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Chemical Structure| 359860-27-8 Chemical Structure| 359860-27-8
Chemical Structure| 359860-27-8

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Product Citations

Product Citations

Kofoed, Christian ; Erkalo, Girum ; Tay, Nicholas ES ; Ye, Xuanjia ; Lin, Yutong ; Muir, Tom W

Abstract: The surface landscapes of cells difer as a function of cell type and are frequently altered in disease contexts1–3. Exploiting such diferences is key to many therapeutic strategies and is the basis for developing diagnostic and basic-science tools. State-of-the-art strategies typically target single surface antigens, but each individual receptor rarely defnes the specifc cell type4,5. The development of programmable molecular systems that integrate multiple cell-surface features to convert on-target inputs to user-defned outputs is therefore highly desirable. Here we describe an autonomous decision-making device driven by proximity-gated protein trans-splicing that allows local generation of an active protein from two otherwise inactive polypeptide fragments. We show that this protein-actuator platform can perform convergent protein ligation on designated cell surfaces, allowing highly selective generation of active proteins, which can either remain physically associated with the cell surface on which they were manufactured or be released into the surrounding milieu. Because of its intrinsic modularity and tunability, we demonstrate that the technology is compatible with diferent types of input, targeting modality and functional output, allowing for the localized interrogation or manipulation of cellular systems.

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Product Details of Amine-PEG3-Biotin

CAS No. :359860-27-8
Formula : C18H34N4O5S
M.W : 418.55
SMILES Code : O=C(NCCOCCOCCOCCN)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
MDL No. :MFCD09952640
InChI Key :KIJSBKNJFAUJFV-ZOBUZTSGSA-N
Pubchem ID :50896259

Safety of Amine-PEG3-Biotin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H320-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of Amine-PEG3-Biotin

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

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