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[ CAS No. 98556-31-1 ] {[proInfo.proName]}

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Chemical Structure| 98556-31-1
Chemical Structure| 98556-31-1
Structure of 98556-31-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 98556-31-1 ]

CAS No. :98556-31-1 MDL No. :MFCD01862193
Formula : C8H4ClIN2 Boiling Point : -
Linear Structure Formula :- InChI Key :BDAIUOPDSRAOKI-UHFFFAOYSA-N
M.W : 290.49 Pubchem ID :11173809
Synonyms :

Calculated chemistry of [ 98556-31-1 ]

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 57.27
TPSA : 25.78 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.84 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.26
Log Po/w (XLOGP3) : 3.15
Log Po/w (WLOGP) : 2.89
Log Po/w (MLOGP) : 2.72
Log Po/w (SILICOS-IT) : 3.54
Consensus Log Po/w : 2.91

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -4.24
Solubility : 0.0166 mg/ml ; 0.0000573 mol/l
Class : Moderately soluble
Log S (Ali) : -3.36
Solubility : 0.126 mg/ml ; 0.000435 mol/l
Class : Soluble
Log S (SILICOS-IT) : -4.89
Solubility : 0.00377 mg/ml ; 0.000013 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 0.0
Synthetic accessibility : 1.8

Safety of [ 98556-31-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 98556-31-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 98556-31-1 ]
  • Downstream synthetic route of [ 98556-31-1 ]

[ 98556-31-1 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 16064-08-7 ]
  • [ 98556-31-1 ]
YieldReaction ConditionsOperation in experiment
99% With Vilsmeier reagent In 1,2-dichloro-ethane for 4.5 h; Heating / reflux Step B:
4-chloro-6-iodoquinazoline.
To a stirred solution of anhydrous dimethyl foramide (DMF) (3.20 ml) in 1,2-dichloroethane (DCE) (10 ml), cooled in an ice-water bath, is added dropwise under nitrogen a solution of oxalyl chloride (5.2 ml, 60 mmol) in DCE (25 ml).
A white precipitate forms during the addition.
After the end of addition the cold bath is removed and the reaction mixture is stirred at room temperature for 5 minutes. 6-Iodo-quinazolin-4-ol (5.0 g, 18 mmol) is added in portions via scoopula under nitrogen flow and the mixture is heated immediately to reflux.
Heating is continued for 4.5 hours, followed by cooling to room temperature.
The reaction mixture is poured into excess ice-water mixture (approximately 300 ml) and extracted with DCM (approximately 500 ml).
The aqueous layer is further extracted with DCM (2*50 ml).
The combined organic extracts are dried (Na2SO4) and concentrated under reduced pressure to yield 5.2 g (99percent) of desired product as a tan solid.
99% for 4.5 h; Reflux Step D: 4-chloro-6-iodoquinazoline (compound 1.4).[0105] To a solution of 6-Iodo-quinazolin-4-ol (5.0 g, 18 mmol) in thionyl chloride (10 mL) was added slowly DMF (0.5 mL) and the mixture is heated immediately to reflux. Heating is continued for 4.5 hours, followed by cooling to room temperature. The reaction mixture was then evaporated under reduced pressure to dryness. The residue was then redesolved ' in DCM (20 mL), and to it was added toluene (50 mL), and the mixture was then evaporated under reduced pressure to dryness. The procedure was repeated one more time to rid the product of thionyl chloride to yield 5.2 g (99percent) of desired product as a tan solid.
99% With oxalyl dichloride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 3 h; Compound 1 (784 mg, 2.88 mmol) was dissolved in 10 ml of tetrahydrofuran (THF), and oxalyl chloride (731 mg, 5.76 mmol) was added. Two droplets of DMF were immediately added as a reaction catalyst. And the mixture was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was completely concentrated to obtain Compound 2 (828 mg, 2.85 mmol, 99percent).
92.4% With thionyl chloride In N,N-dimethyl-formamide for 4 h; Reflux Compound 102 (14.4 g) was dissolved in thionyl chloride (50 ml)Adding 1 mL of the catalytic amount of anhydrous DMF,The reaction was refluxed for 4 hours.After completion of the reaction, excess thionyl chloride was distilled off under reduced pressure to give Compound 103. Yield 92.4percent.
88% With triethylamine; trichlorophosphate In toluene at 2 - 80℃; for 3.5 h; Inert atmosphere Solution of 6-iodo-quinazolin-4-one (0.54g, 2mmol) was added phosphorus oxychloride (0.37g, 2.4mmol), under nitrogen in dry toluene (2ml), triethylamine (0.24 g, 2.4mmol), leopard after the dropping was raised to 80 stirred 2.5h. The reaction solution was cooled to 2 stirred for 1h, and filtered. The filter cake was washed with acetone, washed with 1mol / L aqueous sodium hydroxide solution (in 3 ml of), washed with water and then with acetone. Vacuum dried to give a beige powder (0.5g, 88percent)
84%
Stage #1: With Chloro-oxo-acetic acid In 1,2-dichloro-ethane at 20 - 75℃; Heating / reflux
Stage #2: With sodium carbonate In water; 1,2-dichloro-ethane at 20℃;
Oxalyl chloride (11.8 g, 8.1 mL, 92.6 mmol, 2.0 equiv) was added to a suspension of 6-iodoquinazolin-4-ol (12.6 g, 46.2 mmol, 1.0 equiv), DMF (0.5 ml) and 1,2-dichloroethane (300 mL) resulting in the reaction temperature increasing from 21 to 25° C. The mixture was heated at about 75° C. overnight. TLC (50percent EtOAc/heptane) of an aliquot quenched with NaHCO3 showed the reaction to be incomplete. The mixture was cooled to room temperature, oxalyl chloride (2.0 mL, 0.5 equiv) added and the mixture refluxed for 7 hr. The clear dark brown solution was cooled to room temperature and poured very slowly into 10percent aqueous Na2CO3 solution (500 mL). The aqueous mixture was extracted with EtOAc (500 mL). Most of the aqueous phase was separated and the remaining mixture filtered to remove some insolubles at the interface. The phases of filtrate were separated, the organic phase washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The resulting solid was triturated with cold heptane (about 200 mL), filtered and dried to give 11.2 g (84percent) of 14 as a light brown solid that was used without further purification.
77% With thionyl chloride In N,N-dimethyl-formamide for 6 h; Reflux 4-chloro-6-iodoquinazoline
6-iodo-4(1H)-quinazolinone (10 g, 37 mmol) was weighed into a 250 mL flask.
Thionyl chloride (100 mL, 1.4 mmol) and DMF (0.5 mL, 6.5 mmol) were added to give a grey suspension.
The mixture was heated to reflux.
Heating was continued for 6 h and then the mixture was cooled on ice bath for 1 h.
A yellow solid precipitated and was collected by filtration to afford 8.6 g (77percent) of the title compound.
71% at 0 - 90℃; Step B: Preparation of 4-chloro-6-iodoquinazoline: To a cooled (0 °C) suspension of 6-iodoquinazolin-4-ol (107.6 g, 396 mmol) and DIEA (138 mL, 791 mmol) in dichloroethane (600 mL) was added POCl3 (44.25 mL, 475 mmol). After heating to 90 °C for 16 hours, the reaction mixture was cooled to room temperature and the crystals (73.8 g) collected by filtration. The filtrate was concentrated under reduced pressure and azeotroped twice with toluene. The solids (8.3 g) were triturated with isopropanol (450 mL) and cooled in an ice bath before collecting by filtration and drying under high vacuum. The two solids were combined to provide the product (82.1 g, 71percent) as white solid.

Reference: [1] Patent: US2005/101617, 2005, A1, . Location in patent: Page/Page column 6
[2] Patent: WO2011/2523, 2011, A1, . Location in patent: Page/Page column 43
[3] Patent: KR2017/15848, 2017, A, . Location in patent: Paragraph 0067; 0071; 0072
[4] Patent: CN106317026, 2017, A, . Location in patent: Paragraph 0075; 0076; 0077; 0078
[5] Patent: CN103772411, 2016, B, . Location in patent: Paragraph 0017; 0027; 0028
[6] Patent: US2008/51422, 2008, A1, . Location in patent: Page/Page column 13-14
[7] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5531 - 5538
[8] Patent: EP2744501, 2016, B1, . Location in patent: Paragraph 0156; 0157
[9] Patent: EP2090575, 2009, A1, . Location in patent: Page/Page column 61
[10] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[11] Patent: US2006/281772, 2006, A1, . Location in patent: Page/Page column 58-59
[12] Organic Process Research and Development, 2007, vol. 11, # 3, p. 406 - 413
[13] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 1, p. 27 - 37
[14] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1220 - 1227
[15] Patent: CN106986895, 2017, A, . Location in patent: Paragraph 0012; 0113
  • 2
  • [ 16064-08-7 ]
  • [ 98556-31-1 ]
YieldReaction ConditionsOperation in experiment
99% With oxalyl dichloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane for 4.5 h; Heating / reflux To a stirred solution of anhydrous dimethyl foramide (DMF) (3.20 ml) in 1,2- dichloroethane (DCE) (10 ml), cooled in an ice-water bath, is added dropwise under nitrogen a solution of oxalyl chloride (5.2 ml, 60 mmol) in DCE (25 ml). A white precipitate forms during the addition. After the end of addition the cold bath is removed and the reaction mixture is stirred at room temperature for 5 minutes. 6-IODO-QUINAZOLIN-4-OL (5.0 g, 18 mmol) is added in portions via scoopula under nitrogen flow and the mixture is heated immediately to reflux. Heating is continued for 4.5 hours, followed by cooling to room temperature. The reaction mixture is poured into excess ice-water mixture (approximately 300 ml) and extracted with DCM (approximately 500 ml). The aqueous layer is further extracted with DCM (2X50 ml). The combined organic extracts are dried (NA2SO4) and concentrated under reduced pressure to yield 5.2 g (99percent) of desired product as a tan solid.
92.7% With oxalyl dichloride; N,N-dimethyl-formamide In 1,2-dichloro-ethane for 1 h; Inert atmosphere; Reflux 3.2 ml of dry anhydrous DMF was added to 10 ml of dry DCE.At the same time, the reaction system was placed in a low-temperature cooling bath and stirred at 0°.Then 5.3 ml (60 mmol) of oxalyl chloride was added to 25 ml of dry anhydrous DCE to prepare a solution.The solution was slowly dropped into the appeal reaction system dropwise, kept stirring, and protected with nitrogen throughout.During the addition, a white solid precipitated in the reaction system and the reaction was removed after the dripping.Stir at room temperature for 5 minutes. Then compound 1 (5.0 g 18 mmol) was added to the reaction system.After the addition was complete, the reaction was transferred to an oil bath and the reaction was heated to reflux for 1 hour. Nitrogen protection was maintained throughout the reaction.After 1 hour, the reaction was removed from the oil bath and kept stirring to cool to room temperature.About 100 ml of ice water was added and the mixture was extracted with DCM (100 mL×3). The aqueous layer was separated and extracted with DCM. The combined organic phases were dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to obtain 4.36 g of a light gray solid (yield: 92.7). percent).
88% With triethylamine; trichlorophosphate In toluene at 80℃; for 2.5 h; Inert atmosphere To 6-iodo-quinazolin-4-one (0.54g, 2mmol) in dry toluene (2ml), was added a solution of phosphorus oxychloride (0.37g, 2.4mmol) under nitrogen, triethylamine (0.24 g, 2.4mmol) was added dropwise and the mixture was raised to 80 °C stirred for 2.5h. The reaction solution was cooled to 2 °C stirred for 1h and filtered. The filter cake was washed with acetone, washed with 1mol/L aqueous sodium hydroxide solution (in 3 ml) then washed with water and acetone and dried in vacuo to give a beige powder (0.5g, 88percent).
77% With thionyl chloride In N,N-dimethyl-formamideReflux 6-iodo-4(1H)-quinazolinone (10 g, 37 mmol)was weighed into a 250 mL flask. Thionyl chloride (100 mL, 1.4 mmol) and DMF (0.5mL, 6.5 mmol) were added to give a grey suspension. The mixture was heated to reflux.Heating was continued for 6 h and then the mixture was cooled on ice bath for 1 h. A yellow solid precipitated and was collected by filtration to afford 8.6 g (77percent) of the title compound.

Reference: [1] Patent: WO2004/46101, 2004, A2, . Location in patent: Page 19-20
[2] Patent: CN105085496, 2018, B, . Location in patent: Paragraph 0038; 0039
[3] Patent: CN103772371, 2016, B, . Location in patent: Paragraph 0054; 0055
[4] Patent: WO2013/25958, 2013, A1, . Location in patent: Page/Page column 55; 56
[5] Patent: WO2008/33747, 2008, A2, . Location in patent: Page/Page column 169
[6] Journal of the Indian Chemical Society, 1959, vol. 36, p. 787,789, 790
[7] Patent: WO2008/67144, 2008, A2, . Location in patent: Page/Page column 23
[8] Patent: WO2006/26313, 2006, A2, . Location in patent: Page/Page column 23
[9] Patent: WO2006/113649, 2006, A1, . Location in patent: Page/Page column 46
[10] Patent: US2011/281896, 2011, A1, . Location in patent: Page/Page column 7
[11] Patent: WO2013/116786, 2013, A1, . Location in patent: Page/Page column 18
[12] Patent: WO2014/134169, 2014, A1, . Location in patent: Page/Page column 5
[13] Patent: WO2005/120512, 2005, A2, . Location in patent: Page/Page column 23
[14] Patent: WO2005/120504, 2005, A2, . Location in patent: Page/Page column 30
[15] Patent: WO2004/43940, 2004, A1, . Location in patent: Page 82
  • 3
  • [ 16064-08-7 ]
  • [ 98556-31-1 ]
YieldReaction ConditionsOperation in experiment
99%
Stage #1: With triethylamine; trichlorophosphate In toluene at 20 - 75℃; for 2 h;
Stage #2: at 20℃; for 0.25 h;
In a 20 mL-volume glass vessel equipped with a stirrer, a thermometer and a reflux condenser were placed2.00 g (7.35 mmol) of 6-iodoquinazolin-4-one, 1.24 g (8.09 mmol) of phosphorus oxychloride, and 10 mL of toluene ina nitrogen atmosphere. While the mixture was stirred at room temperature, 0.82 g (8.09 mmol) of triethylamine wasslowly added. The resulting mixture was heated to 75C, and the reaction was carried out for 2 hours. After the reactionwas complete, the reaction mixture was cooled to room temperature, and 100 mL of methanol was added. The mixturewas stirred for 15 minutes at the same temperature, to give 6-iodo-4-methoxyquinazoline. Analysis of the reactionmixture by high performance liquid chromatography indicated that 2.11 g (reaction yield: 99percent) of 6-iodo-4-chloroquinazolinewas produced.
91%
Stage #1: With triethylamine; trichlorophosphate In toluene at 60 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
The procedures of Example IV-9 were repeated except for replacing acetone with methyl isopropyl ketone. There was produced 48.6 g (isolated yield: 91percent) of 6-iodo-4-chloroquinazoline.
90%
Stage #1: With triethylamine; trichlorophosphate In toluene at 20 - 75℃; for 2 h;
Stage #2: at 0℃; for 1 h;
In a 100 mL-volume glass vessel equipped with a stirrer, a thermometer and a reflux condenser were placed20.0 g (73.5 mmol) of 6-iodoquinazolin-4-one, 13.5 g (88.2 mmol) of phosphorus oxychloride, and 60 mL of toluene ina nitrogen atmosphere. While the mixture was stirred at room temperature, 8.92 g (88.2 mmol) of triethylamine wasslowly added. The resulting mixture was heated to 75C, and the reaction was carried out for 2 hours. After the reactionwas complete, the reaction mixture was cooled to 0C and stirred for one hour. Thus precipitated pale yellow crystallineproduct of 6-iodo-4-chloroquinazoline was collected by filtration. Subsequently, the crystalline product was placed in100 mL of aqueous sodium hydroxide (1 mol/L), and the aqueous mixture was stirred for 30 minutes at room temperature.The crystalline product was collected by filtration, washed with 120 mL of water, and dried under reduced pressure,to give 19.3 g (isolated yield: 90percent, purity 99.3percent in terms of area percentage determined by high performanceliquid chromatography) of 6-iodo-4-chloroquinazoline as a yellowish crystalline product.The analysis of 6-halogeno-4-chloroquinazoline in the reaction mixture was performed by the following procedures: After the reaction was complete, 6-halogeno-4-chloroquinazoline was reacted with methanol to give 6-halogeno-4-methoxyquinazoline quantitatively, which was then analyzed by high performance liquid chromatography. 6-Iodo-4-chloroquinazoline had the following physical properties.1H-NMR (CDCl3, d (ppm)): 7.80 (1H, d, J=7.8Hz), 8.20 (1H, dd, J=2.1, 9.0Hz), 8.65 (1H, d, J=2.1Hz), 9.06 (1H, s)CI-MS (m/e): 291 (M+1)
90%
Stage #1: With triethylamine; trichlorophosphate In toluene at 60 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
The procedures of Example IV-9 were repeated except for replacing acetone with chloroform. There was produced 48.1 g (isolated yield: 90percent) of 6-iodo-4-chloroquinazoline.
90%
Stage #1: With triethylamine; trichlorophosphate In toluene at 60 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
The procedures of Example IV-9 were repeated except for replacing acetone with acetonitrile. There was produced 48.1 g (isolated yield: 90percent) of 6-iodo-4-chloroquinazoline.
90%
Stage #1: With triethylamine; trichlorophosphate In chlorobenzene at 60 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
The procedures of Example IV-1 were repeated except for replacing toluene with chlorobenzene. There was produced 48.1 g (isolated yield: 90percent) of 6-iodo-4-chloroquinazoline.
89%
Stage #1: With triethylamine; trichlorophosphate In toluene at 20 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
In a 500 mL-volume glass vessel equipped with a stirrer, a thermometer and a reflux condenser were placed50.0 g (184 mmol) of 6-iodoquinazolin-4-one, 33.8 g (221 mmol) of phosphorus oxychloride, and 300 mL of toluene ina nitrogen atmosphere. While the mixture was stirred at room temperature, 22.3 g (221 mmol) of triethylamine wasslowly added. The resulting mixture was heated at 60C for 30 minutes and then heated at 75C for 2 hours, for carryingout reaction. After the reaction was complete, the reaction mixture was cooled to room temperature, and 50 mL ofacetone was added. The mixture was then cooled to 0C and stirred for 30 minutes. Thus precipitated pale yellowcrystalline product of 6-iodo-4-chloroquinazoline was collected by filtration. Subsequently, the crystalline product wasplaced in 200 mL of water, and 9 mL of aqueous sodium hydroxide (1 mol/L) was added. The aqueous mixture (pH 10- 11) was stirred for 30 minutes at room temperature. The crystalline product was collected by filtration, washed successivelywith 100 mL of acetone, 200 mL of water and 100 mL of acetone, and dried at 60C under reduced pressure,to give 47.4 g (isolated yield: 89percent, purity 99percent in terms of area percentage determined by high performance liquidchromatography) of 6-iodo-4-chloroquinazoline as a yellowish crystalline product.
89%
Stage #1: With triethylamine; trichlorophosphate In toluene at 60 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
The procedures of Example IV-9 were repeated except for replacing acetone with tetrahydrofuran. There was produced 47.6 g (isolated yield: 89percent) of 6-iodo-4-chloroquinazoline.
84%
Stage #1: With triethylamine; trichlorophosphate In toluene at 60 - 75℃; for 2.5 h;
Stage #2: at 0 - 20℃; for 0.5 h;
The procedures of Example IV-9 were repeated except for replacing acetone with methyl ethyl ketone. There was produced 44.9 g (isolated yield: 84percent) of 6-iodo-4-chloroquinazoline

Reference: [1] Patent: EP1481971, 2004, A1, . Location in patent: Page 10
[2] Patent: EP1481971, 2004, A1, . Location in patent: Page 11
[3] Patent: EP1481971, 2004, A1, . Location in patent: Page 9-10
[4] Patent: EP1481971, 2004, A1, . Location in patent: Page 11
[5] Patent: EP1481971, 2004, A1, . Location in patent: Page 11
[6] Patent: EP1481971, 2004, A1, . Location in patent: Page 11
[7] Patent: EP1481971, 2004, A1, . Location in patent: Page 10-11
[8] Patent: EP1481971, 2004, A1, . Location in patent: Page 11
[9] Patent: EP1481971, 2004, A1, . Location in patent: Page 11
[10] Patent: WO2009/63054, 2009, A1, . Location in patent: Page/Page column 69
[11] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8546 - 8555
  • 4
  • [ 5326-47-6 ]
  • [ 98556-31-1 ]
Reference: [1] Journal of the Indian Chemical Society, 1959, vol. 36, p. 787,789, 790
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8546 - 8555
[3] Patent: WO2013/116786, 2013, A1,
[4] Patent: WO2014/134169, 2014, A1,
[5] Organic Process Research and Development, 2007, vol. 11, # 3, p. 406 - 413
[6] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[7] Patent: CN103772411, 2016, B,
[8] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 1, p. 27 - 37
[9] Patent: CN103772371, 2016, B,
[10] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1220 - 1227
[11] Patent: CN106317026, 2017, A,
[12] Patent: WO2004/43940, 2004, A1,
  • 5
  • [ 79-37-8 ]
  • [ 98556-31-1 ]
Reference: [1] Patent: US6284764, 2001, B1,
  • 6
  • [ 79-37-8 ]
  • [ 68-12-2 ]
  • [ 98556-31-1 ]
Reference: [1] Patent: US6465449, 2002, B1,
  • 7
  • [ 77317-55-6 ]
  • [ 98556-31-1 ]
Reference: [1] Patent: KR2017/15848, 2017, A,
  • 8
  • [ 98556-31-1 ]
  • [ 383432-38-0 ]
Reference: [1] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[2] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[3] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[4] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[5] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
[6] Organic Process Research and Development, 2005, vol. 9, # 4, p. 440 - 450
  • 9
  • [ 537705-06-9 ]
  • [ 98556-31-1 ]
  • [ 383432-38-0 ]
Reference: [1] Organic Process Research and Development, 2007, vol. 11, # 3, p. 406 - 413
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