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Chemical Structure| 83551-42-2 Chemical Structure| 83551-42-2

Structure of 83551-42-2

Chemical Structure| 83551-42-2

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Product Details of [ 83551-42-2 ]

CAS No. :83551-42-2
Formula : C10H8ClN3
M.W : 205.64
SMILES Code : CC1=CC(Cl)=NC(C2=CC=CN=C2)=N1
MDL No. :MFCD08443726

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Application In Synthesis of [ 83551-42-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 83551-42-2 ]

[ 83551-42-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 150-13-0 ]
  • [ 64090-19-3 ]
  • [ 83551-42-2 ]
  • N-(4-(4-fluorophenyl)piperazin-1-yl)-4-[6-methyl-2-(pyridin-3-yl)pyrimidin-4-yl]amino}benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
32% General procedure: A mixture of starting pyrimidine derivative (1.0 eq.), aminobenzoic acid (1.1 eq.) and twodrops of HCl (conc.) in aqueous ethanol (4 mL ethanol with 2 mL of water) was stirred atreflux overnight. The mixture was then evaporated to dryness and thoroughly dried in vacuoat 60 C overnight. Next day an obtained solid was dissolved in DMF (3 mL) and 2-fluoroethylamine hydrochloride (2.0 eq.), HBTU (1.0 eq) and triethylamine (8 eq.) wereadded stepwise.The reaction mixture was stirred at room temperature overnight. Then thereaction was quenched with water. The product was extracted with DCM and combinedorganic extracts were washed with saturated solution of NaHCO3, water, brine, dried overMgSO4, and concentrated in vacuo. A column chromatography (eluent EtOAc:methanol/7:1)of a residue afforded 0.21 g (39%) of product as a base which was further converted tohydrochloride salt by treatment with HCl.
 

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