There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 766-80-3 | MDL No. : | MFCD00000597 |
Formula : | C7H6BrCl | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LZIYAIRGDHSVED-UHFFFAOYSA-N |
M.W : | 205.47 | Pubchem ID : | 69838 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P280-P305+P351+P338-P310 | UN#: | 3265 |
Hazard Statements: | H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With sodium bromate; 2,2'-azobis(isobutyronitrile); sulfuric acid; sodium bromide; dibenzoyl peroxide In dichloromethane; waterReflux | m-chlorotoluene (5.1 g, 40 mmol)Sodium bromate (2.1 g, 14 mmol), sodium bromide (2.9 g, 28 mmol)Dichloromethane (25 mL) was added to a reaction flask equipped with a stirred, reflux condenser, thermometer and tail gas absorber,Heated to reflux,(0.025 g AIBN, 0.025 g BPO dissolved in 5 mL of dichloromethane) was added rapidly to the total volume of the initiator solution,Sulfuric acid (2.1 g, 21 mmol concentrated sulfuric acid diluted with 2.5 mL of water) and the remaining initiator solution were slowly added dropwise, followed by gas chromatography,After the reaction was complete, the mixture was cooled to room temperature, saturated sodium bisulfite solution (10 mL) was added, stirred to red to fade,The aqueous phase was extracted twice with dichloromethane (10 mL x 2), the organic phases were combined and washed with saturated sodium chloride solution, dried and concentratedThe crude product was purified by column chromatography (elution solvent as petroleum ether) to give 6.8 g of m-chlorobenzyl bromide in 83percent yield. The product is colorless liquid |
70% | With Oxone; water; potassium bromide In dichloromethane at 20℃; for 20 h; Irradiation; Sealed tube | General procedure: KBr (29.8 mg, 0.25 mmol, 1.0 equiv), 1-ethyl-4-nitrobenzene (1a) (41.6 mg, 0.275 mmol, 1.1 equiv), Oxone (153.9 mg, 0.25 mmol, 1.0 equiv), CH2Cl2 (0.25 mL) and H2O (180.0 mg, 0.18 mL, 40.0 equiv) were added, in accordance with the order, to a 15-mL oven-driedtube. The reaction tube was equipped with a magnetic stir bar and sealed with a Teflon-lined cap at once after the addition of the H2O. Then, the tube was placed on a magnetic stirrer (speed 300 rpm) and irradiated with a 0.5 W LED at a distance of 5 cm for 20 h at rt. After the reaction was finished, the reaction mixture was quenched with Na2SO3. Water (15 mL) was added and the mixture extracted with CH2Cl2 (3 × 5 mL). The organic phase was combined and dried with anhydrous Na2SO4. The solvent was evaporated under reduced pressure to give the crude product that was purified by flash column chromatography (petroleum ether/EtOAc mixtures). Compound 3a was obtained as a light yellow solid; yield: 53.6 mg (93percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | at 80℃; for 2 h; | Example 257; 2-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-(1-(3-chlorophenyl)cyclopropyl)-1,3,4-oxadiazole; Step 1: 2-(3-chlorophenyl)acetonitrile; The experimental procedure was followed by the method of Bruno P. Imbimbo et al [J. Med. Chem. 2005, 48, 5707-7520]. A solution of 3-chlorobenzylbromide (5 g, 24.3 mmol) and sodium cyanide (1.3 g, 26.8 mmol) in ethanol (50 ml) was heated to 80° C. for 2 hours. After resulting solution was cooled to room temperature and concentrated under reduced pressure. The residue was suspended in water and organic layer was extracted with ethyl acetate. The solution was evaporated and crude compound was purified by silica gel column chromatography (hexane/ethyl acetate=5/1) to yield 2-(3-chlorophenyl)acetonitrile (3.2 g, 87percent yield) as colorless oil. 1H NMR (400 MHz, CDCl3) δ 7.36-7.32 (m, 1H), 7.20-7.17 (m, 3H), 7.06-7.04 (m, 1H), 3.68 (s, 2H). |
[ 7778-01-0 ]
1-(Bromomethyl)-3,5-dichlorobenzene
Similarity: 0.97
[ 622-95-7 ]
1-(Bromomethyl)-4-chlorobenzene
Similarity: 0.97
[ 57915-78-3 ]
1-(Bromomethyl)-2,3-dichlorobenzene
Similarity: 0.85
[ 20443-99-6 ]
1-(Bromomethyl)-2,4-dichlorobenzene
Similarity: 0.85
[ 7778-01-0 ]
1-(Bromomethyl)-3,5-dichlorobenzene
Similarity: 0.97
[ 622-95-7 ]
1-(Bromomethyl)-4-chlorobenzene
Similarity: 0.97
[ 57915-78-3 ]
1-(Bromomethyl)-2,3-dichlorobenzene
Similarity: 0.85
[ 20443-99-6 ]
1-(Bromomethyl)-2,4-dichlorobenzene
Similarity: 0.85
[ 7778-01-0 ]
1-(Bromomethyl)-3,5-dichlorobenzene
Similarity: 0.97
[ 622-95-7 ]
1-(Bromomethyl)-4-chlorobenzene
Similarity: 0.97
[ 57915-78-3 ]
1-(Bromomethyl)-2,3-dichlorobenzene
Similarity: 0.85
[ 20443-99-6 ]
1-(Bromomethyl)-2,4-dichlorobenzene
Similarity: 0.85
[ 7778-01-0 ]
1-(Bromomethyl)-3,5-dichlorobenzene
Similarity: 0.97
[ 622-95-7 ]
1-(Bromomethyl)-4-chlorobenzene
Similarity: 0.97
[ 57915-78-3 ]
1-(Bromomethyl)-2,3-dichlorobenzene
Similarity: 0.85
[ 20443-99-6 ]
1-(Bromomethyl)-2,4-dichlorobenzene
Similarity: 0.85