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Chemical Structure| 78210-43-2 Chemical Structure| 78210-43-2

Structure of 78210-43-2

Chemical Structure| 78210-43-2

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Product Details of [ 78210-43-2 ]

CAS No. :78210-43-2
Formula : C11H10N2
M.W : 170.21
SMILES Code : C1(CC2=CC=CN=C2)=CC=CN=C1
MDL No. :MFCD14706782

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Application In Synthesis of [ 78210-43-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 78210-43-2 ]

[ 78210-43-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 54221-96-4 ]
  • [ 78210-43-2 ]
  • [ 875651-57-3 ]
YieldReaction ConditionsOperation in experiment
47% LiHMDS (2.45 mL, 1.2 M in THF, 2.94 mmole) was added to a flame-dried round bottom flask. The mixture was cooled to 00C then <strong>[54221-96-4]6-methoxypyridine-2-carbaldehyde</strong> (Comins, Daniel L.; Killpack, Michael O. J.Org.Chem. 1990, 55, 69-73, 161 mg, 1.18 mmole) was added. After 30 minutes di-3-pyridylmethane (200 mg, 1.18 mmole) in dry THF (2.0 mL) was added. After 2 hr the mixture was warmed to RT, quenched with saturated NH4Cl, and extracted with CH2Cl2(3x) and iBuOH (2x). The combined organic layers were dried (MgSO4), filtered, and concentrated. The residue was taken up in MeOH (5 mL) and H2NOH (0.4 mL, 50percent in H2O) was added. After 18 hr the mixture was concentrated. Flash column (gradient, 0-10percent MeOH/CH2Cl2) gave l-(6-methoxypyridin-2-yl)-2,2-dipyridin-3- ylethanamine as a pale yellow oil (168 mg, 47percent): 1H-NMR (500 MHz, CDCl3) delta 8.64 (d, J = 1.95 Hz, 1 H), 8.51 (dd, J = 1.46 and 3.17 Hz, 1 H), 8.36 (d, J = 1.95 Hz, 1 H), 8.32 (dd, J = 1.46 and 3.18 Hz, 1 H), 7.76 (d, J = 7.82 Hz, 1 H), 7.49 (d, J = 8.06 Hz, 1 H), 7.37-7.27 (m, 2 H), 7.09 (m, 1 H), 6.56 (d, J = 7.08 Hz, 1 H), 6.52 (d, J = 7.81 Hz, 1 H), 4.59 (d, J = 9.28 Hz, 1 H), 4.42 (d, J = 9.28 Hz, 1 H), 3.91 (s, 3 H).
 

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