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Chemical Structure| 65214-59-7 Chemical Structure| 65214-59-7

Structure of 65214-59-7

Chemical Structure| 65214-59-7

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Product Details of [ 65214-59-7 ]

CAS No. :65214-59-7
Formula : C13H7Cl2FO
M.W : 269.10
SMILES Code : O=C(C1=CC=C(Cl)C=C1Cl)C2=CC=C(F)C=C2
MDL No. :MFCD00135179

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Application In Synthesis of [ 65214-59-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65214-59-7 ]

[ 65214-59-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65214-59-7 ]
  • [ 20075-26-7 ]
  • [ 49823-01-0 ]
YieldReaction ConditionsOperation in experiment
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; diethyl ether; hexane; water; A. Preparation of alpha-(2,4-dichlorophenyl)-alpha-(p-fluorophenyl)-<strong>[20075-26-7]1-(methoxymethyl)imidazole</strong>-2-methanol At -60 C. and under a nitrogen atmosphere, 44 ml. (0.072 mol) of n-butyl lithium (15% solution in n-hexane) was added dropwise under stirring to a solution of 7.8 g (0.07 mol) of <strong>[20075-26-7]1-(methoxymethyl)imidazole</strong> and 8.1 g (0.072 mol) of N,N,N',N'-tetramethylethylenediamine in 100 ml of anhydrous tetrahydrofuran. The mixture was stirred for one hour and then 18.9 g (0.070 mol) of 2,4-dichloro-4'-fluorobenzophenone in 100 ml of anhydrous tetrahydrofuran were added at -60 C. The solution was stirred for one hour at -60 C. and kept standing overnight at room temperature. Then 50 ml of water were added and the solid matter formed was filtered off. The filtrate was extracted with tetrahydrofuran and diethyl ether. The organic phase was dried over sodium sulphate and the solvents were distilled off. Diethyl ether was added to the semisolid residue and the solid matter was filtered off. This product was combined with the solid matter obtained after the addition of water. The substance was twice crystallized from acetone with a small amount of dimethylformamide. alpha-(2,4-Dichlorophenyl)-alpha-(p-fluorophenyl)-<strong>[20075-26-7]1-(methoxymethyl)imidazole</strong>-2-methanol was obtained. Melting point 179 C.
 

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