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Chemical Structure| 7486-94-4 Chemical Structure| 7486-94-4

Structure of 7486-94-4

Chemical Structure| 7486-94-4

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Product Details of [ 7486-94-4 ]

CAS No. :7486-94-4
Formula : C5H7NO
M.W : 97.12
SMILES Code : O=C1NC(C=C)C1

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Application In Synthesis of [ 7486-94-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7486-94-4 ]

[ 7486-94-4 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 7486-94-4 ]
  • [ 6608-47-5 ]
  • 1-ethenesulfonyl-4-vinyl-azetidin-2-one [ No CAS ]
  • 3
  • [ 7486-94-4 ]
  • [ 615-37-2 ]
  • 4-[2-(2-methylphenyl)-vinyl]-azetidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With triethylamine;bis(tri-t-butylphosphine)palladium(0); In DMF (N,N-dimethyl-formamide); at 80℃; for 2h; Bis (tri-t-butylphosphin) palladium (26 mg; 0.05 MMOL) ; 4-vinyl-azetidin-2-one (0.107 ml ; 1.1 MMOL) ; 2-iodotoluene (0.128 ml ; 2.0 MMOL) and TEA (0.280 ml ; 2 MMOL) were mixed in dry DMF under N2 in a dry vial. The reaction mixture was shaken for 2 hours at 80C., filtered, and evaporated in vacuo. The residue was purified on a silica gel column using ethyl acetate as eluent, to give compound 54B as white crystals. Yield 0.119 g (63 %). MP : 95.8- 96. 5C. H NMR (CDCl3) : D : 7. 43 (m; 1 H) ; 7.18 (m; 3H); 6.85 (d; J = 15.56 Hz; 1 H) ; 6.17 (br s ; 1 H) ; 6.13 ( (D, d; J= 15.56 ; 7.78Hz ; 1H) ; 4.34 (m; 1H) ; 3.31 (ddd; J= 14.87 ; 5.21 ; 2.26 Hz; 1H) ; 2.83 (ddd; J = 14.93 ; 2.51 ; 1.38 Hz; 1H) ; 2.34 (s; 3H). 3C-NMR (CDCI3) A 167.58 ; 135.55 ; 134.94 ; 130.44 ; 130.20 ; 129.97 ; 128.05 ; 126.24 ; 125.72 ; 49.62 ; 45.59 ; 19.76. HPLC-MS (method B): m/z = 188 (M + 1).
 

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