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[ CAS No. 760-58-7 ]

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2D
Chemical Structure| 760-58-7
Chemical Structure| 760-58-7
Structure of 760-58-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 760-58-7 ]

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Related Doc. of [ 760-58-7 ]

SDS

Product Details of [ 760-58-7 ]

CAS No. :760-58-7MDL No. :MFCD22377852
Formula :C7H9NO2Boiling Point :283.1°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :139.15Pubchem ID :-
Synonyms :

Computed Properties of [ 760-58-7 ]

TPSA : 61.1 H-Bond Acceptor Count : 3
XLogP3 : 1.3 H-Bond Donor Count : 1
SP3 : 0.43 Rotatable Bond Count : 2

Safety of [ 760-58-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P280UN#:N/A
Hazard Statements:H302+H312+H332Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 760-58-7 ]

  • Upstream synthesis route of [ 760-58-7 ]
  • Downstream synthetic route of [ 760-58-7 ]

[ 760-58-7 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 372-09-8 ]
  • [ 78-84-2 ]
  • [ 760-58-7 ]
YieldReaction ConditionsOperation in experiment
83% With ammonium acetate In tolueneReflux Step 1 - 2-Cyano-4-methyl-2-pentenoic acidA stirred suspension of cyanoacetic acid (42.5g, 0.5 mol), ammonium acetate(1 .56g, 0.02 mol, 4 molpercent) and isobutyraldehyde (55ml, 39.66g, 0.55 mol, 1 .1 eq) in toluene (130ml) was heated to reflux with Dean-Stark removal of water. When generation of water ceased, the reaction mixture was cooled to room temperature and concentrated under reduced pressure to give a yellow solid (79.5g). Hexane (150ml) was added and the suspension was stirred at 400rpm for 1 hour. The solid was filtered, washed with hexane (2 x 50ml) and dried to provide the title compound as a yellow crystalline solid (58.5g, 83percent yield).
11.2 g
Stage #1: for 30.00 h;
Stage #2: With piperidine In methanol for 1.00 h;
To a solution of 2-cyanoacetic acid (8.7g, 102 mmol) in methanol (200mL) was added 2-methylpropanal (18.6 mL, 204 mmol) and the solution was stirred with a slight exotherm noted. After 30 minutes, added piperidine (1 1.1 mL, 1 12 mmol) and continued stirring for 1 h before removing solvent in vacuo with gentle heating. The thick material was diluted with ether and washed with 125mL of 1.0M HC1 and then washed with brine. The organic phase was dried over sodium sulfate and concentrated to afford a colorless oil weighing 11.2 g of 2- cyano-4-methylpent-2-enoic acid which precipitated on standing.
Reference: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 109 - 121
[2] Patent: WO2012/25861, 2012, A1. Location in patent: Page/Page column 22
[3] Journal of the Chemical Society, 1932, p. 445,453[4] Journal of the Chemical Society, 1933, p. 613
[5] Patent: WO2014/39899, 2014, A1. Location in patent: Page/Page column 52
[6] Journal of Molecular Catalysis B: Enzymatic, 2014, vol. 101, p. 67 - 72
  • 2
  • [ 372-09-8 ]
  • [ 590-86-3 ]
  • [ 760-58-7 ]
Reference: [1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 8, p. 1878 - 1882
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