77395-10-9|5-Bromo-7-methylindoline-2,3-dione| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 77395-10-9 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 77395-10-9 ]

CAS No. :	77395-10-9
Formula :	C₉H₆BrNO₂
M.W :	240.05
SMILES Code :	O=C1NC2=C(C=C(Br)C=C2C)C1=O
MDL No. :	MFCD00463080
InChI Key :	NPRAKNSGKOICIE-UHFFFAOYSA-N
Pubchem ID :	542843

Safety of [ 77395-10-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 77395-10-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 77395-10-9 ]

[ 77395-10-9 ] Synthesis Path-Downstream 1~34

1
[ 1127-59-9 ]
[ 77395-10-9 ]

Yield	Reaction Conditions	Operation in experiment
77%	With bromine; In chloroform; at 20 - 80℃; for 24.25h;	Step 3: 5-bromo-7-methylindoline-2,3-dioneTo a stirred mixture of 7-methylindoline-2,3-dione (7 g, 0.043 mol) in chloroform (700 mL) was added a solution of bromine (2.8 mL, 0.053 mol) in chloroform (100 mL) dropwise over 15 min at room temperature. The reaction mixture was heated at 80C for 24 h and then cooled to 0C, which resulted in precipitation of the product as a red solid. The solid was collected by suction filtration and dried under vacuum to afford the title compound (8 g, 77%).XH NMR (400 MHz, DMSO-d6) : δ 11.20 (s, 1H), 7.64 (d, J = 1.2 Hz, 1H), 7.42 (d, J = 7.2 Hz, 1H), 2.18 (s, 3H); ESI-MS: Calculated mass: 238.96; Observed mass: 238.30 [M-H]".

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.
[2]Patent: WO2014/169167,2014,A1 .Location in patent: Page/Page column 81.
[3]Bulletin de la Societe Chimique de France,1946,p. 586,587.
[4]Journal of Medicinal Chemistry,2007,vol. 50,p. 21 - 39.

2
hydroxyimino-acetic acid-(4-bromo-2-methyl-anilide) [ No CAS ]
[ 77395-10-9 ]

References: [1]Bulletin de la Societe Chimique de France,1923,vol. <4>33,p. 639.

3
[ 77395-10-9 ]
[ 206548-13-2 ]

Yield	Reaction Conditions	Operation in experiment
75%	With dihydrogen peroxide; sodium chloride; sodium hydroxide; In water; at 0℃; for 1.5h;	Step 4: 2-amino-5-bromo-3-methylbenzoic acidA mixture of <strong>[77395-10-9]5-bromo-7-methylindoline-2,3-dione</strong> (8 g, 0.033 mol), sodium chloride (4.5 g, 0.09 mol) and sodium hydroxide (3.6 g, 0.09 mol) was dissolved in water (96 mL) with stirring to give a yellow solution. The reaction mixture was cooled to 0C and to this mixture was added slowly a solution of 30% hydrogen peroxide (7 mL) and .sodium hydroxide (6.27 g) in 83 mL of water. The reaction mixture was stirred for another 1.5 h at 0C and then quenched with glacial acetic acid to give a tan precipitate. The solid was filtered, washed thoroughly with cold water and dried under vacuum to afford the title compound (5.8 g, 75%).XH NMR (400 MHz, DMSO-d6) : δ 7.69 (d, J = 2.4 Hz, 1H), 7.26 (s, 1H), 2.0 (s, 3H); ESI-MS : Calculated mass: 228.97; Observed mass: 228.10 [M-H]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.
[2]Patent: WO2014/169167,2014,A1 .Location in patent: Page/Page column 81; 82.

4
[ 77395-10-9 ]
[ 39561-82-5 ]
C₁₇H₁₁BrClNO₃ [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 21 - 39.

5
2-hydroxyimino-<i>N</i>-<i>o</i>-tolyl-acetamide [ No CAS ]
[ 77395-10-9 ]

References: [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 21 - 39.

6
[ 95-53-4 ]
2.5.6.1¹.3¹-pentabromo-4-acetoxy-1.3-dimethyl-benzene [ No CAS ]
[ 77395-10-9 ]

References: [1]Journal of Medicinal Chemistry,2007,vol. 50,p. 21 - 39.
[2]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.

7
(E)-2-(hydroxyimino)-N-(o-tolyl)acetamide [ No CAS ]
[ 77395-10-9 ]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.
[2]Patent: WO2014/169167,2014,A1 .

8
[ 77395-10-9 ]
[ 908597-10-4 ]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.

9
[ 77395-10-9 ]
[ 908597-09-1 ]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.

10
[ 77395-10-9 ]
dimethyl 4,4'-dibromo-6,6'-dimethyl[1,1'-biphenyl]-2,2'-dicarboxylate [ No CAS ]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.
[2]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.

11
[ 77395-10-9 ]
[ 908597-02-4 ]

References: [1]Journal of Organic Chemistry,2006,vol. 71,p. 5921 - 5929.

12
[ 583-75-5 ]
[ 77395-10-9 ]

References: [1]Bulletin de la Societe Chimique de France,1923,vol. <4>33,p. 639.
[2]Patent: WO2017/62581,2017,A1 .
[3]Tetrahedron,2018,vol. 74,p. 1294 - 1306.

13
[ 1189051-96-4 ]
[ 77395-10-9 ]

References: [1]Tetrahedron,2009,vol. 65,p. 7357 - 7363.

14
[ 77395-10-9 ]
[ 68014-21-1 ]
[ 1373943-25-9 ]

References: [1]Organic Letters,2012,vol. 14,p. 2512 - 2515.

15
[ 95-53-4 ]
[ 77395-10-9 ]

References: [1]Patent: WO2014/169167,2014,A1 .
[2]Patent: WO2022/64454,2022,A1 .

16
[ 77395-10-9 ]
6-bromo-8-methylquinazoline-2,4( 1H,3H)-dione [ No CAS ]