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Chemical Structure| 73178-23-1 Chemical Structure| 73178-23-1

Structure of 73178-23-1

Chemical Structure| 73178-23-1

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Product Details of [ 73178-23-1 ]

CAS No. :73178-23-1
Formula : C14H12INO
M.W : 337.16
SMILES Code : O=C(NCC1=CC=CC=C1)C2=CC=CC=C2I
MDL No. :MFCD00297651

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Application In Synthesis of [ 73178-23-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73178-23-1 ]

[ 73178-23-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 36517-91-6 ]
  • [ 73178-23-1 ]
  • [ 1384384-77-3 ]
YieldReaction ConditionsOperation in experiment
69% With caesium carbonate; copper(l) chloride; In acetonitrile; at 90℃; for 4.5h; 2-iodobenzamide 1a (0.261 g, 1 mmol), 1,3-indanedione 2a (0.219 g, 1.5 mmol), cesium carbonate (0.39 g, 1.2 mmol) in a 50 mL round bottom flask.Add 10-15 mL of acetonitrile and heat it in an oil bath preheated to 90 C for 5 minutes.Copper chloride (6.7 mg, 5 mol%) was added and a reflux tube was placed, and the reaction was terminated by a TLC sheet. After the reaction was completed, the mixture was returned to room temperature, and 1-2 mL of saturated brine was added thereto, followed by concentration and concentration to remove acetonitrile. After adding iced saturated brine to solidify the product, gravity has passedFiltration and washing with water gave the pure product compound (1). Weighing 199 mg, the yield was 76%.
 

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