[ CAS No. 827586-90-3 ] {[proInfo.proName]}

Name: 827586-90-3|3-(Trifluoromethoxy)pyridin-4-amine|97%
Brand: Ambeed
SKU: A758377
Rating: 90 (32 reviews)

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Cat. No.: {[proInfo.prAm]}

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Structure of 827586-90-3 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 827586-90-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 827586-90-3 ]

SDS Specification

Alternatived Products of [ 827586-90-3 ]

Product Details of [ 827586-90-3 ]

CAS No. :	827586-90-3	MDL No. :	MFCD19690275
Formula :	C₆H₅F₃N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QVXXNMHZXMHXJZ-UHFFFAOYSA-N
M.W :	178.11	Pubchem ID :	49871148
Synonyms :

Calculated chemistry of [ 827586-90-3 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.17
Num. rotatable bonds :	2
Num. H-bond acceptors :	5.0
Num. H-bond donors :	1.0
Molar Refractivity :	35.32
TPSA :	48.14 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.43 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.33
Log Po/w (XLOGP3) :	1.35
Log Po/w (WLOGP) :	2.83
Log Po/w (MLOGP) :	0.04
Log Po/w (SILICOS-IT) :	1.22
Consensus Log Po/w :	1.36

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.03
Solubility :	1.65 mg/ml ; 0.00927 mol/l
Class :	Soluble
Log S (Ali) :	-1.96
Solubility :	1.94 mg/ml ; 0.0109 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-2.29
Solubility :	0.911 mg/ml ; 0.00512 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.92

Safety of [ 827586-90-3 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P280-P305+P351+P338	UN#:	1759
Hazard Statements:	H302-H318	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 827586-90-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 827586-90-3 ]
Downstream synthetic route of [ 827586-90-3 ]

[ 827586-90-3 ] Synthesis Path-Upstream 1~1

1
[ 1221171-79-4 ]
[ 827586-90-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With ammonium formate In methanol at 55℃; for 16 h;	4-Amino-3-trifluoromethoxy pyridine (21); At 25 ⁰C, palladium (10percent on charcoal, 470 mg) was added with stirring to a solution of 4-amino-2-chloro-3-trifluoromethoxypyridine (20, 1.5 g, 7.0 mmol) and ammonium formate (880 mg, 14.0 mmol, 2 eq) in methanol (12 mL). The reaction mixture was stirred for 16 h at 55 ⁰C before being filtrated under suction and the solvent evaporated. The residue was partitioned between ethyl acetate (2^χ 20 mL) and water (30 mL). The combined organic layers were dried over sodium sulfate before being evaporated. The crude yellow oil was distilled under vacuum to afford pure 4-amino-3-trifluoromethoxy pyridine (21, 1.0 g, 5.6 mmol, 80percent) as a colorless oil; b.p 110-114 ⁰C / 14 mbar.¹H NMR (CDCl₃, 300 MHz): δ = 8.19 (s, 1 H), 8.05 (d, J= 5.5 Hz 1 H), 6.59 (d, J= 5.5Hz, 1 H), 4.41 (bs, 2 H). - ¹⁹F NMR (CDCl₃, 282 MHz): δ = -58.7. - ¹³C NMR (CD₃OD, 75 MHz): δ = 150.8, 148.5, 143.5, 132.9, 120.8 (q, J = 259 Hz), 110.4. - C₆H₅F₃N₂O (178): calcd. (percent) C 40.46, H 2.83, N 15.73; found C 40.28, H 2.74, N 15.94.

Reference： [1] Patent: WO2010/40461, 2010, A1, . Location in patent: Page/Page column 33-34
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066

[ 827586-90-3 ] Synthesis Path-Downstream 1~2

1
[ 1221171-79-4 ]
[ 827586-90-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With ammonium formate;palladium 10% on activated carbon; In methanol; at 55.0℃; for 16.0h;	4-Amino-3-trifluoromethoxy pyridine (21); At 25 0C, palladium (10% on charcoal, 470 mg) was added with stirring to a solution of 4-amino-2-chloro-3-trifluoromethoxypyridine (20, 1.5 g, 7.0 mmol) and ammonium formate (880 mg, 14.0 mmol, 2 eq) in methanol (12 mL). The reaction mixture was stirred for 16 h at 55 0C before being filtrated under suction and the solvent evaporated. The residue was partitioned between ethyl acetate (2chi 20 mL) and water (30 mL). The combined organic layers were dried over sodium sulfate before being evaporated. The crude yellow oil was distilled under vacuum to afford pure 4-amino-3-trifluoromethoxy pyridine (21, 1.0 g, 5.6 mmol, 80%) as a colorless oil; b.p 110-114 0C / 14 mbar.1H NMR (CDCl3, 300 MHz): delta = 8.19 (s, 1 H), 8.05 (d, J= 5.5 Hz 1 H), 6.59 (d, J= 5.5Hz, 1 H), 4.41 (bs, 2 H). - 19F NMR (CDCl3, 282 MHz): delta = -58.7. - 13C NMR (CD3OD, 75 MHz): delta = 150.8, 148.5, 143.5, 132.9, 120.8 (q, J = 259 Hz), 110.4. - C6H5F3N2O (178): calcd. (%) C 40.46, H 2.83, N 15.73; found C 40.28, H 2.74, N 15.94.

Reference： [1]Patent: WO2010/40461,2010,A1 .Location in patent: Page/Page column 33-34
[2]European Journal of Organic Chemistry,2010,p. 6043 - 6066

2
[ 827586-90-3 ]
3-(4-chloro-6-methylpyrimidin-2-yl)-1-[2,6-difluoro-4-(2-methoxyethoxy)benzyl]-1H-indazole [ No CAS ]
2-{1-[2,6-difluoro-4-(2-methoxyethoxy)benzyl]-1H-indazol-3-yl}-6-methyl-N-[3-(trifluoromethoxy)pyridin-4-yl]pyrimidin-4-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105.0℃;Inert atmosphere; Sealed tube;	64 mg of 3-(4-chloro-6-methylpyrim idin-2-yl)- 1 -(4-ethoxy-2,6-dif Iuorobenzyl)- 1 H-indazole1-13-2 (0.15 mmol, 1.0 eq.) were dissolved in 2 mL dioxane, and 17 mg pyridin-4-amine (0.18 mmol, 1.2 eq.), 3mg palladium(ll)acetate (0.01 mmol, 0.1 eq), 13mg (9,9-dimethyl- 9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.02 mmol, 0.15 eq) and 150 mg cesium carbonate (0.46 mmol, 3.0 eq.) were added. The reaction mixture was stirred at 105 C under argon atmosphere in a sealed vessel over night. All unsolved compounds werefiltered off and washed with dichloromethane / 2-propanole. The filtrate was concentrated under reduced pressure and purified by flash chromatography to provide 19 mg of the target compound in 92% purity: 26%.1H-NMR (400MHz, DMSO-d6): d [ppm]= 1.29 (t, 3H), 2.49 (5, 3H), 4.05 (q, 2H), 5.72 (5,2H), 6.32 - 6.50 (m, 1 H), 6.70 (5, 1 H), 6.76 - 6.88 (m, 2H), 7.30 (t, 1 H), 7.51 (td, 1 H), 7.89- 7.93 (m, 2H), 8.34 - 8.47 (m, 2H), 8.56 (d, 1 H), 9.99 (5, 1 H).

Reference： [1]Patent: WO2016/41925,2016,A1 .Location in patent: Page/Page column 359; 360; 384; 385

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 827586-90-3 ] {[proInfo.proName]}

Quality Control of [ 827586-90-3 ]

Related Doc. of [ 827586-90-3 ]

Product Details of [ 827586-90-3 ]

Calculated chemistry of [ 827586-90-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 827586-90-3 ]

Application In Synthesis of [ 827586-90-3 ]

[ 827586-90-3 ] Synthesis Path-Upstream 1~1

[ 827586-90-3 ] Synthesis Path-Downstream 1~2

Related Functional Groups of [ 827586-90-3 ]

Fluorinated Building Blocks

Ethers

Amines

Trifluoromethyls

Related Parent Nucleus of [ 827586-90-3 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 827586-90-3 ]

Related Parent Nucleus of
[ 827586-90-3 ]