Home Cart Sign in  
Chemical Structure| 876746-33-7 Chemical Structure| 876746-33-7

Structure of 876746-33-7

Chemical Structure| 876746-33-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 876746-33-7 ]

CAS No. :876746-33-7
Formula : C10H11ClO4
M.W : 230.64
SMILES Code : O=C(OC)CCC1=CC=C(O)C(Cl)=C1O
MDL No. :MFCD11111602

Safety of [ 876746-33-7 ]

Application In Synthesis of [ 876746-33-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 876746-33-7 ]

[ 876746-33-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 117-21-5 ]
  • [ 876746-33-7 ]
  • C18H14Cl2O7 [ No CAS ]
  • [ 876746-04-2 ]
YieldReaction ConditionsOperation in experiment
With aluminum (III) chloride; In 1,2-dichloro-ethane; for 0.5h;Heating / reflux; To a solution of <strong>[117-21-5]3-chlorophthalic anhydride</strong> (3.7 g, 20 mmol) ((J. Org. Chem., 1987, 52,129-134) in 60 mL ofanhydrous 1,2-dichloroethane was added 6.6 g (50 mmol) of AlCls followed by 4.6 g (20mmol) of methyl 3-(3-chloro-2,4-dihydroxyphenyl)propanoate (WO 03/023357). Thereaction was heated at reflux for 30 min, cooled and concentrated. The resultant gelatinousmaterial was partitioned between cold 2 N HC1 (100 mL) and ethyl acetate (100 mL). Theorganic layer was washed with 1 N HC1, brine, dried over Na2SO4 and concentrated to affordan oily material (mixture of 6- and 2-chloroisomers). The oil was dissolved indichloromethane (~40 mL) and briefly sonicated (ultrasound bath) to initiate crystallization.The mixture was cooled (ice/water bath) and allowed to crystallize for 30 min (extendedcrystallization time will result in co-crystallization of undesired 2-chloro isomer). Thecrystals were collected by filtration washed with cold dichloromethane. Drying undervacuum afforded 4.01 g of desired 6-chloro isomer (32). *H NMR (DMSO-d6) 8 12.47 (br s,1H), 10.78 (br s, 1H), 8.06 (d, J=7.7 Hz ,1H), 7.89 (d, J-7.9 Hz, 1H), 7.71 (t, J=7.9 Hz, 1H),6.76 (s, 1H), 3.46 (s, 3H), 2.27 (m, 2H), 2.41 (t, J=6.6 Hz, 2H).
 

Historical Records

Technical Information

Categories