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Chemical Structure| 74385-37-8 Chemical Structure| 74385-37-8

Structure of 74385-37-8

Chemical Structure| 74385-37-8

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Product Details of [ 74385-37-8 ]

CAS No. :74385-37-8
Formula : C9H9FO3
M.W : 184.16
SMILES Code : COC(=O)C1=CC(OC)=C(F)C=C1
MDL No. :MFCD06203732
Boiling Point : No data available
InChI Key :BKTVDAXZKFVQPF-UHFFFAOYSA-N
Pubchem ID :592847

Safety of [ 74385-37-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 74385-37-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74385-37-8 ]

[ 74385-37-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 74385-37-8 ]
  • [ 128495-45-4 ]
YieldReaction ConditionsOperation in experiment
100% With lithium aluminium tetrahydride; In tetrahydrofuran; at 0℃; for 1h; To a solution of methyl 4-fluoro-3-methoxy benzoate (8.3 g, 45 mmol) in tetrahydrofuran (30 mL), LiAlH4(3.42 g, 90 mmol) was added. The reaction mixture was stirred at 0 C for 1 h, and then saturated sodium sulfate solution was added dropwise. The mixture was filtered, and the filtrate was concentrated under vacuum to give the title compound (7.1 g, 100 %). 1H NMR (CDCl3): δ 7.06-7.00 (2H, m), 6.81-6.83 (1H, m), 4.63 (2H, s), 3.89 (3H, s), 1.90 (1H, s)
100% With lithium aluminium tetrahydride; In tetrahydrofuran; at 0℃; for 1h; To a solution of methyl 4-fluoro-3-methoxy benzoate (8.3 g, 45 mmol) in tetrahydrofuran (30 mL), LiAlH4(3.42 g, 90 mmol) was added. The reaction mixture was stirred at 0 C. for 1 h, and then saturated sodium sulfate solution was added dropwise. The mixture was filtered, and the filtrate was concentrated under vacuum to give the title compound (7.1 g, 100%). 1H NMR (CDCl3): δ7.06-7.00 (2H, m), 6.81-6.83 (1H, m), 4.63 (2H, s), 3.89 (3H, s), 1.90 (1H, s).
 

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