Home Cart Sign in  
Chemical Structure| 848444-88-2 Chemical Structure| 848444-88-2

Structure of 848444-88-2

Chemical Structure| 848444-88-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 848444-88-2 ]

CAS No. :848444-88-2
Formula : C13H21NO5
M.W : 271.31
SMILES Code : O=C(N1C(C(OC)=O)C(C)(C)C(C1)=O)OC(C)(C)C
MDL No. :MFCD24470049
InChI Key :YBHLDAHDAOFWGW-UHFFFAOYSA-N
Pubchem ID :21982356

Safety of [ 848444-88-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 848444-88-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 848444-88-2 ]

[ 848444-88-2 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 848444-88-2 ]
  • [ 854375-56-7 ]
  • [ 478700-27-5 ]
YieldReaction ConditionsOperation in experiment
Bacilius lentus protease; In acetonitrile; for 16h;Enzymatic reaction; Example 6: Preparation of (2S)-4-oxo-3, 3-dimethyl-N-Boc-proline O BLP O O 10 %, pH 7. 2 H + Me-%, pH 7. 2 U-0 Y-Eo 0 H+ 30 C NBoc 98 % ee, Racemic ester 50 % conversion 10 mg of the racemic ester was suspended in 100 microliters of acetonitrile and was added to 900 mL of KPB buffer containing 10% Bacillus lentus protease (BLP). The reaction was stopped after 16 h, resulting in a 50% conversion and >98% ee of the acid product (2S)-4- oxo-3, 3-dimethyl-N-Boc-proline. Amano proleather FGF was another candidate, which was found to carry out this reaction with similar enatioselectivities and reactivity.
  • 2
  • [ 848444-88-2 ]
  • [ 1779-49-3 ]
  • [ 848444-89-3 ]
YieldReaction ConditionsOperation in experiment
46% Methyl triphenylphosphonium bromide (4.85 g, 13.6 MMOL) in THF at 0 C was added LHMDS (1 M solution in THF, 80 mL, 80 MMOL) SLOWLY. A light orange color was observed. This was maintained at 0 C for 20 min and then a solution of racemic ketone F3 (1.2 g, 4.24 MMOL) and THF (12 mL) was added. The solution remained orange in color. The ice-bath was removed and the solution was allowed to warm to 25 C for 3 h and then heated at 35 C for 1 h. This was then quenched with saturated aqueous NAHCO3 (40 mL) and EtOAc (400 mL). The layers were separated, the organic phase was washed with saturated aqueous NAHCO3 (3 x 100 mL) and dried (MGS04). The crude product was purified by SI02 column chromatography (1: 4-EtOAc: Hex) to give the desired product 0.52 G of 1 in 46% yield : H NMR (300 MHz, CDC13) 8 4.88 (m, 2H), 4.17 (m, 2H), 4.11 (s, 0.4H), 4.00 (s, 0.5H), 3.68 (s, 3H), 1.45 (s, 4H), 1.40 (s, 5H), 1.24 (s, 3H), 1.08 (s, 3H) ppm.
  • 3
  • [ 848444-88-2 ]
  • [ 478700-27-5 ]
  • 4
  • [ 848444-88-2 ]
  • [ 478698-32-7 ]
  • [ 854375-31-8 ]
  • 5
  • [ 848444-88-2 ]
  • [ 854375-33-0 ]
 

Historical Records

Technical Information

Categories