Structure of 69610-40-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Multistep Mechanochemical Synthesis of PZ-1190, a Multitarget Antipsychotic Agent
Canale, Vittorio ; Kaminski, Michal ; Trybala, Wojciech ; Abram, Michal ; Marciniec, Krzysztof ; Bantreil, Xavier , et al.
Abstract: A solid-state approach was used to synthesize compound PZ-1190, a multitarget ligand for serotonin and dopamine receptors with potential antipsychotic activity in rodents. Compared to the classical batch synthesis approach, the developed multistep mechanochem. protocol improved the overall yield (from 32% to 56%), reduced the reaction time (from 42 to 4 h), and decreased the use of toxic reagents and organic solvents. All synthesized intermediates and PZ-1190 were isolated in high purity by extraction without the requirement of chromatog. purification PZ-1190 was obtained in high enantiomeric purity (≥99% ee) with no impact of grinding processes on the integrity of stereocenter. The described procedures represent rare examples of mechanochem. reduction of a carboxylic function, which might open up the possibility to obtain crucial β- and γ-amino alcs. in a sustainable manner. The oxidation of an aliphatic alc. into an aldehyde using mechanochem. has also been reported for the first time. The obtained results confirmed the suitability of mechanochem. as a sustainable and efficient method of synthesizing candidates for preclin. development.
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Keywords: Azinesulfonamide derivatives ; Multistep mechanochemicalsynthesis ; Medicinal mechanochemistry ; Green chemistry ; Antipsychotic agents
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Purchased from AmBeed: 134441-93-3 ; 13139-15-6 ; 69610-40-8 ; 87691-87-0 ; 56502-01-3 ; 15761-39-4 ; 26250-84-0 ; 82010-31-9 ; 530-62-1 ; 846038-18-4 ; 198493-30-0 ; 88790-38-9 ; 13139-15-6 ; 347146-79-6
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CAS No. : | 69610-40-8 |
Formula : | C10H19NO3 |
M.W : | 201.26 |
SMILES Code : | [C@@H]1(N(C(OC(C)(C)C)=O)CCC1)CO |
MDL No. : | MFCD00066232 |
InChI Key : | BFFLLBPMZCIGRM-QMMMGPOBSA-N |
Pubchem ID : | 643448 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 14 |
Num. arom. heavy atoms | 0 |
Fraction Csp3 | 0.9 |
Num. rotatable bonds | 4 |
Num. H-bond acceptors | 3.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 57.75 |
TPSA ? Topological Polar Surface Area: Calculated from |
49.77 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
2.47 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
0.98 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
1.0 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.86 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
0.65 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.19 |
Log S (ESOL):? ESOL: Topological method implemented from |
-1.44 |
Solubility | 7.29 mg/ml ; 0.0362 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-1.61 |
Solubility | 4.9 mg/ml ; 0.0244 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-0.83 |
Solubility | 29.8 mg/ml ; 0.148 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.83 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
2.64 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 10℃; for 3h; | The 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{ [(2S)-pyrrolidin-2- yl] methoxy} quinazoline hydrochloride starting material was prepared as described below: 4-Chloro-6-hydroxy-7-methoxyquinazoline (prepared as described in the preparation of starting materials for Example 16; 2.75g, 13 mmol) was mixed with triphenylphosphine (5.13g, 19.6 mmole) and (2S)-l-tert-butoxycarbonyl)-2- (hydroxymethyl) pyrrolidine (3.94g, 19.6 mmole). Methylene chloride (85ml) was added and the mixture cooled under nitrogen in an ice/water bath. Di-tert-butyl azodicarboxylate (4. 51g, 19.6 mmole) was dissolved in methylene chloride (35ml) and added dropwise such that the internal temperature remained less than 10C. Once the addition was complete the cooling bath was removed and the reaction mixture stirred for 3 hours. The solvent was removed under vacuum and the residue purified by column chromatography eluting with methylene chloride/ethyl acetate (saturated with ammonia) (70/30) to give 4-chloro-7-methoxy-6-{ [(2S)-l-tert-butoxycarbonylpyrrolidin- 2-yl] methoxy} quinazoline as a gum (6.15g) ; Mass Spectrum : (M+H) + 394. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With diisopropyl (E)-azodicarboxylate; triphenylphosphine; In tetrahydrofuran; | Example 23 (S)-3-methoxy-4-[1-[3-methoxy-4-[N'-(2-methylphenyl)ureido]phenylacety]-2-pyrrolidinyl methoxy]benzoic Acid To a stirred solution of <strong>[617-05-0]ethyl 4-hydroxy-3-methoxybenzoate</strong> (3.00 g, 15.29 mmol), (S)-N-Boc-prolinol (3.08 g, 15.30 mmol), Ph3P (4.81 g, 18.34 mmol) in THF (50 mL) was added DIAD (3.61 mL, 18.33 mmol) at 0 C. The resulting mixture was heated under reflux 6.5 hr. After cooling to room temp, the mixture was evaporated and purified by column chromatography on silica-gel with CHCl3-MeOH (50:1, v/v) as eluent to give ethyl (S)-3-methoxy-4-[1-(tert-butoxycarbonyl)-2-pyrrolidinyl methoxy]benzoate as a gum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In chloroform; N,N-dimethyl-formamide; | (1) To a mixture of 530 mg of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1.20 g of 1-t-butoxycarbonyl-L-prolinol and 8 ml of DMF was added 200 mg of 55percent sodium hydride while the former was stirred under ice cooling. The resultant mixture was stirred for further 15 minutes. The reaction mixture was poured into ice water and acidified with acetic acid. Crystals thus precipitated were collected by filtration. The thus-obtained crystals were dissolved in chloroform. The resultant solution was washed with water and then dried over anhydrous magnesium sulfate. Chloroform was distilled off. Crystals thus obtained were washed with diethyl ether and then dried, whereby 797 mg of (2'S)-7-[(1'-t-butoxycarbonyl-2'-pyrrolidinylmethyl)oxy]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 87A (S)-N-Boc-2-Formyl-pyrrolidine STR115 (S)-N-Boc-2-Formyl-pyrrolidine was prepared by Swern oxidation of (S)-N-Boc prolinol (Fluka) according to the conditions described by M. G. B. Drew et al., J. Chem. Soc. Perkin 1, 1998, 1627, for the oxidation of CBZ-prolinol. |