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Chemical Structure| 189114-61-2 Chemical Structure| 189114-61-2
Chemical Structure| 189114-61-2

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Synonyms: Silver triflimide

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Citations

Product Citations      Show More

Hintzsche, Samuel J. ; Vang, Zoua Pa ; Rivera Torres, Emanuel ; Podoski, Mykaela ; Clark, Joseph R. ;

Abstract: Selective deuterium installation into small molecules is becoming increasingly desirable not only for the elucidation of mechanistic pathways and studying biological processes but also because of deuterium's ability to favorably adjust the pharmacokinetic parameters of bioactive molecules. Fused bicyclic moieties, especially those containing heteroatoms, are prevalent in drug discovery and pharmaceuticals. Herein, we report a copper-catalyzed transfer hydrodeuteration of cyclic and heterocyclic alkenes, which enables the synthesis of chromans, quinolinones, and tetrahydronaphthalenes that are precisely deuterated at the benzylic position. We also demonstrate the ability to place one deuterium atom at the homobenzylic site of these scaffolds with high regioselectivity by swapping transfer reagents for their isotopic analogs. Furthermore, examples of chemoselective transfer hydrogenation and transfer deuteration are disclosed, allowing for the simultaneous incorporation of two vicinal hydrogen or deuterium atoms into a double bond.

Keywords: copper ; deuteration ; hydrodeuteration ; hydrogenation ; transition metal catalysis

Purchased from AmBeed: ; ; ; ; ; ;

Saavedra, Beatriz ; Bermejo-Lopez, Aitor ; Raeder, Majken ; Martin-Matute, Belen ;

Abstract: Unnatural amino acids are valuable building blocks with numerous applications. Here, we present a quant. technique for accessing mono-N-functionalized amino acids directly from unprotected substrates using alcs. as alkylating agents and an NHC-Ir(III) catalyst. We detail specific steps for catalyst preparation and application, as well as for catalyst recycling. The protocol excludes a few amino acids (L-cysteine, L-lysine, and L-arginine) and secondary alcs. For complete details on the use and execution of this protocol, please refer to Bermejo-Loṕez et al. (2022).1

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Alternative Products

Product Details of Silver bis(trifluoromethanesulfonyl)imide

CAS No. :189114-61-2
Formula : C2AgF6NO4S2
M.W : 388.01
SMILES Code : FC(F)(S(=O)([N-]1)=O[Ag+]O=S1(C(F)(F)F)=O)F
Synonyms :
Silver triflimide
MDL No. :MFCD08457644

Safety of Silver bis(trifluoromethanesulfonyl)imide

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1759
Packing Group:

Application In Synthesis of Silver bis(trifluoromethanesulfonyl)imide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 189114-61-2 ]

[ 189114-61-2 ] Synthesis Path-Downstream   1~3

  • 1
  • bis(η3-allyl-μ-chloropalladium(II)) [ No CAS ]
  • [ 1088-00-2 ]
  • [ 189114-61-2 ]
  • [ 948859-38-9 ]
  • 2
  • [ 174899-82-2 ]
  • [ 189114-61-2 ]
  • [ 1422393-56-3 ]
  • 3
  • [ 39769-09-0 ]
  • C8H4FN3 [ No CAS ]
  • [ 189114-61-2 ]
  • C2F6NO4S2(1-)*C33H20F5N2(1+) [ No CAS ]
 

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