Name: 75318-43-3|4,5-Dichloro-1,2,3-dithiazol-1-ium chloride|95%
Brand: Ambeed
SKU: A649186
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1
[ 107-14-2 ]
[ 75318-43-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	With disulfur dichloride In dichloromethane at 20℃; for 51h; Inert atmosphere;
85%	With disulfur dichloride In dichloromethane for 16h;
85%	With disulfur dichloride In dichloromethane at 20℃; for 18h;	Disulfur dichloride (10 mL, 158 mmol) was added to a solution of 2- chloroacetonitrile (4.0 mL, 64 mmol) in CH2Cl2 (13 mL) at room temperature under an inert atmosphere of argon. The resulting mixture was stirred at room temperature for 18 h. The precipitate was collected by filtration, washed with CH2Cl2 copiously, and then dried to afford 4,5-dichloro-l ,2,3-dithiazol-l-ium chloride (1 1.1 g, yield: 85%). MS (ESI) calcd for C2Cl3NS2 (m/z): 208.52, found: 248.0 [M+K]+, 206.8 [M-2]

85%	With disulfur dichloride In dichloromethane at 20℃; for 18h;	1 Preparation of 4,5-dichIoro-l,2,3-dithiazol-l-ium chloride (Appel's salt):Disulfur dichloride (10 mL, 158 mmol) was added to a solution of 2- chloroacetonitrile (4.0 mL, 64 mmol) in CH2Cl2 (13 mL) at room temperature under an inert atmosphere of argon. The resulting mixture was stirred at room temperature for 18 h. The precipitate was collected by filtration, washed with CH2Cl? copiously, and then dried to afford 4,5-dichloro-l ,2,3-dithiazol-l -ium chloride (1 1.1 g, yield: 85%). MS (ESI) calcd for C2Cl3NS2 (m/z): 208.52, found: 248.0 [M+K]+, 206.8 [M- 2]--
85%	With sulfur dichloride In dichloromethane for 18h; Cooling; Inert atmosphere;	Appel salt was prepared according to literature procedure,6d by addition of chloroacetonitrile (1 equiv) to a solution of sulfur dichloride (5 equiv) in dichloromethane (50 mL). Adogen (3-4 drops) was then added and the reaction was placed in a bowl of cold water.6b,c The mixture was left for 18 h without stirring under CaCl2 tube protection: The dark olive green solid was removed from the wall of the flask, filtered off under a blanket of argon, washed abundantly with dichloromethane and dried under vacuum for 2-3 h (average yield: 85%)
80%	With disulfur dichloride In dichloromethane at 20℃; for 18h;	Synthesis of 4,5-dichioro- 1,2,3-dithiazol- 1-lum chloride (Appel’s Salt) To a solution of chloroacetonitrile (2 mL, 31.60 mmol, 1.0 eq) in DCM (15 mL) at ambienttemperature was added sulphur monochloride (13 mL, 158.01 mmol, 5.0 eq). Thereafter, thereaction mixture was allowed to stir for a minute and then left to stand for 18 h. The resulting brown precipitate that had formed was filtered under vacuum, and washed with DCM. The brown- green solid was then dried under vacuum (5.30 g, 80%). Mp: 117-130 00.
80%	With disulfur dichloride In dichloromethane at 20℃; for 24h; Inert atmosphere;	4,5-Dichloro-1,2,3-dithiazol-1-ium chloride (Appel’s Salt). 4,5-Dichloro-1,2,3-dithiazol-1-ium chloride (Appel’s Salt).24 Sulfur monochloride (13 mL, 158 mmol, 5 eq) was added to a solution of chloroacetonitrile (2 mL, 31.6 mmol, 1 eq) in anhydrous DCM (15 mL) in an oven-dried flask equipped with a gas outlet. Thereafter, the reaction mixture was swirled for a few seconds and then left to stand, without further agitation, for 24 h at room temperature under a nitrogen atmosphere. The resulting brown precipitate that had formed was filtered under vacuum and washed copiously with DCM (3 x 200 mL) to afford Appel’s salt as a brown-green solid (5.30 g, 80%). Mp 117-130 oC. MS (ESI+): m/z Calculated for C2Cl3NS2 [M+H] 207.8616, found 207.8610.
77%	With disulfur dichloride; Adogen(R) 464 In dichloromethane at 20℃;
75%	With sulfur monochloride In dichloromethane for 72h; Inert atmosphere;	1.1 1. Preparation of Appel SaltA 500-mL round-bottomed flask was charged with chloroacetonitrile (20 mL), sulfur monochloride (120 mL), and CH2CI2 (110 mL) under argon. The reaction stirred under argon for 3 days while a brown precipitate formed. The precipitate was collected by suction filtration and washed with CH2CI2 (300 mL) and hexanes (300 mL). The washed solid was vacuum dried to give the product as a brown solid (75% yield).
75%	With disulfur dichloride In dichloromethane at 20℃; for 72h; Inert atmosphere;	1 Example 1 Under nitrogen,Add 20 mL of chloroacetonitrile and 120 mL of dithio-dichloride to the vial110 mL of methylene chloride in a 500 mL flask and reacted at room temperature for about 72 hours. Upon completion of the reaction, a brown solid precipitated. The solid was collected by suction filtration and the filter cake was washed with methylene chloride and n-hexane, respectively, and dried in vacuo to give a brown solid49.7 g of 4,5-dichloro-1,2,3-dithiazole chloride was used for the next reaction in a yield of 75%.
65%	With disulfur dichloride In dichloromethane at 20℃; for 12h;
	With disulfur dichloride
	With disulfur dichloride In dichloromethane at 20℃; for 18h; Inert atmosphere;	49.A Example 49 9-[4-(l-Amino-cvclobutyl -phenyn-2-phenyl-9H-purine-8-carbonitrile Step A: Disulfurdichloride (6.6 mL, 101 mmol) was added to a solution of 2- chloroacetonitrile (3.0 g, 40.2 mmol) in CH2C12 (10 mL) at room temperature, under an insert atomosphere of nitrogen, the resulting mixture was stirred at room temperature for 18 hours.the reaction mixture was concentrated in vacuo to get crude product 4,5-Dichloro-[l,2,3]dithiazol-l- ylium chloride (8 g crude) which was used without purification.
	With disulfur dichloride

Reference： [1]McCutcheon, David C.; Porterfield, William B.; Prescher, Jennifer A. [Organic and Biomolecular Chemistry, 2015, vol. 13, # 7, p. 2117 - 2121]
[2]Appel, Rolf; Janssen, Heinrich; Siray, Mustafa; Knoch, Falk [Chemische Berichte, 1985, vol. 118, # 4, p. 1632 - 1643]
[3]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2008/100423, 2008, A1 Location in patent: Page/Page column 89-90
[4]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2009/14674, 2009, A1 Location in patent: Page/Page column 82
[5]Hédou, Damien; Deau, Emmanuel; Harari, Marine; Sanselme, Morgane; Fruit, Corinne; Besson, Thierry [Tetrahedron, 2014, vol. 70, # 35, p. 5541 - 5549]
[6]Current Patent Assignee: UNIVERSITY OF CAPE TOWN - WO2019/21202, 2019, A1 Location in patent: Page/Page column 26
[7]Rylands, Marwaan; Jardine, Anwar [Arkivoc, 2021, vol. 2020, p. 176 - 189]
[8]Jeon, Moon-Kook; Kim, Dong-Su; Hyun, Ju La; Ha, Deok-Chan; Gong, Young-Dae [Tetrahedron Letters, 2005, vol. 46, # 44, p. 7477 - 7481]
[9]Current Patent Assignee: DANAHER CORP - WO2011/8912, 2011, A1 Location in patent: Page/Page column 31
[10]Current Patent Assignee: FOSHAN XILONG CHEMICAL - CN106883184, 2017, A Location in patent: Paragraph 0009
[11]Koutentis, Panayiotis A. [Molecules, 2005, vol. 10, # 2, p. 346 - 359]
[12]Mayer, Roland [Phosphorus and Sulfur and the Related Elements, 1985, vol. 23, p. 277 - 296]
[13]Current Patent Assignee: ROCHE HOLDING AG; PFIZER INC - WO2013/78254, 2013, A1 Location in patent: Paragraph 00291
[14]Kalogirou, Andreas S.; Koutentis, Panayiotis A. [Molecules, 2015, vol. 20, # 8, p. 14576 - 14594]

2
[ 75318-43-3 ]
[ 65573-12-8 ]

Yield	Reaction Conditions	Operation in experiment
91%	With water; dimethyl sulfoxide In acetonitrile at 20℃; for 2h;
89%	With formic acid In neat (no solvent) at 20℃; for 2h;	3.4.1. Reaction of 4,5-Dichloro-1,2,3-dithiazolium Chloride (2) with Formic Acid Appel’s salt 2 (208 mg, 1.00 mmol) was added to a stirred solution of HCO2H (98%, 1 mL), and the solution was stirred at ca. 20 °C, protected with a CaCl2 drying tube, until complete consumption of the starting material (2 h). The mixture was then adsorbed onto silica, and chromatography (n-hexane/DCM, 60:40) gave 4-chloro-5H-1,2,3-dithiazol-5-one (9) (137 mg, 89%) as pale yellow plates, mp 35-36 °C (from pentane, lit. [17] 39 °C); Rf 0.48 (n-hexane/DCM, 60:40); δC (75 MHz; CDCl3) 183.3 (s), 147.0 (s); νmax/cm-1 1651s (C=O), 1612m, 1501m, 1337w, 1142w, 1021m, 1080w, 847m, 837m, 806w, 785m, identical to an authentic sample [17].
84%	With dimethyl sulfoxide In acetonitrile at 20℃; for 1h;

72%	With sodium nitrate In dichloromethane for 16h; Heating;
	With formic acid at 20℃; for 2h;

Reference： [1]Location in patent: scheme or table Kalogirou, Andreas S.; Koutentis, Panayiotis A. [Tetrahedron, 2009, vol. 65, # 34, p. 6855 - 6858]
[2]Kalogirou, Andreas S.; Koutentis, Panayiotis A. [Molecules, 2015, vol. 20, # 8, p. 14576 - 14594]
[3]Location in patent: scheme or table Kalogirou, Andreas S.; Koutentis, Panayiotis A. [Tetrahedron, 2009, vol. 65, # 34, p. 6855 - 6858]
[4]Appel, Rolf; Janssen, Heinrich; Siray, Mustafa; Knoch, Falk [Chemische Berichte, 1985, vol. 118, # 4, p. 1632 - 1643]
[5]Maffuid, Kaitlyn A.; Koyioni, Maria; Torrice, Chad D.; Murphy, William A.; Mewada, Heemaja K.; Koutentis, Panayiotis A.; Crona, Daniel J.; Asquith, Christopher R.M. [Bioorganic and Medicinal Chemistry Letters, 2021, vol. 43]

3
[ 75318-43-3 ]
[ 1614-12-6 ]
benzotriazol-1-yl-(4-chloro-<1,2,3>dithiazol-5-ylidene)-amine [ No CAS ]

Reference： [1]Tetrahedron,1994,vol. 50,p. 10037 - 10046

4
[ 26961-27-3 ]
[ 75318-43-3 ]
N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4,5-dimethoxyanthranilonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With pyridine In dichloromethane for 0.5h; Ambient temperature;
76%	With pyridine In dichloromethane Ambient temperature;
	With pyridine In dichloromethane Ambient temperature;

Reference： [1]Besson, Thierry; Emayan, Kumaraswamy; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1995, # 17, p. 2097 - 2102]
[2]Besson, Thierry; Rees, Charles W.; Cottenceau, Gilles; Pons, Anne-Marie [Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 19, p. 2343 - 2348]
[3]Besson, Thierry; Emayan, Kumaraswamy; Rees, Charles W. [Journal of the Chemical Society. Chemical communications, 1995, # 14, p. 1419 - 1420]

5
[ 75318-43-3 ]
[ 371-40-4 ]
(Z)-4-chloro-N-(4-fluorophenyl)-5H-1,2,3-dithiazol-5-imine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine 1) CH₂Cl₂, 2 h, room temperature; 2) CH₂Cl₂, 2 h, room temperature; Yield given. Multistep reaction;
	With pyridine 1) CH₂Cl₂, rt, 2 h; 2) CH₂Cl₂, rt, 2 h; Multistep reaction;
	In dichloromethane at 20℃; for 2h;

Stage #1: 4,5-dichloro-1,2,3-dithiazol-1-ium chloride; 4-fluoroaniline In dichloromethane at 20℃; for 1h; Stage #2: With pyridine In dichloromethane at 20℃; for 2h;

General method for the synthesis of 4-chloro-1,2,3-dithiazoles (8-39). General procedure: To a stirred suspension of 4,5-dichloro-1,2,3-dithiazolium chloride (Appel’s salt) (6)51a (100 mg, 0.48 mmol) in dichloromethane (4 mL) at ca. 20°C, the corresponding arylamine (0.48 mmol) was added. After 1 h, pyridine (77.3 μL, 0.96 mmol) was added to the reaction mixture dropwise. After a further 2 h the reaction mixture was adsorbed onto silica and purified by dry flash chromatography to afford the corresponding (Z)-4-chloro-N-aryl-5H-1,2,3-dithiazol-5-imine. Compounds 7-9,45 and 11-15,45 25-2645 and 35-3851l were consistent with literature reports.

Reference： [1]Besson, Thierry; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1995, # 13, p. 1659 - 1662]
[2]Beneteau, Valerie; Besson, Thierry; Rees, Charles W. [Synthetic Communications, 1997, vol. 27, # 13, p. 2275 - 2280]
[3]Frère, Stéphane; Thiéry, Valérie; Bailly, Christian; Besson, Thierry [Tetrahedron, 2003, vol. 59, # 6, p. 773 - 779]
[4]Asquith, Christopher R. M.; Hofmann-Lehmann, Regina; Koutentis, Panayiotis A.; Koyioni, Maria; Laitinen, Tuomo; Meili, Theres; Poso, Antti [Bioorganic and Medicinal Chemistry, 2022, vol. 68]

6
[ 26961-27-3 ]
[ 75318-43-3 ]
2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-4,5-dimethoxybenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With pyridine In dichloromethane for 2h; Ambient temperature;
76%	Stage #1: 2-amino-4,5-dimethoxybenzonitrile; 4,5-dichloro-1,2,3-dithiazolium chloride In dichloromethane at 20℃; for 1h; Stage #2: With pyridine In dichloromethane at 20℃;

Reference： [1]Cottenceau, Gilles; Besson, Thierry; Gautier, Valerie; Rees, Charles W.; Pons, Anne-Marie [Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 5, p. 529 - 532]
[2]Location in patent: experimental part Michaelidou, Sophia S.; Koutentis, Panayiotis A. [Synthesis, 2009, # 24, p. 4167 - 4174]

7
[ 68817-71-0 ]
[ 75318-43-3 ]
N-[4-Chloro-[1,2,3]dithiazol-(5Z)-ylidene]-N'-(4-chloro-phenyl)-benzene-1,2-diamine [ No CAS ]

Reference： [1]Tetrahedron Letters,1996,vol. 37,p. 4589 - 4592

8
[ 75318-43-3 ]
[ 95-55-6 ]
(Z)-2-((4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino)phenol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	In dichloromethane for 0.3h; Ambient temperature;
95%	Stage #1: 4,5-dichloro-1,2,3-dithiazolium chloride; 2-amino-phenol In dichloromethane at 20℃; for 1h; Stage #2: With pyridine In dichloromethane at 20℃; for 2h;
76%	With pyridine In dichloromethane at 20℃; Inert atmosphere;	4.4. Synthesis of benzo[d]oxazole-2-carbonitriles (13 and 14) General procedure: 4.4. Synthesis of benzo[d]oxazole-2-carbonitriles (13 and 14)4,5-Dichloro-1,2,3-dithiazolium chloride (4.066 g, 19.5 mmol)was added portionwise to a stirred solution of the appropriateaminophenol (15 mmol) in freshly distilled methylene chloride(115 mL) at room temperature. The dark mixture was vigorouslyagitated for 3 h. Pyridine (30 mmol, 2.42 mL) was added dropwiseto the solution, which was further agitated for another 2 h. Thereaction mixture was quenched with water. The organic layer wasseparated and dried over magnesium sulfate and evaporated todryness in vacuo. (Z)-2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)phenol was purified by flash chromatography usingpetroleum ether/methylene chloride (100:0 to 0:100, v/v) or directlyengaged in the cyclization step.(Z)-2-(4-Chloro-5H-1,2,3-dithiazol-5-ylideneamino)phenol wasdissolved in toluene (50 mL) and vigorously refluxed for 3 h. Thereaction mixture was evaporated in vacuo. Purification of the residueby flash chromatography using petroleum ether/methylenechloride (100:0 to 0:100, v/v) afforded the corresponding benzo[d]oxazole-2-carbonitriles.4.4.1. (Z)-2-(4-Chloro-5H-1,2,3-dithiazol-5-ylideneamino)phenol(11). Yield 76% (3.71 g), yellow solid, mp183e185 C; IR (cm1)ymax 3385,1661,1608,1583,1472,1444,1339,1286,1254,1219,1135,1033, 951, 854, 807, 744, 730, 674; 1H NMR (300 MHz, DMSO-d6)d 9.46 (br s, 1H, OH), 7.12e7.03 (m, 1H, Har), 7.02e6.94 (m, 2H, Har),6.87 (td, J7.8,1.4 Hz, 1H, Har); 13C NMR (75 MHz, DMSO-d6) d 160.7,148.0, 147.2, 139.4, 127.4, 120.3, 119.8, 117.3; HRMS calcd forC8H5N2O [MH] 244.9610, found 244.9607.4.4.2. Benzo[d]oxazole-2-carbonitrile (13). Yield 61% (1.317 g), colourlesssolid, mp102e104 C; IR (cm1) ymax 2249, 1530, 1475,1443, 1338, 1256, 1169, 1102, 950, 893, 817, 759, 748, 685, 620; 1HNMR (300 MHz, DMSO-d6) d 8.00 (d, J8.0 Hz, 1H, Har), 7.94 (d,J8.3 Hz, 1H, Har), 7.74e7.67 (m, 1H, Har), 7.63e7.56 (m, 1H, Har); 13CNMR (75 MHz, DMSO-d6) d 150.6, 139.4, 137.8, 129.9, 127.2, 122.0,112.4, 110.2. This compound was already described2b,5, spectrometricdata are consistent with the assigned structure.

69%	Stage #1: 4,5-dichloro-1,2,3-dithiazolium chloride; 2-amino-phenol In dichloromethane at 20℃; for 3h; Inert atmosphere; Stage #2: With pyridine In dichloromethane at 20℃; for 2h;
	In dichloromethane at 20℃; for 2h;

Reference： [1]English, Russell F.; Rakitin, Oleg A.; Rees, Charles W.; Vlasova, Olga G. [Journal of the Chemical Society. Perkin transactions I, 1997, # 3, p. 201 - 205]
[2]Kalogirou, Andreas S.; Michaelidou, Sophia S.; Koyioni, Maria; Koutentis, Panayiotis A. [Tetrahedron, 2015, vol. 71, # 39, p. 7181 - 7190]
[3]Deau, Emmanuel; Dubouilh-Benard, Carole; Levacher, Vincent; Besson, Thierry [Tetrahedron, 2015, vol. 70, # 35, p. 5532 - 5540]
[4]Ramil, Carlo P.; An, Peng; Yu, Zhipeng; Lin, Qing [Journal of the American Chemical Society, 2016, vol. 138, # 17, p. 5499 - 5502]
[5]Frère, Stéphane; Thiéry, Valérie; Bailly, Christian; Besson, Thierry [Tetrahedron, 2003, vol. 59, # 6, p. 773 - 779]

9
[ 75318-43-3 ]
[ 615-36-1 ]
(Z)-2-bromo-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97%	With pyridine In dichloromethane at 20℃; Inert atmosphere;	4.2. Synthesis of ortho-halogenated N-aryliminodithiazolesusing 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) General procedure: 4.2. Synthesis of ortho-halogenated N-aryliminodithiazolesusing 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt)4,5-Dichloro-1,2,3-dithiazolium chloride (5.421 g, 26 mmol)was added portionwise to a stirred solution of the appropriateamine (20 mmol) in freshly distilled methylene chloride (150 mL)at room temperature. The dark mixture was vigorously agitated for3 h. Pyridine (40 mmol, 3.23 mL) was added dropwise to the solution,which was further agitated for another 2 h. The reactionmixture was quenched with water. The organic layer was separatedand dried over magnesium sulfate and evaporated to drynessin vacuo. Purification of the dark brown residue by flashchromatography using petroleum ether/methylene chloride (100:0to 0:100, v/v) as eluent afforded the correspondingaryliminodithiazoles.4.2.1. (Z)-2-Bromo-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene) aniline(1). Yield 97% (5.968 g), yellow solid, mp80e82 C; IR (cm1) ymax3065, 1691, 1661, 1596, 1583, 1540, 1503, 1463, 1433, 1223, 1150,1042, 1024, 856, 848, 771, 720, 673; 1H NMR (300 MHz, DMSO-d6)d 7.76 (dd, J8.0, 0.9 Hz, 1H, H-3), 7.55e7.43 (m, 1H, Har), 7.27e7.13(m, 2H, Har); 13C NMR (75 MHz, DMSO-d6) d 163.0, 150.9, 146.8, 134.1, 130.1, 127.7, 119.2, 114.8; HRMS calcd for C8H579BrClN2S2[MH] 306.8771, found 306.8766.
91%	In dichloromethane for 1h; Ambient temperature;
	Stage #1: 4,5-dichloro-1,2,3-dithiazol-1-ium chloride; 2-bromoaniline In dichloromethane at 20℃; for 1h; Stage #2: With pyridine In dichloromethane at 20℃; for 2h;	General method for the synthesis of 4-chloro-1,2,3-dithiazoles (8-39). General procedure: To a stirred suspension of 4,5-dichloro-1,2,3-dithiazolium chloride (Appel’s salt) (6)51a (100 mg, 0.48 mmol) in dichloromethane (4 mL) at ca. 20°C, the corresponding arylamine (0.48 mmol) was added. After 1 h, pyridine (77.3 μL, 0.96 mmol) was added to the reaction mixture dropwise. After a further 2 h the reaction mixture was adsorbed onto silica and purified by dry flash chromatography to afford the corresponding (Z)-4-chloro-N-aryl-5H-1,2,3-dithiazol-5-imine. Compounds 7-9,45 and 11-15,45 25-2645 and 35-3851l were consistent with literature reports.

Reference： [1]Deau, Emmanuel; Dubouilh-Benard, Carole; Levacher, Vincent; Besson, Thierry [Tetrahedron, 2015, vol. 70, # 35, p. 5532 - 5540]
[2]English, Russell F.; Rakitin, Oleg A.; Rees, Charles W.; Vlasova, Olga G. [Journal of the Chemical Society. Perkin transactions I, 1997, # 3, p. 201 - 205]
[3]Asquith, Christopher R. M.; Hofmann-Lehmann, Regina; Koutentis, Panayiotis A.; Koyioni, Maria; Laitinen, Tuomo; Meili, Theres; Poso, Antti [Bioorganic and Medicinal Chemistry, 2022, vol. 68]

10
[ 29182-42-1 ]
[ 75318-43-3 ]
Benzothiazol-2-yl-[4-chloro-[1,2,3]dithiazol-(5Z)-ylidene]-acetic acid ethyl ester [ No CAS ]

Reference： [1]Bulletin des Societes Chimiques Belges,1997,vol. 106,p. 729 - 730

11
[ 75318-43-3 ]
[ 41381-89-9 ]
[4-Chloro-[1,2,3]dithiazol-(5Z)-ylidene]-(4-phenyl-thiazol-2-yl)-acetonitrile [ No CAS ]

Reference： [1]Bulletin des Societes Chimiques Belges,1997,vol. 106,p. 729 - 730

12
[ 37585-16-3 ]
[ 75318-43-3 ]
{4-Chloro-2-[4-chloro-[1,2,3]dithiazol-(5Z)-ylideneamino]-phenyl}-methanol [ No CAS ]

Reference： [1]Synlett,1997,vol. 1997,p. 704 - 706

13
[ 594-65-0 ]
[ 75318-43-3 ]
[ 75318-44-4 ]
2,2,2-Trichloro-N-[4-chloro-[1,2,3]dithiazol-(5Z)-ylidene]-acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 30% 2: 36%	With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h;

Reference： [1]Koutentis, Panayiotis A.; Rees, Charles W. [Journal of the Chemical Society. Perkin transactions I, 1998, # 16, p. 2505 - 2509]

14
[ 893-33-4 ]
[ 75318-43-3 ]
2-[4-Chloro-[1,2,3]dithiazol-(5Z)-ylidene]-4,4,4-trifluoro-1-naphthalen-2-yl-butane-1,3-dione [ No CAS ]

Reference： [1]Tetrahedron Letters,1998,vol. 39,p. 5781 - 5784

15
[ 68817-71-0 ]
[ 75318-43-3 ]
N-[4-Chloro-[1,2,3]dithiazol-(5Z)-ylidene]-N'-(4-chloro-phenyl)-benzene-1,2-diamine [ No CAS ]

Reference： [1]Tetrahedron,1998,vol. 54,p. 9639 - 9650

16
[ 37585-16-3 ]
[ 75318-43-3 ]
{4-Chloro-2-[4-chloro-[1,2,3]dithiazol-(5Z)-ylideneamino]-phenyl}-methanol [ No CAS ]

Reference： [1]Pharmacy and Pharmacology Communications,1998,vol. 4,p. 39 - 42

17
[ 4139-61-1 ]
[ 75318-43-3 ]
(E)-6-bromo-3-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-6-methyl-2H-1-benzopyran-2,4-dione [ No CAS ]

Reference： [1]Tetrahedron,1999,vol. 55,p. 9651 - 9667

18
[ 52119-38-7 ]
[ 75318-43-3 ]
[ 75318-44-4 ]
(Z)-ethyl 2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-3'-nitrobenzoylacetate [ No CAS ]
(E)-ethyl 2-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-3'-nitrobenzoylacetate [ No CAS ]

Reference： [1]Tetrahedron,1999,vol. 55,p. 9651 - 9667

19
[ 139-65-1 ]
[ 75318-43-3 ]
Bis[4-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)phenyl]sulfide [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2000,p. 563 - 566

20
[ 6154-04-7 ]
[ 75318-43-3 ]
(4-chloro-[1,2,3]dithiazol-5-ylidene)-(2-methyl-2<i>H</i>-tetrazol-5-yl)-amine [ No CAS ]

Reference： [1]Tetrahedron Letters,2000,vol. 41,p. 9407 - 9411

21
[ 16687-60-8 ]
[ 75318-43-3 ]
C₉H₄Cl₂N₄O₂S₂ [ No CAS ]

Reference： [1]Tetrahedron Letters,2000,vol. 41,p. 9407 - 9411

22
[ 16687-60-8 ]
[ 75318-43-3 ]
4-Chloro-5-[5-(4-nitro-phenyl)-tetrazol-2-yl]-[1,2,3]dithiazol-1-ylium; chloride [ No CAS ]

Reference： [1]Tetrahedron Letters,2000,vol. 41,p. 9407 - 9411

23
[ 32566-01-1 ]
[ 75318-43-3 ]
[ 311330-16-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2000,vol. 10,p. 2183 - 2185

24
[ 6154-04-7 ]
[ 75318-43-3 ]
5-(4-chloro-5H-1,2,3-dithiazol-5-ylimino)-2-methyltetrazole [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,p. 1535 - 1542

25
[ 5334-41-8 ]
[ 75318-43-3 ]
(4-chloro-[1,2,3]dithiazol-5-ylidene)(1-methyl-4-cyanopyrazol-5-yl)amine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2002,vol. 10,p. 449 - 456

26
[ 16687-60-8 ]
[ 75318-43-3 ]
3-chloro-1-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-3-(4-nitrophenyl)-1,2-diazaprop-2-ene [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin Transactions 1 (2001),2002,p. 1535 - 1542

27
[ 75318-43-3 ]
[ 158001-28-6 ]
(4-chloro-[1,2,3]dithiazol-5-ylidene)(1-tert-butyl-4-cyanopyrazol-5-yl)amine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2002,vol. 10,p. 449 - 456

28
[ 6168-72-5 ]
[ 27329-27-7 ]
[ 75318-43-3 ]
3,8-dimethyl-2,3-dihydrooxazolo[2,3-b]quinazolin-5-one [ No CAS ]