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Chemical Structure| 1951-25-3 Chemical Structure| 1951-25-3

Structure of Amiodarone
CAS No.: 1951-25-3

Chemical Structure| 1951-25-3

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Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.

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Product Citations

Product Citations

Pandey, Akanksha M ; Malwal, Satish R ; Valladares-Delgado, Mariana ; Labrador-Fagundez, Liesangerli ; Stella, Bruno G ; Diaz-Perez, Luis Jose , et al.

Abstract: We investigated the effects of the tuberculosis drug candidate SQ109 (8a) and of its analog MeSQ109 (8b) against Leishmania mexicana in promastigote and amastigote forms, as well as against host cell macrophages finding potent activity (1.7 nM) for MeSQ109 against the intracellular forms, as well as low toxicity (~61 µM) to host cells, resulting in a selectivity index of ~36,000. We then investigated the mechanism of action of MeSQ109 finding that it targeted parasite mitochondria, collapsing the proton motive force, as well as targeting acidocalcisomes, rapidly increasing the intracellular Ca2+ concentration. Using an E. coli inverted membrane vesicle assay, we investigated the pH gradient collapse for SQ109 and 17 analogs finding that there was a significant correlation (on average R=0.67, p~0.008) between pH gradient collapse and cell growth inhibition in Trypanosoma brucei, T. cruzi, L. donovani and Plasmodium falciparum. We also investigated pH gradient collapse with other anti-leishmanial agents: azoles, antimonials, benzofurans, amphotericin B and miltefosine. The enhanced activity against intracellular trypanosomatids is seen with Leishmania spp. grown in macrophages but not with Trypanosoma cruzi in epithelial cells and is proposed to be due in part to host-based killing, based on the recent observation that SQ109 is known to convert macrophages to a pro-inflammatory (M1) phenotype.

Keywords: Leishmaniasis ; Chagas disease ; Malaria ; SQ109 ; Acidocalcisomes ; PMF

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Product Details of Amiodarone

CAS No. :1951-25-3
Formula : C25H29I2NO3
M.W : 645.31
SMILES Code : CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3
MDL No. :MFCD00242801

Safety of Amiodarone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01082055 - Completed - United Kingdom ... More >> Univeristy of Dundee Dundee, United Kingdom, DD1 9SY Less <<
NCT03269383 Atrial Fibrillation Phase 4 Not yet recruiting December 2018 United States, Maine ... More >> Maine Medical Center Not yet recruiting Portland, Maine, United States, 04102 Contact: Janelle Richard, BA, CCRP    207-662-2862    richaj3@mmc.org    Principal Investigator: Chris Connors, MD Less <<
NCT02248753 Atrial Fibrillation Not Applicable Active, not recruiting October 2019 Netherlands ... More >> VU University Medical Center Amsterdam, Netherlands Amphia Hospital Breda, Netherlands Catharina Ziekenhuis Eindhoven, Netherlands Medisch Spectrum Twente Enschede, Netherlands University Medical Center Groningen Groningen, Netherlands Zuyderland Medical Center Heerlen, Netherlands Alrijne Hospital Leiderdorp, Netherlands Maastricht University Medical Center Maastricht, Netherlands St. Antonius Hospital Nieuwegein, Netherlands Franciscus Gasthuis Rotterdam, Netherlands Antonius Ziekenhuis Sneek, Netherlands HagaZiekenhuis The Hague, Netherlands St. Elisabeth - TweeSteden Hospital Tilburg, Netherlands Diakonessenhuis Utrecht, Netherlands VieCuri Medical Center Venlo, Netherlands Less <<
NCT02814903 - Unknown August 2017 France ... More >> Joachim ALEXANDRE Recruiting Caen, Basse Normandie, France, 14000 Contact: Mathieu CHEQUEL, MD    +33625342363    chequel-m@chu-caen.fr    Contact: Pierre OLLITRAULT, MD    +33624922671    ollitrault-p@chu-caen.fr Less <<
NCT03685149 Arrhythmogenic Right Ventricul... More >>ar Cardiomyopathy Less << Phase 2 Not yet recruiting August 2020 United States, New York ... More >> University of Rochester Medical Center Not yet recruiting Rochester, New York, United States, 14642 Contact: Spencer Rosero, MD    585-275-4775    spencer_rosero@urmc.rochester.edu    Contact: Laura Wing    585-273-4128    laura_wing@urmc.rochester.edu Less <<
NCT01856075 - Completed - Germany ... More >> Praxis fuer Kardiologie, Im Muehlenbach 2B Bonn, Germany, 53127 Less <<
NCT01742039 - Completed - United States, District of Col... More >>umbia George Washington University Hospital Washington DC, District of Columbia, United States, 20037 George Washington University Washington, District of Columbia, United States, 20037 Less <<
NCT02389218 Atrial Fibrillation Phase 4 Recruiting March 2020 Belgium ... More >> Brussels Heart Centre Recruiting Brussels, Belgium, 1000 Contact: Luc Jordaens, MD    +3228910961    ljordaens@clstjean.be    Contact: Peter Goethals, MD    +3228910961    pgoethals@clstjean.be    Saint Luc Recruiting Brussels, Belgium Contact: Jean-Benoit Le Polain De Waroux, MD, PhD    +3227642888    jblpdw@hotmail.com    Dept Cardiologie Recruiting Gent, Belgium, 9000 Contact: Frederic Van Heuverswyn, MD    +3293323459    Frederic.VanHeuverswyn@uzgent.be    Contact: Luc Jordaens, MD, Phd    +3293323459    l.jordaens@gmail.com Less <<
NCT02294955 Atrial Fibrillation ... More >> Quality of Life Less << Not Applicable Active, not recruiting September 2018 Sweden ... More >> Carina Blomström Lundqvist Uppsala, Sweden, S-75185 Less <<
NCT00920244 - Completed - Norway ... More >> St.Olavs Hospital, Department of Anesthesia Trondheim, Norway, 7014 Less <<
NCT01430806 ICD ICD SHOCK... More >>S DRONEDARONE Less << Not Applicable Unknown December 2015 -
NCT01411371 Atrial Fibrillation ... More >> Heart Failure Less << Not Applicable Unknown October 2011 United Kingdom ... More >> Barts & The London NHS Trust Recruiting London, UK, United Kingdom, EC1A 7BE Contact: Ross J Hunter, MRCP    442076018639    ross.hunter@bartsandthelondon.nhs.uk    Principal Investigator: Richard J Schilling, MD FRCP          Sub-Investigator: Ross J Hunter, MRCP Less <<
NCT01566344 Heart Diseases ... More >> Cardiac Arrhythmias Ventricular Premature Complexes Systolic Heart Failure Cardiomyopathies Less << Not Applicable Unknown December 2016 Netherlands ... More >> Maastricht University Medical Centre Recruiting Maastricht, Limburg, Netherlands, 6202 AZ Contact: Masih Mafi Rad, MD    +31-43-3871613    masih.mafirad@mumc.nl    Contact: Yuri Blaauw, MD, PhD    +31-43-3877095    yuri.blaauw@mumc.nl    Sub-Investigator: Masih Mafi Rad, MD Less <<
NCT01341353 Atrial Fibrillation Phase 4 Unknown December 2015 China, Hubei ... More >> Renmin Hospital of Wuhan University Recruiting Wuhan, Hubei, China Contact: Cong xin Huang, doctor    13907131546    huangcongxin@yahoo.com.cn    Principal Investigator: cong xin Huang, doctor Less <<
NCT01058837 - Unknown August 2011 United States, Washington ... More >> Seattle Institute for Cardiac Research Bellevue, Washington, United States, 98004-2206 Less <<
NCT00540787 Paroxysmal Atrial Fibrillation Phase 4 Completed - United States, Alabama ... More >> University of Alabama, Birmingham Birmingham, Alabama, United States, 35294 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Ohio Mid-Ohio Cardiology Columbus, Ohio, United States, 43214 France Hôpital Haut Lèvêque Pessac, Paris, France Hopital Lariboisiere Paris, France, 75010 Switzerland Hopital Cantonal de Geneve Geneva, Switzerland, 12111 Less <<
NCT00000531 Arrhythmia Ca... More >>rdiovascular Diseases Death, Sudden, Cardiac Heart Diseases Tachycardia, Ventricular Ventricular Fibrillation Less << Phase 3 Completed - -
NCT00121524 Cardiac Arrest Phase 2 Completed - Norway ... More >> Ulleval University Hospital Oslo, Norway, N-0407 Less <<
NCT01013688 Rheumatic Valve Disease ... More >> Atrial Fibrillation Less << Phase 3 Unknown May 2010 China ... More >> Fuwai cardiovascular disease hospital Recruiting Beijing, China, 100037 Contact: Wangxin , MD    86 10 15810210252    liuyedao21st@hotmail.com Less <<
NCT00721032 Ventricular Tachycardia Not Applicable Withdrawn(PI left the institut... More >>ion) Less << August 2015 United States, Oregon ... More >> Oregon Health & Science University Portland, Oregon, United States, 97239 Less <<
NCT01709682 Paroxysmal Atrial Fibrillation... More >> Failed First Radiofrequency Ablation Procedure Less << Phase 2 Completed - Russian Federation ... More >> State Research Institute of Circulation Pathology Novosibirsk, Russian Federation, 630055 Less <<
NCT01181414 Chronic Heart Failure ... More >> Cardiomyopathy, Dilated Atrial Fibrillation Less << Phase 4 Completed - Spain ... More >> Hospital Clinic de Barcelona Barcelona, Spain, 08036 Less <<
NCT03528616 - Not yet recruiting November 30, 2019 -
NCT01576042 - Terminated(Main objectives of ... More >>the study were met; consensus among investigators that continuing the study would not add new information beyond that already learned.) Less << - -
NCT01511263 Primary Amyloidosis of Light C... More >>hain Type Less << Phase 2 Terminated - Italy ... More >> Centro per lo Studio e la Cura delle Amiloidosi Sistemiche - Fondazione IRCCS Policlinico S.Matteo Pavia, Italy, 27100 Less <<
NCT01198275 Atrial Fibrillation Phase 3 Completed - Italy ... More >> Arrhytmias and Heart failure Unit-Spedali Civili Hospital Brescia, Italy, 25100 Less <<
NCT02303639 Myocardial Infarction ... More >> Ventricular Tachyarrhythmia Less << Phase 4 Unknown June 2018 Finland ... More >> Central Finland Central Hospital Recruiting Jyväskylä, Finland Heart Center Tampere University Hospital Recruiting Tampere, Finland Contact: Heikki Mäkynen, MD Less <<
NCT01576042 Ventricular Tachycardia Not Applicable Terminated(Main objectives of ... More >>the study were met; consensus among investigators that continuing the study would not add new information beyond that already learned.) Less << - United States, Maryland ... More >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania Penn State Milton S. Hershey Medical Center Hershey, Pennsylvania, United States, 17033 University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15237 Less <<
NCT01798277 Ventricular Tachycardia ... More >> Coronary Artery Disease Less << Phase 3 Withdrawn(Low Enrolment) December 2015 -
NCT02830360 Ventricular Tachycardia (VT) Phase 4 Recruiting October 2022 Canada, Nova Scotia ... More >> Nova Scotia Health Authority Recruiting Halifax, Nova Scotia, Canada, B3H 3A7 Contact: Karen Giddens    902 473 2758    karen.giddens@nshealth.ca    Principal Investigator: John L Sapp, MD FRCPC Less <<
NCT00000609 Arrhythmia Ca... More >>rdiovascular Diseases Death, Sudden, Cardiac Heart Diseases Heart Failure, Congestive Heart Failure Less << Phase 3 Completed - -
NCT01198275 - Completed - -
NCT03734562 Monomorphic Ventricular Tachyc... More >>ardia Less << Not Applicable Completed - Spain ... More >> Hospital General UNiversitario Gregorio Marañon Madrid, Spain, 28009 Less <<
NCT01850277 Atrial Fibrillation ... More >> Heart Failure Less << Phase 4 Unknown March 2017 Poland ... More >> Institute of Cardiology, II Dept. of Coronary Heart Disease Recruiting Warsaw, Poland, 02-637 Contact: Jan B Ciszewski, MD    223434050 ext +48    jciszewski@ikard.pl    Principal Investigator: Jan B Ciszewski, MD Less <<
NCT02132767 - Completed - -
NCT00257959 Ventricular Tachycardia Phase 4 Completed - Canada, Ontario ... More >> McMaster University Hamilton, Ontario, Canada Less <<
NCT02132767 Postoperative Atrial Fibrillat... More >>ion Less << Phase 3 Completed - -
NCT00233441 Atrial Fibrillation ... More >> Atrial Flutter Less << Phase 2 Phase 3 Completed - -
NCT02114528 Ventricular Tachycardia ... More >> Ventricular Arrhythmia Less << Phase 4 Terminated(Low recruitment. Pi... More >>lot trial.) Less << - Canada, Ontario ... More >> University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Less <<
NCT00272636 Atrial Fibrillation Not Applicable Completed - United States, Michigan ... More >> University of Michigan Health System Ann Arbor, Michigan, United States, 48109 Italy San Raffaele Hospital Milan, Italy Less <<
NCT00000464 Arrhythmia Ca... More >>rdiovascular Diseases Heart Arrest Heart Diseases Myocardial Infarction Ventricular Fibrillation Less << Phase 3 Completed - -
NCT01955759 Patients With Coronary Artery ... More >>Disease Scheduled for by Pass Surgery Less << Early Phase 1 Unknown February 2015 Bosnia and Herzegovina ... More >> Heart Center BH Not yet recruiting Tuzla, TK, Bosnia and Herzegovina, 75000 Contact: Enes Osmanović    +387 66 725 744    osmanovic@bih.net.ba Less <<
NCT01140581 Atrial Fibrillation Phase 4 Completed - -
NCT00905853 Recurrent Ventricular Tachycar... More >>dia Less << Phase 4 Completed - Canada, Nova Scotia ... More >> QEII Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 3A7 Less <<
NCT02145546 Atrial Fibrillation Phase 4 Unknown May 2017 China, Shanghai ... More >> Xinhua Hospital, Shanghai Jiao Tong University School of Medicne Not yet recruiting Shanghai, Shanghai, China, 200092 Principal Investigator: Yi-Gang Li, MD Less <<
NCT00287209 Atrial Fibrillation|Coronary A... More >>rtery Bypass Grafting Less << PHASE4 COMPLETED 2025-08-05 Department of Cardiothoracic a... More >>nd Vascular Surgery & Institute of Clinical Medicine, Skejby Sygehus, Aarhus University Hospital, Aarhus N, 8200, Denmark Less <<
NCT01229254 Atrial Fibrillation ... More >> Atrial Flutter Less << Phase 2 Completed - -
NCT01229254 - Completed - -
NCT03228823 Ventricular Premature Beats, C... More >>ontractions, or Systoles Cardiomyopathies Less << Phase 4 Not yet recruiting August 31, 2020 United States, California ... More >> University of California, San Francisco Not yet recruiting San Francisco, California, United States, 94143 Contact: Edward Gerstenfeld, M.D.    415-476-5706    edward.gerstenfeld@ucsf.edu    Principal Investigator: Edward Gerstenfeld, M.D.          Principal Investigator: Teresa DeMarco, M.D.          United States, Virginia McGuire VA Medical Center Not yet recruiting Richmond, Virginia, United States, 23249 Contact: Jose F Huizar, M.D.    804-675-5466    jose.huizar2@va.gov    Contact: Donna Sargent, R.N..    804-675-5466    donna.sargent@va.gov    Principal Investigator: Jose F Huizar, M.D.          Sub-Investigator: Karoly Kaszala, M.D., Ph.D.          Sub-Investigator: Alex Y Tan, M.D.          Virginia Commonwealth University Not yet recruiting Richmond, Virginia, United States, 23298 Contact: Kenneth A Ellenbogen, M.D.    804-628-0147    kenneth.Ellenbogen@vcuhealth.org    Principal Investigator: Kenneth A Ellenbogen, M.D.          Principal Investigator: Adam Sima, Ph.D.          Canada, Alberta Libin Cardiovascular Institute, University of Calgary Not yet recruiting Calgary, Alberta, Canada, T2N 2T9 Contact: Carlos A Morillo, M.D.    403-944-2670    carlos.morillo@ucalgary.ca    Principal Investigator: Carlos A Morillo, M.D. Less <<
NCT00420953 Healthy Phase 1 Completed - Canada, Quebec ... More >> Anapharm Montreal, Quebec, Canada Less <<
NCT03715556 Sepsis Septic... More >> Shock Atrial Fibrillation Ventricular Fibrillation Atrial Fibrillation Rapid Less << Phase 3 Not yet recruiting December 1, 2021 Brazil ... More >> Instituto do Coração - HMFMUSP São Paulo, Brazil, 05403000 Less <<
NCT01558830 Chronic Stable Angina ... More >> Coronary Artery Disease Atrial Fibrillation Ventricular Tachycardia Less << Phase 4 Unknown July 2013 United States, Nevada ... More >> Cardiovascular Consultants of Nevada Recruiting Henderson, Nevada, United States, 89052 Cardiovascular Consultants of Nevada Recruiting Las Vegas, Nevada, United States, 89144 Cardiovascular Consultants of Nevada Recruiting Las Vegas, Nevada, United States, 89196 Less <<
NCT01461733 Atrial Fibrillation Phase 4 Completed - -
NCT01461733 - Completed - -
NCT01199081 Atrial Fibrillation Phase 4 Completed - -
NCT00007605 Atrial Fibrillation ... More >> Cerebrovascular Accident Death, Sudden Less << Phase 3 Completed - -
NCT00127712 Atrial Fibrillation PHASE4 COMPLETED 2025-02-08 Indiana University, Indianapol... More >>is, Indiana, 46202, United States Less <<
NCT00953212 Atrial Fibrillation ... More >> Atrial Flutter Less << Phase 3 Completed - United States, Maine ... More >> Maine Medical Center Portland, Maine, United States, 04102 Less <<
NCT00420017 - Completed - -
NCT00420017 Atrial Fibrillation ... More >> Esophagectomy Less << Phase 4 Completed - United States, Indiana ... More >> Indiana University Hospital Indianapolis, Indiana, United States, 46202 Less <<
NCT00127712 Atrial Fibrillation PHASE4 COMPLETED 2025-02-08 Indiana University, Indianapol... More >>is, Indiana, 46202, United States Less <<
NCT03244748 - Recruiting March 1, 2018 Turkey ... More >> Turkiye Yuksek Ihtisas Training and Research Hospital Recruiting Ankara, Turkey, 06590 Contact: Firat Ozcan, Ass. Prof, MD    5327854000    drfozcan@gmail.com Less <<
NCT01649544 Mitral Valvulopathy ... More >> Atrial Fibrillation Less << Not Applicable Terminated(End of commercializ... More >>ation of the medical device) Less << - France ... More >> CHU de Grenoble Grenoble, France Hospices Civiles de Lyon Lyon, France CHU de Montpellier Montpellier, France CHU de Rennes Rennes, France CHU de Saint-Etienne Saint-etienne, France Less <<
NCT03029169 Supraventricular Arrhythmia ... More >> Septic Shock Less << Phase 4 Recruiting October 2020 Czechia ... More >> Dept. Anaesthesia and Intensive Care, 3rd Medical Faculty, Charles University Recruiting Prague 10, Czechia, 100 34 Contact: Petr Waldauf, MD    +420267163410    petrwaldauf@gmail.com    Dept of Anaesthesia and Intensive Care, General University Hospital, 1st Medical Faculty, Charles University Recruiting Prague 2, Czechia, 128 08 Contact: Martin Balik, A/Prof    +420224963366    martin.balik@vfn.cz    Principal Investigator: Martin Balik, MD, PhD Less <<
NCT00993382 Arrhythmia Prophylaxis ... More >> Ventricular Arrhythmia Less << Phase 2 Completed - -
NCT00383799 Ventricular Tachycardia ... More >> Wide QRS Tachycardia Less << Phase 4 Terminated(Steering Committee ... More >>decision after inclusion of 74 patients after 6 years and very slow inclusion rate) Less << - Spain ... More >> Hospital El Escorial El Escorial, Madrid, Spain Hospital Universitario de Getafe Getafe, Madrid, Spain Hospital Santa María del Rosell Cartagena, Murcia, Spain Fundación Hospitalaria de Cieza Cieza, Murcia, Spain Hospital Los Arcos San Javier, Murcia, Spain Hospital General Alicante, Spain Hospital Clinic Barcelona, Spain Hospital Vall d'Hebron Barcelona, Spain Hospital de Basurto Bilbao, Spain Hospital San Cecilio Granada, Spain Hospital Virgen de las Nieves Granada, Spain Hospital General Universitario Gregorio Marañón Madrid, Spain, 28007 Hospital 12 de Octubre Madrid, Spain Hospital Clínico San Carlos Madrid, Spain Hospital de La Princesa Madrid, Spain Hospital de Móstoles Madrid, Spain Hospital General Universitario La Paz Madrid, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Carlos Haya Malaga, Spain Hospital Virgen de la Arrixaca Murcia, Spain Hospital Clínico Virgen de la Victoria Málaga, Spain Hospital de Son Dureta Palma de Mallorca, Spain Hospital de Son Llatzer Palma de Mallorca, Spain Hospital de Donostia San Sebastián, Spain Hospital de Valme Sevilla, Spain Hospital Universitario Virgen del Rocío Sevilla, Spain Hospital Virgen de la Salud Toledo, Spain Hopital Clínico Universitario Valencia, Spain Hospital Río Hortega Valladolid, Spain Less <<
NCT00251706 Atrial Fibrillation Phase 3 Completed - Canada, Alberta ... More >> Libin Cardiovascular Institute / University of Calgary Calgary, Alberta, Canada, T2N 2T9 Less <<
NCT00826826 Atrial Fibrillation Not Applicable Completed - Denmark ... More >> Rigshospitalet Copenhagen, Denmark, 2100 Gentofte University Hospital Hellerup, Denmark, 2900 Less <<
NCT00953212 - Completed - -
NCT02301390 Ventricular Tachycardia Not Applicable Terminated(could not meet enro... More >>llment goal) Less << - India ... More >> CARE Institute of Medical Science Ahmedabad, India CARE Hospital Hyderabad, India Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry, India Less <<
NCT00739193 Blood Pressure Phase 2 Withdrawn December 2008 -
NCT00654290 Atrial Fibrillation Not Applicable Completed - Iran, Islamic Republic of ... More >> Shiraz University of Medical Sciences/Cardiac Surgery and Cardiology Ward/Namazi and Shahid Faghihi Hospital Shiraz, Fars, Iran, Islamic Republic of, 71345 Less <<
NCT00392431 Persistant Atrial Fibrillation Not Applicable Completed - Netherlands ... More >> University Medical Center Groningen Groningen, Netherlands, 9700RB Less <<
NCT02171026 Healthy Phase 1 Completed - -
NCT02715687 Atrial Fibrillation Phase 3 Unknown December 2018 -
NCT00729911 Heart Failure Phase 4 Active, not recruiting December 2018 United States, Texas ... More >> Texas Cardiac Arrhythmia Research Foundation Austin, Texas, United States, 78758 Less <<
NCT00489736 Atrial Fibrillation Phase 3 Completed - -
NCT00784316 Atrial Fibrillation ... More >> Cardiac Surgery Less << Phase 4 Completed - Finland ... More >> Halonen jari Kuopio, Finland, FIN- 70211 Less <<
NCT00587483 - Completed - -
NCT01480336 Arrhythmia Not Applicable Completed - United States, Connecticut ... More >> Hartford Hospital Hartford, Connecticut, United States, 06102 Less <<
NCT00587483 Other Intraoperative Cardiac F... More >>unctional Disturbances During Cardiac Surgery Less << Not Applicable Completed - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00489736 - Completed - -
NCT00668759 Atrial Fibrillation Phase 3 Completed - -
NCT01401647 Cardiac Arrest Phase 3 Completed - United States, Alabama ... More >> Alabama Resuscitation Center Birmingham, Alabama, United States, 35294 United States, California UCSD-San Diego Resuscitation Center San Diego, California, United States, 92103 United States, Oregon Portland Resuscitation Outcomes Consortium, Oregon Health & Sciences University Portland, Oregon, United States, 97239 United States, Pennsylvania The Pittsburgh Resuscitation Network, University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15261 United States, Texas Dallas Center for Resuscitation Research, University of Texas Southwestern Medical Center Dallas, Texas, United States, 75390 United States, Washington Seattle-King County Center for Resuscitation Research, University of Washington Seattle, Washington, United States, 98195 United States, Wisconsin Milwaukee Resuscitation Network, Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Canada, Ontario University of Ottawa/University of British Columbia Collaborative RCC, Ottawa Health Research Ottawa, Ontario, Canada Toronto Regional Resuscitation Research Out-of-Hospital Network, University of Toronto Toronto, Ontario, Canada Less <<
NCT01401647 - Completed - -
NCT00300495 Atrial Fibrillation ... More >> Lung Cancer Less << Phase 3 Terminated(Unable to accrual t... More >>otal number of participants during study period.) Less << - United States, Massachusetts ... More >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Less <<
NCT01627106 Atrial Fibrillation Phase 4 Withdrawn March 2016 -
NCT01416935 Atrial Fibrillation Not Applicable Unknown July 2016 United States, Virginia ... More >> Inova Fairfax Hospital Falls Church, Virginia, United States, 22042 Less <<
NCT00313443 Arrhythmia At... More >>rial Fibrillation Atrial Flutter Less << Phase 4 Completed - France ... More >> Hopital Lariboisiere, Internal Medicine "A" and Cardiology Services Paris, France, 75010 Less <<
NCT00300495 - Terminated(Unable to accrual t... More >>otal number of participants during study period.) Less << - -
NCT00313443 - Completed - -
NCT03720210 Amiodarone-Induced Thyrotoxico... More >>sis Less << Not Applicable Recruiting July 2020 United States, Minnesota ... More >> Mayo Clinic in Rochester Recruiting Rochester, Minnesota, United States, 55905 Contact: Marius Stan, MD    507-284-2463    Stan.Marius@mayo.edu    Contact: Vishakantha (Vishu) Murthy, PhD    507-255-8112    Murthy.Vishakantha@mayo.edu Less <<
NCT01276093 Atrial Fibrillation Not Applicable Terminated(DSMB recommendation... More >>; enrollment too slow) Less << March 2016 Netherlands ... More >> Elkerliek Hospital Helmond, Noord Brabant, Netherlands Maxima Medical Center Veldhoven, Noord Brabant, Netherlands, 5504DB Haga Hospital Den Haag, Zuid Holland, Netherlands, 2545 CH Onze Lieve Vrouwen Gasthuis Amsterdam, Netherlands, 1091 AC Catharina Ziekenhuis Eindhoven, Netherlands, 5623 EJ Medisch Spectrum Twente Enschede, Netherlands, 7513 ER Less <<
NCT01722942 Chagas Cardiomyopathy ... More >> Non-sustained Ventricular Tachycardia At Least 10 Points in Rassi Risk Score for Death Less << Not Applicable Not yet recruiting October 2019 Brazil ... More >> Hospital Ana Nery Not yet recruiting Salvador, BA, Brazil Contact: Luiz P Magalhães, MD       luizpmagalhaes@uol.com.br    Contact: Alexandro A Fagundes, MD       alexfagundes@cardiol.br    Principal Investigator: Luiz P Magalhães, MD          Sub-Investigator: Alexsandro A Fagundes, MD          Santa Casa de Salvador Not yet recruiting Salvador, BA, Brazil Contact: Ricardo E Pereira, MD       rickeloy@terra.com.br    Principal Investigator: Ricardo E Pereira, MD          Hospital de Messejana Not yet recruiting Fortaleza, CE, Brazil Contact: João D Souza Neto, MD       jdsneto@cardiol.br    Contact: Stela MV Sampaio, MD       stelavsampaio@terra.com.br    Principal Investigator: João D Souza Neto, MD          Sub-Investigator: Stela MV Sampaio, MD          Hospital Universitário Walter Cantideo Not yet recruiting Fortaleza, CE, Brazil Contact: Francisca TM Pereira, MD       tatianap@baydenet.com.br    Contact: Eduardo A Rocha, MD       eduardoa@cardiol.br    Principal Investigator: Francisca TM Pereira, MD          Sub-Investigator: Eduardo A Rocha, MD          Sub-Investigator: Marcelo P Monteiro, MD          Hospital de Base Not yet recruiting Brasilia, DF, Brazil Contact: Ayrton K Peres, MD, PhD       ayrton.ritmocardio@gmail.com    Contact: Tamer N Seixas, MD, PhD       tamersn@cardiol.br    Principal Investigator: Ayrton K Peres, MD, PhD          Sub-Investigator: Thamer N Seixas, MD, PhD          Sub-Investigator: Edna MM Oliveira, MD          Sub-Investigator: Marcus VN Santos, MD          Sub-Investigator: Romeu Mello Neto, MD          Instituto de Cardiologia do Distrito Federal Not yet recruiting Brasilia, DF, Brazil Contact: José M Baggio Jr, MD       jmbaggio@cardiol.br    Principal Investigator: José M Baggio Jr, MD          Sub-Investigator: Renato Bueno, MD          Anis Rassi Hospital Not yet recruiting Goiania, GO, Brazil Contact: Anis Rassi Jr, MD, PhD       arassijr@terra.com.br    Principal Investigator: Anis Rassi Jr, MD, PhD          Hospital das Clínicas de Goiania Not yet recruiting Goiania, GO, Brazil Contact: Salvador Rassi, MD, PhD       srassi@cardiol.br    Principal Investigator: Salvador Rassi, MD, PhD          Santa Casa de Goiania Not yet recruiting Goiania, GO, Brazil Contact: Sérgio Rassi, MD       sgrassi@cultura.com.br    Contact: Antônio MC Lima, MD       antoniomalanc@gmail.com    Sub-Investigator: Antonio MC Lima, MD          Principal Investigator: Sérgio Rassi, MD          Hospital Felício Rocho Not yet recruiting Belo Horizonte, MG, Brazil Contact: Maria CV Moreira, MD, PhD       moreiram@cardiol.br    Contact: Thiago R Rodrigues, MD       thiagorrodrigues@oi.com.br    Sub-Investigator: Thiago R Rodrigues, MD          Principal Investigator: Maria CV Moreira, MD, PhD          Hospital das Clínicas Samuel Libânio Not yet recruiting Pouso Alegre, MG, Brazil Contact: Ricardo A Teixeira, MD, PhD       ricardo.alkmim@hotmail.com    Principal Investigator: Ricardo A Teixeira, MD, PHD          Hospital Escola da Universidade Federal do Triângulo Mineiro Not yet recruiting Uberaba, MG, Brazil Contact: Celso S Melo, MD       celsosalgado@uol.com.br    Principal Investigator: Celso S Melo, MD          Hospital Geral Universitário Not yet recruiting Cuiabá, MT, Brazil Contact: Júlio C Oliveira, MD, PhD       juliocesar@atriumcardiologia.com.br    Principal Investigator: Júlio C Oliveira, MD, PhD          Hospital Universitário Procape Not yet recruiting Recife, PE, Brazil Contact: Dário Sobral Filho, MD, PhD       dsobral@uol.com.br    Contact: Abelardo G Escarião, MD       escariao@hotmail.com    Principal Investigator: Dário C Sobral Filho, MD, PhD          Sub-Investigator: Adelardo G Escariao, MD          Sub-Investigator: Antonio M Nascimento, MD          Sub-Investigator: Wilson A Oliveira Jr, MD          Hospital Santa Casa de Misericórdia de Curitiba Not yet recruiting Curitiba, PR, Brazil Contact: Gerson Lemke, MD          Contact: José CM Jorge, MD, PhD       mourajorge@terra.com.br    Principal Investigator: Gerson Lemke, MD          Sub-Investigator: José CM Jorge, MD, PhD          Hospital do Coração de Natal Not yet recruiting Natal, RN, Brazil Contact: Álvaro RB Costa, MD       alvaro@digi.com.br    Principal Investigator: Álvaro RB Costa, MD          Hospital Universitário Onofre Lopes - UFRGN Not yet recruiting Natal, RN, Brazil Contact: Nestor R Oliveira Neto, MD       nestor_rn@superig.com.br    Principal Investigator: Nestor R Oliveira Neto, MD          Hospital das Clínicas da UNICAMP Not yet recruiting Campinas, SP, Brazil Contact: Márcio JO Figueiredo, MD, PhD       mjofig@gmail.com    Principal Investigator: Márcio JO Figueiredo, MD, PhD          Sub-Investigator: Otávio R Coelho, MD          Hospital e Maternidade Celso Pierro - PUCC Not yet recruiting Campinas, SP, Brazil Contact: José MN Lima, MD, PhD       jmarcolima@gmail.com    Contact: Fernando M Porto, MD       ritmocamp@hotmail.com    Principal Investigator: José MN Lima, MD, PhD          Sub-Investigator: Fernando M Porto, MD          Sub-Investigator: Halim Cury Filho, MD          Hospital do Coração da Fundação de Misericórdia de Franca Not yet recruiting Franca, SP, Brazil Contact: Rodrigo T Silva, MD, PhD       rotasil@ig.com.br    Principal Investigator: Rodrigo T Silva, MD, PhD          Santa Casa de Ribeirão Preto Not yet recruiting Ribeirão Preto, SP, Brazil, 14080-000 Contact: Antonio Vitor Moraes Jr, MD, PhD    +55 16 97920407    avitor@terra.com.br    Principal Investigator: Antonio Vitor Moraes Jr, MD, PhD          HC - FMUSP / Ribeirão Preto Not yet recruiting Ribeirão Preto, SP, Brazil Contact: José A Marin-Neto, MD, Full Prof.       marin_neto@yahoo.com    Contact: Marcelo G Leal, MD, PhD       mgleal@cardiol.br    Principal Investigator: José A Marin-Neto, MD, FullProf          Principal Investigator: Marcelo G Leal, MD, PhD          Sub-Investigator: Elerson Arfelli, MD          Sub-Investigator: Andre Schmidt, MD, PhD          Sub-Investigator: Adilson Escorzonic, MD          Sub-Investigator: Jairo R Silva Jr, MD          Sub-Investigator: Henrique T Moreira, MD          Sub-Investigator: Maria LRC Pavao, MD          Instituto de Moléstias Cardiovasculares Not yet recruiting São José do Rio Preto, SP, Brazil Contact: Adalberto Lorga Filho, MD, PhD       lorgafilho@terra.com.br    Contact: Oswaldo T Greco, MD       oswaldogreco@terra.com.br    Principal Investigator: Adalberto Lorga Filho, MD, PhD          Sub-Investigator: Rinaldo Santos, MD          Heart Institute (InCor) - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Not yet recruiting São Paulo, SP, Brazil, 05403000 Contact: Martino Martinelli, MD, PhD    55 11 26615515    martino@incor.usp.br    Contact: Sergio F Siqueira, Eng, MsC    55 11 26615514    siqueira@incor.usp.br    Sub-Investigator: Sérgio F Siqueira, Eng, MsC          Sub-Investigator: Giselle L Peixoto, MD          Sub-Investigator: Roberto Costa, MD, PhD          Sub-Investigator: Maurício I Scanavacca, MD, PhD          Sub-Investigator: Antonio CP Barreto, MD, PhD          Sub-Investigator: Barbara M Ianni, MD, PhD          Sub-Investigator: Denise T Hachul, MD, PhD          Sub-Investigator: Edmar Bocchi, MD, PhD          Sub-Investigator: Fernando Bacal, MD, PhD          Sub-Investigator: Francisco CC Darriex, MD, PhD          Sub-Investigator: Germano Souza, MD, PhD          Sub-Investigator: Silvana AD Nishioka, MD, PhD          Sub-Investigator: Anisio AA Pedrosa, MD, PhD          Sub-Investigator: Ricardo A Teixeira, MD, PhD          Principal Investigator: Jose Antonio Marin-Neto, Prof          Principal Investigator: Anis Rassi Jr, MD, PhD          Beneficiência Portuguesa Not yet recruiting São Paulo, SP, Brazil Contact: Silas S Galvão Filho, MD       sdsantos@uol.com.br    Contact: José TM Vasconcelos, MD, PhD       tarr@terra.com.br    Principal Investigator: Silas S Galvão Filho          Sub-Investigator: José TM Vasconcelos, MD, PhD          Escola Paulista de Medicina Not yet recruiting São Paulo, SP, Brazil Contact: Angelo Paola, MD, Full Prof       depaola@uol.com.br    Contact: Guilherme Fenelon, MD, PhD       guilhermefenelon@uol.com.br    Principal Investigator: Angelo Paola, MD, Full Prof          Sub-Investigator: Guilherme Fenelon, MD, PhD          Instituto Dante Pazzanese de Cardiologia Not yet recruiting São Paulo, SP, Brazil Contact: Juan C Pachón, MD       juanpachon@gmail.com    Principal Investigator: Juan C Pachon, MD Less <<
NCT01173809 Atrial Fibrillation Phase 3 Completed - United States, Texas ... More >> St.David's Medical Center Austin, Texas, United States, 78705 Less <<
NCT00724581 Atrial Fibrillation PHASE4 UNKNOWN 2025-12-09 Aarhus University Hospital, Sk... More >>ejby, Aarhus, DK-8200, Denmark Less <<
NCT02307591 Ebola Virus Disease Phase 2 Phase 3 Withdrawn(The Study could not ... More >>be started due to an insufficient number of new EVD cases.) Less << - -
NCT02750319 Thoracic Surgery ... More >> Atrial Fibrillation in High Risk Patients Less << Phase 3 Recruiting April 2019 United States, Missouri ... More >> University of Washington School of Medicine in St. Louis Recruiting Saint Louis, Missouri, United States, 63110 Contact: Bryan Meyers, MD    314-362-4533       Principal Investigator: Bryan Meyers, MD          United States, New Jersey Memoral Sloan Kettering Basking Ridge (Consent only) Recruiting Basking Ridge, New Jersey, United States Contact: David Amar, MD    212-639-6798       Memorial Sloan Kettering Monmouth (Consent only) Recruiting Middletown, New Jersey, United States, 07748 Contact: David Amar, MD    212-639-6798       Memorial Sloan Kettering Bergen (Consent only) Recruiting Montvale, New Jersey, United States, 07645 Contact: David Amar, MD    212-639-6798       United States, New York Memorial Sloan Kettering Commack (Consent only) Recruiting Commack, New York, United States, 11725 Contact: David Amar, MD    212-639-6798       Memorial Sloan Kettering Westchester (Consent only) Recruiting Harrison, New York, United States, 10604 Contact: David Amar, MD    212-639-6798       Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: David Amar, MD    212-639-6798       Contact: David R Jones, MD    212-639-6428       Principal Investigator: David Amar, MD          Memorial Sloan Kettering Rockville Centre (Consent only) Recruiting Rockville Centre, New York, United States, 11570 Contact: David Amar, MD    212-639-6798 Less <<
NCT01266681 Atrial Fibrillation Not Applicable Unknown - United Kingdom ... More >> Eastbourne General Hospital Not yet recruiting Eastbourne, East Sussex, United Kingdom, BN21 2UD Sub-Investigator: Oliver Waller, Bsc (hons) Less <<
NCT02341105 Atrial Fibrillation Phase 4 Unknown November 2017 Canada, Ontario ... More >> Hamilton Health Sciences Recruiting Hamilton, Ontario, Canada, L8L 2X2 Contact: Guy Amit, MD    905-527-4322 ext 40453 Less <<
NCT00845780 Persistent Atrial Fibrillation Phase 4 Completed - Netherlands ... More >> University Medical Center Groningen Groningen, Netherlands, 9700 RB Less <<
NCT03153072 Supraventricular Tachycardia Phase 2 Withdrawn(decision of the inve... More >>stigator) Less << - France ... More >> CHU Amiens Picardie Amiens, Picardie, France, 80054 Less <<
NCT01422148 Atrial Fibrillation Not Applicable Recruiting January 2020 United States, Massachusetts ... More >> Baystate Medical Center Recruiting Springfield, Massachusetts, United States, 01107 Contact: Barbara Burkott, BN, BSNCCRP    413-794-0000 ext 1305    barbara.burkott@baystatehealth.org Less <<
NCT01558128 Cardiac Disease Not Applicable Terminated(Insufficient Recrui... More >>tment) Less << - United States, New York ... More >> Weill Cornell Medical College New York, New York, United States, 10065 Less <<
NCT02924285 Heart Diseases ... More >> Cardiomyopathies Ventricular Premature Complexes Less << Phase 3 Recruiting October 2019 Germany ... More >> Heart Center Leipzig Recruiting Leipzig, Germany Contact: Katharina Schöne, MD       schoene_katha@t-online.de Less <<
NCT01558128 - Terminated(Insufficient Recrui... More >>tment) Less << - -
NCT01817439 Atrial Fibrillation PHASE3 UNKNOWN 2025-05-15 Western Galilee Hospital, Naha... More >>ria, 972, Israel Less <<
NCT03413150 Atrial Fibrillation|Atrial Tac... More >>hycardia Less << COMPLETED 2025-04-12 -
NCT03221764 Atrial Fibrillation ... More >> Lung Transplant; Complications Less << Phase 2 Recruiting July 31, 2019 United States, Kentucky ... More >> Jewish Hospital Recruiting Louisville, Kentucky, United States, 40202 Contact: Victor van Berkel, MD, PhD    502-588-7600    victor.vanberkel@ulp.org    Principal Investigator: Victor van Berkel, MD, PhD          Sub-Investigator: Matthew Fox, MD          Sub-Investigator: William Whited, MD Less <<
NCT03299517 Arrhythmias Ventricular Phase 4 Recruiting August 2, 2022 Brazil ... More >> Instituto do Coração - HMFMUSP Recruiting São Paulo, SP, Brazil, 05403000 Contact: Alexandre Soeiro, MD    5511-2661-5299    alexandre.soeiro@bol.com.br Less <<
NCT02668432 New Onset Atrial Fibrillation|... More >>Severe Sepsis|Septic Shock Less << PHASE4 TERMINATED 2018-09-20 University Hospital, San Anton... More >>io, Texas, 78229, United States Less <<
NCT01097330 Defibrillators, Implantable ... More >> Tachycardia, Ventricular Less << Phase 3 Terminated(Anticipated non-fea... More >>sibility of recruitment objectives) Less << December 2014 United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas Texas Cardiac Arrhythmia Research Foundation Austin, Texas, United States, 78705 United States, Virginia University of Virginia Health System Charlottesville, Virginia, United States, 22908 Canada, Ontario Hamilton Health Sciences Hamilton, Ontario, Canada, L8L 2X2 Southlake Regional Health Centre Newmarket, Ontario, Canada, L3Y 2P9 University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Canada, Quebec McGill University Health Center Montreal, Quebec, Canada, H3G 1A4 Canada Institut Universitaire de Cardiologie et Pneumologie de Québec Quebec, Canada, G1V 4G5 China Beijng Fuwai Heart Hospital Beijing, China, 100037 Less <<
NCT03193749 Chagas Cardiomyopathy Phase 3 Recruiting December 2020 Colombia ... More >> Fundación Cardioinfantil - Instituto de Cardiología Recruiting Bogotá, Colombia Contact: Eliana Vaquiro, RN, CCRN    6672727 ext 73200    evaquiro@cardioinfantil.org Less <<
NCT03432663 Atrial Fibrillation Phase 4 Completed - Mexico ... More >> Hospital Universitario "Dr. José Eleuterio González". Universidad Autónoma de Nuevo León Monterrey, Nuevo León, Mexico, 64460 Less <<
NCT05543278 Surgery, Cardiac|Atrial Fibril... More >>lation Less << PHASE4 NOT_YET_RECRUITING 2025-12-25 -
NCT06262932 Atrial Fibrillation PHASE4 COMPLETED 2024-12-31 Police general hospital, Bangk... More >>ok, 10330, Thailand Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.55mL

0.31mL

0.15mL

7.75mL

1.55mL

0.77mL

15.50mL

3.10mL

1.55mL

References

 

Historical Records

Categories