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Chemical Structure| 67515-56-4 Chemical Structure| 67515-56-4

Structure of 67515-56-4

Chemical Structure| 67515-56-4

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Product Details of [ 67515-56-4 ]

CAS No. :67515-56-4
Formula : C8H3ClF4O
M.W : 226.56
SMILES Code : O=C(Cl)C1=CC=C(F)C(C(F)(F)F)=C1
MDL No. :MFCD00061159
Boiling Point : No data available
InChI Key :BUDISZQHCHGLJW-UHFFFAOYSA-N
Pubchem ID :144253

Safety of [ 67515-56-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 67515-56-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 67515-56-4 ]

[ 67515-56-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 67515-55-3 ]
  • [ 67515-56-4 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In N,N-dimethyl-formamide; toluene; a 4-Fluoro-3-trifluoromethylbenzoyl Chloride 1.5 g of <strong>[67515-55-3]4-fluoro-3-trifluoromethylbenzoic acid</strong>, 0.65 ml of thionyl chloride and two drops of DMF are heated under reflux for 12 h in 17 ml of toluene and the mixture is subsequently concentrated and used without further purification.
With thionyl chloride; for 4h;Reflux; <strong>[67515-55-3]4-fluoro-3-trifluoromethylbenzoic acid</strong> (0.32g, 1.56mmol) and was heated for 4 hours the mixture at reflux thionyl chloride (5ml). The reaction mixture was cooled to room temperature, the excess reagent was removed under reduced pressure to give the crude acid chloride. The crude acid chloride and 2- (4-aminophenyl) -6-methoxy benzothiazole (0.40 g, 1.56 mmol) and using in dry pyridine (12 ml), as described in the section amide coupling the amide prepared, after recrystallization from AcOH, to give the title compound (0.502g, 72%) as a colorless solid.
With oxalyl dichloride; In dichloromethane; at 20℃; for 2.5h;Cooling with ice; Synthesis of 2-(4-fluoro-3-trifluoromethylphenyl)benzothiazole:4-Fluoro-3-trifluoromethylbenzoic acid (20 mmol) was dissolved in 50 mL of dry DCM.A catalytic amount of DMF was added, and oxalyl chloride (3.4 mL, 40 mmol) was added dropwise in an ice water bath.After stirring for 30 min, it was stirred at room temperature for 2 h. Spin the reaction solution,40 mL of dry toluene was added to prepare an acid chloride solution, which was sealed for use.o-Aminothiophenol (2.5 g, 20 mmol) was dissolved in 20 mL of dry toluene.The prepared acid chloride solution is added dropwise with stirring.The reaction was carried out at 110 C for 3 h under N2 protection. Cool to room temperature,The reaction mixture was diluted with ethyl acetate (100 ml) and saturated sodium hydrogen sulfate (50 mL).The organic phase was separated, and the aqueous phase was washed with ethyl acetate (2×50 ml).Dry over anhydrous sodium sulfate, filter, and concentrate on silica gel column chromatography.2-(4-Fluoro-3-trifluoromethylphenyl)benzothiazole (light yellow solid) was obtained.
  • 2
  • [ 67515-56-4 ]
  • [ 4506-66-5 ]
  • [ 1245629-73-5 ]
 

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Robinson Annulation • Rosenmund Reduction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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