin is washed with DMF. The resulting resin is resuspended in 450 ml of DMF, mixed with 8.26 ml (83.5 mmol) of piperidine and shaken. After 2 h, filtration is repeated and the remaining resin is added to a solution of 120 ml of 1 M hydrochloric acid in 500 ml of DMF and shaken for a further 2 h. Renewed filtration is followed by washing with 500 ml each of DMF, THF and DCM. Drying in vacuo at 50 C. results in 77.2 g of the polymer-bound title compound.

References: [1]Patent: US2007/37844,2007,A1 .Location in patent: Page/Page column 8.

26
[ 19161-30-9 ]
[ 652-34-6 ]

References: [1]Journal of the Chemical Society C: Organic,.
Journal of the Chemical Society [Section] C: Organic,1968,p. 1569 - 1575.
[2]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.

27
[ 553-26-4 ]
[ 5970-45-6 ]
[ 652-34-6 ]
[Zn₂(4,4'-bipyridine)(2,3,5,6-tetrafluoro-4-hydroxybenzoate)2]*(4,4'-bipyridine) [ No CAS ]

References: [1]Inorganic Chemistry,2010,vol. 49,p. 4594 - 4598.

28
[ 553-26-4 ]
cobalt(II) chloride hexahydrate [ No CAS ]
[ 652-34-6 ]
[Co₂(4,4'-bipyridine)(2,3,5,6-tetrafluoro-4-hydroxybenzoate)2]*(4,4'-bipyridine) [ No CAS ]

References: [1]Inorganic Chemistry,2010,vol. 49,p. 4594 - 4598.

29
[ 475289-85-1 ]
[ 652-34-6 ]
[ 1257325-77-1 ]

References: [1]Tetrahedron Letters,2010,vol. 51,p. 5930 - 5932.

30
[ 67-56-1 ]
[ 652-34-6 ]
[ 58286-07-0 ]

Yield	Reaction Conditions	Operation in experiment
90%	With sulfuric acid; for 16h;Reflux;	To a solution of <strong>[652-34-6]2,3,5,6-tetrafluoro-4-hydroxybenzoic acid</strong> hydrate (5.2 g, 22.8 mmol) in methanol (400 ml) concentrated sulphuric acid (98%, 2 ml)was added. The solutionwas heated to reflux for 16 h. TLC was used to monitor the reaction. After the complete conversion, methanol was removed, and then water (100 ml) was added to the residual. Dichloromethane was used to extract the product from aqueous solution. The extract was dried over anhydrous magnesium sulphate, and the solvent was removed under reduced pressure to give white solid methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (5.01 g, yield 90%). 1H NMR, CD3OD: 4.92(br s,1H, OH), 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO),148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F) To a solution of methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (1.02 g, 4.55 mmol) in anhydrous THF (10 ml) was added a solution of thallium ethoxide (1.19 g, 4.78 mmol, 1.05 eq) in anhydrous THF (5 ml). The white solid was formed and the suspension was stirred for further 3 h. The white solid was collected, washed with anhydrous THF, dried under reduced pressure, to give product Tl-6 (1.82 g, yield 90%). 1H NMR, CD3OD: 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO), 148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F).

References: [1]Journal of Organometallic Chemistry,2011,vol. 696,p. 1591 - 1599.

31
[ 827-15-6 ]
[ 652-34-6 ]

32
[ 344-07-0 ]
[ 652-34-6 ]

33
[ 773-82-0 ]
[ 652-34-6 ]

34
[ 344-04-7 ]
[ 652-34-6 ]

35
[ 20925-85-3 ]
[ 652-34-6 ]

References: [1]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[2]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[3]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[4]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[5]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.
[6]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.

36
[ 27318-28-1 ]
[ 652-34-6 ]

References: [1]Gmelin Handbuch der Anorganischen Chemie,Gmelin Handbook: F: PerFHalOrg.9, 7, page 50 - 101.

37
[ 653-37-2 ]
[ 652-34-6 ]

38
N-mono-trityl 1,6-diaminohexane acetic acid salt [ No CAS ]
[ 652-34-6 ]
2,3,5,6-tetrafluoro-4-hydroxy-N-(6-(tritylamino)hexyl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
58%		Mono-trityl 1,6-diaminohexane acetic acid salt (9a) (117.2 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (15% -> 30% ethyl acetate in hexane) to yield 90 mg (0.16 mmol, 58% isolated yield).
58%		Mono-trityl 1,6-diaminohexane acetic acid salt (9a) (117.2 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (15% -> 30% ethyl acetate in hexane) to yield 90 mg (0.16 mmol, 58% isolated yield).

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 14726 - 14730.
[2]Patent: WO2014/145257,2014,A2 .Location in patent: Paragraph 0146.
[3]Patent: WO2018/119476,2018,A1 .Location in patent: Paragraph 0134; 0137.

39
N-mono-trityl 1,6-diaminohexane acetic acid salt [ No CAS ]
[ 652-34-6 ]
C₄₂H₅₃F₄N₅O₈*C₂HF₃O₂ [ No CAS ]

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 14726 - 14730.
[2]Patent: WO2018/119476,2018,A1 .

40
N-mono-trityl ethylenediamine acetic acid salt [ No CAS ]
[ 652-34-6 ]
2,3,5,6-tetrafluoro-4-hydroxy-N-(2-(tritylamino)ethyl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%		Mono-trityl ethylenediamine acetic acid salt (9b) (100 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (20% -> 35% ethyl acetate in hexane) to yield 90 mg (0.18 mmol, 65% isolated yield). 1H NMR (400 MHz, DMSO) δ = 8.77 (t, J=6.0, 1H), 7.39 (d, J=7.8, 6H), 7.27 (t, J=7.7, 6H), 7.17 (t, J=7.2, 3H), 3.40 - 3.35 (m, 2H), 2.86 - 2.77 (m, 1H), 2.14 - 2.04 (m, 2H).
65%		Mono-trityl ethylenediamme acetic acid salt (9b) (100 mg, 0.28 mmol) was taken up in DCM and washed with sat. aq. NaHC03, dried over Na2S04 and (0224) concentrated in vacuo. The amine was dissolved in DMF and HOBt monohydrate (43 mg, 0.28 mmol, 1 equiv.), EDC (54 mg, 0.28 mmol, 1 equiv.) and 2,3,5,6- tetrafluoro-4-hydroxybenzoic acid (12) (59 mg, 0.28 mmol, 1 equiv.) were added and the reaction mixture was stirred overnight, before being concentrated in vacuo. The crude was purified by flash column chromatography (20% -> 35% ethyl acetate in hexane) to yield 90 mg (0.18 mmol, 65% isolated yield). lH NMR (400 MHz, DMSO) δ = 8.77 (t, 7=6.0, 1H), 7.39 (d, 7=7.8, 6H), 7.27 (t, 7=7.7, 6H), 7.17 (t, 7=7.2, 3H), 3.40 - 3.35 (m, 2H), 2.86 - 2.77 (m, 1H), 2.14 - 2.04 (m, 2H).

References: [1]Journal of the American Chemical Society,2013,vol. 135,p. 14726 - 14730.
[2]Patent: WO2014/145257,2014,A2 .Location in patent: Paragraph 0147.
[3]Patent: WO2018/119476,2018,A1 .Location in patent: Paragraph 0134; 0138.

41
[ 652-34-6 ]
dibenzyl [2,3,5,6-tetrafluoro-4-(hydroxymethyl)phenyl] phosphate [ No CAS ]

References: [1]ChemBioChem,2014,vol. 15,p. 961 - 976.

42
[ 652-34-6 ]
[ 61596-38-1 ]

References: [1]ChemBioChem,2014,vol. 15,p. 961 - 976.

43
[ 652-34-6 ]
4-[bis(benzyloxy)phosphoryl]oxy}-2,3,5,6-tetrafluorobenzyl (4-methyl-2-oxo-2H-chromen-7-yl)carbamate [ No CAS ]

References: [1]ChemBioChem,2014,vol. 15,p. 961 - 976.

44
N-mono-trityl 1,6-diaminohexane acetic acid salt [ No CAS ]
[ 652-34-6 ]
C₄₃H₅₃F₄N₅O₉*C₂HF₃O₂ [ No CAS ]

References: [1]Patent: WO2014/145257,2014,A2 .

45
[ 602-94-8 ]
difluoromaleic acid [ No CAS ]
[ 392-47-2 ]
[ 652-34-6 ]

References: [1]Journal of the American Chemical Society,2014,vol. 136,p. 11321 - 11330.

46
[ 100-39-0 ]
[ 652-34-6 ]
[ 210228-13-0 ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 24h;Cooling with ice;	Cesium carbonate excess of the catalyst base (56.14g, 172.3mmol) and methyl 2, 3-difluoro-4-hydroxybenzoic acid (15g, 86.2mmol) for N, paste has better mouth feeling and agitating N-dimethylformamide was dissolved. Then the first bath freezing (ice bath) using benzyl bromide (10.3 ml, 86.2mmol) a blended 24 houses an mix solution which is then reacted time at room temperature. Excess distilled water of agent is placed a request of the reaction, until is pH2 to the precipitation the dripped into HCl. To filter out precipitate a solid product in the form of a powder (yield: 74.6%)of title compound are obtained.

References: [1]Patent: KR2015/105610,2015,A .Location in patent: Paragraph 0099; 0142-0144.

47
[ 71-36-3 ]
[ 652-34-6 ]
butyl 2,3,5,6-tetra-fluoro-4-hydroxybenzoate [ No CAS ]

References: [1]ACS Medicinal Chemistry Letters,2018,vol. 9,p. 51 - 55.

48
[ 652-34-6 ]
C₂₃H₁₈F₄O [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2019,vol. 17,p. 1709 - 1713.

49
(2-aminoethyl)trimethylammonium trifluoroacetate [ No CAS ]
[ 652-34-6 ]
C₁₂H₁₅F₄N₂O₂⁽¹⁺⁾*C₂F₃O₂^(1-) [ No CAS ]

References: [1]Chemical Communications,2019,vol. 55,p. 12507 - 12510.

50
[ 652-34-6 ]
C₂₄H₂₈F₄N₂O₄Si₂⁽¹⁺⁾ [ No CAS ]

References: [1]Chemical Communications,2019,vol. 55,p. 12507 - 12510.

51
[ 652-34-6 ]
C₃₆H₄₉F₄N₉O₈⁽²⁺⁾*2C₂F₃O₂^(1-) [ No CAS ]

References: [1]Chemical Communications,2019,vol. 55,p. 12507 - 12510.

52
[ 652-34-6 ]
C₂₃H₂₃F₄N₆O₆⁽¹⁺⁾*C₂F₃O₂^(1-) [ No CAS ]

References: [1]Chemical Communications,2019,vol. 55,p. 12507 - 12510.

53
[ 14648-57-8 ]
[ 652-34-6 ]
C₁₉H₂₀F₄O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		2.31 parts of the salt represented by formula (I-1-a) and 20 parts of acetonitrile are mixed,The mixture was stirred at 23 C for 30 minutes.1.80 parts of carbonyldiimidazole was added to the obtained mixed solution,The mixture was stirred at 60 C for 2 hours.2.17 parts of the compound represented by the formula (I-27-b) was added to the obtained reaction solution, and the mixture was stirred at 60 C. for 2 hours and then cooled to 23 C. Chloroform (40 parts) and ion-exchanged water (20 parts) were added to the obtained reaction mixture, and the mixture was stirred at 23 C. for 30 minutes, then, separated, and the organic layer was taken out. 20 parts of ion-exchanged water was added to the obtained organic layer, the mixture was stirred at 23 C. for 30 minutes, and then liquid-separated to take out the organic layer. This water washing operation was repeated 5 times. The obtained organic layer was concentrated, and the concentrated mixture was applied to a column (silica gel 60N (spherical, neutral) 100-210 μm; manufactured by Kanto Chemical Co., Inc., developing solvent: n-heptane / ethyl acetate = 1/1). By fractionating, 2.18 parts of a compound represented by the formula (I-27-c) was obtained.

References: [1]Patent: JP2020/59708,2020,A .Location in patent: Paragraph 0226.

54
[ 625122-36-3 ]
[ 652-34-6 ]
C₂₀H₂₀F₄O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		2.31 parts of the compound represented by the formula (I-1-a), 10 parts of dimethylformamide and carbonic acidAfter mixing 0.80 parts of potassium and stirring at 23 C for 30 minutes, the mixture was further stirred at 80 C for 1 hour.I stirred. The obtained mixed solution was added with 2.93 parts of a compound represented by the formula (I-211-b) and a yolk.Add 0.05 parts of potassium iodide,After stirring at 80 C for 6 hours, the mixture was cooled to 23 C.20 parts of chloroform and 10 parts of ion-exchanged water were added to the obtained reaction mixture, and the mixture was heated at 23 C. for 30 minutes.After stirring for a while, the layers were separated and the organic layer was taken out. To the obtained organic layer, 10 parts of ion-exchanged water was added, and the mixture was stirred at 23 C. for 30 minutes, then liquid-separated, and the organic layer was taken out. This water washing operation was repeated 3 times. The obtained organic layer was concentrated, and the concentrated mixture was subjected to a column (silica gel 60N (spherical, neutral) 100-210 μm; manufactured by Kanto Chemical Co., Inc., developing solvent: n-heptane / ethyl acetate = 1/1). By collecting3.92 parts of the compound represented by the formula (I-211-c) was obtained.

References: [1]Patent: JP2020/59708,2020,A .Location in patent: Paragraph 0228.

55
[ 652-34-6 ]
C₂₃H₂₁F₆O₉S^(1-)*C₁₈H₁₂F₃S⁽¹⁺⁾ [ No CAS ]

References: [1]Patent: JP2020/59708,2020,A .

56
[ 652-34-6 ]
C₂₂H₁₉F₆O₉S^(1-)*C₁₈H₁₅S⁽¹⁺⁾ [ No CAS ]

References: [1]Patent: JP2020/59708,2020,A .

Historical Records

Technical Information

• Acidity of Phenols • Alkyl Halide Occurrence • Arndt-Eistert Homologation • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Electrophilic Substitution of the Phenol Aromatic Ring • Etherification Reaction of Phenolic Hydroxyl Group • Fischer Indole Synthesis • Grignard Reaction • Halogenation of Phenols • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Oxidation of Phenols • Passerini Reaction • Paternò-Büchi Reaction • Pechmann Coumarin Synthesis • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reformatsky Reaction • Reimer-Tiemann Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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[ 652-34-6 ]

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 652-34-6

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CAS No.: 652-34-6

Alternative Products

Product Details of [ 652-34-6 ]

Safety of [ 652-34-6 ]

Application In Synthesis of [ 652-34-6 ]

[ 652-34-6 ] Synthesis Path-Downstream 1~56

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Related Functional Groups of
[ 652-34-6 ]

Fluorinated Building Blocks

Aryls

Carboxylic Acids

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

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{[proInfo.proName]}

CAS No.: 652-34-6

{[proInfo.proName]}

CAS No.: 652-34-6

Alternative Products

Product Details of [ 652-34-6 ]

Safety of [ 652-34-6 ]

Application In Synthesis of [ 652-34-6 ]

[ 652-34-6 ] Synthesis Path-Downstream 1~56

Related Products

Historical Records

Technical Information

Categories

Related Functional Groups of [ 652-34-6 ]

Fluorinated Building Blocks

Aryls

Carboxylic Acids

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Related Functional Groups of
[ 652-34-6 ]