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Chemistry
Heterocyclic Building Blocks
Quinolines
5-Chloroquinolin-2-amine
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Quinolines
Amines Chlorides

[ CAS No. 68050-37-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 68050-37-3
Chemical Structure| 68050-37-3
Structure of 68050-37-3 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 68050-37-3 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 68050-37-3 ]

CAS No. :68050-37-3 MDL No. :MFCD16659152
Formula : C9H7ClN2 Boiling Point : -
Linear Structure Formula :- InChI Key :LFNYFPRSHXRDDH-UHFFFAOYSA-N
M.W : 178.62 Pubchem ID :14067426
Synonyms :

Calculated chemistry of [ 68050-37-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 51.16
TPSA : 38.91 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.64 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.77
Log Po/w (XLOGP3) : 2.47
Log Po/w (WLOGP) : 2.48
Log Po/w (MLOGP) : 2.16
Log Po/w (SILICOS-IT) : 2.36
Consensus Log Po/w : 2.25

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.12
Solubility : 0.135 mg/ml ; 0.000758 mol/l
Class : Soluble
Log S (Ali) : -2.93
Solubility : 0.209 mg/ml ; 0.00117 mol/l
Class : Soluble
Log S (SILICOS-IT) : -3.96
Solubility : 0.0198 mg/ml ; 0.000111 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.65

Safety of [ 68050-37-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 68050-37-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 68050-37-3 ]

[ 68050-37-3 ] Synthesis Path-Downstream   1~21

  • 1
  • [ 70-23-5 ]
  • [ 68050-37-3 ]
  • [ 113508-51-3 ]
YieldReaction ConditionsOperation in experiment
With methyloxirane; In 1,2-dimethoxyethane; ethanol; EXAMPLE 29 ethyl 6-chloroimidazo-[1,2-a]-quinoline-2-carboxylate 140 mg of <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> were dissolved in 2.5 ml of dimethoxyethane and then a mixture of 170 mg of ethyl bromopyruvate and 30 mg of propylene oxide was added. The mixture was stirred at room temperature for 2 hours and 2 ml of ether were added. Then, the mixture was cooled in ice and the precipitated quaternary salt was filtered off, was dissolved in 5 ml of ethanol and the solution was heated at reflux for 2 hours. Then, the solvent was removed under vacuum and the residue was partitioned between sodium bicarbonate solution and chloroform. The chloroform solution was dried over magnesium sulfate and was evaporated to dryness. The residue was chromatographed over silica with chloroform as eluent and the purified product was recrystallized from ethyl acetate/petroleum ether to obtain colorless needles of ethyl 6-chloroimidazo-[1,2-a]-quinoline-2-carboxylate melting at 193-194 C. I.R. (KBr Disc): 3145 cm-1 (C--H1 stretch) 1707 cm-1 (Ester C=O) Analysis: C14 H11 N2 Cl O2. Calculated: %C 61.21; %H 4.04; %N 10.20; Found: C 61.13; H 4.05; N 10.07
Reference： [1]Journal of Medicinal Chemistry,1988,vol. 31,p. 1098 - 1115
[2]Patent: US4279912,1981,A
  • 2
  • [ 769-11-9 ]
  • [ 107-13-1 ]
  • [ 68050-37-3 ]
Reference： [1]Journal of Medicinal Chemistry,1988,vol. 31,p. 1098 - 1115
  • 3
  • [ 59412-12-3 ]
  • [ 68050-37-3 ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 4
  • [ 130277-32-6 ]
  • [ 68050-37-3 ]
  • (2'R)-cis-5-[2',5'-dihydro-4'-(tert-butyldiphenylsilyl)oxy-2'-furanyl]-2-aminoquinoline [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 5
  • [ 23981-22-8 ]
  • [ 68050-37-3 ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 6
  • [ 68050-37-3 ]
  • 5-(β-D-glyceropentofuran-3'-ulos-1'-yl)-2-aminoquinoline [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 7
  • [ 68050-37-3 ]
  • 5-(2'-deoxy-β-D-threo-pentofuranosyl)-2-aminoquinoline [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 8
  • [ 68050-37-3 ]
  • N2-isobutyryl-5-(2'-deoxy-β-D-threo-pentofuranosyl)-2-aminoquinoline [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 9
  • [ 68050-37-3 ]
  • 5-((2R,4R,5R)-4-Trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-quinolin-2-ylamine [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 10
  • [ 68050-37-3 ]
  • N-[5-((2R,4R,5R)-4-Trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-quinolin-2-yl]-isobutyramide [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 11
  • [ 68050-37-3 ]
  • N2-isobutyryl-5-[2'-deoxy-β-D-threo-pentofuranosyl-5'-O-(4,4'-dimethoxytrityl)]-2-aminoquinoline [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 12
  • [ 68050-37-3 ]
  • N2-isobutyryl-5-[2'-deoxy-β-D-threo-pentofuranosyl-3'-O-(2-cyanoethoxy-)(diisopropylamino)phosphino-5'-O-(4,4'-dimethoxytrityl)]-2-aminoquinoline [ No CAS ]
Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 12657 - 12665
  • 13
  • [ 68050-37-3 ]
  • [ 113508-40-0 ]
Reference： [1]Journal of Medicinal Chemistry,1988,vol. 31,p. 1098 - 1115
  • 14
  • [ 46249-41-6 ]
  • [ 68050-37-3 ]
  • N-(5-Chloroquinoline-2-yl)-4-sulfamoylbenzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 26 N-(5-Chloroquinolin-2-yl)-4-sulfamoylbenzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Preparation Example 2) and 4-sulfamoylbenzenesulfonyl chloride by the procedure of Example 1. 1H-NMR (CDCl3) delta (ppm): 7.42-7.49 (3H, m), 7.58 (1H, t, J=8.0 Hz), 8.00-8.12 (4H, m,), 8.39 (1H, d, J=9.3 Hz).
Synthetic Example 26b N-(5-Chloroquinoline-2-yl)-4-sulfamoylbenzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 4-sulfamoylbenzenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 7.42-7.49(3H, m,), 7.58(1H, t,J=8.0Hz), 8.00-8.12(4H,m,) 8.39(1H, d, J=9.3Hz).
SYNTHETIC EXAMPLE 26b N-(5-Chloroquinoline-2-yl)-4-sulfamoylbenzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 4-sulfamoylbenzenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 7.42-7.49 (3H, m,), 7.58(1H, t, J=8.0 Hz), 8.00-8.12(4H, m,) 8.39(1H, d, J=9.3 Hz).
Reference： [1]Patent: US2003/144507,2003,A1
[2]Patent: EP1258252,2002,A1
[3]Patent: US2004/18192,2004,A1
  • 15
  • [ 347146-77-4 ]
  • [ 68050-37-3 ]
  • N-(5-Chloroquinolin-2-yl)-4-(N-ethylsulfamoyl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 27 N-(5-Chloroquinolin-2-yl)-4-(N-ethylsulfamoyl)benzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Preparation Example 2) and 4-(N-ethylsulfamoyl)benzenesulfonyl chloride by the procedure of Example 1. 1H-NMR (CDCl3) delta (ppm): 1.14 (3H, t, J=7.5 Hz), 3.01-3.09 (2H, m), 7.08 (1H, d, J=9.5 Hz), 7.42 (1H, dd, J=7.6 Hz, 1.3 Hz), 7.49 (1H, t, J=7.6 Hz),7.65 (1H, dd, J=7.6 Hz, 1.3 Hz), 7.96 (2H, d, J=8.7 Hz), 8.10 (2H, d, J=8.7 Hz), 8.31 (1H, d, J=9.5 Hz).
Reference： [1]Patent: US2003/144507,2003,A1
  • 16
  • [ 98-59-9 ]
  • [ 68050-37-3 ]
  • N-(5-Chloroquinoline-2-yl)-4-methylbenzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 25 N-(5-Chloroquinolin-2-yl)-4-methylbenzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Preparation Example 2) and 4-toluenesulfonyl chloride by the procedure of Example 1. 1H-NMR (CDCl3) delta (ppm): 2.41 (3H, s), 6.98 (1H, d, J=9.3 Hz), 7.28 (2H, d, J=8.2 Hz), 7.35 (1H, d, J=7.9 Hz), 7.41 (1H, d, J=7.9 Hz), 7.53 (1H, t, J=7.9 Hz), 7.88 (2H, d, J=8.2 Hz), 8.26 (1H, d, J=9.3 Hz)
Synthetic Example 25b N-(5-Chloroquinoline-2-yl)-4-methylbenzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 4-toluenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 2.41(3H, s), 6.98(1H, d, J=9.3Hz), 7.28(2H, d, J=8.2Hz), 7.35(1H, d, J=7.9Hz), 7.41(1H, d, J=7.9Hz), 7.53(1H, t, J=7.9Hz), 7.88(2H, d, J=8.2Hz), 8.26(1H, d, J=9.3Hz).
SYNTHETIC EXAMPLE 25b N-(5-Chloroquinoline-2-yl) -4-methylbenzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 4-toluenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 2.41(3H, s), 6.98(1H, d, J=9.3 Hz), 7.28(2H, d, J=8.2 Hz), 7.35(1H, d, J=7.9 Hz), 7.41(1H, d, J=7.9 Hz), 7.53(1H, t, J=7.9 Hz), 7.88(2H, d, J=8.2 Hz), 8.26(1H, d, J=9.3 Hz).
Reference： [1]Patent: US2003/144507,2003,A1
[2]Patent: EP1258252,2002,A1
[3]Patent: US2004/18192,2004,A1
  • 17
  • [ 98-60-2 ]
  • [ 68050-37-3 ]
  • 4-Chloro-N-(5-chloroquinoline-2-yl)-benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; In water; Example 20 4-Chloro-N-(5-chloroquinolin-2-yl)-benzenesulfonamide Pyridine (1 ml) and 4-chlorobenzenesulfonyl chloride (255 mg) were added to <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (119 mg, Preparation Example 2) at room temperature. After stirring at room temperature for 3 days, water was added thereto and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate and concentrated. Then, the resulting solid was washed with methanol, to give the title compound (20 mg). 1H-NMR (CDCl3) delta (ppm): 6.96 (1H, d, J=9.7 Hz), 7.34 (1H, d, J=8.4 Hz), 7.42-7.48 (3H, m), 7.54 (1H, t, J=8.4 Hz), 7.94 (2H, d, J=6.3 Hz), 8.29 (1H, d, J=9.7 Hz).
With pyridine; In water; Synthetic Example 20b 4-Chloro-N-(5-chloroquinoline-2-yl)-benzenesulfonamide Pyridine (1 ml) and 4-chlorobenzenesulfonyl chloride (255 mg) were added to <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (119 mg, Production Example 2b) at room temperature, followed by stirring at room temperature for 3 days. Then, water was added thereto, followed by extracting with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate and concentrated. Then, theresulting solid was washed with methanol, to give the title compound (20 mg). 1H-NMR(CDCl3) delta(ppm): 6.96(1H,d,J=9.7Hz), 7.34(1H,d,J=8.4Hz), 7.42-7.48(3H,m), 7.54(1H,t,J=8.4Hz),7.94(2H,d,J=6.3Hz), 8.29(1H,d,J=9.7Hz).
With pyridine; In water; SYNTHETIC EXAMPLE 20b 4-Chloro-N-(5-chloroquinoline-2-yl)-benzenesulfonamide Pyridine (1 ml) and 4-chlorobenzenesulfonyl chloride (255 mg) were added to <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (119mg, Production Example 2b) at room temperature, followed by stirring at room temperature for 3 days. Then, water was added thereto, followed by extracting with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate and concentrated. Then, the resulting solid was washed with methanol, to give the title compound (20 mg). 1H-NMR(CDCl3) delta (ppm): 6.96(1H, d, J=9.7 Hz), 7.34(1H, d, J=8.4 Hz), 7.42-7.48(3H, m), 7.54(1H, t, J=8.4 Hz),7.94(2H, d, J=6.3 Hz), 8.29(1H, d, J=9.7 Hz).
Reference： [1]Patent: US2003/144507,2003,A1
[2]Patent: EP1258252,2002,A1
[3]Patent: US2004/18192,2004,A1
  • 18
  • [ 68050-37-3 ]
  • [ 49584-26-1 ]
  • 4-Cyano-N-(5-chloroquinoline-2-yl)-benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 24 4-Cyano-N-(5-chloroquinolin-2-yl)-benzenesulfonamide The title compound was obtained from 3-amino-8-bromoquinoline (Preparation Example 2) and 4-cyanobenzenesulfonyl chloride by the procedure of Example 1. 1H-NMR (CDCl3) delta (ppm): 6.96 (1H, d, J=9.5 Hz), 7.35 (1H, d, J=8.7 Hz), 7.45 (1H, d, J=8.7 Hz), 7.57 (1H, t, J=8.7 Hz), 7.78 (2H, d, J=8.9 Hz), 8.10 (2H, d, J=8.9 Hz), 8.33 (1H, d, J=9.5 Hz).
Synthetic Example 24b 4-Cyano-N-(5-chloroquinoline-2-yl)-benzenesulfonamide The title compound was obtained from 3-amino-8-bromoquinoline (Production Example 2b) and 4-cyanobenzenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 6.96(1H, d, J=9.5Hz), 7.35(1H, d,J=8.7Hz), 7.45(1H, d, J=8.7Hz), 7.57(1H, t J=8.7Hz), 7.78(2H, d, J=8.9Hz), 8.10(2H, d, J=8.9Hz), 8.33(1H, d, J=9.5Hz).
SYNTHETIC EXAMPLE 24b 4-Cyano-N-(5-chloroquinoline-2-yl) -benzenesulfonamide The title compound was obtained from 3-amino-8-bromoquinoline (Production Example 2b) and 4-cyanobenzenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 6.96(1H, d, J=9.5 Hz), 7.35(1H, d, J=8.7 Hz), 7.45(1H, d, J=8.7 Hz), 7.57(1H, tJ=8.7 Hz), 7.78(2H, d, J=8.9 Hz), 8.10(2H, d, J=8.9 Hz), 8.33(1H, d, J=9.5 Hz).
Reference： [1]Patent: US2003/144507,2003,A1
[2]Patent: EP1258252,2002,A1
[3]Patent: US2004/18192,2004,A1
  • 19
  • [ 6361-22-4 ]
  • [ 68050-37-3 ]
YieldReaction ConditionsOperation in experiment
Preparation Example 2 2-Amino-5-chloroquinoline The title compound was obtained from 2-chloro-6-nitrobenzaldehyde in the same manner as in Preparation Example 1. 1H-NMR (CDCl3) delta (ppm): 5.25 (2H, bs), 6.80 (1H, d, J=9.7 Hz), 7.32 (1H, dd, J=7.5 Hz, 1.5 Hz), 7.46 (1H, t, J=7.5 Hz), 7.57 (1H, m), 8.30 (1H, d, J-=9.7 Hz, 1.0 Hz).
Production Example 2b 2-Amino-5-chloroquinoline The title compound was obtained from 2-chloro-6-nitrobenzaldehyde in the same manner as in Production Example 1b. 1H-NMR(CDCl3) delta (ppm): 5.25(2H,bs), 6.80(1H,d,J=9.7Hz), 7.32(1H,dd,J=7.5Hz,1.5Hz), 7.46(1H,t,J=7.5Hz), 7.57(1H,m), 8.30(1H,d,J=9.7Hz,1.0Hz).
PRODUCTION EXAMPLE 2b 2-Amino-5-chloroquinoline The title compound was obtained from 2-chloro-6-nitrobenzaldehyde in the same manner as in Production Example 1b. 1H-NMR(CDCl3) delta (ppm): 5.25(2H, bs), 6.80(1H, d, J=9.7 Hz), 7.32(1H, dd, J=7.5 Hz, 1.5 Hz), 7.46(1H, t, J=7.5 Hz), 7.57(1H, m), 8.30(1H, d, J=9.7 Hz, 1.0 Hz).
Reference： [1]Patent: US2003/144507,2003,A1
[2]Patent: EP1258252,2002,A1
[3]Patent: US2004/18192,2004,A1
  • 20
  • [ 347146-77-4 ]
  • [ 68050-37-3 ]
  • N-(5-Bromoquinoline-2-yl)-4-(N-ethylsulfamoyl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Synthetic Example 27b N-(5-Bromoquinoline-2-yl)-4-(N-ethylsulfamoyl)benzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 4-(N-ethylsulfamoyl)benzenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 1.14 (3H,t,J-7.5Hz), 3.01-3.09(2H,m), 7.08(1H,d, J=9.5Hz), 7.42(1H,dd,J=7.6Hz,1.3Hz), 7.49(1H,t,J=7.6Hz),7.65(1H,dd,J= 7.6Hz,1.3Hz), 7.96(2H,d,J=8.7Hz), 8.10(2H,d,J=8.7Hz), 8.31(1H,d,J=9.5Hz).
SYNTHETIC EXAMPLE 27b N-(5-Bromoquinoline-2-yl)-4-(N-ethylsulfamoyl)benzenesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 4-(N-ethylsulfamoyl)benzenesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 1.14(3H, t, J=7.5 Hz), 3.01-3.09(2H, m), 7.08(1H, d, J=9.5 Hz), 7.42(1H, dd, J=7.6 Hz, 1.3 Hz), 7.49(1H, t, J=7.6 Hz), 7.65(1H, dd, J=7.6 Hz,1.3Hz), 7.96(2H, d, J=8.7 Hz), 8.10(2H, d, J=8.7 Hz), 8.31(1H, d, J=9.5 Hz).
Reference： [1]Patent: EP1258252,2002,A1
[2]Patent: US2004/18192,2004,A1
  • 21
  • [ 347146-80-9 ]
  • [ 68050-37-3 ]
  • N-(5-Chloroquinoline-2-yl)-6-ethyl-3-pyridinesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Synthetic Example 22b N-(5-Chloroquinoline-2-yl)-6-ethyl-3-pyridinesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 6-ethyl-3-pyridinesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 1.32(3H, t, J=8.3Hz), 2.89(2H, q, J=8.3Hz), 6.97(1H, d, J=9.4Hz), 7.29(1H, d, J=8.0Hz), 7.35(1H, d, J=8.0Hz),7.44(1H, d, J=8.0Hz), 7.56(1H, t, J=8.0Hz), 8.18(1H, dd, J=8.0Hz, 2.6Hz), 8.30(1H, d, J=9.4Hz), 9.10(1H,d, J=2.6Hz).
SYNTHETIC EXAMPLE 22b N-(5-Chloroquinoline-2-yl)-6-ethyl-3-pyridinesulfonamide The title compound was obtained from <strong>[68050-37-3]2-amino-5-chloroquinoline</strong> (Production Example 2b) and 6-ethyl-3-pyridinesulfonyl chloride in the same manner as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 1.32(3H, t, J=8.3 Hz), 2.89(2H, q, J=8.3 Hz), 6.97(1H, d, J=9.4 Hz), 7.29(1H, d, J=8.0 Hz), 7.35(1H, d, J=8.0 Hz), 7.44(1H, d, J=8.0 Hz), 7.56(1H, t, J=8.0 Hz), 8.18(1H, dd, J=8.0 Hz, 2.6Hz), 8.30(1H, d, J=9.4 Hz), 9.10(1H, d, J=2.6 Hz).
Reference： [1]Patent: EP1258252,2002,A1
[2]Patent: US2004/18192,2004,A1

Tags: 68050-37-3 synthesis path| 68050-37-3 SDS| 68050-37-3 COA| 68050-37-3 purity| 68050-37-3 application| 68050-37-3 NMR| 68050-37-3 COA| 68050-37-3 structure

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Categories
Chemistry
Heterocyclic Building Blocks
Quinolines
Chemistry
Organic Building Blocks
Amines
Chemistry
Organic Building Blocks
Chlorides

Technical Information

• Alkyl Halide Occurrence • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Specialized Acylation Reagents-Vilsmeier Reagent • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Ugi Reaction
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