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Chemistry
Life Science
Catalysts Ligands
Materials Science
Pharmaceutical Intermediate
Catalysts Ligands
Achiral Nitrogen Ligands
Pyridine and Phenanthroline Ligands (277)
Other Achiral Nitrogen Ligands (52)
Achiral Oxygen Ligands
Achiral Oxygen Ligand (55)
Achiral Phosphine Ligands
Alkyl-phosphine Ligands (18)
Aryl-phosphine Ligands (85)
2-(Diphenylphosphaneyl)Benzaldehyde (5)[1,1'-Biphenyl]-2-Yldi-Tert-Butylphosphane (4)Triphenylphosphine Oxide (7)
Bis-phosphine Ligands (90)
Monophosphine Ligands (255)
Multi-phosphine Ligands (5)
Chiral Nitrogen Ligands
BINAM Ligands (14)
Chiral Bis-nitrogen Ligands (82)
Salen Ligands (7)
Other Chiral Nitrogen Ligands (62)
Chiral Oxazoline Ligands
BOX Ligands (526)
Chiral Mono Oxazoline Ligands (382)
Ferrocenyl-oxazoline Ligands (10)
PHOX Ligands (231)
TOX Ligands (6)
Other Oxazoline Ligands (18)
Chiral Oxygen Ligands
BINOLs (74)
BIPHENs (1)
Chiral Diphenols (112)
Other Chiral Oxygen Ligands (24)
Chiral Phosphine Ligands
Atropisomeric Bisphosphine Ligands (219)
BIDIME and BIBOP Ligands (86)
BIDIME-BIBOP (7)
2,2',3,3'-Tetrahydro-4,4'-Bibenzo[D][1,3]Oxaphosphole (7)
Chiral Aminophosphine Ligands (48)
Chiral Ferrocenyl Phosphine Ligands (130)
Chiral Phosphoramidite Ligands (191)
Duphos and BPE Ligands (35)
PHOX Ligands (231)
Sadphos Ligands (294)
Other C-Chiral Ligands (76)
Other P-Chiral Ligands (16)
Main-Group Metals
Aluminum (9)
Tin (3)
Metalloids
Metalloid (5)
Photoredox Catalysts
Organic-dye Photoredox Catalysts (80)
Photoredox Acridinium Catalysts (22)
Photoredox Carbazole Catalysts (9)
Photoredox Iridiums Catalysts (100)
Photoredox Rutheniums Catalysts (37)
Other Photoredox Catalysts (12)
Transition Metals
Cobalt (98)
Copper (127)
Gold (104)
Iridium (65)
Iron (112)
Manganese (48)
Molybdenum (17)
Nickel (111)
Osmium (3)
Palladium (315)
Platinum (80)
Rhenium (6)
Rhodium (180)
Ruthenium (220)
Silver (37)
Tantalum (1)
Titanium (12)
Tungsten (6)
Vanadium (7)
Zinc (68)
Other Cheap Metals (6)
Chemistry
Asymmetric Synthesis
Chiral Building Blocks (18089)
Chiral Resolution Reagents (63)
Boronic Acids/Esters
1,3,2-Dioxaborinane (392)
Boronic Acids (13046)
MIDA Boronates (363)
Pinacol Boronates (16046)
Pinanediol Boronates (98)
Potassium Organotrifluoroborate Salts (1072)
Other Boronates (132)
Chemical Biology
Glycoscience (184)
Monosaccharide (148)Polysaccharide (11)
Peptide Chemistry (460)
Amino Acid (111)Peptides (134)Resins for Solid Phase Peptide Synthesis (51)
Click Chemistry
Alkyne Linkers (495)
Azide Linkers (669)
CuAAC Auxiliary Reagents (13)
Copper Ligands for CuAAC Reactions (8)Copper Sources for CuAAC Reactions (2)Reducing Agents for CuAAC Reactions (3)
Cyclooctyne Linkers (335)
BCN Linkers (107)DBCO Linkers (199)DIBO Linkers (1)DIFO Linkers (3)OCT Linkers (25)
Ligands for Staudinger Reactions (8)
Strained Alkene Linkers (212)
2E-TCO Linkers (36)4E-TCO Linkers (176)
SuFEx Reagents (95)
Aliphatic Sulfonyl Fluorides (9)Aminosulfonyl Fluorides (6)Arylsulfonyl Fluorides (77)Sulfonyl Fluoride Esters (3)
Tetrazine Linkers (128)
Fluorine Chemistry
Aliphatic Fluorinated Building Blocks (763)
Aromatic Fluorinated Building Blocks (9406)
Bis(trifluoromethane)sulfonimides (49)
Difluoromethoxylated Building Blocks (231)
Difluoromethylated Building Blocks (350)
Hexafluorophosphates (62)
Monofluoromethylated Building Blocks (73)
Polyfluoroalkanes (85)
SF5-Containing Building Blocks (72)
Sulfonyl Fluorides (66)
Tetrafluoroborates (138)
Triflates (84)
Trifluoroborates (212)
Trifluoromethoxylated Building Blocks (560)
Trifluoromethylated Building Blocks (4499)
Trifluoromethylthiolated Building Blocks (49)
Heterocyclic Building Blocks
Acridines (640)
1,2,3,4-Tetrahydroacridine (9)9,10-Diphenylacridin-10-Ium (6)Acridine (45)
Aliphatic Heterocycles (379)
(1R,5S)-3-Azabicyclo[3.1.0]Hexane (11)1,2-Dithiolane (5)1,4-Diazepan-2-One (5)1,4-Diazepan-5-One (9)1,4-Dioxane (17)1,4-Oxazepane (8)10,11-Dihydro-5H-Dibenzo[B,F]Azepine (9)11,12-Didehydro-5,6-Dihydrodibenz[B,F]Azocine (14)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Glycyl)-2,2-Dimethyloxazolidine-4-Carboxylic Acid (9)3H-Diazirine (10)4-Benzyl-1,4-Oxazepane (5)Tetrahydro-2H-Thiopyran 1,1-Dioxide (8)
Aromatic Heterocycles (118)
1,2,4,5-Tetrazine (8)3,4-Dihydronaphthalen-2(1H)-One (23)
Azetidines (2937)
Alcohols (18)Amides (102)Amines (17)Aryls (44)Bromides (7)Carboxylic Acids (17)Chlorides (10)Esters (11)Ethers (18)Fluorinated Building Blocks (20)Ketones (16)Nitriles (5)Sulfamides (5)1-(Azetidin-1-Yl)-2-Bromoethan-1-One (3)1-(Azetidin-3-Yl)-1H-Pyrazole (7)1-(Phenylsulfonyl)Azetidine (7)1-Benzhydrylazetidine (13)1-Benzylazetidine (6)1-Methylazetidine (6)1-Phenylazetidine (8)2,7-Diazaspiro[3.5]Nonane (7)2-Azaspiro[3.3]Heptane (11)2-Imino-N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Thiazol-4-Yl)Acetamide (3)3-Bromoazetidine (3)3-Methylazetidin-3-Ol (3)3-Methyleneazetidine (8)4-(Azetidin-1-Yl)Piperidine (6)Azetidin-2-One (11)Azetidin-2-Ylmethanol (7)Azetidin-3-Amine (4)Azetidin-3-Ol (11)Azetidin-3-Yl Acetate (3)Azetidin-3-Ylmethanamine (3)Azetidine-2-Carboxylic Acid (6)Azetidine-3-Carboxylic Acid (5)Benzyl Azetidine-1-Carboxylate (9)Methyl Azetidine-2-Carboxylate (3)N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-Phenylacetamide (5)Tert-Butyl Azetidine-1-Carboxylate (64)Oxetanes (9)Piperidines (16)Pyridines (4)Pyrimidines (4)Pyrrolidines (12)Spiroes (85)Tetrahydropyrans (6)
Benzimidazoles (4398)
Alcohols (11)Aldehydes (5)Amides (26)Amines (19)Aryls (40)Bromides (8)Carboxylic Acids (6)Chlorides (15)Esters (12)Ethers (17)Fluorinated Building Blocks (14)Sulfides (7)Benzimidazole-Carboxylic Acid (42)Piperidines (18)Pyridines (6)(1H-Benzo[D]Imidazol-2-Yl)Methanamine (7)(1H-Benzo[D]Imidazol-2-Yl)Methanol (14)1,2-Diphenyl-1H-Benzo[D]Imidazole (7)1-Benzyl-1H-Benzo[D]Imidazole (6)1-Ethyl-1H-Benzo[D]Imidazole (4)1-Methyl-1H-Benzo[D]Imidazole (47)1-Phenyl-1H-Benzo[D]Imidazole (4)1H-Benzo[D]Imidazol-2-Amine (7)1H-Benzo[D]Imidazol-5-Amine (4)1H-Benzo[D]Imidazol-6-Amine (6)1H-Benzo[D]Imidazole-2-Carbaldehyde (5)1H-Benzo[D]Imidazole-2-Carboxylic Acid (7)1H-Benzo[D]Imidazole-2-Thiol (10)1H-Benzo[D]Imidazole-4-Carboxylic Acid (6)1H-Benzo[D]Imidazole-5-Carboxylic Acid (4)2-((Pyridin-2-Ylmethyl)Thio)-1H-Benzo[D]Imidazole (7)2-(1H-Benzo[D]Imidazol-2-Yl)Ethan-1-Amine (6)2-(Chloromethyl)-1H-Benzo[D]Imidazole (9)2-Benzyl-1H-Benzo[D]Imidazole (7)2-Bromo-1H-Benzo[D]Imidazole (4)2-Chloro-1H-Benzo[D]Imidazole (17)2-Methyl-1H-Benzo[D]Imidazole (20)4-Bromo-1H-Benzo[D]Imidazole (14)4-Methyl-1H-Benzo[D]Imidazole (7)5,6-Dichloro-1H-Benzo[D]Imidazole (4)5-Bromo-1H-Benzo[D]Imidazole (13)5-Chloro-1H-Benzo[D]Imidazole (14)5-Methoxy-1H-Benzo[D]Imidazole (2)5-Methyl-1H-Benzo[D]Imidazole (10)6-Chloro-1H-Benzo[D]Imidazole (25)Methyl (1H-Benzo[D]Imidazol-2-Yl)Carbamate (5)Methyl 1H-Benzo[D]Imidazole-2-Carboxylate (3)Tert-Butyl 1H-Benzo[D]Imidazole-1-Carboxylate (3)
Benzisoxazoles (1232)
Amides (4)Amines (4)Fluorinated Building Blocks (4)Piperidines (4)3-Chlorobenzo[D]Isoxazole (7)3-Methylbenzo[D]Isoxazole (8)6-Bromobenzo[D]Isoxazole (5)Benzo[C]Isoxazole (5)Benzo[D]Isoxazol-3-Amine (8)
Benzodioxans (693)
Alcohols (8)Amines (5)(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Methanamine (3)2,3-Dihydrobenzo[B][1,4]Dioxine-2-Carboxylic Acid (3)2,3-Dihydrobenzo[B][1,4]Dioxine-6-Carboxylic Acid (3)6-Bromo-2,3-Dihydrobenzo[B][1,4]Dioxine (6)
Benzofurans (3729)
Alcohols (18)Aldehydes (4)Amides (7)Amines (13)Anhydrides (13)Aryls (12)Bromides (18)Carboxylic Acids (9)Chlorides (14)Esters (33)Ethers (2)Fluorinated Building Blocks (11)Iodides (4)Ketones (10)Nitroes (5)Benzofuran-Carboxylic Acid (67)Dimethoxyisobenzofuran (4)Fluorobenzofuran (19)Fluoroisobenzofuran (5)Methoxyisobenzofuran (4)Methylbenzofuran (25)Piperidines (5)Spiroes (5)1-(Benzofuran-2-Yl)Ethan-1-One (3)2,2-Dimethyl-2,3-Dihydrobenzofuran (7)2,3-Dihydrobenzofuran-3-Amine (11)2,3-Dihydrobenzofuran-5-Amine (3)2,3-Dihydrobenzofuran-7-Amine (5)2-(Benzofuran-3-Yl)Acetic Acid (3)2-Bromodibenzo[B,D]Furan (6)2-Ethylbenzofuran (3)2-Methylbenzofuran (5)3-Methylbenzofuran (4)4-Bromobenzofuran (3)4-Phenyldibenzo[B,D]Furan (8)5,7,8-Trimethylchromane (3)5-Bromo-2,3-Dihydrobenzofuran (6)5-Chloro-2,3-Dihydrobenzofuran (5)5-Fluoro-2,3-Dihydrobenzofuran (5)5-Methoxyisobenzofuran-1(3H)-One (5)6-Bromo-2,3-Dihydrobenzofuran (7)6-Fluoro-2,3-Dihydrobenzofuran (6)6-Methoxybenzofuran (4)7-Bromo-2,3-Dihydrobenzofuran (6)7-Bromobenzofuran (6)7-Fluoro-2,3-Dihydrobenzofuran (6)Benzofuran-2(3H)-One (7)Benzofuran-2-Carbaldehyde (5)Benzofuran-2-Carboxylic Acid (21)Benzofuran-2-Ylboronic Acid (8)Benzofuran-3(2H)-One (15)Benzofuran-3-Carboxylic Acid (6)Benzofuran-3-Yl(Phenyl)Methanone (11)Methyl Benzofuran-2-Carboxylate (6)
Benzothiazoles (2480)
Alcohols (6)Aldehydes (5)Amides (23)Amines (30)Aryls (10)Bromides (11)Carboxylic Acids (5)Chlorides (6)Esters (5)Ethers (15)Fluorinated Building Blocks (7)Nitroes (5)Sulfamides (6)Thioesters (12)Benzothiazole-Carboxylic Acid (26)Bromobenzothiazole (7)Dichlorobenzothiazole (10)Methoxybenzothiazole (4)Methylbenzothiazole (7)Morpholines (4)2-(Methylthio)Benzo[D]Thiazole (6)2-Bromobenzo[D]Thiazole (28)2-Chlorobenzo[D]Thiazole (21)2-Methylbenzo[D]Thiazole (26)4-Bromobenzo[D]Thiazole (9)4-Chlorobenzo[D]Thiazole (7)4-Fluorobenzo[D]Thiazole (6)4-Methylbenzo[D]Thiazole (10)5-Chlorobenzo[D]Thiazole (5)5-Nitrobenzo[D]Thiazole (3)6-Bromobenzo[D]Thiazole (7)6-Chlorobenzo[D]Thiazole (6)6-Fluorobenzo[D]Thiazole (5)6-Methoxybenzo[D]Thiazole (6)6-Methylbenzo[D]Thiazole (6)6-Nitrobenzo[D]Thiazole (3)7-Bromobenzo[D]Thiazole (8)7-Chlorobenzo[D]Thiazole (6)7-Fluorobenzo[D]Thiazole (9)Benzo[D]Thiazol-2-Amine (30)Benzo[D]Thiazol-5-Amine (3)Benzo[D]Thiazol-6-Amine (3)Benzo[D]Thiazol-6-Ol (2)Benzo[D]Thiazole-2-Carbonitrile (11)Benzo[D]Thiazole-2-Thiol (11)Benzo[D]Thiazole-6-Carboxylic Acid (5)Methyl Benzo[D]Thiazole-6-Carboxylate (5)
Benzothiophenes (1141)
Amines (6)Aryls (4)Bromides (4)Esters (8)Fluorinated Building Blocks (5)Benzothiophene-Carboxylic Acid (58)2-(Benzo[B]Thiophen-2-Yl)-4,5-Dihydrooxazole (6)2-Methylbenzo[B]Thiophene (4)3-Bromobenzo[B]Thiophene (5)3-Chlorobenzo[B]Thiophene (6)3-Methylbenzo[B]Thiophene (4)4,5,6,7-Tetrahydrobenzo[B]Thiophene (21)5-Bromobenzo[B]Thiophene (3)5-Chlorobenzo[B]Thiophene (4)6-Bromobenzo[B]Thiophene (4)7-Bromobenzo[B]Thiophene (5)Benzo[B]Thiophen-2-Amine (5)Benzo[B]Thiophen-2-Ylboronic Acid (5)Benzo[B]Thiophene-2-Carbaldehyde (7)Benzo[B]Thiophene-2-Carbonitrile (3)Benzo[B]Thiophene-2-Carboxylic Acid (32)Benzo[B]Thiophene-3-Carbaldehyde (6)Ethyl Benzo[B]Thiophene-2-Carboxylate (9)Methyl Benzo[B]Thiophene-2-Carboxylate (27)
Benzoxazoles (2831)
Amides (33)Amines (7)Bromides (10)Carboxylic Acids (4)Chlorides (11)Esters (4)Ethers (6)Fluorinated Building Blocks (5)Nitroes (5)Benzoxazole-Carboxylic Acid (25)Phenyl-Benzoxazole (2)2-Chlorobenzo[D]Oxazole (11)2-Methylbenzo[D]Oxazole (26)2-Phenylbenzo[D]Oxazole (22)3-Phenylbenzo[D]Oxazol-3-Ium (8)5-Bromobenzo[D]Oxazole (3)5-Chlorobenzo[D]Oxazole (5)5-Methylbenzo[D]Oxazole (3)6-Chlorobenzo[D]Oxazole (4)Benzo[D]Oxazol-2-Amine (16)Benzo[D]Oxazole-2-Thiol (6)Methyl Benzo[D]Oxazole-2-Carboxylate (3)
Carbazole Series (501)
Carbazolyl-Phenyl-Boronic Acid/Ester (14)1-Methyl-9H-Carbazole (7)2,3,4,9-Tetrahydro-1H-Carbazol-1-One (7)2-Bromo-9H-Carbazole (4)3,9-Diphenyl-9H-Carbazole (7)3-(Tert-Butyl)-9H-Carbazole (3)3-Bromo-9-Phenyl-9H-Carbazole (16)3-Bromo-9H-Carbazole (4)3-Chloro-9H-Carbazole (3)3-Methyl-9H-Carbazole (3)7H-Benzo[C]Carbazole (5)9-([1,1'-Biphenyl]-4-Yl)-9H-Carbazole (9)9-(P-Tolyl)-9H-Carbazole (5)9-Benzyl-9H-Carbazole (7)9-Ethyl-9H-Carbazole (9)
Cinnolines (355)
Cinnoline (14)
Dioxolanes (1597)
Alcohols (4)Amines (4)Aryls (16)Bromides (6)Carboxylic Acids (4)Esters (7)Ketones (5)Sulfonates (4)Spiroes (23)(3As,6As)-Tetrahydrofuro[3,4-D][1,3]Dioxole (6)1,3-Dioxolan-2-One (11)2,2-Difluorobenzo[D][1,3]Dioxole (19)2,2-Dimethyl-1,3-Dioxolane (29)2,2-Dimethylbenzo[D][1,3]Dioxole (7)2-Phenyl-1,3-Dioxolane (18)4-Bromobenzo[D][1,3]Dioxole (6)4-Methyl-1,3-Dioxolane (5)5-Bromobenzo[D][1,3]Dioxole (12)5-Chlorobenzo[D][1,3]Dioxole (5)5-Nitrobenzo[D][1,3]Dioxole (4)9-((3As,4R,6Ar)-Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-9H-Purine (7)Benzo[D][1,3]Dioxol-5-Amine (3)
Dioxoles (13)
Epoxides (425)
Aliphatic Chain Hydrocarbons (7)Amides (10)Aryls (25)Esters (9)Ethers (13)Ketones (4)Nitroes (5)Sulfonates (7)Epoxy (5)Oxirane (61)7-Oxabicyclo[4.1.0]Heptane (7)Ethyl Oxirane-2-Carboxylate (4)Oxiran-2-Ylmethanol (3)Spiroes (5)Other Aliphatic Heterocycles (11)
Furans (6946)
Alcohols (8)Aldehydes (15)Alkenyls (9)Amides (30)Amines (22)Aryls (39)Bromides (13)Carboxylic Acids (35)Chlorides (9)Esters (21)Ethers (10)Fluorinated Building Blocks (4)Ketones (10)Nitriles (7)Nitroes (8)Sulfides (6)Aminodihydrofuran (7)Bromofuran (32)Chlorofuran (2)Chlorofuro (11)Cyanofuran (53)Dibromofuran (5)Dihydrofuran (31)Dihydrofuro (16)Dihydroxydihydrofuran (8)Dimethylfuran (10)Formylfuran (10)Hexahydrofuro (6)Hydroxydihydrofuran (31)Methyldihydrofuran (11)Methylfuran (58)Nitrofuran (10)Piperazines (4)Quinolines (3)2,3-Dihydrofuran-3-One (9)2-(Bromomethyl)Furan (3)2-(Chloromethyl)Furan (3)2-(Furan-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (6)2-Bromofuran (21)2-Chlorofuran (3)2-Methylfuran (37)2-Nitrofuran (9)3-Bromofuran (13)4-Methylisobenzofuran-1(3H)-One (3)5-Nitro-2,3-Dihydrobenzofuran (3)5-Phenylfuran-2-Carbaldehyde (9)5-Phenylfuran-2-Carboxylic Acid (6)6-Chloro-2,3-Dihydrobenzofuran (3)6-Fluoroisobenzofuran-1(3H)-One (3)7-Chloro-2,3-Dihydrobenzofuran (3)Ethyl Furan-2-Carboxylate (6)Furan-2,5-Dione (8)Furan-2-Carbaldehyde (21)Furan-2-Carbonitrile (8)Furan-2-Carboxylic Acid (30)Furan-2-Ylmethanol (7)Furan-3-Carboxylic Acid (11)Furo[3,2-B]Pyridine (7)Furo[3,2-C]Pyridine (7)Methyl Furan-2-Carboxylate (20)N-(Furan-2-Ylmethyl)Aniline (5)
Imidazoles (2745)
Alcohols (27)Aldehydes (21)Alkenyls (7)Amides (26)Amines (38)Aryls (50)Bromides (16)Carboxylic Acids (42)Chlorides (15)Esters (34)Ethers (6)Fluorinated Building Blocks (25)Iodides (12)Ketones (7)Nitroes (13)Sulfamides (7)Trifluoromethyls (12)Biimidazole (5)Bromoimidazo (102)Dibromoimidazo (8)Dichloroimidazo (9)Dihydroimidazo (25)Imidazopyridine (263)Methoxyimidazo (13)Methylimidazo (121)Tetrahydroimidazo (37)Pyridines (4)Pyrrolidines (2)1,1'-Diphenyl-4,4',5,5'-Tetrahydro-1H,1'H-2,2'-Biimidazole (11)1,2-Dimethyl-1H-Imidazole (6)1,3-Diphenyl-1H-Imidazol-3-Ium (14)1,3-Diphenyl-4,5-Dihydro-1H-Imidazol-3-Ium (5)1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One (3)1-(Phenylsulfonyl)-1H-Imidazole (5)1-Benzyl-1H-Imidazole (20)1-Decyl-3-Methyl-1H-Imidazol-3-Ium (14)1-Ethyl-1H-Imidazole (3)1-Isopropyl-1H-Imidazole (5)1-Phenyl-1H-Imidazole-4-Carboxylic Acid (5)1-Trityl-1H-Imidazole (15)1H-Imidazo[4,5-B]Pyridine (14)1H-Imidazo[4,5-C]Pyridine (12)1H-Imidazol-2-Amine (6)1H-Imidazole-2-Carboxylic Acid (7)1H-Imidazole-4-Carbonitrile (2)1H-Imidazole-4-Carboxylic Acid (4)2-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole (5)2-Bromo-1H-Imidazole (13)2-Bromoimidazo[1,2-A]Pyridine (5)2-Ethyl-1H-Imidazole (3)2-Methyl-1-Phenyl-1H-Imidazole (11)2-Methylimidazo[1,2-A]Pyridine (8)2-Phenyl-1H-Benzo[D]Imidazole (26)2-Phenyl-1H-Imidazole (26)2-Phenylimidazo[1,2-A]Pyridine (12)2-Propyl-1H-Imidazole (5)3-Bromoimidazo[1,2-A]Pyrazine (6)3-Bromoimidazo[1,2-A]Pyridine (26)3-Bromoimidazo[1,2-A]Pyrimidine (6)3-Iodoimidazo[1,2-A]Pyridine (10)3-Methylimidazo[1,2-A]Pyridine (3)4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine (5)4-(1H-Imidazol-1-Yl)Benzaldehyde (7)4-Bromo-1-Phenyl-1H-Imidazole (9)4-Methyl-1-Phenyl-1H-Imidazole (7)4-Methyl-1H-Imidazole (6)4-Phenyl-1H-Imidazole (8)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine (15)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyridine (11)5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine (11)5-Benzyl-1H-Imidazole (1)5-Bromoimidazo[1,2-A]Pyridine (6)5-Chloro-1H-Imidazole (2)5-Fluoro-1H-Benzo[D]Imidazole (12)5-Iodo-1H-Imidazole (4)5-Methylimidazo[1,2-A]Pyridine (4)5-Phenyl-1H-Imidazole (6)6,7-Dihydro-5H-Pyrrolo[1,2-A]Imidazole (9)6-Bromoimidazo[1,2-A]Pyrazine (11)6-Bromoimidazo[1,2-A]Pyridine (14)6-Bromoimidazo[1,2-A]Pyrimidine (5)6-Chloroimidazo[1,2-A]Pyridine (4)6-Chloroimidazo[1,2-B]Pyridazine (30)7-Methylimidazo[1,2-A]Pyridine (3)8-Bromoimidazo[1,2-A]Pyrazine (7)8-Bromoimidazo[1,2-A]Pyridine (15)8-Chloroimidazo[1,2-A]Pyrazine (8)8-Chloroimidazo[1,2-A]Pyridine (7)8-Fluoroimidazo[1,2-A]Pyridine (3)8-Methylimidazo[1,2-A]Pyridine (9)Ethyl 1H-Imidazole-2-Carboxylate (6)Ethyl 2-(Imidazo[1,2-A]Pyridin-3-Yl)Acetate (3)Ethyl Imidazo[1,2-A]Pyridine-2-Carboxylate (26)Ethyl Imidazo[1,2-A]Pyridine-3-Carboxylate (13)Imidazo[1,2-A]Pyridin-3-Amine (7)Imidazo[1,2-A]Pyridin-8-Amine (7)Imidazo[1,2-A]Pyridin-8-Ol (3)Imidazo[1,2-A]Pyridine-2-Carbaldehyde (8)Imidazo[1,2-A]Pyridine-2-Carboxylic Acid (21)Imidazo[1,2-A]Pyridine-3-Carbaldehyde (9)Imidazo[1,2-A]Pyridine-3-Carboxylic Acid (14)Imidazo[1,2-A]Pyridine-7-Carboxylic Acid (5)Imidazo[1,2-A]Pyridine-8-Carboxylic Acid (6)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid (5)Imidazo[1,2-C]Pyrimidine (6)Imidazo[1,5-A]Pyrazine (9)Imidazo[2,1-B]Thiazole (14)Methyl 1H-Imidazole-2-Carboxylate (4)Methyl 1H-Imidazole-5-Carboxylate (8)Methyl Imidazo[1,2-A]Pyridine-8-Carboxylate (3)Tert-Butyl 1H-Imidazole-1-Carboxylate (6)
Imidazolidines (1118)
Amides (18)Aryls (9)Carboxylic Acids (3)Methylimidazolidine (3)Oxoimidazolidine (8)Thioxoimidazolidin (9)Spiroes (4)(3Ar,6As)-Tetrahydro-1H-Thieno[3,4-D]Imidazol-2(3H)-One (18)1-Phenylimidazolidin-2-One (8)3-Phenyl-2-Thioxoimidazolidin-4-One (6)3-Phenylimidazolidine-2,4-Dione (4)Imidazolidin-2-One (16)Imidazolidine-2,4-Dione (17)
Imidazolines (679)
Amides (16)Amines (4)Aryls (14)Spiroes (4)
Indazoles (3029)
Alcohols (17)Aldehydes (9)Amides (6)Amines (18)Aryls (7)Bromides (25)Carboxylic Acids (19)Chlorides (9)Esters (8)Ethers (9)Fluorinated Building Blocks (10)Iodides (12)Nitriles (7)Nitroes (7)Indazol-Amide (3)(1H-Indazol-4-Yl)Boronic Acid (3)(1H-Indazol-6-Yl)Boronic Acid (4)1-(1H-Indazol-1-Yl)Ethan-1-One (7)1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole (17)1-Benzyl-1H-Indazole (5)1-Ethyl-1H-Indazole (6)1H-Indazol-3-Amine (23)1H-Indazol-3-Ol (10)1H-Indazol-4-Amine (12)1H-Indazol-4-Ol (4)1H-Indazol-5-Amine (3)1H-Indazol-6-Amine (5)1H-Indazol-6-Ol (6)1H-Indazol-7-Amine (6)1H-Indazole-3-Carbaldehyde (19)1H-Indazole-3-Carbonitrile (9)1H-Indazole-3-Carboxylic Acid (23)1H-Indazole-4-Carboxylic Acid (9)1H-Indazole-5-Carboxylic Acid (4)1H-Indazole-7-Carboxylic Acid (6)2,3-Dimethyl-2H-Indazole (4)2-Methyl-2H-Indazole (34)3-(Piperidin-4-Yl)-1H-Indazole (5)3-Chloro-1H-Indazole (13)4,5,6,7-Tetrahydro-1H-Indazole (9)4-Chloro-1H-Indazole (18)4-Fluoro-1H-Indazole (22)4-Methoxy-1H-Indazole (7)4-Methyl-1H-Indazole (12)4-Nitro-1H-Indazole (10)5-Bromo-1H-Indazole (12)5-Chloro-1H-Indazole (8)5-Methoxy-1H-Indazole (4)5-Nitro-1H-Indazole (5)6-(Trifluoromethyl)-1H-Indazole (6)6-Bromo-1H-Indazole (22)6-Chloro-1H-Indazole (13)6-Fluoro-1H-Indazole (15)6-Methoxy-1H-Indazole (14)6-Methyl-1H-Indazole (9)6-Nitro-1H-Indazole (9)7-Bromo-1H-Indazole (17)7-Chloro-1H-Indazole (7)7-Fluoro-1H-Indazole (12)7-Methoxy-1H-Indazole (5)7-Nitro-1H-Indazole (11)Methyl 1H-Indazole-4-Carboxylate (10)Methyl 1H-Indazole-5-Carboxylate (3)Methyl 1H-Indazole-6-Carboxylate (9)Methyl 1H-Indazole-7-Carboxylate (8)Methyl 2-Methyl-2H-Indazole-3-Carboxylate (3)Tert-Butyl 1H-Indazole-1-Carboxylate (29)
Indoles (7534)
Alcohols (25)Aldehydes (21)Alkenyls (4)Amides (41)Amines (29)Aryls (50)Bromides (35)Carboxylic Acids (50)Chlorides (26)Esters (56)Ethers (54)Fluorinated Building Blocks (37)Iodides (10)Ketones (15)Nitriles (29)Nitroes (10)Sulfamides (6)Trifluoromethyls (5)Azaindole (41)Benzyloxyindole (1)Biindolinylidene (1)Bromo-Indole-Carboxylic Acid (25)Cyanoindole (5)Dihydroindolo (14)Fluoroindole (5)Formylindole (44)Hydroxyindole (7)Hydroxyisoindoline (2)Isoindole (26)Methoxyindole (8)Nitroindole (5)Piperazines (5)Piperidines (3)Pyridines (5)Pyrimidines (7)(1-(Tert-Butoxycarbonyl)-1H-Indol-2-Yl)Boronic Acid (17)(1H-Indol-2-Yl)Boronic Acid (3)(1H-Indol-2-Yl)Methanol (8)(3As,7As)-Octahydro-1H-Indole (5)(9H-Fluoren-9-Yl)Methyl (2-(1H-Indol-3-Yl)Ethyl)Carbamate (12)1,2,3,4-Tetrahydrocyclopenta[B]Indole (5)1,2-Dimethyl-1H-Indole (3)1-(1H-Indol-1-Yl)Ethan-1-One (9)1-(Phenylsulfonyl)-1H-Indole (26)1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine (8)1-Benzyl-1H-Indole (9)1-Ethyl-1H-Indole (7)1-Methyl-1H-Indole (81)1-Methyl-1H-Indole-2-Carboxylic Acid (8)1-Methyl-1H-Indole-3-Carbaldehyde (9)1-Methyl-1H-Pyrrolo[2,3-B]Pyridine (14)1-Phenyl-1H-Indole (5)1H-Indol-3-Ol (5)1H-Indol-3-Yl Acetate (4)1H-Indol-4-Amine (10)1H-Indol-4-Ol (7)1H-Indol-5-Ol (4)1H-Indol-6-Amine (21)1H-Indol-6-Ol (6)1H-Indol-7-Amine (10)1H-Indole-2-Carbaldehyde (20)1H-Indole-2-Carbonitrile (9)1H-Indole-3-Carbonitrile (17)1H-Indole-3-Carboxylic Acid (28)1H-Indole-4-Carboxylic Acid (10)1H-Indole-5-Carbonitrile (5)1H-Indole-5-Carboxylic Acid (4)1H-Indole-6-Carbonitrile (4)1H-Indole-6-Carboxylic Acid (5)1H-Indole-7-Carbonitrile (6)1H-Indole-7-Carboxylic Acid (7)1H-Pyrrolo[2,3-B]Pyridine-3-Carbaldehyde (14)1H-Pyrrolo[2,3-B]Pyridine-5-Carbaldehyde (5)2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole (12)2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole (13)2,3-Dimethyl-1H-Indole (9)2-(1,3,2-Dioxaborolan-2-Yl)-1-Methyl-1H-Indole (6)2-(1H-Indol-1-Yl)Acetic Acid (5)2-(1H-Indol-3-Yl)Acetic Acid (28)2-(1H-Indol-3-Yl)Ethan-1-Amine (4)2-(1H-Indol-3-Yl)Ethan-1-Ol (10)2-(2-Methyl-1H-Indol-3-Yl)Acetic Acid (5)2-(4-Fluorophenyl)-1H-Indole (4)2-Methyl-1H-Indole-3-Carbaldehyde (3)2-Methyl-1H-Pyrrolo[2,3-B]Pyridine (12)3-(1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione (21)3-(1H-Indol-3-Yl)Propanoic Acid (3)3-(Piperidin-4-Yl)-1H-Indole (8)3-Iodo-1H-Pyrrolo[2,3-B]Pyridine (11)3-Methyl-1H-Indole (40)3H-Indole (8)4-Bromo-1H-Indole (25)4-Chloro-1H-Indole (21)4-Fluoro-1H-Indole (24)4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (6)4-Fluoroindoline-2,3-Dione (3)4-Methoxy-1H-Indole (11)4-Methyl-1H-Indole (22)4-Nitro-1H-Indole (6)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole (4)5-(Benzyloxy)-1H-Indole (7)5-Bromo-1-Methyl-1H-Indole (3)5-Chloro-1H-Indole (61)5-Chloro-1H-Indole-2-Carboxylic Acid (6)5-Chloro-1H-Pyrrolo[2,3-B]Pyridine (12)5-Fluoro-1H-Indole (48)5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (9)5-Fluoroindolin-2-One (4)5-Methoxy-1H-Indole (11)5-Methoxy-2-Methyl-1H-Indole (4)5-Methyl-1H-Indole (32)5-Nitro-1H-Indole (6)6-(Trifluoromethyl)-1H-Indole (5)6-Bromo-1-Methyl-1H-Indole (3)6-Bromo-1H-Indole (15)6-Bromo-1H-Pyrrolo[2,3-B]Pyridine (5)6-Chloro-1H-Indole (19)6-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)6-Fluoro-1H-Indole (17)6-Methoxy-1H-Indole (12)6-Methyl-1H-Indole (27)6-Methyl-1H-Pyrrolo[2,3-B]Pyridine (8)6-Nitro-1H-Indole (8)7-Bromo-1H-Indole (27)7-Bromoindoline-2,3-Dione (3)7-Chloro-1H-Indole (29)7-Fluoro-1H-Indole (24)7-Fluoro-1H-Indole-2-Carboxylic Acid (5)7-Methoxy-1H-Indole (8)7-Methyl-1H-Indole (33)7-Nitro-1H-Indole (11)9H-Pyrido[3,4-B]Indole (5)Benzo[Cd]Indol-2(1H)-One (5)Ethyl 5-Chloro-1H-Indole-2-Carboxylate (5)Ethyl 5-Fluoro-1H-Indole-2-Carboxylate (5)Ethyl 6-Chloro-1H-Indole-2-Carboxylate (5)Ethyl 7-Chloro-1H-Indole-2-Carboxylate (5)Methyl 1H-Indole-4-Carboxylate (9)Methyl 1H-Indole-5-Carboxylate (7)Methyl 1H-Indole-6-Carboxylate (9)Methyl 1H-Indole-7-Carboxylate (7)Methyl 2-(1H-Indol-3-Yl)Acetate (3)N-(2-(1H-Indol-3-Yl)Ethyl)Acetamide (5)Spiro[Indoline-3,4'-Piperidin]-2-One (18)Tert-Butyl 1H-Indole-1-Carboxylate (18)Tert-Butyl 1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate (9)Tert-Butyl 2-(1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate (6)Tert-Butyl 3-(Hydroxymethyl)-1H-Indole-1-Carboxylate (10)Tert-Butyl 3-Bromo-1H-Indole-1-Carboxylate (9)Tert-Butyl 3-Iodo-1H-Indole-1-Carboxylate (7)Tert-Butyl 5-Methoxy-1H-Indole-1-Carboxylate (6)Tryptophan (22)
Indolines (4539)
Alcohols (13)Alkenyls (3)Amides (73)Amines (9)Aryls (20)Bromides (16)Carboxylic Acids (16)Chlorides (14)Esters (9)Ethers (5)Fluorinated Building Blocks (11)Ketones (11)Nitriles (5)Nitroes (9)Aminoindoline (10)Bromoindoline (17)Bromoisoindolin (5)Bromoisoindoline (6)Chloroindolin (4)Chloroisoindoline (3)Dibromoindoline (12)Dichloroindoline (16)Difluoroindoline (1)Dimethylindoline (21)Dioxoindoline (8)Dioxoisoindolin (72)Fluoroindolin (9)Fluoroindoline (9)Fluoroisoindoline (10)Hydroxyindolin (5)Isoindoline (22)Methoxyindoline (12)Methoxyisoindoline (9)Methylindoline (45)Methylisoindoline (18)Nitroindolin (6)Nitroindoline (11)Nitroisoindoline (8)Oxoindoline (32)Oxoisoindoline (16)Spiro-Indoline-Piperidine (34)Spiroes (5)(E)-[3,3'-Biindolinylidene]-2,2'-Dione (5)(Z)-3-((1H-Pyrrol-2-Yl)Methylene)Indolin-2-One (8)(Z)-3-(Phenyl(Phenylamino)Methylene)Indolin-2-One (5)(Z)-3-Benzylideneindolin-2-One (7)1-(Indolin-1-Yl)Ethan-1-One (9)1-Benzylindoline-2,3-Dione (5)1-Methylindolin-2-One (14)1-Methylindoline (3)1-Methylindoline-2,3-Dione (8)2-(1,3-Dioxoisoindolin-2-Yl)Propanoic Acid (3)2-Methylindoline (7)2-Methylisoindolin-1-One (7)3,3-Dimethylindolin-2-One (5)3,3-Dimethylindoline (7)4-Bromoindoline (4)4-Chloroindoline-2,3-Dione (6)4-Methylindoline (3)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline (5)5-Bromoindolin-2-One (5)5-Bromoindoline (8)5-Bromoisoindoline-1,3-Dione (3)5-Chloroindolin-2-One (3)5-Fluoroindoline (3)5-Methoxyindoline (4)5-Methylindolin-2-One (3)5-Methylindoline (3)6-Bromoindolin-2-One (8)6-Bromoindoline-2,3-Dione (4)6-Chloroindolin-2-One (5)6-Chloroindoline (3)6-Chloroindoline-2,3-Dione (5)6-Fluoroindolin-2-One (5)6-Fluoroindoline-2,3-Dione (3)7-Bromoindoline (3)7-Fluoroindolin-2-One (3)7-Fluoroindoline-2,3-Dione (6)7-Methylindoline-2,3-Dione (7)Indoline-2-Carboxylic Acid (3)Methyl Indoline-6-Carboxylate (3)Spiro[Cyclopropane-1,3'-Indolin]-2'-One (6)Tert-Butyl Indoline-1-Carboxylate (24)
Isoquinolines (2761)
Alcohols (4)Amides (10)Amines (12)Bromides (11)Carboxylic Acids (4)Chlorides (14)Esters (7)Ethers (8)Fluorinated Building Blocks (7)Nitriles (4)Bromoisoquinoline (69)Chloroisoquinoline (101)Dibromoisoquinoline (9)Dichloroisoquinoline (14)Dihydroisoquinoline (107)Fluoroisoquinoline (78)Methoxyisoquinoline (59)Methylisoquinoline (59)Nitroisoquinoline (23)1,3-Dichloroisoquinoline (14)1-Bromoisoquinoline (20)1-Chloroisoquinoline (20)1-Methylisoquinoline (9)1H-Benzo[De]Isoquinoline-1,3(2H)-Dione (14)2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One (6)3-Bromoisoquinoline (10)3-Chloroisoquinoline (20)3-Methylisoquinoline (8)4-Bromoisoquinolin-1(2H)-One (3)4-Bromoisoquinoline (33)4-Chloroisoquinoline (11)4-Fluoroisoquinoline (6)5-Bromoisoquinoline (17)5-Chloroisoquinoline (6)5-Methoxyisoquinoline (6)5-Nitroisoquinoline (7)6-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)6-Bromoisoquinoline (9)6-Methoxy-3,4-Dihydroisoquinolin-1(2H)-One (3)7-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)7-Bromoisoquinoline (6)7-Chloroisoquinoline (6)7-Fluoroisoquinoline (3)7-Methoxyisoquinoline (5)8-Bromoisoquinoline (17)8-Chloroisoquinoline (7)8-Fluoroisoquinolin-1(2H)-One (3)8-Fluoroisoquinoline (10)8-Methoxyisoquinoline (7)Isoquinolin-1-Amine (18)Isoquinolin-1-Ol (9)Isoquinolin-3-Amine (13)Isoquinolin-3-Ol (6)Isoquinolin-4-Amine (16)Isoquinolin-4-Ol (9)Isoquinolin-4-Ylboronic Acid (3)Isoquinolin-5-Amine (9)Isoquinolin-5-Ol (7)Isoquinolin-8-Amine (6)Isoquinoline-1-Carbonitrile (7)Isoquinoline-1-Carboxylic Acid (10)Isoquinoline-3-Carboxylic Acid (7)Isoquinoline-4-Carboxylic Acid (12)Isoquinoline-5-Carboxylic Acid (5)Isoquinoline-5-Sulfonyl Chloride (3)Isoquinoline-6-Carboxylic Acid (3)Methyl Isoquinoline-3-Carboxylate (3)Methyl Isoquinoline-4-Carboxylate (6)Tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate (19)
Isothiazoles (359)
Bromides (4)Methylisothiazole (5)Benzo[D]Isothiazol-3(2H)-One 1,1-Dioxide (10)Benzo[D]Isothiazole (12)Isothiazole (47)
Isoxazoles (3433)
Alcohols (8)Aldehydes (9)Amides (16)Amines (25)Aryls (54)Bromides (11)Carboxylic Acids (18)Chlorides (19)Esters (11)Ethers (12)Fluorinated Building Blocks (12)Aminoisoxazole (7)Bromoisoxazole (5)Dihydroisoxazol (2)Dimethylisoxazole (16)Phenylisoxazole (28)(3-Phenylisoxazol-5-Yl)Methanol (7)3-Bromoisoxazole (7)3-Methyl-5-Phenylisoxazole (6)3-Methylisoxazole (30)3-Phenylisoxazol-5-Amine (8)5-(Thiophen-2-Yl)Isoxazole (5)5-Cyclopropylisoxazole (5)5-Methyl-3-Phenylisoxazole (4)5-Methylisoxazole (16)5-Phenylisoxazole-3-Carboxylic Acid (15)Ethyl Isoxazole-3-Carboxylate (8)Ethyl Isoxazole-4-Carboxylate (5)Isoxazol-3-Amine (7)Isoxazol-3-Ylmethanol (3)Isoxazol-5-Amine (15)Isoxazol-5-Ylmethanol (5)Isoxazole-3-Carboxylic Acid (8)Isoxazole-5-Carboxylic Acid (7)Methyl 5-Phenylisoxazole-3-Carboxylate (6)N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-3-Phenylisoxazole-4-Carboxamide (1)
Morpholines (4791)
Alcohols (23)Aldehydes (9)Amides (95)Amines (54)Aryls (137)Bromides (30)Carboxylic Acids (34)Chlorides (24)Esters (31)Ethers (17)Fluorinated Building Blocks (17)Ketones (8)Nitriles (5)Nitroes (12)Phenols (3)Sulfamides (11)Trifluoromethyls (5)Ureas (4)Benzylmorpholine (19)Cyanomorpholine (6)Dimorpholine (3)Ethylmorpholine (9)Isopropylmorpholine (9)Methylmorpholine (59)Morpholinobenzaldehyde (11)Morpholinobenzo (13)Morpholinobenzoic (8)Morpholinoethanone (5)Morpholinoethoxy (1)Morpholinoethyl (5)Morpholinomethyl (16)Morpholinophenyl (14)Morpholinopropoxy (6)Morpholinopyrimidin (6)Morpholinosulfonyl (7)Oxomorpholine (6)Benzothiazoles (4)Piperidines (30)Pyridazines (4)Pyridines (24)Pyrimidines (4)Spiroes (33)Thiazoles (5)(R)-3-Phenylmorpholine (7)(S)-3-Phenylmorpholine (10)2,2-Dimethylmorpholine (5)2,6-Dimethylmorpholine (1)2-(Methoxymethyl)Morpholine (4)2-(Morpholin-2-Yl)Acetic Acid (5)2-Ethylmorpholine (3)2-Isopropylmorpholine (4)2-Methylmorpholine (7)3-(4-Morpholinophenyl)Oxazolidin-2-One (5)3-(Methoxymethyl)Morpholine (4)3-Ethylmorpholine (4)3-Isopropylmorpholine (5)3-Methylmorpholine (13)3-Phenylmorpholine (8)4-(2-Fluorophenyl)Morpholine (8)4-(3-Phenoxypropyl)Morpholine (7)4-(O-Tolyl)Morpholine (6)4-(Pyrazin-2-Yl)Morpholine (5)4-(Pyridin-4-Yl)Morpholine (5)4-(Pyrimidin-2-Yl)Morpholine (9)4-Benzylmorpholin-3-One (6)4-Morpholinoaniline (4)4-Morpholinobenzaldehyde (8)4-Morpholinobenzoic Acid (5)4-Phenylmorpholin-3-One (6)6,6-Dimethylmorpholine-3-Carboxylic Acid (5)Benzyl Morpholine-4-Carboxylate (5)Ethyl Morpholine-2-Carboxylate (4)Methyl 2-(Morpholin-3-Yl)Acetate (3)Methyl Morpholine-2-Carboxylate (4)Methyl Morpholine-3-Carboxylate (10)Morpholin-2-Ylmethanamine (8)Morpholin-2-Ylmethanol (12)Morpholin-3-Ylmethanol (14)Morpholine-2-Carbonitrile (4)Morpholine-2-Carboxylic Acid (12)Morpholine-3-Carboxylic Acid (10)Morpholino(Phenyl)Methanone (11)Tert-Butyl (Morpholin-2-Ylmethyl)Carbamate (3)Tert-Butyl 2-(Bromomethyl)Morpholine-4-Carboxylate (3)Tert-Butyl Morpholine-4-Carboxylate (23)
Naphthyridines (956)
Bromides (4)Carboxylic Acids (3)Fluorinated Building Blocks (4)Ketones (4)1,5-Naphthyridine-3-Carboxylic Acid (6)1,6-Naphthyridine (22)1,7-Naphthyridine (23)2,7-Naphthyridine (5)3-Bromo-1,5-Naphthyridine (8)4-Bromo-1,5-Naphthyridine (5)4-Chloro-1,5-Naphthyridine (6)5,6,7,8-Tetrahydro-1,6-Naphthyridine (22)5,6,7,8-Tetrahydro-1,7-Naphthyridine (6)
Oxadiazoles (3576)
Amides (10)Amines (16)Aryls (12)Bromides (4)Carboxylic Acids (4)Piperidines (4)1,2,4-Oxadiazole (19)1,2,5-Oxadiazole (12)1,3,4-Oxadiazole (25)2,5-Diphenyl-1,3,4-Oxadiazole (6)2-Phenyl-1,3,4-Oxadiazole (26)3-Phenyl-1,2,4-Oxadiazole (23)Benzo[C][1,2,5]Oxadiazole (17)
Oxazines (250)
Phenoxazine (7)2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One (8)3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine (5)6-Amino-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)6-Bromo-2H-Benzo[B][1,4]Oxazin-3(4H)-One (7)6-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)6-Chloro-2H-Benzo[B][1,4]Oxazin-3(4H)-One (8)6-Chloro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)7-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (7)Spiro[Benzo[D][1,3]Oxazine-4,4'-Piperidin]-2(1H)-One (5)
Oxazoles (2053)
Alcohols (9)Amides (10)Amines (16)Aryls (48)Bromides (12)Carboxylic Acids (16)Chlorides (14)Esters (18)Ethers (4)Fluorinated Building Blocks (5)Nitriles (6)Nitroes (4)Bioxazole (12)2-Bromooxazole (7)2-Chlorooxazole (7)2-Methyloxazole (19)2-Phenyloxazole (16)3,4-Diphenylisoxazole (8)4,5-Diphenyloxazole (7)4-(Oxazol-5-Yl)Aniline (3)4-Methyloxazole (9)5-(4-Nitrophenyl)Oxazole (3)5-Methyloxazole (5)6-Bromobenzo[D]Oxazole (3)Ethyl Oxazole-4-Carboxylate (8)Ethyl Oxazole-5-Carboxylate (3)Methyl Oxazole-4-Carboxylate (9)Oxazol-2-Amine (8)Oxazole-4-Carboxylic Acid (4)Oxazolo[4,5-B]Pyridine (7)Oxazolo[5,4-B]Pyridine (5)
Oxazolidines (1196)
Alcohols (6)Amides (49)Amines (4)Anhydrides (5)Aryls (24)Esters (7)Fluorinated Building Blocks (1)Dimethyloxazolidin (3)Dioxooxazolidin (2)Oxazolidinone (2)Phenyloxazolidin (7)Propionyloxazolidin (4)Spiroes (6)(S)-4-Benzyloxazolidin-2-One (1)3-(4-Morpholinophenyl)Oxazolidin-2-One (5)3-Phenyloxazolidin-2-One (4)4-Isopropyloxazolidine (6)Oxazolidine (21)Oxazolidine-2,5-Dione (9)
Oxazolines (1570)
Amides (4)Aryls (8)Esters (6)(3Ar,8As)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (6)(3As,8Ar)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (7)(4R,5S)-4,5-Diphenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (5)(R)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(R)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(S)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (8)(S)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (6)1,3-Bis(4,5-Dihydrooxazol-2-Yl)Benzene (8)2,2'-(1,3-Diphenylpropane-2,2-Diyl)Bis(4,5-Dihydrooxazole) (5)2,2'-(2-Phenylethane-1,1-Diyl)Bis(4,5-Dihydrooxazole) (5)2,3-Dihydropyrazolo[5,1-B]Oxazole (7)2,6-Bis(4,5-Dihydrooxazol-2-Yl)Pyridine (12)2-(6-Benzhydrylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(6-Cyclopropylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(Benzo[B]Thiophen-2-Yl)-4,5-Dihydrooxazole (6)2-(Pyridin-2-Ylmethyl)-4,5-Dihydrooxazole (14)2-(Quinolin-2-Yl)-4,5-Dihydrooxazole (7)2-Phenyl-4,5-Dihydrooxazole (17)4,4',5,5'-Tetrahydro-2,2'-Bioxazole (10)4-(Tert-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)4-Isopropyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)Bis((3Ar,8As)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazol-2-Yl)Methane (5)Bis((3As,8Ar)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazol-2-Yl)Methane (5)Bis(4,5-Dihydrooxazol-2-Yl)Methane (22)
Oxetanes (799)
Alcohols (24)Alkenyls (4)Amides (14)Amines (28)Aryls (20)Bromides (9)Carboxylic Acids (7)Esters (10)Ethers (6)Fluorinated Building Blocks (5)Iodides (6)Sulfonates (5)Methyloxetane (11)Azetidines (9)Piperidines (8)Pyrrolidines (4)Spiroes (26)
Phthalazines (420)
Amides (6)Dihydrophthalazine (12)Phthalazine (36)
Piperazines (5922)
Alcohols (24)Alkenyls (8)Amides (259)Amines (26)Aryls (85)Bromides (8)Carboxylic Acids (26)Chlorides (21)Esters (33)Ethers (26)Fluorinated Building Blocks (22)Nitriles (14)Nitroes (6)Phenols (1)Sulfamides (12)Sulfones (1)Trifluoromethyls (7)Ureas (5)Isobutylpiperazine (6)Propylpiperazine (10)Furans (4)Indoles (5)Piperidines (4)Pyridines (16)Pyrimidines (23)Spiroes (14)(9H-Fluoren-9-Yl)Methyl Piperazine-1-Carboxylate (7)1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazine (6)1-(Methylsulfonyl)Piperazine (5)1-(Phenylsulfonyl)Piperazine (17)1-(Piperidin-4-Yl)Piperazine (6)1-(Pyridin-3-Yl)Piperazine (13)1-(Pyridin-3-Ylmethyl)Piperazine (6)1-Benzyl 4-(Tert-Butyl) Piperazine-1,4-Dicarboxylate (10)1-Ethylpiperazine (6)1-Isopropylpiperazine (4)1-Methyl-4-(Pyridin-2-Yl)Piperazine (5)1-Methylpiperazin-2-One (6)1-Methylpiperazine (21)10-(3-(Piperazin-1-Yl)Propyl)-10H-Phenothiazine (2)2-(4-(Benzyloxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (10)2-(Piperazin-1-Yl)Ethan-1-Amine (8)2-(Piperazin-1-Yl)Ethan-1-Ol (10)2-(Piperazin-1-Yl)Pyrazine (9)2-(Piperazin-1-Yl)Pyrimidine (11)2-Phenylpiperazine (3)3-(Piperazin-1-Yl)Pyridazine (7)3-Methylpiperazin-2-One (7)4-(Piperazin-1-Yl)Pyrimidine (13)Benzyl 2-Methylpiperazine-1-Carboxylate (7)Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate (6)Benzyl 3-Methylpiperazine-1-Carboxylate (5)Piperazine-2,5-Dione (9)Tert-Butyl 3-Oxopiperazine-1-Carboxylate (7)Tert-Butyl 4-(Pyridin-2-Yl)Piperazine-1-Carboxylate (12)Tert-Butyl 4-Benzylpiperazine-1-Carboxylate (2)Tert-Butyl Piperazine-1-Carboxylate (30)
Piperidines (21719)
Alcohols (126)Aldehydes (17)Alkenyls (18)Amides (433)Amines (176)Aryls (304)Bromides (31)Carboxylic Acids (89)Chlorides (67)Esters (67)Ethers (81)Fluorinated Building Blocks (95)Iodides (4)Ketones (66)Nitriles (54)Nitroes (13)Oximes (5)Phenols (4)Sulfamides (24)Sulfonates (10)Sulfones (6)Sulfonyl Chlorides (4)Trifluoromethyls (8)Bipiperidine (12)Chloropiperidine (6)Dimethylpiperidine (46)Ethynylpiperidine (5)Fluoropiperidine (33)Formylpiperidine (9)Isopropylpiperidine (11)Piperidine-Carboxylate (3)Piperidineacetic (5)Piperidinecarboxylic (6)Piperidinyl-Phenyl-Boronic Acid/Ester (32)Propylpiperidine (8)Tetramethylpiperidine (14)Azetidines (16)Benzimidazoles (18)Benzisoxazoles (4)Benzofurans (5)Indoles (3)Morpholines (30)Oxadiazoles (4)Oxetanes (8)Piperazines (4)Pyrazines (8)Pyridines (15)Pyrimidines (4)Pyrrolidines (36)Spiroes (139)Tetrahydrofurans (9)Tetrahydropyrans (5)Thiophenes (9)Other Aromatic Heterocycles (13)(9H-Fluoren-9-Yl)Methyl Piperidine-1-Carboxylate (16)(E)-N-(3-Oxo-1-Phenyl-3-(Piperidin-1-Yl)Prop-1-En-2-Yl)Benzamide (6)(R)-2-Phenylpiperidine (10)(R)-3-Aminopiperidin-2-One (3)(R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (5)(S)-2-Phenylpiperidine (11)(S)-N-Phenylpiperidine-2-Carboxamide (1)1,3-Dihydrospiro[Indene-2,4'-Piperidine] (5)1,4'-Bipiperidine (8)1-((Benzyloxy)Carbonyl)Piperidine-2-Carboxylic Acid (5)1-((Benzyloxy)Carbonyl)Piperidine-3-Carboxylic Acid (3)1-(Methylsulfonyl)Piperidine (5)1-(Phenylsulfonyl)Piperidine (23)1-(Piperidin-1-Yl)Ethan-1-One (13)1-(Piperidin-4-Yl)Piperazine (6)1-Benzyl 3-Methyl Piperidine-1,3-Dicarboxylate (3)1-Benzyl-N-Methylpiperidin-3-Amine (6)1-Benzylpiperidin-3-One (5)1-Benzylpiperidin-4-Amine (8)1-Benzylpiperidin-4-One (5)1-Isopropylpiperidine (5)1-Methyl-4-Phenylpiperidine (4)1-Methylpiperidin-2-One (3)1-Oxa-8-Azaspiro[4.5]Decane (4)1-Phenylpiperidin-2-One (8)2,2-Dimethylpiperidin-4-One (6)2,2-Dimethylpiperidine (20)2,7-Diazaspiro[3.5]Nonane (7)2,8-Diazaspiro[4.5]Decan-3-One (6)2,8-Diazaspiro[4.5]Decane (5)2-(Piperidin-1-Yl)Ethan-1-Amine (8)2-(Piperidin-1-Yl)Ethan-1-Ol (10)2-(Piperidin-1-Yl)Pyridine (11)2-(Piperidin-1-Yl)Pyrimidine (16)2-(Piperidin-2-Yl)Ethan-1-Ol (8)2-(Piperidin-4-Yl)Ethan-1-Ol (5)2-(Piperidin-4-Yl)Pyridine (5)2-Methylpiperidin-4-One (6)2-Methylpiperidine (12)2-Phenylpiperidine (14)3,3-Difluoropiperidin-4-One (3)3,3-Difluoropiperidine (29)3,3-Dimethylpiperidin-4-One (3)3,3-Dimethylpiperidine (5)3-(1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione (21)3-(Piperidin-1-Yl)Pyridine (5)3-(Piperidin-4-Yl)-1H-Indazole (5)3-(Piperidin-4-Yl)-1H-Indole (8)3-(Piperidin-4-Yl)Pyridine (5)3-Fluoropiperidin-4-One (3)3-Fluoropiperidine (26)3-Methoxypiperidine (7)3-Methylpiperidin-4-One (2)3-Methylpiperidine (10)4,4-Difluoropiperidine (5)4-(1H-Pyrazol-1-Yl)Piperidine (11)4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine (11)4-(Azetidin-1-Yl)Piperidine (6)4-(Piperidin-1-Yl)Pyrimidine (9)4-(Pyrrolidin-1-Yl)Piperidine (6)4-Benzylpiperidine (18)4-Hydrazineylpiperidine (5)4-Hydroxypiperidin-2-One (3)4-Methyl-1-Phenylpiperidine (6)4-Methylenepiperidine (14)4-Oxopiperidine-2-Carboxylic Acid (3)4-Phenylpiperidin-4-Ol (10)5-Hydroxypiperidin-2-One (3)6-Azaspiro[2.5]Octane (10)6-Oxopiperidine-2-Carboxylic Acid (3)7-Azaspiro[3.5]Nonane (7)Azepane (25)Benzyl 3-Hydroxypiperidine-1-Carboxylate (7)Benzyl 4-Oxopiperidine-1-Carboxylate (9)Benzyl Piperidin-4-Ylcarbamate (7)Benzyl Piperidine-1-Carboxylate (50)Benzyl-3-Aminopiperidine-1-Carboxylate (6)Ethyl Piperidine-1-Carboxylate (5)Ethyl Piperidine-2-Carboxylate (8)Ethyl Piperidine-3-Carboxylate (14)Ethyl Piperidine-4-Carboxylate (10)Methyl 4-Oxopiperidine-2-Carboxylate (3)Methyl Piperidine-2-Carboxylate (12)Methyl Piperidine-3-Carboxylate (19)N-Benzylpiperidin-4-Amine (3)N-Methylpiperidin-3-Amine (5)N-Phenylpiperidine-2-Carboxamide (2)Phenyl(Piperidin-1-Yl)Methanone (21)Phenyl(Piperidin-4-Yl)Methanone (21)Piperidin-2-Ylmethanamine (6)Piperidin-2-Ylmethanol (11)Piperidin-3-Amine (17)Piperidin-3-Ol (27)Piperidin-3-One (13)Piperidin-3-Ylmethanamine (5)Piperidin-3-Ylmethanol (15)Piperidin-4-Amine (14)Piperidin-4-Ol (44)Piperidin-4-Ylmethanamine (7)Piperidin-4-Ylmethanol (11)Piperidine-2,4-Dione (5)Piperidine-2,6-Dione (13)Piperidine-2-Carboxylic Acid (26)Piperidine-3-Carboxamide (5)Piperidine-3-Carboxylic Acid (14)Piperidine-4-Carboxylic Acid (12)Quinuclidine (5)Spiro[Benzo[D][1,3]Oxazine-4,4'-Piperidin]-2(1H)-One (5)Spiro[Chromane-2,4'-Piperidin]-4-One (6)Spiro[Indene-2,4'-Piperidin]-1(3H)-One (5)Spiro[Indoline-3,4'-Piperidin]-2-One (18)Spiro[Indoline-3,4'-Piperidine] (5)Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate (4)Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate (3)Tert-Butyl (Piperidin-3-Ylmethyl)Carbamate (5)Tert-Butyl 2-Oxopiperidine-1-Carboxylate (3)Tert-Butyl 3-Bromopiperidine-1-Carboxylate (4)Tert-Butyl 4-Oxopiperidine-1-Carboxylate (14)Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate (12)Tert-Butyl 4-Phenylpiperidine-1-Carboxylate (16)Tert-Butyl Piperidin-3-Ylcarbamate (9)
Purines (2014)
Amides (7)Amines (12)Aryls (4)Chlorides (6)(R)-N-(9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (5)2-(Acetoxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diyl Diacetate (6)2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol (28)2-Chloro-7H-Purine (3)2-Chloro-9H-Purine (5)7H-Purin-2-Amine (6)7H-Purin-6-Amine (9)9-((3As,4R,6Ar)-Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl)-9H-Purine (7)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Amine (28)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Ol (4)9-(Tetrahydrofuran-2-Yl)-9H-Purine (2)9H-Purin-6-Amine (3)
Pyrans (1116)
Aryls (3)Carboxylic Acids (2)Esters (5)Ethers (5)Ketones (7)Chromen-One (1)Thioglucopyranoside (4)(S)-2-Phenylchroman-4-One (16)1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole (17)2,2-Dimethylchromane (5)2-(2-Oxo-2H-Chromen-4-Yl)Acetic Acid (4)2-Oxo-2H-Chromene-3-Carbonitrile (4)2-Oxo-2H-Chromene-3-Carboxylic Acid (15)2H-Chromene (16)3,4-Dihydro-2H-Pyran (11)3,6-Dihydro-2H-Pyran (8)3-Acetyl-2H-Chromen-2-One (3)3-Hydroxy-2-Phenyl-4H-Chromen-4-One (20)4-(Trifluoromethyl)-2H-Chromen-2-One (7)4-Hydroxy-2H-Chromen-2-One (10)4-Methyl-2H-Chromen-2-One (27)5-Fluorochroman-4-One (3)5-Fluorochromane (6)5-Hydroxy-2-Phenyl-4H-Chromen-4-One (35)5-Methoxy-2-Phenyl-4H-Chromen-4-One (9)6-Bromochroman-4-One (6)6-Chlorochroman-4-One (6)6-Chlorochromane (6)6-Fluorochroman-4-One (5)6-Fluorochromane (6)6-Methoxychromane (5)7-(Diethylamino)-2H-Chromen-2-One (9)7-Bromochroman-4-One (4)7-Bromochromane (7)7-Chlorochromane (4)7-Fluorochroman-4-One (5)7-Hydroxy-2H-Chromen-2-One (23)7-Methoxy-2H-Chromen-2-One (12)7-Methoxychroman-4-One (3)8-Bromochroman-4-One (4)8-Bromochromane (6)8-Chlorochromane (5)8-Fluorochromane (5)8-Methylchroman-4-One (4)8-Methylchromane (11)Chroman-2-One (5)Chroman-2-Ylmethanamine (3)Chroman-4-Amine (20)Chroman-4-Ol (4)Chromane-2-Carboxylic Acid (6)Chromane-3-Carboxylic Acid (4)Dihydro-2H-Pyran-2,6(3H)-Dione (5)Ethyl 2-Oxo-2H-Chromene-3-Carboxylate (5)Isochromane (11)Spiro[Chromane-2,4'-Piperidin]-4-One (6)Tetrahydro-2H-Pyran-2-One (14)Tetrahydro-2H-Thiopyran (10)Tetrahydro-4H-Pyran-4-One (12)Thiochroman-4-One (10)
Pyrazines (3412)
Alcohols (6)Aldehydes (4)Alkynyls (6)Amides (17)Amines (19)Aryls (13)Bromides (9)Carboxylic Acids (12)Chlorides (31)Esters (9)Ethers (19)Fluorinated Building Blocks (8)Trifluoromethyls (5)Dibromopyrazine (7)Dichloropyrazine (21)Dihydropyrazine (6)Dimethylpyrazine (30)Ethoxypyrazine (5)Ethylpyrazine (7)Fluoropyrazine (6)Hydroxypyrazine (4)Iodopyrazine (17)Methoxypyrazine (36)Phenylpyrazin (5)Pyrazino (5)Pyrazino-Nitrile (50)Piperidines (8)1,2,3,4-Tetrahydropyrido[2,3-B]Pyrazine (5)1-(Pyrazin-2-Yl)Ethan-1-One (5)1H-Pyrazolo[3,4-B]Pyrazine (5)2,3-Diphenylpyrazine (5)2,5-Dibromopyrazine (4)2,5-Dichloropyrazine (4)2,6-Dibromopyrazine (9)2,6-Dichloropyrazine (14)2-(Piperazin-1-Yl)Pyrazine (9)2-(Trifluoromethyl)Pyrazine (6)2-Bromo-3-Methoxypyrazine (5)2-Bromo-3-Methylpyrazine (5)2-Bromo-5-Chloropyrazine (6)2-Bromo-6-Chloropyrazine (5)2-Bromo-6-Methylpyrazine (5)2-Bromopyrazine (15)2-Chloro-3-Methylpyrazine (7)2-Chloro-6-Methylpyrazine (12)2-Chloropyrazine (24)2-Ethoxypyrazine (3)2-Ethylpyrazine (9)2-Fluoropyrazine (7)2-Iodopyrazine (25)2-Methoxypyrazine (45)2-Methylpyrazine (15)2-Phenylpyrazine (12)3-Chloropyrazin-2-Amine (6)3-Chloropyrazine-2-Carbonitrile (6)4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine (7)4-(Pyrazin-2-Yl)Morpholine (5)5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine (11)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyrazine (15)5,6,7,8-Tetrahydroimidazo[1,5-A]Pyrazine (11)5-Bromopyrazin-2-Amine (13)5-Bromopyrazin-2-Ol (5)5-Chloropyrazin-2-Amine (9)5H-Pyrrolo[2,3-B]Pyrazine (14)6-Bromopyrazin-2-Amine (5)6-Chloropyrazin-2-Amine (11)[1,2,4]Triazolo[1,5-A]Pyrazine (9)[1,2,4]Triazolo[4,3-A]Pyrazine (11)Ethyl Pyrazine-2-Carboxylate (10)Imidazo[1,5-A]Pyrazine (9)Methyl 3-Bromopyrazine-2-Carboxylate (5)Methyl 6-Bromopyrazine-2-Carboxylate (7)Methyl 6-Chloropyrazine-2-Carboxylate (5)Methyl Pyrazine-2-Carboxylate (19)Pyrazin-2-Amine (22)Pyrazin-2-Ol (7)Pyrazin-2-Ylmethanamine (12)Pyrazine-2-Carbaldehyde (17)Pyrazine-2-Carbohydrazide (3)Pyrazine-2-Carbonitrile (15)Pyrazine-2-Carboxamide (10)Pyrazine-2-Carboxylic Acid (33)Pyrazolo[1,5-A]Pyrazine (5)Pyrido[2,3-B]Pyrazine (12)Pyrido[3,4-B]Pyrazine (11)Tert-Butyl Pyrazin-2-Ylcarbamate (8)
Pyrazoles (15811)
Alcohols (42)Aldehydes (41)Amides (46)Amines (159)Aryls (121)Bromides (38)Carboxylic Acids (71)Chlorides (26)Difluoromethyls (11)Esters (29)Ethers (39)Fluorinated Building Blocks (52)Iodides (17)Ketones (13)Nitriles (39)Nitroes (28)Sulfamides (4)Sulfonyl Chlorides (4)Trifluoromethyls (26)Bipyrazole (5)Chloropyrazolo (33)Dichloropyrazolo (11)Dihydropyrazolo (28)Dimethylpyrazolo (6)Ethylpyrazole (7)Fluoropyrazolo (9)Hydroxypyrazolo (10)Methoxypyrazolo (16)Methyl-Pyrazole-Carboxylic Acid (147)Methyl-Pyrazolone (85)Methylpyrazolo (32)Pyrazol-Methanol (1)Pyrazolopyridine-Carboxylic Acid (48)Tetrahydropyrazolo (23)Tetrahydropyrans (4)Thiophenes (11)(1-Methyl-1H-Pyrazol-3-Yl)Methanol (7)(1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid (4)1,3-Dimethyl-1H-Pyrazole (29)1,3-Diphenyl-1H-Pyrazole (5)1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole (6)1,5-Diphenyl-1H-Pyrazole (11)1-(2-Chlorophenyl)-1H-Pyrazole (3)1-(3-Chlorophenyl)-1H-Pyrazole (3)1-(4-Methoxybenzyl)-1H-Pyrazole (5)1-(Azetidin-3-Yl)-1H-Pyrazole (7)1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Pyrazole (9)1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole (6)1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine (9)1-Benzyl-4-Bromo-1H-Pyrazole (5)1-Benzyl-4-Iodo-1H-Pyrazole (5)1-Cyclopentyl-1H-Pyrazole (5)1-Cyclopropyl-1H-Pyrazole (9)1-Methyl-1H-Pyrazol-3-Amine (14)1-Methyl-3-Phenyl-1H-Pyrazole (20)1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole (6)1-Methyl-5-Phenyl-1H-Pyrazole (7)1-Phenyl-1H-Pyrazol-3-Amine (3)1-Phenyl-1H-Pyrazol-3-Ol (3)1-Phenyl-1H-Pyrazol-5-Amine (4)1-Phenyl-1H-Pyrazole-3-Carboxylic Acid (10)1-Phenyl-1H-Pyrazole-4-Carbaldehyde (8)1-Phenyl-1H-Pyrazole-4-Carbonitrile (17)1-Phenyl-1H-Pyrazole-4-Carboxylic Acid (19)1-Phenyl-1H-Pyrazole-5-Carboxylic Acid (3)1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole (5)1-Trityl-1H-Pyrazole (5)1H-Pyrazol-4-Amine (6)1H-Pyrazol-4-Ol (3)1H-Pyrazol-5-Amine (19)1H-Pyrazole-4-Carbaldehyde (30)1H-Pyrazole-4-Carbonitrile (5)1H-Pyrazole-4-Carboxylic Acid (9)1H-Pyrazole-4-Sulfonyl Chloride (8)1H-Pyrazole-5-Carboxamide (3)1H-Pyrazole-5-Carboxylic Acid (10)1H-Pyrazolo[3,4-B]Pyrazine (5)1H-Pyrazolo[3,4-B]Pyridin-5-Amine (3)1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine (5)1H-Pyrazolo[4,3-D]Pyrimidine (5)2,3-Dihydropyrazolo[5,1-B]Oxazole (7)2,4-Dihydro-3H-Pyrazol-3-One (10)2,6-Di(1H-Pyrazol-1-Yl)Pyridine (5)2-(1H-Pyrazol-1-Yl)Pyridine (16)2-(1H-Pyrazol-1-Yl)Pyrimidine (6)2-(1H-Pyrazol-3-Yl)Pyridine (4)2-Phenyl-2,4-Dihydro-3H-Pyrazol-3-One (24)3-(Tert-Butyl)-1-Phenyl-1H-Pyrazole (4)3-Bromo-1-Methyl-1H-Pyrazole (16)3-Bromopyrazolo[1,5-A]Pyridine (6)3-Bromopyrazolo[1,5-A]Pyrimidine (11)3-Chloro-1-Methyl-1H-Pyrazole (7)3-Cyclopropyl-1H-Pyrazole (5)3-Iodo-1-Methyl-1H-Pyrazole (6)3-Iodo-1H-Pyrazolo[3,4-B]Pyridine (4)3-Methyl-1-Phenyl-1H-Pyrazole (23)3-Phenyl-1H-Pyrazol-5-Amine (11)4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine (7)4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine (14)4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyrazine (7)4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine (6)4-(1H-Pyrazol-1-Yl)Benzoic Acid (3)4-(1H-Pyrazol-1-Yl)Piperidine (11)4-Bromo-1-Methyl-1H-Pyrazole (14)4-Bromo-1-Phenyl-1H-Pyrazole (11)4-Bromo-1H-Pyrazolo[3,4-B]Pyridine (4)4-Bromopyrazolo[1,5-A]Pyridine (8)4-Chloro-1H-Pyrazole (10)4-Chloro-1H-Pyrazolo[3,4-B]Pyridine (5)4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (5)4-Iodo-1H-Pyrazole (9)4-Methyl-1-Phenyl-1H-Pyrazole (6)4-Methyl-1H-Pyrazole (10)4-Nitro-1H-Pyrazole (8)4-Phenyl-1H-Pyrazole (17)5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole (8)5-(Difluoromethyl)-1H-Pyrazole (6)5-Bromo-1H-Pyrazole (11)5-Bromo-1H-Pyrazolo[3,4-B]Pyridine (11)5-Bromo-1H-Pyrazolo[3,4-C]Pyridine (5)5-Chloro-1H-Pyrazole (8)5-Chloro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Chloropyrazolo[1,5-A]Pyrimidine (24)5-Cyclopropyl-1H-Pyrazole (6)5-Iodo-1H-Pyrazole (4)5-Nitro-1H-Pyrazole (9)5-Nitro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Phenyl-1H-Pyrazole-3-Carboxylic Acid (15)6,7-Dihydro-5H-Pyrazolo[5,1-B][1,3]Oxazine (12)6-Bromopyrazolo[1,5-A]Pyridine (8)6-Bromopyrazolo[1,5-A]Pyrimidine (7)6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (12)7-Chloropyrazolo[1,5-A]Pyrimidine (8)Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate (3)Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate (13)Ethyl 1H-Pyrazole-4-Carboxylate (11)Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (11)Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate (6)Methyl 1H-Pyrazole-4-Carboxylate (10)Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate (3)Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (16)Pyrazolo[1,5-A]Pyrazine (5)Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid (5)Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid (13)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid (7)Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate (7)Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate (3)
Pyridazines (2784)
Alcohols (8)Amides (20)Amines (10)Aryls (15)Bromides (10)Carboxylic Acids (10)Chlorides (32)Esters (11)Ethers (7)Fluorinated Building Blocks (4)Ketones (4)Nitriles (5)Aminopyridazine (12)Dihydropyridazine (26)Dimethylpyridazine (9)Hexahydropyridazines (10)Morpholines (4)2-Methylpyridazin-3(2H)-One (7)3,6-Dichloropyridazine (20)3-(Piperazin-1-Yl)Pyridazine (7)3-(Trifluoromethyl)Pyridazine (3)3-Bromopyridazine (25)3-Chloro-4-Methylpyridazine (7)3-Chloropyridazine (45)3-Iodopyridazine (5)3-Methoxypyridazine (17)3-Methylpyridazine (6)3-Phenylpyridazine (8)4-Aminopyridazin-3(2H)-One (4)4-Bromopyridazin-3(2H)-One (3)4-Bromopyridazine (5)4-Chloropyridazin-3(2H)-One (4)4-Chloropyridazine (16)4-Methoxypyridazine (8)4-Methylpyridazine (3)6-Chloropyridazin-3(2H)-One (5)6-Chloropyridazin-3-Amine (5)[1,2,4]Triazolo[4,3-B]Pyridazine (10)Ethyl Pyridazine-3-Carboxylate (6)Methyl Pyridazine-3-Carboxylate (7)Pyridazin-3-Amine (18)Pyridazin-3-Ol (3)Pyridazin-4-Amine (10)Pyridazine-3-Carboxylic Acid (7)
Pyridines (71397)
Acyl Chlorides (13)Alcohols (160)Aldehydes (54)Alkenyls (36)Alkynyls (17)Amides (267)Amidines (13)Amines (393)Aryls (178)Bromides (398)Carboxylic Acids (172)Chlorides (372)Difluoromethyls (56)Esters (230)Ethers (238)Fluorinated Building Blocks (296)Hydrazides (17)Hydrazines (27)Iodides (78)Ketones (98)Nitriles (126)Nitroes (61)Oximes (11)Phenols (4)Sulfamides (19)Sulfides (18)Sulfones (14)Sulfonyl Chlorides (5)Thioureas (4)Trifluoromethyls (39)Acetylpyridin (5)Aminopicolinate (8)Aminopyridine (74)Benzyloxypyridine (36)Bipyridine (198)Bromopicolinate (19)Bromopicolinic (4)Bromopicolinic Acid (5)Bromopicolinonitrile (6)Bromopyrido (13)Butylpyridine (5)Chloroisonicotinic Acid (5)Chloronicotinaldehyde (23)Chloronicotinamide (11)Chloronicotinate (45)Chloronicotinic (41)Cyanopicolinate (7)Cyanopicolinic (6)Cyanopyridine (34)Cyclopropoxypyridine (6)Cyclopropylpyridine (30)Dibromopicolinate (4)Dibromopicolinic Acid (3)Dibromopyridine (36)Dichloropicolinate (9)Dichloropicolinonitrile (4)Dichloropyridine (120)Difluoropicolinic Acid (3)Difluoropyridine (58)Dihydropyrido (27)Diiodopyridine (13)Dimethoxypicolinic Acid (5)Dimethoxypyridine (33)Dimethylpyridine (142)Diphenylpyridine (6)Dipyridine (29)Ethoxypicolinic Acid (3)Ethoxypyridine (35)Ethylpyridine (36)Ethynylpicolinate (3)Fluoro-Pyridine--Boronate (79)Fluoropicolinaldehyde (8)Fluoropicolinamide (8)Fluoropicolinate (22)Fluoropyridine (287)Fluoropyrido (3)Formylpyridine (23)Hexahydropyrido (7)Hydrazinylpyridine (22)Hydroxymethylpyridine (26)Hydroxypicolinate (13)Hydroxypicolinic (9)Hydroxypicolinonitrile (7)Imidazopyridine (263)Iodopicolinate (5)Iodopicolinic Acid (4)Iodopyridine (167)Isopropoxypyridine (20)Isopropylpyridine (32)Methoxyisonicotinaldehyde (10)Methoxynicotinaldehyde (18)Methoxypicolinaldehyde (13)Methoxypicolinamide (13)Methoxypicolinate (21)Methoxypicolinic (18)Methoxypicolinic Acid (16)Methoxypicolinimidamide (5)Methoxypicolinonitrile (13)Methoxypyridine (339)Methylisonicotinamide (8)Methylnicotinaldehyde (30)Methylnicotinamide (13)Methylpicolinaldehyde (16)Methylpicolinamide (15)Methylpicolinate (27)Methylpicolinic (23)Methylpicolinonitrile (28)Methylpyrido (13)Nitropyridine (392)Oxopyridin (2)Picolinate (41)Pyridinecarbonitrile (50)Pyridyl-Benzene-Boronic Acid/Ester (16)Pyridyl-Phenyl-Boronate (2)Pyridylmethyl (6)Pyrrolopyridine (4)Terpyridine (32)Tetrachloropyridine (5)Tetrafluoropyridine (21)Tetrahydropyridine (48)Tetrahydropyrido (32)Thiazolopyridine (24)Tribromopyridine (9)Trichloropyridine (17)Trifluoropyridine (8)Trimethylpyridine (5)Azetidines (4)Benzimidazoles (6)Imidazoles (4)Indoles (5)Morpholines (24)Piperazines (16)Piperidines (15)Pyrroles (7)Pyrrolidines (2)Thiadiazoles (7)Thiophenes (19)Thiophenols (6)Triazoles (13)Other Aromatic Heterocycles (2)(2-Chloropyridin-4-Yl)Boronic Acid (6)(3-Bromopyridin-2-Yl)Methanol (7)(3-Chloropyridin-2-Yl)Methanamine (6)(3-Fluoropyridin-2-Yl)Methanamine (5)(3-Methylpyridin-2-Yl)Methanamine (5)(3-Methylpyridin-2-Yl)Methanol (10)(3Ar,8As)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (6)(3As,8Ar)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (7)(4R,5S)-4,5-Diphenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (5)(5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid (4)(5-Bromopyridin-2-Yl)Methanamine (5)(5-Bromopyridin-2-Yl)Methanol (5)(5-Chloropyridin-2-Yl)Methanamine (5)(6-Methylpyridin-2-Yl)Methanamine (6)(6-Methylpyridin-2-Yl)Methanol (5)(6-Phenoxypyridin-3-Yl)Boronic Acid (5)(R)-3-(Pyrrolidin-2-Yl)Pyridine (9)(R)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(R)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (7)(S)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (8)(S)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (6)1,1'-Diphenyl-[4,4'-Bipyridine]-1,1'-Diium (7)1,10-Phenanthrolin-4-Ol (3)1,2,3,4-Tetrahydropyrido[2,3-B]Pyrazine (5)1,2,3,6-Tetrahydropyridine (22)1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One (19)1,3-Dihydro-2H-Pyrrolo[2,3-C]Pyridin-2-One (5)1,3-Dihydro-2H-Pyrrolo[3,2-B]Pyridin-2-One (11)1,4-Di(Pyridin-4-Yl)Benzene (5)1-(5-Bromopyridin-2-Yl)Piperazine (6)1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine (30)1-(Pyridin-2-Yl)Ethan-1-Amine (15)1-(Pyridin-2-Yl)Ethan-1-One (36)1-(Pyridin-2-Yl-L2-Azaneyl)Ethan-1-One (12)1-(Pyridin-3-Yl)Ethan-1-Amine (17)1-(Pyridin-3-Yl)Ethan-1-One (29)1-(Pyridin-3-Yl)Piperazine (13)1-(Pyridin-3-Ylmethyl)Piperazine (6)1-(Pyridin-4-Yl)Ethan-1-Amine (23)1-(Pyridin-4-Yl)Ethan-1-One (14)1-Benzyl-1,2,3,6-Tetrahydropyridine (9)1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine (9)1-Methyl-4-(Pyridin-2-Yl)Piperazine (5)1-Methylpyridin-1-Ium Iodide (5)1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea (8)1H-Imidazo[4,5-B]Pyridine (14)1H-Imidazo[4,5-C]Pyridine (12)1H-Pyrazolo[3,4-B]Pyridin-5-Amine (3)1H-Pyrrolo[2,3-C]Pyridin-7-Ol (3)1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid (4)1H-Pyrrolo[3,2-B]Pyridine-3-Carboxylic Acid (6)2,2':6',2''-Terpyridine (15)2,2-Dimethyl-1-(Pyridin-2-Yl-L2-Azaneyl)Propan-1-One (7)2,3'-Bipyridine (11)2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole (12)2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole (13)2,3,5-Trichloropyridine (13)2,3,6-Trichloropyridine (16)2,3-Dibromopyridine (21)2,3-Dichloropyridine (38)2,3-Difluoropyridine (13)2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine (10)2,3-Dihydro-1H-Pyrrolo[2,3-C]Pyridine (5)2,3-Dihydro-1H-Pyrrolo[3,2-C]Pyridine (7)2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine (6)2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine (5)2,3-Dihydropyridin-2-One (5)2,3-Dimethoxypyridine (7)2,3-Dimethylpyridine (8)2,4,6-Trichloropyridine (5)2,4,6-Triphenylpyridine (7)2,4-Dibromopyridine (5)2,4-Dichloro-6-Methylpyridine (8)2,4-Dichloropyridine (50)2,4-Dimethylpyridine (5)2,5-Dibromopyridine (26)2,5-Dichloropyridine (32)2,5-Difluoropyridine (8)2,6-Bis(4,5-Dihydrooxazol-2-Yl)Pyridine (12)2,6-Di(1H-Pyrazol-1-Yl)Pyridine (5)2,6-Dibromo-3-Fluoropyridine (3)2,6-Dibromopyridin-4-Amine (3)2,6-Dibromopyridine (28)2,6-Dichloro-3-Fluoropyridine (10)2,6-Dichloro-3-Methylpyridine (5)2,6-Dichloro-3-Nitropyridine (6)2,6-Dichloro-4-Iodopyridine (4)2,6-Dichloro-4-Methylpyridine (5)2,6-Dichloronicotinonitrile (8)2,6-Dichloropyridin-3-Amine (11)2,6-Dichloropyridine (49)2,6-Difluoropyridine (29)2,6-Dimethoxypyridine (11)2,6-Dimethylpyridin-4-Ol (4)2,6-Dimethylpyridine (26)2-(1H-Pyrazol-1-Yl)Pyridine (16)2-(1H-Pyrazol-3-Yl)Pyridine (4)2-(2,2,2-Trifluoroethoxy)Pyridine (8)2-(2-Chlorophenyl)Pyridine (3)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-(4-Fluorophenyl)Pyridine (11)2-(6-Benzhydrylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(6-Cyclopropylpyridin-2-Yl)-4,5-Dihydrooxazole (10)2-(Benzyloxy)Pyridine (18)2-(Bromomethyl)Pyridine (27)2-(Chloromethyl)-3-Methylpyridine (12)2-(Chloromethyl)Pyridine (12)2-(Chloromethyl)Pyridine 1-Oxide (4)2-(Difluoromethyl)Pyridine (21)2-(Methylsulfonyl)Pyridine (11)2-(Methylthio)Pyridine (5)2-(P-Tolyl)Pyridine (6)2-(Phenoxymethyl)Pyridine (5)2-(Piperidin-1-Yl)Pyridine (11)2-(Piperidin-4-Yl)Pyridine (5)2-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole (5)2-(Pyridin-2-Yl)Acetonitrile (8)2-(Pyridin-2-Yl)Pyrimidine (8)2-(Pyridin-2-Ylmethyl)-4,5-Dihydrooxazole (14)2-(Pyridin-3-Yl)Acetic Acid (14)2-(Pyridin-3-Yl)Acetonitrile (6)2-(Pyrrolidin-2-Yl)Pyridine (5)2-(Thiophen-2-Yl)Pyridine (5)2-(Trifluoromethoxy)Pyridine (6)2-(Trifluoromethyl)Pyridine (6)2-Aminonicotinonitrile (6)2-Benzylpyridine (12)2-Bromo-3-(Trifluoromethyl)Pyridine (4)2-Bromo-3-Chloropyridine (25)2-Bromo-3-Fluoropyridine (26)2-Bromo-3-Iodopyridine (6)2-Bromo-3-Methoxypyridine (7)2-Bromo-3-Methylpyridine (25)2-Bromo-3-Nitropyridine (5)2-Bromo-4-Chloropyridine (7)2-Bromo-4-Methylpyridine (6)2-Bromo-5-(Trifluoromethyl)Pyridine (6)2-Bromo-5-Chloropyridine (22)2-Bromo-5-Fluoropyridine (33)2-Bromo-5-Methoxypyridine (11)2-Bromo-5-Methylpyridine (19)2-Bromo-5-Nitropyridine (11)2-Bromo-6-(Trifluoromethyl)Pyridine (6)2-Bromo-6-Chloropyridine (23)2-Bromo-6-Fluoropyridine (21)2-Bromo-6-Iodopyridine (5)2-Bromo-6-Methoxypyridine (15)2-Bromo-6-Methylpyridine (17)2-Bromo-6-Phenylpyridine (4)2-Bromonicotinic Acid (5)2-Bromopyridin-3-Amine (10)2-Bromopyridin-3-Ol (7)2-Bromopyridine (10)2-Bromopyridine 1-Oxide (6)2-Chloro-3,6-Dimethylpyridine (4)2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (4)2-Chloro-3-(Trifluoromethyl)Pyridine (12)2-Chloro-3-Fluoropyridin-4-Amine (3)2-Chloro-3-Fluoropyridine (20)2-Chloro-3-Iodopyridin-4-Amine (3)2-Chloro-3-Iodopyridine (13)2-Chloro-3-Methoxypyridine (12)2-Chloro-3-Methylpyridine (17)2-Chloro-3-Nitropyridine (10)2-Chloro-4,6-Dimethylpyridine (7)2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (14)2-Chloro-4-(Trifluoromethyl)Pyridine (9)2-Chloro-4-Ethoxypyridine (5)2-Chloro-4-Fluoropyridine (10)2-Chloro-4-Iodopyridine (19)2-Chloro-4-Methoxypyridine (22)2-Chloro-4-Methylpyridine (31)2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-Chloro-5-(Trifluoromethyl)Pyridine (4)2-Chloro-5-Fluoropyridin-4-Amine (3)2-Chloro-5-Fluoropyridine (16)2-Chloro-5-Iodopyridine (18)2-Chloro-5-Methylpyridine (11)2-Chloro-5-Nitropyridine (8)2-Chloro-6-(Trifluoromethyl)Pyridine (16)2-Chloro-6-Fluoropyridine (14)2-Chloro-6-Iodopyridine (9)2-Chloro-6-Methoxypyridine (24)2-Chloro-6-Methyl-3-Nitropyridine (4)2-Chloro-6-Methylnicotinonitrile (10)2-Chloro-6-Methylpyridine (49)2-Chloroisonicotinaldehyde (19)2-Chloroisonicotinic Acid (17)2-Chloroisonicotinonitrile (7)2-Chloronicotinic Acid (7)2-Chloronicotinonitrile (9)2-Chloropyridin-3-Amine (11)2-Chloropyridin-3-Ol (9)2-Chloropyridin-4-Amine (28)2-Chloropyridine 1-Oxide (10)2-Cyclopropyl-4-Phenylquinoline (12)2-Cyclopropylpyridine (20)2-Ethoxypyridine (20)2-Ethylpyridine (9)2-Ethynylpyridine (31)2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Fluoro-3-Iodopyridine (8)2-Fluoro-3-Methylpyridine (14)2-Fluoro-4-Methylpyridine (6)2-Fluoro-5-Methoxypyridine (4)2-Fluoro-5-Methylpyridine (6)2-Fluoro-6-Methoxypyridine (6)2-Fluoro-6-Methylpyridine (20)2-Fluoropyridine (15)2-Hydrazineylpyridine (32)2-Iodo-6-Methylpyridine (5)2-Iodopyridine (27)2-Isopropoxypyridine (16)2-Isopropylpyridine (14)2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Methoxy-3-(Trifluoromethyl)Pyridine (6)2-Methoxy-4-Methylpyridine (5)2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methoxy-5-(Trifluoromethyl)Pyridine (4)2-Methoxy-5-Methylpyridine (5)2-Methoxy-5-Nitropyridine (8)2-Methoxy-6-Methylpyridine (14)2-Methoxyisonicotinic Acid (13)2-Methoxypyridin-3-Amine (6)2-Methoxypyridine (434)2-Methyl-1,10-Phenanthroline (3)2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methyl-3-Nitropyridine (9)2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (3)2-Methylimidazo[1,2-A]Pyridine (8)2-Methylpyridin-3-Ol (9)2-Methylpyridin-4-Amine (7)2-Methylpyridine 1-Oxide (9)2-Nitropyridine (40)2-Phenoxy-5-(Trifluoromethyl)Pyridine (7)2-Phenylimidazo[1,2-A]Pyridine (12)2-Propoxypyridine (9)2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One (8)3,3'-Bipyridine (7)3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine (5)3,5-Dibromopyridine (12)3,5-Dichloropyridine (16)3,5-Difluoropyridine (12)3,5-Dimethoxypyridine (4)3,5-Dimethylpyridine (8)3,5-Diphenylpyridine (5)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine (3)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (74)3-(Benzyloxy)Pyridine (19)3-(Bromomethyl)Pyridine (18)3-(Chloromethyl)Pyridine (22)3-(Cyclopropylmethyl)Pyridine (6)3-(Difluoromethyl)Pyridine (5)3-(Methylsulfonyl)Pyridine (5)3-(Piperidin-1-Yl)Pyridine (5)3-(Piperidin-4-Yl)Pyridine (5)3-(Pyrrolidin-2-Yl)Pyridine (6)3-(Tert-Butyl)Pyridine (5)3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine (3)3-(Trifluoromethyl)Pyridin-2-Ol (5)3-(Trifluoromethyl)Pyridine (51)3-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Bromo-2-Chloropyridin-4-Amine (3)3-Bromo-2-Chloropyridine (20)3-Bromo-2-Fluoropyridine (21)3-Bromo-2-Methoxypyridine (20)3-Bromo-2-Methylpyridine (27)3-Bromo-4-Methylpyridine (13)3-Bromo-5-Chloropyridine (14)3-Bromo-5-Fluoropyridine (18)3-Bromo-5-Methylpyridine (14)3-Bromo-5-Nitropyridine (10)3-Bromopicolinic Acid (9)3-Bromopicolinonitrile (13)3-Bromopyrazolo[1,5-A]Pyridine (6)3-Bromopyridin-2-Amine (30)3-Bromopyridin-2-Ol (17)3-Bromopyridine 1-Oxide (8)3-Chloro-2-Fluoropyridine (13)3-Chloro-2-Methoxypyridine (16)3-Chloro-2-Methylpyridine (4)3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)3-Chloro-5-Fluoropyridine (10)3-Chloro-5-Methylpyridine (7)3-Chloro-5-Nitropyridine (5)3-Chloroimidazo[1,2-A]Pyridine (3)3-Chloropicolinic Acid (9)3-Chloropicolinonitrile (6)3-Chloropyridin-2-Amine (17)3-Chloropyridin-2-Ol (10)3-Cyclopropylpyridine (28)3-Ethoxypyridine (12)3-Ethylpyridine (11)3-Ethynylpyridine (22)3-Fluoro-2-Methoxypyridine (14)3-Fluoro-2-Methylpyridine (15)3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)3-Fluoropicolinic Acid (6)3-Fluoropicolinonitrile (5)3-Fluoropyridin-2-Amine (12)3-Fluoropyridin-4-Amine (4)3-Hydrazineylpyridine (8)3-Iodo-1H-Pyrazolo[3,4-B]Pyridine (4)3-Iodo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Iodo-1H-Pyrrolo[3,2-C]Pyridine (4)3-Iodopyridin-2-Amine (12)3-Iodopyridin-2-Ol (4)3-Iodopyridin-4-Amine (6)3-Iodopyridin-4-Ol (4)3-Iodopyridine (37)3-Methoxypyridin-2-Amine (5)3-Methoxypyridine (51)3-Methyl-1H-Pyrrolo[2,3-B]Pyridine (5)3-Methyl-2-Phenylpyridine (3)3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)3-Methyl-5-Nitropyridine (4)3-Methylimidazo[1,2-A]Pyridine (3)3-Methylpicolinic Acid (13)3-Methylpyridin-2-Amine (7)3-Methylpyridine (49)3-Methylpyridine 1-Oxide (7)3-Nitropyridin-2-Ol (11)3-Nitropyridin-4-Amine (5)3-Nitropyridine (54)3-Phenoxypyridine (12)4'-Phenyl-2,2':6',2''-Terpyridine (13)4,4'-Bipyridine (10)4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine (7)4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine (14)4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine (5)4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine (10)4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine (10)4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (9)4,6-Dichloropyridin-2-Amine (6)4,6-Dichloropyridin-3-Amine (4)4,7-Diphenyl-1,10-Phenanthroline (4)4-(2,4-Diphenyl-1H-Imidazol-5-Yl)Pyridine (5)4-(Benzyloxy)Pyridine (8)4-(Bromomethyl)Pyridine (8)4-(Pyridin-2-Yl)Morpholine (21)4-(Pyridin-3-Yl)Pyrimidine (5)4-(Pyridin-4-Yl)Morpholine (5)4-(Tert-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)4-(Tert-Butyl)Pyridine (5)4-(Trifluoromethyl)Nicotinic Acid (3)4-(Trifluoromethyl)Pyridine (14)4-Bromo-2-Chloropyridine (29)4-Bromo-2-Fluoropyridine (4)4-Bromo-2-Methoxypyridine (4)4-Bromo-3-Methylpyridine (5)4-Bromopyrazolo[1,5-A]Pyridine (8)4-Bromopyridine (31)4-Chloro-1H-Pyrazolo[4,3-C]Pyridine (7)4-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)4-Chloro-1H-Pyrrolo[3,2-C]Pyridine (10)4-Chloro-2,6-Dimethylpyridine (4)4-Chloro-2-Methoxypyridine (6)4-Chloro-3-Methylpyridine (7)4-Chloronicotinic Acid (4)4-Chloropyridin-2-Amine (6)4-Chloropyridine (31)4-Cyclopropylpyridine (7)4-Ethoxypyridine (7)4-Ethynylpyridine (10)4-Iodopyridine (17)4-Isopropyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (16)4-Methoxypyridine (136)4-Methyl-2,2'-Bipyridine (8)4-Methyl-2-Phenylpyridine (3)4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)4-Methyl-3-Nitropyridine (8)4-Methylnicotinic Acid (5)4-Methylpyridine (24)4-Nitropyridine (11)4-Phenoxypyridine (7)4-Phenyl-1,2,3,6-Tetrahydropyridine (7)4-Phenyl-1,4-Dihydropyridine (10)5,6,7,8-Tetrahydroimidazo[1,2-A]Pyridine (11)5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine (7)5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine (17)5,6-Dichloropyridin-2-Amine (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine (9)5-(Trifluoromethyl)Pyridin-2-Amine (5)5-(Trifluoromethyl)Pyridin-2-Ol (8)5-Benzyl-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (7)5-Bromo-2-Chloro-4-Methylpyridine (5)5-Bromo-2-Chloropyridine (40)5-Bromo-2-Fluoropyridine (22)5-Bromo-2-Iodopyridine (5)5-Bromo-2-Methoxypyridine (29)5-Bromo-2-Methylpyridine (23)5-Bromo-2-Phenylpyridine (3)5-Bromo-4-Methylpyridin-2-Amine (5)5-Bromo-6-Chloropyridin-2-Amine (3)5-Bromonicotinaldehyde (12)5-Bromonicotinic Acid (6)5-Bromonicotinonitrile (6)5-Bromopicolinic Acid (11)5-Bromopicolinonitrile (13)5-Bromopyridin-2-Amine (35)5-Bromopyridin-2-Ol (18)5-Bromopyridin-3-Amine (10)5-Bromopyridin-3-Ol (6)5-Chloro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Chloro-1H-Pyrazolo[4,3-B]Pyridine (6)5-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)5-Chloro-1H-Pyrrolo[3,2-B]Pyridine (6)5-Chloro-2-Fluoropyridine (13)5-Chloro-2-Methoxypyridine (10)5-Chloro-2-Methylpyridine (10)5-Chloroimidazo[1,2-A]Pyridine (3)5-Chloropicolinic Acid (7)5-Chloropicolinonitrile (6)5-Chloropyridin-2-Amine (26)5-Chloropyridin-2-Ol (15)5-Chloropyridin-3-Amine (7)5-Fluoro-2-Methoxypyridine (15)5-Fluoro-2-Methylpyridine (8)5-Fluoropicolinonitrile (5)5-Fluoropyridin-2-Amine (15)5-Iodopyridin-2-Amine (17)5-Iodopyridin-2-Ol (8)5-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (4)5-Methoxypyridin-3-Amine (4)5-Methylimidazo[1,2-A]Pyridine (4)5-Methylpyridin-2-Amine (7)5-Methylpyridin-3-Amine (4)5-Nitronicotinic Acid (5)5-Nitropyridin-2-Amine (6)5-Phenylpicolinic Acid (4)6,7-Dihydro-5H-Cyclopenta[B]Pyridine (18)6,7-Dihydro-5H-Cyclopenta[C]Pyridine (7)6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine (5)6-(Trifluoromethyl)Pyridin-2-Amine (11)6-(Trifluoromethyl)Pyridin-3-Amine (5)6-Bromo-1H-Pyrazolo[4,3-B]Pyridine (4)6-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)6-Bromo-1H-Pyrrolo[3,2-C]Pyridine (5)6-Bromoimidazo[1,2-A]Pyridine (14)6-Bromonicotinaldehyde (10)6-Bromonicotinic Acid (9)6-Bromonicotinonitrile (7)6-Bromopicolinic Acid (5)6-Bromopyrazolo[1,5-A]Pyridine (8)6-Bromopyridin-2-Amine (8)6-Bromopyridin-3-Amine (12)6-Bromopyridin-3-Ol (13)6-Chloro-1H-Pyrazolo[4,3-C]Pyridine (8)6-Chloro-1H-Pyrrolo[3,2-C]Pyridine (11)6-Chloro-3-Nitropyridin-2-Amine (4)6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine (3)6-Chloro-5-Iodopyridin-2-Amine (3)6-Chloroimidazo[1,2-A]Pyridine (4)6-Chloronicotinaldehyde (24)6-Chloronicotinic Acid (4)6-Chloropicolinic Acid (12)6-Chloropicolinonitrile (9)6-Chloropyridin-2-Amine (21)6-Chloropyridin-2-Ol (9)6-Chloropyridin-3-Amine (4)6-Chloropyridine-3-Sulfonyl Chloride (5)6-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (3)6-Fluoropyridin-2-Amine (8)6-Fluoropyridin-3-Amine (4)6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine (3)6-Methoxynicotinaldehyde (4)6-Methoxypicolinic Acid (9)6-Methoxypyridin-2-Amine (14)6-Methoxypyridin-3-Amine (8)6-Methylnicotinic Acid (6)6-Methylnicotinonitrile (7)6-Methylpicolinic Acid (12)6-Methylpicolinonitrile (10)6-Methylpyridin-2-Amine (46)6-Methylpyridin-2-Ol (23)6-Methylpyridin-3-Amine (5)6-Methylpyridin-3-Ol (7)6-Phenoxypyridin-3-Amine (5)6-Phenylnicotinic Acid (8)6-Phenylpicolinic Acid (3)7-Bromo-1H-Pyrrolo[2,3-C]Pyridine (4)7-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)7-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (5)7-Methylimidazo[1,2-A]Pyridine (3)9H-Pyrido[3,4-B]Indole (5)Bis(Pyridin-2-Ylmethyl)Amine (6)Dimethyl Pyridine-2,6-Dicarboxylate (7)Dimethyl(Pyridin-2-Yl)Phosphine Oxide (8)Dimethyl(Pyridin-3-Yl)Phosphine Oxide (7)Ethyl 2-(Pyridin-2-Yl)Acetate (15)Ethyl 2-Methylnicotinate (6)Ethyl 4,6-Dichloronicotinate (4)Ethyl 6-Chloropicolinate (7)Ethyl Isonicotinate (12)Ethyl Nicotinate (25)Ethyl Picolinate (41)Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (11)Furo[3,2-B]Pyridine (7)Furo[3,2-C]Pyridine (7)Imidazo[1,2-A]Pyridin-2-Ylmethanol (4)Imidazo[1,2-A]Pyridine-5-Carboxylic Acid (3)Imidazo[1,2-A]Pyridine-6-Carbonitrile (3)Isonicotinaldehyde (68)Isonicotinamide (12)Isonicotinic Acid (23)Isonicotinohydrazide (6)Isonicotinonitrile (16)Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate (3)Methyl 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate (3)Methyl 2-(Pyridin-2-Yl)Acetate (9)Methyl 2-Chloroisonicotinate (11)Methyl 2-Chloronicotinate (6)Methyl 3-Bromopicolinate (9)Methyl 3-Chloropicolinate (9)Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate (4)Methyl 5-Hydroxypicolinate (5)Methyl 6-Bromonicotinate (6)Methyl 6-Chloropicolinate (11)Methyl 6-Fluoronicotinate (4)Methyl 6-Methoxynicotinate (4)Methyl Isonicotinate (16)Methyl Nicotinate (52)Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate (16)N,N-Dimethylpyridin-2-Amine (10)N,N-Dimethylpyridin-4-Amine (6)N-(Pyridin-2-Yl)Benzamide (9)N-Benzylpyridin-2-Amine (9)N-Methylpicolinamide (10)N-Methylpyridin-2-Amine (47)N-Methylpyridin-3-Amine (15)N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine (5)N-Phenylpicolinamide (8)N-Phenylpyridin-2-Amine (9)Nicotinaldehyde (152)Nicotinamide (61)Nicotinic Acid (53)Nicotinonitrile (82)Oxazolo[4,5-B]Pyridine (7)Oxazolo[5,4-B]Pyridine (5)Phenyl(Pyridin-2-Yl)Methanone (10)Phenyl(Pyridin-3-Yl)Methanone (9)Picolinaldehyde (98)Picolinamide (26)Picolinic Acid (22)Picolinimidamide (11)Picolinohydrazide (5)Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid (5)Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid (13)Pyridin-2-Amine (29)Pyridin-2-Ol (170)Pyridin-2-Ylboronic Acid (9)Pyridin-2-Ylmethanamine (38)Pyridin-2-Ylmethanol (65)Pyridin-3-Amine (21)Pyridin-3-Ol (13)Pyridin-3-Ylboronic Acid (49)Pyridin-3-Ylmethanamine (29)Pyridin-3-Ylmethanol (39)Pyridin-4-Amine (22)Pyridin-4-Ol (16)Pyridin-4-Ylboronic Acid (21)Pyridin-4-Ylmethanamine (12)Pyridin-4-Ylmethanol (16)Pyridine 1-Oxide (32)Pyridine-2,3-Diamine (5)Pyridine-2,6-Diamine (12)Pyridine-2,6-Dicarboxylic Acid (9)Pyridine-2,6-Diol (6)Pyridine-2-Sulfonamide (6)Pyridine-2-Sulfonyl Chloride (9)Pyridine-2-Thiol (8)Pyridine-3-Sulfonic Acid (6)Pyridine-3-Sulfonyl Chloride (25)Pyrido[2,3-B]Pyrazine (12)Pyrido[2,3-D]Pyrimidine (8)Pyrido[3,2-D]Pyrimidine (14)Pyrido[3,4-B]Pyrazine (11)Pyrido[3,4-D]Pyrimidine (10)Tert-Butyl (2-Chloropyridin-4-Yl)Carbamate (4)Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate (7)Tert-Butyl 4-(Pyridin-2-Yl)Piperazine-1-Carboxylate (12)Tert-Butyl Pyridin-2-Ylcarbamate (37)Tert-Butyl Pyridin-3-Ylcarbamate (16)Tert-Butyl Pyridin-4-Ylcarbamate (6)Thiazolo[4,5-B]Pyridine (12)Thiazolo[5,4-B]Pyridine (13)Thiazolo[5,4-C]Pyridine (5)Thieno[2,3-B]Pyridine (22)Thieno[2,3-C]Pyridine (14)Thieno[3,2-B]Pyridine (18)Thieno[3,2-C]Pyridine (13)
Pyrimidines (14900)
Alcohols (63)Aldehydes (11)Alkenyls (10)Alkynyls (7)Amides (119)Amidines (4)Amines (191)Aryls (77)Bromides (71)Carboxylic Acids (46)Chlorides (209)Difluoromethyls (9)Esters (63)Ethers (113)Fluorinated Building Blocks (38)Hydrazines (8)Iodides (15)Ketones (8)Nitriles (15)Nitroes (13)Sulfamides (1)Sulfides (53)Sulfones (7)Trifluoromethyls (6)Bipyrimidine (4)Dibromopyrimidine (15)Methoxypyrimidine (107)Pyrimidinone (2)Tetraoxatetradecan (10)Trichloropyrimidine (11)Azetidines (4)Indoles (7)Morpholines (4)Piperazines (23)Piperidines (4)Pyrrolidines (31)Thiophenols (4)(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (8)(R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (5)1,4,5,6-Tetrahydropyrimidine (4)1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (9)1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (30)1-(Pyrimidin-2-Yl)Ethan-1-One (5)1-(Pyrimidin-4-Yl)Ethan-1-One (6)1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (48)1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine (5)1H-Pyrazolo[4,3-D]Pyrimidine (5)2,4,5-Trichloropyrimidine (6)2,4,6-Trichloropyrimidine (14)2,4,6-Triphenylpyrimidine (9)2,4-Dichloro-6-Methylpyrimidine (7)2,4-Dichloropyrimidin-5-Amine (6)2,4-Dimethoxypyrimidine (13)2,4-Dimethylpyrimidine (7)2-(1H-Pyrazol-1-Yl)Pyrimidine (6)2-(Chloromethyl)Pyrimidine (5)2-(Methylsulfonyl)Pyrimidine (25)2-(Methylthio)Pyrimidin-4-Amine (10)2-(Methylthio)Pyrimidine (19)2-(Piperazin-1-Yl)Pyrimidine (11)2-(Piperidin-1-Yl)Pyrimidine (16)2-(Propylthio)Pyrimidine (5)2-(Pyridin-2-Yl)Pyrimidine (8)2-(Pyrrolidin-1-Yl)Pyrimidine (8)2-(Trifluoromethyl)Pyrimidine (27)2-Aminopyrimidin-4(3H)-One (11)2-Bromopyrimidine (22)2-Chloro-4-(Trifluoromethyl)Pyrimidine (6)2-Chloro-4-Methoxypyrimidine (14)2-Chloro-4-Methylpyrimidine (16)2-Chloro-4-Phenylpyrimidine (7)2-Chloro-5-Fluoropyrimidine (6)2-Chloro-5-Methylpyrimidine (5)2-Chloro-5-Nitropyrimidine (5)2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine (13)2-Chloropyrimidin-4-Amine (22)2-Cyclopropylpyrimidine (10)2-Ethoxypyrimidine (7)2-Ethylpyrimidine (6)2-Fluoropyrimidine (9)2-Hydrazineylpyrimidine (6)2-Iodopyrimidine (8)2-Methoxypyrimidin-4-Amine (6)2-Methoxypyrimidine (59)2-Methylpyrimidin-4-Amine (22)2-Methylpyrimidin-4-Ol (11)2-Phenoxypyrimidine (8)2-Phenylpyrimidin-5-Amine (5)3-Methylpyrimidin-4(3H)-One (6)4,5-Dichloropyrimidine (7)4,6-Dichloro-2-(Methylthio)Pyrimidine (9)4,6-Dichloro-2-Methylpyrimidine (7)4,6-Dichloropyrimidin-2-Amine (9)4,6-Dichloropyrimidine (14)4,6-Diphenylpyrimidine (7)4-(Dimethoxymethyl)Pyrimidine (5)4-(Piperazin-1-Yl)Pyrimidine (13)4-(Piperidin-1-Yl)Pyrimidine (9)4-(Pyridin-3-Yl)Pyrimidine (5)4-(Pyrimidin-2-Yl)Morpholine (9)4-(Pyrimidin-4-Yl)Morpholine (13)4-(Trifluoromethyl)Pyrimidin-2-Amine (6)4-(Trifluoromethyl)Pyrimidine (12)4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (22)4-Bromopyrimidine (24)4-Chloro-2-(Methylthio)Pyrimidine (29)4-Chloro-2-Methoxypyrimidine (12)4-Chloro-2-Phenylpyrimidine (5)4-Chloro-5-Fluoro-2-Methylpyrimidine (5)4-Chloro-5-Iodopyrimidine (6)4-Chloro-5-Methoxypyrimidine (7)4-Chloro-5-Methylpyrimidine (8)4-Chloro-6-Methoxypyrimidine (5)4-Chloropyrimidin-2-Amine (23)4-Chloropyrimidin-5-Amine (7)4-Chloropyrimidine-5-Carbonitrile (6)4-Ethoxypyrimidine (6)4-Fluoropyrimidine (8)4-Iodopyrimidine (9)4-Methoxy-2-Methylpyrimidine (8)4-Methoxypyrimidin-2-Amine (6)4-Methoxypyrimidine (102)4-Methyl-2-(Methylthio)Pyrimidine (7)4-Methylpyrimidin-2-Amine (9)4-Methylpyrimidine (22)4-Phenoxypyrimidine (5)4-Phenylpyrimidin-2-Amine (15)5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine (7)5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine (17)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine (27)5-(Benzyloxy)Pyrimidine (5)5-Benzylpyrimidine (7)5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (4)5-Bromo-2-(Methylthio)Pyrimidine (6)5-Bromo-2-Chloropyrimidine (6)5-Bromo-2-Methylpyrimidine (5)5-Bromo-4-Chloropyrimidine (4)5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine (3)5-Bromopyrimidin-4(3H)-One (3)5-Chloropyrimidin-4(3H)-One (4)5-Chloropyrimidine (8)5-Chloropyrimidine-2,4(1H,3H)-Dione (3)5-Ethylpyrimidine (5)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (6)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (3)5-Fluoropyrimidin-4(3H)-One (3)5-Fluoropyrimidine (11)5-Fluoropyrimidine-2,4(1H,3H)-Dione (3)5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine (4)5-Iodopyrimidine (5)5-Methylpyrimidine (3)5-Phenylpyrimidine (16)5H-Pyrrolo[3,2-D]Pyrimidine (16)6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine (5)6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine (8)6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (12)6-Chloropyrimidin-4-Amine (8)7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine (7)7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine (5)7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (3)[1,2,4]Triazolo[1,5-A]Pyrimidine (14)Ethyl 4-Chloropyrimidine-5-Carboxylate (5)Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate (6)Ethyl Pyrimidine-4-Carboxylate (7)Ethyl Pyrimidine-5-Carboxylate (5)Imidazo[1,2-C]Pyrimidine (6)Methyl Pyrimidine-2-Carboxylate (10)Methyl Pyrimidine-4-Carboxylate (11)Methyl Pyrimidine-5-Carboxylate (5)N,N-Dimethylpyrimidin-2-Amine (10)N-(9-((2R,5S)-5-((Trityloxy)Methyl)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (5)N-Benzyl-9H-Purin-6-Amine (6)N-Cyclopropylpyrimidin-2-Amine (5)N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide (7)N-Methylpyrimidin-2-Amine (10)N-Methylpyrimidin-4-Amine (10)N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine (5)N-Phenylpyrimidin-2-Amine (5)N-Phenylpyrimidin-4-Amine (7)N2,N4-Diphenylpyrimidine-2,4-Diamine (5)Pyrido[2,3-D]Pyrimidine (8)Pyrido[3,2-D]Pyrimidine (14)Pyrido[3,4-D]Pyrimidine (10)Pyrimidin-2-Ol (21)Pyrimidin-2-Ylmethanamine (7)Pyrimidin-2-Ylmethanol (5)Pyrimidin-4-Amine (29)Pyrimidin-4-Ol (25)Pyrimidin-5-Amine (6)Pyrimidin-5-Ol (5)Pyrimidin-5-Ylboronic Acid (9)Pyrimidine-2,4-Diamine (14)Pyrimidine-2-Carbonitrile (14)Pyrimidine-2-Carboxylic Acid (11)Pyrimidine-2-Thiol (6)Pyrimidine-4,6(1H,5H)-Dione (3)Pyrimidine-4-Carbonitrile (9)Pyrimidine-4-Carboxylic Acid (17)Pyrimidine-5-Carbaldehyde (38)Pyrimidine-5-Carbonitrile (6)Pyrimidine-5-Carboxylic Acid (7)Tetrahydropyrimidin-2(1H)-One (6)Thiazolo[5,4-D]Pyrimidine (5)Thieno[2,3-D]Pyrimidine (30)Thieno[3,2-D]Pyrimidine (24)
Pyrroles (4948)
Alcohols (2)Aldehydes (12)Amides (15)Amines (10)Aryls (30)Bromides (5)Carboxylic Acids (28)Chlorides (13)Esters (21)Fluorinated Building Blocks (8)Ketones (16)Nitriles (6)Nitroes (8)Trifluoromethyls (4)Bromopyrrolo (8)Chloropyrrolo (10)Dihydropyrrolo (15)Octahydropyrrolo (6)Pyrrolopyridine (4)Pyrrolopyridine-Methylamine (6)Pyridines (7)Thiophenes (5)(9H-Fluoren-9-Yl)Methyl Pyrrolidine-1-Carboxylate (26)(Z)-3-((1H-Pyrrol-2-Yl)Methylene)Indolin-2-One (8)1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One (19)1,3-Dihydro-2H-Pyrrolo[3,2-B]Pyridin-2-One (11)1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazole (6)1-(Phenylsulfonyl)-1H-Pyrrole (24)1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine (30)1-Benzylpyrrolidin-2-One (17)1-Methyl-1H-Pyrrole (43)1H-Pyrrol-1-Amine (7)1H-Pyrrole-2-Carbaldehyde (21)1H-Pyrrole-2-Carbonitrile (7)1H-Pyrrole-2-Carboxylic Acid (30)1H-Pyrrole-3-Carbaldehyde (9)1H-Pyrrole-3-Carbonitrile (9)1H-Pyrrolo[2,3-B]Pyridin-6-Amine (4)1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid (5)1H-Pyrrolo[2,3-C]Pyridin-7-Ol (3)2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine (10)2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine (6)2-Bromo-1H-Pyrrole (11)2-Methyl-1H-Pyrrole (49)2-Nitro-1H-Pyrrole (5)2-Phenyl-1H-Pyrrole (24)3,6-Di(Thiophen-2-Yl)-2,5-Dihydropyrrolo[3,4-C]Pyrrole-1,4-Dione (17)3-Bromo-1H-Pyrrole (16)3-Bromo-1H-Pyrrolo[2,3-B]Pyridine (7)3-Iodo-1H-Pyrrolo[3,2-C]Pyridine (4)3-Methyl-1H-Pyrrolo[2,3-B]Pyridine (5)3-Phenyl-1H-Pyrrole (4)3-Phenylpyrrolidine (1)4-Bromo-1H-Pyrrolo[2,3-B]Pyridine (9)4-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)4H-Thieno[3,2-B]Pyrrole (6)5-Bromo-1H-Pyrrolo[2,3-B]Pyridine (13)5-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)5-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (4)5H-Pyrrolo[2,3-B]Pyrazine (14)5H-Pyrrolo[3,2-D]Pyrimidine (16)7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine (7)7-Methoxy-1H-Pyrrolo[2,3-C]Pyridine (5)Ethyl 1H-Pyrrole-2-Carboxylate (24)Ethyl 1H-Pyrrole-3-Carboxylate (8)Methyl 1H-Pyrrole-2-Carboxylate (30)Methyl 1H-Pyrrole-3-Carboxylate (5)Methyl 1H-Pyrrolo[2,3-B]Pyridine-6-Carboxylate (3)Pyrrolo[2,1-F][1,2,4]Triazine (14)Tert-Butyl 1H-Pyrrole-1-Carboxylate (8)Tert-Butyl 1H-Pyrrole-2-Carboxylate (3)
Pyrrolidines (14433)
Alcohols (82)Alkenyls (14)Alkynyls (8)Amides (307)Amines (81)Aryls (141)Bromides (25)Carboxylic Acids (25)Chlorides (49)Esters (32)Ethers (56)Fluorinated Building Blocks (38)Hydrazines (3)Ketones (23)Nitriles (11)Nitroes (12)Sulfamides (10)Sulfides (7)Sulfonates (4)Trifluoromethyls (4)Ureas (2)Acetylpyrrolidine (9)Benzylpyrrolidine (31)Bipyrrolidine (8)Bromopyrrolidine (7)Carbamoylpyrrolidine (5)Difluoropyrrolidine (16)Dimethylpyrrolidine (31)Dioxopyrrolidin (131)Ethylpyrrolidine (9)Fluoropyrrolidine (26)Formylpyrrolidine (10)Mercaptopyrrolidine (4)Methoxypyrrolidine (19)Methylenepyrrolidine (2)Methylpyrrolidine (128)Phenoxypyrrolidine (3)Pyrrolidine-Benzene-Boronic Acid/Ester (20)Azetidines (12)Imidazoles (2)Oxetanes (4)Piperidines (36)Pyridines (2)Pyrimidines (31)Spiroes (86)Tetrahydropyrans (6)(3Ar,6As)-Octahydrocyclopenta[C]Pyrrole (5)(9H-Fluoren-9-Yl)Methyl Pyrrolidine-1-Carboxylate (26)(R)-3-(Pyrrolidin-2-Yl)Pyridine (9)(R)-3-Benzylpyrrolidine (6)(S)-N-(((S)-Tetrahydro-2H-Pyran-2-Yl)Methyl)Pyrrolidine-2-Carboxamide (4)(S)-N-(4-(Thiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide (7)(S)-N-Phenethyl-3-(Pyrrolidin-2-Yl)Propanamide (5)1-((Benzyloxy)Carbonyl)Pyrrolidine-3-Carboxylic Acid (6)1-(3-Chlorophenyl)Pyrrolidine (3)1-(Phenylsulfonyl)Pyrrolidine (15)1-(Pyrrolidin-1-Yl)Ethan-1-One (9)1-Benzyl 2-Methyl Pyrrolidine-1,2-Dicarboxylate (7)1-Benzylpyrrolidin-2-One (17)1-Benzylpyrrolidine (26)1-Methylpyrrolidin-2-One (13)1-Phenylpyrrolidin-2-One (18)2,2-Dimethylpyrrolidine (4)2,5-Dioxopyrrolidin-1-Yl ((Benzyloxy)Carbonyl)Glycinate (8)2,5-Dioxopyrrolidin-1-Yl Benzoate (8)2,8-Diazaspiro[4.5]Decan-3-One (6)2-(2-Chlorophenyl)Pyrrolidine (17)2-(2-Fluorophenyl)Pyrrolidine (16)2-(3-Fluorophenyl)Pyrrolidine (5)2-(Methoxymethyl)Pyrrolidine (6)2-(Pyrrolidin-1-Yl)Benzoic Acid (3)2-(Pyrrolidin-1-Yl)Pyridine (11)2-(Pyrrolidin-1-Yl)Pyrimidine (8)2-(Pyrrolidin-2-Yl)Acetic Acid (8)2-(Pyrrolidin-2-Yl)Pyridine (5)2-(Pyrrolidin-3-Yl)Acetic Acid (6)2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One (5)2-Azabicyclo[2.2.1]Heptane (6)2-Methyl-1-Phenyl-1H-Pyrrole (8)2-Methylpyrrolidine (21)3,3-Difluoropyrrolidine (29)3-(Pyrrolidin-2-Yl)Pyridine (6)3-Aminopyrrolidin-2-One (5)3-Bromopyrrolidine (6)3-Hydroxypyrrolidin-2-One (4)3-Phenoxypyrrolidine (5)3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One (1)3-Phenylpyrrolidine (1)4-(Hydroxymethyl)Pyrrolidin-2-One (4)4-(Pyrrolidin-1-Yl)Aniline (3)4-(Pyrrolidin-1-Yl)Piperidine (6)4-Hydroxypyrrolidin-2-One (7)4H-Thieno[3,4-C]Pyrrole-4,6(5H)-Dione (7)5-(Aminomethyl)Pyrrolidin-2-One (3)5-(Hydroxymethyl)Pyrrolidin-2-One (7)5-Azaspiro[2.4]Heptane (13)5-Oxopyrrolidine-2-Carboxylic Acid (4)6-Azaspiro[3.4]Octane (4)Benzyl (S)-Pyrrolidin-3-Ylcarbamate (7)Benzyl 3-Hydroxypyrrolidine-1-Carboxylate (5)Benzyl-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate (9)Benzyl-3-Aminopyrrolidine-1-Carboxylate (7)Ethyl 5-Oxopyrrolidine-2-Carboxylate (3)Hexahydro-1H-Pyrrolizine (12)Methyl 5-Oxopyrrolidine-2-Carboxylate (3)Methyl Prolinate (43)Methyl Pyrrolidine-3-Carboxylate (9)N,N-Dimethylpyrrolidin-3-Amine (7)N-Methylpyrrolidin-3-Amine (6)Octahydrocyclopenta[C]Pyrrole (6)Phenyl(Pyrrolidin-1-Yl)Methanone (12)Proline (13)Pyrrolidin-2-Ylmethanamine (12)Pyrrolidin-2-Ylmethanol (26)Pyrrolidin-3-Ol (59)Pyrrolidin-3-Ylmethanamine (6)Pyrrolidin-3-Ylmethanol (13)Pyrrolidine-2-Carbonitrile (9)Pyrrolidine-2-Carboxamide (12)Pyrrolidine-3-Carbonitrile (6)Pyrrolidine-3-Carboxylic Acid (14)Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate (15)Tert-Butyl 3-((Methylsulfonyl)Oxy)Pyrrolidine-1-Carboxylate (5)Tert-Butyl 3-Hydroxypyrrolidine-1-Carboxylate (20)Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate (6)Tert-Butyl Pyrrolidin-3-Ylcarbamate (12)Tert-Butyl Pyrrolidine-1-Carboxylate (21)
Pyrrolines (1766)
Amides (24)Aryls (14)Bromides (6)Esters (2)1,3-Dihydro-2H-Pyrrolo[2,3-C]Pyridin-2-One (5)1-Phenyl-1H-Pyrrole-2,5-Dione (12)2,3-Dihydro-1H-Pyrrolo[2,3-C]Pyridine (5)2,3-Dihydro-1H-Pyrrolo[3,2-C]Pyridine (7)2,5-Dihydro-1H-Pyrrol-2-One (5)2,5-Dihydro-1H-Pyrrole (13)2-Phenyl-2,5,6,7-Tetrahydropyrrolo[2,1-C][1,2,4]Triazol-4-Ium (6)3,4-Dihydro-2H-Pyrrole (5)3-Bromo-1H-Pyrrole-2,5-Dione (3)5,6-Dihydro-4H-Pyrrolo[1,2-B]Pyrazole (8)6,7-Dihydro-5H-Pyrrolo[1,2-A]Imidazole (9)6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine (5)6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine (8)
Quinazolines (3172)
Alcohols (12)Amides (42)Amines (9)Aryls (7)Bromides (13)Carboxylic Acids (4)Chlorides (20)Esters (5)Ethers (17)Fluorinated Building Blocks (5)Nitroes (4)Dichloroquinazoline (14)Iodoquinazoline (10)Methylquinazoline (45)Nitroquinazoline (20)Trichloroquinazoline (5)2,4-Dichloroquinazoline (19)2-(Trifluoromethyl)Quinazoline (4)2-Bromoquinazoline (4)2-Chloroquinazolin-4(3H)-One (4)2-Cyclopropylquinazoline (5)2-Mercaptoquinazolin-4(3H)-One (3)2-Methylquinazoline (19)4-Chloroquinazoline (39)4-Methylquinazoline (4)5,6,7,8-Tetrahydroquinazoline (8)5-Chloroquinazoline (4)6-Bromoquinazoline (7)7-Bromoquinazolin-4(3H)-One (4)7-Fluoroquinazolin-4(3H)-One (4)7-Methoxy-N-Phenylquinazolin-4-Amine (12)8-Bromoquinazoline (8)8-Chloroquinazoline (5)8-Fluoroquinazoline (4)8-Methoxyquinazoline (3)8-Methylquinazoline (3)Ethyl Quinazoline-2-Carboxylate (4)N-(3-Chlorophenyl)Quinazolin-4-Amine (10)Quinazolin-2-Amine (13)Quinazolin-2-Ol (7)Quinazolin-4-Amine (8)Quinazolin-4-Ol (10)
Quinolines (12117)
Alcohols (79)Aldehydes (23)Alkenyls (10)Amides (33)Amines (79)Aryls (24)Bromides (106)Carboxylic Acids (90)Chlorides (110)Esters (73)Ethers (81)Fluorinated Building Blocks (50)Hydrazines (4)Iodides (12)Ketones (50)Nitriles (19)Nitroes (19)Sulfonyl Chlorides (6)Trifluoromethyls (7)Dihydroquinoline (111)Iodoquinoline (32)Furans (3)Quinuclidines (8)1,2-Dihydroquinoline (5)1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea (6)2,2'-Biquinoline (3)2,3,6,7-Tetrahydro-1H,5H-Pyrido[3,2,1-Ij]Quinoline (7)2-(Quinolin-2-Yl)-4,5-Dihydrooxazole (7)2-Hydroxyquinolin-4(1H)-One (3)2-Phenylquinoline (18)3,4-Dihydroisoquinoline (11)4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid (3)4-Phenoxyquinoline (5)4-Phenylquinoline (9)6-Bromo-3,4-Dihydroquinolin-2(1H)-One (4)7,8-Dihydroquinolin-5(6H)-One (5)7-(Benzyloxy)Quinoline (6)7-Methoxy-3,4-Dihydroquinolin-2(1H)-One (3)N-Phenyl-N-(4-(Quinolin-4-Yloxy)Phenyl)Cyclopropane-1,1-Dicarboxamide (5)N-Phenylquinolin-4-Amine (11)
Quinoxalines (1423)
Alcohols (6)Amides (15)Amines (7)Bromides (9)Carboxylic Acids (5)Chlorides (9)Fluorinated Building Blocks (5)Nitroes (7)Dichloroquinoxaline (8)Dihydroquinoxalin (7)1,2,3,4-Tetrahydroquinoxaline (6)2-Chloroquinoxaline (39)2-Methylquinoxaline (5)2-Phenylquinoxaline (5)3,4-Dihydroquinoxalin-2(1H)-One (7)5-Bromoquinoxaline (6)6-Bromoquinoxaline (9)6-Chloroquinoxaline (3)6-Methoxyquinoxaline (6)Quinoxalin-2-Amine (3)Quinoxalin-2-Ol (4)
Quinuclidines (212)
Alcohols (5)Alkenyls (6)Amines (5)Aryls (2)Esters (3)Ethers (2)Quinolines (8)
Spiroes (4329)
Alcohols (15)Aliphatic Cyclic Hydrocarbons (19)Alkenyls (4)Amides (190)Amines (13)Aryls (36)Bromides (11)Carboxylic Acids (20)Chlorides (3)Esters (18)Fluorinated Building Blocks (9)Ketones (47)Nitriles (2)Aminospiro (4)Azaspiro (240)Bromospiro (11)Diazaspiro (182)Dihydrospiro (18)Dioxaspiro (39)Fluorospiro (4)Oxospiro (22)Triazaspiro (13)1,3-Dihydrospiro[Indene-2,4'-Piperidine] (5)1,4-Dioxaspiro[4.5]Decane (17)2,8-Diazaspiro[4.5]Decane (5)2-Oxa-8-Azaspiro[4.5]Decane (5)3-Phenyloxetane (11)6-Azaspiro[3.4]Octane (4)7-Azaspiro[3.5]Nonane (7)9,9'-Spirobi[Fluorene] (19)Spiro[Cyclopropane-1,3'-Indolin]-2'-One (6)Spiro[Indene-2,4'-Piperidin]-1(3H)-One (5)Spiro[Indoline-3,4'-Piperidine] (5)Azetidines (85)Benzofurans (5)Dioxolanes (23)Epoxides (5)Imidazolidines (4)Imidazolines (4)Indolines (5)Morpholines (33)Oxazolidines (6)Oxetanes (26)Piperazines (14)Piperidines (139)Pyrrolidines (86)Tetrahydrofurans (17)Tetrahydropyrans (24)Other Aliphatic Heterocycles (14)Other Aromatic Heterocycles (11)
Tetrahydrofurans (2310)
Alcohols (11)Amides (19)Amines (7)Anhydrides (3)Aryls (12)Bromides (4)Carboxylic Acids (7)Chlorides (3)Esters (22)Ethers (1)Ketones (6)Hydroxytetrahydrofuran (16)Iodotetrahydrofuran (3)Methoxytetrahydrofuran (11)Oxotetrahydrofuran (26)Piperidines (9)Spiroes (17)(2R,3S)-2-((Benzoyloxy)Methyl)Tetrahydrofuran-3-Yl Benzoate (8)(3Ar,6Ar)-Hexahydrofuro[3,2-B]Furan (5)(3As,6As)-Tetrahydrofuro[3,4-D][1,3]Dioxole (6)(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (8)(R)-N-(9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (5)(Tetrahydrofuran-2-Yl)Methanamine (2)(Tetrahydrofuran-2-Yl)Methanol (6)(Tetrahydrofuran-3-Yl)Methanamine (3)1,3-Dihydrobenzo[C][1,2]Oxaborole (20)1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (9)1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (30)1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (48)1-Oxa-8-Azaspiro[4.5]Decane (4)2-(Acetoxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diyl Diacetate (6)2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3,4-Diol (28)2-Oxa-8-Azaspiro[4.5]Decane (5)2-Oxabicyclo[2.1.1]Hexane (6)3-Aminodihydrofuran-2(3H)-One (4)3-Iodotetrahydrofuran (3)4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (22)4-Fluoro-2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3-Ol (4)4-Hydroxydihydrofuran-2(3H)-One (14)5-(Hydroxymethyl)Dihydrofuran-2(3H)-One (7)5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (4)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One (6)5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione (3)5-Oxotetrahydrofuran-2-Carboxylic Acid (4)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Amine (28)9-(Tetrahydrofuran-2-Yl)-9H-Purin-6-Ol (4)9-(Tetrahydrofuran-2-Yl)-9H-Purine (2)Dihydrofuran-3(2H)-One (8)Tert-Butyl (Tetrahydrofuran-3-Yl)Carbamate (4)Tetrahydrofuran-2-Carboxylic Acid (4)Tetrahydrofuran-3-Amine (6)Tetrahydrofuran-3-Carboxylic Acid (4)Tetrahydrofuran-3-Ol (7)
Tetrahydroisoquinolines (1316)
Amides (7)Amines (3)Aryls (3)Chlorides (4)Tetrahydroisoquinoline-Carboxylic Acid (48)(9H-Fluoren-9-Yl)Methyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate (7)1,2,3,4-Tetrahydroisoquinolin-5-Amine (4)1,2,3,4-Tetrahydroisoquinolin-5-Ol (3)1,2,3,4-Tetrahydroisoquinolin-6-Amine (3)1,2,3,4-Tetrahydroisoquinolin-6-Ol (6)1,2,3,4-Tetrahydroisoquinolin-7-Amine (3)1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid (19)1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (12)1,4-Dihydroisoquinolin-3(2H)-One (5)1-Methyl-1,2,3,4-Tetrahydroisoquinoline (4)2-Methyl-1,2,3,4-Tetrahydroisoquinoline (13)4,4-Dimethyl-1,2,3,4-Tetrahydroisoquinoline (3)5,6,7,8-Tetrahydroisoquinoline (5)5-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)5-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)5-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)5-Methyl-1,2,3,4-Tetrahydroisoquinoline (4)6-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)6-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)6-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)6-Methoxy-1,2,3,4-Tetrahydroisoquinoline (3)6-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)7-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)7-Chloro-1,2,3,4-Tetrahydroisoquinoline (5)7-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)7-Methoxy-1,2,3,4-Tetrahydroisoquinoline (6)7-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)Isoquinoline-1,3(2H,4H)-Dione (7)
Tetrahydropyrans (3405)
Alcohols (36)Aldehydes (6)Alkenyls (7)Amides (15)Amines (3)Aryls (28)Bromides (6)Carboxylic Acids (12)Chlorides (5)Esters (25)Ethers (24)Fluorinated Building Blocks (8)Hydrazines (4)Iodides (4)Ketones (7)Nitriles (9)Sulfides (3)Difluorochroman (16)Azetidines (6)Piperidines (5)Pyrazoles (4)Pyrrolidines (6)Spiroes (24)(1S,4Ar,7Ar)-1-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran (3)(6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (16)(R)-2-Phenoxytetrahydro-2H-Pyran (7)(S)-2-(Phenylthio)Tetrahydro-2H-Pyran (5)(S)-7-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-7,8,9,10-Tetrahydrotetracene-5,12-Dione (5)(S)-N-(((S)-Tetrahydro-2H-Pyran-2-Yl)Methyl)Pyrrolidine-2-Carboxamide (4)1-(Tetrahydro-2H-Pyran-4-Yl)-1H-Pyrazole (6)2-(Phenoxymethyl)Tetrahydro-2H-Pyran (5)2-Phenoxytetrahydro-2H-Pyran (6)2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate (6)4-Phenoxytetrahydro-2H-Pyran (5)9-Bromoanthracene (5)
Tetrahydroquinolines (1454)
Amides (14)Amines (5)Bromides (6)Fluorinated Building Blocks (6)Tetrahydroquinoline-Carboxylic Acid (18)1-Ethyl-1,2,3,4-Tetrahydroquinoline (6)1-Methyl-1,2,3,4-Tetrahydroquinoline (6)2,3-Dihydroquinolin-4(1H)-One (19)2-Methyl-1,2,3,4-Tetrahydroquinoline (3)4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline (3)4-Methyl-1,2,3,4-Tetrahydroquinoline (2)5,6,7,8-Tetrahydroquinoline (17)6-Bromo-1,2,3,4-Tetrahydroquinoline (6)6-Chloro-1,2,3,4-Tetrahydroquinoline (3)6-Fluoro-1,2,3,4-Tetrahydroquinoline (3)7-Fluoro-1,2,3,4-Tetrahydroquinoline (3)Tert-Butyl 3,4-Dihydroquinoline-1(2H)-Carboxylate (11)
Tetrazoles (140)
Aryls (5)Esters (5)1-Phenyl-1H-Tetrazole (6)5-Phenyl-1H-Tetrazole (23)5-Phenyl-2H-Tetrazole (9)
Thiadiazoles (2165)
Amides (11)Amines (24)Aryls (17)Chlorides (4)Esters (4)Ethers (7)Sulfamides (4)Sulfides (7)Pyridines (7)Thiophenols (6)1,2,3-Thiadiazole (8)1,2,4-Thiadiazole (16)1,2,5-Thiadiazole (6)1,3,4-Thiadiazol-2-Amine (9)2-Bromo-1,3,4-Thiadiazole (11)2-Methyl-1,3,4-Thiadiazole (12)2-Phenyl-1,3,4-Thiadiazole (19)4,7-Diphenylbenzo[C][1,2,5]Thiadiazole (6)4-Bromobenzo[C][1,2,5]Thiadiazole (12)Benzo[D][1,2,3]Thiadiazole (7)
Thiazines (67)
Thiazoles (6800)
Alcohols (32)Aldehydes (15)Amides (40)Amines (102)Aryls (98)Bromides (70)Carboxylic Acids (62)Chlorides (29)Esters (70)Ethers (16)Fluorinated Building Blocks (9)Iodides (4)Ketones (19)Nitriles (7)Nitroes (8)Sulfides (8)Acetylthiazole (7)Bromothiazolo (9)Chlorothiazole (32)Chlorothiazolo (18)Cyanothiazole (7)Cyclopropylthiazole (11)Dibromothiazole (7)Dichlorothiazole (8)Dihydrothiazole (14)Dihydrothiazolo (14)Dimethylthiazole (22)Ethylthiazole (8)Formylthiazole (7)Methylthiazole (109)Nitrothiazol (8)Tetrahydrothiazolo (8)Thiazolopyridine (24)Morpholines (5)Thiophenols (4)1-(Thiazol-2-Yl)Ethan-1-One (9)2,4-Dibromothiazole (5)2,4-Dichlorothiazole (4)2,4-Dimethylthiazole (7)2,5-Dibromothiazole (5)2,5-Dimethylthiazole (4)2-(Chloromethyl)Thiazole (5)2-(Methylthio)Thiazole (5)2-(Thiazol-4-Yl)Acetic Acid (9)2-(Trifluoromethyl)Thiazole (11)2-Bromo-4-Methylthiazole (7)2-Bromo-5-Methylthiazole (7)2-Chloro-4-Methylthiazole (5)2-Chloro-5-Methylthiazole (5)2-Chlorothiazole (32)2-Imino-N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-(Thiazol-4-Yl)Acetamide (3)2-Isopropylthiazole (11)2-Methyl-4-Phenylthiazole (6)2-Phenoxythiazole (5)2-Phenylbenzo[D]Thiazole (16)2-Phenylthiazole-4-Carbaldehyde (9)4,5,6,7-Tetrahydrobenzo[D]Thiazole (7)4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine (10)4,5-Dihydrothiazole (8)4-(4-Fluorophenyl)Thiazole (9)4-(Trifluoromethyl)Thiazole (7)4-Bromothiazole (10)4-Cyclopropylthiazole (6)4-Methyl-2-Phenylthiazole (6)4-Methylthiazol-2-Amine (7)4-Methylthiazole (5)4-Phenylthiazol-2-Amine (37)5,6-Dihydrobenzo[D]Thiazol-7(4H)-One (5)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole (7)5-Bromothiazol-2-Amine (6)5-Bromothiazole (8)5-Methyl-4-Phenylthiazole (5)5-Methylthiazol-2-Amine (6)5-Phenylthiazole (20)Ethyl 2-Aminothiazole-4-Carboxylate (6)Ethyl 2-Aminothiazole-5-Carboxylate (5)Ethyl 2-Phenylthiazole-4-Carboxylate (12)Ethyl 2-Phenylthiazole-5-Carboxylate (9)Ethyl Thiazole-2-Carboxylate (7)Ethyl Thiazole-4-Carboxylate (7)Ethyl Thiazole-5-Carboxylate (7)Methyl 2-Aminothiazole-4-Carboxylate (6)Methyl Thiazole-2-Carboxylate (6)Methyl Thiazole-4-Carboxylate (6)N-(Thiazol-2-Yl)Acetamide (9)N-(Thiazol-2-Yl)Benzamide (9)N-Phenylthiazol-2-Amine (9)Tert-Butyl Thiazol-2-Ylcarbamate (22)Thiazol-2-Ylmethanamine (5)Thiazol-2-Ylmethanol (9)Thiazol-5-Amine (6)Thiazole-2-Carbaldehyde (9)Thiazole-2-Carboxylic Acid (9)Thiazole-4-Carboxylic Acid (5)Thiazole-5-Carbaldehyde (19)Thiazole-5-Carbonitrile (7)Thiazole-5-Carboxylic Acid (10)Thiazolo[4,5-B]Pyridine (12)Thiazolo[5,4-B]Pyridine (13)Thiazolo[5,4-C]Pyridine (5)Thiazolo[5,4-D]Pyrimidine (5)
Thiazolidines (1287)
Amides (16)Aryls (8)Carboxylic Acids (10)Thioesters (8)Thioxothiazolidin (21)(E)-5-Benzylidenethiazolidine-2,4-Dione (6)1,2,3-Oxathiazolidine 2,2-Dioxide (14)2-Thioxothiazolidin-4-One (6)Thiazolidine (62)
Thiomorpholines (446)
Sulfones (8)Thiomorpholine (10)Thiomorpholine 1,1-Dioxide (6)
Thiophenes (1942)
Acetylthiophene (5)Aminothiophene (23)Bromothieno (29)Chlorothieno (41)Chlorothiophene (60)Cyanothiophene (5)Dibromothieno (5)Dibromothiophene (17)Dichlorothieno (10)Dichlorothiophene (13)Dihydrothieno (24)Dihydrothiophene (1)Dihydroxythiophene (7)Dimethylthieno (10)Dimethylthiophene (21)Dithiophene (39)Fluorothiophene (18)Formylthiophene (16)Hydroxythiophene (7)Iodothieno (6)Iodothiophene (13)Methylthieno (26)Methylthiophene (28)Nitrothiophene (27)Terthiophene (10)Tetrahydrothieno (17)Thiophenecarboxaldehyde (10)Thiphen-Amine-Hydrochloride (53)Trithiophene (5)(9H-Fluoren-9-Yl)Methyl (2-(Thiophen-2-Yl)Ethyl)Carbamate (5)1-(Thiophen-2-Yl)Ethan-1-One (17)2,2'-Bithiophene (24)2,2':5',2''-Terthiophene (9)2,3-Dihydrothieno[3,4-B][1,4]Dioxine (9)2,5-Dibromothiophene (18)2,5-Diphenylthiophene (5)2-(Thiophen-2-Yl)Pyridine (5)2-(Trifluoromethyl)Thiophene (10)2-Chlorothiophene (20)2-Ethynylthiophene (8)2-Iodothiophene (14)2-Methoxythiophene (7)2-Nitrothiophene (20)3-Bromothiophene (6)3-Chlorothiophene (17)3-Fluorothiophene (6)3-Methoxythiophene (9)3-Methylthiophene (14)3-Nitrothiophene (6)3-Phenylthiophene (13)4,4,5,5-Tetramethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborolane (23)4,4,5,5-Tetramethyl-2-(Thiophen-3-Yl)-1,3,2-Dioxaborolane (10)4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine (10)4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (9)4,7-Di(Thiophen-2-Yl)Benzo[C][1,2,5]Thiadiazole (8)4,8-Di(Thiophen-2-Yl)Benzo[1,2-B:4,5-B']Dithiophene (8)4-Phenyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine (5)4H-Cyclopenta[2,1-B:3,4-B']Dithiophene (8)4H-Thieno[3,2-B]Pyrrole (6)4H-Thieno[3,4-C]Pyrrole-4,6(5H)-Dione (7)5,6-Dihydro-4H-Cyclopenta[B]Thiophene (7)5-(Thiophen-2-Yl)Isoxazole (5)5-Benzyl-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine (7)5-Phenylthiophen-2-Amine (5)Benzo[1,2-B:4,5-B']Dithiophene (7)Dibenzo[B,D]Thiophene (22)Dihydrothiophen-3(2H)-One (4)Dithieno[3,2-B:2',3'-D]Thiophene (5)Ethyl Thiophene-2-Carboxylate (19)Ethyl Thiophene-3-Carboxylate (11)Methyl Thiophene-3-Carboxylate (35)N,N-Diphenyl-4-(Thiophen-2-Yl)Aniline (5)Phenyl(Thiophen-2-Yl)Methanone (6)Thieno[2,3-B]Pyridine (22)Thieno[2,3-C]Pyridine (14)Thieno[2,3-D]Pyrimidine (30)Thieno[3,2-B]Pyridine (18)Thieno[3,2-B]Thiophene (17)Thieno[3,2-C]Pyridine (13)Thieno[3,2-D]Pyrimidine (24)Thieno[3,4-B]Thiophene (5)Thiophen-2-Ylboronic Acid (20)Thiophen-2-Ylmethanol (11)Thiophen-3-Amine (18)Thiophen-3-Ol (6)Thiophene-2-Carbaldehyde (43)Thiophene-2-Carbonitrile (23)Thiophene-3-Carbaldehyde (17)Thiophene-3-Carbonitrile (13)Thiophene-3-Carboxamide (5)Thiophene-3-Carboxylic Acid (8)
Triazines (1408)
Amides (11)Amines (13)Aryls (12)Chlorides (13)1,2,4-Triazine (10)1,3,5-Triazin-2-Amine (3)2,4,6-Triphenoxy-1,3,5-Triazine (4)2,4,6-Triphenyl-1,3,5-Triazine (24)2,4-Diphenyl-1,3,5-Triazine (6)2-Chloro-1,3,5-Triazine (10)2-Methoxy-1,3,5-Triazine (10)2-Phenyl-1,3,5-Triazine (6)N2,N4,N6-Triphenyl-1,3,5-Triazine-2,4,6-Triamine (4)Pyrrolo[2,1-F][1,2,4]Triazine (14)
Triazoles (7841)
Amides (8)Amines (21)Aryls (24)Carboxylic Acids (10)Esters (9)Ethers (5)Hydrazines (3)Sulfides (3)Pyridines (13)Thiophenols (8)(5As,10Br)-2-Phenyl-2,5A,6,10B-Tetrahydro-4H-Indeno[2,1-B][1,2,4]Triazolo[4,3-D][1,4]Oxazin-11-Ium (6)1-(Phenylsulfonyl)-1H-1,2,4-Triazole (6)1-Benzyl-1H-1,2,3-Triazole (8)1-Benzyl-1H-1,2,4-Triazole (6)1-Methyl-1H-1,2,3-Triazole (9)1-Methyl-1H-1,2,4-Triazole (17)1-Methyl-1H-Benzo[D][1,2,3]Triazole (10)1-Phenyl-1H-1,2,3-Triazole (7)1-Phenyl-1H-1,2,4-Triazole (20)1H-1,2,4-Triazol-3-Amine (6)1H-1,2,4-Triazol-5-Amine (5)2-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)2-Phenyl-2,5,6,7-Tetrahydropyrrolo[2,1-C][1,2,4]Triazol-4-Ium (6)2-Phenyl-2H-1,2,3-Triazole (7)2-Phenyl-2H-Benzo[D][1,2,3]Triazole (8)2H-1,2,3-Triazole (7)4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazole (7)4-Phenyl-4H-1,2,4-Triazole (6)4-Phenyl-6H-Thieno[3,2-F][1,2,4]Triazolo[4,3-A][1,4]Diazepine (5)4H-1,2,4-Triazole (12)5-Bromo-1H-1,2,4-Triazole (6)5-Bromo-1H-Benzo[D][1,2,3]Triazole (5)5-Fluoro-1H-Benzo[D][1,2,3]Triazole (4)6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (12)6-Bromo-[1,2,4]Triazolo[4,3-A]Pyridine (8)8-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)[1,2,4]Triazolo[1,5-A]Pyrazine (9)[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine (17)[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylmethanamine (5)Ethyl 1H-1,2,4-Triazole-3-Carboxylate (3)
Other Aliphatic Heterocycles (6226)
Alcohols (39)Alkenyls (19)Amides (102)Amines (17)Anhydrides (10)Aryls (55)Carboxylic Acids (12)Chlorides (3)Esters (69)Ethers (5)Fluorinated Building Blocks (5)Ketones (59)Sulfamides (11)Sulfides (8)Sulfones (9)Diazepane (6)Epoxides (11)Spiroes (14)1,3-Dioxane (20)1,4-Diazepane (12)3-Azabicyclo[3.1.0]Hexane (14)
Other Aromatic Heterocycles (37701)
Alcohols (107)Aldehydes (40)Alkenyls (5)Amides (176)Amines (129)Anhydrides (33)Aryls (107)Bromides (91)Carboxylic Acids (64)Chlorides (147)Esters (141)Ethers (47)Fluorinated Building Blocks (46)Iodides (28)Ketones (130)Nitriles (31)Nitroes (22)Sulfamides (17)Sulfides (8)Sulfones (5)Trifluoromethyls (18)Phenothiazine (10)Piperidines (13)Pyridines (2)Spiroes (11)Indolizine (16)Phenazine (8)
NHCs
Achiral NHCs Catalysts (35)
Achiral NHCs Ligands (111)
Chiral NHCs Catalysts (138)
Chiral NHCs Ligands (84)
Organic Building Blocks
Acyl Chlorides (3031)
Aliphatic Chain Hydrocarbons (24)Aliphatic Cyclic Hydrocarbons (10)Alkenyls (7)Amides (13)Aryls (28)Bromides (5)Chlorides (88)Esters (22)Pyridines (13)2-Chlorobenzoyl Chloride (13)2-Phenoxyacetyl Chloride (3)2-Phenylacetyl Chloride (9)
Alcohols (45477)
Aldehydes (19)Aliphatic Chain Hydrocarbons (390)Aliphatic Cyclic Hydrocarbons (117)Alkenyls (101)Alkynyls (34)Amides (364)Amines (287)Aryls (626)Azetidines (18)Benzimidazoles (11)Benzodioxans (8)Benzofurans (18)Benzothiazoles (6)Bromides (147)Carboxylic Acid Salts (16)Carboxylic Acids (162)Chlorides (150)Difluoromethyls (10)Dioxolanes (4)Esters (236)Ethers (224)Fluorinated Building Blocks (168)Furans (8)Hydrazides (5)Hydrazines (5)Imidazoles (27)Indazoles (17)Indoles (25)Indolines (13)Iodides (16)Isoquinolines (4)Isoxazoles (8)Ketones (62)Morpholines (23)Nitriles (44)Nitroes (42)Oxazoles (9)Oxazolidines (6)Oxetanes (24)Phenols (15)Piperazines (24)Piperidines (126)Pyrazines (6)Pyrazoles (42)Pyridazines (8)Pyridines (160)Pyrimidines (63)Pyrroles (2)Pyrrolidines (82)Quinazolines (12)Quinolines (79)Quinoxalines (6)Quinuclidines (5)Spiroes (15)Sulfamides (27)Sulfides (27)Sulfones (7)Tetrahydrofurans (11)Tetrahydropyrans (36)Thiazoles (32)Thiols (5)Thiophenes (23)Trifluoromethyls (71)Ureas (5)Other Aliphatic Heterocycles (39)Other Aromatic Heterocycles (107)Amino-Propanol (6)Cyclopropylethanol (6)Diethanol (23)Dihydroxybenzylidene (4)Dihydroxynaphthalene (7)Dihydroxypropanoate (7)Dihydroxyterephthalic Acid (3)Hydroxyacetamide (1)Hydroxyacetimidamide (3)Hydroxyadamantan (4)Hydroxyazetidine (7)Hydroxybenzyl (16)Hydroxybenzylidene (5)Hydroxybicyclo (7)Hydroxybutan (4)Hydroxybutanoate (34)Hydroxybutanoic (30)Hydroxycarbamimidoyl (2)Hydroxycinnamic Acid (2)Hydroxycyclobutyl (3)Hydroxycyclohexyl (7)Hydroxycyclopentyl (1)Hydroxydiphenylmethyl (1)Hydroxyethoxy (22)Hydroxyhexanoate (8)Hydroxyhexanoic (6)Hydroxyimino (11)Hydroxyisonicotinaldehyde (7)Hydroxyisonicotinate (5)Hydroxyisonicotinic (5)Hydroxyisonicotinic Acid (4)Hydroxymethyl-Phenyl-Boronic-Acid (32)Hydroxynaphthalene (27)Hydroxynicotinaldehyde (7)Hydroxynicotinate (13)Hydroxynicotinonitrile (6)Hydroxyoctadec (1)Hydroxyoctadecanoic (7)Hydroxypentanoate (6)Hydroxypropanoic (35)Pentahydroxyhexanal (7)Propanediol (9)Pyrazol-Methanol (1)Tetrahydroxy (20)Tetrahydroxyhexanal (9)Tetrahydroxypentanal (5)Trihydroxy (237)(1-Methyl-1H-Pyrazol-3-Yl)Methanol (7)(1-Phenylcyclopropyl)Methanol (3)(1H-Benzo[D]Imidazol-2-Yl)Methanol (14)(1H-Indol-2-Yl)Methanol (8)(2-(Trifluoromethyl)Phenyl)Methanol (10)(2-Bromo-6-Fluorophenyl)Methanol (4)(2-Bromophenyl)Methanol (39)(2-Chlorophenyl)Methanol (40)(2-Fluorophenyl)Methanol (60)(2-Iodophenyl)Methanol (12)(2-Nitrophenyl)Methanol (29)(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol (7)(3-(Trifluoromethoxy)Phenyl)Methanol (4)(3-(Trifluoromethyl)Phenyl)Methanol (22)(3-Chlorophenyl)Methanol (38)(3-Fluorophenyl)Methanol (58)(3-Iodophenyl)Methanol (13)(3-Methylpyridin-2-Yl)Methanol (10)(3-Nitrophenyl)Methanol (31)(3-Phenoxyphenyl)Methanol (3)(3-Phenylisoxazol-5-Yl)Methanol (7)(4-Fluorophenyl)Methanol (29)(4-Nitrophenyl)Methanol (17)(6-Methylpyridin-2-Yl)Methanol (5)(Tetrahydrofuran-2-Yl)Methanol (6)1,2-Diphenylethan-1-Ol (8)1-Phenyl-1H-Pyrazol-3-Ol (3)1-Phenylethan-1-Ol (102)2,2,2-Trifluoro-1-Phenylethan-1-Ol (27)2-(1H-Indol-3-Yl)Ethan-1-Ol (10)2-(2-Chlorophenyl)Ethan-1-Ol (8)2-(Piperazin-1-Yl)Ethan-1-Ol (10)2-(Piperidin-1-Yl)Ethan-1-Ol (10)2-(Piperidin-2-Yl)Ethan-1-Ol (8)2-(Piperidin-4-Yl)Ethan-1-Ol (5)2-Amino-2-(2-Fluorophenyl)Ethan-1-Ol (7)2-Amino-2-(Anthracen-9-Yl)Ethan-1-Ol (4)2-Amino-2-Phenylethan-1-Ol (196)2-Hydroxy-1,2-Diphenylethan-1-One (3)2-Hydroxy-1-Phenylethan-1-One (8)2-Hydroxyethyl Benzoate (3)2-Phenoxyethan-1-Ol (14)2-Phenylethan-1-Ol (78)2-Phenylpropan-2-Ol (21)3-Phenylpropan-1-Ol (24)4-Fluoro-2-(Hydroxymethyl)-5-(9H-Purin-9-Yl)Tetrahydrofuran-3-Ol (4)4-Phenylpiperidin-4-Ol (10)Azetidin-2-Ylmethanol (7)Azetidin-3-Ol (11)Benzyl 3-(Hydroxymethyl)Piperazine-1-Carboxylate (6)Benzyl-2-(Hydroxymethyl)Pyrrolidine-1-Carboxylate (9)Bicyclo[1.1.1]Pentan-1-Ylmethanol (3)Cyclobutanol (46)Cyclobutylmethanol (15)Cyclohexanol (70)Cyclohexylmethanol (31)Cyclopentanol (51)Diphenylmethanol (20)Isoxazol-3-Ylmethanol (3)Isoxazol-5-Ylmethanol (5)M-Tolylmethanol (34)Morpholin-2-Ylmethanol (12)Morpholin-3-Ylmethanol (14)Naphthalen-1-Ylmethanol (8)O-Tolylmethanol (35)Oxiran-2-Ylmethanol (3)Piperidin-2-Ylmethanol (11)Piperidin-3-Ol (27)Piperidin-3-Ylmethanol (15)Piperidin-4-Ylmethanol (11)Pyridin-2-Ylmethanol (65)Pyridin-3-Ylmethanol (39)Pyridin-4-Ylmethanol (16)Pyrimidin-2-Ylmethanol (5)Pyrrolidin-2-Ylmethanol (26)Pyrrolidin-3-Ylmethanol (13)Quinazolin-2-Ol (7)Tert-Butyl 3-(Hydroxymethyl)-1H-Indole-1-Carboxylate (10)Thiazol-2-Ylmethanol (9)Thiophen-2-Ylmethanol (11)Triphenylmethanol (13)
Aldehydes (18929)
Alcohols (19)Aliphatic Chain Hydrocarbons (55)Aliphatic Cyclic Hydrocarbons (12)Alkenyls (29)Alkynyls (6)Amides (56)Amines (29)Aryls (346)Benzimidazoles (5)Benzofurans (4)Benzothiazoles (5)Bromides (78)Carboxylic Acids (18)Chlorides (88)Esters (47)Ethers (130)Fluorinated Building Blocks (79)Furans (15)Imidazoles (21)Indazoles (9)Indoles (21)Isoxazoles (9)Ketones (19)Morpholines (9)Nitriles (12)Nitroes (22)Phenols (13)Piperidines (17)Pyrazines (4)Pyrazoles (41)Pyridines (54)Pyrimidines (11)Pyrroles (12)Quinolines (23)Sulfamides (6)Sulfides (8)Tetrahydropyrans (6)Thiazoles (15)Thiophenes (13)Trifluoromethyls (10)Other Aromatic Heterocycles (40)Aminonicotinaldehyde (5)Carboxyaldehyde (1091)Dicarbaldehyde (37)Formylisonicotinate (7)Tetracarbaldehyde (8)Tricarbaldehyde (10)1-Methyl-1H-Indole-3-Carbaldehyde (9)1-Naphthaldehyde (23)1-Phenyl-1H-Pyrazole-4-Carbaldehyde (8)1H-Benzo[D]Imidazole-2-Carbaldehyde (5)1H-Indazole-3-Carbaldehyde (19)1H-Indole-2-Carbaldehyde (20)1H-Pyrazole-4-Carbaldehyde (30)1H-Pyrrole-2-Carbaldehyde (21)1H-Pyrrole-3-Carbaldehyde (9)1H-Pyrrolo[2,3-B]Pyridine-3-Carbaldehyde (14)1H-Pyrrolo[2,3-B]Pyridine-5-Carbaldehyde (5)2,3-Dichlorobenzaldehyde (7)2,3-Difluorobenzaldehyde (18)2,4-Dichlorobenzaldehyde (8)2,4-Difluorobenzaldehyde (19)2,6-Dibromobenzaldehyde (4)2,6-Difluorobenzaldehyde (25)2-(Benzyloxy)Benzaldehyde (13)2-(Phenylethynyl)Benzaldehyde (9)2-(Trifluoromethoxy)Benzaldehyde (7)2-(Trifluoromethyl)Benzaldehyde (27)2-Bromo-3-Hydroxybenzaldehyde (4)2-Bromo-3-Methoxybenzaldehyde (4)2-Bromo-6-Fluorobenzaldehyde (15)2-Chloro-3-Hydroxybenzaldehyde (4)2-Chloro-3-Methoxybenzaldehyde (7)2-Chloro-4-Fluorobenzaldehyde (10)2-Fluoro-3-Methylbenzaldehyde (8)2-Fluorobenzaldehyde (175)2-Hydroxy-3-Iodobenzaldehyde (3)2-Iodobenzaldehyde (17)2-Methyl-1H-Indole-3-Carbaldehyde (3)2-Naphthaldehyde (12)2-Nitrobenzaldehyde (53)2-Oxo-2-Phenylacetaldehyde (12)2-Phenylacetaldehyde (20)3-(Benzyloxy)Benzaldehyde (13)3-(Trifluoromethoxy)Benzaldehyde (10)3-(Trifluoromethyl)Benzaldehyde (31)3-Bromo-2-Chlorobenzaldehyde (4)3-Bromo-2-Fluorobenzaldehyde (9)3-Bromo-2-Hydroxybenzaldehyde (10)3-Bromo-4-Fluorobenzaldehyde (7)3-Bromo-4-Hydroxybenzaldehyde (9)3-Bromo-4-Methoxybenzaldehyde (9)3-Chloro-2-Fluorobenzaldehyde (9)3-Chloro-2-Hydroxybenzaldehyde (5)3-Chloro-4-Methoxybenzaldehyde (7)3-Chlorobenzaldehyde (106)3-Fluorobenzaldehyde (137)3-Iodobenzaldehyde (28)3-Methoxy-2-Nitrobenzaldehyde (3)3-Nitrobenzaldehyde (49)3-Phenoxybenzaldehyde (6)4-(1H-Imidazol-1-Yl)Benzaldehyde (7)4-(Benzyloxy)Benzaldehyde (23)4-Fluorobenzaldehyde (78)4-Hydroxy-3-Nitrobenzaldehyde (5)4-Morpholinobenzaldehyde (8)4-Nitrobenzaldehyde (18)4-Phenoxybenzaldehyde (12)5-Phenylfuran-2-Carbaldehyde (9)6-Methoxynicotinaldehyde (4)[1,1'-Biphenyl]-3-Carbaldehyde (20)[1,1'-Biphenyl]-4-Carbaldehyde (31)Benzo[B]Thiophene-2-Carbaldehyde (7)Benzo[B]Thiophene-3-Carbaldehyde (6)Benzo[D][1,3]Dioxole-5-Carbaldehyde (6)Benzofuran-2-Carbaldehyde (5)Furan-2-Carbaldehyde (21)Imidazo[1,2-A]Pyridine-2-Carbaldehyde (8)Imidazo[1,2-A]Pyridine-3-Carbaldehyde (9)Isonicotinaldehyde (68)Methyl 3-Formylbenzoate (23)Nicotinaldehyde (152)Picolinaldehyde (98)Pyrazine-2-Carbaldehyde (17)Pyrimidine-5-Carbaldehyde (38)Thiazole-2-Carbaldehyde (9)Thiazole-5-Carbaldehyde (19)Thiophene-2-Carbaldehyde (43)Thiophene-3-Carbaldehyde (17)
Aliphatic Chain Hydrocarbons (13485)
Acyl Chlorides (24)Alcohols (390)Aldehydes (55)Alkenyls (380)Alkynyls (23)Amides (455)Amidines (21)Amines (304)Anhydrides (11)Bromides (148)Carboxylic Acid Salts (58)Carboxylic Acids (153)Chlorides (137)Difluoromethyls (13)Epoxides (7)Esters (447)Ethers (199)Fluorinated Building Blocks (167)Guanidines (18)Hydrazides (48)Hydrazines (60)Hydroxylamines (11)Iodides (36)Ketones (182)Nitriles (92)Nitroes (7)Sulfamides (37)Sulfides (28)Sulfonates (4)Sulfones (18)Sulfonyl Chlorides (19)Thioesters (4)Thiols (27)Thioureas (19)Trifluoromethyls (67)Ureas (28)Acetylthio (7)Azanonadecan (7)Azanylylidene (1)Azapentadecan (10)Azatridecan (4)Butyloctyl (4)Carbonylbis (1)Diazirine (13)Didodecyl (7)Diethyl (72)Dihydroxypropan (5)Diisobutyl (2)Diisopropyl (26)Dimethoxy (297)Dimethyladamantane (13)Dimethylalkanes (7)Dioctyl (1)Dioxide (442)Ethoxy (702)Ethoxyethoxy (5)Ethoxyethyl (15)Ethoxymethyl (11)Ethoxymethylene (1)Isopropylidenebis (2)Isopropylsulfonyl (10)Methoxybut (2)Methoxyethoxy (64)Methoxyethyl (65)Methoxyisonicotinic (11)Methoxymethoxy (23)Methoxymethyl (117)Methoxynicotinic (26)Methoxynicotinic Acid (20)Methoxypropan (24)Methoxypropoxy (8)Methoxypropyl (10)Methoxytetrahydro (14)Methyladamantan (4)Methylisonicotinic (13)Oxoethoxy (1)Oxopropane (10)Oxopropyl (32)Pentyloxy (7)Tetramethoxy (6)Trimethoxy (15)Yldisulfanyl (7)
Aliphatic Cyclic Hydrocarbons (11865)
Acyl Chlorides (10)Alcohols (117)Aldehydes (12)Alkenyls (57)Amides (132)Amines (135)Aryls (10)Bromides (31)Carboxylic Acids (65)Chlorides (19)Esters (109)Ethers (32)Fluorinated Building Blocks (56)Hydrazides (5)Hydrazines (11)Iodides (10)Ketones (156)Nitriles (29)Spiroes (19)Sulfamides (8)Sulfonic Acids (4)Sulfonyl Chlorides (8)Trifluoromethyls (19)Ureas (6)Aminobicyclo (24)Aminocyclobutanol (5)Aminocyclobutyl (5)Aminocyclohexane (54)Aminocyclohexanol (21)Aminocyclopentanol (17)Aminocyclopentyl (6)Aminocyclopropyl (4)Azabicyclo (289)Azatricyclo (5)Azetidine (177)Benzylazetidin (9)Bicyclo (59)Bicyclohexyl (6)Bromobicyclo (9)Butylcyclohexyl (9)Butylsulfonyl (6)Chlorocyclopropyl (2)Cyanoazetidine (5)Cyanocyclopropyl (4)Cyclobutanecarbonitrile (2)Cyclobutylacetic (4)Cyclobutylmethyl (4)Cyclohexa (163)Cyclohexane (119)Cyclohexanecarboxylic (19)Cyclohexanediamine (8)Cyclohexanone (92)Cyclohexylacetic (2)Cyclohexylamino (9)Cyclohexylbutanoic (4)Cyclohexylcarbamoyl (5)Cyclohexylethanamine (11)Cyclohexylmethoxy (4)Cyclohexylmethyl (7)Cyclohexyloxy (10)Cyclohexylpropan (75)Cyclohexylpropanoic (3)Cyclopentadienyl (2)Cyclopentane (165)Cyclopentanecarboxylic (7)Cyclopentyl (56)Cyclopentylacetic (3)Cyclopentylamino (1)Cyclopentylmethyl (4)Cyclopentyloxy (15)Cyclopropanamine (32)Cyclopropanecarbonitrile (14)Cyclopropanecarbonyl (6)Cyclopropanecarboxamide (14)Cyclopropanol (4)Cyclopropoxyphenyl (7)Cyclopropyl (356)Cyclopropylacetate (6)Cyclopropylacetic (3)Cyclopropylamino (24)Cyclopropylcarbamoyl (5)Cyclopropylethan (5)Cyclopropylethynyl (1)Cyclopropylmethoxy (32)Cyclopropylmethyl (20)Cyclopropylpropanoic (5)Cyclopropylsulfonyl (6)Diazabicyclo (77)Dicyclohexyl (6)Dicyclohexylphosphino (18)Difluorocyclobutyl (6)Difluorocyclohexyl (6)Dihydroinden (8)Dihydroindeno (5)Dihydropteridin (6)Dimethylbicyclo (5)Dimethylcyclohex (5)Dimethylcyclohexane (14)Dimethylcyclohexanone (7)Dioxathiolane (1)Dioxol (169)Dithiolan (1)Ethylcyclohexyl (4)Ethylsulfonyl (42)Fluoroazetidine (1)Fluorobicyclo (4)Hexahydrocyclohepta (6)Hexahydrocyclopenta (4)Hydroxycyclobutanecarboxylic (4)Hydroxycyclohexanecarboxylic (6)Methanesulfonyl (308)Methoxycyclohexanamine (6)Methylazetidine (30)Methylbicyclo (6)Methylcyclobutanamine (5)Methylcyclobutanecarboxylic (5)Methylcyclohexanamine (11)Methylcyclohexane (8)Methylcyclohexanecarboxylic (5)Methylcyclohexanecarboxylic Acid (4)Methylcyclohexanol (20)Methylcyclohexanone (4)Methylcyclohexyl (31)Methylcyclopentane (2)Methylcyclopropanamine (4)Methylcyclopropane (16)Methylsulfinyl (24)Methylsulfonimidoyl (6)Methylsulphonyl (10)Octahydrocyclopenta (14)Oxabicyclo (40)Oxazepane (13)Oxetanes (229)Oxoazetidine (8)Oxobicyclo (11)Oxocyclobutyl (2)Oxocyclohex (3)Oxocyclohexane (4)Oxocyclohexanecarboxylic (6)Oxocyclohexyl (3)Oxocyclopentane (2)Oxocyclopentyl (5)Pentamethylcyclopentadienyl (11)Pentylcyclohexyl (10)Phenylcyclopropanamine (8)Propylcyclohexyl (15)Tetraazacyclododecane (13)Tetraazacyclotetradecane (7)Tetramethylcyclohexane (4)Tetraoxatridecan (3)Thiazepine (2)Tricyclohexylphosphine (8)Trimethylbicyclo (19)Trimethylcyclohex (20)(1-Phenylcyclobutyl)Methanamine (9)(1-Phenylcyclopropyl)Methanamine (12)(1-Phenylcyclopropyl)Methanol (3)(3Ar,E)-4-((Z)-2-(2-Methylenecyclohexylidene)Ethylidene)Octahydro-1H-Indene (7)(4-Cyclohexylphenyl)Boronic Acid (7)(4-Pentylcyclohexyl)Benzene (5)(4-Propylcyclohexyl)Benzene (5)(9H-Fluoren-2-Yl)Boronic Acid (6)(9H-Fluoren-9-Yl)Methyl (4-Methoxybenzyl)Carbamate (7)(Cyclopropylmethoxy)Benzene (18)1,1-Difluorocyclobutane (14)1,1-Difluorocyclohexane (18)1,1-Difluorocyclopentane (5)1-Bromo-2-Cyclopropylbenzene (3)1-Bromo-3-Cyclopropylbenzene (6)1-Chloro-2-Cyclopropylbenzene (7)1-Cyclohexyl-2-Fluorobenzene (4)1-Cyclopropyl-3-Methylbenzene (3)1-Methylcyclohex-1-Ene (24)1-Phenylcyclobutan-1-Amine (5)1-Phenylcyclobutane-1-Carbonitrile (7)1-Phenylcyclobutane-1-Carboxylic Acid (16)1-Phenylcyclohexane-1-Carboxylic Acid (6)1-Phenylcyclopropan-1-Amine (26)1-Phenylcyclopropane-1-Carbonitrile (19)1-Phenylcyclopropane-1-Carboxylic Acid (23)2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-2-Phenylacetic Acid (5)2-Bromo-9,9-Diphenyl-9H-Fluorene (5)2-Bromo-9H-Fluorene (15)2-Cyclohexylacetic Acid (13)2-Cyclopropyl-4-Phenylquinoline (12)2-Cyclopropylpyridine (20)2-Cyclopropylpyrimidine (10)2-Iodo-9H-Fluorene (8)2-Methylcyclohexan-1-One (3)2-Phenylcyclopropan-1-Amine (20)3,3-Dimethylcyclohexan-1-One (4)3-Cyclopropylpyridine (28)3-Methylcyclohexan-1-One (9)4-Cyclohexylbenzoic Acid (6)4-Cyclohexylbenzonitrile (10)4-Cyclohexylphenol (7)5-Azaspiro[2.4]Heptane (13)6-Azaspiro[2.5]Octane (10)9,9-Dimethyl-9H-Fluorene (16)Bicyclo[1.1.1]Pentan-1-Ylmethanol (3)Bicyclo[1.1.1]Pentane-1-Carboxylic Acid (6)Bicyclo[2.2.1]Hept-2-Ene (18)Bicyclo[2.2.1]Heptane (14)Bromocyclohexane (7)Cyclobutanamine (90)Cyclobutanecarboxylic Acid (23)Cyclobutanol (46)Cyclobutylmethanol (15)Cycloheptane (12)Cyclohex-3-Ene-1-Carboxylic Acid (7)Cyclohexanamine (59)Cyclohexanecarboxylic Acid (83)Cyclohexanol (70)Cyclohexylmethanol (31)Cyclopentanamine (5)Cyclopentanecarboxylic Acid (26)Cyclopentanol (51)Cyclopropoxybenzene (13)Ethyl 1-Phenylcyclopropane-1-Carboxylate (4)Ethyl 2-Phenylcyclopropane-1-Carboxylate (5)Ethyl Cyclohexanecarboxylate (33)Isopropylcyclohexane (19)Methoxycyclohexane (7)Methyl 1-Phenylcyclopropane-1-Carboxylate (10)Methyl 4-Oxocyclohexane-1-Carboxylate (5)Methyl Bicyclo[1.1.1]Pentane-1-Carboxylate (10)Methyl Cyclobutanecarboxylate (24)Methyl Cyclohexanecarboxylate (45)Methyl Cyclopentanecarboxylate (18)N-Methylcyclohexanamine (7)Naphthalene-1,4-Dione (22)Spiro[3.3]Heptane (11)Tert-Butyl (1-Phenylcyclopropyl)Carbamate (6)Tert-Butyl (2-Phenylcyclopropyl)Carbamate (4)Tert-Butyl Bicyclo[1.1.1]Pentan-1-Ylcarbamate (5)Tert-Butyl Cyclobutylcarbamate (17)Tert-Butyl Cyclohexylcarbamate (9)Tert-Butyl Cyclopentylcarbamate (28)
Alkenyls (16040)
Acyl Chlorides (7)Alcohols (101)Aldehydes (29)Aliphatic Chain Hydrocarbons (380)Aliphatic Cyclic Hydrocarbons (57)Amides (96)Amines (112)Anhydrides (4)Aryls (277)Benzyl Chlorides (1)Bromides (45)Carboxylic Acid Salts (9)Carboxylic Acids (126)Chlorides (55)Esters (243)Ethers (79)Fluorinated Building Blocks (42)Furans (9)Imidazoles (7)Indoles (4)Indolines (3)Iodides (6)Ketones (84)Nitriles (62)Nitroes (21)Oxetanes (4)Phenols (13)Piperazines (8)Piperidines (18)Pyridines (36)Pyrimidines (10)Pyrrolidines (14)Quinolines (10)Quinuclidines (6)Spiroes (4)Sulfamides (12)Sulfones (12)Tetrahydropyrans (7)Thiophenes (15)Trifluoromethyls (5)Other Aliphatic Heterocycles (19)Other Aromatic Heterocycles (5)Acrylaldehyde (11)Acryloyl (8)Annulene (2)Cyclohexene (86)Cyclooctene (7)Cyclopentene (3)Diacrylamide (6)Diallyl (4)Diazene (21)Divinyl (1)Enamide (6)Enecarbaldehyde (2)Enoyl (7)Methacrylamide (3)Methoxycinnamaldehyde (3)Nitroethylene (37)Tetrahydrocyclopenta (19)(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (7)(1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (6)(2,2-Dibromovinyl)Benzene (6)(2-(4-Bromophenyl)Ethene-1,1,2-Triyl)Tribenzene (11)(2-Nitrovinyl)Benzene (28)(Allyloxy)Benzene (17)(E)-5-Benzylidenethiazolidine-2,4-Dione (6)(E)-[3,3'-Biindolinylidene]-2,2'-Dione (5)(E)-N-(3-Oxo-1-Phenyl-3-(Piperidin-1-Yl)Prop-1-En-2-Yl)Benzamide (6)(Z)-3-(Phenyl(Phenylamino)Methylene)Indolin-2-One (5)(Z)-3-Benzylideneindolin-2-One (7)1,2-Diphenylethene (5)1,3,3-Trimethylcyclohex-1-Ene (12)1-Bromo-4-Styrylbenzene (5)1-Methylcyclohex-1-Ene (24)2-Benzalacetophenone (36)2-Methoxycyclohexa-2,5-Diene-1,4-Dione (7)2-Methylcyclohexa-2,5-Diene-1,4-Dione (5)3-(2-Fluorophenyl)Acrylic Acid (17)3-(3-Chlorophenyl)Acrylic Acid (10)3-Methylene-2,3-Dihydro-1H-Inden-1-One (3)3-Methyleneazetidine (8)3-Phenylacrylaldehyde (29)3-Styrylphenol (10)4-(1,2,2-Triphenylvinyl)Benzaldehyde (5)4-(Prop-1-En-2-Yl)Cyclohex-1-Ene (3)5H-Dibenzo[B,F]Azepine (5)Allyl Benzoate (5)Cyclohex-1-En-1-Yl Trifluoromethanesulfonate (3)Cyclohex-1-En-1-Ylboronic Acid (4)Cyclohex-1-Ene-1-Carboxylic Acid (4)Cyclohexa-1,3-Diene (4)Cyclopent-2-En-1-Amine (4)Ethyl Cyclohex-1-Ene-1-Carboxylate (5)Methyl Cinnamate (37)Methyl Cyclohex-3-Ene-1-Carboxylate (3)Methylenecyclobutane (8)Methylenecyclohexane (8)N-Phenylacrylamide (7)Styrene (78)Tert-Butyl-Cyclopent-2-En-1-Ylcarbamate (6)Vinylcyclopropane (8)
Alkyls (192)
Isopropyl-Phenyl-Boronic Acid/Ester (26)Methylpentan (3)
Alkynyls (2683)
Alcohols (34)Aldehydes (6)Aliphatic Chain Hydrocarbons (23)Amides (30)Amines (19)Aryls (116)Bromides (11)Carboxylic Acids (13)Chlorides (18)Esters (19)Ethers (29)Fluorinated Building Blocks (6)Ketones (8)Pyrazines (6)Pyridines (17)Pyrimidines (7)Pyrrolidines (8)(Bromoethynyl)Benzene (5)(Prop-2-Yn-1-Yloxy)Benzene (12)1,3,5-Tris(Phenylethynyl)Benzene (6)1,4-Bis(Phenylethynyl)Benzene (7)1,4-Diphenylbuta-1,3-Diyne (9)1-Ethynyl-2-Fluorobenzene (10)1-Methyl-4-(Phenylethynyl)Benzene (7)2-(Phenylethynyl)Benzaldehyde (9)2-Ethynylpyridine (31)2-Ethynylthiophene (8)3-Ethynylpyridine (22)4-(Phenylethynyl)-1,1'-Biphenyl (5)4-(Phenylethynyl)Phenol (7)4-Ethynylpyridine (10)9,10-Bis(Phenylethynyl)Anthracene (5)Ethynylbenzene (145)Trimethyl(Phenylethynyl)Silane (23)
Amides (88466)
Acyl Chlorides (13)Alcohols (364)Aldehydes (56)Aliphatic Chain Hydrocarbons (455)Aliphatic Cyclic Hydrocarbons (132)Alkenyls (96)Alkynyls (30)Amidines (8)Amines (607)Anhydrides (33)Aryls (1172)Azetidines (102)Benzimidazoles (26)Benzisoxazoles (4)Benzofurans (7)Benzothiazoles (23)Benzoxazoles (33)Benzyl Bromides (6)Benzyl Chlorides (8)Bromides (309)Carboxylic Acid Salts (4)Carboxylic Acids (224)Chlorides (371)Epoxides (10)Esters (300)Ethers (251)Fluorinated Building Blocks (235)Furans (30)Guanidines (12)Hydrazides (168)Hydrazines (175)Hydrazones (9)Hydroxylamines (12)Imidazoles (26)Imidazolidines (18)Imidazolines (16)Indazoles (6)Indoles (41)Indolines (73)Iodides (36)Isoquinolines (10)Isoxazoles (16)Ketones (185)Morpholines (95)Nitriles (92)Oxadiazoles (10)Oxazoles (10)Oxazolidines (49)Oxazolines (4)Oxetanes (14)Phenols (41)Phthalazines (6)Piperazines (259)Piperidines (433)Purines (7)Pyrazines (17)Pyrazoles (46)Pyridazines (20)Pyridines (267)Pyrimidines (119)Pyrroles (15)Pyrrolidines (307)Pyrrolines (24)Quinazolines (42)Quinolines (33)Quinoxalines (15)Spiroes (190)Sulfamides (43)Sulfides (40)Sulfonates (15)Sulfones (13)Tetrahydrofurans (19)Tetrahydroisoquinolines (7)Tetrahydropyrans (15)Tetrahydroquinolines (14)Thiadiazoles (11)Thiazoles (40)Thiazolidines (16)Thioesters (25)Thiols (4)Thiophenes (44)Thiophenols (6)Thioureas (61)Triazines (11)Triazoles (8)Trifluoromethyls (74)Ureas (80)Other Aliphatic Heterocycles (102)Other Aromatic Heterocycles (176)Acetamide (639)Acetamido (145)Carboxamide (893)Diacetamide (3)Dicarboxamide (19)Diethylacetamide (4)Dimethylacetamide (9)Dimethylnicotinamide (7)Formamidophenylboronic Acid/Ester (11)Isobutyramide (7)Oxobutanamide (10)Pentanamide (15)Propanamido (5)(3-(Phenylcarbamoyl)Phenyl)Boronic Acid (3)(4-(Phenylcarbamoyl)Phenyl)Boronic Acid (11)(9H-Fluoren-9-Yl)Methyl (3-Phenylpropyl)Carbamate (24)(S)-N-Phenethyl-3-(Pyrrolidin-2-Yl)Propanamide (5)(S)-N-Phenylpiperidine-2-Carboxamide (1)1-(Pyridin-2-Yl-L2-Azaneyl)Ethan-1-One (12)1-Methylindoline-2,3-Dione (8)1-Phenylurea (11)1H-Pyrazole-5-Carboxamide (3)2,2-Dimethyl-1-(Pyridin-2-Yl-L2-Azaneyl)Propan-1-One (7)2-((Tert-Butoxycarbonyl)Amino)Benzoic Acid (11)2-(Trifluoromethyl)Benzamide (6)2-Amino-N-Phenylbenzamide (21)2-Aminobenzamide (30)2-Bromo-N-Phenylacetamide (5)2-Chloro-N-Phenylacetamide (26)2-Chloro-N-Phenylbenzamide (4)2-Chlorobenzamide (16)2-Fluoro-N-Methylbenzamide (12)2-Fluorobenzamide (32)2-Hydroxy-N-Phenylbenzamide (3)2-Hydroxybenzamide (14)2-Iodobenzamide (4)2-Methoxybenzamide (9)3-Benzamidopropanoic Acid (3)3-Bromo-4-Fluorobenzamide (3)3-Fluorobenzamide (26)3-Nitrobenzamide (17)3-Oxo-N-Phenylbutanamide (10)4-Amino-N-Phenylbenzamide (7)4-Benzamidobenzoic Acid (3)4-Fluorobenzamide (19)4-Oxo-4-(Phenylamino)Butanoic Acid (7)Benzoylglycine (15)Benzyl Benzylcarbamate (14)Benzyl Cyclohexylcarbamate (9)Benzyl Phenylcarbamate (15)Ethyl 2-Oxo-2-(Phenylamino)Acetate (8)Isonicotinamide (12)N,N-Diethylbenzamide (17)N,N-Dimethylbenzamide (34)N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-3-Phenylisoxazole-4-Carboxamide (1)N-((6R,7R)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-7-Yl)-2-Phenylacetamide (5)N-(2-(1H-Indol-3-Yl)Ethyl)Acetamide (5)N-(2-Benzoylphenyl)-2-Bromoacetamide (3)N-(2-Chlorophenyl)Acetamide (16)N-(2-Iodophenyl)Acetamide (8)N-(2-Nitrophenyl)Acetamide (11)N-(3-Fluorophenyl)Acetamide (14)N-(4-Aminophenyl)Benzamide (2)N-(4-Chlorophenyl)Acetamide (9)N-(4-Chlorophenyl)Benzamide (6)N-(4-Fluorophenyl)Benzamide (3)N-(4-Phenoxyphenyl)Acetamide (4)N-(O-Tolyl)Benzamide (9)N-(P-Tolyl)Benzamide (6)N-(Thiazol-2-Yl)Acetamide (9)N-Isopropylbenzamide (16)N-Methoxy-N-Methylbenzamide (24)N-Methylbenzamide (58)N-Methylpicolinamide (10)N-Phenylacrylamide (7)N-Phenylpivalamide (11)Nicotinamide (61)Phenyl Dimethylcarbamate (5)Phenyl Ethyl(Methyl)Carbamate (5)Picolinamide (26)Piperidine-3-Carboxamide (5)Pyrazine-2-Carboxamide (10)Pyrrolidine-2-Carboxamide (12)Tert-Butyl (1-Phenylethyl)Carbamate (19)Tert-Butyl (4-Fluorophenyl)Carbamate (9)Tert-Butyl Benzylcarbamate (52)Tert-Butyl Methyl(Phenyl)Carbamate (9)Tert-Butyl O-Tolylcarbamate (11)Tert-Butyl Phenethylcarbamate (1)Tert-Butyl-Cyclopent-2-En-1-Ylcarbamate (6)Thiophene-3-Carboxamide (5)
Amidines (1559)
Aliphatic Chain Hydrocarbons (21)Amides (8)Amines (6)Aryls (20)Chlorides (9)Ethers (4)Fluorinated Building Blocks (7)Hydrazines (2)Oximes (24)Pyridines (13)Pyrimidines (4)Trifluoromethyls (3)Carbamimidoyl (16)Benzimidamide (48)N'-Hydroxybenzimidamide (13)Picolinimidamide (11)
Amines (137938)
Alcohols (287)Aldehydes (29)Aliphatic Chain Hydrocarbons (304)Aliphatic Cyclic Hydrocarbons (135)Alkenyls (112)Alkynyls (19)Amides (607)Amidines (6)Aryls (1256)Azetidines (17)Benzimidazoles (19)Benzisoxazoles (4)Benzodioxans (5)Benzofurans (13)Benzothiazoles (30)Benzothiophenes (6)Benzoxazoles (7)Bromides (216)Carboxylic Acid Salts (4)Carboxylic Acids (178)Chlorides (308)Difluoromethyls (19)Dioxolanes (4)Esters (299)Ethers (400)Fluorinated Building Blocks (282)Furans (22)Hydrazides (8)Hydrazines (26)Hydroxylamines (14)Imidazoles (38)Imidazolines (4)Indazoles (18)Indoles (29)Indolines (9)Iodides (36)Isoquinolines (12)Isoxazoles (25)Ketones (87)Morpholines (54)Nitriles (142)Nitroes (112)Oxadiazoles (16)Oxazoles (16)Oxazolidines (4)Oxetanes (28)Oximes (5)Phenols (26)Piperazines (26)Piperidines (176)Purines (12)Pyrazines (19)Pyrazoles (159)Pyridazines (10)Pyridines (393)Pyrimidines (191)Pyrroles (10)Pyrrolidines (81)Quinazolines (9)Quinolines (79)Quinoxalines (7)Quinuclidines (5)Spiroes (13)Sulfamides (50)Sulfides (41)Sulfonates (6)Sulfones (20)Sulfonic Acids (11)Tetrahydrofurans (7)Tetrahydroisoquinolines (3)Tetrahydropyrans (3)Tetrahydroquinolines (5)Thiadiazoles (24)Thiazoles (102)Thioesters (5)Thiophenes (54)Thiophenols (5)Triazines (13)Triazoles (21)Trifluoromethyls (95)Ureas (6)Other Aliphatic Heterocycles (17)Other Aromatic Heterocycles (129)Amino-Propanol (6)Aminoacetamido (4)Aminoacetyl (2)Aminoadamantan (5)Aminoazepane (10)Aminobutane (23)Aminobutyl (15)Aminoethoxy (18)Aminoethyl (151)Aminohexan (6)Aminohexyl (3)Aminoisonicotinic Acid (12)Aminomethyl (398)Aminooxy (6)Aminopentyl (10)Aminopropanamido (1)Aminopropane (20)Aminopropoxy (2)Aminopyridine (74)Aminotetrahydro (12)Benzylazetidine (4)Bromobenzylamine (6)Bromobenzylcarbamate (28)Butoxycarbonylamino (7)Butylcarbamoyl (5)Carbamothioyl (2)Carbamoyl (112)Chlorobenzylamine (4)Diamino (85)Diaminopteridin (3)Dibutylamino (6)Dichlorobenzylamine (5)Diethylamino (89)Diisopropylamino (1)Dimethylamino (475)Dimethylcarbamoyl (14)Dimethylmethanamine (16)Dipropylamino (1)Ethylamino (37)Fluindamine (32)Hydroxyamino (2)Methoxyimino (2)Methylamino (234)Methylcarbamoyl (18)Propanediamine (6)Propylamino (5)Pyrrolopyridine-Methylamine (6)Silanamine (3)Triamine (25)(1-Phenylcyclobutyl)Methanamine (9)(1-Phenylcyclopropyl)Methanamine (12)(1H-Benzo[D]Imidazol-2-Yl)Methanamine (7)(2,3-Dihydrobenzo[B][1,4]Dioxin-2-Yl)Methanamine (3)(2-Aminophenyl)(Phenyl)Methanone (30)(2-Bromophenyl)Methanamine (12)(2-Chlorophenyl)Methanamine (28)(2-Fluorophenyl)Methanamine (49)(3-Chlorophenyl)Methanamine (19)(3-Fluoropyridin-2-Yl)Methanamine (5)(3-Methylpyridin-2-Yl)Methanamine (5)(4-Aminophenyl)(Phenyl)Methanone (4)(4-Fluorophenyl)Methanamine (27)(6-Methylpyridin-2-Yl)Methanamine (6)(Tetrahydrofuran-2-Yl)Methanamine (2)(Tetrahydrofuran-3-Yl)Methanamine (3)1,2,3,4-Tetrahydroisoquinolin-5-Amine (4)1,2,3,4-Tetrahydroisoquinolin-6-Amine (3)1,2,3,4-Tetrahydroisoquinolin-7-Amine (3)1,3,4-Thiadiazol-2-Amine (9)1,3,5-Triazin-2-Amine (3)1-(2,3-Dihydro-1H-Inden-5-Yl)Ethan-1-Amine (3)1-(2-Aminophenyl)Ethan-1-One (29)1-(2-Bromophenyl)Ethan-1-Amine (10)1-(2-Chlorophenyl)-1H-Pyrazole (3)1-(2-Fluorophenyl)Ethan-1-Amine (80)1-(2-Fluorophenyl)Propan-1-Amine (8)1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine (25)1-(3-Aminophenyl)Ethan-1-One (18)1-(3-Chlorophenyl)-N-Methylmethanamine (8)1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(Anthracen-9-Yl)Ethan-1-Amine (3)1-(Pyridin-2-Yl)Ethan-1-Amine (15)1-(Pyridin-3-Yl)Ethan-1-Amine (17)1-(Pyridin-4-Yl)Ethan-1-Amine (23)1-Aminoanthracene-9,10-Dione (8)1-Benzyl-N-Methylpiperidin-3-Amine (6)1-Benzylpiperidin-4-Amine (8)1-Methyl-1H-Pyrazol-3-Amine (14)1-Phenyl-1H-Pyrazol-3-Amine (3)1-Phenyl-1H-Pyrazol-5-Amine (4)1-Phenylcyclobutan-1-Amine (5)1-Phenylcyclopropan-1-Amine (26)1-Phenylethan-1-Amine (436)1H-1,2,4-Triazol-3-Amine (6)1H-1,2,4-Triazol-5-Amine (5)1H-Benzo[D]Imidazol-2-Amine (7)1H-Benzo[D]Imidazol-5-Amine (4)1H-Benzo[D]Imidazol-6-Amine (6)1H-Imidazol-2-Amine (6)1H-Indazol-3-Amine (23)1H-Indazol-4-Amine (12)1H-Indazol-5-Amine (3)1H-Indazol-6-Amine (5)1H-Indazol-7-Amine (6)1H-Indol-4-Amine (10)1H-Indol-6-Amine (21)1H-Indol-7-Amine (10)1H-Pyrazol-4-Amine (6)1H-Pyrazol-5-Amine (19)1H-Pyrrol-1-Amine (7)1H-Pyrrolo[2,3-B]Pyridin-6-Amine (4)2,2,2-Trifluoro-1-Phenylethan-1-Amine (48)2,3-Dichloroaniline (18)2,3-Difluoroaniline (34)2,3-Dihydrobenzofuran-3-Amine (11)2,3-Dihydrobenzofuran-5-Amine (3)2,4-Dibromoaniline (18)2,4-Dichloropyrimidin-5-Amine (6)2,4-Difluoroaniline (44)2,5-Difluoroaniline (34)2,6-Dibromoaniline (17)2,6-Dichloroaniline (26)2,6-Difluoroaniline (23)2,6-Diiodoaniline (8)2-((2-Nitrophenyl)Amino)Ethan-1-Ol (5)2-(1H-Benzo[D]Imidazol-2-Yl)Ethan-1-Amine (6)2-(1H-Indol-3-Yl)Ethan-1-Amine (4)2-(Diethylamino)Ethyl Benzoate (3)2-(Methylsulfonyl)Aniline (3)2-(Phenylamino)Benzoic Acid (11)2-(Piperazin-1-Yl)Ethan-1-Amine (8)2-(Piperidin-1-Yl)Ethan-1-Amine (8)2-(Trifluoromethoxy)Aniline (18)2-(Trifluoromethyl)Aniline (58)2-Amino-2-(2-Fluorophenyl)Ethan-1-Ol (7)2-Amino-2-Phenylethan-1-Ol (196)2-Amino-3-Chlorophenol (4)2-Amino-3-Fluorobenzoic Acid (11)2-Amino-6-Bromophenol (3)2-Amino-6-Chlorobenzoic Acid (5)2-Amino-6-Chlorobenzonitrile (3)2-Amino-6-Chlorophenol (5)2-Aminobenzamide (30)2-Aminobenzenesulfonic Acid (9)2-Aminophenol (106)2-Aminopyrimidin-4(3H)-One (11)2-Bromo-3-Chloroaniline (4)2-Bromo-3-Fluoroaniline (13)2-Bromo-3-Methylaniline (6)2-Bromo-4-Methylaniline (14)2-Bromo-6-Methylaniline (11)2-Bromo-N,N-Dimethylaniline (5)2-Bromo-N-Methylaniline (8)2-Chloro-3-Methylaniline (4)2-Chloro-4-Methylaniline (7)2-Chloro-6-Methylaniline (11)2-Chloro-N-Methylaniline (4)2-Chloro-N-Phenylaniline (8)2-Chloroaniline (213)2-Chlorobenzene-1,3-Diamine (3)2-Chlorobenzene-1,4-Diamine (6)2-Chloropyrimidin-4-Amine (22)2-Fluoro-6-Iodoaniline (7)2-Fluoro-N-Phenylaniline (4)2-Fluoroaniline (262)2-Iodo-4-Methylaniline (5)2-Iodo-N,N-Dimethylaniline (3)2-Iodoaniline (87)2-Methoxypyridin-3-Amine (6)2-Methyl-6-Nitroaniline (10)2-Methyl-N-Phenylaniline (7)2-Methylpyridin-4-Amine (7)2-Methylpyrimidin-4-Amine (22)2-Nitro-N-Phenylaniline (3)2-Phenoxyaniline (4)2-Phenylcyclopropan-1-Amine (20)2-Phenylpyrimidin-5-Amine (5)3,4-Dibromoaniline (4)3,4-Dichloroaniline (21)3,4-Difluoroaniline (44)3-(1,3,2-Dioxaborinan-2-Yl)Aniline (3)3-(Benzyloxy)Aniline (12)3-(Methylsulfonyl)Aniline (7)3-(Trifluoromethoxy)Aniline (22)3-(Trifluoromethyl)Aniline (102)3-Aminobenzenesulfonic Acid (6)3-Aminodihydrofuran-2(3H)-One (4)3-Bromo-2-Fluoroaniline (15)3-Bromo-4-Chloroaniline (13)3-Bromo-4-Fluoroaniline (22)3-Bromo-4-Methoxyaniline (7)3-Bromo-4-Methylaniline (14)3-Bromoaniline (187)3-Bromobenzene-1,2-Diamine (11)3-Chloro-2-Iodoaniline (3)3-Chloro-2-Methylaniline (11)3-Chloro-4-Fluoroaniline (18)3-Chloro-4-Iodoaniline (3)3-Chloro-4-Methoxyaniline (6)3-Chloro-4-Methylaniline (12)3-Chlorobenzene-1,2-Diamine (6)3-Chloropyrazin-2-Amine (6)3-Fluoro-2-Methylaniline (9)3-Fluoroaniline (288)3-Iodo-2-Methylaniline (4)3-Iodoaniline (32)3-Methoxypyridin-2-Amine (5)3-Methyl-N-Phenylaniline (4)3-Methylpyridin-2-Amine (7)3-Nitroaniline (98)3-Phenoxyaniline (2)3-Phenyl-1H-Pyrazol-5-Amine (11)3-Phenylisoxazol-5-Amine (8)4,6-Dichloropyrimidin-2-Amine (9)4-(Benzyloxy)Aniline (8)4-(Oxazol-5-Yl)Aniline (3)4-(Pyrrolidin-1-Yl)Aniline (3)4-(Trifluoromethoxy)Aniline (26)4-Amino-2-Chlorobenzonitrile (8)4-Amino-2-Fluorophenol (9)4-Amino-3-Chlorobenzoic Acid (6)4-Amino-3-Chlorophenol (5)4-Amino-N-Phenylbenzenesulfonamide (3)4-Aminopyridazin-3(2H)-One (4)4-Benzylaniline (7)4-Bromo-3-Chloroaniline (21)4-Bromo-3-Fluoroaniline (29)4-Bromo-3-Methylaniline (19)4-Bromo-3-Nitroaniline (8)4-Bromo-N,N-Diphenylaniline (10)4-Bromo-N-Phenylaniline (6)4-Chloro-2-Iodoaniline (9)4-Chloro-3-Fluoroaniline (17)4-Chloro-3-Iodoaniline (3)4-Chloro-3-Methylaniline (11)4-Chloro-N-Phenylaniline (6)4-Chloropyrimidin-2-Amine (23)4-Chloropyrimidin-5-Amine (7)4-Fluoro-N-Phenylaniline (4)4-Fluoroaniline (226)4-Iodo-N,N-Diphenylaniline (3)4-Methoxy-N-Phenylaniline (5)4-Methyl-3-Nitroaniline (8)4-Methylpyrimidin-2-Amine (9)4-Methylthiazol-2-Amine (7)4-Morpholinoaniline (4)4-Nitroaniline (64)4-Phenoxyaniline (6)4-Phenylpyrimidin-2-Amine (15)4-Phenylthiazol-2-Amine (37)5-Bromopyrazin-2-Amine (13)5-Bromothiazol-2-Amine (6)5-Chloropyrazin-2-Amine (9)5-Methoxypyridin-3-Amine (4)5-Methyl-2-Nitroaniline (6)5-Methylpyridin-2-Amine (7)5-Methylpyridin-3-Amine (4)5-Methylthiazol-2-Amine (6)5-Phenylthiophen-2-Amine (5)5H-Dibenzo[B,F]Azepine (5)6-Amino-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)6-Bromopyrazin-2-Amine (5)6-Chloropyrazin-2-Amine (11)6-Chloropyridazin-3-Amine (5)6-Chloropyrimidin-4-Amine (8)6-Methoxypyridin-2-Amine (14)6-Methoxypyridin-3-Amine (8)6-Methylpyridin-2-Amine (46)6-Methylpyridin-3-Amine (5)6-Phenoxypyridin-3-Amine (5)7-Methoxy-N-Phenylquinazolin-4-Amine (12)7H-Purin-2-Amine (6)7H-Purin-6-Amine (9)7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine (5)7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine (3)9H-Purin-6-Amine (3)[1,1'-Biphenyl]-2-Amine (8)[1,1'-Biphenyl]-3-Amine (11)[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine (17)[1,2,4]Triazolo[4,3-A]Pyridin-3-Ylmethanamine (5)Azetidin-3-Amine (4)Azetidin-3-Ylmethanamine (3)Aziridine (9)Benzo[B]Thiophen-2-Amine (5)Benzo[D]Oxazol-2-Amine (16)Benzo[D]Thiazol-2-Amine (30)Benzo[D]Thiazol-5-Amine (3)Benzo[D]Thiazol-6-Amine (3)Benzyl-3-Aminopiperidine-1-Carboxylate (6)Benzyl-3-Aminopyrrolidine-1-Carboxylate (7)Bis(Pyridin-2-Ylmethyl)Amine (6)Chroman-2-Ylmethanamine (3)Chroman-4-Amine (20)Cyclobutanamine (90)Cyclohexanamine (59)Cyclopent-2-En-1-Amine (4)Cyclopentanamine (5)Cyclopropyl(Phenyl)Methanamine (22)Diphenylmethanamine (26)Ethyl 2-Aminobenzoate (23)Ethyl 3-Aminobenzoate (19)Ethyl 4-Aminobenzoate (22)Imidazo[1,2-A]Pyridin-3-Amine (7)Imidazo[1,2-A]Pyridin-8-Amine (7)Isoquinolin-1-Amine (18)Isoquinolin-3-Amine (13)Isoquinolin-4-Amine (16)Isoquinolin-5-Amine (9)Isoquinolin-8-Amine (6)Isoxazol-5-Amine (15)Methyl 2-Amino-2-Phenylacetate (38)Methyl 2-Aminobenzoate (95)Methyl 3-Amino-3-Phenylpropanoate (27)Methyl 3-Aminobenzoate (88)Methyl 4-Aminobenzoate (71)Morpholin-2-Ylmethanamine (8)N,N-Diethylaniline (18)N,N-Dimethyl-2-Phenoxyethan-1-Amine (16)N,N-Dimethylaniline (117)N,N-Dimethylnaphthalen-1-Amine (3)N,N-Dimethylpyridin-2-Amine (10)N,N-Dimethylpyridin-4-Amine (6)N,N-Dimethylpyrimidin-2-Amine (10)N,N-Dimethylpyrrolidin-3-Amine (7)N,N-Diphenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (6)N,N-Diphenyl-[1,1'-Biphenyl]-4-Amine (8)N-(4-Aminophenyl)Benzamide (2)N-(Furan-2-Ylmethyl)Aniline (5)N-(Prop-2-Yn-1-Yl)-2,3-Dihydro-1H-Inden-1-Amine (3)N-Benzyl-1-Phenylethan-1-Amine (7)N-Benzyl-2-Phenylethan-1-Amine (1)N-Benzylpiperidin-4-Amine (3)N-Cyclopropylpyrimidin-2-Amine (5)N-Methyl-1-Phenylmethanamine (65)N-Methyl-2-Nitroaniline (20)N-Methyl-4-Nitroaniline (5)N-Methylaniline (139)N-Methylcyclohexanamine (7)N-Methylpiperidin-3-Amine (5)N-Methylpyridin-2-Amine (47)N-Methylpyridin-3-Amine (15)N-Methylpyrimidin-2-Amine (10)N-Methylpyrimidin-4-Amine (10)N-Methylpyrrolidin-3-Amine (6)N-Phenyl-3-(Trifluoromethyl)Aniline (3)N-Phenyl-4-(Trifluoromethyl)Aniline (3)N-Phenylnaphthalen-1-Amine (5)N-Phenylpyridin-2-Amine (9)N-Phenylpyrimidin-2-Amine (5)N-Phenylpyrimidin-4-Amine (7)N1,N1-Diphenylbenzene-1,4-Diamine (2)N1-Phenylbenzene-1,4-Diamine (3)N2,N4,N6-Triphenyl-1,3,5-Triazine-2,4,6-Triamine (4)N2,N4-Diphenylpyrimidine-2,4-Diamine (5)Naphthalen-2-Amine (12)O-Benzylhydroxylamine (16)Oxazol-2-Amine (8)Phenylmethanamine (315)Piperidin-2-Ylmethanamine (6)Piperidin-3-Amine (17)Piperidin-3-Ylmethanamine (5)Piperidin-4-Amine (14)Piperidin-4-Ylmethanamine (7)Pyrazin-2-Amine (22)Pyrazin-2-Ylmethanamine (12)Pyridazin-3-Amine (18)Pyridazin-4-Amine (10)Pyridin-2-Amine (29)Pyridin-2-Ylmethanamine (38)Pyridin-3-Amine (21)Pyridin-3-Ylmethanamine (29)Pyridin-4-Amine (22)Pyridin-4-Ylmethanamine (12)Pyridine-2,3-Diamine (5)Pyridine-2,6-Diamine (12)Pyrimidin-2-Ylmethanamine (7)Pyrimidin-4-Amine (29)Pyrimidin-5-Amine (6)Pyrimidine-2,4-Diamine (14)Pyrrolidin-2-Ylmethanamine (12)Pyrrolidin-3-Ylmethanamine (6)Quinazolin-2-Amine (13)Quinazolin-4-Amine (8)Quinoxalin-2-Amine (3)Tetrahydrofuran-3-Amine (6)Thiazol-2-Ylmethanamine (5)Thiazol-5-Amine (6)Thiophen-3-Amine (18)Tri([1,1'-Biphenyl]-4-Yl)Amine (8)
Anhydrides (660)
Aliphatic Chain Hydrocarbons (11)Alkenyls (4)Amides (33)Aryls (14)Benzofurans (13)Bromides (5)Chlorides (8)Esters (81)Ethers (8)Fluorinated Building Blocks (8)Nitroes (5)Oxazolidines (5)Tetrahydrofurans (3)Other Aliphatic Heterocycles (10)Other Aromatic Heterocycles (33)Dianhydride (2)1H,3H-Benzo[De]Isochromene-1,3-Dione (8)Furan-2,5-Dione (8)
Aryls (184478)
Acyl Chlorides (28)Alcohols (626)Aldehydes (346)Aliphatic Cyclic Hydrocarbons (10)Alkenyls (277)Alkynyls (116)Amides (1172)Amidines (20)Amines (1256)Anhydrides (14)Azetidines (44)Azoes (12)Benzimidazoles (40)Benzofurans (12)Benzothiazoles (10)Benzothiophenes (4)Benzyl Bromides (82)Benzyl Chlorides (53)Bromides (934)Carboxylic Acid Salts (13)Carboxylic Acids (839)Chlorides (1041)Difluoromethyls (43)Dioxolanes (16)Epoxides (25)Esters (876)Ethers (1450)Fluorinated Building Blocks (858)Furans (39)Guanidines (13)Hydrazides (84)Hydrazines (121)Hydrazones (10)Hydroxylamines (8)Imidazoles (50)Imidazolidines (9)Imidazolines (14)Indazoles (7)Indoles (50)Indolines (20)Iodides (86)Isocyanates and Isothiocyanates (8)Isocyanides (2)Isoxazoles (54)Ketones (575)Morpholines (137)Nitriles (348)Nitroes (348)Oxadiazoles (12)Oxazoles (48)Oxazolidines (24)Oxazolines (8)Oxetanes (20)Oximes (24)Phenols (278)Phosphoruses (9)Piperazines (85)Piperidines (304)Purines (4)Pyrans (3)Pyrazines (13)Pyrazoles (121)Pyridazines (15)Pyridines (178)Pyrimidines (77)Pyrroles (30)Pyrrolidines (141)Pyrrolines (14)Quinazolines (7)Quinolines (24)Quinuclidines (2)Spiroes (36)Sulfamides (216)Sulfides (143)Sulfonates (83)Sulfones (118)Sulfonic Acids (22)Sulfonyl Chlorides (57)Sulfoxides (19)Tetrahydrofurans (12)Tetrahydroisoquinolines (3)Tetrahydropyrans (28)Tetrazoles (5)Thiadiazoles (17)Thiazoles (98)Thiazolidines (8)Thioesters (9)Thiols (8)Thiophenes (46)Thiophenols (29)Thioureas (28)Triazines (12)Triazoles (24)Trifluoromethyls (259)Ureas (28)Other Aliphatic Heterocycles (55)Other Aromatic Heterocycles (107)Acetylbenzonitrile (3)Aminobenzyl (4)Benzylamine (21)Benzylamino (47)Benzylhydroxylamine (25)Benzylidene (17)Benzyloxy (1048)Benzylthio (16)Cyanobenzyl (9)Dibenzyl (15)Dibenzylamino (7)Dichlorobenzylidene (7)Difluorobenzyl (17)Dimethoxybenzyl (20)Dimethylbenzonitrile (25)Dimethylbenzyl (6)Dimethylbenzylamine (6)Ethoxybenzyl (8)Fluorobenzyl (129)Fluorobenzylidene (2)Formylbenzonitrile (35)Iodobenzyl (8)Isopropylbenzonitrile (4)Methoxybenzyl (173)Methoxybenzylamine (7)Methoxybenzylidene (6)Methylbenzonitrile (104)Methylbenzyl (73)Methylbenzylamine (8)Methylbenzylidene (1)Nitrobenzyl (30)Nitrobenzylidene (2)Phenoxybenzonitrile (5)Trifluorobenzyl (2)(6-Phenoxytetrahydro-2H-Pyran-2-Yl)Methanol (16)(8S,9S,14R)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-3H-Cyclopenta[A]Phenanthren-3-One (1)(9H-Fluoren-9-Yl)Methyl (2-(Tritylthio)Ethyl)Carbamate (8)(9H-Fluoren-9-Yl)Methyl Cyclohexylcarbamate (8)(Benzylsulfonyl)Benzene (11)(Cyclopentyloxy)Benzene (12)1,1-Dimethylcyclopropane (5)1,3,4,5-Tetrahydro-2H-Benzo[B]Azepin-2-One (15)1,3-Diphenylurea (24)1-(2-Hydroxyphenyl)-2-Phenylethan-1-One (6)1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (11)1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One (5)1-(Naphthalen-2-Yl)Ethan-1-One (3)1-Benzyl-4-Chlorobenzene (6)1-Benzyl-4-Fluorobenzene (2)1-Bromonaphthalene (4)1-Chloronaphthalene (24)1-Fluoronaphthalene (23)1-Methoxynaphthalene (18)1-Methyl-4-(Phenylethynyl)Benzene (7)1-Methylnaphthalene (10)1-Naphthaldehyde (23)1-Naphthoic Acid (23)1-Nitronaphthalene (3)10H-Phenothiazine (20)2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl (4)2,5-Diphenylthiophene (5)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol (7)2-(Trifluoromethyl)-1,1'-Biphenyl (8)2-Benzylaniline (5)2-Bromo-1,1'-Biphenyl (12)2-Bromonaphthalene (4)2-Chloro-1,1'-Biphenyl (8)2-Chloronaphthalene (6)2-Ethoxynaphthalene (4)2-Fluorocyclopropane-1-Carboxylic Acid (7)2-Hydroxycyclohexa-2,5-Diene-1,4-Dione (3)2-Iodonaphthalene (5)2-Methoxy-1,1'-Biphenyl (7)2-Methoxynaphthalene (22)2-Methoxytetrahydro-2H-Pyran (9)2-Methyl-1,1'-Biphenyl (26)2-Methylnaphthalene (13)2-Naphthaldehyde (12)2-Naphthoic Acid (14)2-Naphthonitrile (15)2-Nitronaphthalene (4)2-Phenoxytetrahydro-2H-Pyran-4-Yl Acetate (6)2-Phenylnaphthalene (12)3,3'-Diphenyl-5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthalene (13)3,3-Diphenyl-3H-Benzo[C][1,2]Oxathiole 1,1-Dioxide (19)3-Bromo-1,1'-Biphenyl (12)3-Chloro-1,1'-Biphenyl (12)3-Fluoro-1,1'-Biphenyl (16)3-Methyl-1,1'-Biphenyl (10)3-Methyl-1,1':4',1''-Terphenyl (3)3-Phenethylphenol (5)3-Phenyl-1,2,4,5-Tetrazine (9)3-Styrylphenol (10)4-(Bromomethyl)-1,1'-Biphenyl (13)4-(Phenyldiazenyl)Benzoic Acid (4)4-(Phenylsulfonyl)Morpholine (14)4-(Tert-Butyl)-1,1'-Biphenyl (5)4-Cyclohexylphenol (7)4-Iodo-1,1'-Biphenyl (9)4-Methoxy-1,1'-Biphenyl (4)9H-Xanthene (7)[1,1'-Biphenyl]-2-Amine (8)[1,1'-Biphenyl]-2-Carbonitrile (12)[1,1'-Biphenyl]-2-Carboxylic Acid (24)[1,1'-Biphenyl]-2-Ol (16)[1,1'-Biphenyl]-3-Amine (11)[1,1'-Biphenyl]-3-Carbaldehyde (20)[1,1'-Biphenyl]-3-Carboxylic Acid (40)[1,1'-Biphenyl]-3-Ol (9)[1,1'-Biphenyl]-4-Carbaldehyde (31)[1,1'-Biphenyl]-4-Carbonitrile (27)[1,1'-Biphenyl]-4-Ol (29)[1,1'-Biphenyl]-4-Ylboronic Acid (29)Benzyltriphenylphosphonium (14)Cyclopentylbenzene (28)Cyclopropanecarboxylic Acid (11)Cyclopropyl(Phenyl)Methanamine (22)Cyclopropyl(Phenyl)Methanone (13)Diphenyl Phosphonate (11)Diphenylphosphane (25)Diphenylphosphine Oxide (27)Ethane-1,1-Diyldibenzene (3)Ethene-1,1,2-Triyltribenzene (14)Ethyl Cyclopropanecarboxylate (8)Methyl 1-Naphthoate (7)Methyl 2-Naphthoate (11)Methyl [1,1'-Biphenyl]-4-Carboxylate (7)Methyl Cyclopropanecarboxylate (8)N,1-Diphenylmethanimine (15)N,N-Dimethylnaphthalen-1-Amine (3)N-((5R,6R)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptan-6-Yl)-2-Phenylacetamide (5)N-Benzylbenzamide (21)N-Benzylbenzenesulfonamide (18)N-Cyclopropylbenzamide (14)N-Cyclopropylbenzenesulfonamide (10)N-Phenethylbenzamide (9)N-Phenyl-2-Naphthamide (11)Naphthalen-1-Ol (28)Naphthalen-1-Ylboronic Acid (4)Naphthalen-1-Ylmethanol (8)Naphthalen-2-Amine (12)Naphthalen-2-Ol (25)Naphthalen-2-Ylboronic Acid (8)Naphthalene-1,4-Diol (3)Naphthalene-2-Sulfonic Acid (4)Propane-2,2-Diyldibenzene (17)Tert-Butyl Cyclopropylcarbamate (7)Tetrahydro-2H-Pyran-2-Ol (12)Tetrahydro-2H-Pyran-2-Yl Acetate (12)Tetraphenylmethane (16)Triphenylene (12)Vinylcyclopropane (8)
Azides (42)
Azoes (112)
Aryls (12)(E)-1-(Naphthalen-1-Yl)-2-Phenyldiazene (7)1,2-Diphenyldiazene (7)3-(Phenyldiazenyl)Benzoic Acid (7)
Benzene Compounds (26341)
Acetamidophenyl (5)Acetylbenzoate (7)Acetylphenyl (10)Acetylphenylboronic (3)Aminobenzoyl (3)Aminobiphenyl (3)Aminonaphthalene (14)Aminophenoxy (19)Aminophenyl (222)Anisole (5)Anthracenes (138)Benzaldehyde (1582)Benzamidophenyl (1)Benzenedimethanol (4)Benzenethiol (8)Benzhydrylazetidine (10)Benzhydryloxy (4)Benziodoxol (2)Benzodioxole (9)Benzoquinone (6)Benzoylbenzoate (4)Benzoylphenyl (4)Binaphthalene (123)Biphenyl (1354)Boronophenyl (1)Bromobenzo (104)Bromobenzoyl (5)Bromodibenzo (9)Bromophenoxy (34)Bromophenyl (951)Butoxyphenyl (8)Butylaniline (7)Butylbenzene (16)Butyldiphenylsilyl (7)Butylphenol (18)Butylphenyl (32)Carbamoylphenoxy (11)Carbamoylphenyl (8)Carboxyphenyl (17)Chlorobenzenesulfonyl (23)Chlorobenzoyl (8)Chlorodibenzo (18)Chloronaphthalene (36)Chlorophenethyl (7)Chlorophenoxy (43)Chlorophenylacetate (4)Chlorophenylacetate Acid (9)Chlorophenylboronic (5)Cyclopropylaniline (6)Cyclopropylbenzoate (5)Cyclopropylnaphthalen (10)Cyclopropylphenyl (12)Diaminobenzene (7)Dibenzaldehyde (18)Dibenzene (7)Dibenzimidamide (4)Dibenzo (108)Dibenzoate (9)Dibenzonitrile (11)Dibromobenzene (45)Dibromobenzo (14)Dibromodibenzo (8)Dibromonaphthalene (15)Dibromophenanthrene (3)Dibromophenoxy (2)Dibromophenylboronic (3)Dichlorobenzene (38)Dichlorobenzoyl (4)Dichlorophenoxy (15)Dichlorophenyl (319)Dichlorophenylboronic (5)Didehydrodibenz (2)Diethoxyphenyl (10)Diethylaniline (6)Diethylbenzamide (7)Diethylbenzene (6)Difluorobenzene (57)Difluorobenzo (11)Difluorobenzoyl (9)Difluorophenoxy (9)Difluorophenyl (377)Difluorophenylboronic (11)Dihydroanthracene (1)Dihydrobenzo (187)Dihydrodibenzo (7)Dihydronaphthalene (104)Diiodobenzene (12)Diisopropylaniline (5)Diisopropylbenzamide (8)Diisopropylphenyl (39)Dimesityl (12)Dimethoxyacetophenone (5)Dimethoxyaniline (20)Dimethoxybenzaldehyde (40)Dimethoxybenzamide (6)Dimethoxybenzene (45)Dimethoxybenzo (4)Dimethoxybenzoate (19)Dimethoxybenzohydrazide (3)Dimethoxybenzonitrile (11)Dimethoxybenzoyl (4)Dimethoxybiphenyl (3)Dimethoxynaphthalene (10)Dimethoxyphenol (22)Dimethoxyphenyl (251)Dimethoxyphenylboronic (17)Dimethoxystyryl (4)Dimethylaminophenyl (4)Dimethylanthracene (4)Dimethylbenzaldehyde (27)Dimethylbenzamide (37)Dimethylbenzene (330)Dimethylbenzenesulfonamide (16)Dimethylbenzo (21)Dimethylbenzoate (27)Dimethylbenzoyl (3)Dimethylnaphthalene (6)Dimethylphenol (36)Dimethylphenoxy (13)Dimethylphenylboronic (6)Dimethylphenylhydrazine (3)Dimethylphenylisothiocyanate (4)Dinaphtho (5)Dinitrobenzene (20)Diphenol (30)Diphenylamino (26)Diphenylaniline (8)Diphenylethane (10)Diphenylethanone (5)Diphenylethene (6)Diphenylethyl (4)Diphenylmethyl (5)Diphenylmethylene (6)Diphenylphosphine (199)Diphenylpropane (18)Diphenylsilane (2)Diphenylurea (4)Ethoxyaniline (10)Ethoxybenzaldehyde (9)Ethoxybenzoate (12)Ethoxybenzonitrile (6)Ethoxyphenoxy (7)Ethoxyphenyl (44)Ethoxyphenylboronic (7)Ethylaniline (8)Ethylbenzenesulfonamide (318)Ethylbenzo (7)Ethylbenzoate (9)Ethylphenol (12)Ethylphenyl (39)Ethynylaniline (7)Ethynylbenzaldehyde (17)Ethynylphenyl (35)Fluorobenzeneboronic (24)Fluoronaphthalene (34)Fluorophenoxy (46)Formylbenzoate (39)Formylphenoxy (4)Formylphenyl (40)Formylphenylboronic (9)Hexahydrobenzo (3)Hexylphenyl (3)Homophenylalanine (16)Hydroxybenzenesulfonate (5)Hydroxybenzimidamide (11)Hydroxyisophthalaldehyde (6)Hydroxyphenethyl (2)Hydroxyphenyl (432)Iodobenzo (15)Iodobenzoic (54)Iodobenzoyl (6)Iodobiphenyl (24)Iododibenzo (7)Iodonaphthalene (9)Iodophenoxy (5)Isobutoxyphenyl (15)Isobutylbenzene (5)Isobutylphenyl (9)Isophthalate (8)Isophthalonitrile (4)Isopropoxyaniline (10)Isopropoxybenzaldehyde (7)Isopropoxybenzoate (7)Isopropoxyphenyl (40)Isopropylaniline (18)Isopropylbenzaldehyde (6)Isopropylbenzamide (9)Isopropylbenzenesulfonamide (19)Isopropylbenzoate (8)Isopropylphenyl (58)Mercaptobenzo (20)Methanobenzo (15)Methoxyacetophenone (12)Methoxyaniline (74)Methoxybenzaldehyde (103)Methoxybenzene (1685)Methoxybenzenesulfonamide (6)Methoxybenzenesulfonic (3)Methoxybenzenesulfonyl (13)Methoxybenzimidamide (5)Methoxybenzo (52)Methoxybenzoate (114)Methoxybenzonitrile (67)Methoxybenzoyl (11)Methoxycarbonylphenylboronic (5)Methoxynaphthalene (55)Methoxyphenol (71)Methoxyphenoxy (40)Methoxyphenylacetate (4)Methoxyphenylboronic (24)Methoxyphenylhydrazine (4)Methoxystyryl (12)Methylacetophenone (6)Methylaniline (182)Methylanisole (3)Methylanthracene (5)Methylbenzaldehyde (101)Methylbenzamide (87)Methylbenzamido (3)Methylbenzenesulfinamide (4)Methylbenzenesulfonamide (79)Methylbenzenesulfonic (9)Methylbenzenesulfonyl (4)Methylbenzimidamide (6)Methylbenzoate (193)Methylbenzohydrazide (6)Methylbenzothioamide (6)Methylbenzotrifluoride (5)Methylbenzoyl (23)Methylnaphthalene (34)Methylphenol (107)Methylphenoxy (18)Methylphenyl (524)Methylphenylacetonitrile (44)Methylphenylboronic (24)Methylphenylhydrazine (10)Methylpropiophenone (3)Naphthaldehyde (28)Naphthalene (442)Naphthaleneboronic (15)Naphthalenesulfonic (7)Naphthamide (15)Naphthonitrile (18)Nitrobenzenesulfonyl (8)Nitrobenzo (54)Nitrobenzoyl (12)Nitronaphthalene (23)Nitrophenoxy (43)Nitrophenyl (688)Nitrophenylboronic (14)Nitrotoluene (27)Octylbenzene (11)Paracyclophane (2)Pentafluorobenzene (13)Pentylbenzene (5)Pentylbenzoate (2)Pentylphenol (4)Pentylphenyl (5)Perfluorophenoxy (5)Perfluorophenyl (31)Phenoxyacetate (5)Phenoxyaniline (8)Phenoxybenzaldehyde (4)Phenoxybenzoate (5)Phenoxyethyl (4)Phenoxymethyl (7)Phenoxyphenyl (61)Phenoxypropan (4)Phenylacetamide (34)Phenylacetonitrile (7)Phenylacetyl (1)Phenylacrylamide (3)Phenylalaninol (2)Phenylamino (31)Phenylaniline (19)Phenylanthracene (16)Phenylbenzamide (23)Phenylbenzenesulfonamide (3)Phenylbutanoate (8)Phenylbutoxy (2)Phenylcarbamoyl (5)Phenylcyclohexanone (6)Phenylcyclopropanecarboxylic (6)Phenylcyclopropyl (7)Phenyldiazenyl (4)Phenylene (165)Phenylenediamine (13)Phenylenedimethanamine (5)Phenylethanamine (12)Phenylethane (9)Phenylethanol (8)Phenylethanone (19)Phenylethoxy (2)Phenylethyl (64)Phenylethylisocyanate (1)Phenylhex (3)Phenylimino (1)Phenylisocyanate (9)Phenylisoserine (4)Phenylmethanesulfonyl (2)Phenylmethoxy (4)Phenylmethyl (8)Phenylnaphthalene (6)Phenylpentan (10)Phenylpropanamide (11)Phenylpropyl (17)Phenylpyrazolo (8)Phenylsulfinyl (3)Phenylsulfonyl (88)Phenylthio (23)Phenylthiophene (21)Phenylthiourea (6)Phenylurea (3)Phenylvinyl (9)Phthalate (18)Phthalimide (12)Phthalonitrile (8)Propoxybenzaldehyde (4)Propoxyphenyl (29)Propoxyphenylboronic (79)Propylphenyl (26)Pyrenes (52)Quaternaphthalene (6)Quaterphenyl (15)Styryl (12)Sulfamoylphenyl (3)Sulfophenyl (4)Terephthalaldehyde (11)Terephthalate (13)Terphenyl (238)Tetraaniline (6)Tetrabenzaldehyde (7)Tetrafluorobenzene (16)Tetrahydrobenzo (64)Tetrahydronaphthalene (149)Tetralone (12)Tetramethylbenzene (9)Tetramethylbiphenyl (57)Tetraphenyl (11)Toluenesulfonyl (68)Tolyl (399)Tolylamino (3)Tolylazanediyl (4)Tolylethynyl (3)Tolyloxy (18)Tolylphosphine (8)Tolylthio (3)Trianiline (7)Tribenzaldehyde (5)Tribromobenzene (7)Trichlorobenzene (19)Trichlorophenoxy (3)Trichlorophenylboronic (6)Triethylbenzene (5)Trifluorophenyl (52)Trifluorophenylboronic (154)Triiodobenzene (5)Triisopropylbenzene (9)Triisopropylphenyl (6)Trimethoxybenzene (43)Trimethoxystyryl (5)Trimethylaniline (18)Trimethylbenzene (28)Trimethylphenol (7)Trimethylphenyl (20)Trimethylpropiophenone (4)Triphenylphosphoranylidene (9)Triphenylvinyl (11)Trityl (19)Tritylamino (2)Trityloxy (2)Tritylthio (3)(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid (3)(10Ar)-1,2,3,4,4A,9,10,10A-Octahydrophenanthrene (2)(1E,1'E)-N,N'-(Ethane-1,2-Diyl)Bis(1-Phenylmethanimine) (5)(1R,4R)-4-Phenyl-1,1'-Bi(Cyclohexane) (24)(9H-Fluoren-9-Yl)Methyl Benzylcarbamate (22)(9H-Fluoren-9-Yl)Methyl Piperazine-1-Carboxylate (7)(Cyclopentylmethyl)Benzene (5)(R)-3-Benzylpyrrolidine (6)(R)-3-Phenylmorpholine (7)(R)-N-(1,2-Diphenylethyl)Benzenesulfonamide (1)(S)-N-(1,2-Diphenylethyl)Benzenesulfonamide (1)1,1':2',1''-Terphenyl (4)1,1':3',1''-Terphenyl (28)1,1':4',1'':4'',1'''-Quaterphenyl (7)1,1,2,2-Tetra([1,1'-Biphenyl]-4-Yl)Ethene (10)1,1-Dimethyl-1,2,3,4-Tetrahydronaphthalene (10)1,2,3,4-Tetrahydronaphthalen-1-Amine (36)1,2,3,4-Tetrahydronaphthalen-1-Ol (5)1,2,3,4-Tetrahydronaphthalene-1-Carboxylic Acid (3)1,2,3,5,6,7-Hexahydro-S-Indacene (23)1,2,4-Trimethylbenzene (41)1,2-Dihydroacenaphthylene (6)1,2-Dinitrobenzene (6)1,3,5-Tris(Phenylethynyl)Benzene (6)1,3,6,8-Tetraphenylpyrene (10)1,3-Bis(Benzyloxy)Benzene (8)1,3-Dihydro-2H-Inden-2-One (6)1,3-Diphenoxypropane (6)1,3-Diphenyl-1H-Pyrazole (5)1,3-Diphenylpropane (6)1,3-Diphenylpropane-1,3-Dione (3)1,4-Bis(Phenylethynyl)Benzene (7)1,4-Diphenylbuta-1,3-Diyne (9)1-(2,3-Dihydro-1H-Inden-5-Yl)Ethan-1-Amine (3)1-(Anthracen-9-Yl)Ethan-1-Amine (3)1-Benzylazetidine (6)1-Bromopyrene (4)1-Cyclohexyl-4-(Phenylethynyl)Benzene (10)1-Cyclopropylnaphthalene (6)1-Phenyl-1H-Tetrazole (6)1-Phenylnaphthalene (12)1-Trityl-1H-Pyrazole (5)1H-Indene (18)1H-Indene-1,3(2H)-Dione (5)2,2 ', 3,3' - Tetrahydro-1,1 '- Spiro [Indene] (5)2,3,4,5-Tetrahydro-1H-Benzo[C]Azepine (7)2,3-Dihydro-1H-Inden-1-Amine (52)2,3-Dihydro-1H-Inden-1-Ol (13)2,3-Dihydro-1H-Inden-4-Amine (6)2,3-Dihydro-1H-Inden-4-Ol (6)2,3-Dihydro-1H-Indene-1-Carboxylic Acid (5)2,3-Dihydro-1H-Indene-4-Carbonitrile (4)2,4-Diphenyl-1,3,5-Triazine (6)2,5-Diphenyl-1,3,4-Oxadiazole (6)2,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-9H-Fluorene (7)2-(2-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (24)2-(2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (21)2-(2-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (29)2-(3-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (14)2-(3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (19)2-(3-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (30)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (17)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde (20)2-(4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (15)2-(4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (16)2-Amino-2-(Anthracen-9-Yl)Ethan-1-Ol (4)2-Methyl-2,3-Dihydro-1H-Inden-1-One (9)2-Phenyl-1,3,5-Triazine (6)2-Phenyl-1,3-Dioxane (7)2-Phenyl-2H-1,2,3-Triazole (7)2-Phenylisoindoline-1,3-Dione (7)2H-Benzo[B][1,4]Thiazin-3(4H)-One (6)3,3-Dimethyl-2,3-Dihydro-1H-Inden-1-One (5)3,4-Dihydro-2H-Benzo[B][1,4]Dioxepine (7)3,5,6,7-Tetrahydro-S-Indacen-1(2H)-One (5)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2-Bromophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(2-Chlorophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-(Trifluoromethyl)Phenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-Fluorophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-Methoxyphenyl)Propanoic Acid (4)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(3-Nitrophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Bromophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(4-Nitrophenyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(O-Tolyl)Propanoic Acid (3)3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-(P-Tolyl)Propanoic Acid (3)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (25)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde (19)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoic Acid (12)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol (13)3-Methyl-2,3-Dihydro-1H-Inden-1-One (4)3-Phenyl-1H-Pyrrole (4)3-Phenyloxazolidin-2-One (4)4',5'-Diphenyl-1,1':2',1''-Terphenyl (7)4,4,5,5-Tetramethyl-2-(3-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane (19)4,4,5,5-Tetramethyl-2-(3-Nitrophenyl)-1,3,2-Dioxaborolane (24)4,4,5,5-Tetramethyl-2-(M-Tolyl)-1,3,2-Dioxaborolane (21)4,4,5,5-Tetramethyl-2-(O-Tolyl)-1,3,2-Dioxaborolane (24)4,5-Diphenyloxazole (7)4,7-Diphenylbenzo[C][1,2,5]Thiadiazole (6)4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazole (7)4-(Phenylethynyl)-1,1'-Biphenyl (5)4-Bromo-2,3-Dihydro-1H-Inden-1-One (5)4-Bromo-2,3-Dihydro-1H-Indene (10)4-Chloro-2,3-Dihydro-1H-Inden-1-One (8)4-Chloro-2,3-Dihydro-1H-Indene (5)4-Cyclohexyl-1,1'-Biphenyl (18)4-Fluoro-2,3-Dihydro-1H-Inden-1-One (6)4-Fluoro-2,3-Dihydro-1H-Indene (14)4-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)4-Methyl-2,3-Dihydro-1H-Inden-1-One (8)4-Methyl-2,3-Dihydro-1H-Indene (3)4-Phenyl-1,1'-Bi(Cyclohexane) (8)4-Phenyl-4H-1,2,4-Triazole (6)5''-([1,1'-Biphenyl]-4-Yl)-1,1':4',1'':3'',1''':4''',1''''-Quinquephenyl (5)5',5''-Diphenyl-1,1':3',1'':3'',1'''-Quaterphenyl (8)5,5',6,6',7,7',8,8'-Octahydro-1,1'-Binaphthalene (6)5,6,7,8-Tetrahydronaphthalen-2-Ol (5)5-Bromo-1,2,3,4-Tetrahydronaphthalene (6)5-Bromo-2,3-Dihydro-1H-Indene (8)5-Fluoro-2,3-Dihydro-1H-Indene (3)5-Methoxy-1,2,3,4-Tetrahydronaphthalene (3)5-Methoxy-2,3-Dihydro-1H-Indene (2)5-Methyl-3,4-Dihydronaphthalen-1(2H)-One (6)5-Phenyl-1H-Imidazole (6)5-Phenylcyclohexane-1,3-Dione (6)6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-5-One (6)6-Bromo-1,2,3,4-Tetrahydronaphthalene (9)6-Bromo-2,3-Dihydro-1H-Inden-1-One (8)6-Bromo-3,4-Dihydronaphthalen-1(2H)-One (3)6-Chloro-1,2,3,4-Tetrahydronaphthalene (3)6-Chloro-2,3-Dihydro-1H-Inden-1-One (5)6-Fluoro-1,2,3,4-Tetrahydronaphthalene (6)6-Fluoro-2,3-Dihydro-1H-Inden-1-One (4)6-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (5)6-Methyl-1,2,3,4-Tetrahydronaphthalene (5)6-Methyl-2,3-Dihydro-1H-Inden-1-One (3)6-Methyl-3,4-Dihydronaphthalen-1(2H)-One (2)7-Bromo-2,3-Dihydro-1H-Inden-1-One (13)7-Chloro-2,3-Dihydro-1H-Inden-1-One (9)7-Fluoro-2,3-Dihydro-1H-Inden-1-One (8)7-Hydroxy-2,3-Dihydro-1H-Inden-1-One (6)7-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (6)7-Methyl-2,3-Dihydro-1H-Inden-1-One (7)9,10-Bis(Phenylethynyl)Anthracene (5)9,10-Diphenylanthracene (15)9-Methylanthracene (4)9-Phenylxanthylium (7)9H-Fluoren-9-One (17)[1,1'-Binaphthalen]-2-Amine (3)[1,1':4',1''-Terphenyl]-4,4''-Dicarbaldehyde (9)Benzenesulfinic Acid (6)Benzil (17)Benzo-18-Crown-6 (7)Benzo[Lmn][3,8]Phenanthroline-1,3,6,8(2H,7H)-Tetraone (10)Benzyl ((Benzyloxy)Carbonyl)Glycinate (8)Benzyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate (5)Benzyl (S)-Pyrrolidin-3-Ylcarbamate (7)Benzyl 3-Phenylpropanoate (1)Benzyl Piperidin-4-Ylcarbamate (7)Bicyclo[4.2.0]Octa-1,3,5-Triene (13)Cumene (181)Dibenzyl Phosphonate (6)Diphenylmethanimine (9)Ethane-1,1,2-Triyltribenzene (4)Ethylbenzene (197)Mesitylene (71)Methyl 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (14)Methyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (11)N,2-Diphenylacetamide (7)N,N,N-Trimethyl-1-Phenylmethanaminium (6)N,N-Diphenyl-[1,1'-Biphenyl]-4-Amine (8)N-Benzyl-2-Phenylethan-1-Amine (1)N-Benzylcyclopropanamine (6)N-Phenylcinnamamide (16)N1,N1,N4,N4-Tetraphenylbenzene-1,4-Diamine (6)N4,N4,N4',N4'-Tetraphenyl-[1,1'-Biphenyl]-4,4'-Diamine (6)Phenanthrene (26)Phenanthrene-9,10-Dione (8)Phenethyldiphenylphosphane (6)Phenothiazin-5-Ium (6)Phenyl (1R,4R)-[1,1'-Bi(Cyclohexane)]-4-Carboxylate (6)Phenyl 4-Cyclohexylbenzoate (8)Tert-Butyl (2,3-Dihydro-1H-Inden-1-Yl)Carbamate (3)Tert-Butylbenzene (243)Triphenyl Phosphate (6)
Benzyl Bromides (1076)
Amides (6)Aryls (82)Bromides (81)Chlorides (6)Esters (14)Ethers (6)Fluorinated Building Blocks (2)Nitriles (5)Sulfamides (3)1-(Bromomethyl)-2-(Trifluoromethyl)Benzene (13)1-(Bromomethyl)-2-Chlorobenzene (28)1-(Bromomethyl)-2-Fluorobenzene (50)1-(Bromomethyl)-3-(Trifluoromethyl)Benzene (17)1-(Bromomethyl)-3-Chlorobenzene (27)1-(Bromomethyl)-3-Fluorobenzene (47)1-(Bromomethyl)-3-Methoxybenzene (19)1-Bromo-2-(Bromomethyl)Benzene (34)2-(2-(Bromomethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (9)2-(Bromomethyl)-1,3-Difluorobenzene (12)2-(Bromomethyl)Benzonitrile (14)Methyl 2-(Bromomethyl)Benzoate (33)
Benzyl Chlorides (667)
Alkenyls (1)Amides (8)Aryls (53)Bromides (5)Chlorides (49)Esters (10)Ethers (7)Fluorinated Building Blocks (2)Dichlorobenzyl (39)1-(Chloromethyl)-2-Fluorobenzene (8)1-(Chloromethyl)-3-Fluorobenzene (11)
Bromides (52709)
Acyl Chlorides (5)Alcohols (147)Aldehydes (78)Aliphatic Chain Hydrocarbons (148)Aliphatic Cyclic Hydrocarbons (31)Alkenyls (45)Alkynyls (11)Amides (309)Amines (216)Anhydrides (5)Aryls (934)Azetidines (7)Benzimidazoles (8)Benzofurans (18)Benzothiazoles (11)Benzothiophenes (4)Benzoxazoles (10)Benzyl Bromides (81)Benzyl Chlorides (5)Carboxylic Acids (176)Chlorides (241)Difluoromethyls (36)Dioxolanes (6)Esters (313)Ethers (328)Fluorinated Building Blocks (304)Furans (13)Imidazoles (16)Indazoles (25)Indoles (35)Indolines (16)Iodides (54)Isoquinolines (11)Isothiazoles (4)Isoxazoles (11)Ketones (168)Morpholines (30)Naphthyridines (4)Nitriles (82)Nitroes (62)Oxadiazoles (4)Oxazoles (12)Oxetanes (9)Phenols (34)Piperazines (8)Piperidines (31)Pyrazines (9)Pyrazoles (38)Pyridazines (10)Pyridines (398)Pyrimidines (71)Pyrroles (5)Pyrrolidines (25)Pyrrolines (6)Quinazolines (13)Quinolines (106)Quinoxalines (9)Spiroes (11)Sulfamides (35)Sulfides (18)Sulfones (31)Sulfonyl Chlorides (17)Tetrahydrofurans (4)Tetrahydropyrans (6)Tetrahydroquinolines (6)Thiazoles (70)Thiophenes (66)Thiophenols (4)Trifluoromethyls (94)Other Aromatic Heterocycles (91)Bromo-Carbazole (1)Bromoacetyl (14)Bromoaniline (2)Bromoanthracene (5)Bromobenzaldehyde (15)Bromobenzamide (7)Bromobenzimidamide (6)Bromobenzyl (31)Bromobut (2)Bromobutoxy (4)Bromobutyl (6)Bromochroman (25)Bromoethoxy (22)Bromoethyl (86)Bromoethynyl (6)Bromohexyl (11)Bromomethyl (758)Bromonicotinaldehyde (5)Bromonicotinamide (5)Bromooctyl (3)Bromopentyl (8)Bromopropane (10)Bromopropoxy (6)Bromopropyl (25)Bromothiochroman (4)Bromovinyl (2)Dibromo (691)Dibromoanthracene (3)Dibromobenzaldehyde (8)Dibromobenzonitrile (8)Dibromomethyl (6)Tetrabromo (10)Tribromo (9)(1-Bromoethyl)Benzene (11)(2,2-Dibromovinyl)Benzene (6)(2-(4-Bromophenyl)Ethene-1,1,2-Triyl)Tribenzene (11)(2-Bromo-6-Fluorophenyl)Methanol (4)(2-Bromoethyl)Benzene (33)(2-Bromophenyl)(Phenyl)Methanone (3)(2-Bromophenyl)Boronic Acid (39)(2-Bromophenyl)Hydrazine (8)(2-Bromophenyl)Methanamine (12)(2-Bromophenyl)Methanol (39)(3-Bromo-2-Fluorophenyl)Boronic Acid (7)(3-Bromo-2-Methoxyphenyl)Boronic Acid (6)(3-Bromophenyl)Boronic Acid (65)(3-Bromopropyl)Benzene (10)(3-Bromopyridin-2-Yl)Methanol (7)(4-Bromophenyl)(Phenyl)Methanone (9)(5-Bromopyridin-2-Yl)Methanamine (5)(5-Bromopyridin-2-Yl)Methanol (5)(Bromoethynyl)Benzene (5)(Dibromomethyl)Benzene (6)1,2,3-Tribromobenzene (4)1,2,4-Tribromobenzene (12)1,2-Dibromo-3-Chlorobenzene (3)1,2-Dibromo-3-Fluorobenzene (8)1,2-Dibromo-3-Methylbenzene (9)1,2-Dibromo-4-Fluorobenzene (11)1,2-Dibromobenzene (62)1,3-Dibromo-2,4-Difluorobenzene (5)1,3-Dibromo-2,4-Dimethylbenzene (3)1,3-Dibromo-2-Chlorobenzene (8)1,3-Dibromo-2-Fluorobenzene (15)1,3-Dibromo-2-Iodobenzene (4)1,3-Dibromo-2-Methoxybenzene (11)1,3-Dibromo-2-Methylbenzene (14)1,3-Dibromo-2-Nitrobenzene (4)1,4-Dibromo-2-Iodobenzene (3)1-(2-Bromophenyl)Ethan-1-Amine (10)1-(2-Bromophenyl)Ethan-1-One (27)1-(5-Bromopyridin-2-Yl)Piperazine (6)1-(Azetidin-1-Yl)-2-Bromoethan-1-One (3)1-(Benzyloxy)-2-Bromobenzene (12)1-(Benzyloxy)-3-Bromobenzene (12)1-(Benzyloxy)-4-Bromobenzene (8)1-(Bromomethyl)-2-Iodobenzene (9)1-(Bromomethyl)-2-Methoxybenzene (14)1-(Bromomethyl)-2-Methylbenzene (14)1-(Bromomethyl)-2-Nitrobenzene (23)1-(Bromomethyl)-3-Methylbenzene (11)1-Benzyl-3-Bromobenzene (7)1-Benzyl-4-Bromo-1H-Pyrazole (5)1-Bromo-2,3-Dichlorobenzene (18)1-Bromo-2,3-Difluorobenzene (67)1-Bromo-2,3-Dimethoxybenzene (8)1-Bromo-2,3-Dimethylbenzene (23)1-Bromo-2,4-Difluorobenzene (59)1-Bromo-2-(Bromomethyl)Benzene (34)1-Bromo-2-(Difluoromethyl)Benzene (5)1-Bromo-2-(Methylsulfonyl)Benzene (4)1-Bromo-2-(Tert-Butyl)Benzene (7)1-Bromo-2-(Trifluoromethoxy)Benzene (22)1-Bromo-2-Chloro-3-Fluorobenzene (20)1-Bromo-2-Chloro-3-Methoxybenzene (6)1-Bromo-2-Chloro-3-Methylbenzene (9)1-Bromo-2-Chloro-4-Nitrobenzene (5)1-Bromo-2-Cyclopropylbenzene (3)1-Bromo-2-Ethoxybenzene (16)1-Bromo-2-Ethylbenzene (13)1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene (4)1-Bromo-2-Fluoro-3-Methoxybenzene (7)1-Bromo-2-Fluoro-3-Methylbenzene (11)1-Bromo-2-Fluoro-3-Nitrobenzene (11)1-Bromo-2-Fluoro-4-Nitrobenzene (13)1-Bromo-2-Iodobenzene (65)1-Bromo-2-Isopropylbenzene (10)1-Bromo-2-Phenoxybenzene (3)1-Bromo-3-(Trifluoromethyl)Benzene (100)1-Bromo-3-Chloro-2-Fluorobenzene (9)1-Bromo-3-Chloro-2-Methylbenzene (6)1-Bromo-3-Cyclopropylbenzene (6)1-Bromo-3-Fluoro-2-Iodobenzene (4)1-Bromo-3-Fluoro-2-Methoxybenzene (12)1-Bromo-3-Fluoro-2-Methylbenzene (17)1-Bromo-3-Fluoro-2-Nitrobenzene (10)1-Bromo-3-Iodobenzene (71)1-Bromo-3-Methoxybenzene (186)1-Bromo-3-Methyl-2-Nitrobenzene (3)1-Bromo-3-Nitrobenzene (235)1-Bromo-3-Phenoxybenzene (8)1-Bromo-4-(Phenylsulfonyl)Benzene (7)1-Bromo-4-Chloro-2-Fluorobenzene (21)1-Bromo-4-Fluoro-2-Methoxybenzene (11)1-Bromo-4-Fluoro-2-Methylbenzene (18)1-Bromo-4-Iodobenzene (67)1-Bromo-4-Phenoxybenzene (8)1-Bromo-4-Styrylbenzene (5)1-Bromobicyclo[1.1.1]Pentane (3)1-Bromoisoquinoline (20)1-Bromonaphthalene (4)2,3-Dibromopyridine (21)2,4-Dibromo-1-Chlorobenzene (8)2,4-Dibromo-1-Fluorobenzene (18)2,4-Dibromo-1-Methoxybenzene (6)2,4-Dibromoaniline (18)2,4-Dibromophenol (16)2,4-Dibromopyridine (5)2,4-Dibromothiazole (5)2,5-Dibromopyrazine (4)2,5-Dibromopyridine (26)2,5-Dibromothiazole (5)2,5-Dibromothiophene (18)2,6-Dibromo-3-Fluoropyridine (3)2,6-Dibromoaniline (17)2,6-Dibromobenzaldehyde (4)2,6-Dibromobenzonitrile (4)2,6-Dibromophenol (20)2,6-Dibromopyrazine (9)2,6-Dibromopyridin-4-Amine (3)2,6-Dibromopyridine (28)2-(2-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(2-Bromophenyl)Acetic Acid (23)2-(2-Bromophenyl)Acetonitrile (10)2-(4-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(Bromomethyl)Furan (3)2-(Bromomethyl)Pyridine (27)2-Amino-3-Bromobenzoic Acid (8)2-Amino-3-Bromobenzonitrile (7)2-Amino-3-Bromophenol (3)2-Amino-6-Bromophenol (3)2-Bromo-1,1'-Biphenyl (12)2-Bromo-1,3,4-Thiadiazole (11)2-Bromo-1,3,4-Trifluorobenzene (16)2-Bromo-1,3,4-Trimethylbenzene (4)2-Bromo-1,3-Dichlorobenzene (12)2-Bromo-1,3-Difluorobenzene (43)2-Bromo-1,3-Dimethoxybenzene (7)2-Bromo-1,3-Dimethylbenzene (35)2-Bromo-1,4-Dichlorobenzene (12)2-Bromo-1,4-Difluorobenzene (64)2-Bromo-1,4-Dimethoxybenzene (10)2-Bromo-1,4-Dimethylbenzene (22)2-Bromo-1-Chloro-3-Fluorobenzene (9)2-Bromo-1-Chloro-4-Fluorobenzene (20)2-Bromo-1-Chloro-4-Methylbenzene (6)2-Bromo-1-Chloro-4-Nitrobenzene (9)2-Bromo-1-Fluoro-3-Nitrobenzene (9)2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene (4)2-Bromo-1-Fluoro-4-Methoxybenzene (12)2-Bromo-1-Fluoro-4-Methylbenzene (17)2-Bromo-1-Fluoro-4-Nitrobenzene (23)2-Bromo-1-Methoxy-3-Methylbenzene (3)2-Bromo-1-Methoxy-4-Methylbenzene (7)2-Bromo-1-Methyl-4-Nitrobenzene (12)2-Bromo-1H-Benzo[D]Imidazole (4)2-Bromo-1H-Imidazole (13)2-Bromo-1H-Pyrrole (11)2-Bromo-3-(Trifluoromethyl)Pyridine (4)2-Bromo-3-Chloroaniline (4)2-Bromo-3-Chloropyridine (25)2-Bromo-3-Fluoroaniline (13)2-Bromo-3-Fluoropyridine (26)2-Bromo-3-Hydroxybenzaldehyde (4)2-Bromo-3-Methoxybenzaldehyde (4)2-Bromo-3-Methoxypyridine (7)2-Bromo-3-Methylaniline (6)2-Bromo-3-Methylphenol (4)2-Bromo-3-Methylpyrazine (5)2-Bromo-3-Methylpyridine (25)2-Bromo-3-Nitrobenzoic Acid (4)2-Bromo-3-Nitropyridine (5)2-Bromo-4-(Trifluoromethyl)Aniline (9)2-Bromo-4-Chloro-1-Fluorobenzene (16)2-Bromo-4-Chloro-1-Methoxybenzene (7)2-Bromo-4-Chloro-1-Methylbenzene (11)2-Bromo-4-Chloro-1-Nitrobenzene (5)2-Bromo-4-Chloroaniline (15)2-Bromo-4-Chlorophenol (11)2-Bromo-4-Chloropyridine (7)2-Bromo-4-Fluoro-1-Methoxybenzene (12)2-Bromo-4-Fluoro-1-Methylbenzene (21)2-Bromo-4-Fluoro-1-Nitrobenzene (23)2-Bromo-4-Fluoroaniline (28)2-Bromo-4-Fluorobenzaldehyde (7)2-Bromo-4-Fluorobenzoic Acid (8)2-Bromo-4-Fluorobenzonitrile (7)2-Bromo-4-Fluorophenol (10)2-Bromo-4-Methoxy-1-Nitrobenzene (6)2-Bromo-4-Methoxyaniline (6)2-Bromo-4-Methoxybenzaldehyde (8)2-Bromo-4-Methoxybenzoic Acid (4)2-Bromo-4-Methylaniline (14)2-Bromo-4-Methylbenzoic Acid (5)2-Bromo-4-Methylpyridine (6)2-Bromo-4-Methylthiazole (7)2-Bromo-4-Nitroaniline (12)2-Bromo-5-(Trifluoromethyl)Pyridine (6)2-Bromo-5-Chloropyrazine (6)2-Bromo-5-Chloropyridine (22)2-Bromo-5-Fluoroaniline (18)2-Bromo-5-Fluorobenzaldehyde (7)2-Bromo-5-Fluorobenzoic Acid (11)2-Bromo-5-Fluoropyridine (33)2-Bromo-5-Methoxybenzaldehyde (6)2-Bromo-5-Methoxypyridine (11)2-Bromo-5-Methylpyridine (19)2-Bromo-5-Methylthiazole (7)2-Bromo-5-Nitropyridine (11)2-Bromo-6-(Trifluoromethyl)Aniline (5)2-Bromo-6-(Trifluoromethyl)Pyridine (6)2-Bromo-6-Chloroaniline (10)2-Bromo-6-Chlorophenol (5)2-Bromo-6-Chloropyrazine (5)2-Bromo-6-Chloropyridine (23)2-Bromo-6-Fluoroaniline (14)2-Bromo-6-Fluorobenzaldehyde (15)2-Bromo-6-Fluorobenzoic Acid (11)2-Bromo-6-Fluorobenzonitrile (7)2-Bromo-6-Fluorophenol (9)2-Bromo-6-Fluoropyridine (21)2-Bromo-6-Iodoaniline (4)2-Bromo-6-Methoxyaniline (5)2-Bromo-6-Methoxyphenol (5)2-Bromo-6-Methoxypyridine (15)2-Bromo-6-Methylaniline (11)2-Bromo-6-Methylbenzoic Acid (5)2-Bromo-6-Methylphenol (7)2-Bromo-6-Methylpyrazine (5)2-Bromo-6-Methylpyridine (17)2-Bromo-6-Nitroaniline (14)2-Bromo-6-Nitrophenol (9)2-Bromo-6-Phenylpyridine (4)2-Bromo-9,9-Diphenyl-9H-Fluorene (5)2-Bromo-9H-Fluorene (15)2-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)2-Bromo-N,N-Dimethylaniline (5)2-Bromo-N-Methylaniline (8)2-Bromo-N-Phenylacetamide (5)2-Bromobenzene-1,3-Diol (7)2-Bromobenzene-1,4-Diol (4)2-Bromobenzenesulfonyl Chloride (8)2-Bromobenzo[D]Thiazole (28)2-Bromodibenzo[B,D]Furan (6)2-Bromofuran (21)2-Bromoimidazo[1,2-A]Pyridine (5)2-Bromonaphthalene (4)2-Bromonicotinic Acid (5)2-Bromooxazole (7)2-Bromopyrazine (15)2-Bromopyridin-3-Amine (10)2-Bromopyridin-3-Ol (7)2-Bromopyridine (10)2-Bromopyridine 1-Oxide (6)2-Bromopyrimidine (22)2-Bromoquinazoline (4)3,4-Dibromoaniline (4)3,4-Dibromophenol (3)3,5-Dibromopyridine (12)3-(Bromomethyl)Pyridine (18)3-Bromo-1,1'-Biphenyl (12)3-Bromo-1,5-Naphthyridine (8)3-Bromo-1-Methyl-1H-Pyrazole (16)3-Bromo-1H-Pyrrole (16)3-Bromo-1H-Pyrrolo[2,3-B]Pyridine (7)3-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Bromo-2-Chlorobenzaldehyde (4)3-Bromo-2-Chlorobenzoic Acid (7)3-Bromo-2-Chloropyridin-4-Amine (3)3-Bromo-2-Chloropyridine (20)3-Bromo-2-Fluoroaniline (15)3-Bromo-2-Fluorobenzaldehyde (9)3-Bromo-2-Fluorobenzoic Acid (10)3-Bromo-2-Fluorobenzonitrile (10)3-Bromo-2-Fluorophenol (5)3-Bromo-2-Fluoropyridine (21)3-Bromo-2-Hydroxybenzaldehyde (10)3-Bromo-2-Hydroxybenzoic Acid (4)3-Bromo-2-Hydroxybenzonitrile (3)3-Bromo-2-Methoxypyridine (20)3-Bromo-2-Methylpyridine (27)3-Bromo-4-Chloroaniline (13)3-Bromo-4-Chlorobenzoic Acid (6)3-Bromo-4-Chlorophenol (5)3-Bromo-4-Fluoroaniline (22)3-Bromo-4-Fluorobenzaldehyde (7)3-Bromo-4-Fluorobenzamide (3)3-Bromo-4-Fluorobenzoic Acid (10)3-Bromo-4-Fluorophenol (11)3-Bromo-4-Hydroxybenzaldehyde (9)3-Bromo-4-Hydroxybenzoic Acid (3)3-Bromo-4-Methoxyaniline (7)3-Bromo-4-Methoxybenzaldehyde (9)3-Bromo-4-Methoxybenzoic Acid (7)3-Bromo-4-Methylaniline (14)3-Bromo-4-Methylbenzoic Acid (9)3-Bromo-4-Methylpyridine (13)3-Bromo-5'-Phenyl-1,1':3',1''-Terphenyl (4)3-Bromo-5-Chloropyridine (14)3-Bromo-5-Fluoropyridine (18)3-Bromo-5-Methylpyridine (14)3-Bromo-5-Nitropyridine (10)3-Bromoaniline (187)3-Bromoazetidine (3)3-Bromobenzene-1,2-Diamine (11)3-Bromobenzene-1,2-Diol (8)3-Bromobenzo[B]Thiophene (5)3-Bromobenzoic Acid (159)3-Bromobenzonitrile (109)3-Bromofuran (13)3-Bromoimidazo[1,2-A]Pyridine (26)3-Bromoimidazo[1,2-A]Pyrimidine (6)3-Bromoisoquinoline (10)3-Bromoisoxazole (7)3-Bromopicolinic Acid (9)3-Bromopicolinonitrile (13)3-Bromopyrazolo[1,5-A]Pyrimidine (11)3-Bromopyridazine (25)3-Bromopyridin-2-Amine (30)3-Bromopyridin-2-Ol (17)3-Bromopyridine 1-Oxide (8)3-Bromopyrrolidine (6)3-Bromothiophene (6)4-(Bromomethyl)-1,1'-Biphenyl (13)4-(Bromomethyl)Pyridine (8)4-Bromo-1,5-Naphthyridine (5)4-Bromo-1-Methyl-1H-Pyrazole (14)4-Bromo-1-Phenyl-1H-Imidazole (9)4-Bromo-1-Phenyl-1H-Pyrazole (11)4-Bromo-1H-Benzo[D]Imidazole (14)4-Bromo-1H-Indole (25)4-Bromo-1H-Pyrazolo[3,4-B]Pyridine (4)4-Bromo-1H-Pyrrolo[2,3-B]Pyridine (9)4-Bromo-2-Chloro-1-Iodobenzene (4)4-Bromo-2-Chloropyridine (29)4-Bromo-2-Fluoro-1-Iodobenzene (8)4-Bromo-2-Fluoropyridine (4)4-Bromo-2-Iodoaniline (8)4-Bromo-2-Methoxypyridine (4)4-Bromo-3-(Trifluoromethyl)Aniline (7)4-Bromo-3-Chloroaniline (21)4-Bromo-3-Fluoroaniline (29)4-Bromo-3-Methylaniline (19)4-Bromo-3-Methylpyridine (5)4-Bromo-3-Nitroaniline (8)4-Bromo-N,N-Diphenylaniline (10)4-Bromo-N-Phenylaniline (6)4-Bromo-N-Phenylbenzenesulfonamide (23)4-Bromobenzo[C][1,2,5]Thiadiazole (12)4-Bromobenzo[D][1,3]Dioxole (6)4-Bromobenzo[D]Thiazole (9)4-Bromobenzofuran (3)4-Bromoindoline (4)4-Bromoisoindolin-1-One (3)4-Bromoisoquinolin-1(2H)-One (3)4-Bromoisoquinoline (33)4-Bromopyridazine (5)4-Bromopyridine (31)4-Bromopyrimidine (24)4-Bromothiazole (10)5-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)5-Bromo-1-Methyl-1H-Indole (3)5-Bromo-1H-1,2,4-Triazole (6)5-Bromo-1H-Benzo[D][1,2,3]Triazole (5)5-Bromo-1H-Benzo[D]Imidazole (13)5-Bromo-1H-Indazole (12)5-Bromo-1H-Pyrazole (11)5-Bromo-1H-Pyrazolo[3,4-B]Pyridine (11)5-Bromo-1H-Pyrazolo[3,4-C]Pyridine (5)5-Bromo-1H-Pyrrolo[2,3-B]Pyridine (13)5-Bromo-2,3-Dihydro-1H-Indene (8)5-Bromo-2,3-Dihydrobenzofuran (6)5-Bromo-2-Chloro-4-Methylpyridine (5)5-Bromo-2-Chloropyridine (40)5-Bromo-2-Chloropyrimidine (6)5-Bromo-2-Fluoropyridine (22)5-Bromo-2-Methoxypyridine (29)5-Bromo-2-Methylpyridine (23)5-Bromo-2-Methylpyrimidine (5)5-Bromo-2-Phenylpyridine (3)5-Bromo-4-Methylpyridin-2-Amine (5)5-Bromo-6-Chloropyridin-2-Amine (3)5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine (3)5-Bromobenzo[B]Thiophene (3)5-Bromobenzo[D][1,3]Dioxole (12)5-Bromobenzo[D]Oxazole (3)5-Bromoimidazo[1,2-A]Pyridine (6)5-Bromoindoline (8)5-Bromoisoindolin-1-One (8)5-Bromoisoquinoline (17)5-Bromonicotinaldehyde (12)5-Bromonicotinic Acid (6)5-Bromonicotinonitrile (6)5-Bromopicolinic Acid (11)5-Bromopicolinonitrile (13)5-Bromopyrazin-2-Ol (5)5-Bromopyridin-2-Amine (35)5-Bromopyridin-2-Ol (18)5-Bromopyridin-3-Amine (10)5-Bromopyridin-3-Ol (6)5-Bromoquinoxaline (6)5-Bromothiazole (8)6-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)6-Bromo-1,2,3,4-Tetrahydroquinoline (6)6-Bromo-1-Methyl-1H-Indole (3)6-Bromo-1H-Indazole (22)6-Bromo-1H-Indole (15)6-Bromo-1H-Pyrazolo[4,3-B]Pyridine (4)6-Bromo-1H-Pyrrolo[2,3-B]Pyridine (5)6-Bromo-1H-Pyrrolo[3,2-B]Pyridine (6)6-Bromo-1H-Pyrrolo[3,2-C]Pyridine (5)6-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)6-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)6-Bromo-3,4-Dihydroquinolin-2(1H)-One (4)6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (12)6-Bromo-[1,2,4]Triazolo[4,3-A]Pyridine (8)6-Bromobenzo[B]Thiophene (4)6-Bromobenzo[D]Oxazole (3)6-Bromobenzo[D]Thiazole (7)6-Bromochroman-4-One (6)6-Bromoimidazo[1,2-A]Pyrimidine (5)6-Bromoindoline-2,3-Dione (4)6-Bromoisoindolin-1-One (4)6-Bromoisoquinoline (9)6-Bromonicotinaldehyde (10)6-Bromonicotinic Acid (9)6-Bromonicotinonitrile (7)6-Bromopicolinic Acid (5)6-Bromopyrazolo[1,5-A]Pyrimidine (7)6-Bromopyridin-2-Amine (8)6-Bromopyridin-3-Amine (12)6-Bromopyridin-3-Ol (13)6-Bromoquinazoline (7)6-Bromoquinoxaline (9)7-Bromo-1,2,3,4-Tetrahydroisoquinoline (4)7-Bromo-1H-Indazole (17)7-Bromo-1H-Indole (27)7-Bromo-1H-Pyrrolo[2,3-C]Pyridine (4)7-Bromo-2,3-Dihydrobenzofuran (6)7-Bromo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (7)7-Bromo-3,4-Dihydroisoquinolin-1(2H)-One (6)7-Bromo-3,4-Dihydronaphthalen-1(2H)-One (8)7-Bromobenzo[B]Thiophene (5)7-Bromobenzo[D]Thiazole (8)7-Bromobenzofuran (6)7-Bromochromane (7)7-Bromoindoline (3)7-Bromoisoquinoline (6)8-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine (6)8-Bromochromane (6)8-Bromoimidazo[1,2-A]Pyridine (15)8-Bromoisoquinoline (17)8-Bromoquinazoline (8)9-Bromoanthracene (5)Bromocyclohexane (7)Ethyl 2-Bromo-2-Phenylacetate (6)Methyl 2-(2-Bromophenyl)Acetate (8)Methyl 2-Bromo-2-Phenylacetate (7)Methyl 2-Bromo-3-Nitrobenzoate (3)Methyl 2-Bromo-5-Fluorobenzoate (8)Methyl 2-Bromo-6-Fluorobenzoate (7)Methyl 2-Bromo-6-Methylbenzoate (8)Methyl 2-Bromobenzoate (69)Methyl 3-(Bromomethyl)Benzoate (16)Methyl 3-Bromo-4-Chlorobenzoate (6)Methyl 3-Bromo-4-Fluorobenzoate (7)Methyl 3-Bromo-4-Methoxybenzoate (10)Methyl 3-Bromo-4-Methylbenzoate (9)Methyl 3-Bromobenzoate (153)Methyl 3-Bromopicolinate (9)Methyl 4-Amino-3-Bromobenzoate (8)Methyl 5-Amino-2-Bromobenzoate (6)Methyl 6-Bromonicotinate (6)N-(2-Benzoylphenyl)-2-Bromoacetamide (3)Tert-Butyl 2-(Bromomethyl)Morpholine-4-Carboxylate (3)Tert-Butyl 3-Bromo-1H-Indole-1-Carboxylate (9)Tert-Butyl 3-Bromopiperidine-1-Carboxylate (4)
Carbamates (7462)
Carboxylic Acid Salts (658)
Alcohols (16)Aliphatic Chain Hydrocarbons (58)Alkenyls (9)Amides (4)Amines (4)Aryls (13)Carboxylic Acids (5)Esters (3)Ethers (4)Ketones (4)
Carboxylic Acids (58126)
Alcohols (162)Aldehydes (18)Aliphatic Chain Hydrocarbons (153)Aliphatic Cyclic Hydrocarbons (65)Alkenyls (126)Alkynyls (13)Amides (224)Amines (178)Aryls (839)Azetidines (17)Benzimidazoles (6)Benzofurans (9)Benzothiazoles (5)Benzoxazoles (4)Bromides (176)Carboxylic Acid Salts (5)Chlorides (172)Difluoromethyls (19)Dioxolanes (4)Esters (73)Ethers (291)Fluorinated Building Blocks (237)Furans (35)Imidazoles (42)Imidazolidines (3)Indazoles (19)Indoles (50)Indolines (16)Iodides (24)Isoquinolines (4)Isoxazoles (18)Ketones (134)Morpholines (34)Naphthyridines (3)Nitriles (45)Nitroes (44)Oxadiazoles (4)Oxazoles (16)Oxetanes (7)Phenols (21)Piperazines (26)Piperidines (89)Pyrans (2)Pyrazines (12)Pyrazoles (71)Pyridazines (10)Pyridines (172)Pyrimidines (46)Pyrroles (28)Pyrrolidines (25)Quinazolines (4)Quinolines (90)Quinoxalines (5)Spiroes (20)Sulfamides (28)Sulfides (57)Sulfones (15)Tetrahydrofurans (7)Tetrahydropyrans (12)Thiazoles (62)Thiazolidines (10)Thioesters (7)Thiophenes (66)Triazoles (10)Trifluoromethyls (71)Ureas (3)Other Aliphatic Heterocycles (12)Other Aromatic Heterocycles (64)Aceticacid (1236)Acetylbenzoic Acid (3)Acrylic (95)Aminobenzoic (6)Aminobutanoic (8)Aminoheptanoic (6)Aminohexanoic (10)Aminonicotinic Acid (4)Aminopentanoic (8)Aminophenylacetic Acid (22)Aminopropanoic (8)Aminoundecanoic Acid (4)Benzenedicarboxylic (6)Benzenedicarboxylic Acid (6)Benzylpropanoic Acid (71)Benzylsuccinic Acid (6)Boronobenzoic (4)Bromobutanoic (5)Bromododecanoate (3)Bromoisonicotinic Acid (4)Bromonicotinic (8)Bromonicotinic Acid (9)Bromophenylacetic Acid (15)Bromovalerate (4)Butanoic (115)Chlorobenzoic (35)Chloromandelic Acid (3)Cyanonicotinic (5)Cyanonicotinic Acid (3)Diacetic (19)Diaminobenzoic (7)Diaminobutanoic (3)Diaminohexanoic (4)Dibenzoic (40)Dibromobenzoic (10)Dibromobenzoic Acid (10)Dibromonicotinic Acid (7)Dicarboxylic (182)Dichlorobenzoic (21)Dichlorobenzoic Acid (21)Dichloroisonicotinic (6)Dichloroisonicotinic Acid (6)Dichlorophenylacetic Acid (4)Dienoate (14)Dienoic (10)Difluorobenzoic (54)Difluorobutanoic (3)Difluoroisonicotinic Acid (7)Difluorophenylacetic (7)Difluorophenylacetic Acid (7)Diiodobenzoic (4)Diisophthalic (17)Diisophthalic Acid (9)Diisopropylbenzoic Acid (4)Dimethoxybenzoic (33)Dimethoxyphenylacetic Acid (3)Dimethylbenzoic (31)Dimethylbutanoic (13)Dimethylpropanoic (5)Diphenylpropanoic (4)Diyldimethanol (17)Enedioic (8)Enoic (127)Ethoxybenzoic (9)Ethylbenzoic (11)Ethylbenzoic Acid (12)Ethynylbenzoic (6)Ethynylbenzoic Acid (5)Fluoroisophthalic Acid (4)Fluorophenylacetic (10)Fluorophenylacetic Acid (11)Fluorophthalic (5)Fluorophthalic Acid (3)Fluoropicolinic (12)Formylbenzoic (22)Formylbenzoic Acid (19)Guanidinopentanoic (8)Heptanoic (6)Hexacarboxylic Acid (5)Hexanoic (25)Hydrazinylbenzoic (6)Hydrazinylbenzoic Acid (5)Hydroxynicotinic (15)Isophthalic (29)Isophthalic Acid (15)Isopropoxybenzoic (8)Isopropoxybenzoic Acid (7)Isopropylbenzoic (13)Isopropylnicotinic Acid (4)Malonate (39)Mercaptobenzoic (6)Mercaptobenzoic Acid (4)Mercaptopropanoic (10)Methoxybenzoic (142)Methoxybutanoic (4)Methoxyisophthalic Acid (5)Methoxyphenylacetic (10)Methoxyphenylacetic Acid (12)Methoxypropanoic (7)Methylbenzoic (174)Methylbutanoic (30)Methylcinnamic Acid (9)Methylhexanoic (8)Methylisophthalic Acid (17)Methylnicotinic (46)Methyloctanoic (6)Methylpentanoic (102)Methylpropanoic (51)Naphthoic (64)Nitrobenzoic (159)Nitroisonicotinic Acid (5)Nitroisophthalic Acid (3)Nitronicotinic (10)Nitropicolinic (11)Octanoic (6)Oxoacetic (22)Oxobutanoic (53)Oxodecanoic (5)Oxododecanoic (9)Oxoheptanoic (5)Oxoheptanoic Acid (4)Oxohexadecanoic (13)Oxohexanoic (10)Oxooctadecanoic (7)Oxopentanoic (35)Oxopropanoic (8)Pentanedioic (17)Pentanoic (27)Phenoxybenzoic (5)Phenylacetic (34)Phenylbutanoic (41)Phenylpentanoic (11)Phenylpropanoic (26)Propanoic (990)Propenoic (6)Succinic (13)Sulfamoylbenzoic (15)Sulfobenzoic (5)Terephthalic (7)Tetraacetic (4)Tetrabenzoic (13)Tetrabenzoic Acid (14)Tetracarboxylic (13)Tribenzoic (15)Tribenzoic Acid (14)Tricarboxylic (18)Trichlorobenzoic (5)Trichlorobenzoic Acid (4)Trifluorobenzoic (12)Trifluorobenzoic Acid (11)Trifluorobutanoic (3)Trifluoromethylbenzoic (5)Trifluoromethylbenzoic Acid (4)Trifluoropentanoic (4)Trifluorophenylacetic Acid (16)Trifluoropropanoic (4)Triiodobenzoic (4)Trimethylbenzoic Acid (4)1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid (19)1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (12)1,5-Naphthyridine-3-Carboxylic Acid (6)1-((Benzyloxy)Carbonyl)Piperidine-2-Carboxylic Acid (5)1-((Benzyloxy)Carbonyl)Piperidine-3-Carboxylic Acid (3)1-((Benzyloxy)Carbonyl)Pyrrolidine-3-Carboxylic Acid (6)1-Methyl-1H-Indole-2-Carboxylic Acid (8)1-Naphthoic Acid (23)1-Phenyl-1H-Imidazole-4-Carboxylic Acid (5)1-Phenyl-1H-Pyrazole-3-Carboxylic Acid (10)1-Phenyl-1H-Pyrazole-4-Carboxylic Acid (19)1-Phenyl-1H-Pyrazole-5-Carboxylic Acid (3)1-Phenylcyclobutane-1-Carboxylic Acid (16)1-Phenylcyclohexane-1-Carboxylic Acid (6)1-Phenylcyclopropane-1-Carboxylic Acid (23)1H-Benzo[D]Imidazole-2-Carboxylic Acid (7)1H-Benzo[D]Imidazole-4-Carboxylic Acid (6)1H-Benzo[D]Imidazole-5-Carboxylic Acid (4)1H-Imidazole-2-Carboxylic Acid (7)1H-Imidazole-4-Carboxylic Acid (4)1H-Indazole-3-Carboxylic Acid (23)1H-Indazole-4-Carboxylic Acid (9)1H-Indazole-5-Carboxylic Acid (4)1H-Indazole-7-Carboxylic Acid (6)1H-Indole-3-Carboxylic Acid (28)1H-Indole-4-Carboxylic Acid (10)1H-Indole-5-Carboxylic Acid (4)1H-Indole-6-Carboxylic Acid (5)1H-Indole-7-Carboxylic Acid (7)1H-Pyrazole-4-Carboxylic Acid (9)1H-Pyrazole-5-Carboxylic Acid (10)1H-Pyrrole-2-Carboxylic Acid (30)1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid (5)1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid (4)1H-Pyrrolo[3,2-B]Pyridine-3-Carboxylic Acid (6)2,3-Difluorobenzoic Acid (35)2,3-Dihydrobenzo[B][1,4]Dioxine-2-Carboxylic Acid (3)2,3-Dihydrobenzo[B][1,4]Dioxine-6-Carboxylic Acid (3)2,4-Difluorobenzoic Acid (29)2,5-Dichlorobenzoic Acid (13)2,5-Difluorobenzoic Acid (32)2,6-Dichlorobenzoic Acid (13)2,6-Difluorobenzoic Acid (33)2-(1,3-Dioxoisoindolin-2-Yl)Propanoic Acid (3)2-(1H-Indol-1-Yl)Acetic Acid (5)2-(1H-Indol-3-Yl)Acetic Acid (28)2-(2-Bromophenyl)Acetic Acid (23)2-(2-Chlorophenyl)Acetic Acid (24)2-(2-Fluorophenyl)Acetic Acid (43)2-(2-Hydroxyphenyl)Acetic Acid (8)2-(2-Methoxyphenyl)Acetic Acid (16)2-(2-Methyl-1H-Indol-3-Yl)Acetic Acid (5)2-(2-Nitrophenyl)Acetic Acid (20)2-(2-Oxo-2H-Chromen-4-Yl)Acetic Acid (4)2-(3-Fluorophenyl)Acetic Acid (50)2-(3-Hydroxyphenyl)Acetic Acid (7)2-(3-Methoxyphenyl)Acetic Acid (23)2-(4-Chlorophenoxy)Acetic Acid (3)2-(4-Fluorophenyl)Acetic Acid (30)2-(4-Methoxyphenyl)Acetic Acid (21)2-(4-Nitrophenyl)Acetic Acid (9)2-(Benzofuran-3-Yl)Acetic Acid (3)2-(M-Tolyl)Acetic Acid (16)2-(Morpholin-2-Yl)Acetic Acid (5)2-(O-Tolyl)Acetic Acid (17)2-(P-Tolyl)Acetic Acid (9)2-(Phenylamino)Benzoic Acid (11)2-(Pyridin-3-Yl)Acetic Acid (14)2-(Pyrrolidin-1-Yl)Benzoic Acid (3)2-(Pyrrolidin-2-Yl)Acetic Acid (8)2-(Pyrrolidin-3-Yl)Acetic Acid (6)2-(Thiazol-4-Yl)Acetic Acid (9)2-(Trifluoromethoxy)Benzoic Acid (8)2-(Trifluoromethyl)Benzoic Acid (33)2-Amino-2-(2-Fluorophenyl)Acetic Acid (11)2-Amino-3-Bromobenzoic Acid (8)2-Amino-3-Chlorobenzoic Acid (7)2-Amino-6-Chlorobenzoic Acid (5)2-Benzoylbenzoic Acid (10)2-Bromo-4-Fluorobenzoic Acid (8)2-Bromo-4-Methylbenzoic Acid (5)2-Bromo-6-Fluorobenzoic Acid (11)2-Bromo-6-Methylbenzoic Acid (5)2-Chloro-3-Methoxybenzoic Acid (6)2-Chloro-3-Methylbenzoic Acid (4)2-Chloro-3-Nitrobenzoic Acid (4)2-Chloro-4-Fluorobenzoic Acid (9)2-Chloro-4-Methylbenzoic Acid (3)2-Chloro-6-Fluorobenzoic Acid (8)2-Chlorobenzoic Acid (130)2-Cyclohexylacetic Acid (13)2-Fluoro-4-Methylbenzoic Acid (7)2-Fluoro-5-Methoxybenzoic Acid (9)2-Fluorobenzoic Acid (220)2-Fluorocyclopropane-1-Carboxylic Acid (7)2-Iodobenzoic Acid (47)2-Methoxyisonicotinic Acid (13)2-Methyl-2-Phenylpropanoic Acid (20)2-Methyl-3-Nitrobenzoic Acid (7)2-Naphthoic Acid (14)2-Nitrobenzoic Acid (64)2-Oxo-2-Phenylacetic Acid (17)2-Oxo-2H-Chromene-3-Carboxylic Acid (15)2-Phenoxypropanoic Acid (13)3-(1H-Indol-3-Yl)Propanoic Acid (3)3-(2-Fluorophenyl)Acrylic Acid (17)3-(3-Chlorophenyl)Acrylic Acid (10)3-(3-Chlorophenyl)Propanoic Acid (11)3-(3-Methoxyphenyl)Propanoic Acid (9)3-(Benzyloxy)Benzoic Acid (5)3-(Chlorosulfonyl)Benzoic Acid (15)3-(Methylsulfonyl)Benzoic Acid (6)3-(Phenyldiazenyl)Benzoic Acid (7)3-(Trifluoromethoxy)Benzoic Acid (19)3-(Trifluoromethyl)Benzoic Acid (52)3-Benzamidopropanoic Acid (3)3-Bromo-2-Chlorobenzoic Acid (7)3-Bromo-2-Fluorobenzoic Acid (10)3-Bromo-2-Hydroxybenzoic Acid (4)3-Bromo-4-Chlorobenzoic Acid (6)3-Bromo-4-Fluorobenzoic Acid (10)3-Bromo-4-Hydroxybenzoic Acid (3)3-Bromo-4-Methoxybenzoic Acid (7)3-Bromo-4-Methylbenzoic Acid (9)3-Bromobenzoic Acid (159)3-Chloro-2-Fluorobenzoic Acid (9)3-Chloro-2-Methoxybenzoic Acid (4)3-Chloro-4-Fluorobenzoic Acid (8)3-Chloro-4-Methoxybenzoic Acid (5)3-Chlorobenzoic Acid (144)3-Fluoro-4-Methoxybenzoic Acid (6)3-Fluorobenzoic Acid (206)3-Fluoropicolinic Acid (6)3-Iodobenzoic Acid (54)3-Methoxy-4-Nitrobenzoic Acid (4)3-Methylpicolinic Acid (13)3-Nitrobenzoic Acid (109)3-Phenoxybenzoic Acid (6)3-Phenoxypropanoic Acid (14)4-(1H-Pyrazol-1-Yl)Benzoic Acid (3)4-(Benzyloxy)Benzoic Acid (5)4-(Phenyldiazenyl)Benzoic Acid (4)4-(Trifluoromethyl)Nicotinic Acid (3)4-Amino-3-Chlorobenzoic Acid (6)4-Benzamidobenzoic Acid (3)4-Cyclohexylbenzoic Acid (6)4-Fluoro-3-Iodobenzoic Acid (5)4-Fluorobenzoic Acid (114)4-Methylnicotinic Acid (5)4-Morpholinobenzoic Acid (5)4-Nitrobenzoic Acid (35)4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid (3)4-Oxo-4-(Phenylamino)Butanoic Acid (7)4-Oxo-4-Phenylbutanoic Acid (16)4-Oxopiperidine-2-Carboxylic Acid (3)4-Phenoxybenzoic Acid (4)4-Phenylbutanoic Acid (19)5'-(4-Carboxyphenyl)-[1,1':3',1''-Terphenyl]-4,4''-Dicarboxylic Acid (7)5-Oxotetrahydrofuran-2-Carboxylic Acid (4)5-Phenyl-1H-Pyrazole-3-Carboxylic Acid (15)5-Phenylfuran-2-Carboxylic Acid (6)5-Phenylisoxazole-3-Carboxylic Acid (15)6,6-Dimethylmorpholine-3-Carboxylic Acid (5)6-Methoxypicolinic Acid (9)6-Methylnicotinic Acid (6)6-Methylpicolinic Acid (12)6-Oxopiperidine-2-Carboxylic Acid (3)6-Phenylpicolinic Acid (3)7-Fluoro-1H-Indole-2-Carboxylic Acid (5)[1,1'-Biphenyl]-2-Carboxylic Acid (24)[1,1'-Biphenyl]-3-Carboxylic Acid (40)Azetidine-2-Carboxylic Acid (6)Benzo[B]Thiophene-2-Carboxylic Acid (32)Benzo[D]Thiazole-6-Carboxylic Acid (5)Benzofuran-2-Carboxylic Acid (21)Benzofuran-3-Carboxylic Acid (6)Benzoic Acid (3481)Benzoylglycine (15)Bicyclo[1.1.1]Pentane-1-Carboxylic Acid (6)Chromane-2-Carboxylic Acid (6)Chromane-3-Carboxylic Acid (4)Cyclobutanecarboxylic Acid (23)Cyclohex-1-Ene-1-Carboxylic Acid (4)Cyclohex-3-Ene-1-Carboxylic Acid (7)Cyclohexanecarboxylic Acid (83)Cyclopentanecarboxylic Acid (26)Cyclopropanecarboxylic Acid (11)Ethyl 5-Oxopyrrolidine-2-Carboxylate (3)Furan-2-Carboxylic Acid (30)Furan-3-Carboxylic Acid (11)Imidazo[1,2-A]Pyridine-2-Carboxylic Acid (21)Imidazo[1,2-A]Pyridine-3-Carboxylic Acid (14)Imidazo[1,2-A]Pyridine-5-Carboxylic Acid (3)Imidazo[1,2-A]Pyridine-7-Carboxylic Acid (5)Imidazo[1,2-A]Pyridine-8-Carboxylic Acid (6)Imidazo[1,2-A]Pyrimidine-3-Carboxylic Acid (5)Indoline-2-Carboxylic Acid (3)Isonicotinic Acid (23)Isoquinoline-1-Carboxylic Acid (10)Isoquinoline-3-Carboxylic Acid (7)Isoquinoline-4-Carboxylic Acid (12)Isoquinoline-5-Carboxylic Acid (5)Isoquinoline-6-Carboxylic Acid (3)Isoxazole-3-Carboxylic Acid (8)Isoxazole-5-Carboxylic Acid (7)Methyl Benzofuran-2-Carboxylate (6)Methyl Isoquinoline-3-Carboxylate (3)Morpholine-2-Carboxylic Acid (12)Morpholine-3-Carboxylic Acid (10)Nicotinic Acid (53)Oxazole-4-Carboxylic Acid (4)Picolinic Acid (22)Piperidine-2-Carboxylic Acid (26)Piperidine-3-Carboxylic Acid (14)Piperidine-4-Carboxylic Acid (12)Proline (13)Pyrazine-2-Carboxylic Acid (33)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid (7)Pyridazine-3-Carboxylic Acid (7)Pyridine-2,6-Dicarboxylic Acid (9)Pyrimidine-2-Carboxylic Acid (11)Pyrimidine-4-Carboxylic Acid (17)Pyrimidine-5-Carboxylic Acid (7)Pyrrolidine-3-Carboxylic Acid (14)Tetrahydrofuran-2-Carboxylic Acid (4)Tetrahydrofuran-3-Carboxylic Acid (4)Thiazole-2-Carboxylic Acid (9)Thiazole-4-Carboxylic Acid (5)Thiazole-5-Carboxylic Acid (10)Thiophene-3-Carboxylic Acid (8)Tryptophan (22)
Chlorides (77475)
Acyl Chlorides (88)Alcohols (150)Aldehydes (88)Aliphatic Chain Hydrocarbons (137)Aliphatic Cyclic Hydrocarbons (19)Alkenyls (55)Alkynyls (18)Amides (371)Amidines (9)Amines (308)Anhydrides (8)Aryls (1041)Azetidines (10)Benzimidazoles (15)Benzofurans (14)Benzothiazoles (6)Benzoxazoles (11)Benzyl Bromides (6)Benzyl Chlorides (49)Bromides (241)Carboxylic Acids (172)Difluoromethyls (22)Esters (294)Ethers (285)Fluorinated Building Blocks (224)Furans (9)Hydrazides (15)Hydrazines (26)Hydrazones (4)Imidazoles (15)Indazoles (9)Indoles (26)Indolines (14)Iodides (51)Isoquinolines (14)Isoxazoles (19)Ketones (139)Morpholines (24)Nitriles (97)Nitroes (81)Oxazoles (14)Oximes (7)Phenols (26)Piperazines (21)Piperidines (67)Purines (6)Pyrazines (31)Pyrazoles (26)Pyridazines (32)Pyridines (372)Pyrimidines (209)Pyrroles (13)Pyrrolidines (49)Quinazolines (20)Quinolines (110)Quinoxalines (9)Spiroes (3)Sulfamides (50)Sulfides (50)Sulfones (29)Sulfoxides (7)Tetrahydrofurans (3)Tetrahydroisoquinolines (4)Tetrahydropyrans (5)Thiadiazoles (4)Thiazoles (29)Thiophenes (49)Triazines (13)Trifluoromethyls (61)Ureas (7)Other Aliphatic Heterocycles (3)Other Aromatic Heterocycles (147)Chloroacetamide (17)Chloroacetyl (10)Chloroaniline (18)Chlorobenzaldehyde (18)Chlorobenzamide (12)Chlorobutyl (6)Chlorocarbonyl (7)Chloroethoxy (10)Chloroethyl (88)Chloromethyl (477)Chloropicolinaldehyde (8)Chloropicolinamide (5)Chloropropane (13)Chloropropoxy (2)Chloropropyl (23)Dichloride (27)Dichloroaniline (9)Dichloroanthracene (3)Dichlorobenzaldehyde (13)Dichlorobenzamide (8)Dichloroisonicotinaldehyde (4)Dichloromethyl (3)Dichloronicotinaldehyde (6)Dichloronicotinic (6)Dichloronicotinic Acid (5)Dichloropalladium (3)Tetrachloro (2)Trichloro (36)Trichloroacetimidate (5)Trichloroaniline (6)Trichlorobenzaldehyde (4)Trichloromethyl (11)(2,3-Dichlorophenyl)Boronic Acid (11)(2,6-Dichlorophenyl)Boronic Acid (6)(2-Chloroethoxy)Benzene (5)(2-Chlorophenyl)(Phenyl)Methanone (19)(2-Chlorophenyl)Hydrazine (16)(2-Chlorophenyl)Methanamine (28)(2-Chlorophenyl)Methanol (40)(2-Chloropyridin-4-Yl)Boronic Acid (6)(3,4-Dichlorophenyl)Boronic Acid (10)(3-Chloro-4-Fluorophenyl)Boronic Acid (8)(3-Chlorophenyl)(Phenyl)Methanone (19)(3-Chlorophenyl)Boronic Acid (121)(3-Chlorophenyl)Hydrazine (12)(3-Chlorophenyl)Methanamine (19)(3-Chlorophenyl)Methanol (38)(3-Chloropyridin-2-Yl)Methanamine (6)(4-Chlorophenyl)(Phenyl)Methanone (11)(5-Chloropyridin-2-Yl)Methanamine (5)(Chloromethanetriyl)Tribenzene (7)(Chloromethylene)Dibenzene (5)1,2,3,4-Tetrachlorobenzene (8)1,2,4-Trichlorobenzene (26)1,2-Dibromo-3-Chlorobenzene (3)1,2-Dichloro-3-Fluorobenzene (13)1,2-Dichloro-3-Methoxybenzene (7)1,2-Dichloro-3-Methylbenzene (8)1,2-Dichloro-4-Fluorobenzene (15)1,2-Dichloro-4-Methoxybenzene (11)1,2-Dichloro-4-Nitrobenzene (16)1,3-Dibromo-2-Chlorobenzene (8)1,3-Dichloro-2-Fluorobenzene (22)1,3-Dichloro-2-Iodobenzene (5)1,3-Dichloro-2-Methoxybenzene (9)1,3-Dichloro-2-Nitrobenzene (5)1,3-Dichloroisoquinoline (14)1,4-Dichloro-2-Fluorobenzene (11)1,4-Dichloro-2-Methoxybenzene (8)1-(2-Chlorophenyl)Ethan-1-One (40)1-(3-Chlorophenyl)-1H-Pyrazole (3)1-(3-Chlorophenyl)-N-Methylmethanamine (8)1-(3-Chlorophenyl)Ethan-1-One (38)1-(3-Chlorophenyl)Pyrrolidine (3)1-(Benzyloxy)-2-Chlorobenzene (16)1-(Benzyloxy)-3-Chlorobenzene (6)1-(Bromomethyl)-2-Chlorobenzene (28)1-(Bromomethyl)-3-Chlorobenzene (27)1-(Chloromethyl)-2-Methylbenzene (7)1-Benzyl-2-Chlorobenzene (9)1-Benzyl-3-Chlorobenzene (2)1-Benzyl-4-Chlorobenzene (6)1-Bromo-2,3-Dichlorobenzene (18)1-Bromo-2-Chloro-3-Methylbenzene (9)1-Bromo-3-Chloro-2-Fluorobenzene (9)1-Bromo-3-Chloro-2-Methylbenzene (6)1-Bromo-4-Chloro-2-Fluorobenzene (21)1-Chloro-2,3-Difluorobenzene (27)1-Chloro-2,4-Difluorobenzene (35)1-Chloro-2,4-Dimethoxybenzene (7)1-Chloro-2-(Chloromethyl)Benzene (12)1-Chloro-2-(Trifluoromethoxy)Benzene (20)1-Chloro-2-(Trifluoromethyl)Benzene (81)1-Chloro-2-Cyclopropylbenzene (7)1-Chloro-2-Ethoxybenzene (14)1-Chloro-2-Fluoro-3-Iodobenzene (5)1-Chloro-2-Fluoro-4-Nitrobenzene (9)1-Chloro-2-Iodobenzene (65)1-Chloro-2-Isocyanatobenzene (6)1-Chloro-2-Isothiocyanatobenzene (7)1-Chloro-2-Methyl-3-Nitrobenzene (6)1-Chloro-2-Nitrobenzene (138)1-Chloro-2-Phenoxybenzene (9)1-Chloro-2-Propoxybenzene (5)1-Chloro-3,5-Dimethylbenzene (8)1-Chloro-3-(Chloromethyl)Benzene (7)1-Chloro-3-(Trifluoromethoxy)Benzene (18)1-Chloro-3-(Trifluoromethyl)Benzene (101)1-Chloro-3-Fluoro-2-Methylbenzene (10)1-Chloro-3-Fluoro-2-Nitrobenzene (6)1-Chloro-3-Iodo-2-Methylbenzene (3)1-Chloro-3-Iodobenzene (78)1-Chloro-3-Methoxybenzene (125)1-Chloro-3-Nitrobenzene (160)1-Chloro-3-Phenoxybenzene (5)1-Chloro-4-(Trifluoromethoxy)Benzene (8)1-Chloro-4-Iodobenzene (49)1-Chloro-4-Methoxybenzene (98)1-Chloro-4-Phenoxybenzene (13)1-Chloroanthracene-9,10-Dione (6)1-Chloroisoquinoline (20)1-Chloronaphthalene (24)2,3,5-Trichloropyridine (13)2,3,6-Trichloropyridine (16)2,3-Dichloroaniline (18)2,3-Dichlorobenzaldehyde (7)2,3-Dichlorophenol (9)2,3-Dichloropyridine (38)2,4,5-Trichloropyrimidine (6)2,4,6-Trichloropyridine (5)2,4,6-Trichloropyrimidine (14)2,4-Dibromo-1-Chlorobenzene (8)2,4-Dichloro-1-Fluorobenzene (27)2,4-Dichloro-1-Methoxybenzene (18)2,4-Dichloro-1-Nitrobenzene (19)2,4-Dichloro-6-Methylpyridine (8)2,4-Dichloro-6-Methylpyrimidine (7)2,4-Dichlorobenzaldehyde (8)2,4-Dichlorobenzonitrile (4)2,4-Dichloropyridine (50)2,4-Dichloroquinazoline (19)2,4-Dichlorothiazole (4)2,5-Dichlorophenol (7)2,5-Dichloropyrazine (4)2,5-Dichloropyridine (32)2,6-Dichloro-3-Fluoropyridine (10)2,6-Dichloro-3-Methylpyridine (5)2,6-Dichloro-3-Nitropyridine (6)2,6-Dichloro-4-Methylpyridine (5)2,6-Dichloroaniline (26)2,6-Dichlorobenzoic Acid (13)2,6-Dichlorobenzonitrile (8)2,6-Dichloronicotinonitrile (8)2,6-Dichlorophenol (16)2,6-Dichloropyrazine (14)2,6-Dichloropyridin-3-Amine (11)2,6-Dichloropyridine (49)2-(2-Chlorophenyl)Acetic Acid (24)2-(2-Chlorophenyl)Acetonitrile (16)2-(2-Chlorophenyl)Ethan-1-Ol (8)2-(2-Chlorophenyl)Pyridine (3)2-(2-Chlorophenyl)Pyrrolidine (17)2-(3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(3-Chlorophenyl)Acetonitrile (16)2-(4-Chlorophenoxy)Acetic Acid (3)2-(Chloromethyl)-1H-Benzo[D]Imidazole (9)2-(Chloromethyl)-3-Methylpyridine (12)2-(Chloromethyl)Furan (3)2-(Chloromethyl)Pyridine (12)2-(Chloromethyl)Pyridine 1-Oxide (4)2-(Chloromethyl)Pyrimidine (5)2-(Chloromethyl)Thiazole (5)2-Amino-3-Chlorobenzoic Acid (7)2-Amino-3-Chlorobenzonitrile (3)2-Amino-6-Chlorophenol (5)2-Bromo-1,3-Dichlorobenzene (12)2-Bromo-1,4-Dichlorobenzene (12)2-Bromo-1-Chloro-4-Methylbenzene (6)2-Bromo-4-Chloro-1-Iodobenzene (6)2-Bromo-4-Chloro-1-Methoxybenzene (7)2-Bromo-4-Chloro-1-Methylbenzene (11)2-Bromo-4-Chloroaniline (15)2-Bromo-4-Chlorophenol (11)2-Bromo-6-Chloroaniline (10)2-Bromo-6-Chlorophenol (5)2-Chloro-1,1'-Biphenyl (8)2-Chloro-1,3,5-Triazine (10)2-Chloro-1,3-Difluorobenzene (27)2-Chloro-1,3-Dimethoxybenzene (3)2-Chloro-1,3-Dinitrobenzene (2)2-Chloro-1,4-Difluorobenzene (25)2-Chloro-1,4-Dimethoxybenzene (4)2-Chloro-1-Fluoro-4-Nitrobenzene (16)2-Chloro-1-Methyl-3-Nitrobenzene (4)2-Chloro-1-Phenylethan-1-One (20)2-Chloro-1H-Benzo[D]Imidazole (17)2-Chloro-3,6-Dimethylpyridine (4)2-Chloro-3-(Trifluoromethyl)Aniline (3)2-Chloro-3-(Trifluoromethyl)Pyridine (12)2-Chloro-3-Fluoropyridin-4-Amine (3)2-Chloro-3-Hydroxybenzaldehyde (4)2-Chloro-3-Methoxypyridine (12)2-Chloro-3-Methylaniline (4)2-Chloro-3-Methylbenzoic Acid (4)2-Chloro-3-Methylbenzonitrile (5)2-Chloro-3-Methylpyrazine (7)2-Chloro-3-Methylpyridine (17)2-Chloro-3-Nitropyridine (10)2-Chloro-4,6-Dimethylpyridine (7)2-Chloro-4-(Trifluoromethyl)Pyridine (9)2-Chloro-4-Ethoxypyridine (5)2-Chloro-4-Fluoro-1-Nitrobenzene (13)2-Chloro-4-Fluoroaniline (19)2-Chloro-4-Fluoropyridine (10)2-Chloro-4-Methoxypyridine (22)2-Chloro-4-Methyl-1-Nitrobenzene (6)2-Chloro-4-Methylaniline (7)2-Chloro-4-Methylbenzoic Acid (3)2-Chloro-4-Methylpyridine (31)2-Chloro-4-Methylpyrimidine (16)2-Chloro-4-Methylthiazole (5)2-Chloro-4-Phenylpyrimidine (7)2-Chloro-5-(Trifluoromethyl)Pyridine (4)2-Chloro-5-Fluoropyridin-4-Amine (3)2-Chloro-5-Fluoropyridine (16)2-Chloro-5-Methoxyaniline (8)2-Chloro-5-Methylpyridine (11)2-Chloro-5-Methylpyrimidine (5)2-Chloro-5-Methylthiazole (5)2-Chloro-5-Nitropyridine (8)2-Chloro-6-(Trifluoromethyl)Aniline (4)2-Chloro-6-(Trifluoromethyl)Pyridine (16)2-Chloro-6-Fluoroaniline (8)2-Chloro-6-Fluorophenol (5)2-Chloro-6-Fluoropyridine (14)2-Chloro-6-Iodophenol (3)2-Chloro-6-Methoxyaniline (3)2-Chloro-6-Methoxyphenol (4)2-Chloro-6-Methoxypyridine (24)2-Chloro-6-Methyl-3-Nitropyridine (4)2-Chloro-6-Methylaniline (11)2-Chloro-6-Methylnicotinonitrile (10)2-Chloro-6-Methylphenol (5)2-Chloro-6-Methylpyrazine (12)2-Chloro-6-Methylpyridine (49)2-Chloro-6-Nitroaniline (11)2-Chloro-7H-Purine (3)2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine (13)2-Chloro-9H-Purine (5)2-Chloro-N-Phenylacetamide (26)2-Chloro-N-Phenylaniline (8)2-Chloroaniline (213)2-Chlorobenzamide (16)2-Chlorobenzene-1,3-Diamine (3)2-Chlorobenzene-1,3-Diol (4)2-Chlorobenzene-1,4-Diamine (6)2-Chlorobenzenesulfonyl Chloride (24)2-Chlorobenzenethiol (7)2-Chlorobenzo[D]Oxazole (11)2-Chlorobenzo[D]Thiazole (21)2-Chlorobenzoic Acid (130)2-Chlorobenzonitrile (99)2-Chlorobenzoyl Chloride (13)2-Chlorocyclohexa-2,5-Diene-1,4-Dione (4)2-Chlorofuran (3)2-Chloroisonicotinaldehyde (19)2-Chloroisonicotinic Acid (17)2-Chloroisonicotinonitrile (7)2-Chloronaphthalene (6)2-Chloronicotinic Acid (7)2-Chloronicotinonitrile (9)2-Chlorooxazole (7)2-Chlorophenol (163)2-Chloropyrazine (24)2-Chloropyridin-3-Amine (11)2-Chloropyridin-3-Ol (9)2-Chloropyridin-4-Amine (28)2-Chloropyridine 1-Oxide (10)2-Chloroquinoxaline (39)2-Chlorothiazole (32)2-Chlorothiophene (20)3,4-Dichloroaniline (21)3,5-Dichloropyridine (16)3,6-Dichloropyridazine (20)3-(3-Chlorophenyl)Propanoic Acid (11)3-(Chloromethyl)Pyridine (22)3-Chloro-1,1'-Biphenyl (12)3-Chloro-1-Methyl-1H-Pyrazole (7)3-Chloro-1-Phenylpropan-1-One (10)3-Chloro-1H-Indazole (13)3-Chloro-2-Fluoroaniline (9)3-Chloro-2-Fluorobenzaldehyde (9)3-Chloro-2-Fluorobenzoic Acid (9)3-Chloro-2-Fluorobenzonitrile (7)3-Chloro-2-Fluoropyridine (13)3-Chloro-2-Hydroxybenzaldehyde (5)3-Chloro-2-Methoxypyridine (16)3-Chloro-2-Methylaniline (11)3-Chloro-2-Methylpyridine (4)3-Chloro-2-Nitroaniline (5)3-Chloro-4-(Trifluoromethyl)Aniline (5)3-Chloro-4-Fluoroaniline (18)3-Chloro-4-Fluorobenzoic Acid (8)3-Chloro-4-Hydroxybenzaldehyde (7)3-Chloro-4-Methylaniline (12)3-Chloro-4-Methylpyridazine (7)3-Chloro-4-Nitroaniline (5)3-Chloro-5-Fluoropyridine (10)3-Chloro-5-Methylpyridine (7)3-Chloro-5-Nitropyridine (5)3-Chloro-9H-Carbazole (3)3-Chlorobenzaldehyde (106)3-Chlorobenzene-1,2-Diamine (6)3-Chlorobenzene-1,2-Diol (6)3-Chlorobenzenesulfonyl Chloride (21)3-Chlorobenzo[B]Thiophene (6)3-Chlorobenzoic Acid (144)3-Chlorobenzonitrile (100)3-Chloroimidazo[1,2-A]Pyridine (3)3-Chloroisoquinoline (20)3-Chlorophenol (112)3-Chloropicolinic Acid (9)3-Chloropicolinonitrile (6)3-Chloropyridazine (45)3-Chloropyridin-2-Amine (17)3-Chloropyridin-2-Ol (10)3-Chlorothiophene (17)4,5-Dichloropyrimidine (7)4,6-Dichloro-2-Methylpyrimidine (7)4,6-Dichloropyridin-2-Amine (6)4,6-Dichloropyridin-3-Amine (4)4,6-Dichloropyrimidine (14)4-Chloro-1,5-Naphthyridine (6)4-Chloro-1-Phenylbutan-1-One (8)4-Chloro-1H-Indazole (18)4-Chloro-1H-Indole (21)4-Chloro-1H-Pyrazole (10)4-Chloro-1H-Pyrazolo[3,4-B]Pyridine (5)4-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine (5)4-Chloro-1H-Pyrazolo[4,3-C]Pyridine (7)4-Chloro-1H-Pyrrolo[3,2-C]Pyridine (10)4-Chloro-2,6-Dimethylpyridine (4)4-Chloro-2-Methoxypyridine (6)4-Chloro-2-Phenylpyrimidine (5)4-Chloro-3-Fluoroaniline (17)4-Chloro-3-Methylaniline (11)4-Chloro-3-Methylpyridine (7)4-Chloro-5-Methylpyrimidine (8)4-Chloro-N-Phenylaniline (6)4-Chlorobenzene-1,3-Diol (6)4-Chlorobenzenesulfonic Acid (4)4-Chlorobenzenesulfonyl Chloride (12)4-Chlorobenzo[D]Thiazole (7)4-Chloroindoline-2,3-Dione (6)4-Chloroisoquinoline (11)4-Chloronicotinic Acid (4)4-Chloropyridazine (16)4-Chloropyridin-2-Amine (6)4-Chloropyridine (31)4-Chloroquinazoline (39)5,6-Dichloro-1H-Benzo[D]Imidazole (4)5,6-Dichloropyridin-2-Amine (4)5-Bromo-4-Chloropyrimidine (4)5-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)5-Chloro-1H-Imidazole (2)5-Chloro-1H-Indazole (8)5-Chloro-1H-Indole (61)5-Chloro-1H-Indole-2-Carboxylic Acid (6)5-Chloro-1H-Pyrazole (8)5-Chloro-1H-Pyrazolo[4,3-B]Pyridine (6)5-Chloro-1H-Pyrrolo[2,3-B]Pyridine (12)5-Chloro-1H-Pyrrolo[3,2-B]Pyridine (6)5-Chloro-2,3-Dihydrobenzofuran (5)5-Chloro-2-Fluoropyridine (13)5-Chloro-2-Methoxypyridine (10)5-Chloro-2-Methylpyridine (10)5-Chlorobenzo[B]Thiophene (4)5-Chlorobenzo[D]Oxazole (5)5-Chlorobenzo[D]Thiazole (5)5-Chloroimidazo[1,2-A]Pyridine (3)5-Chloroindolin-2-One (3)5-Chloroisoquinoline (6)5-Chloropicolinic Acid (7)5-Chloropicolinonitrile (6)5-Chloropyrazolo[1,5-A]Pyrimidine (24)5-Chloropyridin-2-Amine (26)5-Chloropyridin-2-Ol (15)5-Chloropyridin-3-Amine (7)5-Chloropyrimidine (8)5-Chloroquinazoline (4)6-Chloro-1,2,3,4-Tetrahydroisoquinoline (3)6-Chloro-1,2,3,4-Tetrahydroquinoline (3)6-Chloro-1H-Benzo[D]Imidazole (25)6-Chloro-1H-Indazole (13)6-Chloro-1H-Indole (19)6-Chloro-1H-Pyrazolo[4,3-C]Pyridine (8)6-Chloro-1H-Pyrrolo[2,3-B]Pyridine (13)6-Chloro-1H-Pyrrolo[3,2-C]Pyridine (11)6-Chloro-2,3-Dihydrobenzofuran (3)6-Chloro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine (5)6-Chloro-3-Nitropyridin-2-Amine (4)6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine (3)6-Chlorobenzo[D]Oxazole (4)6-Chlorobenzo[D]Thiazole (6)6-Chlorochroman-4-One (6)6-Chlorochromane (6)6-Chloroindoline (3)6-Chloroindoline-2,3-Dione (5)6-Chloronicotinaldehyde (24)6-Chloronicotinic Acid (4)6-Chloropicolinic Acid (12)6-Chloropicolinonitrile (9)6-Chloropyridazin-3(2H)-One (5)6-Chloropyridin-2-Amine (21)6-Chloropyridin-2-Ol (9)6-Chloropyridin-3-Amine (4)6-Chloropyridine-3-Sulfonyl Chloride (5)6-Chloroquinoxaline (3)7-Chloro-1,2,3,4-Tetrahydroisoquinoline (5)7-Chloro-1H-Indazole (7)7-Chloro-1H-Indole (29)7-Chloro-1H-Pyrrolo[2,3-C]Pyridine (5)7-Chloro-2,3-Dihydrobenzofuran (3)7-Chloro-3,4-Dihydronaphthalen-1(2H)-One (6)7-Chlorobenzo[D]Thiazole (6)7-Chlorochromane (4)7-Chloroisoquinoline (6)7-Chloropyrazolo[1,5-A]Pyrimidine (8)8-Chlorochromane (5)8-Chloroimidazo[1,2-A]Pyridine (7)8-Chloroisoquinoline (7)8-Chloroquinazoline (5)Ethyl 4,6-Dichloronicotinate (4)Ethyl 5-Chloro-1H-Indole-2-Carboxylate (5)Ethyl 6-Chloropicolinate (7)Ethyl 7-Chloro-1H-Indole-2-Carboxylate (5)Methyl 2,6-Dichlorobenzoate (7)Methyl 2-Chloro-4-Fluorobenzoate (5)Methyl 2-Chloro-6-Fluorobenzoate (7)Methyl 2-Chlorobenzoate (79)Methyl 2-Chloroisonicotinate (11)Methyl 2-Chloronicotinate (6)Methyl 3-Chlorobenzoate (88)Methyl 3-Chloropicolinate (9)Methyl 6-Chloropicolinate (11)N-(2-Chlorophenyl)Acetamide (16)N-(3-Chlorophenyl)Benzenesulfonamide (6)N-(3-Chlorophenyl)Quinazolin-4-Amine (10)N-(4-Chlorophenyl)Acetamide (9)Phenyl Carbonochloridate (5)Pyridine-2-Sulfonyl Chloride (9)Pyridine-3-Sulfonyl Chloride (25)Tert-Butyl (2-Chloropyridin-4-Yl)Carbamate (4)
Diazoes (3)
Difluoromethyls (32963)
Alcohols (10)Aliphatic Chain Hydrocarbons (13)Amines (19)Aryls (43)Bromides (36)Carboxylic Acids (19)Chlorides (22)Esters (6)Ethers (64)Fluorinated Building Blocks (124)Ketones (1)Pyrazoles (11)Pyridines (56)Pyrimidines (9)(Difluoromethyl)Benzene (62)1-(Difluoromethoxy)-2-Fluorobenzene (11)1-(Difluoromethyl)-2-Fluorobenzene (13)1-Bromo-2-(Difluoromethyl)Benzene (5)2-(Difluoromethoxy)Phenol (5)2-(Difluoromethyl)Pyridine (21)3-(Difluoromethyl)Pyridine (5)4-(Difluoromethoxy)Aniline (6)5-(Difluoromethyl)-1H-Pyrazole (6)
Esters (50249)
Acyl Chlorides (22)Alcohols (236)Aldehydes (47)Aliphatic Chain Hydrocarbons (447)Aliphatic Cyclic Hydrocarbons (109)Alkenyls (243)Alkynyls (19)Amides (300)Amines (299)Anhydrides (81)Aryls (876)Azetidines (11)Benzimidazoles (12)Benzofurans (33)Benzothiazoles (5)Benzothiophenes (8)Benzoxazoles (4)Benzyl Bromides (14)Benzyl Chlorides (10)Bromides (313)Carboxylic Acid Salts (3)Carboxylic Acids (73)Chlorides (294)Difluoromethyls (6)Dioxolanes (7)Epoxides (9)Ethers (266)Fluorinated Building Blocks (189)Furans (21)Hydrazines (7)Imidazoles (34)Indazoles (8)Indoles (56)Indolines (9)Iodides (30)Isoquinolines (7)Isoxazoles (11)Ketones (316)Morpholines (31)Nitriles (100)Nitroes (72)Oxazoles (18)Oxazolidines (7)Oxazolines (6)Oxetanes (10)Oximes (5)Phenols (27)Phosphoruses (5)Piperazines (33)Piperidines (67)Pyrans (5)Pyrazines (9)Pyrazoles (29)Pyridazines (11)Pyridines (230)Pyrimidines (63)Pyrroles (21)Pyrrolidines (32)Pyrrolines (2)Quinazolines (5)Quinolines (73)Quinuclidines (3)Spiroes (18)Sulfamides (23)Sulfides (27)Sulfones (16)Tetrahydrofurans (22)Tetrahydropyrans (25)Tetrazoles (5)Thiadiazoles (4)Thiazoles (70)Thiols (9)Thiophenes (69)Triazoles (9)Trifluoromethyls (70)Other Aliphatic Heterocycles (69)Other Aromatic Heterocycles (141)Acetoxymethyl (85)Acetoxyphenyl (1)Acetyloxy (54)Acrylate (118)Acryloyloxy (3)Adipate (17)Aminobenzoate (17)Aminobenzylcarbamate (8)Aminobutanoate (14)Aminocyclobutanecarboxylic Acid (4)Aminocyclohexanecarboxylic (16)Aminocyclohexanecarboxylic Acid (10)Aminocyclopentanecarboxylic (13)Aminoheptanoate (9)Aminohexanoate (6)Aminoisonicotinate (4)Aminoisophthalate (5)Aminonicotinate (7)Aminopentanedioate (15)Aminopentanoate (7)Aminopropanoate (16)Benzoyloxy (14)Benzylcarbamate (8)Bromobenzoate (26)Bromobutanoate (10)Bromodecanoate (20)Bromoisonicotinate (8)Bromoisophthalate (3)Bromonicotinate (13)Bromopropanoate (9)Bromoundecanoate (3)Butoxycarbonyl (1434)Carbamate (1489)Chlorobenzoate (49)Chloroformate (4)Chloropicolinate (30)Chloropropanoate (5)Cyanoacrylate (5)Decanedioate (9)Decanoate (7)Diacetate (49)Diacetoxy (1)Diacrylate (15)Diaminobenzoate (7)Dibromobenzoate (4)Dicarbamate (14)Dichlorobenzoate (24)Dichloroisonicotinate (9)Diethylcarbamodithioate (1)Dimethacrylate (1)Dimethylbutanoate (14)Dimethylcarbamate (3)Dimethylnicotinate (10)Dipropanoate (6)Diyldicarbamate (5)Dodecanoate (11)Enecarboxylate (9)Enoate (115)Ethoxycarbonyl (68)Ethylbutanoate (6)Ethynylbenzoate (7)Ethynylbenzylcarbamate (3)Glutarate (3)Hexanoate (14)Iodoacrylate (6)Iodobutanoate (4)Iodopropanoate (1)Isobutyrate (18)Methacrylate (87)Methacryloyloxy (7)Methoxycarbonyl (168)Methoxyisonicotinate (11)Methoxynicotinate (24)Methoxypropanoate (5)Methylacrylate (13)Methylbutanoate (38)Methylmalonate (6)Methylnicotinate (57)Methylpentanoate (17)Methylpropanoate (45)Nitropicolinate (13)Nonanedioate (4)Oxoacetate (21)Oxobutanoate (55)Oxoheptanoate (8)Oxohexanoate (14)Oxopentanoate (30)Oxopropanoate (39)Pentanoate (13)Phenylacrylate (5)Phenylpropanoate (30)Propanoate (265)Propylpentanoate (5)Succinate (22)Sulfamoylbenzoate (6)Tetraacetate (7)Tetradecanoate (10)Tosylcarbamate (4)Tosyloxy (12)Triacetate (12)Vinylbenzoate (3)Vinylcyclopropanecarboxylic Acid (3)(2R,3S)-2-((Benzoyloxy)Methyl)Tetrahydrofuran-3-Yl Benzoate (8)(9H-Fluoren-9-Yl)Methyl (3-Phenylpropyl)Carbamate (24)1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate (5)1-Benzyl 2-Methyl Pyrrolidine-1,2-Dicarboxylate (7)1-Benzyl 3-Methyl Piperidine-1,3-Dicarboxylate (3)1-Benzyl 4-(Tert-Butyl) Piperazine-1,4-Dicarboxylate (10)1H-Indol-3-Yl Acetate (4)2,5-Dioxopyrrolidin-1-Yl Benzoate (8)2-((Tert-Butoxycarbonyl)Amino)Benzoic Acid (11)2-(Diethylamino)Ethyl Benzoate (3)2-Ethylhexyl Benzoate (12)2-Hydroxyethyl Benzoate (3)2-Phenoxyacetyl Chloride (3)4-Cyanophenyl Benzoate (11)Allyl Benzoate (5)Azetidin-3-Yl Acetate (3)Benzoic Anhydride (6)Benzyl Acetate (11)Benzyl Benzoate (12)Benzyl Benzylcarbamate (14)Benzyl Cyclohexylcarbamate (9)Benzyl Morpholine-4-Carboxylate (5)Benzyl Phenylcarbamate (15)Benzyl Piperidine-1-Carboxylate (50)Butyl Benzoate (9)Dimethyl Isophthalate (32)Dimethyl Phthalate (14)Dimethyl Pyridine-2,6-Dicarboxylate (7)Ethane-1,2-Diyl Dibenzoate (11)Ethyl 1-Phenyl-1H-Pyrazole-3-Carboxylate (3)Ethyl 1-Phenyl-1H-Pyrazole-4-Carboxylate (13)Ethyl 1-Phenylcyclopropane-1-Carboxylate (4)Ethyl 1H-1,2,4-Triazole-3-Carboxylate (3)Ethyl 1H-Imidazole-2-Carboxylate (6)Ethyl 1H-Pyrazole-4-Carboxylate (11)Ethyl 1H-Pyrrole-2-Carboxylate (24)Ethyl 1H-Pyrrole-3-Carboxylate (8)Ethyl 2-(Imidazo[1,2-A]Pyridin-3-Yl)Acetate (3)Ethyl 2-(Pyridin-2-Yl)Acetate (15)Ethyl 2-Aminobenzoate (23)Ethyl 2-Aminothiazole-4-Carboxylate (6)Ethyl 2-Aminothiazole-5-Carboxylate (5)Ethyl 2-Bromo-2-Phenylacetate (6)Ethyl 2-Fluorobenzoate (37)Ethyl 2-Hydroxybenzoate (18)Ethyl 2-Iodobenzoate (4)Ethyl 2-Methylbenzoate (26)Ethyl 2-Methylnicotinate (6)Ethyl 2-Nitrobenzoate (9)Ethyl 2-Oxo-2-(Phenylamino)Acetate (8)Ethyl 2-Oxo-2-Phenylacetate (18)Ethyl 2-Oxo-2H-Chromene-3-Carboxylate (5)Ethyl 2-Phenoxyacetate (10)Ethyl 2-Phenylacetate (60)Ethyl 2-Phenylcyclopropane-1-Carboxylate (5)Ethyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (6)Ethyl 3-Aminobenzoate (19)Ethyl 3-Fluorobenzoate (34)Ethyl 3-Hydroxybenzoate (11)Ethyl 3-Iodobenzoate (11)Ethyl 3-Nitrobenzoate (22)Ethyl 3-Oxo-3-Phenylpropanoate (41)Ethyl 3-Phenylpropanoate (17)Ethyl 4-Aminobenzoate (22)Ethyl 4-Chloropyrimidine-5-Carboxylate (5)Ethyl 5-Fluoro-1H-Indole-2-Carboxylate (5)Ethyl 6-Chloro-1H-Indole-2-Carboxylate (5)Ethyl Benzo[B]Thiophene-2-Carboxylate (9)Ethyl Cinnamate (25)Ethyl Cyclohex-1-Ene-1-Carboxylate (5)Ethyl Cyclohexanecarboxylate (33)Ethyl Cyclopropanecarboxylate (8)Ethyl Furan-2-Carboxylate (6)Ethyl Imidazo[1,2-A]Pyridine-2-Carboxylate (26)Ethyl Imidazo[1,2-A]Pyridine-3-Carboxylate (13)Ethyl Isonicotinate (12)Ethyl Isoxazole-3-Carboxylate (8)Ethyl Isoxazole-4-Carboxylate (5)Ethyl Morpholine-2-Carboxylate (4)Ethyl Nicotinate (25)Ethyl Oxazole-4-Carboxylate (8)Ethyl Oxazole-5-Carboxylate (3)Ethyl Oxirane-2-Carboxylate (4)Ethyl Picolinate (41)Ethyl Piperidine-2-Carboxylate (8)Ethyl Piperidine-3-Carboxylate (14)Ethyl Piperidine-4-Carboxylate (10)Ethyl Pyrazine-2-Carboxylate (10)Ethyl Pyridazine-3-Carboxylate (6)Ethyl Pyrimidine-4-Carboxylate (7)Ethyl Pyrimidine-5-Carboxylate (5)Ethyl Quinazoline-2-Carboxylate (4)Ethyl Thiazole-2-Carboxylate (7)Ethyl Thiazole-4-Carboxylate (7)Ethyl Thiazole-5-Carboxylate (7)Ethyl Thiophene-2-Carboxylate (19)Ethyl Thiophene-3-Carboxylate (11)Hexyl Benzoate (4)Isobutyl Benzoate (10)Isopropyl Benzoate (10)Methyl 1-Naphthoate (7)Methyl 1H-Benzo[D]Imidazole-2-Carboxylate (3)Methyl 1H-Imidazole-2-Carboxylate (4)Methyl 1H-Imidazole-5-Carboxylate (8)Methyl 1H-Indazole-4-Carboxylate (10)Methyl 1H-Indazole-5-Carboxylate (3)Methyl 1H-Indazole-6-Carboxylate (9)Methyl 1H-Indazole-7-Carboxylate (8)Methyl 1H-Indole-4-Carboxylate (9)Methyl 1H-Indole-5-Carboxylate (7)Methyl 1H-Indole-6-Carboxylate (9)Methyl 1H-Indole-7-Carboxylate (7)Methyl 1H-Pyrazole-4-Carboxylate (10)Methyl 1H-Pyrrole-2-Carboxylate (30)Methyl 1H-Pyrrole-3-Carboxylate (5)Methyl 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate (3)Methyl 1H-Pyrrolo[2,3-B]Pyridine-6-Carboxylate (3)Methyl 2,6-Dichlorobenzoate (7)Methyl 2,6-Difluorobenzoate (17)Methyl 2-(1H-Indol-3-Yl)Acetate (3)Methyl 2-(2-Bromophenyl)Acetate (8)Methyl 2-(4-Hydroxyphenyl)Acetate (10)Methyl 2-(Bromomethyl)Benzoate (33)Methyl 2-(Chlorosulfonyl)Benzoate (7)Methyl 2-(Morpholin-3-Yl)Acetate (3)Methyl 2-(Pyridin-2-Yl)Acetate (9)Methyl 2-(Trifluoromethyl)Benzoate (14)Methyl 2-Amino-2-Phenylacetate (38)Methyl 2-Aminobenzoate (95)Methyl 2-Aminothiazole-4-Carboxylate (6)Methyl 2-Bromo-2-Phenylacetate (7)Methyl 2-Bromo-3-Nitrobenzoate (3)Methyl 2-Bromo-5-Fluorobenzoate (8)Methyl 2-Bromo-6-Fluorobenzoate (7)Methyl 2-Bromo-6-Methylbenzoate (8)Methyl 2-Bromobenzoate (69)Methyl 2-Chloro-4-Fluorobenzoate (5)Methyl 2-Chloro-6-Fluorobenzoate (7)Methyl 2-Chlorobenzoate (79)Methyl 2-Cyanobenzoate (22)Methyl 2-Fluorobenzoate (132)Methyl 2-Hydroxybenzoate (74)Methyl 2-Iodobenzoate (28)Methyl 2-Methoxybenzoate (70)Methyl 2-Methyl-2H-Indazole-3-Carboxylate (3)Methyl 2-Methylbenzoate (101)Methyl 2-Naphthoate (11)Methyl 2-Nitrobenzoate (54)Methyl 2-Phenoxyacetate (12)Methyl 2-Phenoxybenzoate (4)Methyl 2-Phenylacetate (114)Methyl 3-(Benzyloxy)Benzoate (5)Methyl 3-(Bromomethyl)Benzoate (16)Methyl 3-(Trifluoromethyl)Benzoate (22)Methyl 3-Amino-3-Phenylpropanoate (27)Methyl 3-Aminobenzoate (88)Methyl 3-Bromo-4-Chlorobenzoate (6)Methyl 3-Bromo-4-Fluorobenzoate (7)Methyl 3-Bromo-4-Methoxybenzoate (10)Methyl 3-Bromo-4-Methylbenzoate (9)Methyl 3-Bromobenzoate (153)Methyl 3-Bromopyrazine-2-Carboxylate (5)Methyl 3-Chlorobenzoate (88)Methyl 3-Cyanobenzoate (29)Methyl 3-Fluorobenzoate (136)Methyl 3-Formylbenzoate (23)Methyl 3-Hydroxybenzoate (57)Methyl 3-Iodo-4-Methylbenzoate (6)Methyl 3-Iodobenzoate (47)Methyl 3-Methoxybenzoate (71)Methyl 3-Methylbenzoate (75)Methyl 3-Nitrobenzoate (109)Methyl 3-Oxo-3-Phenylpropanoate (16)Methyl 3-Phenylpropanoate (28)Methyl 4-Amino-3-Bromobenzoate (8)Methyl 4-Amino-3-Iodobenzoate (7)Methyl 4-Amino-3-Nitrobenzoate (9)Methyl 4-Aminobenzoate (71)Methyl 4-Fluorobenzoate (75)Methyl 4-Nitrobenzoate (29)Methyl 4-Oxocyclohexane-1-Carboxylate (5)Methyl 4-Oxopiperidine-2-Carboxylate (3)Methyl 4-Phenoxybenzoate (3)Methyl 5-Amino-2-Bromobenzoate (6)Methyl 5-Hydroxypicolinate (5)Methyl 5-Oxopyrrolidine-2-Carboxylate (3)Methyl 5-Phenylisoxazole-3-Carboxylate (6)Methyl 6-Bromopyrazine-2-Carboxylate (7)Methyl 6-Chloropyrazine-2-Carboxylate (5)Methyl 6-Methoxynicotinate (4)Methyl [1,1'-Biphenyl]-4-Carboxylate (7)Methyl Azetidine-2-Carboxylate (3)Methyl Benzo[B]Thiophene-2-Carboxylate (27)Methyl Benzo[D]Oxazole-2-Carboxylate (3)Methyl Benzo[D]Thiazole-6-Carboxylate (5)Methyl Bicyclo[1.1.1]Pentane-1-Carboxylate (10)Methyl Cinnamate (37)Methyl Cyclobutanecarboxylate (24)Methyl Cyclohex-3-Ene-1-Carboxylate (3)Methyl Cyclohexanecarboxylate (45)Methyl Cyclopentanecarboxylate (18)Methyl Cyclopropanecarboxylate (8)Methyl Furan-2-Carboxylate (20)Methyl Imidazo[1,2-A]Pyridine-8-Carboxylate (3)Methyl Indoline-6-Carboxylate (3)Methyl Isonicotinate (16)Methyl Isoquinoline-4-Carboxylate (6)Methyl Morpholine-2-Carboxylate (4)Methyl Morpholine-3-Carboxylate (10)Methyl Nicotinate (52)Methyl Oxazole-4-Carboxylate (9)Methyl Piperidine-2-Carboxylate (12)Methyl Piperidine-3-Carboxylate (19)Methyl Prolinate (43)Methyl Pyrazine-2-Carboxylate (19)Methyl Pyridazine-3-Carboxylate (7)Methyl Pyrimidine-2-Carboxylate (10)Methyl Pyrimidine-4-Carboxylate (11)Methyl Pyrimidine-5-Carboxylate (5)Methyl Pyrrolidine-3-Carboxylate (9)Methyl Thiazole-2-Carboxylate (6)Methyl Thiazole-4-Carboxylate (6)Methyl Thiophene-3-Carboxylate (35)Phenyl (1R,4R)-[1,1'-Bi(Cyclohexane)]-4-Carboxylate (6)Phenyl Dimethylcarbamate (5)Phenyl Ethyl(Methyl)Carbamate (5)Propyl Benzoate (11)Tert-Butyl (1-Phenylethyl)Carbamate (19)Tert-Butyl (2,3-Dihydro-1H-Inden-1-Yl)Carbamate (3)Tert-Butyl (2-Phenylcyclopropyl)Carbamate (4)Tert-Butyl (3-Oxocyclohexyl)Carbamate (3)Tert-Butyl (Morpholin-2-Ylmethyl)Carbamate (3)Tert-Butyl (Tetrahydrofuran-3-Yl)Carbamate (4)Tert-Butyl 1H-Benzo[D]Imidazole-1-Carboxylate (3)Tert-Butyl 1H-Imidazole-1-Carboxylate (6)Tert-Butyl 1H-Indazole-1-Carboxylate (29)Tert-Butyl 1H-Indole-1-Carboxylate (18)Tert-Butyl 1H-Pyrrole-1-Carboxylate (8)Tert-Butyl 1H-Pyrrole-2-Carboxylate (3)Tert-Butyl 1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate (9)Tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate (19)Tert-Butyl 3-((Methylsulfonyl)Oxy)Pyrrolidine-1-Carboxylate (5)Tert-Butyl 3-Oxopiperazine-1-Carboxylate (7)Tert-Butyl 4-Phenylpiperidine-1-Carboxylate (16)Tert-Butyl Azetidine-1-Carboxylate (64)Tert-Butyl Benzoate (66)Tert-Butyl Benzylcarbamate (52)Tert-Butyl Bicyclo[1.1.1]Pentan-1-Ylcarbamate (5)Tert-Butyl Cyclopentylcarbamate (28)Tert-Butyl Isoindoline-2-Carboxylate (13)Tert-Butyl Methyl(Phenyl)Carbamate (9)Tert-Butyl Morpholine-4-Carboxylate (23)Tert-Butyl O-Tolylcarbamate (11)Tert-Butyl Phenethylcarbamate (1)Tert-Butyl Piperazine-1-Carboxylate (30)Tert-Butyl Pyrrolidine-1-Carboxylate (21)
Ethers (82063)
Alcohols (224)Aldehydes (130)Aliphatic Chain Hydrocarbons (199)Aliphatic Cyclic Hydrocarbons (32)Alkenyls (79)Alkynyls (29)Amides (251)Amidines (4)Amines (400)Anhydrides (8)Aryls (1450)Azetidines (18)Benzimidazoles (17)Benzofurans (2)Benzothiazoles (15)Benzoxazoles (6)Benzyl Bromides (6)Benzyl Chlorides (7)Bromides (328)Carboxylic Acid Salts (4)Carboxylic Acids (291)Chlorides (285)Difluoromethyls (64)Epoxides (13)Esters (266)Fluorinated Building Blocks (233)Furans (10)Hydrazides (23)Hydrazines (40)Imidazoles (6)Indazoles (9)Indoles (54)Indolines (5)Iodides (32)Isoquinolines (8)Isoxazoles (12)Ketones (159)Morpholines (17)Nitriles (103)Nitroes (83)Oxazoles (4)Oxetanes (6)Phenols (44)Piperazines (26)Piperidines (81)Pyrans (5)Pyrazines (19)Pyrazoles (39)Pyridazines (7)Pyridines (238)Pyrimidines (113)Pyrrolidines (56)Quinazolines (17)Quinolines (81)Quinuclidines (2)Sulfamides (22)Sulfides (29)Sulfonates (4)Sulfones (12)Sulfonyl Chlorides (19)Sulfoxides (5)Tetrahydrofurans (1)Tetrahydropyrans (24)Thiadiazoles (7)Thiazoles (16)Thiophenes (5)Thiophenols (7)Triazoles (5)Trifluoromethyls (107)Other Aliphatic Heterocycles (5)Other Aromatic Heterocycles (47)Butoxy-Phenyl-Boronic Acid/Ester (68)Diethoxy (14)Diethoxyethyl (9)Diethoxymethyl (8)Dimethoxyethyl (8)Dimethoxypropane (11)Dioxane (154)Dioxepine (7)Disulfide (38)Methoxyphenylboronic-Acid (32)(1S,4Ar,7Ar)-1-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-1,4A,5,7A-Tetrahydrocyclopenta[C]Pyran (3)(2,2,2-Trifluoroethoxy)Benzene (18)(2-(Benzyloxy)Phenyl)Boronic Acid (23)(2-(Phenoxymethyl)Phenyl)Boronic Acid (3)(2-Chloro-3-Methoxyphenyl)Boronic Acid (5)(2-Chloroethoxy)Benzene (5)(2-Methoxyethoxy)Benzene (32)(3-(Benzyloxy)Phenyl)Boronic Acid (9)(3-(Phenoxymethyl)Phenyl)Boronic Acid (3)(3-Chloro-2-Methoxyphenyl)Boronic Acid (4)(3-Phenoxyphenyl)Methanol (3)(4-(Benzyloxy)Phenyl)Boronic Acid (26)(4-(Phenoxymethyl)Phenyl)Boronic Acid (6)(4-Methoxyphenyl)(Phenyl)Methanone (7)(9H-Fluoren-9-Yl)Methyl (2-(Benzyloxy)Ethyl)Carbamate (6)(9H-Fluoren-9-Yl)Methyl (4-Methoxybenzyl)Carbamate (7)(Allyloxy)Benzene (17)(Ethoxymethyl)Benzene (7)(Hexyloxy)Benzene (7)(Methoxymethyl)Benzene (30)(Prop-2-Yn-1-Yloxy)Benzene (12)(R)-2-Phenoxytetrahydro-2H-Pyran (7)(S)-7-(((S)-Tetrahydro-2H-Pyran-2-Yl)Oxy)-7,8,9,10-Tetrahydrotetracene-5,12-Dione (5)1,2-Bis(Benzyloxy)Benzene (11)1,2-Dichloro-3-Methoxybenzene (7)1,2-Dichloro-4-Methoxybenzene (11)1,2-Difluoro-3-Methoxybenzene (28)1,2-Difluoro-4-Methoxybenzene (19)1,2-Dimethoxybenzene (223)1,2-Diphenoxyethane (11)1,3-Bis(Benzyloxy)Benzene (8)1,3-Dibromo-2-Methoxybenzene (11)1,3-Dichloro-2-Methoxybenzene (9)1,3-Diiodo-2-Phenoxybenzene (1)1,3-Dimethoxybenzene (238)1,3-Diphenoxybenzene (8)1,4-Dichloro-2-Methoxybenzene (8)1,4-Dimethoxybenzene (65)1-(2-Methoxyphenyl)Ethan-1-One (34)1-(3-(Benzyloxy)Phenyl)Ethan-1-One (3)1-(3-Methoxyphenyl)Ethan-1-One (37)1-(4-(Benzyloxy)Phenyl)Ethan-1-One (4)1-(4-Methoxybenzyl)-1H-Pyrazole (5)1-(Benzyloxy)-2-Bromobenzene (12)1-(Benzyloxy)-2-Chlorobenzene (16)1-(Benzyloxy)-2-Fluorobenzene (10)1-(Benzyloxy)-2-Methoxybenzene (19)1-(Benzyloxy)-2-Methylbenzene (12)1-(Benzyloxy)-2-Nitrobenzene (3)1-(Benzyloxy)-3-Bromobenzene (12)1-(Benzyloxy)-3-Chlorobenzene (6)1-(Benzyloxy)-3-Fluorobenzene (14)1-(Benzyloxy)-3-Methylbenzene (8)1-(Benzyloxy)-3-Nitrobenzene (10)1-(Benzyloxy)-4-Bromobenzene (8)1-(Benzyloxy)-4-Iodobenzene (3)1-(Bromomethyl)-2-Methoxybenzene (14)1-(Bromomethyl)-3-Methoxybenzene (19)1-(Difluoromethoxy)-2-Fluorobenzene (11)1-Benzyl-4-Methoxybenzene (6)1-Bromo-2,3-Dimethoxybenzene (8)1-Bromo-2-Chloro-3-Methoxybenzene (6)1-Bromo-2-Ethoxybenzene (16)1-Bromo-2-Fluoro-3-Methoxybenzene (7)1-Bromo-2-Phenoxybenzene (3)1-Bromo-3-Methoxybenzene (186)1-Bromo-3-Phenoxybenzene (8)1-Bromo-4-Phenoxybenzene (8)1-Chloro-2,4-Dimethoxybenzene (7)1-Chloro-2-Ethoxybenzene (14)1-Chloro-2-Phenoxybenzene (9)1-Chloro-2-Propoxybenzene (5)1-Chloro-3-Fluoro-2-Methoxybenzene (4)1-Chloro-3-Methoxybenzene (125)1-Chloro-3-Phenoxybenzene (5)1-Chloro-4-Methoxybenzene (98)1-Chloro-4-Phenoxybenzene (13)1-Cyclopropyl-3-(4-(Quinolin-4-Yloxy)Phenyl)Urea (6)1-Ethoxy-2,3-Difluorobenzene (9)1-Ethoxy-2-Fluorobenzene (37)1-Ethoxy-3-Nitrobenzene (7)1-Fluoro-2-(Trifluoromethoxy)Benzene (20)1-Fluoro-2-Isopropoxybenzene (18)1-Fluoro-2-Phenoxybenzene (11)1-Fluoro-3-Methoxybenzene (213)1-Fluoro-3-Phenoxybenzene (8)1-Fluoro-4-(Trifluoromethoxy)Benzene (14)1-Fluoro-4-Methoxybenzene (125)1-Fluoro-4-Phenoxybenzene (8)1-Iodo-2-Methoxybenzene (50)1-Iodo-3-Methoxybenzene (48)1-Iodo-4-Methoxybenzene (34)1-Iodo-4-Phenoxybenzene (4)1-Methoxy-2-(Trifluoromethyl)Benzene (21)1-Methoxy-3-(Trifluoromethoxy)Benzene (9)1-Methoxy-3-(Trifluoromethyl)Benzene (40)1-Methoxy-3-Nitrobenzene (108)1-Methoxy-4-(Phenoxymethyl)Benzene (3)1-Methoxy-4-(Trifluoromethyl)Benzene (18)1-Methoxy-4-Nitrobenzene (90)1-Methoxynaphthalene (18)1-Methyl-3-Phenoxybenzene (9)1-Nitro-2-Phenoxybenzene (4)1-Nitro-4-Phenoxybenzene (5)1-Phenoxy-3-(Trifluoromethyl)Benzene (2)1-Phenoxy-4-(Trifluoromethyl)Benzene (2)1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea (8)2,3,5,6,8,9,11,12-Octahydrobenzo[B][1,4,7,10,13]Pentaoxacyclopentadecine (8)2,3-Dimethoxypyridine (7)2,4,6-Triphenoxy-1,3,5-Triazine (4)2,4-Dibromo-1-Methoxybenzene (6)2,4-Dichloro-1-Methoxybenzene (18)2,4-Difluoro-1-Methoxybenzene (25)2,4-Dimethoxy-1-Nitrobenzene (5)2,4-Dimethoxypyrimidine (13)2,6-Dimethoxypyridine (11)2-(2-Methoxyphenyl)Acetic Acid (16)2-(3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(3-Methoxyphenyl)Acetic Acid (23)2-(4-(Benzyloxy)Phenyl)Acetonitrile (3)2-(4-Methoxyphenyl)Acetic Acid (21)2-(Benzyloxy)Benzaldehyde (13)2-(Benzyloxy)Naphthalene (5)2-(Benzyloxy)Phenol (5)2-(Methoxymethyl)Morpholine (4)2-(Methoxymethyl)Pyrrolidine (6)2-(Phenoxymethyl)Oxirane (11)2-(Phenoxymethyl)Pyridine (5)2-(Phenoxymethyl)Tetrahydro-2H-Pyran (5)2-Bromo-1,3-Dimethoxybenzene (7)2-Bromo-1,4-Dimethoxybenzene (10)2-Bromo-1-Fluoro-4-Methoxybenzene (12)2-Bromo-1-Methoxy-3-Methylbenzene (3)2-Bromo-1-Methoxy-4-Methylbenzene (7)2-Bromo-3-Methoxypyrazine (5)2-Bromo-4-Methoxy-1-Nitrobenzene (6)2-Bromo-4-Methoxyaniline (6)2-Bromo-4-Methoxybenzaldehyde (8)2-Bromo-4-Methoxybenzoic Acid (4)2-Bromo-5-Methoxybenzaldehyde (6)2-Bromo-6-Methoxyaniline (5)2-Bromo-6-Methoxyphenol (5)2-Chloro-1,3-Dimethoxybenzene (3)2-Chloro-1,4-Dimethoxybenzene (4)2-Chloro-3-Methoxybenzaldehyde (7)2-Chloro-3-Methoxybenzoic Acid (6)2-Chloro-4-Fluoro-1-Methoxybenzene (10)2-Chloro-4-Methoxypyrimidine (14)2-Chloro-5-Methoxyaniline (8)2-Chloro-6-Methoxyaniline (3)2-Chloro-6-Methoxyphenol (4)2-Ethoxynaphthalene (4)2-Ethoxypyridine (20)2-Ethoxypyrimidine (7)2-Fluoro-1,3-Dimethoxybenzene (8)2-Fluoro-1-Methoxy-4-Nitrobenzene (8)2-Fluoro-4-Methoxyaniline (6)2-Fluoro-5-Methoxybenzoic Acid (9)2-Fluoro-5-Methoxypyridine (4)2-Fluoro-6-Methoxypyridine (6)2-Isopropoxypyridine (16)2-Methoxy-1,1'-Biphenyl (7)2-Methoxy-1,3,5-Triazine (10)2-Methoxy-4-Methylpyridine (5)2-Methoxy-5-Methylpyridine (5)2-Methoxy-6-Methylpyridine (14)2-Methoxy-6-Nitrophenol (5)2-Methoxybenzamide (9)2-Methoxybenzenesulfonyl Chloride (15)2-Methoxynaphthalene (22)2-Methoxyphenol (196)2-Methoxypyrazine (45)2-Methoxypyridine (434)2-Methoxypyrimidin-4-Amine (6)2-Methoxypyrimidine (59)2-Methoxythiophene (7)2-Methyl-N-Phenylaniline (7)2-Phenoxyacetonitrile (11)2-Phenoxyaniline (4)2-Phenoxybenzonitrile (5)2-Phenoxyethan-1-Ol (14)2-Phenoxypropanoic Acid (13)2-Phenoxypyrimidine (8)2-Phenoxytetrahydro-2H-Pyran (6)2-Phenoxythiazole (5)2-Propoxypyridine (9)3,5-Dimethoxypyridine (4)3-(3-Methoxyphenyl)Propanoic Acid (9)3-(Benzyloxy)Aniline (12)3-(Benzyloxy)Benzaldehyde (13)3-(Benzyloxy)Benzoic Acid (5)3-(Benzyloxy)Phenol (5)3-(Methoxymethyl)Morpholine (4)3-Chloro-2-Methoxybenzoic Acid (4)3-Chloro-4-Methoxyaniline (6)3-Chloro-4-Methoxybenzaldehyde (7)3-Chloro-4-Methoxybenzoic Acid (5)3-Ethoxypyridine (12)3-Fluoro-2-Methoxypyridine (14)3-Fluoro-4-Methoxybenzoic Acid (6)3-Methoxypiperidine (7)3-Methoxypyridazine (17)3-Methoxypyridine (51)3-Methoxythiophene (9)3-Phenoxyaniline (2)3-Phenoxybenzaldehyde (6)3-Phenoxybenzoic Acid (6)3-Phenoxybenzonitrile (5)3-Phenoxypropanoic Acid (14)3-Phenoxypyrrolidine (5)4-(3-Phenoxypropyl)Morpholine (7)4-(Benzyloxy)Aniline (8)4-(Benzyloxy)Benzaldehyde (23)4-(Benzyloxy)Benzoic Acid (5)4-(Benzyloxy)Phenol (2)4-(Difluoromethoxy)Aniline (6)4-(Dimethoxymethyl)Pyrimidine (5)4-(Phenylethynyl)Phenol (7)4-Chloro-2-Methoxypyrimidine (12)4-Chloro-5-Methoxypyrimidine (7)4-Chloro-6-Methoxypyrimidine (5)4-Ethoxypyridine (7)4-Ethoxypyrimidine (6)4-Methoxy-1,1'-Biphenyl (4)4-Methoxy-1H-Indazole (7)4-Methoxy-1H-Indole (11)4-Methoxy-2-Methylpyrimidine (8)4-Methoxy-N-Phenylaniline (5)4-Methoxy-N-Phenylbenzenesulfonamide (3)4-Methoxybenzenesulfonamide (5)4-Methoxypyridazine (8)4-Methoxypyridine (136)4-Methoxypyrimidin-2-Amine (6)4-Methoxypyrimidine (102)4-Phenoxyaniline (6)4-Phenoxybenzaldehyde (12)4-Phenoxybenzoic Acid (4)4-Phenoxypyridine (7)4-Phenoxypyrimidine (5)4-Phenoxyquinoline (5)4-Phenoxytetrahydro-2H-Pyran (5)5-(Benzyloxy)Pyrimidine (5)5-Fluoro-2-Methoxypyridine (15)5-Methoxy-1H-Benzo[D]Imidazole (2)5-Methoxy-1H-Indazole (4)5-Methoxy-1H-Indole (11)5-Methoxy-2-Methyl-1H-Indole (4)5-Methoxy-2-Nitroaniline (7)5-Methoxyindoline (4)5-Methoxyisobenzofuran-1(3H)-One (5)5-Methoxyisoquinoline (6)6-Methoxy-1,2,3,4-Tetrahydroisoquinoline (3)6-Methoxy-1H-Indazole (14)6-Methoxy-1H-Indole (12)6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine (3)6-Methoxy-3,4-Dihydroisoquinolin-1(2H)-One (3)6-Methoxybenzo[D]Thiazole (6)6-Methoxybenzofuran (4)6-Methoxychromane (5)6-Methoxyisoindolin-1-One (3)6-Methoxyquinoxaline (6)7-(Benzyloxy)Quinoline (6)7-Methoxy-1,2,3,4-Tetrahydroisoquinoline (6)7-Methoxy-1H-Indazole (5)7-Methoxy-1H-Indole (8)7-Methoxy-3,4-Dihydroquinolin-2(1H)-One (3)7-Methoxyisoquinoline (5)8-Methoxyisoquinoline (7)8-Methoxyquinazoline (3)Butoxybenzene (51)Ethoxybenzene (283)Ethyl 2-Phenoxyacetate (10)Isobutoxybenzene (22)Isopropoxybenzene (84)Methoxycyclohexane (7)Methyl 2-Methoxybenzoate (70)Methyl 2-Phenoxyacetate (12)Methyl 2-Phenoxybenzoate (4)Methyl 3-(Benzyloxy)Benzoate (5)Methyl 3-Methoxybenzoate (71)Methyl 4-Phenoxybenzoate (3)N,N-Dimethyl-2-Phenoxyethan-1-Amine (16)N-(2-Phenoxyphenyl)Methanesulfonamide (3)N-(4-Phenoxyphenyl)Acetamide (4)N-Phenyl-N-(4-(Quinolin-4-Yloxy)Phenyl)Cyclopropane-1,1-Dicarboxamide (5)Phenethoxybenzene (23)Propoxybenzene (63)Tert-Butoxybenzene (12)Tert-Butyl 3-Methoxypyrrolidine-1-Carboxylate (6)Tert-Butyl 4-Phenoxypiperidine-1-Carboxylate (12)Tert-Butyl 5-Methoxy-1H-Indole-1-Carboxylate (6)
Fluorinated Building Blocks (98813)
Alcohols (168)Aldehydes (79)Aliphatic Chain Hydrocarbons (167)Aliphatic Cyclic Hydrocarbons (56)Alkenyls (42)Alkynyls (6)Amides (235)Amidines (7)Amines (282)Anhydrides (8)Aryls (858)Azetidines (20)Benzimidazoles (14)Benzisoxazoles (4)Benzofurans (11)Benzothiazoles (7)Benzothiophenes (5)Benzoxazoles (5)Benzyl Bromides (2)Benzyl Chlorides (2)Bromides (304)Carboxylic Acids (237)Chlorides (224)Difluoromethyls (124)Esters (189)Ethers (233)Furans (4)Hydrazides (6)Hydrazines (12)Imidazoles (25)Indazoles (10)Indoles (37)Indolines (11)Iodides (52)Isoquinolines (7)Isoxazoles (12)Ketones (147)Morpholines (17)Naphthyridines (4)Nitriles (76)Nitroes (75)Oxazoles (5)Oxazolidines (1)Oxetanes (5)Phenols (28)Phosphoruses (5)Piperazines (22)Piperidines (95)Pyrazines (8)Pyrazoles (52)Pyridazines (4)Pyridines (296)Pyrimidines (38)Pyrroles (8)Pyrrolidines (38)Quinazolines (5)Quinolines (50)Quinoxalines (5)Spiroes (9)Sulfamides (26)Sulfides (21)Sulfonates (23)Sulfones (13)Tetrahydropyrans (8)Tetrahydroquinolines (6)Thiazoles (9)Thioesters (4)Thiophenes (18)Thiophenols (4)Trifluoromethyls (496)Other Aliphatic Heterocycles (5)Other Aromatic Heterocycles (46)Dichlorofluorobenzene (21)Difluoro (890)Difluoroaniline (37)Difluorobenzaldehyde (33)Difluorobenzamide (6)Difluorobenzenesulfonamide (5)Difluorobenzoate (59)Difluoroethyl (26)Difluoromethoxy (196)Difluoropropan (7)Fluindamine (32)Fluoroacetanilide (5)Fluoroacetophenone (8)Fluoroaniline (65)Fluoroanisole (9)Fluorobenzaldehyde (69)Fluorobenzamide (28)Fluorobenzenesulfonamide (7)Fluorobenzenethiol (6)Fluorobenzylamine (10)Fluorobromobenzene (3)Fluorocinnamic (10)Fluorocinnamic Acid (9)Fluorocyclopropanecarboxylic (9)Fluoroethoxy (4)Fluoroethyl (8)Fluoroindan (3)Fluoroisonicotinaldehyde (7)Fluoroisonicotinate (8)Fluoroisonicotinic (13)Fluoroisonicotinic Acid (13)Fluoromethyl (15)Fluoronicotinaldehyde (20)Fluoronicotinamide (3)Fluoronicotinic (19)Fluoronicotinic Acid (15)Fluorophenylisocyanate (3)Fluoropropan (15)Fluorostyryl (7)Fluorosulfonyl (12)Hexafluoro (8)Hexafluoropropan (3)Nonafluoro (2)Nonafluorohexyl (1)Octafluoro (2)Pentafluoro (4)Pentafluorobenzoate (4)Tetrafluoro (12)Tetrafluoroaniline (7)Tetrafluoroethoxy (3)Trifluoro (269)Trifluoroacetamide (8)Trifluoroacetyl (12)Trifluoroaniline (11)Trifluorobenzaldehyde (9)Trifluorobenzoate (14)Trifluorobut (36)Trifluoroethan (2)Trifluoroethanamine (23)Trifluoroethanol (6)Trifluoroethoxy (59)Trifluoroethyl (61)Trifluoromethanesulfonyl (22)Trifluoromethoxy (475)Trifluoromethylthio (5)Trifluoropropane (35)Trifluoropropanoate (5)Trifluoropropyl (9)(2,3-Difluorophenyl)Boronic Acid (33)(2,6-Difluorophenyl)Boronic Acid (28)(2-Chloro-6-Fluorophenyl)Boronic Acid (9)(2-Fluorobenzyl)Hydrazine (6)(2-Fluorophenyl)(Phenyl)Methanone (15)(2-Fluorophenyl)Boronic Acid (229)(2-Fluorophenyl)Hydrazine (22)(2-Fluorophenyl)Methanamine (49)(2-Fluorophenyl)Methanol (60)(3-Fluorophenyl)(Phenyl)Methanone (5)(3-Fluorophenyl)Boronic Acid (169)(3-Fluorophenyl)Methanol (58)(4-Fluorophenyl)(Phenyl)Methanone (8)(4-Fluorophenyl)Boronic Acid (93)(4-Fluorophenyl)Methanamine (27)(4-Fluorophenyl)Methanol (29)1,1-Difluorocyclobutane (14)1,1-Difluorocyclohexane (18)1,2,3,4,5-Pentafluorobenzene (45)1,2,3,4-Tetrafluorobenzene (68)1,2,3-Trifluorobenzene (144)1,2,4-Trifluorobenzene (197)1,2-Dibromo-3-Fluorobenzene (8)1,2-Dibromo-4-Fluorobenzene (11)1,2-Dichloro-3-Fluorobenzene (13)1,2-Dichloro-4-Fluorobenzene (15)1,2-Difluoro-3-Iodobenzene (13)1,2-Difluoro-3-Methoxybenzene (28)1,2-Difluoro-3-Methylbenzene (23)1,2-Difluoro-3-Nitrobenzene (23)1,2-Difluoro-4-Methoxybenzene (19)1,2-Difluoro-4-Nitrobenzene (43)1,2-Difluorobenzene (631)1,3-Dibromo-2,4-Difluorobenzene (5)1,3-Dibromo-2-Fluorobenzene (15)1,3-Dichloro-2-Fluorobenzene (22)1,3-Difluoro-2-Iodobenzene (12)1,3-Difluoro-2-Methylbenzene (18)1,3-Difluoro-2-Nitrobenzene (16)1,4-Dichloro-2-Fluorobenzene (11)1,4-Difluoro-2-Iodobenzene (8)1,4-Difluoro-2-Nitrobenzene (28)1,4-Difluorobenzene (343)1-(2-Fluorophenyl)Ethan-1-Amine (80)1-(2-Fluorophenyl)Ethan-1-One (58)1-(2-Fluorophenyl)Propan-1-Amine (8)1-(3-Fluorophenyl)Ethan-1-One (63)1-(4-Fluorophenyl)Ethan-1-One (36)1-(Benzyloxy)-2-Fluorobenzene (10)1-(Benzyloxy)-3-Fluorobenzene (14)1-(Bromomethyl)-2-Fluorobenzene (50)1-(Bromomethyl)-3-Fluorobenzene (47)1-(Chloromethyl)-2-Fluorobenzene (8)1-(Chloromethyl)-3-Fluorobenzene (11)1-Benzyl-4-Fluorobenzene (2)1-Bromo-2,3-Difluorobenzene (67)1-Bromo-2,4-Difluorobenzene (59)1-Bromo-2-Chloro-3-Fluorobenzene (20)1-Bromo-2-Fluoro-3-Methylbenzene (11)1-Bromo-3-Fluoro-2-Methoxybenzene (12)1-Bromo-3-Fluoro-2-Methylbenzene (17)1-Bromo-3-Fluoro-2-Nitrobenzene (10)1-Bromo-4-Fluoro-2-Methoxybenzene (11)1-Bromo-4-Fluoro-2-Methylbenzene (18)1-Chloro-2,3-Difluorobenzene (27)1-Chloro-2,4-Difluorobenzene (35)1-Chloro-3-Fluoro-2-Methoxybenzene (4)1-Chloro-3-Fluoro-2-Methylbenzene (10)1-Cyclohexyl-2-Fluorobenzene (4)1-Ethoxy-2,3-Difluorobenzene (9)1-Ethoxy-2-Fluorobenzene (37)1-Ethynyl-2-Fluorobenzene (10)1-Fluoro-2,3-Dimethylbenzene (8)1-Fluoro-2-(Methylsulfonyl)Benzene (5)1-Fluoro-2-Iodo-4-Methylbenzene (3)1-Fluoro-2-Iodobenzene (102)1-Fluoro-2-Isopropoxybenzene (18)1-Fluoro-2-Methylbenzene (255)1-Fluoro-2-Phenoxybenzene (11)1-Fluoro-3,5-Dimethylbenzene (12)1-Fluoro-3-(Methylsulfonyl)Benzene (10)1-Fluoro-3-Iodo-2-Methylbenzene (3)1-Fluoro-3-Iodobenzene (94)1-Fluoro-3-Methoxybenzene (213)1-Fluoro-3-Methylbenzene (254)1-Fluoro-3-Nitrobenzene (216)1-Fluoro-3-Phenoxybenzene (8)1-Fluoro-4-Iodobenzene (65)1-Fluoro-4-Methoxybenzene (125)1-Fluoro-4-Methylbenzene (140)1-Fluoro-4-Phenoxybenzene (8)1-Fluorobicyclo[1.1.1]Pentane (4)1-Fluoronaphthalene (23)2'-Fluoro-1,1':4',1''-Terphenyl (6)2,2',3,3',5,5',6,6'-Octafluoro-1,1'-Biphenyl (4)2,3-Difluoroaniline (34)2,3-Difluorobenzaldehyde (18)2,3-Difluorobenzoic Acid (35)2,3-Difluorobenzonitrile (29)2,3-Difluorophenol (36)2,3-Difluoropyridine (13)2,4-Dibromo-1-Fluorobenzene (18)2,4-Dichloro-1-Fluorobenzene (27)2,4-Difluoro-1-Iodobenzene (14)2,4-Difluoro-1-Methoxybenzene (25)2,4-Difluoro-1-Nitrobenzene (46)2,4-Difluoroaniline (44)2,4-Difluorobenzaldehyde (19)2,4-Difluorobenzoic Acid (29)2,4-Difluorobenzonitrile (21)2,4-Difluorophenol (21)2,5-Difluoroaniline (34)2,5-Difluorobenzoic Acid (32)2,5-Difluoropyridine (8)2,6-Difluoroaniline (23)2,6-Difluorobenzaldehyde (25)2,6-Difluorobenzoic Acid (33)2,6-Difluorobenzonitrile (28)2,6-Difluorophenol (23)2,6-Difluoropyridine (29)2-(2-Fluorophenyl)Acetic Acid (43)2-(2-Fluorophenyl)Acetonitrile (30)2-(2-Fluorophenyl)Pyrrolidine (16)2-(3-Fluorophenyl)Acetic Acid (50)2-(3-Fluorophenyl)Pyrrolidine (5)2-(4-Fluorophenyl)-1H-Indole (4)2-(4-Fluorophenyl)Acetic Acid (30)2-(Bromomethyl)-1,3-Difluorobenzene (12)2-Amino-2-(2-Fluorophenyl)Acetic Acid (11)2-Amino-3-Fluorobenzoic Acid (11)2-Bromo-1,3,4-Trifluorobenzene (16)2-Bromo-1,3-Difluorobenzene (43)2-Bromo-1,4-Difluorobenzene (64)2-Bromo-1-Chloro-3-Fluorobenzene (9)2-Bromo-1-Chloro-4-Fluorobenzene (20)2-Bromo-1-Fluoro-4-Methylbenzene (17)2-Bromo-4-Chloro-1-Fluorobenzene (16)2-Bromo-4-Fluoro-1-Methoxybenzene (12)2-Bromo-4-Fluoro-1-Methylbenzene (21)2-Bromo-4-Fluoroaniline (28)2-Bromo-4-Fluorobenzaldehyde (7)2-Bromo-4-Fluorobenzonitrile (7)2-Bromo-4-Fluorophenol (10)2-Bromo-5-Fluoroaniline (18)2-Bromo-5-Fluorobenzaldehyde (7)2-Bromo-5-Fluorobenzoic Acid (11)2-Bromo-6-Fluoroaniline (14)2-Bromo-6-Fluorophenol (9)2-Chloro-1,3-Difluorobenzene (27)2-Chloro-1,4-Difluorobenzene (25)2-Chloro-3-Fluoropyridine (20)2-Chloro-4-Fluoro-1-Methoxybenzene (10)2-Chloro-4-Fluoroaniline (19)2-Chloro-4-Fluorobenzaldehyde (10)2-Chloro-4-Fluorobenzoic Acid (9)2-Chloro-4-Fluorobenzonitrile (9)2-Chloro-4-Fluorophenol (9)2-Chloro-5-Fluoropyrimidine (6)2-Chloro-6-Fluoroaniline (8)2-Chloro-6-Fluorobenzoic Acid (8)2-Chloro-6-Fluorobenzonitrile (5)2-Chloro-6-Fluorophenol (5)2-Fluoro-1,3-Dimethoxybenzene (8)2-Fluoro-1,3-Dimethylbenzene (14)2-Fluoro-1-Iodo-4-Methylbenzene (5)2-Fluoro-3-Methylbenzaldehyde (8)2-Fluoro-3-Methylpyridine (14)2-Fluoro-4-Methoxyaniline (6)2-Fluoro-4-Methyl-1-Nitrobenzene (13)2-Fluoro-4-Methylbenzoic Acid (7)2-Fluoro-4-Methylpyridine (6)2-Fluoro-5-Methylpyridine (6)2-Fluoro-6-Methylpyridine (20)2-Fluoro-N-Methylbenzamide (12)2-Fluoro-N-Phenylaniline (4)2-Fluoro-N-Phenylbenzenesulfonamide (6)2-Fluoroaniline (262)2-Fluorobenzaldehyde (175)2-Fluorobenzamide (32)2-Fluorobenzenesulfonamide (12)2-Fluorobenzenesulfonyl Chloride (31)2-Fluorobenzoic Acid (220)2-Fluoropyridine (15)2-Fluoropyrimidine (9)3,3-Difluoropiperidine (29)3,3-Difluoropyrrolidine (29)3,4-Difluoroaniline (44)3,4-Difluorophenol (19)3,5-Difluoropyridine (12)3-Chloro-2-Fluoroaniline (9)3-Fluoro-1,1'-Biphenyl (16)3-Fluoro-2-Iodoaniline (8)3-Fluoro-2-Methylaniline (9)3-Fluoro-2-Methylpyridine (15)3-Fluoro-4-Nitroaniline (7)3-Fluoroaniline (288)3-Fluorobenzaldehyde (137)3-Fluorobenzamide (26)3-Fluorobenzenesulfonyl Chloride (22)3-Fluorobenzoic Acid (206)3-Fluorophenol (177)3-Fluoropiperidine (26)3-Fluoropyridin-2-Amine (12)3-Fluoropyridin-4-Amine (4)3-Fluorothiophene (6)4,4-Difluoropiperidine (5)4-(2-Fluorophenyl)Morpholine (8)4-(4-Fluorophenyl)Thiazole (9)4-Chloro-5-Fluoro-2-Methylpyrimidine (5)4-Fluoro-1-Methyl-2-Nitrobenzene (12)4-Fluoro-1H-Indazole (22)4-Fluoro-1H-Indole (24)4-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (6)4-Fluoro-2-Iodoaniline (7)4-Fluoro-2-Nitroaniline (14)4-Fluoroaniline (226)4-Fluorobenzaldehyde (78)4-Fluorobenzamide (19)4-Fluorobenzenesulfonyl Chloride (26)4-Fluorobenzo[D]Thiazole (6)4-Fluorobenzoic Acid (114)4-Fluorobenzonitrile (89)4-Fluoroisoquinoline (6)4-Fluorophenol (111)4-Fluoropyrimidine (8)5-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)5-Fluoro-1H-Benzo[D][1,2,3]Triazole (4)5-Fluoro-1H-Benzo[D]Imidazole (12)5-Fluoro-1H-Indole (48)5-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (9)5-Fluoro-2,3-Dihydro-1H-Indene (3)5-Fluoro-2,3-Dihydrobenzofuran (5)5-Fluoro-2-Methylpyridine (8)5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)5-Fluorochromane (6)5-Fluoroindoline (3)5-Fluoroisoindolin-1-One (3)5-Fluoropyridin-2-Amine (15)5-Fluoropyrimidine (11)6-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)6-Fluoro-1,2,3,4-Tetrahydroquinoline (3)6-Fluoro-1H-Indazole (15)6-Fluoro-1H-Indole (17)6-Fluoro-1H-Pyrrolo[2,3-B]Pyridine (3)6-Fluorobenzo[D]Thiazole (5)6-Fluorochromane (6)6-Fluoropyridin-2-Amine (8)6-Fluoropyridin-3-Amine (4)7-Fluoro-1,2,3,4-Tetrahydroisoquinoline (3)7-Fluoro-1,2,3,4-Tetrahydroquinoline (3)7-Fluoro-1H-Indazole (12)7-Fluoro-1H-Indole (24)7-Fluorobenzo[D]Thiazole (9)7-Fluoroindoline-2,3-Dione (6)7-Fluoroisoquinoline (3)8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)8-Fluorochromane (5)8-Fluoroimidazo[1,2-A]Pyridine (3)8-Fluoroisoquinoline (10)8-Fluoroquinazoline (4)Benzenesulfonyl Fluoride (50)Ethyl 2-Fluorobenzoate (37)Ethyl 3-Fluorobenzoate (34)Fluorobenzene (9773)Methyl 2,6-Difluorobenzoate (17)Methyl 2-Fluorobenzoate (132)Methyl 3-Fluorobenzoate (136)Methyl 4-Fluorobenzoate (75)Methyl 6-Fluoronicotinate (4)N-(3-Fluorophenyl)Acetamide (14)N-(4-Fluorophenyl)Benzamide (3)Pentafluoro(Phenyl)-L6-Sulfane (19)Phenyl Trifluoromethanesulfonate (27)Tert-Butyl (4-Fluorophenyl)Carbamate (9)Trifluoro(Phenyl)Borate (80)
Guanidines (763)
Aliphatic Chain Hydrocarbons (18)Amides (12)Aryls (13)Nitriles (4)Biguanide (2)
Hydrazides (3042)
Alcohols (5)Aliphatic Chain Hydrocarbons (48)Aliphatic Cyclic Hydrocarbons (5)Amides (168)Amines (8)Aryls (84)Chlorides (15)Ethers (23)Fluorinated Building Blocks (6)Hydrazines (120)Phenols (6)Pyridines (17)Thioureas (11)Ureas (7)Acetohydrazide (16)Chlorobenzhydrazide (3)Dihydrazide (5)Fluorobenzohydrazide (6)Pyrazine-2-Carbohydrazide (3)
Hydrazines (6227)
Alcohols (5)Aliphatic Chain Hydrocarbons (60)Aliphatic Cyclic Hydrocarbons (11)Amides (175)Amidines (2)Amines (26)Aryls (121)Chlorides (26)Esters (7)Ethers (40)Fluorinated Building Blocks (12)Hydrazides (120)Nitriles (5)Phenols (2)Pyridines (27)Pyrimidines (8)Pyrrolidines (3)Quinolines (4)Sulfamides (4)Tetrahydropyrans (4)Thioureas (8)Triazoles (3)Trifluoromethyls (4)Ureas (4)Dichlorophenylhydrazine (3)Hydrazinecarbothioamide (1)Hydrazinecarboxamide (1)Hydrazinylbenzoate (6)(2-Bromophenyl)Hydrazine (8)(2-Chlorophenyl)Hydrazine (16)(2-Fluorobenzyl)Hydrazine (6)(2-Fluorophenyl)Hydrazine (22)(3-Chlorophenyl)Hydrazine (12)2-Hydrazineylpyridine (32)2-Hydrazineylpyrimidine (6)3-Hydrazineylpyridine (8)4-Hydrazineylpiperidine (5)Isonicotinohydrazide (6)Phenylhydrazine (153)Picolinohydrazide (5)
Hydrazones (1737)
Amides (9)Aryls (10)Chlorides (4)1-Benzylidene-2-Phenylhydrazine (4)
Hydroxylamines (627)
Aliphatic Chain Hydrocarbons (11)Amides (12)Amines (14)Aryls (8)N-Hydroxybenzamide (8)
Iodides (14113)
Alcohols (16)Aliphatic Chain Hydrocarbons (36)Aliphatic Cyclic Hydrocarbons (10)Alkenyls (6)Amides (36)Amines (36)Aryls (86)Benzofurans (4)Bromides (54)Carboxylic Acids (24)Chlorides (51)Esters (30)Ethers (32)Fluorinated Building Blocks (52)Imidazoles (12)Indazoles (12)Indoles (10)Ketones (10)Nitriles (10)Nitroes (6)Oxetanes (6)Phenols (9)Piperidines (4)Pyrazoles (17)Pyridines (78)Pyrimidines (15)Quinolines (12)Tetrahydropyrans (4)Thiazoles (4)Thiophenes (3)Trifluoromethyls (14)Other Aromatic Heterocycles (28)Diiodo (18)Diiodobenzoate (5)Iodoaniline (60)Iodoanisole (5)Iodobenzaldehyde (38)Iodobenzamide (6)Iodoethoxy (6)Iodoethyl (5)Iodomethyl (26)Iodonicotinaldehyde (6)Iodonicotinic (14)Iodopropyl (4)(2-Iodophenyl)(Phenyl)Methanone (4)(2-Iodophenyl)Methanol (12)(3-Iodophenyl)Boronic Acid (5)(3-Iodophenyl)Methanol (13)1,2-Benziodoxol-3-(1H)-One (6)1,2-Difluoro-3-Iodobenzene (13)1,2-Diiodobenzene (10)1,3-Dibromo-2-Iodobenzene (4)1,3-Dichloro-2-Iodobenzene (5)1,3-Difluoro-2-Iodobenzene (12)1,3-Diiodo-2-Phenoxybenzene (1)1,3-Diiodobenzene (50)1,4-Dibromo-2-Iodobenzene (3)1,4-Difluoro-2-Iodobenzene (8)1-(2-Iodophenyl)Ethan-1-One (4)1-(3-Iodophenyl)Ethan-1-One (7)1-(Benzyloxy)-4-Iodobenzene (3)1-(Bromomethyl)-2-Iodobenzene (9)1-Benzyl-4-Iodo-1H-Pyrazole (5)1-Bromo-2-Iodobenzene (65)1-Bromo-3-Fluoro-2-Iodobenzene (4)1-Bromo-3-Iodobenzene (71)1-Bromo-4-Iodobenzene (67)1-Chloro-2-Fluoro-3-Iodobenzene (5)1-Chloro-2-Iodobenzene (65)1-Chloro-3-Iodo-2-Methylbenzene (3)1-Chloro-3-Iodobenzene (78)1-Chloro-4-Iodobenzene (49)1-Ethyl-2-Iodobenzene (6)1-Fluoro-2-Iodo-4-Methylbenzene (3)1-Fluoro-2-Iodobenzene (102)1-Fluoro-3-Iodo-2-Methylbenzene (3)1-Fluoro-3-Iodobenzene (94)1-Fluoro-4-Iodobenzene (65)1-Iodo-2,3-Dimethylbenzene (8)1-Iodo-2,4-Dimethylbenzene (9)1-Iodo-2-(Trifluoromethoxy)Benzene (6)1-Iodo-2-(Trifluoromethyl)Benzene (13)1-Iodo-2-Isopropylbenzene (4)1-Iodo-2-Methoxybenzene (50)1-Iodo-2-Methylbenzene (91)1-Iodo-2-Nitrobenzene (36)1-Iodo-3-(Trifluoromethoxy)Benzene (6)1-Iodo-3-(Trifluoromethyl)Benzene (30)1-Iodo-3-Methoxybenzene (48)1-Iodo-3-Methylbenzene (60)1-Iodo-3-Nitrobenzene (45)1-Iodo-4-Methoxybenzene (34)1-Iodo-4-Phenoxybenzene (4)2,4-Difluoro-1-Iodobenzene (14)2,6-Dichloro-4-Iodopyridine (4)2,6-Diiodoaniline (8)2,6-Diiodophenol (9)2-Bromo-3-Iodopyridine (6)2-Bromo-4-Chloro-1-Iodobenzene (6)2-Bromo-6-Iodoaniline (4)2-Bromo-6-Iodopyridine (5)2-Chloro-3-Iodopyridin-4-Amine (3)2-Chloro-3-Iodopyridine (13)2-Chloro-4-Iodopyridine (19)2-Chloro-5-Iodopyridine (18)2-Chloro-6-Iodophenol (3)2-Chloro-6-Iodopyridine (9)2-Fluoro-1-Iodo-4-Methylbenzene (5)2-Fluoro-3-Iodopyridine (8)2-Fluoro-6-Iodoaniline (7)2-Hydroxy-3-Iodobenzaldehyde (3)2-Iodo-1,3-Dimethylbenzene (15)2-Iodo-1,4-Dimethylbenzene (5)2-Iodo-1-Methyl-4-Nitrobenzene (3)2-Iodo-4-Methylaniline (5)2-Iodo-6-Methylpyridine (5)2-Iodo-6-Nitroaniline (3)2-Iodo-9H-Fluorene (8)2-Iodo-N,N-Dimethylaniline (3)2-Iodoaniline (87)2-Iodobenzaldehyde (17)2-Iodobenzamide (4)2-Iodobenzene-1,3-Diol (3)2-Iodobenzoic Acid (47)2-Iodobenzonitrile (26)2-Iodonaphthalene (5)2-Iodophenol (53)2-Iodopyrazine (25)2-Iodopyridine (27)2-Iodopyrimidine (8)2-Iodothiophene (14)3-Chloro-2-Iodoaniline (3)3-Chloro-4-Iodoaniline (3)3-Fluoro-2-Iodoaniline (8)3-Iodo-1-Methyl-1H-Pyrazole (6)3-Iodo-1H-Pyrrolo[2,3-B]Pyridine (11)3-Iodo-1H-Pyrrolo[3,2-B]Pyridine (6)3-Iodo-2-Methylaniline (4)3-Iodoaniline (32)3-Iodobenzaldehyde (28)3-Iodobenzoic Acid (54)3-Iodobenzonitrile (27)3-Iodoimidazo[1,2-A]Pyridine (10)3-Iodophenol (21)3-Iodopyridazine (5)3-Iodopyridin-2-Amine (12)3-Iodopyridin-2-Ol (4)3-Iodopyridin-4-Amine (6)3-Iodopyridin-4-Ol (4)3-Iodopyridine (37)3-Iodotetrahydrofuran (3)4-Bromo-2-Chloro-1-Iodobenzene (4)4-Bromo-2-Fluoro-1-Iodobenzene (8)4-Bromo-2-Iodoaniline (8)4-Chloro-2-Iodoaniline (9)4-Chloro-3-Iodoaniline (3)4-Chloro-5-Iodopyrimidine (6)4-Fluoro-2-Iodoaniline (7)4-Fluoro-3-Iodobenzoic Acid (5)4-Iodo-1,1'-Biphenyl (9)4-Iodo-1H-Pyrazole (9)4-Iodo-N,N-Diphenylaniline (3)4-Iodopyridine (17)4-Iodopyrimidine (9)5-Bromo-2-Iodopyridine (5)5-Iodo-1H-Imidazole (4)5-Iodo-1H-Pyrazole (4)5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine (4)5-Iodopyridin-2-Amine (17)5-Iodopyridin-2-Ol (8)5-Iodopyrimidine (5)6-Chloro-5-Iodopyridin-2-Amine (3)Ethyl 2-Iodobenzoate (4)Ethyl 3-Iodobenzoate (11)Methyl 2-Iodobenzoate (28)Methyl 3-Iodo-4-Methylbenzoate (6)Methyl 3-Iodobenzoate (47)Methyl 4-Amino-3-Iodobenzoate (7)N-(2-Iodophenyl)Acetamide (8)Phenyl(O-Tolyl)Iodonium (14)Tert-Butyl 3-Iodo-1H-Indole-1-Carboxylate (7)
Isocyanates and Isothiocyanates (240)
Aryls (8)Isocyanate (31)(Isothiocyanatomethyl)Benzene (6)1-Chloro-2-Isocyanatobenzene (6)1-Chloro-2-Isothiocyanatobenzene (7)Isocyanatobenzene (47)Isothiocyanatobenzene (39)
Isocyanides (68)
Aryls (2)Isocyanato (7)Isocyanide (1)Isothiocyanato (5)
Ketones (39548)
Alcohols (62)Aldehydes (19)Aliphatic Chain Hydrocarbons (182)Aliphatic Cyclic Hydrocarbons (156)Alkenyls (84)Alkynyls (8)Amides (185)Amines (87)Aryls (575)Azetidines (16)Benzofurans (10)Bromides (168)Carboxylic Acid Salts (4)Carboxylic Acids (134)Chlorides (139)Difluoromethyls (1)Dioxolanes (5)Epoxides (4)Esters (316)Ethers (159)Fluorinated Building Blocks (147)Furans (10)Imidazoles (7)Indoles (15)Indolines (11)Iodides (10)Morpholines (8)Naphthyridines (4)Nitriles (57)Nitroes (28)Phenols (33)Piperidines (66)Pyrans (7)Pyrazoles (13)Pyridazines (4)Pyridines (98)Pyrimidines (8)Pyrroles (16)Pyrrolidines (23)Quinolines (50)Spiroes (47)Sulfamides (4)Sulfides (18)Sulfones (9)Sulfonic Acids (4)Tetrahydrofurans (6)Tetrahydropyrans (7)Thiazoles (19)Thiophenes (42)Trifluoromethyls (41)Other Aliphatic Heterocycles (59)Other Aromatic Heterocycles (130)Acetylacetonate (26)Bromoethanone (4)Butanedione (6)Butanone (10)Carbonyl-Phenyl-Boronic Acid/Ester (176)Chloroethanone (1)Chromen-One (1)Dicarbonyl (2)Dichloroacetophenone (5)Dienone (2)Diethanone (3)Dione (1760)Dioxobutanoate (2)Enone (21)Ethanone (986)Heptanedionato (7)Hydroxyethanone (3)Methyl-Pyrazolone (85)Oxoacetaldehyde (4)Oxoazepane (3)Oxochroman (5)Oxotetrahydro (11)Pyrimidinone (2)Tetraone (46)Trifluoroacetophenone (9)Trifluoroethanone (14)(1E,4E)-1,5-Diphenylpenta-1,4-Dien-3-One (7)(1E,6E)-1,7-Diphenylhepta-1,6-Diene-3,5-Dione (6)(2-Aminophenyl)(Phenyl)Methanone (30)(2-Bromophenyl)(Phenyl)Methanone (3)(2-Chlorophenyl)(Phenyl)Methanone (19)(2-Fluorophenyl)(Phenyl)Methanone (15)(2-Hydroxyphenyl)(Phenyl)Methanone (23)(2-Iodophenyl)(Phenyl)Methanone (4)(3-Chlorophenyl)(Phenyl)Methanone (19)(3-Fluorophenyl)(Phenyl)Methanone (5)(3-Nitrophenyl)(Phenyl)Methanone (5)(4-Aminophenyl)(Phenyl)Methanone (4)(4-Bromophenyl)(Phenyl)Methanone (9)(4-Chlorophenyl)(Phenyl)Methanone (11)(4-Fluorophenyl)(Phenyl)Methanone (8)(4-Hydroxyphenyl)(Phenyl)Methanone (3)(4-Methoxyphenyl)(Phenyl)Methanone (7)(4-Nitrophenyl)(Phenyl)Methanone (3)(R)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-En-8-One (8)1,3-Dioxoisoindolin-2-Yl 2-Phenylacetate (5)1,3-Diphenylpropan-1-One (9)1,4-Diazepan-5-One (9)1,4-Dihydroisoquinolin-3(2H)-One (5)1-(1H-Indazol-1-Yl)Ethan-1-One (7)1-(1H-Indol-1-Yl)Ethan-1-One (9)1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One (9)1-(2-Aminophenyl)Ethan-1-One (29)1-(2-Bromophenyl)Ethan-1-One (27)1-(2-Chlorophenyl)Ethan-1-One (40)1-(2-Fluorophenyl)Ethan-1-One (58)1-(2-Hydroxyphenyl)-2-Phenylethan-1-One (6)1-(2-Hydroxyphenyl)-3-Phenylprop-2-En-1-One (11)1-(2-Hydroxyphenyl)Ethan-1-One (72)1-(2-Iodophenyl)Ethan-1-One (4)1-(2-Methoxyphenyl)Ethan-1-One (34)1-(2-Nitrophenyl)Ethan-1-One (24)1-(3-(Benzyloxy)Phenyl)Ethan-1-One (3)1-(3-Aminophenyl)Ethan-1-One (18)1-(3-Chlorophenyl)Ethan-1-One (38)1-(3-Fluorophenyl)Ethan-1-One (63)1-(3-Hydroxyphenyl)Ethan-1-One (19)1-(3-Iodophenyl)Ethan-1-One (7)1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One (4)1-(3-Methoxyphenyl)Ethan-1-One (37)1-(3-Nitrophenyl)Ethan-1-One (25)1-(3-Nitrophenyl)Propan-1-One (4)1-(4-(Benzyloxy)Phenyl)Ethan-1-One (4)1-(4-Fluorophenyl)Ethan-1-One (36)1-([1,1'-Biphenyl]-4-Yl)Ethan-1-One (5)1-(Benzofuran-2-Yl)Ethan-1-One (3)1-(Imidazo[1,2-A]Pyridin-3-Yl)Ethan-1-One (3)1-(M-Tolyl)Ethan-1-One (37)1-(Naphthalen-2-Yl)Ethan-1-One (3)1-(O-Tolyl)Ethan-1-One (26)1-(Piperidin-1-Yl)Ethan-1-One (13)1-(Pyrazin-2-Yl)Ethan-1-One (5)1-(Pyridin-2-Yl)Ethan-1-One (36)1-(Pyridin-3-Yl)Ethan-1-One (29)1-(Pyridin-4-Yl)Ethan-1-One (14)1-(Pyrimidin-2-Yl)Ethan-1-One (5)1-(Pyrimidin-4-Yl)Ethan-1-One (6)1-(Pyrrolidin-1-Yl)Ethan-1-One (9)1-(Thiazol-2-Yl)Ethan-1-One (9)1-(Thiophen-2-Yl)Ethan-1-One (17)1-Aminoanthracene-9,10-Dione (8)1-Benzylindoline-2,3-Dione (5)1-Benzylpiperidin-3-One (5)1-Chloroanthracene-9,10-Dione (6)1-Hydroxyanthracene-9,10-Dione (12)1-Methylpiperazin-2-One (6)1-Methylpyrrolidin-2-One (13)1-Phenylbutan-1-One (13)1-Phenylpentan-1-One (11)1-Phenylpiperidin-2-One (8)1-Phenylpropan-2-One (36)2,2,2-Trifluoro-1-Phenylethan-1-One (51)2,2-Dimethyl-1-Phenylpropan-1-One (8)2,2-Dimethyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2,3,4,9-Tetrahydro-1H-Carbazol-1-One (7)2,3-Dihydrofuran-3-One (9)2,3-Dihydropyridin-2-One (5)2,5-Dichlorobenzoic Acid (13)2-Amino-1-(Pyrrolidin-1-Yl)Ethan-1-One (5)2-Benzalacetophenone (36)2-Benzoylbenzoic Acid (10)2-Chloro-1-Phenylethan-1-One (20)2-Chlorocyclohexa-2,5-Diene-1,4-Dione (4)2-Chloroquinazolin-4(3H)-One (4)2-Hydroxy-1,2-Diphenylethan-1-One (3)2-Hydroxy-1-Phenylethan-1-One (8)2-Hydroxycyclohexa-2,5-Diene-1,4-Dione (3)2-Hydroxyquinolin-4(1H)-One (3)2-Methoxycyclohexa-2,5-Diene-1,4-Dione (7)2-Methyl-1-Phenylpropan-1-One (20)2-Methyl-2H-Benzo[B][1,4]Oxazin-3(4H)-One (3)2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One (6)2-Methylcyclohexa-2,5-Diene-1,4-Dione (5)2-Methylcyclohexan-1-One (3)2-Methylisoindolin-1-One (7)2-Methylisoindoline-1,3-Dione (5)2-Methylpyridazin-3(2H)-One (7)2-Oxo-2-Phenylacetaldehyde (12)2-Oxo-2-Phenylacetic Acid (17)3,3-Difluoropiperidin-4-One (3)3,3-Dimethylcyclohexan-1-One (4)3,3-Dimethylpiperidin-4-One (3)3,4-Dihydroquinoxalin-2(1H)-One (7)3-Acetyl-2H-Chromen-2-One (3)3-Aminopyrrolidin-2-One (5)3-Bromo-1H-Pyrrole-2,5-Dione (3)3-Chloro-1-Phenylpropan-1-One (10)3-Fluoropiperidin-4-One (3)3-Hydroxy-2-Phenyl-4H-Chromen-4-One (20)3-Hydroxypyrrolidin-2-One (4)3-Methylcyclohexan-1-One (9)3-Methylene-2,3-Dihydro-1H-Inden-1-One (3)3-Methylpiperazin-2-One (7)3-Methylpyrimidin-4(3H)-One (6)3-Oxo-3-Phenylpropanenitrile (21)3-Oxo-N-Phenylbutanamide (10)3-Phenyl-1-(Pyrrolidin-1-Yl)Propan-1-One (1)3-Phenyl-2-Thioxoimidazolidin-4-One (6)3-Phenylacrylaldehyde (29)3-Phenylimidazolidine-2,4-Dione (4)4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione (10)4-(1,2,2-Triphenylvinyl)Benzaldehyde (5)4-(Hydroxymethyl)Pyrrolidin-2-One (4)4-Benzylmorpholin-3-One (6)4-Bromoisoindolin-1-One (3)4-Bromopyridazin-3(2H)-One (3)4-Chloro-1-Phenylbutan-1-One (8)4-Chloropyridazin-3(2H)-One (4)4-Fluoroindoline-2,3-Dione (3)4-Hydroxy-2H-Chromen-2-One (10)4-Hydroxydihydrofuran-2(3H)-One (14)4-Hydroxypiperidin-2-One (3)4-Hydroxypyrrolidin-2-One (7)4-Methyl-2H-Chromen-2-One (27)4-Methylisobenzofuran-1(3H)-One (3)4-Oxo-4-Phenylbutanoic Acid (16)4-Phenylbutan-2-One (15)4-Phenylcyclohexan-1-One (11)4-Phenylmorpholin-3-One (6)5,6-Dihydrobenzo[D]Thiazol-7(4H)-One (5)5-(Aminomethyl)Pyrrolidin-2-One (3)5-(Hydroxymethyl)Pyrrolidin-2-One (7)5-Bromoisoindolin-1-One (8)5-Bromoisoindoline-1,3-Dione (3)5-Bromopyrimidin-4(3H)-One (3)5-Chloroisoindoline-1,3-Dione (3)5-Chloropyrimidin-4(3H)-One (4)5-Chloropyrimidine-2,4(1H,3H)-Dione (3)5-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)5-Fluorochroman-4-One (3)5-Fluoroindolin-2-One (4)5-Fluoroisoindolin-1-One (3)5-Fluoropyrimidin-4(3H)-One (3)5-Fluoropyrimidine-2,4(1H,3H)-Dione (3)5-Hydroxy-2-Phenyl-4H-Chromen-4-One (35)5-Hydroxypiperidin-2-One (3)5-Methoxy-2-Phenyl-4H-Chromen-4-One (9)5-Methyl-3,4-Dihydronaphthalen-1(2H)-One (6)5-Methylindolin-2-One (3)5-Oxopyrrolidine-2-Carboxylic Acid (4)6-Bromoisoindolin-1-One (4)6-Fluorochroman-4-One (5)6-Fluoroindoline-2,3-Dione (3)6-Fluoroisobenzofuran-1(3H)-One (3)6-Hydroxy-2,3-Dihydro-1H-Inden-1-One (3)6-Methoxy-2,3-Dihydro-1H-Inden-1-One (6)6-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (5)6-Methoxyisoindolin-1-One (3)6-Methyl-2,3-Dihydro-1H-Inden-1-One (3)7,8-Dihydroquinolin-5(6H)-One (5)7-(Diethylamino)-2H-Chromen-2-One (9)7-Bromo-3,4-Dihydronaphthalen-1(2H)-One (8)7-Bromochroman-4-One (4)7-Bromoindoline-2,3-Dione (3)7-Bromoquinazolin-4(3H)-One (4)7-Chloro-3,4-Dihydronaphthalen-1(2H)-One (6)7-Fluorochroman-4-One (5)7-Fluoroindolin-2-One (3)7-Fluoroquinazolin-4(3H)-One (4)7-Hydroxy-2H-Chromen-2-One (23)7-Methoxy-2H-Chromen-2-One (12)7-Methoxy-3,4-Dihydronaphthalen-1(2H)-One (6)7-Methoxychroman-4-One (3)7-Methylindoline-2,3-Dione (7)8-Bromochroman-4-One (4)8-Fluoro-3,4-Dihydronaphthalen-1(2H)-One (5)8-Fluoroisoquinolin-1(2H)-One (3)8-Methylchroman-4-One (4)Acetophenone (1110)Azepan-2-One (18)Benzo[Cd]Indol-2(1H)-One (5)Benzofuran-2(3H)-One (7)Chroman-2-One (5)Cyclobutanone (24)Cyclohex-2-En-1-One (27)Cyclohexane-1,3-Dione (12)Cyclopent-2-En-1-One (21)Cyclopentane-1,3-Dione (6)Dihydro-2H-Pyran-2,6(3H)-Dione (5)Dihydrofuran-2,5-Dione (12)Dihydrofuran-3(2H)-One (8)Dihydrothiophen-3(2H)-One (4)Ethene-1,1-Diyldibenzene (10)Ethyl 2-Oxo-2-Phenylacetate (18)Ethyl 3-Oxo-3-Phenylpropanoate (41)Furan-2(5H)-One (26)Isoquinolin-1-Ol (9)Methyl 3-Oxo-3-Phenylpropanoate (16)Morpholin-3-One (3)Phenyl(3-(Trifluoromethyl)Phenyl)Methanone (3)Phenyl(M-Tolyl)Methanone (3)Phenyl(P-Tolyl)Methanone (4)Phenyl(Pyridin-3-Yl)Methanone (9)Phenyl(Thiophen-2-Yl)Methanone (6)Piperidine-2,4-Dione (5)Propiophenone (55)Pyrimidine-4,6(1H,5H)-Dione (3)Tert-Butyl (2-Oxopiperidin-3-Yl)Carbamate (4)Tert-Butyl (2-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl (3-Oxocyclohexyl)Carbamate (3)Tert-Butyl (5-Oxopyrrolidin-3-Yl)Carbamate (3)Tert-Butyl (6-Oxopiperidin-3-Yl)Carbamate (3)Tert-Butyl 2-Oxopiperidine-1-Carboxylate (3)Tert-Butyl 2-Oxopyrrolidine-1-Carboxylate (15)Tert-Butyl 4-Oxopiperidine-1-Carboxylate (14)Tetrahydropyrimidin-2(1H)-One (6)
Mercaptos (10)
Mercaptopropanoate (10)
Nitrates and Nitrites (1)
Nitriles (28599)
Alcohols (44)Aldehydes (12)Aliphatic Chain Hydrocarbons (92)Aliphatic Cyclic Hydrocarbons (29)Alkenyls (62)Amides (92)Amines (142)Aryls (348)Azetidines (5)Benzyl Bromides (5)Bromides (82)Carboxylic Acids (45)Chlorides (97)Esters (100)Ethers (103)Fluorinated Building Blocks (76)Furans (7)Guanidines (4)Hydrazines (5)Indazoles (7)Indoles (29)Indolines (5)Iodides (10)Isoquinolines (4)Ketones (57)Morpholines (5)Nitroes (26)Oxazoles (6)Phenols (5)Piperazines (14)Piperidines (54)Pyrazoles (39)Pyridazines (5)Pyridines (126)Pyrimidines (15)Pyrroles (6)Pyrrolidines (11)Quinolines (19)Spiroes (2)Sulfamides (4)Sulfides (13)Sulfones (9)Sulfonyl Chlorides (5)Tetrahydropyrans (9)Thiazoles (7)Thiophenes (15)Trifluoromethyls (13)Other Aromatic Heterocycles (31)Acetonitrile (249)Acrylonitrile (8)Aminobutanenitrile (5)Aminocyclohexanecarbonitrile (6)Bromobenzonitrile (15)Bromonicotinonitrile (9)Bromophenylacetonitrile (2)Butanenitrile (2)Chlorobenzonitrile (26)Chloroisonicotinonitrile (4)Chloronicotinonitrile (40)Cyanide (428)Cyanoacetamide (4)Cyanoacetate (14)Cyanobenzaldehyde (4)Cyanobenzoate (27)Cyanobenzoic (20)Cyanoethyl (15)Cyanoisonicotinate (4)Cyanomethyl (42)Cyanonicotinate (8)Cyanophenoxy (8)Cyanophenyl (58)Cyanophenylboronic (5)Cyanopropan (4)Diacetonitrile (1)Diaminobenzonitrile (8)Dibromoisonicotinonitrile (3)Dicarbonitrile (45)Dichlorobenzonitrile (12)Dichloroisonicotinonitrile (4)Difluorobenzonitrile (41)Fluorobenzonitrile (85)Fluoroisonicotinonitrile (5)Fluoronicotinonitrile (14)Fluorophenylacetonitrile (8)Fluoropicolinonitrile (13)Formylnicotinonitrile (5)Hydrazinylbenzonitrile (6)Iodobenzonitrile (44)Iodonicotinonitrile (8)Malononitrile (41)Methoxyisonicotinonitrile (7)Methoxynicotinonitrile (17)Methylnicotinonitrile (57)Methylpropanenitrile (9)Nitropicolinonitrile (10)Oxopropanenitrile (8)Phenylacrylonitrile (20)Propanenitrile (41)Pyrazino-Nitrile (50)Tetrafluorobenzonitrile (5)Thiocyanatoaniline (3)Tricarbonitrile (5)Trifluorobenzonitrile (7)Trifluoromethylbenzonitrile (5)1-Phenyl-1H-Pyrazole-4-Carbonitrile (17)1-Phenylcyclobutane-1-Carbonitrile (7)1-Phenylcyclopropane-1-Carbonitrile (19)1H-Imidazole-4-Carbonitrile (2)1H-Indazole-3-Carbonitrile (9)1H-Indole-2-Carbonitrile (9)1H-Indole-3-Carbonitrile (17)1H-Indole-5-Carbonitrile (5)1H-Indole-6-Carbonitrile (4)1H-Indole-7-Carbonitrile (6)1H-Pyrazole-4-Carbonitrile (5)1H-Pyrrole-2-Carbonitrile (7)1H-Pyrrole-3-Carbonitrile (9)2,3-Difluorobenzonitrile (29)2,4-Dichlorobenzonitrile (4)2,4-Difluorobenzonitrile (21)2,6-Dibromobenzonitrile (4)2,6-Dichlorobenzonitrile (8)2,6-Difluorobenzonitrile (28)2-(1,3,2-Dioxaborinan-2-Yl)Benzonitrile (4)2-(2-Bromophenyl)Acetonitrile (10)2-(2-Chlorophenyl)Acetonitrile (16)2-(2-Fluorophenyl)Acetonitrile (30)2-(3-Chlorophenyl)Acetonitrile (16)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (14)2-(4-(Benzyloxy)Phenyl)Acetonitrile (3)2-(Bromomethyl)Benzonitrile (14)2-(Pyridin-2-Yl)Acetonitrile (8)2-(Pyridin-3-Yl)Acetonitrile (6)2-(Trifluoromethoxy)Benzonitrile (7)2-(Trifluoromethyl)Benzonitrile (35)2-Amino-3-Bromobenzonitrile (7)2-Amino-3-Chlorobenzonitrile (3)2-Amino-6-Chlorobenzonitrile (3)2-Aminonicotinonitrile (6)2-Bromo-6-Fluorobenzonitrile (7)2-Chloro-3-Methylbenzonitrile (5)2-Chloro-4-Fluorobenzonitrile (9)2-Chloro-6-Fluorobenzonitrile (5)2-Chloro-N-Methylaniline (4)2-Chlorobenzonitrile (99)2-Hydroxybenzonitrile (45)2-Iodobenzonitrile (26)2-Naphthonitrile (15)2-Nitrobenzonitrile (37)2-Oxo-2H-Chromene-3-Carbonitrile (4)2-Phenoxyacetonitrile (11)2-Phenoxybenzonitrile (5)2-Phenylacetonitrile (172)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (25)3-(Trifluoromethoxy)Benzonitrile (11)3-(Trifluoromethyl)Benzonitrile (47)3-Bromo-2-Fluorobenzonitrile (10)3-Bromo-2-Hydroxybenzonitrile (3)3-Bromobenzonitrile (109)3-Chloro-2-Fluorobenzonitrile (7)3-Chlorobenzonitrile (100)3-Chloropyrazine-2-Carbonitrile (6)3-Fluoropicolinonitrile (5)3-Hydroxybenzonitrile (40)3-Iodobenzonitrile (27)3-Nitrobenzonitrile (59)3-Oxo-3-Phenylpropanenitrile (21)3-Phenoxybenzonitrile (5)4-Amino-2-Chlorobenzonitrile (8)4-Chloropyrimidine-5-Carbonitrile (6)4-Cyanophenyl Benzoate (11)4-Cyclohexylbenzonitrile (10)4-Fluorobenzonitrile (89)4-Nitrobenzonitrile (25)5-Fluoropicolinonitrile (5)6-Methylnicotinonitrile (7)6-Methylpicolinonitrile (10)[1,1'-Biphenyl]-2-Carbonitrile (12)[1,1'-Biphenyl]-4-Carbonitrile (27)Benzo[B]Thiophene-2-Carbonitrile (3)Benzo[D]Thiazole-2-Carbonitrile (11)Benzonitrile (1374)Furan-2-Carbonitrile (8)Imidazo[1,2-A]Pyridine-6-Carbonitrile (3)Isonicotinonitrile (16)Isoquinoline-1-Carbonitrile (7)Methyl 2-Cyanobenzoate (22)Methyl 3-Cyanobenzoate (29)Morpholine-2-Carbonitrile (4)Nicotinonitrile (82)Pyrazine-2-Carbonitrile (15)Pyrimidine-2-Carbonitrile (14)Pyrimidine-4-Carbonitrile (9)Pyrimidine-5-Carbonitrile (6)Pyrrolidine-2-Carbonitrile (9)Pyrrolidine-3-Carbonitrile (6)Thiazole-5-Carbonitrile (7)Thiophene-2-Carbonitrile (23)Thiophene-3-Carbonitrile (13)
Nitroes (23886)
Alcohols (42)Aldehydes (22)Aliphatic Chain Hydrocarbons (7)Alkenyls (21)Amines (112)Anhydrides (5)Aryls (348)Benzofurans (5)Benzothiazoles (5)Benzoxazoles (5)Bromides (62)Carboxylic Acids (44)Chlorides (81)Epoxides (5)Esters (72)Ethers (83)Fluorinated Building Blocks (75)Furans (8)Imidazoles (13)Indazoles (7)Indoles (10)Indolines (9)Iodides (6)Ketones (28)Morpholines (12)Nitriles (26)Oxazoles (4)Phenols (12)Piperazines (6)Piperidines (13)Pyrazoles (28)Pyridines (61)Pyrimidines (13)Pyrroles (8)Pyrrolidines (12)Quinazolines (4)Quinolines (19)Quinoxalines (7)Sulfamides (7)Sulfides (12)Sulfonates (6)Thiazoles (8)Thiophenes (7)Trifluoromethyls (5)Other Aromatic Heterocycles (22)Difluoronitrobenzene (9)Dinitro (7)Dinitroaniline (5)Nitroacetophenone (7)Nitroaniline (207)Nitrobenzaldehyde (100)Nitrobenzamide (35)Nitrobenzenesulfonamide (26)Nitrobenzonitrile (105)Nitrobenzotrifluoride (16)Nitroisophthalate (4)(2-Nitrophenyl)Boronic Acid (13)(2-Nitrophenyl)Methanol (29)(2-Nitrovinyl)Benzene (28)(3-Nitrophenyl)(Phenyl)Methanone (5)(3-Nitrophenyl)Boronic Acid (32)(3-Nitrophenyl)Methanol (31)(4-Nitrophenyl)(Phenyl)Methanone (3)(4-Nitrophenyl)Methanol (17)1,2-Dichloro-4-Nitrobenzene (16)1,2-Difluoro-3-Nitrobenzene (23)1,2-Difluoro-4-Nitrobenzene (43)1,2-Dimethyl-3-Nitrobenzene (6)1,2-Dinitrobenzene (6)1,3-Dibromo-2-Nitrobenzene (4)1,3-Dichloro-2-Nitrobenzene (5)1,3-Difluoro-2-Nitrobenzene (16)1,3-Dimethyl-2-Nitrobenzene (9)1,3-Dinitrobenzene (31)1,4-Difluoro-2-Nitrobenzene (28)1,4-Dimethyl-2-Nitrobenzene (10)1-(2-Nitrophenyl)Ethan-1-One (24)1-(3-Methoxy-2-Nitrophenyl)Ethan-1-One (4)1-(3-Nitrophenyl)Ethan-1-One (25)1-(3-Nitrophenyl)Propan-1-One (4)1-(Benzyloxy)-2-Nitrobenzene (3)1-(Benzyloxy)-3-Nitrobenzene (10)1-(Bromomethyl)-2-Nitrobenzene (23)1-(Methylsulfonyl)-3-Nitrobenzene (7)1-(Tert-Butyl)-2-Nitrobenzene (4)1-(Tert-Butyl)-3-Nitrobenzene (7)1-Bromo-2-Chloro-4-Nitrobenzene (5)1-Bromo-2-Fluoro-3-Nitrobenzene (11)1-Bromo-2-Fluoro-4-Nitrobenzene (13)1-Bromo-3-Methyl-2-Nitrobenzene (3)1-Bromo-3-Nitrobenzene (235)1-Chloro-2-Fluoro-4-Nitrobenzene (9)1-Chloro-2-Methyl-3-Nitrobenzene (6)1-Chloro-2-Nitrobenzene (138)1-Chloro-3-Fluoro-2-Nitrobenzene (6)1-Chloro-3-Nitrobenzene (160)1-Ethoxy-3-Nitrobenzene (7)1-Fluoro-3-Nitrobenzene (216)1-Iodo-2-Nitrobenzene (36)1-Iodo-3-Nitrobenzene (45)1-Methoxy-3-Nitrobenzene (108)1-Methoxy-4-Nitrobenzene (90)1-Methyl-2-Nitrobenzene (175)1-Methyl-3-Nitrobenzene (147)1-Methyl-4-Nitrobenzene (82)1-Nitro-2-(Trifluoromethoxy)Benzene (8)1-Nitro-2-(Trifluoromethyl)Benzene (32)1-Nitro-2-Phenoxybenzene (4)1-Nitro-3-(Trifluoromethoxy)Benzene (9)1-Nitro-3-(Trifluoromethyl)Benzene (82)1-Nitro-4-Phenoxybenzene (5)1-Nitronaphthalene (3)2,4-Dichloro-1-Nitrobenzene (19)2,4-Difluoro-1-Nitrobenzene (46)2,4-Dimethoxy-1-Nitrobenzene (5)2,4-Dimethyl-1-Nitrobenzene (15)2-((2-Nitrophenyl)Amino)Ethan-1-Ol (5)2-(2-Nitrophenyl)Acetic Acid (20)2-(4-Nitrophenyl)Acetic Acid (9)2-Bromo-1-Chloro-4-Nitrobenzene (9)2-Bromo-1-Fluoro-3-Nitrobenzene (9)2-Bromo-1-Fluoro-4-Nitrobenzene (23)2-Bromo-1-Methyl-4-Nitrobenzene (12)2-Bromo-3-Nitrobenzoic Acid (4)2-Bromo-4-Chloro-1-Nitrobenzene (5)2-Bromo-4-Fluoro-1-Nitrobenzene (23)2-Bromo-4-Nitroaniline (12)2-Bromo-6-Nitroaniline (14)2-Bromo-6-Nitrophenol (9)2-Chloro-1,3-Dinitrobenzene (2)2-Chloro-1-Fluoro-4-Nitrobenzene (16)2-Chloro-1-Methyl-3-Nitrobenzene (4)2-Chloro-3-Nitrobenzoic Acid (4)2-Chloro-4-Fluoro-1-Nitrobenzene (13)2-Chloro-4-Methyl-1-Nitrobenzene (6)2-Chloro-4-Nitrophenol (5)2-Chloro-5-Nitropyrimidine (5)2-Chloro-6-Nitroaniline (11)2-Chloro-6-Nitrophenol (7)2-Fluoro-1-Methoxy-4-Nitrobenzene (8)2-Fluoro-4-Methyl-1-Nitrobenzene (13)2-Iodo-1-Methyl-4-Nitrobenzene (3)2-Iodo-6-Nitroaniline (3)2-Methoxy-5-Nitropyridine (8)2-Methoxy-6-Nitrophenol (5)2-Methyl-3-Nitrobenzoic Acid (7)2-Methyl-3-Nitropyridine (9)2-Methyl-6-Nitroaniline (10)2-Nitro-1H-Pyrrole (5)2-Nitro-N-Phenylaniline (3)2-Nitrobenzaldehyde (53)2-Nitrobenzoic Acid (64)2-Nitrobenzonitrile (37)2-Nitrofuran (9)2-Nitronaphthalene (4)2-Nitropyridine (40)2-Nitrothiophene (20)3-Chloro-2-Nitroaniline (5)3-Chloro-4-Nitroaniline (5)3-Fluoro-4-Nitroaniline (7)3-Methoxy-2-Nitrobenzaldehyde (3)3-Methoxy-4-Nitrobenzoic Acid (4)3-Methyl-5-Nitropyridine (4)3-Nitroaniline (98)3-Nitrobenzaldehyde (49)3-Nitrobenzamide (17)3-Nitrobenzene-1,2-Diol (6)3-Nitrobenzenesulfonamide (8)3-Nitrobenzoic Acid (109)3-Nitrobenzonitrile (59)3-Nitrophenol (72)3-Nitropyridin-2-Ol (11)3-Nitropyridin-4-Amine (5)3-Nitropyridine (54)3-Nitrothiophene (6)4,4,5,5-Tetramethyl-2-(2-Nitrophenyl)-1,3,2-Dioxaborolane (5)4-Fluoro-1-Methyl-2-Nitrobenzene (12)4-Fluoro-2-Nitroaniline (14)4-Hydroxy-3-Nitrobenzaldehyde (5)4-Methyl-3-Nitroaniline (8)4-Methyl-3-Nitropyridine (8)4-Nitro-1H-Indazole (10)4-Nitro-1H-Indole (6)4-Nitro-1H-Pyrazole (8)4-Nitroaniline (64)4-Nitrobenzaldehyde (18)4-Nitrobenzene-1,3-Diol (5)4-Nitrobenzoic Acid (35)4-Nitrobenzonitrile (25)4-Nitrophenol (67)4-Nitropyridine (11)5-(4-Nitrophenyl)Oxazole (3)5-Methoxy-2-Nitroaniline (7)5-Methyl-2-Nitroaniline (6)5-Nitro-1H-Indazole (5)5-Nitro-1H-Indole (6)5-Nitro-1H-Pyrazole (9)5-Nitro-1H-Pyrazolo[3,4-B]Pyridine (3)5-Nitro-2,3-Dihydrobenzofuran (3)5-Nitrobenzo[D][1,3]Dioxole (4)5-Nitrobenzo[D]Thiazole (3)5-Nitroisoquinoline (7)5-Nitronicotinic Acid (5)5-Nitropyridin-2-Amine (6)6-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)6-Nitro-1H-Indazole (9)6-Nitro-1H-Indole (8)6-Nitrobenzo[D]Thiazole (3)7-Nitro-1,2,3,4-Tetrahydroisoquinoline (3)7-Nitro-1H-Indazole (11)7-Nitro-1H-Indole (11)Ethyl 2-Nitrobenzoate (9)Ethyl 3-Nitrobenzoate (22)Ethyl Cinnamate (25)Methyl 2-Nitrobenzoate (54)Methyl 3-Nitrobenzoate (109)Methyl 4-Amino-3-Nitrobenzoate (9)Methyl 4-Nitrobenzoate (29)N-(2-Nitrophenyl)Acetamide (11)N-Methyl-2-Nitroaniline (20)N-Methyl-4-Nitroaniline (5)Nitrobenzene (2273)
Oximes (851)
Amidines (24)Amines (5)Aryls (24)Chlorides (7)Esters (5)Piperidines (5)Pyridines (11)
Phenols (6869)
Aminophenol (9)Bromophenol (13)Chlorophenol (27)Dibromophenol (9)Dichlorophenol (17)Difluorophenol (36)Dihydroxybenzaldehyde (16)Dihydroxybenzamide (6)Dihydroxybenzoate (14)Dihydroxybenzoic (17)Dihydroxybenzonitrile (6)Dihydroxyphenyl (90)Dihydroxystyryl (4)Diiodophenol (6)Fluorophenol (73)Hydroxyacetophenone (16)Hydroxybenzaldehyde (88)Hydroxybenzamide (24)Hydroxybenzenesulfonic (4)Hydroxybenzenesulfonic Acid (3)Hydroxybenzoate (111)Hydroxybenzohydrazide (4)Hydroxybenzoic (87)Hydroxybenzonitrile (60)Hydroxybenzoyl (1)Hydroxyphenoxy (7)Hydroxyphenylacetic (6)Hydroxyphenylacetic Acid (6)Hydroxyphenylboronic (8)Hydroxypropiophenone (3)Iodophenol (42)Nitrophenol (134)Tetrafluorophenol (10)Trifluorophenol (5)Trihydroxybenzaldehyde (5)Trihydroxybenzoate (12)Trihydroxybenzoic (5)Trihydroxybenzoic Acid (4)Trihydroxyphenyl (10)1,2,3,4-Tetrahydroisoquinolin-5-Ol (3)1,2,3,4-Tetrahydroisoquinolin-6-Ol (6)1-(2-Hydroxyphenyl)Ethan-1-One (72)1-(3-Hydroxyphenyl)Ethan-1-One (19)1-Hydroxyanthracene-9,10-Dione (12)2,3-Dichlorophenol (9)2,3-Difluorophenol (36)2,4-Dibromophenol (16)2,4-Difluorophenol (21)2,5-Dichlorophenol (7)2,6-Dibromophenol (20)2,6-Dichlorophenol (16)2,6-Difluorophenol (23)2,6-Diiodophenol (9)2,6-Dimethylphenol (19)2-(2-Hydroxyphenyl)Acetic Acid (8)2-(3-Hydroxyphenyl)Acetic Acid (7)2-(Benzyloxy)Phenol (5)2-(Difluoromethoxy)Phenol (5)2-(Tert-Butyl)Phenol (54)2-(Trifluoromethoxy)Phenol (8)2-(Trifluoromethyl)Phenol (23)2-Amino-3-Bromophenol (3)2-Amino-3-Chlorophenol (4)2-Aminophenol (106)2-Benzylphenol (8)2-Bromo-3-Methylphenol (4)2-Bromo-6-Methylphenol (7)2-Bromobenzene-1,3-Diol (7)2-Bromobenzene-1,4-Diol (4)2-Chloro-4-Fluorophenol (9)2-Chloro-4-Nitrophenol (5)2-Chloro-6-Methylphenol (5)2-Chloro-6-Nitrophenol (7)2-Chlorobenzene-1,3-Diol (4)2-Chlorophenol (163)2-Ethylphenol (10)2-Hydroxy-N-Phenylbenzamide (3)2-Hydroxybenzamide (14)2-Hydroxybenzonitrile (45)2-Iodobenzene-1,3-Diol (3)2-Iodophenol (53)2-Isopropylphenol (28)2-Methoxyphenol (196)3,4-Dibromophenol (3)3,4-Difluorophenol (19)3-(Benzyloxy)Phenol (5)3-(Trifluoromethoxy)Phenol (12)3-(Trifluoromethyl)Phenol (43)3-Bromo-2-Fluorophenol (5)3-Bromo-4-Chlorophenol (5)3-Bromo-4-Fluorophenol (11)3-Bromobenzene-1,2-Diol (8)3-Chloro-4-Hydroxybenzaldehyde (7)3-Chlorobenzene-1,2-Diol (6)3-Chlorophenol (112)3-Fluorophenol (177)3-Hydroxybenzonitrile (40)3-Iodophenol (21)3-Nitrobenzene-1,2-Diol (6)3-Nitrophenol (72)4-(Benzyloxy)Phenol (2)4-(Trifluoromethyl)Phenol (18)4-Amino-2-Fluorophenol (9)4-Amino-3-Chlorophenol (5)4-Benzylphenol (14)4-Chlorobenzene-1,3-Diol (6)4-Fluorophenol (111)4-Hydroxybenzenesulfonic Acid (5)4-Nitrobenzene-1,3-Diol (5)4-Nitrophenol (67)6-Hydroxy-2,3-Dihydro-1H-Inden-1-One (3)Ethyl 2-Hydroxybenzoate (18)Ethyl 3-Hydroxybenzoate (11)M-Cresol (144)Methyl 2-(4-Hydroxyphenyl)Acetate (10)Methyl 2-Hydroxybenzoate (74)Methyl 3-Hydroxybenzoate (57)O-Cresol (163)P-Cresol (71)Pyrocatechol (125)Resorcinol (145)
Phosphoruses (831)
Aryls (9)Esters (5)Fluorinated Building Blocks (5)Diethoxyphosphoryl (5)Diisopropylphosphoramidite (4)Dimethoxyphosphoryl (4)Dimethylphosphine (28)Dioxaphosphepine (146)Diphosphonic (9)Phosphorothioate (1)1,1,1-Trifluoro-N-(4-Oxido-2,6-Diphenyldinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepin-4-Yl)Methanesulfonamide (16)Diethyl Benzylphosphonate (17)Dimethyl(Phenyl)Phosphine Oxide (20)Ethyltriphenylphosphonium (2)Methyltriphenylphosphonium (2)Phenyl Phosphate (3)Phenylphosphonic Acid (6)
Polycyclic Aromatic Hydrocarbons (1)
Protective Groups (21)
Saturated Aliphatic Fused Rings (4)
(8Ar,12Br,14Br)-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene (4)
Silicon Compounds (448)
Butyldimethylsilyl (95)Butyldimethylsilyloxy (8)Dimethylsilane (16)Dimethylsilyl (4)Tetramethyldisiloxane (3)Triethoxysilyl (13)Triisopropylsilyl (22)Trimethoxysilane (19)Trimethylsilane (155)1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine (8)Tert-Butyldimethyl(Phenoxy)Silane (17)Tetraphenylsilane (7)Trimethoxy(Phenyl)Silane (6)Trimethyl(Phenyl)Silane (22)Trimethyl(Phenylethynyl)Silane (23)
Sulfamides (10232)
Alcohols (27)Aldehydes (6)Aliphatic Chain Hydrocarbons (37)Aliphatic Cyclic Hydrocarbons (8)Alkenyls (12)Amides (43)Amines (50)Aryls (216)Azetidines (5)Benzothiazoles (6)Benzyl Bromides (3)Bromides (35)Carboxylic Acids (28)Chlorides (50)Esters (23)Ethers (22)Fluorinated Building Blocks (26)Hydrazines (4)Imidazoles (7)Indoles (6)Ketones (4)Morpholines (11)Nitriles (4)Nitroes (7)Piperazines (12)Piperidines (24)Pyrazoles (4)Pyridines (19)Pyrimidines (1)Pyrrolidines (10)Sulfonates (6)Thiadiazoles (4)Thiophenes (16)Trifluoromethyls (5)Ureas (3)Other Aliphatic Heterocycles (11)Other Aromatic Heterocycles (17)Dimethylsulfamoyl (5)Methanesulfonamide (49)Methylmethanesulfonamide (3)Methylsulfonamido (4)Sulfinamide (55)2-Fluoro-N-Phenylbenzenesulfonamide (6)2-Fluorobenzenesulfonamide (12)2-Methylbenzenesulfonamide (8)3-Nitrobenzenesulfonamide (8)4-Amino-N-Phenylbenzenesulfonamide (3)4-Bromo-N-Phenylbenzenesulfonamide (23)4-Chloro-N-Phenylbenzenesulfonamide (4)4-Methoxy-N-Phenylbenzenesulfonamide (3)4-Methoxybenzenesulfonamide (5)4-Methyl-N-Phenylbenzenesulfonamide (13)N,N-Diethylbenzenesulfonamide (8)N,N-Dimethylbenzenesulfonamide (23)N-(2-Phenoxyphenyl)Methanesulfonamide (3)N-(3-Chlorophenyl)Benzenesulfonamide (6)N-(O-Tolyl)Benzenesulfonamide (4)N-(Tert-Butyl)Benzenesulfonamide (14)N-Ethylbenzenesulfonamide (8)N-Isopropylbenzenesulfonamide (8)N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide (7)N-Methylbenzenesulfonamide (15)N-Phenylbenzenesulfonamide (81)N-Phenylmethanesulfonamide (37)Phenylmethanesulfonamide (13)Pyridine-2-Sulfonamide (6)
Sulfides (10154)
Alcohols (27)Aldehydes (8)Aliphatic Chain Hydrocarbons (28)Amides (40)Amines (41)Aryls (143)Benzimidazoles (7)Bromides (18)Carboxylic Acids (57)Chlorides (50)Esters (27)Ethers (29)Fluorinated Building Blocks (21)Furans (6)Ketones (18)Nitriles (13)Nitroes (12)Phenols (3)Pyridines (18)Pyrimidines (53)Pyrrolidines (7)Tetrahydropyrans (3)Thiadiazoles (7)Thiazoles (8)Thiophenes (4)Triazoles (3)Other Aliphatic Heterocycles (8)Other Aromatic Heterocycles (8)Methylthio (424)(S)-2-(Phenylthio)Tetrahydro-2H-Pyran (5)1,2-Diphenyldisulfane (18)2-((Pyridin-2-Ylmethyl)Thio)-1H-Benzo[D]Imidazole (7)2-(Methylthio)Benzo[D]Thiazole (6)2-(Methylthio)Pyridine (5)2-(Methylthio)Pyrimidin-4-Amine (10)2-(Methylthio)Pyrimidine (19)2-(Methylthio)Thiazole (5)2-(Propylthio)Pyrimidine (5)4,6-Dichloro-2-(Methylthio)Pyrimidine (9)4-Chloro-2-(Methylthio)Pyrimidine (29)4-Methyl-2-(Methylthio)Pyrimidine (7)5-Bromo-2-(Methylthio)Pyrimidine (6)Benzyl(Phenyl)Sulfane (5)Ethyl(Phenyl)Sulfane (8)Pentafluoro(Phenyl)-L6-Sulfane (19)Phenyl(Trifluoromethyl)Sulfane (23)
Sulfonates (1153)
Aliphatic Chain Hydrocarbons (4)Amides (15)Amines (6)Aryls (83)Dioxolanes (4)Epoxides (7)Ethers (4)Fluorinated Building Blocks (23)Nitroes (6)Oxetanes (5)Piperidines (10)Pyrrolidines (4)Sulfamides (6)Trifluoromethyls (14)4-Methylbenzenesulfonate (8)
Sulfones (3920)
Alcohols (7)Aliphatic Chain Hydrocarbons (18)Alkenyls (12)Amides (13)Amines (20)Aryls (118)Bromides (31)Carboxylic Acids (15)Chlorides (29)Esters (16)Ethers (12)Fluorinated Building Blocks (13)Ketones (9)Nitriles (9)Phenols (5)Piperazines (1)Piperidines (6)Pyridines (14)Pyrimidines (7)Thiomorpholines (8)Thiophenes (4)Other Aliphatic Heterocycles (9)Other Aromatic Heterocycles (5)(4-(Methylsulfonyl)Phenyl)Boronic Acid (6)(Ethylsulfonyl)Benzene (8)1-(Methylsulfonyl)-3-Nitrobenzene (7)1-(Methylsulfonyl)Piperazine (5)1-(Methylsulfonyl)Piperidine (5)1-(Phenylsulfonyl)-1H-1,2,4-Triazole (6)1-(Phenylsulfonyl)-1H-Imidazole (5)1-(Phenylsulfonyl)Azetidine (7)1-Bromo-2-(Methylsulfonyl)Benzene (4)1-Bromo-4-(Phenylsulfonyl)Benzene (7)1-Fluoro-2-(Methylsulfonyl)Benzene (5)1-Fluoro-3-(Methylsulfonyl)Benzene (10)1-Methyl-3-(Methylsulfonyl)Benzene (5)2-(Methylsulfonyl)Aniline (3)2-(Methylsulfonyl)Pyridine (11)2-(Methylsulfonyl)Pyrimidine (25)3-(Methylsulfonyl)Aniline (7)3-(Methylsulfonyl)Benzoic Acid (6)3-(Methylsulfonyl)Pyridine (5)Benzenesulfonyl Fluoride (50)Tetrahydro-2H-Thiopyran 1,1-Dioxide (8)Tetrahydrothiophene 1,1-Dioxide (13)
Sulfonic Acids (1259)
Aliphatic Cyclic Hydrocarbons (4)Amines (11)Aryls (22)Ketones (4)Aminobenzenesulfonic (4)Bromobenzenesulfonic Acid (4)Disulfonic (9)Ethanesulfonic (3)Methanesulfonic (2)Methylbenzenesulfonate (142)Propanesulfonic Acid (2)2-Aminobenzenesulfonic Acid (9)2-Methylbenzenesulfonic Acid (8)3-Aminobenzenesulfonic Acid (6)4-Chlorobenzenesulfonic Acid (4)4-Hydroxybenzenesulfonic Acid (5)Naphthalene-2-Sulfonic Acid (4)Pyridine-3-Sulfonic Acid (6)
Sulfonyl Chlorides (4009)
Aliphatic Chain Hydrocarbons (19)Aliphatic Cyclic Hydrocarbons (8)Aryls (57)Bromides (17)Ethers (19)Nitriles (5)Piperidines (4)Pyrazoles (4)Pyridines (5)Quinolines (6)Thiophenes (5)Fluorobenzenesulfonyl (12)1H-Pyrazole-4-Sulfonyl Chloride (8)2-Bromobenzenesulfonyl Chloride (8)2-Chlorobenzenesulfonyl Chloride (24)2-Fluorobenzenesulfonyl Chloride (31)2-Methoxybenzenesulfonyl Chloride (15)2-Methylbenzenesulfonyl Chloride (22)3-(Chlorosulfonyl)Benzoic Acid (15)3-(Trifluoromethyl)Benzenesulfonyl Chloride (13)3-Chlorobenzenesulfonyl Chloride (21)3-Fluorobenzenesulfonyl Chloride (22)4-Chlorobenzenesulfonyl Chloride (12)4-Fluorobenzenesulfonyl Chloride (26)Isoquinoline-5-Sulfonyl Chloride (3)Methyl 2-(Chlorosulfonyl)Benzoate (7)Phenylmethanesulfonyl Chloride (20)
Sulfonyl Hydrazides (25)
Benzenesulfonohydrazide (12)
Sulfoxides (334)
Aryls (19)Chlorides (7)Ethers (5)(Methylsulfinyl)Benzene (7)
Thioesters (624)
Aliphatic Chain Hydrocarbons (4)Amides (25)Amines (5)Aryls (9)Benzothiazoles (12)Carboxylic Acids (7)Fluorinated Building Blocks (4)Thiazolidines (8)
Thiols (472)
Alcohols (5)Aliphatic Chain Hydrocarbons (27)Amides (4)Aryls (8)Esters (9)Dithiole (9)Ethanethioate (9)Methanethiol (6)1H-Benzo[D]Imidazole-2-Thiol (10)2-Chlorobenzenethiol (7)2-Mercaptoquinazolin-4(3H)-One (3)Benzo[D]Oxazole-2-Thiol (6)Benzo[D]Thiazole-2-Thiol (11)Phenylmethanethiol (16)Pyridine-2-Thiol (8)Pyrimidine-2-Thiol (6)
Thiophenols (3052)
Amides (6)Amines (5)Aryls (29)Bromides (4)Ethers (7)Fluorinated Building Blocks (4)Pyridines (6)Pyrimidines (4)Thiadiazoles (6)Thiazoles (4)Triazoles (8)
Thioureas (1119)
Aliphatic Chain Hydrocarbons (19)Amides (61)Aryls (28)Hydrazides (11)Hydrazines (8)Pyridines (4)Carbamimidothioate (4)1,3-Diphenylthiourea (8)1-Phenylthiourea (33)
Trifluoromethyls (28901)
Alcohols (71)Aldehydes (10)Aliphatic Chain Hydrocarbons (67)Aliphatic Cyclic Hydrocarbons (19)Alkenyls (5)Amides (74)Amidines (3)Amines (95)Aryls (259)Bromides (94)Carboxylic Acids (71)Chlorides (61)Esters (70)Ethers (107)Fluorinated Building Blocks (496)Hydrazines (4)Imidazoles (12)Indoles (5)Iodides (14)Ketones (41)Morpholines (5)Nitriles (13)Nitroes (5)Phenols (2)Piperazines (7)Piperidines (8)Pyrazines (5)Pyrazoles (26)Pyridines (39)Pyrimidines (6)Pyrroles (4)Pyrrolidines (4)Quinolines (7)Sulfamides (5)Sulfonates (14)Thiophenes (1)Other Aromatic Heterocycles (18)Trifluoromethyl-Picolinamide (7)Trifluoromethylaniline (3)Trifluoromethylphenol (16)(2,2,2-Trifluoroethoxy)Benzene (18)(2-(Trifluoromethoxy)Phenyl)Boronic Acid (5)(2-(Trifluoromethyl)Phenyl)Boronic Acid (20)(2-(Trifluoromethyl)Phenyl)Methanol (10)(2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (6)(3-(Trifluoromethoxy)Phenyl)Boronic Acid (9)(3-(Trifluoromethoxy)Phenyl)Methanol (4)(3-(Trifluoromethyl)Phenyl)Boronic Acid (41)(3-(Trifluoromethyl)Phenyl)Methanol (22)(4-(Trifluoromethyl)Phenyl)Boronic Acid (23)(Perfluoropropane-2,2-Diyl)Dibenzene (7)(Trifluoromethyl)Benzene (1314)1,3-Bis(Trifluoromethyl)Benzene (70)1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One (9)1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine (25)1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine (6)1-(Bromomethyl)-2-(Trifluoromethyl)Benzene (13)1-(Bromomethyl)-3-(Trifluoromethyl)Benzene (17)1-Bromo-2-(Trifluoromethoxy)Benzene (22)1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene (4)1-Bromo-3-(Trifluoromethyl)Benzene (100)1-Chloro-2-(Trifluoromethoxy)Benzene (20)1-Chloro-2-(Trifluoromethyl)Benzene (81)1-Chloro-3-(Trifluoromethoxy)Benzene (18)1-Chloro-3-(Trifluoromethyl)Benzene (101)1-Chloro-4-(Trifluoromethoxy)Benzene (8)1-Fluoro-2-(Trifluoromethoxy)Benzene (20)1-Fluoro-2-(Trifluoromethyl)Benzene (125)1-Fluoro-3-(Trifluoromethyl)Benzene (98)1-Fluoro-4-(Trifluoromethoxy)Benzene (14)1-Fluoro-4-(Trifluoromethyl)Benzene (53)1-Iodo-2-(Trifluoromethyl)Benzene (13)1-Iodo-3-(Trifluoromethyl)Benzene (30)1-Methoxy-2-(Trifluoromethyl)Benzene (21)1-Methoxy-3-(Trifluoromethoxy)Benzene (9)1-Methoxy-3-(Trifluoromethyl)Benzene (40)1-Methoxy-4-(Trifluoromethyl)Benzene (18)1-Methyl-2-(Trifluoromethoxy)Benzene (5)1-Methyl-2-(Trifluoromethyl)Benzene (43)1-Methyl-3-(Trifluoromethyl)Benzene (22)1-Nitro-2-(Trifluoromethoxy)Benzene (8)1-Nitro-2-(Trifluoromethyl)Benzene (32)1-Nitro-3-(Trifluoromethoxy)Benzene (9)1-Nitro-3-(Trifluoromethyl)Benzene (82)1-Phenoxy-3-(Trifluoromethyl)Benzene (2)1-Phenoxy-4-(Trifluoromethyl)Benzene (2)1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole (5)2,2,2-Trifluoro-1-Phenylethan-1-Amine (48)2,2,2-Trifluoro-1-Phenylethan-1-Ol (27)2,2,2-Trifluoro-1-Phenylethan-1-One (51)2-(2,2,2-Trifluoroethoxy)Pyridine (8)2-(Trifluoromethoxy)Aniline (18)2-(Trifluoromethoxy)Benzaldehyde (7)2-(Trifluoromethoxy)Benzoic Acid (8)2-(Trifluoromethoxy)Benzonitrile (7)2-(Trifluoromethoxy)Phenol (8)2-(Trifluoromethoxy)Pyridine (6)2-(Trifluoromethyl)-1,1'-Biphenyl (8)2-(Trifluoromethyl)Aniline (58)2-(Trifluoromethyl)Benzaldehyde (27)2-(Trifluoromethyl)Benzamide (6)2-(Trifluoromethyl)Benzoic Acid (33)2-(Trifluoromethyl)Benzonitrile (35)2-(Trifluoromethyl)Phenol (23)2-(Trifluoromethyl)Pyrazine (6)2-(Trifluoromethyl)Pyridine (6)2-(Trifluoromethyl)Pyrimidine (27)2-(Trifluoromethyl)Quinazoline (4)2-(Trifluoromethyl)Thiazole (11)2-(Trifluoromethyl)Thiophene (10)2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene (4)2-Bromo-4-(Trifluoromethyl)Aniline (9)2-Bromo-6-(Trifluoromethyl)Aniline (5)2-Chloro-3-(Trifluoromethyl)Aniline (3)2-Chloro-4-(Trifluoromethyl)Pyrimidine (6)2-Chloro-6-(Trifluoromethyl)Aniline (4)2-Methoxy-3-(Trifluoromethyl)Pyridine (6)2-Methoxy-5-(Trifluoromethyl)Pyridine (4)2-Phenoxy-5-(Trifluoromethyl)Pyridine (7)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine (3)3-(Trifluoromethoxy)Aniline (22)3-(Trifluoromethoxy)Benzaldehyde (10)3-(Trifluoromethoxy)Benzoic Acid (19)3-(Trifluoromethoxy)Benzonitrile (11)3-(Trifluoromethoxy)Phenol (12)3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine (3)3-(Trifluoromethyl)Aniline (102)3-(Trifluoromethyl)Benzaldehyde (31)3-(Trifluoromethyl)Benzenesulfonyl Chloride (13)3-(Trifluoromethyl)Benzoic Acid (52)3-(Trifluoromethyl)Benzonitrile (47)3-(Trifluoromethyl)Phenol (43)3-(Trifluoromethyl)Pyridazine (3)3-(Trifluoromethyl)Pyridin-2-Ol (5)3-(Trifluoromethyl)Pyridine (51)3-Chloro-4-(Trifluoromethyl)Aniline (5)4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione (10)4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane (5)4-(Trifluoromethoxy)Aniline (26)4-(Trifluoromethyl)-2H-Chromen-2-One (7)4-(Trifluoromethyl)Phenol (18)4-(Trifluoromethyl)Pyridine (14)4-(Trifluoromethyl)Pyrimidin-2-Amine (6)4-(Trifluoromethyl)Pyrimidine (12)4-(Trifluoromethyl)Thiazole (7)4-Bromo-3-(Trifluoromethyl)Aniline (7)5-(Trifluoromethyl)Pyridin-2-Amine (5)5-(Trifluoromethyl)Pyridin-2-Ol (8)6-(Trifluoromethyl)-1H-Indazole (6)6-(Trifluoromethyl)-1H-Indole (5)6-(Trifluoromethyl)Pyridin-2-Amine (11)6-(Trifluoromethyl)Pyridin-3-Amine (5)Methyl 2-(Trifluoromethyl)Benzoate (14)Methyl 3-(Trifluoromethyl)Benzoate (22)N-Phenyl-4-(Trifluoromethyl)Aniline (3)Phenyl(3-(Trifluoromethyl)Phenyl)Methanone (3)Phenyl(Trifluoromethyl)Sulfane (23)
Ureas (1847)
Alcohols (5)Aliphatic Chain Hydrocarbons (28)Aliphatic Cyclic Hydrocarbons (6)Amides (80)Amines (6)Aryls (28)Carboxylic Acids (3)Chlorides (7)Hydrazides (7)Hydrazines (4)Morpholines (4)Piperazines (5)Pyrrolidines (2)Sulfamides (3)
Other Function Groups (2)
Organocatalysts
Chiral Hydrogen-Bonding Organocatalysts (76)
Chiral Phosphoric Acids (190)
4-Hydroxy-2,6-Diphenyldinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepine 4-Oxide (20)
Chiral Squaramides Organocatalysts (14)
Chiral Thiourea Catalyst (36)
Cinchona Alkaloids (32)
MacMillan Imidazolidinone Organocatalysts (11)
NHTf (59)
Proline-Based Organocatalysts (51)
Other Organocatalysts (47)
Organometallic Reagents
Organoborons (34434)
Fluorene-Phenyl-Boronic Acid/Ester (4)Hydroxymethyl-Phenyl-Boronic-Acid (32)Methoxyphenylboronic-Acid (32)Phenyl-Naphthalene-Boronic Acid/Ester (9)(1-(Tert-Butoxycarbonyl)-1H-Indol-2-Yl)Boronic Acid (17)(1-Phenyl-1H-Pyrazol-4-Yl)Boronic Acid (4)(1H-Indazol-4-Yl)Boronic Acid (3)(1H-Indazol-6-Yl)Boronic Acid (4)(1H-Indol-2-Yl)Boronic Acid (3)(2,3-Dichlorophenyl)Boronic Acid (11)(2,3-Difluorophenyl)Boronic Acid (33)(2,6-Dichlorophenyl)Boronic Acid (6)(2,6-Difluorophenyl)Boronic Acid (28)(2-(Phenoxymethyl)Phenyl)Boronic Acid (3)(2-(Trifluoromethoxy)Phenyl)Boronic Acid (5)(2-(Trifluoromethyl)Phenyl)Boronic Acid (20)(2-Bromophenyl)Boronic Acid (39)(2-Chloro-3-Methoxyphenyl)Boronic Acid (5)(2-Chloro-6-Fluorophenyl)Boronic Acid (9)(2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (6)(2-Fluorophenyl)Boronic Acid (229)(2-Nitrophenyl)Boronic Acid (13)(3,4-Dichlorophenyl)Boronic Acid (10)(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanol (7)(3-(Benzyloxy)Phenyl)Boronic Acid (9)(3-(Phenoxymethyl)Phenyl)Boronic Acid (3)(3-(Phenylcarbamoyl)Phenyl)Boronic Acid (3)(3-(Trifluoromethoxy)Phenyl)Boronic Acid (9)(3-(Trifluoromethyl)Phenyl)Boronic Acid (41)(3-Bromo-2-Fluorophenyl)Boronic Acid (7)(3-Bromo-2-Methoxyphenyl)Boronic Acid (6)(3-Bromophenyl)Boronic Acid (65)(3-Chloro-2-Methoxyphenyl)Boronic Acid (4)(3-Chloro-4-Fluorophenyl)Boronic Acid (8)(3-Chlorophenyl)Boronic Acid (121)(3-Fluorophenyl)Boronic Acid (169)(3-Iodophenyl)Boronic Acid (5)(3-Nitrophenyl)Boronic Acid (32)(4-(Benzyloxy)Phenyl)Boronic Acid (26)(4-(Methylsulfonyl)Phenyl)Boronic Acid (6)(4-(Phenoxymethyl)Phenyl)Boronic Acid (6)(4-(Phenylcarbamoyl)Phenyl)Boronic Acid (11)(4-(Trifluoromethyl)Phenyl)Boronic Acid (23)(4-Cyclohexylphenyl)Boronic Acid (7)(4-Fluorophenyl)Boronic Acid (93)(5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid (4)(6-Phenoxypyridin-3-Yl)Boronic Acid (5)(9H-Fluoren-2-Yl)Boronic Acid (6)(E)-4,4,5,5-Tetramethyl-2-Styryl-1,3,2-Dioxaborolane (16)1,3,2-Dioxaborinane (6)1-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazine (6)1-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole (6)2,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-9H-Fluorene (7)2-(1,3,2-Dioxaborinan-2-Yl)Benzonitrile (4)2-(1,3,2-Dioxaborolan-2-Yl)-1-Methyl-1H-Indole (6)2-(2-(Bromomethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (9)2-(2-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(3-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(3-Cyclopropylphenyl)-1,3,2-Dioxaborolane (5)2-(3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (5)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (14)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol (7)2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-(4-(Benzyloxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (10)2-(4-Bromophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (8)2-(4-Cyclopropylphenyl)-1,3,2-Dioxaborolane (8)2-(4-Fluorophenyl)-1,3,2-Dioxaborinane (5)2-([1,1'-Biphenyl]-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (10)2-(Cyclohex-1-En-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (16)2-(Furan-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (6)2-(M-Tolyl)-1,3,2-Dioxaborinane (4)2-Benzyl-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane (12)2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (4)2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (14)2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (3)3-(1,3,2-Dioxaborinan-2-Yl)Aniline (3)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile (25)3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (74)3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (7)3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (6)4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(2-Nitrophenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane (5)4,4,5,5-Tetramethyl-2-(Naphthalen-1-Yl)-1,3,2-Dioxaborolane (19)4,4,5,5-Tetramethyl-2-(Naphthalen-2-Yl)-1,3,2-Dioxaborolane (12)4,4,5,5-Tetramethyl-2-(Thiophen-2-Yl)-1,3,2-Dioxaborolane (23)4,4,5,5-Tetramethyl-2-(Thiophen-3-Yl)-1,3,2-Dioxaborolane (10)4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine (11)4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine (5)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indoline (5)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile (4)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine (9)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine (27)5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole (7)[1,1'-Biphenyl]-4-Ylboronic Acid (29)Benzo[B]Thiophen-2-Ylboronic Acid (5)Benzofuran-2-Ylboronic Acid (8)Benzyl (4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Carbamate (5)Cyclohex-1-En-1-Ylboronic Acid (4)Ethyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate (6)Isoquinolin-4-Ylboronic Acid (3)Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate (4)N,N-Diphenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline (6)Naphthalen-1-Ylboronic Acid (4)Naphthalen-2-Ylboronic Acid (8)Phenylboronic Acid (1287)Pyridin-2-Ylboronic Acid (9)Pyridin-3-Ylboronic Acid (49)Pyridin-4-Ylboronic Acid (21)Pyrimidin-5-Ylboronic Acid (9)Tert-Butyl 2-(1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate (6)Tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole-1-Carboxylate (3)Tetraphenylborate (8)Thiophen-2-Ylboronic Acid (20)
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Pharmaceutical Intermediate
Analgesics
Benzhydrocodone (1)
Bicifadine (1)
Capsaicin (12)
Celecoxib Related (7)
Debio-0827 (2)
Elagolix Related (21)
Esketamine Hydrochloride (3)
Ibuprofen sodium (7)
Nalbuphine Sebacate (1)
Oliceridine fumarate (6)
Oxycodone (2)
Parecoxib  (6)
Tapentadol  (14)
Zucapsaicin Related (6)
Anesthetics
Ciprofol (7)
Esketamine Hydrochloride (3)
Fospropofol (3)
Remimazolam (11)
Anti-Addiction Agents
Kakonein (2)
Lofexidine Hydrochloride (2)
Anti-Inflammatory Agents
Apremilast (16)
Asunaprevir Related (20)
ATB-346 Related (2)
Baricitinib Related (13)
Bencycloquidium Bromide (2)
Cefiderocol Sulfate Tosylate (4)
Ceftaroline Fosamil Acetate (6)
Ceftobiprole Medocaril Sodium (4)
Celecoxib Related (7)
Cetirizine Hydrochloride (7)
Ciclesonide Related (3)
Ciprofloxacin (8)
Coblopasvir hydrochloride (2)
Crisaborole (7)
Daclatasvir Related (14)
Danoprevir Sodium (6)
Daptomycin Related (15)
Dasabuvir Sodium Hydrate (19)
Desloratadine (17)
Duloxetine (14)
Eltrombopag Related (17)
Esflurbiprofen (1)
Esomeprazole Related (14)
Etoricoxib (5)
Fexofenadine Hydrochloride (8)
Filgotinib Related (6)
Flobufen (1)
Fluticasone Propionate (1)
Ganciclovir (3)
Glycopyrronium Bromide (15)
Grapiprant Related (1)
Iguratimod Related (9)
Imrecoxib Related (6)
Lefamulin (7)
Levocetirizine Dihydrochloride (7)
Licofelone Related (4)
Lumiracoxib (2)
Meloxicam Related (3)
Mesalazine (5)
Methotrexate (2)
Minocycline Hydrochloride (2)
Moxifloxacin Related (15)
Nemonoxacin Malate (20)
Olodaterol Hydrochloride (7)
Ozanimod hydrochloride (10)
Plazomicin sulfate (6)
Prulifloxacin Related (7)
Ravidasvir Related (14)
Remdesivir (10)
Rofecoxib Related (7)
Rupatadine Fumarate (14)
Simeprevir Sodium (9)
Sitafloxacin Related (20)
Sivelestat Related (7)
Sofosbuvir Related (20)
Telavancin (4)
Tenofovir Disoproxil Related (18)
Tofacitinib Citrate (18)
Upadacitinib (3)
Valganciclovir Related (10)
Vonoprazan (15)
Zidometacin (1)
Antibacterials
AFN-1252 Related (4)
Bedaquiline Fumarate (16)
Caspofungin (4)
Cefiderocol Sulfate Tosylate (4)
Ceftaroline Fosamil Acetate (6)
Ceftizoxime Alapivoxil (2)
Cethromycin Related (2)
Ciprofloxacin (8)
Daptomycin Related (15)
Delafloxacin Related (8)
Eravacycline Related (6)
Finafloxacin Related (15)
Garenoxacin (16)
Gemifloxacin Related (12)
Ibrexafungerp (3)
Isavuconazonium Sulfate Related (18)
Lefamulin (7)
Linezolid Related (11)
Luliconazole Related (6)
Methotrexate (2)
Minocycline Hydrochloride (2)
Morinidazole Related (3)
Moxifloxacin Related (15)
Nemonoxacin Malate (20)
Omadacycline Related (6)
Oritavancin Related (1)
Plazomicin sulfate (6)
Posaconazole Related (14)
Pretomanid (8)
Prulifloxacin Related (7)
Radezolid Related (4)
Relebactam Related (4)
Retapamulin Related (1)
Sarecycline Hydrochloride (2)
Secnidazole (5)
Sitafloxacin Related (20)
Solithromycin Related (3)
Surotomycin Related (1)
Tebipenem Pivoxil Related (13)
Tedizolid Related (17)
Telavancin (4)
Vonoprazan (15)
Voriconazole (13)
Zoliflodacin Related (1)
Anticonvulsants
Brivaracetam (10)
Escitalopram Related (17)
Eslicarbazepine Acetate Related (8)
Fosphenytoin (5)
Lacosamide (17)
Levetiracetam Related (13)
Perampanel Hydrate (22)
Pregabalin (9)
Retigabine/Ezogabine (4)
Tiagabine Related (5)
Antidementia Agents
Azeliragon Related (1)
Donepezil Related (13)
Florbetaben  (1)
Flortaucipir F 18 (7)
Flutemetamol  (4)
Idebenone (7)
Memantine Hydrochloride (5)
NTC-942 (2)
Semagacestat Related (4)
Verubecestat Related (1)
Antidepressants
4-Chlorokynurenine (2)
Agomelatine Related (10)
Amibegron (2)
Amitifadine (1)
Brexpiprazole Related (10)
Duloxetine (14)
Escitalopram Related (17)
Esketamine Hydrochloride (3)
Levomilnacipran  (2)
Olanzapine Related (7)
Quetiapine (6)
Rapastinel Related (1)
Vilazodone Hydrochloride (22)
Vortioxetine Related (5)
Antiemetics
Aprepitant Related (17)
Dolasetron Related (10)
Fosaprepitant Related (22)
Olanzapine Related (7)
Palonosetron Related (12)
Remimazolam (11)
Rolapitant Related (27)
Antifungals
Anidulafungin Related (4)
Cabotegravir Related (19)
Caspofungin (4)
Dolutegravir Sodium (29)
Doravirine Related (14)
Efinaconazole Related (9)
Fostemsavir Related (8)
Isavuconazonium Sulfate Related (18)
Luliconazole Related (6)
Methotrexate (2)
Posaconazole Related (14)
Rilpivirine Related (26)
Tavaborole (5)
Voriconazole (13)
VT-1161 (5)
Antigout Agents
Febuxostat Related (21)
Topiroxostat Related (2)
Antimigraine Agents
Celecoxib Related (7)
Lasmiditan Related (11)
Rimegepant sulfate (9)
Telcagepant Related (6)
Topiramate (6)
Ubrogepant Related (4)
Antineoplastics
Abemaciclib Related (14)
Abiraterone Acetate Related (5)
Acalabrutinib Related (14)
Acelarin Related (1)
Afatinib (23)
Afuresertib Related (4)
Alectinib Related (24)
Alisertib Related (8)
Almonertinib Mesilate (11)
Alpelisib Related (18)
Aminolevulinic Acid Hydrochloride (9)
Anamorelin Related (2)
Anlotinib Dihydrochloride (6)
Apalutamide (17)
Apatinib Related (6)
Apaziquone (2)
AR-42 Related (1)
ASLAN-002 (6)
Asoprisnil Related (1)
AT-7519 (1)
Avapritinib (16)
Axitinib Related (20)
Azacitidine (8)
BAL-101553 (2)
Batimastat Related (2)
Belinostat Related (16)
Bendamustine Hydrochloride (11)
Bexarotene Related (5)
Bicalutamide Related (5)
Binimetinib (17)
Birinapant Related (1)
Bortezomib Related (12)
Bosutinib (27)
Brigatinib (10)
Brivanib Alaninate Related (9)
Cabazitaxel Related (2)
Cabozantinib (16)
Capecitabine Related (14)
Capmatinib Hydrochloride (16)
Carfilzomib Related (17)
Cebranopadol Related (1)
Cediranib Related (4)
Ceritinib Related (18)
Chidamide Related (6)
Cinacalcet Related (15)
Cladribine (12)
Clofarabine Related (11)
Cobimetinib Related (18)
Copanlisib Related (11)
Cositecan (3)
Crenolanib Related (6)
Crizotinib Related (24)
Curcumin Related (1)
Dabrafenib Mesylate (10)
Dacomitinib Related (15)
Dactolisib (8)
Danusertib Related (3)
Darolutamide (7)
Dasatinib Related (22)
Decitabine Related (10)
Defactinib Related (4)
Degarelix Related (15)
Dinaciclib Related (3)
Disomotide (5)
Donafenib Tosylate (7)
Dovitinib Related (3)
Duvelisib Related (8)
Elagolix Related (21)
Elesclomol Related (2)
Enasidenib Related (8)
Encorafenib Related (17)
ENMD-2076 Related (1)
Enobosarm (2)
Ensartinib Hydrochloride (7)
Entinostat Related (3)
Entrectinib Related (9)
Enzalutamide Related (14)
Epacadostat Related (4)
Erdafitinib (17)
Eribulin Related (25)
Everolimus (5)
Flumatinib Mesylate (4)
Fostamatinib Related (6)
Fulvestrant Related (5)
Gadobutrol (8)
Galunisertib (6)
GDC-0810 Related (3)
Gefitinib Related (13)
Gemcitabine Related (13)
Gilteritinib Related (5)
Glasdegib (11)
Guadecitabine Related (1)
Ibrutinib Related (11)
Icotinib Related (13)
Idelalisib (12)
Imiquimod Related (18)
Infigratinib (6)
Irinotecan hydrochloride (12)
Ivosidenib (5)
Ixabepilone Related (3)
Ixazomib Citrate Related (6)
Lapatinib Related (21)
Larotrectinib sulfate (11)
Lenalidomide Related (14)
Lenvatinib Related (16)
Linifanib Related (6)
Lonafarnib (19)
Lorlatinib (16)
Melphalan (4)
Mercaptopurine (7)
Methotrexate (2)
Midostaurin (3)
Mitomycin  (1)
Motesanib Related (2)
Naquotinib Related (1)
Nastorazepide Related (3)
Neratinib Related (23)
Nilotinib Related (6)
Nintedanib (17)
Niraparib (25)
Nolatrexed (5)
Obatoclax Related (2)
ODM-201 Related (3)
Oglufanide Related (4)
Olaparib Related (9)
Olmutinib Related (3)
Omacetaxine Mepesuccinate (3)
Oprozomib Related (2)
Orteronel Related (6)
Osimertinib Related (23)
Paclitaxel (1)
Pacritinib Related (5)
Palbociclib Related (29)
Pamiparib (7)
Panobinostat Related (7)
PD-0325901 (2)
Pemetrexed Related (18)
Pemigatinib (23)
Perifosine Related (2)
Pexidartinib Related (7)
Piflufolastat F 18 (7)
Pimasertib (2)
Pixantrone Related (2)
Plerixafor Related (6)
Pomalidomide Related (12)
Ponatinib Related (14)
Pralatrexate Related (14)
Pyrotinib Maleate (6)
Radotinib Related (2)
Regorafenib Monohydrate (9)
Relugolix (12)
Ribociclib Succinate (11)
Rigosertib Related (3)
Ripretinib (11)
Rociletinib  (4)
Romidepsin Related (8)
Rucaparib Related (21)
Ruxolitinib Related (18)
Seliciclib (1)
Selpercatinib (21)
Selumetinib sulfate (12)
Semaxanib (1)
Sirolimus (1)
Sonidegib (10)
Sorafenib  (12)
Sotrastaurin Related (3)
Sunitinib Related (19)
Surufatinib (5)
Talaporfin  (1)
Talazoparib (12)
Tamibarotene Related (4)
Tasisulam Related (2)
Tasquinimod Related (5)
Tazemetostat Hydrobromide (8)
Telatinib Related (3)
Telotristat Related (17)
Temozolomide Related (7)
Tepotinib hydrochloride hydrate (6)
Thalidomide Related (10)
Tipifarnib Related (1)
Tivantinib Related (6)
Tivozanib Related (10)
Trabectedin Related (12)
Trametinib Related (12)
Tucatinib (9)
Uridine Triacetate (4)
Vadimezan (2)
Vandetanib Related (27)
Vemurafenib Related (24)
Venetoclax (26)
Vismodegib Related (12)
Volasertib Related (7)
Volitinib (2)
Vorinostat Related (8)
Vosaroxin (9)
Zanubrutinib (11)
Zoledronic Acid Hydrate (4)
Zosuquidar Related (2)
ZSTK-474 (3)
Antiparasitics
Abametapir (3)
Artefenomel Related (2)
Moxidectin (1)
Nitazoxanide Related (1)
Tafenoquine Related (23)
Antiparkinson Agents
Apomorphine Hydrochloride (5)
Dipraglurant Related (2)
Entacapone Related (2)
Istradefylline Related (8)
Opicapone Related (12)
Rasagiline Related (13)
Ropinirole Related (22)
Rotigotine (10)
Safinamide Related (14)
Tolcapone Related (3)
Tozadenant Related (7)
Antipsychotics
Aripiprazole Related (6)
Asenapine Related (13)
Bitopertin Related (3)
Blonanserin (4)
Brexpiprazole Related (10)
Cariprazine Related (11)
Loxapine (4)
Lurasidone  (9)
Neboglamine (2)
Olanzapine Related (7)
Paliperidone Related (5)
Pimavanserin Related (9)
Quetiapine (6)
Raclopride (2)
Risperidone (7)
Ziprasidone (9)
Antispasticity Agents
Arbaclofen (4)
Florbetapir (7)
Tiotropium Bromide Hydrate (1)
Antivirals
Adefovir Dipivoxil Related (1)
Asunaprevir Related (20)
Baloxavir Marboxil (29)
Beclabuvir Related (8)
BIT-225 (1)
Boceprevir (11)
Brincidofovir (10)
Cabotegravir Related (19)
Clevudine Related (1)
Cobicistat Related (3)
Daclatasvir Related (14)
Dasabuvir Sodium Hydrate (19)
Dolutegravir Sodium (29)
Doravirine Related (14)
Efavirenz Related (6)
Elbasvir Related (3)
Elvitegravir (11)
Emtricitabine Related (2)
Faldaprevir (10)
Favipiravir (13)
Fostemsavir Related (8)
Ganciclovir (3)
Lamivudine Related (3)
Ledipasvir Related (17)
Letermovir (5)
Lobucavir (3)
Maraviroc Related (14)
Nelfinavir Related (5)
Nevirapine Related (10)
Ombitasvir Related (4)
Paritaprevir Related (1)
Peramivir Related (13)
Ravidasvir Related (14)
Remdesivir (10)
Ritonavir Related (7)
Saquinavir Related (1)
Simeprevir Sodium (9)
Sofosbuvir Related (20)
Telaprevir (13)
Telbivudine Related (4)
Tenofovir Disoproxil Related (18)
V-116517 (2)
Valacyclovir Related (5)
Valganciclovir Related (10)
Vedroprevir (2)
Vicriviroc (6)
Zanamivir Related (12)
Anxiolytics
Dexmedetomidine Hydrochloride (10)
Duloxetine (14)
Escitalopram Related (17)
Osemozotan (2)
Pregabalin (9)
Zatosetron (2)
Blood Glucose Regulators
Allisartan Isoproxil  (9)
Alogliptin Related (11)
Anagliptin Related (2)
Azilsartan Related (21)
Balaglitazone Related (2)
Bempedoic Acid (6)
Bexagliflozin Related (1)
Bosentan Related (14)
Canagliflozin (17)
Dapagliflozin Related (14)
Denagliptin Related (1)
Dutogliptin Related (4)
Empagliflozin Related (20)
Ertugliflozin (23)
Evogliptin Related (6)
Fasiglifam (10)
Gemigliptin Related (4)
Glimepiride Related (2)
Ipragliflozin Related (5)
Lacosamide (17)
Linagliptin Related (12)
Lobeglitazone (2)
Luseogliflozin Related (3)
Melogliptin (6)
Miglitol Related (2)
Nateglinide (1)
Omarigliptin Related (9)
PEG-Loxenatide (1)
Ranirestat Related (4)
Repaglinide Related (6)
Ruboxistaurin Related (2)
RVX 208 (1)
Saroglitazar Related (2)
Saxagliptin  (35)
Sitagliptin (10)
Teneligliptin Related (3)
Tofogliflozin Related (2)
Trelagliptin Related (7)
Vildagliptin (15)
Blood Products
Anagrelide Related (20)
Apixaban Related (27)
Ataciguat Related (2)
Avatrombopag Related (5)
Azacitidine (8)
Betrixaban Related (8)
Dabigatran Etexilate Related (20)
Disufenton (2)
Edoxaban Related (23)
Fondaparinux Sodium (14)
Fostamatinib Related (6)
Idrabiotaparinux (1)
Lefradafiban (1)
Lusutrombopag Related (12)
Midostaurin (3)
Neu-2000 (1)
Orbofiban Related (1)
Rivaroxaban Related (22)
Rivipansel Related (1)
Ticagrelor (28)
Vorapaxar Related (15)
Cardiovascular Agents
Allisartan Isoproxil  (9)
Atorvastatin Related (8)
Atrasentan Related (1)
Avanafil (24)
Azilsartan Related (21)
Azimilide Related (1)
Bempedoic Acid (6)
Candesartan Related (11)
Cangrelor Related (14)
Choline Fenofibrate (3)
Clevidipine Butyrate (4)
Dalcetrapib Related (4)
Darapladib Related (6)
Dofetilide (2)
Dronedarone Related (14)
Eptifibatide (27)
Evacetrapib Related (3)
Ezetimibe Related (9)
Fimasartan Related (5)
Irbesartan Related (25)
Ivabradine Related (18)
Landiolol  (1)
Lomitapide Related (9)
Olmesartan Medoxomil Related (4)
Omecamtiv mecarbil Related (2)
Osilodrostat phosphate (11)
Pemafibrate Related (6)
Pentisomide (1)
Pitavastatin Related (19)
Ranolazine Related (4)
Rosuvastatin Related (45)
Silodosin (20)
Telmisartan Related (10)
Udenafil  (3)
Vardenafil (5)
Vericiguat (12)
Vernakalant Related (4)
Vorapaxar Related (15)
CNS Agents
Amifampridine Phosphate (7)
Brivaracetam (10)
Cenobamate (1)
Dalfampridine (3)
Deflazacort (1)
Dexmethylphenidate  (5)
Edaravone (2)
Edivoxetine (3)
Eslicarbazepine Acetate Related (8)
Fenfluramine Hydrochloride (4)
Fingolimod Related (15)
Gaboxadol (2)
Laquinimod Related (4)
Levetiracetam Related (13)
Lisdexamfetamine Dimesylate (3)
Perampanel Hydrate (22)
Ponesimod Related (6)
Risdiplam (27)
Siponimod (19)
Stiripentol (3)
Teriflunomide Related (13)
Testosterone Undecanoate (1)
Tetrabenazine (13)
Triheptanoin (2)
Valbenazine Tosylate (4)
Dental and Oral Agents
Gadoteridol (4)
Honokiol Related (6)
Minocycline Hydrochloride (2)
Moxifloxacin Related (15)
Sitafloxacin Related (20)
Dermatological Agents
Benvitimod Related (10)
Brimonidine Tartrate (3)
Ceftaroline Fosamil Acetate (6)
Ceftobiprole Medocaril Sodium (4)
Ciprofloxacin (8)
Contezolid (7)
Crisaborole (7)
Daptomycin Related (15)
Delafloxacin Related (8)
Deoxycholic Acid (6)
Florbetapir (7)
Imatinib Related (18)
Ingenol Mebutate (3)
Irinotecan hydrochloride (12)
Luliconazole Related (6)
Nemonoxacin Malate (20)
Oritavancin Related (1)
Orvepitant (4)
Ponesimod Related (6)
Romidepsin Related (8)
Tavaborole (5)
Tedizolid Related (17)
Telavancin (4)
Tradipitant Related (3)
UR-1505 (1)
Vorinostat Related (8)
Electrolytes
Carglumic Acid (2)
Deferasirox Related (4)
Roxadustat (30)
Sevelamer Carbonate (1)
Tolvaptan Related (19)
Gastrointestinal Agents
Avapritinib (16)
Dexlansoprazole (7)
Eluxadoline (13)
Everolimus (5)
Glycopyrronium Bromide (15)
Ibandronic Acid (2)
Imatinib Related (18)
Irinotecan hydrochloride (12)
Lubiprostone Related (16)
Naldemedine Tosylate (3)
Nalmefene Hydrochloride (1)
Naloxegol Related (5)
Prucalopride Related (24)
Racecadotril Related (2)
Regorafenib Monohydrate (9)
Ripretinib (11)
Rotraxate (1)
Sunitinib Related (19)
TD-8954 (2)
Tenapanor Hydrochloride (8)
Vonoprazan (15)
Zaldaride (3)
Genetic/Enzyme Disorder
Avanafil (24)
Betaine anhydrous (2)
Cholic Acid (2)
Eliglustat Tartrate (8)
Fosdenopterin (3)
Glycerol Phenylbutyrate (4)
Icatibant Related (4)
Idebenone (7)
Migalastat Hydrochloride (8)
Miglustat Related (6)
Nitisinone (3)
Pasireotide Diaspartate (5)
Sodium Phenylbutyrate (2)
Genitourinary Agents
Cefiderocol Sulfate Tosylate (4)
Dutasteride Related (3)
Fesoterodine (16)
Flibanserin Related (7)
Glycerol Phenylbutyrate (4)
Imidafenacin Related (2)
Inaperisone (1)
Mirabegron Related (11)
Ospemifene Related (10)
Plazomicin sulfate (6)
Prasterone (2)
Prulifloxacin Related (7)
Silodosin (20)
Tadalafil Related (11)
Vibegron (11)
Voxelotor (11)
Immunological Agents
Apremilast (16)
Baricitinib Related (13)
Decernotinib Related (3)
Ganirelix Acetate (5)
Icatibant Related (4)
Iguratimod Related (9)
Leniolisib Related (4)
Mycophenolate Mofetil Related (3)
Ozanimod hydrochloride (10)
Tofacitinib Citrate (18)
Metabolic Bone Disease
Doxercalciferol Related (1)
Etelcalcetide Related (2)
Macimorelin Acetate (3)
Maxacalcitol Related (6)
Paricalcitol Related (2)
Risedronic Acid  (2)
Ophthalmic Agents
Alcaftadine Related (1)
Bimatoprost Related (8)
Brinzolamide Related (12)
Emixustat Related (4)
Icoduline (1)
Lifitegrast (13)
Nepafenac Related (1)
Netarsudil (10)
NS-2 (2)
Tafluprost (12)
Travoprost Related (4)
Respiratory Tract
Aclidinium Bromide Related (3)
Ambrisentan Related (6)
Bedaquiline Fumarate (16)
Bosentan Related (14)
Broxaterol (1)
Ciclesonide Related (3)
Delamanid Related (11)
Fluticasone Propionate (1)
Fudosteine Related (1)
Indacaterol Maleate (10)
Ivacaftor Related (27)
Macitentan (13)
Olodaterol Hydrochloride (7)
Pirfenidone Related (3)
Presatovir Related (4)
Revefenacin (9)
Roflumilast Related (22)
Selexipag (12)
Sinapultide (1)
Sitaxentan  (6)
Trantinterol (2)
Treprostinil  (20)
Umeclidinium Bromide Related (6)
Zafirlukast Related (4)
Skeletal Muscle Relaxants
Cisatracurium Besylate Related (1)
Eldecalcitol (17)
Ibandronate Related (13)
Sleep Disorder Agents
Almorexant Related (2)
Eszopiclone (4)
Indiplon Related (6)
JNJ-42847922 (3)
Lemborexant Related (8)
Pitolisant Related (4)
R-228060 (4)
Ramelteon (9)
Solriamfetol (1)
Suvorexant (23)
Tasimelteon Related (17)
Life Science
Inhibitors/Agonists
ADC (371)
ADC Linker (371)
AMPK Signaling Pathway (2308)
ACC (32)AMPK (208)ATPase (146)CaMK (94)Dynamin (24)Epigenetic Reader Domain (556)FOXO (13)Gli (8)GLUT (54)HDAC (445)HMGCR (69)Lipase (142)mTOR (325)Orai1 (2)PDE (567)PFKFB3 (7)PI3K (580)PIKfyve (17)PKA (149)SREBP (6)TFEB (1)ULK (24)YAP (51)
Angiogenesis (2326)
ALK (117)Bcr-Abl (121)BTK (190)EGFR (558)FAK (73)FGFR (192)FLT3 (173)HER2 (44)HIF (191)JAK (357)PDGFR (176)Src (201)Syk (64)VDA (3)VEGFR (402)
Anti-Infection (7584)
3CLpro (49)Antibacterial (3579)Antifungal (963)Antiparasitic (786)Antiprotozoal (7)Antiviral (224)Arenavirus (7)BVDV (3)CMV (57)Dengue Virus (63)EBV (22)Enterovirus (59)FCoV (3)Filovirus (33)Flavivirus (101)GraR (1)HBV (218)HCV (276)HCV Protease (237)HHV (1)HIV (692)HIV Integrase (55)HIV Protease (638)HPV (22)HRV (3)HSV (176)Influenza Virus (400)LpxC (2)M2 proton channel (2)MERS-CoV (1)Neuraminidase (11)NNRTI (17)NRTI (26)Orthopoxvirus (60)Parasite (946)Penicillin-Binding Protein (21)Peroxiredoxin (1)PLP (15)Prion (11)Protein Synthesis (6)RABV (5)Reverse Transcriptase (159)RSV (61)SAMHD1 (1)SARS-CoV (494)SQLE (6)TMV (13)Viral MTase (2)Virus Protease (324)VSV (11)β-lactamase (105)
Antibody-Drug Conjugate/ADC Related (744)
ADC Linker (371)ADC Toxins (205)Payload-Linker Conjugate (184)
Apelin signaling pathway (1591)
Akt (514)AMPK (208)Apelin Receptor (23)cAMP (66)MLCK (11)NOS (450)Phospholipase (180)PI3K (580)PKA (149)PKC (260)β-arrestin (33)
Apoptosis (3478)
Apoptosis (2055)Apoptosis Inducer (1362)Bcl-2 (234)Bcl-6 (16)BRK (6)c-Myc (87)c-RET (82)C/EBP (2)Caspase (465)DAPK (18)Ferroptosis (249)FKBP (37)GDNF Receptor (4)IAP (71)IDO (86)MDM2 (217)MRCK (2)Necroptosis (65)p32 (1)p53 (126)Paraptosis (5)PERK (114)PKD (18)Pyroptosis (36)RIP Kinase (109)Survivin (33)Thymidylate Synthase (52)TNF (401)TNF Receptor (336)TNF-alpha (80)
Autophagy (1107)
ATG4B (4)ATTECs (6)AUTACs (11)Autophagy (999)Beclin1 (2)FKBP (37)LC3 (28)LRRK2 (43)Lysosome (1)mitoNEET (1)Mitophagy (78)PPT (1)SPHK (41)TFEB (1)ULK (24)
Calcium Signaling Pathway (1387)
AChR (603)ATPase (146)Calcineurin (9)Calcium Channel (555)CaMK (94)CRAC Channel (17)Na+/Ca2+ Exchanger (19)Orai1 (2)Phospholipase (180)PKC (260)TRP Channel (259)
cAMP Signaling Pathway (761)
Adenylyl Cyclase (1)cAMP (66)CD73 (30)CREB (6)Epac (9)GSK-3 (219)HCN Channel (17)PDE (567)PKA (149)
Cell Cycle (6661)
Antifolate (78)APC (12)Aurora Kinase (129)BUB (3)Casein Kinase (160)Cdc25 (2)CDK (689)Chk (78)CRISPR/Cas9 (17)CRM1 (19)DHFR (90)DNA polymerase θ (2)DNA/RNA Synthesis (1337)DOCK (6)DYRK (79)E2F (3)eIF (71)Endonuclease (7)FOXM1 (3)G-quadruplex (23)Haspin Kinase (14)HDAC (445)HGF (1)HSF (5)HSP (242)IRE1 (39)Kinesin (77)Lats kinase (3)LIMK (27)Mad2 (1)Microtubule/Tubulin (438)MKLP (2)Mps1 (27)MTH2 (1)Nucleoside Antimetabolite/Analog (1696)p21 (5)PAK (40)PDI (6)PKMYT1 (2)PLK (67)PPAR (418)PTEN (18)RAD51 (27)Rho (49)RNA polymerase 2 (1)RNA polymerase 1 (2)ROCK (124)Separase (1)Sirtuin (176)SRPK (49)STK33 (3)TACC (3)Telomerase (30)TOPK (11)Topoisomerase (456)Wee1 (20)YB-1 (5)
Cytoskeleton Signaling Pathway (1058)
Actin (6)Arp2/3 Complex (14)CYTH (1)Cytoplasmic dynein (1)Dynamin (24)FAK (73)Filamin-A (1)Gap Junction (17)Gap Junction Protein (14)Integrin (222)Kinesin (77)MARK (5)Microtubule/Tubulin (438)MLCK (11)Mps1 (27)Myosin (37)PAK (40)ROCK (124)Spastin (1)
DNA Damage Response (DDR) Pathway (4391)
ADAR (1)AP endonuclease (4)ATAD5 (1)ATM/ATR (92)Aurora Kinase (129)Casein Kinase (160)ClpP (11)CRISPR/Cas9 (17)DNA Alkylator/Crosslinker (139)DNA Stain (2)DNA-PK (66)DNA/RNA Synthesis (1337)HDR (1)HSP (242)MRE11 (1)MTH1 (10)Nucleoside Antimetabolite/Analog (1696)OGG (3)p97 (22)PARP (261)RAD51 (27)RAD52 (2)REV1 (1)Telomerase (30)Topoisomerase (456)WRN (6)YB-1 (5)
Endocrinology/Hormones (1453)
5 Alpha Reductase (16)ACE (120)Adrenergic Receptor (383)Androgen Receptor (165)Aromatase (21)ERR (330)GHSR (29)Glucocorticoid Receptor (73)GNRH Receptor (28)Growth Hormone (1)Mineralocorticoid Receptor (13)Opioid Receptor (116)Progesterone Receptor (23)PTHR (7)Renin (28)Sepiapterin reductase (2)SSTR (45)Taste receptor (22)Thyroid Hormone Receptor (66)TPO (4)TRHR (2)TSH Receptor (20)TTR (11)
Endoplasmic Reticulum Stress (1416)
ASK (2)IRE1 (39)JNK (224)PDI (6)PERK (114)ROS (1081)
Epigenetics (3369)
AMPK (208)Aurora Kinase (129)DNA Methyltransferase (69)Epigenetic Reader Domain (556)FTO (23)HDAC (445)HIF (191)Histone Acetyltransferase (135)Histone Demethylase (191)Histone Methyltransferase (402)JAK (357)MBD-containing protein (1)METTL3 (17)MicroRNA (41)PAD (33)PARP (261)Pim (83)PKC (260)PRMT (16)SF3B1 (7)Sirtuin (176)TET (12)TET Protein (5)
ERBB signaling pathway (4243)
Akt (514)c-Myc (87)Caspase (465)CDK (689)CREB (6)DNA-PK (66)ERK (445)ERR (330)FOXO (13)GSK-3 (219)HER2 (44)JAK (357)JNK (224)MDM2 (217)MEK (156)mTOR (325)NF-κB (882)PAK (40)PI3K (580)PKC (260)PTEN (18)Raf (150)Ras (410)Rho (49)Src (201)STAT (327)TEAD (10)YAP (51)
Ferroptosis Signaling Pathway (175)
ABC Transporter (23)ACC (32)GPx (77)GTPCH (1)SCD (31)SLC (7)VDAC (6)
FOXO Signaling Pathway (2639)
Akt (514)AMPK (208)CRM1 (19)EGFR (558)ERK (445)FOXO (13)Insulin Receptor (59)JNK (224)MDM2 (217)MEK (156)PDK-1 (26)PI3K (580)Ras (410)SOS (17)STAT (327)TGF-beta/Smad (375)TGF-β Receptor (26)β-catenin (134)
GPCR/G Protein Pathway (5312)
5-HT Receptor (576)Adenosine Receptor (264)Adenylate Cyclase (36)Adenylyl Cyclase (1)Adiponectin Receptor (6)Adrenergic Receptor (383)Amylin receptor (1)Angiotensin Receptor (115)Apelin Receptor (23)Bombesin Receptor (12)Bradykinin Receptor (22)cAMP (66)Cannabinoid Receptor (103)CaSR (26)CCR (125)CGRP Receptor (21)Chemerin Receptor (6)Cholecystokinin Receptor (81)CRF Receptor (32)CXCR (147)Dopamine Receptor (293)Endothelin Receptor (63)Epac (9)Free Fatty Acid Receptor (81)G protein (3)G protein-coupled Bile Acid Receptor 1 (24)GHSR (29)GLP Receptor (42)Glucagon Receptor (92)GNRH Receptor (28)GPCR (319)GPCR19 (2)GPR109A (1)GPR119 (24)GPR139 (6)GPR171 (2)GPR183 (3)GPR24 (18)GPR35 (17)GPR40 (7)GPR52 (6)GPR55 (6)GPR6 (4)GPR68 (2)GPR84 (13)GPR88 (10)Guanylate Cyclase (40)HCAR (12)Histamine Receptor (354)ICMT (61)Kisspeptin Receptor (2)LHCGR (40)LPA Receptor (30)LPL Receptor (169)Mas-related G-protein-coupled Receptor (MRGPR) (24)Melanocortin Receptor (43)mGluR (285)Motilin Receptor (4)MRGPR (13)Neuropeptide Y receptor (38)Neurotensin Receptor (21)NMUR (3)NPFF receptor (4)Opioid Receptor (116)OXTR (20)P2Y Receptor (122)PACAP Receptor (4)PAFR (89)PAR (62)Prostaglandin Receptor (506)Ras (410)RGS (6)RXFP Receptor (15)S1P Receptor (6)Sigma Receptor (68)SOS (17)SRPK (49)SSTR (45)SUCNR1 (6)TAAR (12)TSH Receptor (20)Urotensin Receptor (9)Vasopressin Receptor (37)β-arrestin (33)
Hedgehog (Hh) (1297)
BMI-1 (10)c-Myc (87)Casein Kinase (160)CDK (689)Cytoplasmic dynein (1)Gli (8)GSK-3 (219)PKA (149)Smo (47)ULK (24)
HIF-1 Signaling Pathway (2750)
Akt (514)Bcl-2 (234)CaMK (94)E1/E2/E3 Enzyme (210)eIF (71)ERK (445)GLUT (54)HIF (191)IFNAR (60)IL Receptor (197)MEK (156)MNK (16)mTOR (325)NOS (450)p21 (5)PAI-1 (47)PDK-1 (26)Phospholipase (180)PI3K (580)PKC (260)Tie-2 (29)TLR (260)VEGF (2)
Hippo (105)
Lats kinase (3)MAP4K (48)MST (6)TEAD (10)YAP (51)
Immunology/Inflammation (4843)
AIM2 (6)AP-1 (40)Arginase (28)Calcineurin (9)CCR (125)CD19 (3)CD2 (1)CD20 (10)CD22 (4)CD276/B7-H3 (5)CD28 (12)CD28-B7 (1)CD3 (6)CD38 (14)CD47 (12)CD6 (1)CD73 (30)CD74 (3)CD80 (1)cGAS (20)Complement C3 (1)COX (643)CRTH2 (9)CTLA-4 (6)CXCR (147)Cyclophilin (6)CYPA (2)FAP (24)FKBP (37)FLAP (24)FPR (24)Galectin (17)Glucocorticoid Receptor (73)Glycoprotein VI (7)GM-CSF (4)Histamine Receptor (354)HMGB (1)IFNAR (60)IKZF_Family (2)IL (157)IL Receptor (197)Immunology & Inflammation Related (404)IRAK (84)IRF3 (1)LAG-3 (7)LanC-like protein (1)Legumain (3)Leukotriene C4 Synthase (1)LTA4H (3)LTR (160)MALT1 (28)Mast Cell (2)Mesothelin (2)MIF (22)Mucin (12)MyD88 (23)NADPH Oxidase (56)NFAT (25)NLR (142)NO Synthesis (6)NOS (450)NOT (4)Nrf2 (218)PD-1/PD-L1 (156)PG Synthase (61)PSMA (27)Pyroptosis (36)ROS (1081)Ros1 (48)S100A9 (1)Scavenger receptor (6)SIK (18)SOD (58)SPHK (41)STING (129)TENT (1)Thrombopoietin Receptor (14)Tim3 (8)TLR (260)TRAF (1)TSPO (5)VISTA (4)XBP1 (1)
Insulin Receptor/IGF-1 Receptor Signaling (2024)
Akt (514)Bcl-2 (234)CREB (6)ERK (445)FOXO (13)GLUT (54)GSK-3 (219)IGF-1R (101)Insulin Receptor (59)MEK (156)mTOR (325)PI3K (580)PKM2 (8)PTEN (18)Raf (150)Ras (410)RSK (41)SOS (17)
JAK-STAT-Signaling Pathway (1233)
EGFR (558)JAK (357)Pim (83)STAT (327)
MAPK/ERK Pathway (1460)
AP-1 (40)ERK (445)HPK1 (52)JNK (224)KLF (7)MAP3K (42)MAP3K12 (1)MAP4K (48)MAP4K4 (7)MAP4K6 (1)MEK (156)MK2 (19)MLK (30)MNK (16)p38 MAPK (452)Raf (150)Ras (410)RSK (41)TAOK (1)
Membrane Transporter/Ion Channel (2774)
ABC Transporter (23)AKK1 (3)ANT (1)AQP (14)AQP3 (1)ARF (6)ATP synthase (33)ATPase (146)BCRP (39)Calcium Channel (555)Calmodulin (23)CFTR (81)Chloride Channel (65)CRAC Channel (17)CRM1 (19)EAAT (6)Efflux pump (4)ENT (3)Ferroportin (10)GABA Receptor (313)GLUT (54)Glutamate transporter (35)Glycine transporter (24)HCN Channel (17)IBAT (10)ITPKA (2)MAT (44)MCT (26)Na+/Ca2+ Exchanger (19)Na+/K+ ATPase (38)Na/HCO3 cotransporter (1)NKCC (7)Oct (14)OCTN (1)Orai1 (2)Organic Anion Transporter (4)P-gp (130)P2X Receptor (99)Piezo (4)Potassium Channel (495)Proton Pump (95)SEO1 (1)SGLT (55)SLC (7)SLC6A19 (1)Sodium Channel (334)SV2 (5)TRP Channel (259)UCP (2)URAT1 (21)Urea Transporter (7)VDAC (6)VRAC (2)
Metabolic Enzyme (5882)
11β-HSD (40)15-PGDH (4)2OG Oxygenase (1)3-PGDH (1)3MST (2)6PGD (3)ACAT (131)ACC (32)ACMSD (2)Aconitate hydratase (2)ACS (6)Adenosine Deaminase (25)Adenosylhomocysteinase (12)ADP-ribosyltransferase (1)AhR (87)AKR (18)ALDH (55)Aldose Reductase (87)Aminopeptidase (70)Antifolate (78)AO (3)APOA (1)ApoE (2)Arginase (28)Asparagine synthetase (1)ATF/CREB proteins (2)ATP Citrate Lyase (8)ATP synthase (33)BDK (1)Beta-glucuronidase (27)Carbonic Anhydrase (185)Carboxylesterase (46)Carboxypeptidase (23)Cathepsin (147)Ceramidase (23)CETP (20)Cholesterol Transporter (2)CPA (7)CPSI (4)Creatine kinase (1)Cryptochrome (7)CSE (4)CYP51 (5)D-amino acid oxidase (3)D6D (1)Decarboxylase (15)Dehydrogenase (385)DGAT (66)DGK (19)DMT1 (1)Dopamine β-hydroxylase (9)E-NTPDase (15)Elastase (48)Enolase (7)Enteropeptidase (7)ERAP (4)FABP (13)Factor Xa (77)Farnesyl Transferase (47)FAS (72)FBPase (6)Ferroptosis (249)FOXO (13)FPR (24)FTO (23)Fumarate hydratase (3)FVII (4)FXR (107)G0/G1 switch protein 2 (2)GABA Transaminase (2)Galactosidases (6)GCN (3)GCS (7)GGTase (7)Glucokinase (62)Glucosidase (172)GLUT (54)Glutaminase C (2)Glutathione Reductase (6)Glyoxalase (15)GOAT (1)GPx (77)GSNOR (3)GST (38)Heme Oxygenase (HO) (5)Hexokinase (11)HMGCR (69)HPSE (4)Hydrolase (14)Hydroxylase (41)IDH (48)IDO (86)Ketohexokinase (7)LDL (29)LDLR (23)Lipase (142)Lipoxygenase (212)LOX (8)LRH-1 (5)LXR (41)MAGL (43)MASTL (4)MDH (3)MetAP (23)MGAT (7)Mineralocorticoid Receptor (13)Mitochondrial Electron Transport Chain (4)Mitochondrial Metabolism (214)MPC (5)NAMPT (39)Neprilysin (35)NNMT (12)NPP (2)NPR (15)NQO (3)OGT (12)OPA1 (1)P448 (1)P450 (526)PAI-1 (47)PARG (13)PDE (567)PDHK (19)PEPCK (5)PGAM1 (2)PGC-1α (12)PHGDH (6)Phospholipase (180)Phosphorylase (28)PI5P4K (14)PKM1 (3)PKM2 (8)Procollagen C Proteinase (2)Proprotein convertases (7)Pyruvate Kinase (39)QR (29)RAR/RXR (132)RBP (5)REV-ERB (12)ROR (92)SCD (31)sEH (54)SGK (19)SHMT (8)Sialyltransferase (4)Sphingosine acyltransferase (1)SQOR (2)Steroid Sulfatase (13)TDO (3)TGH (1)Thioredoxin (24)Thrombin (110)Thymidylate Synthase (52)Transferase (272)Transketolase (10)TrxR (18)Trypanothione reductase (1)UGT (15)VD/VDR (63)Xanthine Oxidase (85)αKGD (2)
MTOR Signaling Pathway (2807)
Akt (514)AMPK (208)ATM/ATR (92)EGFR (558)ERK (445)GSK-3 (219)IKK (101)Insulin Receptor (59)MEK (156)mTOR (325)p53 (126)PDK-1 (26)PI3K (580)Raf (150)Ras (410)RSK (41)SLC (7)TNF (401)Wnt (206)
Necroptosis signaling pathway (772)
Caspase (465)MLKL (5)Necroptosis (65)RIP Kinase (109)TNF Receptor (336)TNF-alpha (80)
Neuronal Signaling (6031)
5-HT Receptor (576)AAK1 (21)AChE (61)AChR (603)Adenosine Kinase (9)Adrenergic Receptor (383)AMPAR (57)Amylin receptor (1)Amyloid-β (308)Calcium Channel (555)CaMK (94)Cannabinoid Receptor (103)CGRP Receptor (21)Cholecystokinin Receptor (81)Cholinesterase (393)CHT (1)COMT (25)DAT (36)Dopamine Receptor (293)Endorphin (1)Enkephalinase (5)FAAH (72)GABA Receptor (313)Glucosylceramide Synthase (21)GluR (582)GPR119 (24)GPR139 (6)GPR24 (18)GPR55 (6)Histamine Receptor (354)Huntingtin (10)Imidazoline Receptor (25)Kainate receptor (5)MAO (308)Melanocortin Receptor (43)mGluR (285)MT Receptor (18)NET (6)Neuropeptide Y receptor (38)Neurotensin Receptor (21)NGF (3)NK Receptor (99)NMDA (1)NMDAR (126)Notch (46)Nurr1 (10)OLIG2 (2)Opioid Receptor (116)OX Receptor (50)P2X Receptor (99)Proprotein convertases (7)PSD-95 (2)QC (7)RAGE (6)REST (1)Ryanodine Receptor-1 (1)S100β (4)Secretase (196)SERT (65)Sigma Receptor (68)SMS (5)SSRIs (5)Substance P (3)TAAR (12)Tau Protein (57)Trk Receptor (109)TRP Channel (259)TTR (11)α-synuclein (36)
NF-κB Signaling Pathway (1144)
IKK (101)MALT1 (28)NF-κB (882)Nrf2 (218)Pirin (4)RANKL (12)RANKL/RANK (12)RIP Kinase (109)TAK1 (4)
Notch Signaling Pathway (1219)
ERK (445)Gli (8)MRCK (2)Notch (46)p53 (126)ROCK (124)TGF-beta/Smad (375)β-catenin (134)
p53 Signaling Pathway (1183)
AMPK (208)ATM/ATR (92)Bcl-2 (234)Caspase (465)Chk (78)MDM2 (217)mTOR (325)p21 (5)p53 (126)
Phospholipase D signaling pathway (2606)
APC (12)EGFR (558)Frizzled (2)GPCR (319)GSK-3 (219)HIF (191)IL Receptor (197)mTOR (325)NF-κB (882)Phospholipase (180)Raf (150)Ras (410)SOS (17)Wnt (206)β-catenin (134)
PI3K/AKT/mTOR Pathway (1727)
Akt (514)AMPK (208)ATM/ATR (92)DNA-PK (66)FOXO (13)GSK-3 (219)MELK (10)mTOR (325)PDK (38)PDK-1 (26)PI3K (580)PI4K (39)PIKfyve (17)PIN1 (17)PTEN (18)RSK (41)
PPAR Signaling Pathway (4037)
ACS (6)Akt (514)AMPK (208)APOA (1)AQP (14)Bcl-6 (16)FABP (13)FATP (4)IL (157)LXR (41)MMP (305)NF-κB (882)NLR (142)OxPhos (47)PDK-1 (26)PEPCK (5)PGC-1α (12)PPAR (418)RAR/RXR (132)RGS (6)ROS (1081)SCD (31)SGK (19)Sirtuin (176)STAT (327)TNF-alpha (80)
Protease (1165)
ADAMTS (7)Aspartic Protease (2)Cysteine Protease (129)Dipeptidase 1 (4)DP-IV (1)DPP (32)DPP2 (2)DPP4 (68)Glutaminase (47)MMP (305)NEP (6)PE (2)Proteasome (231)Ser/Thr Protease (245)Serine Protease (5)SPP (1)Tyrosinase (203)
Protein Tyrosine Kinase/RTK (3445)
Ack1 (6)ALK (117)Bcr-Abl (121)BMX Kinase (5)BRK (6)BTK (190)c-FMS (97)c-Kit (143)c-Met/HGFR (173)c-RET (82)DDR1/DDR2 Receptor (25)DYRK (79)EGFR (558)Ephrin Receptor (25)ErbB (9)FAK (73)FGF (3)FGFR (192)FLT3 (173)GAK (627)HER2 (44)IGF-1R (101)Insulin Receptor (59)ITK (18)JAK (357)MRCK (2)PDGFR (176)PTK (9)Pyk2 (16)Ros1 (48)SHP2 (64)Src (201)Syk (64)TAM Receptor (71)Tie-2 (29)Trk Receptor (109)VEGF (2)VEGFR (402)
Pyroptosis (1790)
Caspase (465)Cathepsin (147)IL (157)MyD88 (23)NF-κB (882)TLR (260)
RAS signaling pathway (3378)
Akt (514)c-Myc (87)CDK (689)EGFR (558)ERK (445)MEK (156)mTOR (325)NF-κB (882)PAK (40)PDK (38)PI3K (580)PKC (260)PKD (18)Raf (150)Ras (410)RasGAP (2)SHP2 (64)YAP (51)
Stem Cells (2366)
BMI-1 (10)Casein Kinase (160)CREB (6)DKK1 (1)ERK (445)Frizzled (2)Gli (8)GSK-3 (219)Hedgehog (52)JAK (357)LIN28 (4)MST (6)Notch (46)Notum (2)PKA (149)PORCN (13)ROCK (124)sFRP-1 (2)Smo (47)SOD1 (3)STAT (327)TGF-beta/Smad (375)Wnt (206)YAP (51)β-catenin (134)
TGF-beta/Smad (647)
Bcr-Abl (121)PKC (260)ROCK (124)TGF-beta/Smad (375)TGF-β Receptor (26)
Toll-like Receptor (TLR) Pathway (1023)
CREB (6)IKK (101)IRAK (84)IRF3 (1)JNK (224)MyD88 (23)p38 MAPK (452)TAK1 (4)TLR (260)
Ubiquitin (574)
DUB (106)E1/E2/E3 Enzyme (210)FBXO (3)NAE (9)p97 (22)Proteasome (231)SUMO (10)USP30 (1)
VEGF signaling pathway (2044)
Akt (514)ERK (445)FAK (73)JNK (224)NOS (450)p38 MAPK (452)PAK (40)PKC (260)SHP2 (64)Src (201)VEGFR (402)
Vitamin D Related/Nuclear Receptor (1060)
Androgen Receptor (165)Glucocorticoid Receptor (73)LXR (41)Mineralocorticoid Receptor (13)PPAR (418)Progesterone Receptor (23)RAR/RXR (132)REV-ERB (12)ROR (92)Thyroid Hormone Receptor (66)VD/VDR (63)
Wnt Signaling Pathway (3894)
AP-1 (40)APC (12)ATF/CREB proteins (2)c-Myc (87)Calcineurin (9)CaMK (94)Casein Kinase (160)CDK (689)CREB (6)Frizzled (2)GSK-3 (219)JNK (224)MMP (305)NF-κB (882)NFAT (25)p300/CBP/PROTAC (2)PDE (567)Phospholipase (180)PKC (260)PKG (26)Rho (49)ROCK (124)ROR (92)Wnt (206)β-catenin (134)
Other Inhibitors/Agonists (6822)
20-HETE (2)AIMP2-DX2 (3)Amino Acids and Amino Acid Derivatives (112)Aminoacyl-tRNA Synthetase (32)Analgetic (38)Anesthetic (25)Anti-inflammation (32)Anti-Thyroid Agent (1)Anti-tumor (7)Anti-ulcer (17)Anticoagulant (3)Antispasmodic Agent (10)ASGPR (10)Bcat (12)c-RET (82)Cancer Stem Cells (2)CAR (9)Cardiac transcription factor (2)CBFβ-SMMHC (1)CD20 (10)CD73 (30)CerK (1)CHC (1)Chelating Agent (46)Choleretic (2)Choline Kinase (9)CNT (1)CRTH2 (9)CSE (4)CSN5/Jab1 (1)DcpS (1)Decarboxylase (15)Dehydrogenase (385)Diabetes (16)Diuretic (15)Drug Metabolite (597)DUE-B (1)E2F (3)ECE (2)ELOVL6 (1)Endogenous Metabolite (3311)ERO1 (5)Factor VIII (1)FAP (24)FATP (4)Fer/FerT (2)FPP synthase (1)Fucosyltransferase (4)Fungicide (64)G protein (3)Galectin (17)Galectin-3 (11)GBF1 (1)GCase (8)Glucocorticoid Receptor (73)GRK (31)GTPCH (1)Herbicide (56)HIPK2 (3)Histidine kinase (6)HMG-CoA (1)HNF4α (2)HPPD (5)HRGP (1)Hydroxylase (41)IMP1 (1)Importin β (2)Insecticide (71)ITPKA (2)LAT1 (5)LDL (29)Lipase (142)Lipocalin-2 (1)LYTACs (11)MALAT1 (2)MITF (3)MLKL (5)Molecular Glues (104)MPO (8)MTTP (13)Muscle Relaxant (12)MYOF (3)Neuroprotection/neurogenic Agent (4)NMD (1)NT (6)Nur77 (11)O-GlcNAcase (17)OPN4 (1)OSBP (2)OSBPL (1)OSC (2)Osteoclasts/Bone/Osteogenesis (22)OxPhos (47)PAM complex (1)PANK (5)PAX2 (1)PBR (4)PC-TP (1)PCA1 (1)PCSK9 (39)PDX1 (1)PEPT (1)PFKFB3 (7)Phosphatase (428)Phosphorylase (28)Photosensitizer (43)PIN1 (17)PKG (26)Platelet (46)PME-1 (2)PMO/MNA (4)PNP (1)PREP (36)Protein Synthesis (6)PXR (9)Quorum Sensing (60)RasGAP (2)Rev-ErbA (3)RPE65 (3)RUNX (12)SAP (1)SARM1 NADase (1)SMARC (9)SQS (7)SREBP (6)SRPK (49)Sweetener (5)Tgase (7)Thioredoxin (24)TIR1 (4)TNIK (8)TNK (5)TNNI3K (2)UGT1A1 (2)Urease (11)vanin (4)VDA (3)Vitamin (141)VPS (6)XOR (1)α-amylase (18)Others (2691)
Inhibitory Monoclonal Antibody
Human Inhibitory Monoclonal Antibody (549)
ADAM9/monoclonal antibody (1)Adrenomedullin/monoclonal antibody (1)ALK/monoclonal antibody (1)AMHRII/monoclonal antibody (1)Amyloid Alpha/monoclonal antibody (1)Amyloid-β/monoclonal antibody (6)Ang2/monoclonal antibody (1)ANGPTL3/monoclonal antibody (1)Antifolate/monoclonal antibody (1)APRIL/monoclonal antibody (1)ASCT2/monoclonal antibody (1)AXL/monoclonal antibody (2)B7-H4/monoclonal antibody (1)BST2/monoclonal antibody (1)BTLA/monoclonal antibody (1)BTN1A1/monoclonal antibody (1)c-FMS/monoclonal antibody (6)c-Kit/monoclonal antibody (1)c-Met/HGFR/monoclonal antibody (3)C1q/monoclonal antibody (1)C1s/monoclonal antibody (1)C5AR/monoclonal antibody (1)CA Ⅸ/monoclonal antibody (1)CA-125/monoclonal antibody (1)CCL2/monoclonal antibody (1)CCL20/monoclonal antibody (1)CCL5/monoclonal antibody (1)CCR/monoclonal antibody (3)CD105/monoclonal antibody (1)CD11/monoclonal antibody (2)CD123/monoclonal antibody (2)CD137/monoclonal antibody (1)CD138/monoclonal antibody (1)CD14/monoclonal antibody (1)CD163/monoclonal antibody (1)CD166/monoclonal antibody (1)CD19/monoclonal antibody (5)CD2/monoclonal antibody (1)CD20/monoclonal antibody (7)CD22/monoclonal antibody (3)CD23/monoclonal antibody (1)CD248/monoclonal antibody (1)CD25/monoclonal antibody (3)CD276/B7-H3/monoclonal antibody (4)CD27L/monoclonal antibody (1)CD28/monoclonal antibody (3)CD3/monoclonal antibody (3)CD33/monoclonal antibody (2)CD37/monoclonal antibody (3)CD38/monoclonal antibody (3)CD39/monoclonal antibody (1)CD4/monoclonal antibody (5)CD40/monoclonal antibody (8)CD40L/monoclonal antibody (4)CD44v6/monoclonal antibody (1)CD45/monoclonal antibody (1)CD46/monoclonal antibody (1)CD47/monoclonal antibody (5)CD52/monoclonal antibody (2)CD56/monoclonal antibody (1)CD6/monoclonal antibody (1)CD62p/monoclonal antibody (2)CD7/monoclonal antibody (1)CD70/monoclonal antibody (1)CD73/monoclonal antibody (2)CD74/monoclonal antibody (1)CD79b/monoclonal antibody (2)CD80/monoclonal antibody (1)CD98/monoclonal antibody (2)CDH6/monoclonal antibody (1)Cdiff Toxin A/monoclonal antibody (1)CEA/monoclonal antibody (1)CEACAM1/monoclonal antibody (1)CEACAM5 /monoclonal antibody (1)CEACAM6/monoclonal antibody (1)CGRP Receptor/monoclonal antibody (4)CLDN18.2/monoclonal antibody (1)CLDN6/monoclonal antibody (2)CLEC4C/monoclonal antibody (1)clusterin/monoclonal antibody (1)Complement C3/monoclonal antibody (1)Complement System/monoclonal antibody (8)CTGF/monoclonal antibody (1)CTLA-4/monoclonal antibody (5)CX3CL1/monoclonal antibody (1)CXCL10/monoclonal antibody (1)CXCR/monoclonal antibody (2)DKK1/monoclonal antibody (2)DLL3/monoclonal antibody (1)DLL4/monoclonal antibody (1)DPEP3/monoclonal antibody (1)DPP4/monoclonal antibody (1)EGFR/monoclonal antibody (9)EpCAM/monoclonal antibody (2)EphA3/monoclonal antibody (1)ErbB/monoclonal antibody (4)Factor XI/monoclonal antibody (2)Factor XII/monoclonal antibody (1)FAP/monoclonal antibody (1)FcRn/monoclonal antibody (3)FGF23/monoclonal antibody (1)FGFR/monoclonal antibody (4)Filovirus/monoclonal antibody (7)FLT3/monoclonal antibody (1)FRα/monoclonal antibody (1)FZD/monoclonal antibody (1)FZD10/monoclonal antibody (1)GCGR/monoclonal antibody (2)GD2/monoclonal antibody (2)GD3/monoclonal antibody (1)GDF-15/monoclonal antibody (2)GFRA3/monoclonal antibody (1)GFRAL/monoclonal antibody (1)glycoprotein (GP) IIb/IIIa/monoclonal antibody (1)Glycoprotein VI/monoclonal antibody (1)GM-CSF/monoclonal antibody (3)GPA33/monoclonal antibody (1)GPC3/monoclonal antibody (1)GPNMB/monoclonal antibody (1)GPRC5D/monoclonal antibody (1)Gremlin-1/monoclonal antibody (1)GUCY2C/monoclonal antibody (1)HBEGF/monoclonal antibody (1)Hepcidin/monoclonal antibody (1)HER2/monoclonal antibody (5)HFE2/monoclonal antibody (1)HGF/monoclonal antibody (2)Histone H1/monoclonal antibody (1)HTRA1/monoclonal antibody (1)ICAM-1/monoclonal antibody (1)ICOS/monoclonal antibody (4)ICOSL/monoclonal antibody (1)IFNAR/monoclonal antibody (5)IgE/monoclonal antibody (3)IGF-1R/monoclonal antibody (5)IL-12/monoclonal antibody (1)IL-13/monoclonal antibody (5)IL-13Ra1/monoclonal antibody (1)IL-15/monoclonal antibody (1)IL-17a/monoclonal antibody (5)IL-17c/monoclonal antibody (1)IL-17R/monoclonal antibody (1)IL-18/monoclonal antibody (1)IL-1a/monoclonal antibody (1)IL-1R1/monoclonal antibody (1)IL-1RL1/monoclonal antibody (2)IL-1β/monoclonal antibody (2)IL-20/monoclonal antibody (1)IL-21/monoclonal antibody (1)IL-22/monoclonal antibody (1)IL-22Ra/monoclonal antibody (1)IL-23/monoclonal antibody (5)IL-31Ra/monoclonal antibody (1)IL-33/monoclonal antibody (2)IL-36R/monoclonal antibody (1)IL-3Rβ/monoclonal antibody (1)IL-4/monoclonal antibody (1)IL-4Ra/monoclonal antibody (3)IL-5/monoclonal antibody (2)IL-5Rα/monoclonal antibody (1)IL-6/monoclonal antibody (7)IL-6R/monoclonal antibody (1)IL-6Ra/monoclonal antibody (1)IL-7Ra/monoclonal antibody (1)IL-8/monoclonal antibody (1)IL-9/monoclonal antibody (1)IL1RAP/monoclonal antibody (1)IL22RA1 /monoclonal antibody (1)ILDR2/monoclonal antibody (1)ILT7/monoclonal antibody (1)Influenza Virus/monoclonal antibody (1)Integrin/monoclonal antibody (9)KIR/monoclonal antibody (1)KIR3DL2 /monoclonal antibody (1)Klotho β/monoclonal antibody (1)L-selectin/monoclonal antibody (1)LAG-3/monoclonal antibody (3)LDLR/monoclonal antibody (1)LEPR/monoclonal antibody (1)LIF/monoclonal antibody (1)LILRB2/monoclonal antibody (1)LINGO-1/monoclonal antibody (1)LIV-1/monoclonal antibody (1)LOXL2/monoclonal antibody (1)LRRC15/monoclonal antibody (1)LT α/monoclonal antibody (1)LYPD3/monoclonal antibody (1)MAdCAM-1/monoclonal antibody (1)MASP-2/monoclonal antibody (1)MCAM/monoclonal antibody (1)Mesothelin/monoclonal antibody (2)MIF/monoclonal antibody (1)MMP/monoclonal antibody (1)MUC16/monoclonal antibody (1)MUC5AC/monoclonal antibody (1)Mucin/monoclonal antibody (2)NaPi2b /monoclonal antibody (2)Nectin-4/monoclonal antibody (1)NeuGcGM3/monoclonal antibody (1)Neuropilin-1/monoclonal antibody (1)Neurotensin Receptor/monoclonal antibody (1)NGF/monoclonal antibody (4)NKG2A/monoclonal antibody (1)NKG2D /monoclonal antibody (1)Notch/monoclonal antibody (1)NOTCH3/monoclonal antibody (1)OSMR/monoclonal antibody (1)Osteopontin/monoclonal antibody (1)OX40/monoclonal antibody (5)OX40L /monoclonal antibody (2)P-cadherin/monoclonal antibody (1)PAC1/monoclonal antibody (1)PAR/monoclonal antibody (1)PCSK9/monoclonal antibody (4)PD-1/PD-L1/monoclonal antibody (31)PDGFR/monoclonal antibody (3)Phosphatidylserine/monoclonal antibody (1)Phosphorylcholine/monoclonal antibody (1)PRLR/monoclonal antibody (1)Prolactin Receptor/monoclonal antibody (1)Protective antigen/monoclonal antibody (1)PSMA/monoclonal antibody (1)PTK/monoclonal antibody (1)PVR/monoclonal antibody (1)PVRIG/monoclonal antibody (1)Rabies virus/monoclonal antibody (2)RAGE/monoclonal antibody (1)RANKL /monoclonal antibody (1)RG1/monoclonal antibody (1)RGMα/monoclonal antibody (1)RHD/monoclonal antibody (2)RON/monoclonal antibody (1)ROR/monoclonal antibody (1)ROR2/monoclonal antibody (1)RSPO3/monoclonal antibody (1)RSV/monoclonal antibody (4)RTN4/monoclonal antibody (1)SAA1/monoclonal antibody (1)SAP/monoclonal antibody (1)SARS-CoV/monoclonal antibody (11)Sclerostin/monoclonal antibody (2)SEMA4D/monoclonal antibody (1)Sialyl-Lewis A/monoclonal antibody (1)Siglec-15/monoclonal antibody (1)Siglec-4a/monoclonal antibody (1)SIRPα/monoclonal antibody (1)SLAMF7/monoclonal antibody (1)SLC40A1/monoclonal antibody (1)SLITRK6/monoclonal antibody (1)SpA/monoclonal antibody (1)sphingosine-1-phosphate/monoclonal antibody (1)STAB1/monoclonal antibody (1)STEAP1/monoclonal antibody (1)TAG-72/monoclonal antibody (1)Tau Protein/monoclonal antibody (2)TBFbR2/monoclonal antibody (1)TCR/monoclonal antibody (1)Tenascin-C/monoclonal antibody (1)TFPI/monoclonal antibody (1)TGF-beta/monoclonal antibody (3)TGM2/monoclonal antibody (1)Tie-2/monoclonal antibody (1)TIGIT/monoclonal antibody (5)Tim3/monoclonal antibody (3)Tissue Factor/monoclonal antibody (1)TLR/monoclonal antibody (2)TNF Receptor/monoclonal antibody (15)TNF-alpha/monoclonal antibody (5)TNF/monoclonal antibody (1)TREM2/monoclonal antibody (2)TROP2/monoclonal antibody (2)TSHR/monoclonal antibody (1)TSLP/monoclonal antibody (1)TWEAK/monoclonal antibody (1)TYRP1/monoclonal antibody (1)uPAR/monoclonal antibody (1)VAP-1/monoclonal antibody (1)VEGF/monoclonal antibody (1)VEGFC/monoclonal antibody (1)VEGFR/monoclonal antibody (5)VEGI/monoclonal antibody (2)Vimentin/monoclonal antibody (2)VISTA/monoclonal antibody (1)α-Synuclein/monoclonal antibody (2)α-toxin /monoclonal antibody (2)
Recombinant Protein
CAR-T related Proteins (141)
B Cell Maturation Antigen (BCMA) (10)B7-H3 (7)c-Met/HGFR/Recombinant Protein (4)CA-125 (3)Carbonic Anhydrase Proteins (2)CD138/Syndecan-1 (3)CD19 Proteins (2)CD20 Proteins (3)CD27 Ligand/CD70 (4)CD30 Proteins (5)CD314/NKG2D (6)CD319/SLAMF7 (5)CD38 Proteins (6)CD4 Proteins (2)CD7 Proteins (5)EGFR/Recombinant Protein (5)Epithelial Cell Adhesion Molecule (EpCAM) (5)ErbB2/HER2 (6)ErbB3/HER3 (5)FLK-1/VEGFR-2 (3)Folate Receptor alpha (FR-alpha) (6)GPC-3 (5)MUC-1/CD227 (5)Nectin-4/Recombinant Protein (9)ROR1/Recombinant Protein (7)Siglec-2/CD22 (5)Siglec-3/CD33 (6)TROP-2/Recombinant Protein (7)
CD Antigens (645)
B Cell CD Proteins (138)Dendritic Cell CD Proteins (226)Endothelial cell CD Proteins (179)Epithelial cell CD Proteins (216)Erythrocyte CD Proteins (45)Macrophage CD Proteins (317)Monocyte CD Proteins (134)NK Cell CD Proteins (176)Platelet CD Proteins (90)Stem Cell CD Proteins (165)T Cell CD Proteins (159)
Complement System (24)
Complement Component 1 (1)Complement Component 3 (2)Complement Component 5 (2)Complement Component 8 (1)Complement Receptor/Recombinant Protein (3)Complement Regulatory Proteins (13)Mannose-binding Protein (2)
Cytokines and Growth Factors (672)
Angiopoietins (14)Chemokine & Receptors (54)CSF & Receptors (35)EGF Superfamily (25)Ephrin/Eph Family (24)FGF Family (10)HGF & Receptors (4)IGF family (13)Interferon & Receptors (24)Interleukin & Receptors (208)Neurotrophic Factors (52)PDGFs & PDGFRs (4)Peptide Hormone & Neuropeptides (29)TGF-beta Superfamily (57)TNF Superfamily (145)VEGF & VEGFR (3)Other Cytokines and Growth Factors (12)
Enzymes & Regulators (244)
Carbonic Anhydrase Proteins (2)Carboxypeptidase Proteins (5)Caspase Proteins (1)Cathepsin Proteins (5)Cyclin-Dependent Kinase Inhibitor Proteins (2)Cystatin Family (12)Hydrolases (EC 3) (50)Isomerases (EC 5) (4)Lyases (EC 4) (9)Matrix Metalloproteinases (3)Oxidoreductases (EC 1) (18)Phosphatase/Recombinant Protein (6)Protease Inhibitors (42)Protein Tyrosine Kinases (79)Serine/Threonine Kinase Proteins (17)Transferases (EC 2) (15)
Fc Receptors (33)
Fc alpha RI/CD89 (1)Fc Receptor-like Proteins (2)Fc-epsilon Receptor (1)Fc-gamma Receptor (8)FcRn (5)Immunoglobulin Fc Region (16)
Immune Checkpoint Proteins (276)
Butyrophilins (24)Inhibitory Checkpoint Molecules (167)Stimulatory Immune Checkpoint Molecules (120)
Receptor Proteins (383)
Cell Adhesion Molecules (CAMs) (114)Cytokine Receptors (51)G-Protein-Coupled Receptors (GPCRs) (32)Killer-Cell Immunoglobulin-like Receptors (4)Leukocyte Immunoglobin-like Receptors (23)Notch family (6)Nuclear Receptor Superfamily (1)Pattern Recognition Receptors (18)Receptor Serine/Threonine Kinases (16)Receptor Tyrosine Kinases (81)Receptor Tyrosine Phosphatase (2)Siglec/Recombinant Protein (36)
Ubiquitin Related Proteins (5)
Deubiquitinase (2)Ubiquitin Enzymes/Recombinant Protein (2)Ubiquitin/UBLs (1)
Viral Proteins (1)
HIV Proteins (1)
Animal Modeling Reagents
Circulatory System Disease Models (11)
Cardiomyopathy Model (1)Heart Disease Correlation Model (2)Heart Failure Model (1)Hyperlipidemia Model (1)Hypertension Model (3)Thrombolysis Model (2)Vascular Inflammation Model (1)
Digestive System Disease Models (16)
Gallstone Model (1)Gastrointestinal Disease Model (7)Liver Disease Model (5)Pancreatic Disease Model (3)
Endocrine System Disease Models (12)
Aging Model (1)Diabetes Model (4)Hyperuricemia Model (8)
Immune and Inflammatory Disease Models (29)
Arthritis Model (2)Cystitis Model (1)Dermatitis Model (1)Ear Edema Model (1)Encephalomyelitis Model (2)Foot Edema Model (2)Gastrointestinal Inflammation and Ulcer Model (7)Gouty Arthritis Model (1)Liver Inflammation Model (2)Myocarditis Model (2)Nephritis Model (1)Pancreatitis Model (5)Psoriasis Model (3)Systemic Lupus Erythematosus Model (2)
Nervous System Disease Models (8)
Alzheimers Disease Model (2)Epilepsy Model (2)Neuropathic Pain Model (1)Parkinsons Disease Model (3)Schizophrenia Model (1)
Otorhinolaryngological Disease Models (4)
Cataract Model (1)Gingival Hyperplasia Model (2)Optic Neuropathy Model (1)Other Otorhinolaryngological Disease Model (1)
Respiratory System Disease Models (1)
Pulmonary Fibrosis Model (1)
Skin Disease Models (1)
Atopic Dermatitis Model (1)
Tumor Models (9)
Breast Tumor Model (2)Colon Tumor Model (1)Esophageal Tumor Model (1)Kidney Tumor Model (1)Liver Tumor Model (1)Lung Tumor Model (2)Skin Tumor Model (2)Uterine Fibroid Model (1)
Urinary System Disease Models (20)
Aging Model (1)Chronic Kidney Disease Model (2)Diabetes Model (4)Hyperuricemia Model (8)Kidney Stone Model (2)Nephrotoxicity Model (1)Renal Injury Model (5)Other Urinary System Disease Model (3)
Antibiotic and Antivirus
Function (140)
Anti-bacterial Antibiotic (2)Anti-fungal Antibiotic (7)Antivirus (63)Cell Culture Antibiotic (4)Insect Repellent (43)Plant Tissue Culture Antibiotic (7)Preservative and Disinfectant (19)
Structure (7136)
Amino Acid Derivative (1)Aminoglycoside (9)Ansamycin (3)Cephalosporin (7)Imidazole (4284)Macrolide (8)Nucleoside (43)Penicillin (3)Polypeptide (1)Pyridine / Pyrimidine (6)Quinolone (20)Sulfonamide (18)Tetracycline (6)β-Lactam (4)Other Antibiotics (36)Others (2691)
Biochemical Reagents
Amino Acids (1413)
Amino Acid Amide (20)Biologically Modified Amino Acid (27)C-protective Amino Acid (218)N-protective Amino Acid (982)Non-protein Amino Acid (132)Protein Amino Acid (64)Side Chain Protected Amino Acid (39)
Bioconjugation Reagents (406)
Biotin Linkers (378)GalNAc Linkers (28)
Biological Buffers (2732)
Good's Buffer (23)Other Buffers (19)Others (2691)
Cross-Linking Agents (56)
Amino-amino Crosslinker (13)Amino-sulfhydryl Crosslinker (15)Photoreactive Crosslinker (18)Sulfhydryl-carbonyl Crosslinker (1)Sulfhydryl-sulfhydryl Crosslinker (4)Other Reactive Crosslinkers (5)
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Chemistry
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Organic Building Blocks
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Amines
/
2-Aminobenzamide
/
Anthranilamide
/
Chemistry
/
Organic Building Blocks
/
Amines
Aryls Amides Benzene Compounds
/
2-Aminobenzamide
/
Chemical Structure| 88-68-6 Chemical Structure| 88-68-6

Structure of Anthranilamide
CAS No.: 88-68-6

Chemical Structure| 88-68-6

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Quality Control of [ 88-68-6 ] Purity: 98% SDS Specification
COA

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Product Citations

Product Citations      Show More

Verdugo, Felipe ; Braillon, Capucine ; Mahjoub, Sana ; Castro-Alvarez, Alejandro ; Janel-Bintz, Régine ; Fechter, Pierre , et al.

DOI:

Abstract: Antimicrobial resistance (AMR) remains a major threat to modern medicine, fueled by the excessive use of antibiotics and the spread of multidrug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). In this study, we designed and synthesized a series of 2-aryl-4-aminoquinazoline derivatives bearing an aminoalkylimidazole linker, combining two pharmacophoric motifs associated with antimicrobial activity. Starting from , the compounds were prepared in three straightforward steps, affording good yields and high purity. Their structures were confirmed by FT-IR spectroscopy, 1H and 13C nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS). Biological evaluation showed that series 5 exhibited strong selectivity toward S. aureus, with compounds 5c and 5d displaying minimum inhibitory concentrations (MICs) between 2.2 and 4.4 µM. No significant activity was observed against other tested strains. Cytotoxicity assays in HepG2 cells revealed moderate to low inhibition. Molecular docking indicated preferential binding to dihydrofolate reductase (DHFR) and relevant interactions with IV, resembling reference inhibitors. ADME analysis predicted favourable absorption, blood–brain barrier permeability, and compliance with Lipinski’s rules.

Keywords: aminoquinazolines ; activity ; molecular docking studies

Purchased from AmBeed: ; ; ; ;

Appiah, Samuel A ; McDonald, Matthew A ;

DOI:

Abstract: Cocrystallization can be used to tune key drug properties, such as aqueous solubility, without altering molecular structure; however, the space of possible coformers is enormous and design rules are empirical. We present a Bayesian optimization framework that couples Gaussian process (GP) classification and regression that can accelerate cocrystal discovery and solubility enhancement. Starting from 6338 literature-derived binary coformer pairs, vector fingerprints that combine 2D structural information (fragment and MQN fingerprints) with low-cost shape and polarity descriptors were engineered for cocrystal prediction. A GP classifier, trained on an actively constructed training set of ∼1000 coformer pairs selected by uncertainty sampling achieves up to 94% accuracy and Matthews correlation coefficient of 0.79 on a test set of >5000 unseen pairs. Property-driven coformer selection was formulated as a Bayesian optimization problem, using a machine learning model as a surrogate for aqueous solubility and Tanimoto-similarity to guide campaigns across several discovery scenarios. In simulations, the framework rapidly identifies highly soluble cocrystals, typically recovering top-5 candidates after fewer than 10 evaluations. Finally, we validate the workflow experimentally with 12 pharmaceutical and pharmaceutical-like compounds, discovering two new cocrystals, + and + , with markedly enhanced aqueous solubility. These results demonstrate a practical, data-efficient route to Bayesian optimization for cocrystal design.

Purchased from AmBeed: ; ; ; ; ; ; ; ; ; ; ;

Shifali Shishodia ; Raymundo Nuñez ; Brayden P. Strohmier ; Karina L. Bursch ; Christopher J. Goetz ; Michael D. Olp , et al.

DOI: PubMed ID:

Abstract: PBRM1 is a subunit of the PBAF chromatin remodeling complex that uniquely contains six bromodomains. PBRM1 can operate as a tumor suppressor or tumor promoter. PBRM1 is a tumor promoter in prostate cancer, contributing to migratory and immunosuppressive phenotypes. Selective chemical probes targeting PBRM1 bromodomains are desired to elucidate the association between aberrant PBRM1 chromatin binding and cancer pathogenesis and the contributions of PBRM1 to immunotherapy. Previous PBRM1 inhibitors unselectively bind SMARCA2 and SMARCA4 bromodomains with nanomolar potency. We used our protein-detected NMR screening pipeline to screen 1968 fragments against the second PBRM1 bromodomain, identifying 17 hits with Kd values from 45 μM to >2 mM. Structure–activity relationship studies on the tightest-binding hit resulted in nanomolar inhibitors with selectivity for PBRM1 over SMARCA2 and SMARCA4. These chemical probes inhibit the association of full-length PBRM1 to acetylated histone peptides and selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.

Purchased from AmBeed: ; ; ; ; ; ; ; ; 703-80-0 ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; 100-52-7 ; 123-11-5 ; 1711-06-4 ; 454-89-7 ; ; ; ; ; ; ; ; ; ; ; 118-92-3 ; 22458-07-7 ; ; ; ; 97-96-1 ; ; ; 89-98-5

Alternative Products

Product Details of [ 88-68-6 ]

CAS No. :88-68-6
Formula : C7H8N2O
M.W : 136.15
SMILES Code : O=C(N)C1=CC=CC=C1N
English Name :2-Aminobenzamide
MDL No. :MFCD00007981
InChI Key :PXBFMLJZNCDSMP-UHFFFAOYSA-N
Pubchem ID :6942

Safety of [ 88-68-6 ]

Computational Chemistry of [ 88-68-6 ] Show Less

Physicochemical Properties

Num. heavy atoms 10
Num. arom. heavy atoms 6
Fraction Csp3 0.0
Num. rotatable bonds 1
Num. H-bond acceptors 1.0
Num. H-bond donors 2.0
Molar Refractivity 38.94
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

69.11 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

0.96
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

0.35
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

0.38
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

0.58
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

0.26
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

0.51

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-1.28
Solubility 7.1 mg/ml ; 0.0522 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-1.37
Solubility 5.87 mg/ml ; 0.0431 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-1.6
Solubility 3.44 mg/ml ; 0.0253 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

 High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

 No
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

 No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

 No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

 No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

 No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

 No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

 No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-6.88 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

 0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

 None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

 0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

 0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

 1.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

1.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

 No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

 1.0

Application In Synthesis of [ 88-68-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 88-68-6 ]

[ 88-68-6 ] Synthesis Path-Downstream   1~19

  • 1
  • [ 123-11-5 ]
  • [ 88-68-6 ]
  • [ 1152-07-4 ]
YieldReaction ConditionsOperation in experiment
99% With iodine In ethanol Reflux; Green chemistry;
96% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 2h;
96% With pentafluorophenylammonium triflate; copper dichloride In neat (no solvent) at 70℃; for 1h;
95% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 2h;
95% With iodine; dimethyl sulfoxide for 5h; Sealed tube;
95% With potassium hydroxide In dimethyl sulfoxide at 20℃; for 6h; Irradiation;
93% With dihydrogen peroxide In tetrahydrofuran; water at 100℃; for 12h;
93% In ethanol at 80℃; for 6h; 3.2. Synthesis of 2-aryl-quinazoline-4-one derivatives 3a -e General procedure: Quinazolinone derivatives 3a -3e were prepared following a lit- erature method [18] . To a 100 mL round bottom flask, anthranil- amide 1a (1 mmol), benzaldehyde derivatives 2a -e (1 mmol) and iodine (2 equiv.) in ethanol (30 mL per mmol of 1a ) was refluxed at 80 °C for 6 h. The mixture was left to cool to room tempera- ture and quenched with cold saturated sodium metabisulfate solu- tion. The resulting precipitate was filtered and washed thoroughly with water. The solid product was recrystalised from acetonitrile and oven dried to yield the corresponding quinazoline-4(3 H )-ones 3a -3e [13] . The following products were prepared accordingly
91% With CuIL(at)SMNPs copper ionic liquid nanocatalyst; air In ethanol for 0.666667h; Reflux; Green chemistry;
90% With iron(III) chloride In water for 1h; Heating;
90% With iodine at 80℃; for 1h; Ionic liquid;
90% With bismuth (III) nitrate pentahydrate In ethanol at 60℃; for 12h; General experimental procedure for oxidative cyclocondensation of 2-aminobenzamidewith aldehydes General procedure: To a 100 mL round bottom flask fitted with a condenser containing magnetic stir bar, 1a (0.5mmol), 2a (1.2 equiv, 0.6 mmol), Bi(NO2)3• 5H2O (10 mol%), and ethanol (5 mL) were added.The resultant mixture was stirred at 60 °C under open-air condition for 12 h. The reactionmixture was cooled to rt, and subjected to crystallization (EtOH) to get analytically pure 2-phenyl-3H-quinazolin-4-one 3a (91%); 1H NMR (400 MHz, DMSO-d6) δ 12.55 (s, 1H), 8.28 - 8.10(m, 3H), 7.83 (ddd, J = 8.5, 6.4, 1.7 Hz, 1H), 7.75 (d, J = 8.2 Hz, 1H), 7.67 - 7.47 (m, 4H); 13C NMR(100 MHz, DMSO-d6) δ 162.7, 152.8, 149.2, 135.0, 133.2, 131.8, 129.1, 128.2, 127.9, 127.0,126.3, 121.4; Mass (ESI) m/z: = 222.1(M+).
89% Stage #1: 4-methoxy-benzaldehyde; anthranilic acid amide With silica gel In neat (no solvent) at 20℃; for 0.5h; Milling; Stage #2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In neat (no solvent) at 20℃; for 3h; Milling; General procedure for preparation of quinazolin-4(3H)-ones General procedure: 2-Aminobenzamide (1, 0.44 mmol, 1.0 equiv), aldehyde (2, 0.44 mmol, 1.0 equiv), 60 mg silica gel (only for liquid aldehydes) and a stainless-steel milling ball were added into a 10 mL stainless-steel jar. Milling was carried out for 30 min and then IBX (0.484 mmol, 1.1 equiv) was added to the mixture and milling was continued for 1 h. The progress of the reaction was monitored by TLC after taking a small portion of the reaction mixture and dissolving it in DCM (with the appropriate solvent as eluent). After completion of the reaction, dichloromethane was used for extracting the compound from the solid reaction mixture. The solvent was evaporated to dryness and the crude reaction mixture was purified by silica gel column chromatography using an appropriate hexane/ethyl acetate mixture.
89% With toluene-4-sulfonic acid; fluorescein free acid In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
88% With iodine; potassium carbonate In N,N-dimethyl-formamide at 60 - 80℃;
88% With tetrabutylammomium bromide; copper dichloride at 100℃; for 1.25h; Neat (no solvent);
88% With copper(II) nitrate trihydrate In acetonitrile at 80℃; for 9.5h;
88% With yttrium(III) trifluoromethanesulfonate In dimethyl sulfoxide at 110℃; 2.2 A general procedure for preparation of quinazolinones 4 General procedure: Y(OTf)3 (0.0268 g, 0.05 mmol) were dissolved in 10 mL DMSO and stirred until the solid dissolved completely, then anthranilamide 1a (0.1498 g, 1.1 mmol) and benzaldehyde 2a (0.101 mL, 1.0 mmol) was added into the reaction mixture. Then the mixture was heated at 110 under air atmosphere. After completion of the reaction, as indicated by TLC, the reaction mixture was cooled to room temperature. Water (15 mL) was added to the reaction mixture, and the crystalline products were collected by filtration to give the crude product. The crude products thus obtained were crystallized from EtOH to give pure products 4a.
87% With dimethyl sulfoxide at 85℃; for 0.916667h;
87% With indium(III) chloride In acetonitrile at 20℃; for 1h; Preparation of 2-aryl quinazolin-4(3H)-one (9) General procedure: To a solution of aromatic aldehydes 8 (1.0 mmol) in acetonitrile, o-aminobenzamide 7(1.0 mmol) and InCl3 (10 mol %) were added at room temparature and the reaction mixture was stirred till the completion of the starting materials (indicated by TLC). The solvent was evoparated and the crude product was triturated with 10% diethyl ether in hexane to obtain the pure product. The product was identified by 1H NMR, 13 C NMR and Mass.
86.7% With hydrogenchloride; nitric acid In dichloromethane; water for 0.5h; Reflux; General procedure for the synthesisof 2-substituted quinazolin-4(3H)-ones (3a-l) General procedure: To a stirring solution of 2-amino benzamide (100 mmol)and the corresponding aldehyde (100 mmol) in DCM, dropwise addition of conc. HNO3/ HCl (1 mL) was carried out andthe resulted reaction mixture was refluxed for 30 min.Reaction progress and completion was monitored by TLC andcrude product obtained after completion of the reaction wasconcentrated by a rotary evaporator. To concentrated product,water was added and precipitates so formed were filtered,washed with plenty of water and oven dried. Subsequently,recrystallization of the synthesized product with ethylacetate/ethanol (1:1) afforded crystals of 2-substitutedquinazolin-4(3H)-one.
85% With copper dichloride In ethanol for 2h; Heating;
85% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
85% In dimethyl sulfoxide at 120℃; for 48h; Inert atmosphere;
84% With aluminum oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone for 0.15h; microwave irradiation;
84% With oxygen In dimethyl sulfoxide at 100℃; for 12h; 2. Substrate Scope for 2-Substituted-4(3H)-quinazolinones 5 General procedure: Anthranilamide 1 (1.0 mmol; 1.0 equiv.) and an aldehyde 2 (1.2 mmol; 1.2 equiv.) were dissolved in DMSO (5 mL). Then, the reaction mixture was stirred at 100 oC in an open flask and monitored by TLC. After complete consumption of the starting materials, the reaction mixture was cooled to room temperature. When water (100 mL) was added to the reaction mixture, the precipitate was formed and collected by filtration. Recrystallization in ethanol afforded quinazolinone 5. The product remained inthe filtrate was further purified by column chromatography on silica using hexane / ethyl acetate (3:1 to 1:1) as an eluent to provide the desired product 5.
84% With copper(II) choride dihydrate In ethanol for 16h; Reflux; 4 General procedure for the synthesis of compounds 1-25 General procedure: In a typical procedure, 2-arylquinazolin-4(3H)-ones 1-25 were synthesized by mixing anthranilamide (2 mmol), substituted benzaldehydes (2.1 mmol) and CuCl2*2H2O (4 mmol) in ethanol (15 mL). The mixtures were refluxed for 16 h, while progress of the reaction was monitored through thin layer chromatography. After completion of reaction, the reaction mixtures were cooled to room temperature and distilled water was added until the formation of precipitates. The precipitates were filtered and washed with distilled water. This reaction afforded good yields of title compounds. 4.4.4 2-[4'-(Methyloxy)phenyl]quinazolin-4(3H)-one (4) Yield: 84%; 1H NMR: (400 MHz, DMSO-d6): δH 12.40 (s, 1H, NH), 8.18 (m, 3H, H-5, H-2', H-6'), 7.80 (m, 2H, H-7, H-8), 7.47 (s, 1H, H-6), 7.10 (d, 2H, J3',2' = J5',6' = 7.6 Hz H-3', H-5'), 3.85 (s, 3H, 4'-OCH3); EI-MS: m/z (rel. abund.%), 252 (M+, 100), 237 (3.2), 235 (2.9), 119 (64.8). Anal. Calcd for C15H12N2O2: C, 71.42; H, 4.79; N, 11.10; O, 12.68. Found: C, 71.43; H, 4.78; N, 11.11.
84% With tert.-butylhydroperoxide; fluorescein In methanol at 20℃; for 3h; Irradiation; Green chemistry;
84% With zinc(II) oxide; water at 130℃; for 6.45h; Green chemistry; General procedure for the synthesis of qunazolin-4(3H)-one derivatives 3a-3p General procedure: A mixture ofZnO-NPs (1 mmol, 0.080 g), water (2 drops), o-aminobenzamide (4 mmol), and aldehyde 2a-2p (4.8 mmol) was stirred for 5 min at room temperature. The mixturewas then heated to 130°C and stirred at that temperaturefor a time indicated in Table 2. After completion of thereaction (TLC), the mixture was cooled and treatedwith ethyl acetate (10 mL), and the catalyst was filteredoff. The ethyl acetate extract was washed with aqueoussodium bicarbonate, dried over anhydrous sodiumsulfate, and concentrated under reduced pressure. Thecrude product was purified by flash chromatography toget analytically pure products. The products were identifiedby comparing their spectral data (1H and 13CNMR and HRMS) with the literature data (Table 2).
84% With copper dichloride In ethanol for 5h; Reflux; Quinazolin-4(3H)-ones (1b-d) General procedure: were obtained similar to previously reported procedure [50]. A mixture of anthranilamide (7.3 mmol), CuCl2 (8 mmol) and the appropriate aldehyde (7.3 mmol) in ethanol (15 mL) was refluxed for 5 h. The reaction mixture was allowed to cool to rt and the resulting solid was filtered off, washed with EtOH and dried. The products 1b and 1c were purified by recrystallization from DMSO. The product 1d was purified by flesh chromatography on SiO2 with EtOAc as eluent
84% With air; mesoporous [SiO2-(CH2)3-DABCO-(CH2)4-SO3H][HSO4] In water at 100℃; for 8h; 2.4. Synthetic route of 2-phenylquinazolin-4(3H)-ones General procedure: To conduct the reaction, benzaldehyde (1.2 mmol, 159 mg) and 2- aminobenzamide (1.0 mmol, 136 mg) were combined in a roundbottom flask along with the [SiO2-(CH2)3-DABCO-(CH2)4-SO3H] [HSO4] catalyst (10 mol%). After adding water (10 mL) as the solvent, the reaction mixture was refluxed at 100 C for 8 h under ambient air conditions. The progress of the reaction was monitored using thin-layer chromatography. After the reaction was completed, the mixture was allowed to cool to room temperature. The resulting white precipitate was then filtered and recrystallized using ethanol, yielding 181 mg (81 %) of a white powder. The catalyst was separated by centrifuge, washed further with a small quantity of anhydrous ethanol (3 × 3.0 mL), and dried at 80 C for 60 min for the subsequent experiments. The derivatives of 2-arylquinazolin-4(3H)-one were isolated by a similar procedure starting from aromatic benzaldehydes. The structure of products was confirmed by 1 H NMR, 13C NMR, and MS.
83% With tert.-butylhydroperoxide In water at 110℃; for 16h; Green chemistry;
82% With iodine; potassium carbonate In N,N-dimethyl-formamide at 70 - 90℃; 4.1.2. General procedure for the preparation of the 2-phenylquinazolin-4(3H)-one derivatives 1-7 General procedure: A mixture of anthranilamide (2.72 g, 20 mmol), the corresponding pyridinecarboxaldehyde (20 mmol), iodine (3.17 g,25 mmol), anhydrous potassium carbonate (2.76 g, 20 mmol) and20 mL DMF was stirred at 70-90 °C for 4-8 h. The end of the reactionwas monitored by TLC and the mixture poured on crushedice to form a precipitate. Incomplete precipitation can be preventedby adjusting the pH with concentrated HCl solution to about 7. Afterfiltration of the precipitate, it was thoroughly washed with 100 mLof a 20% sodiumthiosulfate solution followed by 100 mL of hotdistilled water. Purification was performed by recrystallizationfrom ethanol.
80% With tert.-butylhydroperoxide In acetonitrile at 140℃; for 48h; UV-irradiation; 13 2-(4-methoxyphenyl)-4(3H)-quinazolinone, its structural formula is: In a 5.0 mL reaction vessel, 0.3 mmol of 4-methoxybenzaldehyde, 0.1 mmol of o-aminobenzamide, and 0.2 mmol of tert-butyl hydroperoxide were added, along with 2.0 mL of acetonitrile solvent. Oxygen was then introduced to create a reaction atmosphere. The reaction was then carried out at 140 °C for 48 hours under irradiation with a high-pressure mercury lamp at a maximum wavelength of 365 nm and a power of 250 W. The reaction was then stopped and cooled to room temperature. The reaction solution was diluted with dichloromethane, extracted three times with water, and the organic phase was treated with anhydrous sodium hydroxide.2SO4The product was dried, filtered, and separated by column chromatography to obtain 20.2 mg of the target product, with a yield of 80%.
79% In dimethyl sulfoxide at 100℃; General procedure for synthesis of quinazolinones (9-41, 49-66) and thienopyrimidiones (70-73) General procedure: To a solution of anthranilamide 5 (1.0 mmol, 1.0 equiv) in DMSO (5 mL) corresponding aldehyde was added (1.1 mmol, 1.1 equiv) and the reaction mixture was stirred at 100 °C in an open flask for 16-20 h. The mixture was cooled to room temperature, water (50 mL) was added, and formed precipitate was collected by filtration. Recrystallization from ethanol yielded pure quinazolinones.
79% In dimethyl sulfoxide at 100℃; for 20h; 3.1. Synthesis of Quinazolinone Derivatives General procedure: We obtained natural citral from Jiangxi Sipaisi Spice Chemical Co., Ltd. We synthesizedquinazolinone derivatives from the condensation of o-amino-benzamide and natural citralor benzaldehydes using the classical quinazolinone synthesis method. We added theo-amino-benzamides (5.0 mmol), citral or benzaldehydes (6.0 mmol), and 10 mL DMSOinto a 50 mL round-bottom flask. We carried out the reaction overnight at 100 C, and monitored the TLC until the reaction was completed (about 20 h). After the reaction wascompleted, we cooled the reaction liquid to room temperature. Then, we added 10 mLH2O to the reaction liquid, which we extracted with ethyl acetate. We dried the organiclayer with anhydrous sodium sulfate, and removed the solvent by decompression. Weused volume chromatography (eluent: petroleum ether: ethyl acetate = 5:1) to afford thedesired compound. We recorded NMR spectra on Bruker AV400 spectrometer (Bruker,Billerica, MA, USA), and HRMS on Waters Xevo G2-S QTof/Tof ACQUITY UPLC H-Classspectrometry (Waters, Milford, MA, USA).
78% With zirconocene dichloride In N,N-dimethyl-formamide at 100℃; for 7h;
78.8% With copper dichloride In <i>tert</i>-butyl alcohol at 90℃; for 15h; 4.1 (1) Synthesis of 2-(4-methoxyphenyl)-quinazolin-4(3H)-one: Weigh 50.0g of anthranilamide, 50.0g of 4-methoxybenzaldehyde, and 100.0g of CuCl2 respectively, add them to700mLof tert-butanol, stir at 90°C for 15h, and detect by TLC (developing solvent is ethyl acetate and Petroleum ether was mixed at a volume ratio of 1:1) after the reaction, 500 mL of water was added to continue heating and stirring for 1 h, filtered, and the filter cake was dried at 90 ° C to obtain a white solid 2-(4-methoxyphenyl)-quinazoline -4(3H)-one 73.1 g, yield 78.8%.
75% With iodine; oxygen In ethyl acetate for 1h; Irradiation;
74% With acetic acid at 25℃; Irradiation;
72% With starch sulphuric acid at 80℃; for 0.416667h; Green chemistry; General Procedure for the Preparation of (3H)-4-Quinazolinone Derivatives General procedure: A mixture of aldehyde (1 mmol) and2-amino benzamide (1 mmol), and starch sulphuricacid (20 W%) as a catalyst was stirred at 80 oC for25 min. The progress of reaction was monitored byTLC. After finishing, recrystallized from ethanol 95%to give pure products (2a-d)
67% With boron trifluoride diethyl etherate; potassium <i>tert</i>-butylate In 1,4-dioxane at 130℃; for 24h; Heating; Inert atmosphere; General procedure for the synthesis of 3-Methyl-2-phenylquinazolin-4(3H)-one (3a) General procedure: To a 25 mL round-bottom flask were added 2-iodo-N-methylbenzamide 1a (130.5 mg, 0.5 mmol), Benzonitrile (206 mg, 2.0 mmol), KOtBu (168 mg, 1.5 mmol) and BF3.OEt2 (35.2 mg, 0.25 mmol) in 3.0 mL of 1, 4-dioxane. The reaction mixture was heated in an oil bath at 130 °C for 24 hrs. After completion of the reaction; it was allowed to attain room temperature. The reaction mixture was quenched by saturated NaHCO3 (20 ml, PH= 10.3) solution and extracted by ethyl acetate (15 mL x 3) dried over anhydrous Na2SO4, and the solvent was removed under reduced pressure the residue was purified by column chromatography using silica gel (30% EtOAc/hexane) to afford 3a (83.1 mg; 70% yield).
65% With sodium hydrogensulfite In N,N-dimethyl acetamide Reflux;
64% With dimethyl sulfoxide at 90 - 100℃; 2.1.1. General Procedure for the Synthesis of Compounds General procedure: A mixture of 2-aminobenzamide (1 eq.), benzaldehyde (1.1 eq.) and dimethyl sulfoxide (DMSO) (5 eq.) was added to the 10 ml RBF (Round Bottom Flask). The reaction mixture was stirred on a magnetic stirrer. The progress of the reaction was monitored by using pre-coated Merck Silica gel 60 F254 TLC plates as and petroleum ether: ethyl acetate (7:3) as a mobile phase. After completion of the reaction, water was added to the reaction mixture to obtain a precipitate of the desired compound. After that, workup was performed with ethyl acetate (10 mL × 3), washed with water and brine solution. The organic layer was dried over anhydrous Na2SO4 and purified via column chromatography (EtOAc: Pet ether, 2:8). The compounds were recrystallized in the mixture of methanol/ethanol and dichloromethane(DCM).
62% With oxygen; 1-(2,2-diphenyl-2λ4,3λ4-[1,3,2]diazaborolo[4,5,1-ij]quinolin-1(2H)-yl)-3-phenylpropan-1-one In N,N-dimethyl acetamide at 20℃; for 10h; Irradiation; Green chemistry;
62% With oxygen; C31H25BNO In N,N-dimethyl acetamide for 10h; Irradiation; 10 Preparation of 2-(4-methoxyphenyl)quinazolin-4(3H)-one In this example, 2-(4-methoxyphenyl)quinazolin-4(3H)-one was prepared at milligram level. The quartz reaction tube was filled with oxygen first, and then 2-aminobenzamide (40.85mg, 0.3mmol, 1.0equiv), 4-methoxybenzaldehyde (61.27mg, 0.45mmol, 1.5equiv), PC (1.3mg, 0.003mmol, 1.0mol%), N,N-dimethylacetamide (2.0mL ) Put it into a quartz reaction tube, and react for 10 hours at 25°C under the irradiation of a blue LDE lamp with a wavelength of 455nm of 10w light intensity. At the end of the reaction, the reaction mixture was filtered, washed with ethyl acetate, and the solvent was removed by rotary evaporation, and then purified by silica gel column chromatography (the specification of silica gel is 200-300 mesh, the mass ratio of silica gel to the product to be purified is 200:1, and the eluent is petroleum ether. A mixture with a volume ratio of 10:1 and ethyl acetate) to obtain the target product 2-(4-methoxyphenyl)quinazolin-4(3H)-one with a yield of 62% (46.92 mg).
60% With iodine In acetonitrile for 24h; Reflux; 4.1.1. General procedure for the synthesis of 2-aryl-benzopyrimidinone 2 General procedure: To a mixture of 2-aminobenzamide 1 (5 mmol) and various arylaldehydes (5 mmol) in dry acetonitrile (50 mL), molecular iodine (5 mmol) was added. After the reaction was completed, the mixture was cooled to room temperature. A solution of sodium thiosulphate (5%) was added and the resulted solid was filtered off and washed with water. The crude product was recrystallized from ethanol.
52% In dimethyl sulfoxide at 100℃;
51% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 3.5h; 2-(4-Methoxyphenyl)quinazolin-4-one (51c). 2-(4-Methoxyphenyl)quinazolin-4-one (51c). 2-Aminobenzamide 49 (400 mg, 2.9 mmol) was heated with 4-methoxybenzaldehyde (395 mg, 2.9 mmol) and sodium hydrogen sulfite (454 mg, 4.3 mmol) at 150°C for 3.5 h in N,N-dimethylacetamide (3.5 mL) in an open flask. The cooled mixture was poured into water and the precipitate was collected by filtration. Chromatography (ethyl acetate / petroleum ether 3:7→ dichloromethane / methanol 99:1), followed by recrystallisation (ethyl acetate) gave 2- (4-methoxyphenyl)quinazolin-4-one 51c (330 mg, 51%) as white crystals: mp 248- 249°C (lit.76 248-249X); 1H NMR ((CD3)2SO) δ 3.83 (3 H, s, Me) 7.06 (2 H, d, J = 8.0 Hz, Ph 3,5-H2), 7.45 (1 H, m, 6-H), 7.67 (1 H, d, J = 8.0 Hz, 8-H), 7.78 (1 H, m, 7-H), 8.1 1 (1 H, dd, J = 8.0, 1.0 Hz, 5-H), 8.17 (2 H, d, J = 8.0 Hz, Ph 2,6-H2). 3C NMR ((CD3)2SO) (HSQC / HMBC) δ 55.44 (Me), 133.97 (Ph 2,6-C2), 120.68 (4a-C), 124.82 (Ph 1-C), 125.80 (5-C), 126.06 (C-6), 127.26 (C-8), 129.44 (Ph 3,5-C2), 134.47 (7-C), 148.93 (8a-C), 151.84 (Ph 4-C), 162.25 (4-C).
With iodine; potassium carbonate In N,N-dimethyl-formamide at 70 - 90℃;

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[37]Jadhav, Jagannath; Khanapure, Sharanabasappa; Salunkhe, Rajashri; Rashinkar, Gajanan [Applied Organometallic Chemistry, 2013, vol. 27, # 8, p. 486 - 488].
[38]Current Patent Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY - CN114591251, 2022, A Location in patent: Paragraph 0105-0107.
[39]Nagasawa; Matsusaki; Nobuta; Tada; Miura; Itoh [RSC Advances, 2015, vol. 5, # 78, p. 63952 - 63954].
[40]Wang, Jian; Gong, Tiancheng; Zhuang, Zirui; Sun, Bing; Zhang, Fang-Lin [Organic and Biomolecular Chemistry, 2025, vol. 23, # 18, p. 4371 - 4375].
[41]Hatamjafari, Farhad; Eslami, Sima [Oriental Journal of Chemistry, 2014, vol. 30, # 2, p. 833 - 835].
[42]Nomula, Vishnuvardhan; Rao, Sadu Nageswara [Synthetic Communications, 2021, vol. 51, # 17, p. 2602 - 2612].
[43]Location in patent: experimental part Maxwell, Aoife C.; Flanagan, Susan P.; Goddard, Richard; Guiry, Patrick J. [Tetrahedron Asymmetry, 2010, vol. 21, # 11-12, p. 1458 - 1473].
[44]Verma, Sonia; Pathania, Akashdeep Singh; Baranwal, Somesh; Kumar, Pradeep [Letters in drug design and discovery, 2020, vol. 17, # 12, p. 1552 - 1565].
[45]Wei, Lanfeng; Wei, Yu; Zhang, Jinli; Xu, Liang [Green Chemistry, 2021, vol. 23, # 12, p. 4446 - 4450].
[46]Current Patent Assignee: SHIHEZI UNIVERSITY - CN113461617, 2021, A Location in patent: Paragraph 0110-0116.
[47]Chortani, Sarra; Nimbarte, Vijaykumar D.; Horchani, Mabrouk; Ben Jannet, Hichem; Romdhane, Anis [Bioorganic Chemistry, 2019, vol. 92].
[48]Maiti, Saikat; Kim, Jaeshin; Park, Jae-Heon; Nam, Dongsik; Lee, Jae Bin; Kim, Ye-Jin; Kee, Jung-Min; Seo, Jeong Kon; Myung, Kyungjae; Rohde, Jan-Uwe; Choe, Wonyoung; Kwon, Oh-Hoon; Hong, Sung You [Journal of Organic Chemistry, 2019, vol. 84, # 11, p. 6737 - 6751].
[49]Current Patent Assignee: UNIVERSITY OF BATH - WO2014/87165, 2014, A1 Location in patent: Page/Page column 105-106.
[50]Fares, Mohamed; Eldehna, Wagdy M.; Abou-Seri, Sahar M.; Abdel-Aziz, Hatem A.; Aly, Mohamed H.; Tolba, Mai F. [Archiv der Pharmazie, 2015, vol. 348, # 2, p. 144 - 154].
  • 2
  • [ 88-68-6 ]
  • [ 104-55-2 ]
  • [ 4765-58-6 ]
YieldReaction ConditionsOperation in experiment
95% With bismuth (III) nitrate pentahydrate In ethanol at 100℃; for 12h; General experimental procedure for oxidative cyclocondensation of 2-aminobenzamidewith aldehydes General procedure: To a 100 mL round bottom flask fitted with a condenser containing magnetic stir bar, 1a (0.5mmol), 2a (1.2 equiv, 0.6 mmol), Bi(NO2)3• 5H2O (10 mol%), and ethanol (5 mL) were added.The resultant mixture was stirred at 60 °C under open-air condition for 12 h. The reactionmixture was cooled to rt, and subjected to crystallization (EtOH) to get analytically pure 2-phenyl-3H-quinazolin-4-one 3a (91%); 1H NMR (400 MHz, DMSO-d6) δ 12.55 (s, 1H), 8.28 - 8.10(m, 3H), 7.83 (ddd, J = 8.5, 6.4, 1.7 Hz, 1H), 7.75 (d, J = 8.2 Hz, 1H), 7.67 - 7.47 (m, 4H); 13C NMR(100 MHz, DMSO-d6) δ 162.7, 152.8, 149.2, 135.0, 133.2, 131.8, 129.1, 128.2, 127.9, 127.0,126.3, 121.4; Mass (ESI) m/z: = 222.1(M+).
87% With antimony chloride In neat (no solvent) for 0.05h; Microwave irradiation; Reflux;
87% With toluene-4-sulfonic acid; fluorescein free acid In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
86% With iron(III) chloride In water for 1h; Heating;
86% With tert.-butylhydroperoxide; phosphomolybdic acid In dimethyl sulfoxide at 25℃; for 5h;
76% With aluminum oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone for 0.15h; microwave irradiation;
76% With iodine; dimethyl sulfoxide for 6h; Sealed tube; Inert atmosphere;
74% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
68% With dihydrogen peroxide In ethanol; water at 78℃; for 24h;
With boron trifluoride diethyl etherate; potassium <i>tert</i>-butylate In 1,4-dioxane at 130℃; for 24h; Heating; Inert atmosphere; General procedure for the synthesis of 3-Methyl-2-phenylquinazolin-4(3H)-one (3a) General procedure: To a 25 mL round-bottom flask were added 2-iodo-N-methylbenzamide 1a (130.5 mg, 0.5 mmol), Benzonitrile (206 mg, 2.0 mmol), KOtBu (168 mg, 1.5 mmol) and BF3.OEt2 (35.2 mg, 0.25 mmol) in 3.0 mL of 1, 4-dioxane. The reaction mixture was heated in an oil bath at 130 °C for 24 hrs. After completion of the reaction; it was allowed to attain room temperature. The reaction mixture was quenched by saturated NaHCO3 (20 ml, PH= 10.3) solution and extracted by ethyl acetate (15 mL x 3) dried over anhydrous Na2SO4, and the solvent was removed under reduced pressure the residue was purified by column chromatography using silica gel (30% EtOAc/hexane) to afford 3a (83.1 mg; 70% yield).
85 % With MoO2(OC6H4NCHOC6H3Cl); dihydrogen peroxide In ethanol at 80℃;
39 % With iodine In ethanol at 80℃; Sealed tube; Green chemistry;
65 % With oxygen; safranin O; toluene-4-sulfonic acid In methanol; dimethyl sulfoxide at 20℃; Irradiation;
76 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;
Multi-step reaction with 2 steps 1: aminosulfonic acid / 0.5 h / 20 °C 2: 4-Phenylurazole; oxygen / acetonitrile / 77 h / 60 °C

References: [1]Vemula, Sandeep R.; Kumar, Dinesh; Cook, Gregory R. [Tetrahedron Letters, 2018, vol. 59, # 42, p. 3801 - 3805].
[2]Kang, Huaiyuan; Wang, Weili; Sun, Qinqiang; Yang, Shuya; Jin, Juan; Zhang, Xuewen; Ren, Xiaoliang; Zhang, Jiming; Zhou, Jianhua [Heterocyclic Communications, 2018, vol. 24, # 6, p. 293 - 296].
[3]Wang, Rongzhou; Liu, Shiyuan; Li, Longfei; Song, Ao; Yu, Shengsheng; Zhuo, Shuping; Xing, Ling-Bao [Molecular catalysis, 2021, vol. 509].
[4]Wang, Guan-Wu; Miao, Chun-Bao; Kang, Hui [Bulletin of the Chemical Society of Japan, 2006, vol. 79, # 9, p. 1426 - 1430].
[5]Chi, Mei; Xiong, Wu-Lin; Yang, Dong-Zhao; Fan, Cong-Bin; Shi, Rong-Wei; Gong, Shan-Shan; Sun, Qi [Journal of Physical Organic Chemistry, 2022, vol. 35, # 5].
[6]Santa Deepthi; Sahadeva Reddy; Reddy; Reddy [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 3, p. 220 - 222].
[7]Ge, Wenlei; Zhu, Xun; Wei, Yunyang [RSC Advances, 2013, vol. 3, # 27, p. 10817 - 10822].
[8]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[9]Rostami, Amin; Pourshiani, Omid; Navasi, Yahya; Darvishi, Neda; Saadati, Shaghayegh [New Journal of Chemistry, 2017, vol. 41, # 17, p. 9033 - 9040].
[10]Nomula, Vishnuvardhan; Rao, Sadu Nageswara [Synthetic Communications, 2021, vol. 51, # 17, p. 2602 - 2612].
[11]Feng, Mengmeng; Yan, Qingmin; Yang, Lan; Ye, Yanan; Liu, Gang; Wang, Weili [International Journal of Chemical Kinetics, 2023, vol. 55, # 3, p. 119 - 128].
[12]Kerdphon, Sutthichat; Khamto, Nopawit; Buddhachat, Kittisak; Ngoenkam, Jatuporn; Paensuwan, Pussadee; Pongcharoen, Sutatip; Singh, Thishana; Meepowpan, Puttinan; Jongcharoenkamol, Jira [ACS Medicinal Chemistry Letters, 2023, vol. 14, # 9, p. 1167 - 1173].
[13]Liu, Cheng-Hang; Wang, Jun-Jie; Xu, Mengyang; Luo, Qiyun; Wang, Ziyan; Tan, Wenyue; Zhao, Xingzeng; Jia, Xiaodong [New Journal of Chemistry, 2024, vol. 48, # 6, p. 2367 - 2370].
[14]Hu, Yongke; Tian, Hongyou; Cao, Haotian; Li, Jin; Li, Shaozhong; Li, Huaju; Li, Yanxing; Shen, Gulou; Chen, Lei [Molecular catalysis, 2024, vol. 566].
[15]Ghorashi, Nadia; Rostami, Amin [RSC Advances, 2025, vol. 15, # 43, p. 36237 - 36248].
  • 3
  • [ 88-68-6 ]
  • [ 135-02-4 ]
  • [ 1028-96-2 ]
YieldReaction ConditionsOperation in experiment
92% With iodine at 80℃; for 1h; Ionic liquid;
91% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
91% With pentafluorophenylammonium triflate; copper dichloride In neat (no solvent) at 70℃; for 1h;
90% Stage #1: anthranilic acid amide; ortho-anisaldehyde With 2,3-dicyano-5,6-dichloro-p-benzoquinone In ethanol at 78℃; for 12h; Reflux; Stage #2: In 1,2-dichloro-ethane at 85℃; for 10h; Synthesis of quinazolin-4(3H)-ones 6, 7, and 9 (generalprocedure). General procedure: The corresponding aldehyde 1, 8a, or 8b(2.5 mmol) and anthranilamide 3 (340 mg, 2.5 mmol)were suspended in ethanol (30 mL). The resulting mixturewas refl uxed for 12 h and then ethanol was distilled offunder reduced pressure. The mixture of 4 and 4 (withoutseparation) was dissolved in 1,2-dichloroethane (40 mL),the corresponding oxidant (DDQ (709 mg, 3.125 mmol),chloranil (770 mg, 3.125 mmol), or MnO2 (2.175 g,25 mmol)) was added, and the mixture was stirred at 85 Cfor 10 h. Product 6, which was prepared by the oxidationwith MnO2, was isolated by the fi ltration of the reactionmixture using a Schott glass fi lter (16 pores) followed bythe removal of the solvent from the fi ltrate by distillationunder reduced pressure. The analytical sample wasobtained by the recrystallization from acetonitrile.Products 6 and 7, which wer e prepared by the oxidationwith compounds 5a,b, were isolated from the mixture bycolumn chromatography (neutral alumina, ethyl acetateas the eluent; Rf 0.8 (7), Rf 0.5 (6)). Analytical sampleswere obtained by the recrystallization from acetonitrile.Products 9a,b were isolated from the resulting mixtureby fl ash chromatography (neutral alumina, ethyl acetateas the eluent). Analytical samples were obtained by therecrystallization from acetonitrile.
89% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 2h;
88% With yttrium(III) trifluoromethanesulfonate In dimethyl sulfoxide at 110℃; 2.2 A general procedure for preparation of quinazolinones 4 General procedure: Y(OTf)3 (0.0268 g, 0.05 mmol) were dissolved in 10 mL DMSO and stirred until the solid dissolved completely, then anthranilamide 1a (0.1498 g, 1.1 mmol) and benzaldehyde 2a (0.101 mL, 1.0 mmol) was added into the reaction mixture. Then the mixture was heated at 110 under air atmosphere. After completion of the reaction, as indicated by TLC, the reaction mixture was cooled to room temperature. Water (15 mL) was added to the reaction mixture, and the crystalline products were collected by filtration to give the crude product. The crude products thus obtained were crystallized from EtOH to give pure products 4a.
82% With iodine; potassium carbonate In N,N-dimethyl-formamide at 70 - 90℃; 4.1.2. General procedure for the preparation of the 2-phenylquinazolin-4(3H)-one derivatives 1-7 General procedure: A mixture of anthranilamide (2.72 g, 20 mmol), the corresponding pyridinecarboxaldehyde (20 mmol), iodine (3.17 g,25 mmol), anhydrous potassium carbonate (2.76 g, 20 mmol) and20 mL DMF was stirred at 70-90 °C for 4-8 h. The end of the reactionwas monitored by TLC and the mixture poured on crushedice to form a precipitate. Incomplete precipitation can be preventedby adjusting the pH with concentrated HCl solution to about 7. Afterfiltration of the precipitate, it was thoroughly washed with 100 mLof a 20% sodiumthiosulfate solution followed by 100 mL of hotdistilled water. Purification was performed by recrystallizationfrom ethanol.
81% With tetrabutylammomium bromide at 120℃; for 0.05h; Neat (no solvent); Microwave irradiation;
65% With dimethyl sulfoxide at 90 - 100℃; 2.1.1. General Procedure for the Synthesis of Compounds General procedure: A mixture of 2-aminobenzamide (1 eq.), benzaldehyde (1.1 eq.) and dimethyl sulfoxide (DMSO) (5 eq.) was added to the 10 ml RBF (Round Bottom Flask). The reaction mixture was stirred on a magnetic stirrer. The progress of the reaction was monitored by using pre-coated Merck Silica gel 60 F254 TLC plates as and petroleum ether: ethyl acetate (7:3) as a mobile phase. After completion of the reaction, water was added to the reaction mixture to obtain a precipitate of the desired compound. After that, workup was performed with ethyl acetate (10 mL × 3), washed with water and brine solution. The organic layer was dried over anhydrous Na2SO4 and purified via column chromatography (EtOAc: Pet ether, 2:8). The compounds were recrystallized in the mixture of methanol/ethanol and dichloromethane(DCM).
52% In dimethyl sulfoxide at 100℃;
In dimethyl sulfoxide at 110℃;
Multi-step reaction with 2 steps 1: aminosulfonic acid / water / 0.5 h / 20 °C / Green chemistry 2: laccase; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone / aq. phosphate buffer; acetonitrile / 24 h / 45 °C / pH 4.5 / Green chemistry; Enzymatic reaction
With sodium metabisulfite In N,N-dimethyl-formamide at 100℃; for 5h;
With oxygen In dimethyl sulfoxide at 120℃; for 24h;
86 % With tert.-butylhydroperoxide; C16H9O7(3-)*PMo12O34(OH)6Zn4(3+) In decane; 1,2-dichloro-ethane at 80℃; Inert atmosphere;
With tert.-butylhydroperoxide In dichloromethane; water at 60℃; Inert atmosphere; Schlenk technique;

References: [1]Location in patent: experimental part Wang, Xiang-Shan; Yang, Ke; Zhang, Mei-Mei; Yao, Chang-Sheng [Synthetic Communications, 2010, vol. 40, # 17, p. 2633 - 2646].
[2]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[3]Montazeri, Naser; Pourshamsian, Khalil; Yosefiyan, Soghra; Momeni, Seydeh Samaneh [Journal of Chemical Sciences, 2012, vol. 124, # 4, p. 883 - 887,5].
[4]Starnovskaya; Muzyka; Yurtaeva; Kopotilova; Kopchuk; Gaviko; Taniya; Nosova; Zyryanov; Rusinov [Russian Chemical Bulletin, 2025, vol. 74, # 2, p. 483 - 488][Izv. Akad. Nauk, Ser. Khim., 2025, vol. 74, # 2, p. 483 - 488].
[5]Hour; Huang; Kuo; Xia; Bastow; Nakanishi; Hamel; Lee [Journal of Medicinal Chemistry, 2000, vol. 43, # 23, p. 4479 - 4487].
[6]Shang, Ying-Hui; Fan, Li-Yan; Li, Xiang-Xiong; Liu, Meng-Xia [Chinese Chemical Letters, 2015, vol. 26, # 11, p. 1355 - 1358].
[7]Krapf, Michael K.; Gallus, Jennifer; Wiese, Michael [European Journal of Medicinal Chemistry, 2017, vol. 139, p. 587 - 611].
[8]Location in patent: experimental part Davoodnia; Allameh; Fakhari; Tavakoli-Hoseini [Chinese Chemical Letters, 2010, vol. 21, # 5, p. 550 - 553].
[9]Verma, Sonia; Pathania, Akashdeep Singh; Baranwal, Somesh; Kumar, Pradeep [Letters in drug design and discovery, 2020, vol. 17, # 12, p. 1552 - 1565].
[10]Dabiri, Minoo; Lehi, Noushin Farajinia; Movahed, Siyavash Kazemi; Khavasi, Hamid Reza [European Journal of Organic Chemistry, 2019, vol. 2019, # 18, p. 2933 - 2940].
[11]Fan, Zhijiang; Shi, Jun; Luo, Na; Ding, Muhan; Bao, Xiaoping [Journal of Agricultural and Food Chemistry, 2019, vol. 67, # 42, p. 11598 - 11606].
[12]Ghorashi, Nadia; Shokri, Zahra; Moradi, Reza; Abdelrasoul, Amira; Rostami, Amin [RSC Advances, 2020, vol. 10, # 24, p. 14254 - 14261].
[13]Pedrood, Keyvan; Sherafati, Maedeh; Mohammadi-Khanaposhtani, Maryam; Asgari, Mohammad Sadegh; Hosseini, Samanesadat; Rastegar, Hossein; Larijani, Bagher; Mahdavi, Mohammad; Taslimi, Parham; Erden, Yavuz; Günay, Sevilay; Gulçin, İlhami [International Journal of Biological Macromolecules, 2021, vol. 170, p. 1 - 12].
[14]Liu, Xuexin; Chen, Jian; Yang, Chunyan; Wu, Zhouping; Li, Zhiyang; Shi, Yuesen; Huang, Tianle; Yang, Zhongzhen; Wu, Yong [Organic Letters, 2021, vol. 23, # 17, p. 6831 - 6835].
[15]Huang, Xiaoxue; Zhou, Zhen; Qin, Lan; Zhang, Daopeng; Wang, Haining; Wang, Suna; Yang, Lu [Inorganic Chemistry, 2023, vol. 62, # 14, p. 5565 - 5575].
[16]Shen, Qi; Sheng, Kai; Gao, Zhi-Yong; Bilyachenko, Alexey; Huang, Xian-Qiang; Azam, Mohammad; Tung, Chen-Ho; Sun, Di [Inorganic Chemistry, 2024, vol. 63, # 28, p. 13022 - 13030].
  • 4
  • [ 98-01-1 ]
  • [ 88-68-6 ]
  • [ 26059-84-7 ]
YieldReaction ConditionsOperation in experiment
95% With oxygen In dimethyl sulfoxide at 100℃; for 18h; 2. Substrate Scope for 2-Substituted-4(3H)-quinazolinones 5 General procedure: Anthranilamide 1 (1.0 mmol; 1.0 equiv.) and an aldehyde 2 (1.2 mmol; 1.2 equiv.) were dissolved in DMSO (5 mL). Then, the reaction mixture was stirred at 100 oC in an open flask and monitored by TLC. After complete consumption of the starting materials, the reaction mixture was cooled to room temperature. When water (100 mL) was added to the reaction mixture, the precipitate was formed and collected by filtration. Recrystallization in ethanol afforded quinazolinone 5. The product remained inthe filtrate was further purified by column chromatography on silica using hexane / ethyl acetate (3:1 to 1:1) as an eluent to provide the desired product 5.
95% With graphene oxide nanosheets In water at 20℃; for 2h;
95% In dimethyl sulfoxide at 100℃; for 18h; 12 Example 1. Preparation of 2-Phenylquinazolin-4(3H)-one 1.0 mmol of anthranilamide and 1.2 mmol of benzaldehyde were added to the reaction vessel, dissolved in 5 mL of dimethyl sulfoxide, and stirred at 100° C. with an open flask system, and the progress of the reaction was confirmed by thin film chromatography in the middle. When the anthranilamide was exhausted, the reaction was terminated, and after cooling to room temperature, 100 mL of water was added to form a precipitate, followed by filtration to obtain a precipitate. The precipitate was recrystallized in ethanol to obtain the desired compound. In addition, in order to additionally obtain the target compound remaining in the crystal filtrate, the target compound was obtained by separating by silica gel column chromatography using a solvent of hexane:ethylacetate=3:1 to 1:1. Reaction time 12 hours.
94% In dimethyl sulfoxide at 120℃; for 48h; Inert atmosphere;
92% With bis(acetylacetonate)oxovanadium In N,N-dimethyl acetamide at 120℃; for 15h;
91% With bismuth (III) nitrate pentahydrate In ethanol at 60℃; for 12h; General experimental procedure for oxidative cyclocondensation of 2-aminobenzamidewith aldehydes General procedure: To a 100 mL round bottom flask fitted with a condenser containing magnetic stir bar, 1a (0.5mmol), 2a (1.2 equiv, 0.6 mmol), Bi(NO2)3• 5H2O (10 mol%), and ethanol (5 mL) were added.The resultant mixture was stirred at 60 °C under open-air condition for 12 h. The reactionmixture was cooled to rt, and subjected to crystallization (EtOH) to get analytically pure 2-phenyl-3H-quinazolin-4-one 3a (91%); 1H NMR (400 MHz, DMSO-d6) δ 12.55 (s, 1H), 8.28 - 8.10(m, 3H), 7.83 (ddd, J = 8.5, 6.4, 1.7 Hz, 1H), 7.75 (d, J = 8.2 Hz, 1H), 7.67 - 7.47 (m, 4H); 13C NMR(100 MHz, DMSO-d6) δ 162.7, 152.8, 149.2, 135.0, 133.2, 131.8, 129.1, 128.2, 127.9, 127.0,126.3, 121.4; Mass (ESI) m/z: = 222.1(M+).
88% With antimony chloride In neat (no solvent) for 0.05h; Microwave irradiation; Reflux;
87% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
86% With copper dichloride In ethanol at 70 - 75℃; for 3h;
86% With copper(II) oxide In N,N-dimethyl acetamide at 120℃; for 24h; Green chemistry;
83% With iodine; dimethyl sulfoxide for 6h; Sealed tube;
80% With iron(III) chloride In water for 1h; Heating;
77% With copper(II) nitrate trihydrate In acetonitrile at 80℃; for 10h;
76% With air; mesoporous [SiO2-(CH2)3-DABCO-(CH2)4-SO3H][HSO4] In water at 100℃; for 8h; 2.4. Synthetic route of 2-phenylquinazolin-4(3H)-ones General procedure: To conduct the reaction, benzaldehyde (1.2 mmol, 159 mg) and 2- aminobenzamide (1.0 mmol, 136 mg) were combined in a roundbottom flask along with the [SiO2-(CH2)3-DABCO-(CH2)4-SO3H] [HSO4] catalyst (10 mol%). After adding water (10 mL) as the solvent, the reaction mixture was refluxed at 100 C for 8 h under ambient air conditions. The progress of the reaction was monitored using thin-layer chromatography. After the reaction was completed, the mixture was allowed to cool to room temperature. The resulting white precipitate was then filtered and recrystallized using ethanol, yielding 181 mg (81 %) of a white powder. The catalyst was separated by centrifuge, washed further with a small quantity of anhydrous ethanol (3 × 3.0 mL), and dried at 80 C for 60 min for the subsequent experiments. The derivatives of 2-arylquinazolin-4(3H)-one were isolated by a similar procedure starting from aromatic benzaldehydes. The structure of products was confirmed by 1 H NMR, 13C NMR, and MS.
72% With dimethyl sulfoxide at 20℃; for 24h; Irradiation; Green chemistry;
70% With iodine In ethanol Reflux; Green chemistry;
61% In dimethyl sulfoxide at 100℃; General procedure for synthesis of quinazolinones (9-41, 49-66) and thienopyrimidiones (70-73) General procedure: To a solution of anthranilamide 5 (1.0 mmol, 1.0 equiv) in DMSO (5 mL) corresponding aldehyde was added (1.1 mmol, 1.1 equiv) and the reaction mixture was stirred at 100 °C in an open flask for 16-20 h. The mixture was cooled to room temperature, water (50 mL) was added, and formed precipitate was collected by filtration. Recrystallization from ethanol yielded pure quinazolinones.
46% With zirconocene dichloride In N,N-dimethyl-formamide at 100℃; for 4h;
45% With acetic acid at 25℃; Irradiation;
With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; Synthesis of Starting Materials 1 General procedure: o-Aminobenzamide (10 mmol), benzaldehyde (1.2 equiv), NaHSO3(1.2 equiv) and DMAc (50 mL) were added in a 100 mL round-bottomflask. The mixture was heated at 150 °C and the progress of the reactionwas monitored by TLC. After the reaction was complete, the mixturewas poured into ice water, and the crude product solid that precipitatedout was recrystallize from EtOH to give pure product.
With air In dimethyl sulfoxide at 120℃; for 24h; General procedure for the synthesis of (25a-c) General procedure: A mixture of anthranilamide 24 (2 mmol) and aldehyde 19 (2.4 mmol) in DMSO was stirred at120oC for 24 hrs in the open air. After completion of the reaction (monitored by TLC), the resultingmixture was poured into water (100 mL), which led to the formation of white solid. The solidswere filtered, washed with water and dried to give the corresponding quinazolinone derivatives(25a-c), which was used for the next step without further purification.
81 % With MoO2(OC6H4NCHOC6H3Cl); dihydrogen peroxide In ethanol at 80℃;
80 % Stage #1: furfural; anthranilic acid amide In methanol at 20℃; Stage #2: With acetic acid In methanol at 20℃; Electrochemical reaction; General procedure for the synthesis of 4-quinazolinones General procedure: 2-Aminobenzamide (1.0 equiv.), aldehyde (1.0 equiv.) and MeOH were added in an undivided cell. Thereaction mixture was stirred at room temperature for 5 minutes followed by addition of acetic acid (5.0equiv.). The cell was equipped with carbon anode and aluminum cathode and electrolyzed using constantcurrent of 0.35 A.cm-2 at room temperature while stirring for 3 h, whilst the reaction mixture was monitored by LCMS and TLC. Upon complete consumption of starting material, electrolysis was terminated. Reaction mixture was concentrated under reduced pressure, diluted with water (10 mL) and extracted with ethyl acetate (3×15 mL). The combined organic layer was dried over Na2SO4 and concentrated using rotary evaporator. The so obtained crude material was purified by flash chromatography on silica gel using a solvent mixture of ethyl acetate and hexane.
90 % With zinc ferrite In neat (no solvent) at 80℃; General experimental procedure for the synthesisof quinazolinone derivatives 3a-3t. General procedure: A mixtureof 2-aminobenzamide 1 (2 mmol), aldehyde 2(2 mmol), and zinc ferrite (0.048 g, 20 mol %) wasstirred at 80°C for a time indicated in Table 2. Aftercompletion of the reaction (TLC), the product wasextracted with ethyl acetate (3×5 mL), and the combinedextracts were washed with aqueous sodium hydrogen carbonate, dried over anhydrous Na2SO4, andevaporated under reduced pressure to afford analyticallypure product. All compounds 3a-3t were identifiedby comparing their spectral characteristics with literaturedata (Table 2).
85 % With sodium metabisulfite In N,N-dimethyl acetamide; water at 150℃; 3.3.4. General Procedure for the Synthesis of Quinazolin-4(3H)-Ones 3a-3g, 3k-3a General procedure: To a suspension of aldehyde 1 (1.3 mmol) and Na2S2O5 (4.5 mmol, 0.855 g) in N,Ndimethylacetamide(2.5 mL), amide 2 (1.3 mmol) and H2O (4.5 mmol, 81 L) were added.The reaction mixture was heated at 150 C for 6.5-55 h (TLC control). Then, the reactionmixture was poured into H2O (50 mL). The formed precipitate was filtered. The products3a,d,f,g,k,l,o-r,t,w,x,ab were purified using column chromatography on silica gel usingthe mixture of petroleum ether/EtOAc (1:1) as an eluent and recrystallized from a suitablesolvent. The products 3b,c,e,s,u,v,y,z,aa were recrystallized from a suitable solvent withoutprior purification using column chromatography.
With air In dimethyl sulfoxide at 100℃;
With tert.-butylhydroperoxide In dichloromethane; water at 60℃; Inert atmosphere; Schlenk technique;
82 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;
67 % In dimethyl sulfoxide at 95 - 110℃; 2.2. General Procedure for the Synthesis of Compounds General procedure: A mixture of 2-aminobenzamide (1 eq.), aldehydes (1.1"q.) and dimethyl &lfo>id" (DSO) (5 "q.) wa add"d tothe 10 ml RBF (Round Bottom Flask). The reaction mixturewas stirred on the magnetic stirrer for 24 h at 95- 110 0C.Reaction progress was checked using pre-coated MerckSilica g"l TLC plat" and p"trol"&m "t"r: ethyl acetate (`:3)as mobile phase. Water was added to the resultant mixtureafter completion of the reaction to achieve the desiredpr"cipitat". S&?"q"ntly, it wa tr"at"d wit ethyl acetate(10 mL x 3) and cleaned with water and brine solution. Theorganic sample was washed over anhydrous Na2SO4 andfiltered through column chromatography (EtOAc: Pet ether,2:8). Compounds have been recrystallized in a mixture ofmethanol/ethanol and dichloromethane (DCM) [32].
86 % With sulfonic acid functionalized Wang resin In water at 90℃;
90 % With Candida antarctica lipase B; acetic acid In water at 50℃; Green chemistry; Enzymatic reaction; General procedure for the synthesis of different heterocycles General procedure: 2-substituted anilines 1a-c/ Anthranilamide 5a (1 mmol), Aldehyde 2 (1 mmol), Water (10 mL), Cal B (50 mg), Acetic acid (0.05 eq) were charged in 50 mL round bottom flask and the reaction was carried out at 50 °C for 12 h. Substituted Ethyl acetoacetate 7a,b (1.1 mmol), aldehyde 8a-g (1 mmol), urea derivatives (1.2 mmol), Water (10 mL) Cal B (50 mg), Acetic acid (0.05 eq) were charged in 50 mL round bottom flask and the reaction was carried out at 50 °C for 12 h. After cooling to room temperature, filter-off the reaction mixture through the Hirsch funnel to remove the enzyme and wash with ethyl acetate and extracted with ethyl acetate (3x10 mL), washed with 1:1 mixture of brine. The combined organic extracts were dried over anhydrous sodium sulphate. After removal of the solvent under reduced pressure, the crude product was purified by using column chromatography, EtOAc:Hexane (10-30%) as eluent on silica gel to afford the pure products.
Multi-step reaction with 2 steps 1: C24H18N4O8V2(2-)*2H4KO2(1+) / dichloromethane / 0.5 h / Reflux 2: tert.-butylhydroperoxide; C22H16N6O8V2(2-)*2H4KO2(1+) / dichloromethane; water / 1 h / Reflux

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  • 5
  • [ 459-57-4 ]
  • [ 88-68-6 ]
  • [ 190838-76-7 ]
YieldReaction ConditionsOperation in experiment
98% With iodine at 80℃; for 0.5h; Ionic liquid;
98% With antimony chloride In neat (no solvent) for 0.05h; Microwave irradiation; Reflux;
96% With bis(acetylacetonate)oxovanadium In N,N-dimethyl acetamide at 120℃; for 15h;
94% With indium(III) chloride In acetonitrile at 20℃; for 0.75h; Preparation of 2-aryl quinazolin-4(3H)-one (9) General procedure: To a solution of aromatic aldehydes 8 (1.0 mmol) in acetonitrile, o-aminobenzamide 7(1.0 mmol) and InCl3 (10 mol %) were added at room temparature and the reaction mixture was stirred till the completion of the starting materials (indicated by TLC). The solvent was evoparated and the crude product was triturated with 10% diethyl ether in hexane to obtain the pure product. The product was identified by 1H NMR, 13 C NMR and Mass.
93% With copper(II) oxide In N,N-dimethyl acetamide at 120℃; for 24h; Green chemistry;
93% In ethanol at 80℃; for 6h; 3.2. Synthesis of 2-aryl-quinazoline-4-one derivatives 3a -e General procedure: Quinazolinone derivatives 3a -3e were prepared following a lit- erature method [18] . To a 100 mL round bottom flask, anthranil- amide 1a (1 mmol), benzaldehyde derivatives 2a -e (1 mmol) and iodine (2 equiv.) in ethanol (30 mL per mmol of 1a ) was refluxed at 80 °C for 6 h. The mixture was left to cool to room tempera- ture and quenched with cold saturated sodium metabisulfate solu- tion. The resulting precipitate was filtered and washed thoroughly with water. The solid product was recrystalised from acetonitrile and oven dried to yield the corresponding quinazoline-4(3 H )-ones 3a -3e [13] . The following products were prepared accordingly
92% In dimethyl sulfoxide at 120℃; for 48h; Inert atmosphere;
92% With zinc(II) oxide; water at 130℃; for 6.1h; Green chemistry; General procedure for the synthesis of qunazolin-4(3H)-one derivatives 3a-3p General procedure: A mixture ofZnO-NPs (1 mmol, 0.080 g), water (2 drops), o-aminobenzamide (4 mmol), and aldehyde 2a-2p (4.8 mmol) was stirred for 5 min at room temperature. The mixturewas then heated to 130°C and stirred at that temperaturefor a time indicated in Table 2. After completion of thereaction (TLC), the mixture was cooled and treatedwith ethyl acetate (10 mL), and the catalyst was filteredoff. The ethyl acetate extract was washed with aqueoussodium bicarbonate, dried over anhydrous sodiumsulfate, and concentrated under reduced pressure. Thecrude product was purified by flash chromatography toget analytically pure products. The products were identifiedby comparing their spectral data (1H and 13CNMR and HRMS) with the literature data (Table 2).
91% With pentafluorophenylammonium triflate; copper dichloride In neat (no solvent) at 70℃; for 0.833333h;
90% With tert.-butylhydroperoxide; fluorescein In methanol at 20℃; for 3h; Irradiation; Green chemistry;
88% With tert.-butylhydroperoxide In water at 110℃; for 16h; Green chemistry;
88% With yttrium(III) trifluoromethanesulfonate In dimethyl sulfoxide at 110℃; 2.2 A general procedure for preparation of quinazolinones 4 General procedure: Y(OTf)3 (0.0268 g, 0.05 mmol) were dissolved in 10 mL DMSO and stirred until the solid dissolved completely, then anthranilamide 1a (0.1498 g, 1.1 mmol) and benzaldehyde 2a (0.101 mL, 1.0 mmol) was added into the reaction mixture. Then the mixture was heated at 110 under air atmosphere. After completion of the reaction, as indicated by TLC, the reaction mixture was cooled to room temperature. Water (15 mL) was added to the reaction mixture, and the crystalline products were collected by filtration to give the crude product. The crude products thus obtained were crystallized from EtOH to give pure products 4a.
87% With iodine; potassium carbonate In N,N-dimethyl-formamide at 60 - 80℃;
87% With dihydrogen peroxide In tetrahydrofuran; water at 100℃; for 12h;
87% With air; mesoporous [SiO2-(CH2)3-DABCO-(CH2)4-SO3H][HSO4] In water at 100℃; for 8h; 2.4. Synthetic route of 2-phenylquinazolin-4(3H)-ones General procedure: To conduct the reaction, benzaldehyde (1.2 mmol, 159 mg) and 2- aminobenzamide (1.0 mmol, 136 mg) were combined in a roundbottom flask along with the [SiO2-(CH2)3-DABCO-(CH2)4-SO3H] [HSO4] catalyst (10 mol%). After adding water (10 mL) as the solvent, the reaction mixture was refluxed at 100 C for 8 h under ambient air conditions. The progress of the reaction was monitored using thin-layer chromatography. After the reaction was completed, the mixture was allowed to cool to room temperature. The resulting white precipitate was then filtered and recrystallized using ethanol, yielding 181 mg (81 %) of a white powder. The catalyst was separated by centrifuge, washed further with a small quantity of anhydrous ethanol (3 × 3.0 mL), and dried at 80 C for 60 min for the subsequent experiments. The derivatives of 2-arylquinazolin-4(3H)-one were isolated by a similar procedure starting from aromatic benzaldehydes. The structure of products was confirmed by 1 H NMR, 13C NMR, and MS.
85% With iodine; oxygen In ethyl acetate for 15h; Irradiation;
81% With toluene-4-sulfonic acid; fluorescein free acid In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
81% With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tert-butylammonium hexafluorophosphate(V) In water; acetonitrile at 20℃; for 3h; Electrochemical reaction;
79% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
79% With oxygen; 1-(2,2-diphenyl-2λ4,3λ4-[1,3,2]diazaborolo[4,5,1-ij]quinolin-1(2H)-yl)-3-phenylpropan-1-one In N,N-dimethyl acetamide at 20℃; for 10h; Irradiation; Green chemistry;
79% With oxygen; C31H25BNO In N,N-dimethyl acetamide for 10h; Irradiation; 9 Preparation of 2-(4-fluorophenyl)quinazolin-4(3H)-one In this example, 2-(4-fluorophenyl)quinazolin-4(3H)-one was prepared at milligram level. The quartz reaction tube was filled with oxygen first, and then 2-aminobenzamide (40.85mg, 0.3mmol , 1.0equiv), 4-fluorobenzaldehyde (55.85mg, 0.45mmol, 1.5equiv), PC (1.3mg, 0.003mmol, 1.0mol%), N,N-dimethylacetamide (2.0mL) was added to the quartz reaction In the tube, the reaction was carried out at 25°C for 10 hours under the irradiation of a blue LDE lamp with a wavelength of 455nm of 10w light intensity. At the end of the reaction, the reaction mixture was filtered, washed with ethyl acetate, and the solvent was removed by rotary evaporation, and then purified by silica gel column chromatography (the specification of silica gel is 200-300 mesh, the mass ratio of silica gel to the product to be purified is 200:1, and the eluent is petroleum ether. A mixture with a volume ratio of 10:1 and ethyl acetate) to obtain the target product 2-(4-fluorophenyl)quinazolin-4(3H)-one with a yield of 79% (56.94 mg).
76% With zirconocene dichloride In N,N-dimethyl-formamide at 100℃; for 4h;
74% With tert.-butylhydroperoxide In acetonitrile at 140℃; for 48h; UV-irradiation; 9 2-(4-fluorophenyl)-4(3H)-quinazolinone, its structural formula is: In a 5.0 mL reaction vessel, 0.3 mmol of 4-fluorobenzaldehyde, 0.1 mmol of o-aminobenzamide, and 0.2 mmol of tert-butyl hydroperoxide were added, followed by 2.0 mL of acetonitrile solvent. Oxygen was then introduced to create a reaction atmosphere. The reaction was then carried out at 140 °C for 48 hours under irradiation with a high-pressure mercury lamp at a maximum wavelength of 365 nm and a power of 250 W. The reaction was then stopped and cooled to room temperature. The reaction solution was diluted with dichloromethane, extracted three times with water, and the organic phase was treated with anhydrous sodium hydroxide.2SO4The product was dried, filtered, and separated by column chromatography to obtain 17.8 mg of the target product, with a yield of 74%.
62% With dihydrogen peroxide In ethanol; water at 78℃; for 48h;
59% Stage #1: 4-fluorobenzaldehyde; anthranilic acid amide In neat (no solvent) at 20℃; for 0.5h; Milling; Stage #2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In neat (no solvent) at 20℃; for 1h; Milling; General procedure for preparation of quinazolin-4(3H)-ones General procedure: 2-Aminobenzamide (1, 0.44 mmol, 1.0 equiv), aldehyde (2, 0.44 mmol, 1.0 equiv), 60 mg silica gel (only for liquid aldehydes) and a stainless-steel milling ball were added into a 10 mL stainless-steel jar. Milling was carried out for 30 min and then IBX (0.484 mmol, 1.1 equiv) was added to the mixture and milling was continued for 1 h. The progress of the reaction was monitored by TLC after taking a small portion of the reaction mixture and dissolving it in DCM (with the appropriate solvent as eluent). After completion of the reaction, dichloromethane was used for extracting the compound from the solid reaction mixture. The solvent was evaporated to dryness and the crude reaction mixture was purified by silica gel column chromatography using an appropriate hexane/ethyl acetate mixture.
57% With sodium hydrogensulfite at 150℃; for 3.5h; 2-(4-Fluorophenyl)quinazolin-4-one (51 g). 2-(4-Fluorophenyl)quinazolin-4-one (51 g). 2-Aminobenzamide 49 (400 mg, 2.9 mmol) was heated with 4-fluorobenzaldehyde (360 mg, 2.9 mmol) and sodium hydrogen sulfite (454 mg, 4.3 mmol) at 150°C for 3.5 h in N,N-dimethylacetamide (3.5 mL) in an open flask. The cooled mixture was poured into water and the precipitate was collected by filtration. Recrystallisation (dichloromethane / petroleum ether) gave 2-(4-fluorophenyl)quinazolin-4-one 51 g (400 mg, 57%) as a white solid: mp 286-289°C (lit.78 288-289°C); 1H NMR ((CD3)2SO) δ 7.39 (2 H, m, Ph 3,5-H2), 7.52 (1 H, t d, J = 7.0, 1.0 Hz, 6-H), 7.74 (1 H, dd, J = 8.0, 0.5 Hz, 8-H), 7.83 (1 H, m, 7-H), 8.15 (1 H, dd, J = 8.0, 1.5 Hz, 5-H), 8.25 (2 H, m, Ph 2,5-H2), 12.56 (1 H, s, NH); 13C NMR ((CD3)2SO) (HMBC / HSQC) δ 115.59 (d, J = 21.7 Hz, Ph 3,5-C2), 120.85 (4a-C), 125.83 (5-C), 126.57 (6-C), 127.36 (8-C), 129.24 (Ph 1-C), 130.24 (d, J = 9.0 Hz, Ph 2,6-C2), 134.60 (7-C), 148.57 (8a-C), 151.54 (2-C), 162.18 (4-C), 164.02 (d, J = 248.0 Hz, Ph 4-C).
56% In dimethyl sulfoxide at 100℃; General procedure for synthesis of quinazolinones (9-41, 49-66) and thienopyrimidiones (70-73) General procedure: To a solution of anthranilamide 5 (1.0 mmol, 1.0 equiv) in DMSO (5 mL) corresponding aldehyde was added (1.1 mmol, 1.1 equiv) and the reaction mixture was stirred at 100 °C in an open flask for 16-20 h. The mixture was cooled to room temperature, water (50 mL) was added, and formed precipitate was collected by filtration. Recrystallization from ethanol yielded pure quinazolinones.
44% In dimethyl sulfoxide at 100℃;
With N,N-dimethyl acetamide; sodium hydrogensulfite at 180℃; 3.1 All the chemical reagents and solvents, which were analyticallypure without further purification, were commercially available.4-Fluoro-benzaldehyde, anthranilamide, and dimethylacetamidewere purchased from Boka Chemical (Shanghai, China). 2-(4-Fluorophenyl)-quinazolin-4(3H)-one (FQ, the chemical structure isshown in Fig. 1) was synthesized from condensation of anthranilamideand 4-Fluoro-benzaldehyde. 4-Fluoro-benzaldehyde(0.025 g, 0.2 mmol) and anthranilamide (0.055 g, 0.4 mmol) wasadded to a solution of NaHSO3 (0.042 g, 0.4 mmol) in dimethylacetamide(DMAc). After being stirred overnight at 180 C, the solventwas removed under reduced pressure, and the residue waspurified on 0.20 mm silica gel 60 F254 plates (Shanghai LianhuaTechnology, China) to provide the product FQ. 1H nuclear magneticresonance (1H NMR), 13C nuclear magnetic resonance (13C NMR)spectra were recorded on a Bruker AV400 spectrometer (Bruker,USA), using DMSO-d6 as an internal standard, FTIR was on a Nicolet6700 FT-IR spectrometer (Thermo fisher, USA), and HRMS wason a Waters Xevo G2-S QTof/Tof ACQUITY UPLC H-Class spectrometry(Waters, USA).
In dimethyl sulfoxide at 110℃;
With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; Synthesis of Starting Materials 1 General procedure: o-Aminobenzamide (10 mmol), benzaldehyde (1.2 equiv), NaHSO3(1.2 equiv) and DMAc (50 mL) were added in a 100 mL round-bottomflask. The mixture was heated at 150 °C and the progress of the reactionwas monitored by TLC. After the reaction was complete, the mixturewas poured into ice water, and the crude product solid that precipitatedout was recrystallize from EtOH to give pure product.
39.2 mg With toluene-4-sulfonic acid; fluorescein In acetonitrile for 2h; Irradiation; 13 Anthranilamide (27.2 mg, 0.2 mmol),4-fluorobenzaldehyde (24.8 mg, 0.2 mmol),Fluorescein (1.3 mg, 2 mol%),P-toluenesulfonic acid (3.4 mg, 10 mol%) and acetonitrile (2 mL)Add them to the 15 mL reaction tube one by one.The reaction mixture was reacted for 2 h under the irradiation of 10 w blue light,After the reaction, the solvent was removed by rotary evaporation, and then column chromatography (developing solvent: petroleum ether/ethyl acetate volume ratio = 3:1) to obtain the pure target compound as a white solid (39.2 mg),
With oxygen In dimethyl sulfoxide at 120℃; for 24h;
With air In dimethyl sulfoxide at 120℃; for 24h; General procedure for the synthesis of (25a-c) General procedure: A mixture of anthranilamide 24 (2 mmol) and aldehyde 19 (2.4 mmol) in DMSO was stirred at120oC for 24 hrs in the open air. After completion of the reaction (monitored by TLC), the resultingmixture was poured into water (100 mL), which led to the formation of white solid. The solidswere filtered, washed with water and dried to give the corresponding quinazolinone derivatives(25a-c), which was used for the next step without further purification.
In dimethyl sulfoxide at 140℃;
In dimethyl sulfoxide at 120℃; for 48h;
91 % With 0.24 mmol/g nickel(II) complex immobilized on MCM-41 mesoporous silica In ethanol Heating; 2.3. General method for the synthesis of benzimidazole and quinazolinone General procedure: Aldehyde (1.00 mmol), o-phenylenediamine (1.00 mmol) or anthranilamide (1.00 mmol)ethanol (1.5 mL) and MCM-41PDCA-Ni (20 mg) were mixed in a round bottom flaskand the reaction was allowed to stir at 60 C. Once the reaction was complete as indicatedby TLC (ethyl acetate:n-hexane, 2:5), the solid product obtained was dissolved inethanol and filtered. On addition of water to the filtered solution, white precipitatewas obtained.
94 % With MoO2(OC6H4NCHOC6H3Cl); dihydrogen peroxide In ethanol at 80℃;
92 % With zinc ferrite In neat (no solvent) at 80℃; General experimental procedure for the synthesisof quinazolinone derivatives 3a-3t. General procedure: A mixtureof 2-aminobenzamide 1 (2 mmol), aldehyde 2(2 mmol), and zinc ferrite (0.048 g, 20 mol %) wasstirred at 80°C for a time indicated in Table 2. Aftercompletion of the reaction (TLC), the product wasextracted with ethyl acetate (3×5 mL), and the combinedextracts were washed with aqueous sodium hydrogen carbonate, dried over anhydrous Na2SO4, andevaporated under reduced pressure to afford analyticallypure product. All compounds 3a-3t were identifiedby comparing their spectral characteristics with literaturedata (Table 2).
76.4% With iodine In ethanol Reflux; General procedure A for the preparation of 1a-1d General procedure: The preparation of 1 were accomplished using a known literature procedure1-2.To the mixture of 2-aminobenzamide (340.4 mg, 2.5 mmol) and benzaldehyde (2.5mmol, 1.0 equiv) in EtOH (10 mL) was added I2 (5.0 mmol, 2.0 equiv). The mixturewas refluxed for 5 h (Figure 4). Then cool the mixture to room temperature andfiltrate, wash the products withethyl acetate and petroleum ether (40: 60). Finally,compounds 1a-1d was obtained by vacuum drying.Compound 1a: Compound 1a was prepared according to the General Procedure Ausing p-fluorobenzaldehyde to afford 458.8 mg (76.4%) ofcompound 1a as a white solid. Mp: 270-272 ; 1H NMR (600MHz, DMSO-d6) δ 12.58 (bs, 1H), 8.33 - 8.21 (m, 2H), 8.16 (d,J = 7.8 Hz, 1H), 7.85 (t, J = 7.2 Hz, 1H), 7.74 (d, J = 7.8 Hz, 1H),7.53 (t, J = 7.8 Hz, 1H), 7.40 (t, J = 8.4 Hz, 2H) ppm;HRMSMALDI (m/z) calcd for [C14H10FN2O]+, 241.0772; found,241.0776. Spectroscopic data was agreement with the literature3.
76.4% With iodine In ethanol Reflux; General procedure A for the preparation of 1a-1d General procedure: The preparation of 1 were accomplished using a known literature procedure1-2.To the mixture of 2-aminobenzamide (340.4 mg, 2.5 mmol) and benzaldehyde (2.5mmol, 1.0 equiv) in EtOH (10 mL) was added I2 (5.0 mmol, 2.0 equiv). The mixturewas refluxed for 5 h (Figure 4). Then cool the mixture to room temperature andfiltrate, wash the products withethyl acetate and petroleum ether (40: 60). Finally,compounds 1a-1d was obtained by vacuum drying.Compound 1a: Compound 1a was prepared according to the General Procedure Ausing p-fluorobenzaldehyde to afford 458.8 mg (76.4%) ofcompound 1a as a white solid. Mp: 270-272 ; 1H NMR (600MHz, DMSO-d6) δ 12.58 (bs, 1H), 8.33 - 8.21 (m, 2H), 8.16 (d,J = 7.8 Hz, 1H), 7.85 (t, J = 7.2 Hz, 1H), 7.74 (d, J = 7.8 Hz, 1H),7.53 (t, J = 7.8 Hz, 1H), 7.40 (t, J = 8.4 Hz, 2H) ppm;HRMSMALDI (m/z) calcd for [C14H10FN2O]+, 241.0772; found,241.0776. Spectroscopic data was agreement with the literature3.
86 % With oxygen; safranin O; toluene-4-sulfonic acid In methanol; dimethyl sulfoxide at 20℃; Irradiation;
With air In dimethyl sulfoxide at 100℃;
80% With iodine In acetonitrile Inert atmosphere;
With tert.-butylhydroperoxide In dichloromethane; water at 60℃; Inert atmosphere; Schlenk technique;
80 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;
70% With C26H40N2O2(1+)*HO4S(1-); sodium nitrite at 120℃; Green chemistry; 6.1.3 Synthesis of quinazolin-4(3H)-ones General procedure: Anthranilamide (50 mg, 0.36 mmol), Benzyl alcohol derivatives (53-60, 0.44 mmol), [TEMPOLQ8][HSO4] (56-60 mg, 25 mol% w.r.t. benzyl alcohols), NaNO2 (14-16 mg, 0.21 mmol) were subjected to round bottom flask fitted with a condenser under 120 °C for 6 hours. After completion of the reaction, the mixture was extracted with ethyl acetate (3 × 10 mL) and washed with water (3 × 10 mL). The combined extract was dried over anhydrous Na2SO4. The filtrate was concentrated under reduced pressure. The product was purified by column chromatography over silica gel using n-hexane/ethyl acetate (3:1 v/v) as eluent to get the purified product (Table 7 ).
Multi-step reaction with 2 steps 1: C24H18N4O8V2(2-)*2H4KO2(1+) / dichloromethane / 0.5 h / Reflux 2: tert.-butylhydroperoxide; C24H18N4O8V2(2-)*2H4KO2(1+) / dichloromethane; water / 1 h / Reflux
With air In dimethyl sulfoxide at 120℃; for 24h;
49 %Spectr. With oxygen In ethanol for 3h; Schlenk technique; Irradiation;

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  • 6
  • [ 1122-91-4 ]
  • [ 88-68-6 ]
  • [ 83800-88-8 ]
YieldReaction ConditionsOperation in experiment
99% With iodine at 80℃; for 0.75h; Ionic liquid;
95% With 2,3-dicyano-5,6-dichloro-p-benzoquinone for 1h; Milling; Synthesis of 2-phenylquinazolin-4(3H)-one: General procedure: In a 10 mL of stainless-steel jar, 2-aminobenzamide (60 mg, 0.441 mmol), benzaldehyde (0.441 mmol, 1 equiv), DDQ (100 mg,0.441 mmol) and one stainless-steel milling ball were added. Then, the milling process was carried out for 1 h at 21 Hz and the progress of the reaction was monitored by TLC. After consumption of all starting material, the reaction mixture was extracted with 15 mL (3 × 5 mL)dichloromethane. The organic extract was evaporated to dryness in vacuum and the residue purified by silica gel column chromatography with hexane/ethyl acetate mixture as eluent.
94% With yttrium(III) trifluoromethanesulfonate In dimethyl sulfoxide at 110℃; 2.2 A general procedure for preparation of quinazolinones 4 General procedure: Y(OTf)3 (0.0268 g, 0.05 mmol) were dissolved in 10 mL DMSO and stirred until the solid dissolved completely, then anthranilamide 1a (0.1498 g, 1.1 mmol) and benzaldehyde 2a (0.101 mL, 1.0 mmol) was added into the reaction mixture. Then the mixture was heated at 110 under air atmosphere. After completion of the reaction, as indicated by TLC, the reaction mixture was cooled to room temperature. Water (15 mL) was added to the reaction mixture, and the crystalline products were collected by filtration to give the crude product. The crude products thus obtained were crystallized from EtOH to give pure products 4a.
92% With tetrabutylammomium bromide at 120℃; for 0.05h; Neat (no solvent); Microwave irradiation;
92% With indium(III) chloride In acetonitrile at 20℃; for 0.75h; Preparation of 2-aryl quinazolin-4(3H)-one (9) General procedure: To a solution of aromatic aldehydes 8 (1.0 mmol) in acetonitrile, o-aminobenzamide 7(1.0 mmol) and InCl3 (10 mol %) were added at room temparature and the reaction mixture was stirred till the completion of the starting materials (indicated by TLC). The solvent was evoparated and the crude product was triturated with 10% diethyl ether in hexane to obtain the pure product. The product was identified by 1H NMR, 13 C NMR and Mass.
92% With CuIL(at)SMNPs copper ionic liquid nanocatalyst; air In ethanol for 0.5h; Reflux; Green chemistry;
92% With tert.-butylhydroperoxide; fluorescein In methanol at 20℃; for 3h; Irradiation; Green chemistry;
91% In ethanol at 80℃; for 6h; 3.2. Synthesis of 2-aryl-quinazoline-4-one derivatives 3a -e General procedure: Quinazolinone derivatives 3a -3e were prepared following a lit- erature method [18] . To a 100 mL round bottom flask, anthranil- amide 1a (1 mmol), benzaldehyde derivatives 2a -e (1 mmol) and iodine (2 equiv.) in ethanol (30 mL per mmol of 1a ) was refluxed at 80 °C for 6 h. The mixture was left to cool to room tempera- ture and quenched with cold saturated sodium metabisulfate solu- tion. The resulting precipitate was filtered and washed thoroughly with water. The solid product was recrystalised from acetonitrile and oven dried to yield the corresponding quinazoline-4(3 H )-ones 3a -3e [13] . The following products were prepared accordingly
90% With dihydrogen peroxide In tetrahydrofuran; water at 100℃; for 12h;
89% With iodine; dimethyl sulfoxide for 5h; Sealed tube;
89.44% Stage #1: anthranilic acid amide With sodium acetate In N,N-dimethyl-formamide for 0.166667h; Stage #2: 4-bromo-benzaldehyde With iodine In N,N-dimethyl-formamide at 70 - 80℃; for 24h; 3 General procedure for the synthesis of 5a-t General procedure: To the stirring solution of 2-aminobenzamide (1 equivalent) in DMF, sodium acetate (2 equivalents) was added. After stirring for- 10min, substituted benzaldehydes (1 equivalent, 7a-g and 9h-t) and iodine (2 equivalents) were added. The reaction mixture was stirred at 70-80°C for 20-24h. Then the reaction mixture was poured on to crushed ice. The resulting mixture was treated with sodium thiosulphate (10% w/v in water) to reduce the remaining iodine. The precipitate was filtered off and washed with petroleum ether (40:60): ethyl acetate in 1:1 ratio.
89% With zinc(II) oxide; water at 130℃; for 6.3h; Green chemistry; General procedure for the synthesis of qunazolin-4(3H)-one derivatives 3a-3p General procedure: A mixture ofZnO-NPs (1 mmol, 0.080 g), water (2 drops), o-aminobenzamide (4 mmol), and aldehyde 2a-2p (4.8 mmol) was stirred for 5 min at room temperature. The mixturewas then heated to 130°C and stirred at that temperaturefor a time indicated in Table 2. After completion of thereaction (TLC), the mixture was cooled and treatedwith ethyl acetate (10 mL), and the catalyst was filteredoff. The ethyl acetate extract was washed with aqueoussodium bicarbonate, dried over anhydrous sodiumsulfate, and concentrated under reduced pressure. Thecrude product was purified by flash chromatography toget analytically pure products. The products were identifiedby comparing their spectral data (1H and 13CNMR and HRMS) with the literature data (Table 2).
88% With copper(II) oxide In N,N-dimethyl acetamide at 120℃; for 24h; Green chemistry;
87% With iron(III) chloride In water for 1h; Heating;
85% With bis(acetylacetonate)oxovanadium In N,N-dimethyl acetamide at 120℃; for 15h;
85% With air; mesoporous [SiO2-(CH2)3-DABCO-(CH2)4-SO3H][HSO4] In water at 100℃; for 8h; 2.4. Synthetic route of 2-phenylquinazolin-4(3H)-ones General procedure: To conduct the reaction, benzaldehyde (1.2 mmol, 159 mg) and 2- aminobenzamide (1.0 mmol, 136 mg) were combined in a roundbottom flask along with the [SiO2-(CH2)3-DABCO-(CH2)4-SO3H] [HSO4] catalyst (10 mol%). After adding water (10 mL) as the solvent, the reaction mixture was refluxed at 100 C for 8 h under ambient air conditions. The progress of the reaction was monitored using thin-layer chromatography. After the reaction was completed, the mixture was allowed to cool to room temperature. The resulting white precipitate was then filtered and recrystallized using ethanol, yielding 181 mg (81 %) of a white powder. The catalyst was separated by centrifuge, washed further with a small quantity of anhydrous ethanol (3 × 3.0 mL), and dried at 80 C for 60 min for the subsequent experiments. The derivatives of 2-arylquinazolin-4(3H)-one were isolated by a similar procedure starting from aromatic benzaldehydes. The structure of products was confirmed by 1 H NMR, 13C NMR, and MS.
84% In dimethyl sulfoxide at 120℃; for 48h; Inert atmosphere;
83% With toluene-4-sulfonic acid; fluorescein free acid In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
82% With iodine; oxygen In ethyl acetate for 15h; Irradiation;
82% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
81% With pentafluorophenylammonium triflate; copper dichloride In neat (no solvent) at 70℃; for 1h;
78% Stage #1: 4-bromo-benzaldehyde; anthranilic acid amide In neat (no solvent) at 20℃; for 0.5h; Milling; Stage #2: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In neat (no solvent) at 20℃; for 0.5h; Milling; General procedure for preparation of quinazolin-4(3H)-ones General procedure: 2-Aminobenzamide (1, 0.44 mmol, 1.0 equiv), aldehyde (2, 0.44 mmol, 1.0 equiv), 60 mg silica gel (only for liquid aldehydes) and a stainless-steel milling ball were added into a 10 mL stainless-steel jar. Milling was carried out for 30 min and then IBX (0.484 mmol, 1.1 equiv) was added to the mixture and milling was continued for 1 h. The progress of the reaction was monitored by TLC after taking a small portion of the reaction mixture and dissolving it in DCM (with the appropriate solvent as eluent). After completion of the reaction, dichloromethane was used for extracting the compound from the solid reaction mixture. The solvent was evaporated to dryness and the crude reaction mixture was purified by silica gel column chromatography using an appropriate hexane/ethyl acetate mixture.
75% With zirconocene dichloride In N,N-dimethyl-formamide at 100℃; for 6h;
70% With tert.-butylhydroperoxide In acetonitrile at 140℃; for 48h; UV-irradiation; 11 2-(4-bromophenyl)-4(3H)-quinazolinone, its structural formula is: In a 5.0 mL reaction vessel, 0.3 mmol of 4-bromobenzaldehyde, 0.1 mmol of o-aminobenzamide, and 0.2 mmol of tert-butyl hydroperoxide were added, along with 2.0 mL of acetonitrile solvent. Oxygen was then introduced to create a reaction atmosphere. The reaction was then carried out at 140 °C for 48 hours under irradiation with a high-pressure mercury lamp at a maximum wavelength of 365 nm and a power of 250 W. The reaction was then stopped and cooled to room temperature. The reaction solution was diluted with dichloromethane, extracted three times with water, and the organic phase was treated with anhydrous sodium chloride.2SO4The product was dried, filtered, and separated by column chromatography to obtain 21.1 mg of the target product, with a yield of 70%.
59% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 4h; 13 A solution of 2-aminobenzamide (5.00 g, 36.7 mmol), 4-bromobenzaldehyde (6.79 g, 36.7 mmol), and sodium hydrogen sulfite (3.90 g, 37.5 mmol), in Λ/,Λ/-dimethylacetamide (100 ml_) was heated (150°C) for 2 h. An additional amount of sodium hydrogen sulfite (3.90 g, 37.5 mmol) was added to the reaction and the reaction mixture was heated (150°C) for an additional 2 h. The reaction was cooled to rt and was poured over ice water (800 ml_). The mixture was allowed to warm to rt and the resulting precipitate was collected by filtration and washed with water. After air drying, the crude material was recrystallized from ethanol to obtain 6.54 g (59%) of the desired product. 1H NMR (300 MHz, DMSO-c/6) δ 12.59 (s, 1 H), 8.15-8.08 (m, 3 H), 7.85-7.80 (m, 1 H), EPO 7.77-7.71 (m, 3 H), 7.55-7.49 (m, 1 H); ES-MS m/z 301.2 [M+H] LCMS RT (min) 2.86.
57% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 3.5h; 2-(4-Bromophenyl)quinazolin-4-one (51 e). 2-(4-Bromophenyl)quinazolin-4-one (51 e). 2-Aminobenzamide 49 (400 mg, 2.9 mmol) was heated with 4-bromobenzaldehyde (542 mg, 2.9 mmol) and sodium hydrogen sulfite (454 mg, 4.3 mmol) at 150°C for 3.5 h in N,N-dimethylacetamide (3.5 mL) in an open flask. The cooled mixture was poured into water and the precipitate was collected by filtration. The solid was recrystallised (dimethylformamide / petroleum ether) to give 2-(4-bromophenyl)quinazolin-4-one 51 e (500 mg, 57%) as a white solid: mp 287-290X (lit.77 296-297°C); 1H NMR ((CD3)2SO) δ 7.54 (1 H, m, 6-H), 7.73-7.77 (3 H, m, 8-H + Ph 3,5-H2), 7.83-7.86 (1 H, m, 7-H), 8.13 (2 H, d, J = 7.0 Hz, Ph 2,6-H2), 8.16 (1 H, dd, J = 8.0, 1.5 Hz, 5-H), 12.61 (1 H, s, NH); 13C NMR ((CD3)2SO) (HSQC / HMBC) δ 121.66 (4a-C), 125.89 (5-C), 126.54 (6-C), 127.44 (7-C), 128.15 (Ph 4-C), 130.46 (Ph 2,6-C2), 132.28 (Ph 3,5-C2), 132.59 (Ph 1 -C), 135.33 (8-C), 148.21 (8a-C), 152.16 (2-C), 162.85 (4-C).
53% In dimethyl sulfoxide at 100℃;
42% In dimethyl sulfoxide at 100℃;
Multi-step reaction with 2 steps 1: water / 2 h / Reflux 2: C5H11IrO3(2+)*2CF3O3S(1-) / water / 1 h / Reflux
With oxygen In dimethyl sulfoxide; N,N-dimethyl-formamide at 120℃; for 12h; 2.2 Catalytic studies General procedure: In a typical experiment, a solution of phenylacetic acid (0.3mmol, 40.8mg) in DMF (0.5mL) was added to a 10mL vial with the VNU-21 catalyst (5.5mg, 5mol%). The mixture was stirred at 120°C for 4h under an oxygen atmosphere. After that, the catalyst was removed by filtration. A solution of 2-aminobenzamide (0.2mmol, 27.2mg) in DMSO (0.5mL) was then added to the reactor. The mixture was additionally stirred at 120°C for 5h under oxygen. The GC yield of benzaldehyde and 2-phenylquinazolin-2(3H)-one were monitored by withdrawing samples from the reaction mixture, quenching with brine (1mL), extracting with ethyl acetate (3×1mL), drying over anhydrous Na2SO4, and analyzing by GC regarding diphenyl ether as internal standard. After the completion of the second step, the reaction mixture was cooled to room temperature. Resulting solution was quenched with brine (5mL), extracted by ethyl acetate (3×5mL), dried over anhydrous Na2SO4 prior to the removal of solvent under vacuum. The crude product was purified by silica gel column chromatography using hexane and ethyl acetate (1:1, v/v) as eluent. The structure of 2-phenylquinazolin-4(3H)-one was verified by GC-MS, 1H NMR and 13C NMR. For the leaching test, after the first 4h reaction time, the catalyst was removed by filtration. The solution phase was transferred to a new and clean reactor. New phenylacetic acid was added, and the resulting mixture was subsequently stirred for additional 4h at 120°C under an oxygen atmosphere. The yield of benzaldehyde was monitored by GC.
With hydrogenchloride; nitric acid In dichloromethane; water for 0.5h; Reflux; General procedure for the synthesisof 2-substituted quinazolin-4(3H)-ones (3a-l) General procedure: To a stirring solution of 2-amino benzamide (100 mmol)and the corresponding aldehyde (100 mmol) in DCM, dropwise addition of conc. HNO3/ HCl (1 mL) was carried out andthe resulted reaction mixture was refluxed for 30 min.Reaction progress and completion was monitored by TLC andcrude product obtained after completion of the reaction wasconcentrated by a rotary evaporator. To concentrated product,water was added and precipitates so formed were filtered,washed with plenty of water and oven dried. Subsequently,recrystallization of the synthesized product with ethylacetate/ethanol (1:1) afforded crystals of 2-substitutedquinazolin-4(3H)-one.
In dimethyl sulfoxide at 110℃;
With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; Synthesis of Starting Materials 1 General procedure: o-Aminobenzamide (10 mmol), benzaldehyde (1.2 equiv), NaHSO3(1.2 equiv) and DMAc (50 mL) were added in a 100 mL round-bottomflask. The mixture was heated at 150 °C and the progress of the reactionwas monitored by TLC. After the reaction was complete, the mixturewas poured into ice water, and the crude product solid that precipitatedout was recrystallize from EtOH to give pure product.
With oxygen In dimethyl sulfoxide at 120℃; for 24h;
With oxygen In dimethyl sulfoxide at 120℃; for 24h; Sealed tube;
0.68 g Stage #1: 4-bromo-benzaldehyde; anthranilic acid amide In ethanol for 3h; Reflux; Stage #2: With copper dichloride In ethanol for 5h; Reflux; 2-(4-Bromophenyl)quinazolin-4(3H)-one (8a). The mixture of 7aand 7a’ (0.81 g, 2.66 mmol) was dissolved in ethanol (13 mL), CuCl2(0.59 g, 4.37 mmol) was added, and the reaction mixture was refluxedfor 5 h. After cooling the formed quinazolinone 8a was filtered off andwashed with ethanol (3 mL). Colorless solid, yield 0.68 g (85%),mp >300 C (mp lit. 298-300 C [66]). 1H NMR (400 MHz, DMSO-d6): δ 7.54(m, 1H, H-6 or H-7), 7.76 (m, 3H, H-5, H-3′ , H-5′ ), 7.85 (m, 1H, H-6 orH-7), 8.14 (m, 3H, H-8, H-2′ , H-6’), 12.60 (br. s, 1H, NH).
In dimethyl sulfoxide at 120℃; for 48h;
0.68 g Stage #1: 4-bromo-benzaldehyde; anthranilic acid amide In ethanol for 3h; Reflux; Stage #2: With copper dichloride In ethanol for 5h; Reflux; 2-(4-Bromophenyl)quinazolin-4(3H)-one (8a). The mixture of 7aand 7a’ (0.81 g, 2.66 mmol) was dissolved in ethanol (13 mL), CuCl2(0.59 g, 4.37 mmol) was added, and the reaction mixture was refluxedfor 5 h. After cooling the formed quinazolinone 8a was filtered off andwashed with ethanol (3 mL). Colorless solid, yield 0.68 g (85%),mp >300 C (mp lit. 298-300 C [66]). 1H NMR (400 MHz, DMSO-d6): δ 7.54(m, 1H, H-6 or H-7), 7.76 (m, 3H, H-5, H-3′ , H-5′ ), 7.85 (m, 1H, H-6 orH-7), 8.14 (m, 3H, H-8, H-2′ , H-6’), 12.60 (br. s, 1H, NH).
87 % With MoO2(OC6H4NCHOC6H3Cl); dihydrogen peroxide In ethanol at 80℃;
94 % With zinc ferrite In neat (no solvent) at 80℃; General experimental procedure for the synthesisof quinazolinone derivatives 3a-3t. General procedure: A mixtureof 2-aminobenzamide 1 (2 mmol), aldehyde 2(2 mmol), and zinc ferrite (0.048 g, 20 mol %) wasstirred at 80°C for a time indicated in Table 2. Aftercompletion of the reaction (TLC), the product wasextracted with ethyl acetate (3×5 mL), and the combinedextracts were washed with aqueous sodium hydrogen carbonate, dried over anhydrous Na2SO4, andevaporated under reduced pressure to afford analyticallypure product. All compounds 3a-3t were identifiedby comparing their spectral characteristics with literaturedata (Table 2).
With iodine In ethanol Reflux; Compound 1 General procedure: To the mixture of 2-aminobenzamide (680.8 mg, 5.0 mmol) and benzaldehyde(5.0 mmol, 1.0 equiv) in EtOH (15 mL) was added I2 (10.0 mmol, 2.0 equiv). Themixture was refluxed for 5 h. Then cool the mixture to room temperature and filtrate,wash the products withethyl acetate and petroleum ether (40: 60) to give products 1.
92 % With oxygen; safranin O; toluene-4-sulfonic acid In methanol; dimethyl sulfoxide at 20℃; Irradiation;
In dimethyl sulfoxide at 100℃;
2.9 g With iodine In ethanol Reflux; 1.1 Example 1 (1) o-Aminobenzamide (1 g, 7.34 mmol, 1.0 equiv) and 4-bromobenzaldehyde (1.36 g, 7.34 mmol, 1.0 equiv) were dissolved in 20 mL of anhydrous ethanol, and iodine (1.864 g, 7.34 mmol, 1.0 equiv) was added. The reaction mixture was refluxed for 8 h. After the reaction was completed, the unreacted iodine was treated with 40 mL of saturated sodium thiosulfate aqueous solution, the mixture was filtered, and washed with petroleum ether: ethyl acetate = 1:1 to obtain the product 2-(4-bromophenyl)quinazolin-4(3H)-one (3a) (2.9 g) as a white solid.
88 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;
90 % With Candida antarctica lipase B; acetic acid In water at 50℃; Green chemistry; Enzymatic reaction; General procedure for the synthesis of different heterocycles General procedure: 2-substituted anilines 1a-c/ Anthranilamide 5a (1 mmol), Aldehyde 2 (1 mmol), Water (10 mL), Cal B (50 mg), Acetic acid (0.05 eq) were charged in 50 mL round bottom flask and the reaction was carried out at 50 °C for 12 h. Substituted Ethyl acetoacetate 7a,b (1.1 mmol), aldehyde 8a-g (1 mmol), urea derivatives (1.2 mmol), Water (10 mL) Cal B (50 mg), Acetic acid (0.05 eq) were charged in 50 mL round bottom flask and the reaction was carried out at 50 °C for 12 h. After cooling to room temperature, filter-off the reaction mixture through the Hirsch funnel to remove the enzyme and wash with ethyl acetate and extracted with ethyl acetate (3x10 mL), washed with 1:1 mixture of brine. The combined organic extracts were dried over anhydrous sodium sulphate. After removal of the solvent under reduced pressure, the crude product was purified by using column chromatography, EtOAc:Hexane (10-30%) as eluent on silica gel to afford the pure products.
Multi-step reaction with 2 steps 1: C24H18N4O8V2(2-)*2H4KO2(1+) / dichloromethane / 0.5 h / Reflux 2: tert.-butylhydroperoxide; C24H18N4O8V2(2-)*2H4KO2(1+) / dichloromethane; water / 1 h / Reflux
46 %Spectr. With oxygen In ethanol for 3h; Schlenk technique; Irradiation;
Multi-step reaction with 2 steps 1: aminosulfonic acid / 0.5 h / 20 °C 2: 2,3-dicyano-5,6-dichloro-p-benzoquinone; oxygen / acetonitrile / 18 h / 60 °C
With biphenyl; oxygen; Zn4 (4,4'-azobispyridine)8 (V2O7)4.H2O In acetonitrile at 90℃; for 2h;

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  • 7
  • [ 50-00-0 ]
  • [ 88-68-6 ]
  • [ 491-36-1 ]
YieldReaction ConditionsOperation in experiment
92% With iron(III) chloride In water for 1h; Heating;
82% With [Cp*Ir(2,2′-bpyO)(H2O)]; caesium carbonate In toluene at 130℃; for 2h; Microwave irradiation;
82% With toluene-4-sulfonic acid; fluorescein free acid In water at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
80% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
68% With iodine In ethanol Reflux; Green chemistry;
68% In water at 120 - 130℃; for 24h;
67% With oxygen In dimethyl sulfoxide at 100℃; for 36h; 2. Substrate Scope for 2-Substituted-4(3H)-quinazolinones 5 General procedure: Anthranilamide 1 (1.0 mmol; 1.0 equiv.) and an aldehyde 2 (1.2 mmol; 1.2 equiv.) were dissolved in DMSO (5 mL). Then, the reaction mixture was stirred at 100 oC in an open flask and monitored by TLC. After complete consumption of the starting materials, the reaction mixture was cooled to room temperature. When water (100 mL) was added to the reaction mixture, the precipitate was formed and collected by filtration. Recrystallization in ethanol afforded quinazolinone 5. The product remained inthe filtrate was further purified by column chromatography on silica using hexane / ethyl acetate (3:1 to 1:1) as an eluent to provide the desired product 5.
60% With acetic acid at 25℃; Irradiation;
55% With iodine; oxygen In water; dimethyl sulfoxide at 110℃; for 4h;
12% With ytterbium(III) triflate In 1,3,5-trimethyl-benzene at 165℃; for 6h; Inert atmosphere; General procedure: A mixture of 2-aminobenzamide (1, 4.0 mmol), carboxamide (2, 6.0 mmol), Yb(OTf)3 (0.20 mmol,5.0 mol%), and mesitylene (5.0 mL) was placed in a 20-mL Pyrex flask equipped with a magnetic stirring bar and a reflux condenser under a flow of argon. The reaction was carried out at 120-165 oC (bath temp.) for 6 h with stirring. Then, the reaction mixture was cooled to room temperature, and analyzed by GLC, GC-MS (EI), and LC-MS (ESI). After evaporation of mesitylene under vacuum,the products (3) were isolated by recrystallization from MeOH/hexane and/or medium pressure column chromatography on silica gel (eluent: EtOAc/hexane = 50/50 ~ EtOAc 100%. For 3j, eluent:MeOH/CHCl3 = 50/50). 1H NMR spectra were recorded at 400 MHz, and 13C NMR spectra wererecorded at 100 MHz in DMSO-d6. The analytical and spectral data of 3a-e,38 3f,39 3g,40 3h,41 and3j,42 were consistent with those reported previously. The product, 3i, was characterized below.
24.1 mg With toluene-4-sulfonic acid; fluorescein In water; acetonitrile at 20℃; for 2h; Irradiation; 1.1; 2.1; 3.1; 4.1; 5.1; 1 Step 1. Anthranilamide (27.2 mg, 0.2 mmol), aqueous formaldehyde solution (37wt%) (16.2 mg, 0.2 mmol), fluorescein (1.3 mg, 2 mol%), p-toluenesulfonic acid (3.4 mg , 10 mol%) and acetonitrile (2 mL) were sequentially added to the 15 mL reaction tube. The reaction mixture was reacted at room temperature for 2 h under the irradiation of a 10 w blue light lamp. After the reaction, the solvent was removed by rotary evaporation, and then column chromatography (developing solvent: petroleum ether/ethyl acetate volume ratio = 3:1) to obtain purity The target compound quinazolin-4-one was a white solid (24.1 mg).
With tert.-butylhydroperoxide In dichloromethane; water at 60℃; Inert atmosphere; Schlenk technique;
45 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;

References: [1]Wang, Guan-Wu; Miao, Chun-Bao; Kang, Hui [Bulletin of the Chemical Society of Japan, 2006, vol. 79, # 9, p. 1426 - 1430].
[2]Li, Feng; Lu, Lei; Liu, Pengcheng [Organic Letters, 2016, vol. 18, # 11, p. 2580 - 2583].
[3]Wang, Rongzhou; Liu, Shiyuan; Li, Longfei; Song, Ao; Yu, Shengsheng; Zhuo, Shuping; Xing, Ling-Bao [Molecular catalysis, 2021, vol. 509].
[4]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[5]Tian, Xianhai; Song, Lina; Li, Ertong; Wang, Qiang; Yu, Wenquan; Chang, Junbiao [RSC Advances, 2015, vol. 5, # 76, p. 62194 - 62201].
[6]Hu, Ben-Quan; Cui, Jie; Wang, Li-Xia; Tang, Ya-Lin; Yang, Luo [RSC Advances, 2016, vol. 6, # 50, p. 43950 - 43953].
[7]Kim, Na Yeun; Cheon, Cheol-Hong [Tetrahedron Letters, 2014, vol. 55, # 15, p. 2340 - 2344].
[8]Wang, Jian; Gong, Tiancheng; Zhuang, Zirui; Sun, Bing; Zhang, Fang-Lin [Organic and Biomolecular Chemistry, 2025, vol. 23, # 18, p. 4371 - 4375].
[9]Abdullaha, Mohd; Mohammed, Shabber; Ali, Mehboob; Kumar, Ajay; Vishwakarma, Ram A.; Bharate, Sandip B. [Journal of Organic Chemistry, 2019, vol. 84, # 9, p. 5129 - 5140].
[10]Yoshimura, Tsutomu; Yuanjun, Di; Kimura, Yu; Yamada, Hisatsugu; Toshimitsu, Akio; Kondo, Teruyuki [Heterocycles, 2015, vol. 90, # 2, p. 857 - 865].
[11]Current Patent Assignee: SHANDONG UNIVERSITY OF TECHNOLOGY - CN113200927, 2021, A Location in patent: Paragraph 0024; 0027-0028; 0030; 0032; 0034.
[12]Shen, Qi; Sheng, Kai; Gao, Zhi-Yong; Bilyachenko, Alexey; Huang, Xian-Qiang; Azam, Mohammad; Tung, Chen-Ho; Sun, Di [Inorganic Chemistry, 2024, vol. 63, # 28, p. 13022 - 13030].
[13]Hu, Yongke; Tian, Hongyou; Cao, Haotian; Li, Jin; Li, Shaozhong; Li, Huaju; Li, Yanxing; Shen, Gulou; Chen, Lei [Molecular catalysis, 2024, vol. 566].
  • 8
  • [ 88-68-6 ]
  • [ 456-48-4 ]
  • [ 138867-17-1 ]
YieldReaction ConditionsOperation in experiment
85% With dimethyl sulfoxide at 85℃; for 0.916667h;
81% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
75% Stage #1: anthranilic acid amide; 3-Fluorobenzaldehyde With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With [bis(acetoxy)iodo]benzene In tetrahydrofuran Inert atmosphere;
73% With air; mesoporous [SiO2-(CH2)3-DABCO-(CH2)4-SO3H][HSO4] In water at 100℃; for 8h; 2.4. Synthetic route of 2-phenylquinazolin-4(3H)-ones General procedure: To conduct the reaction, benzaldehyde (1.2 mmol, 159 mg) and 2- aminobenzamide (1.0 mmol, 136 mg) were combined in a roundbottom flask along with the [SiO2-(CH2)3-DABCO-(CH2)4-SO3H] [HSO4] catalyst (10 mol%). After adding water (10 mL) as the solvent, the reaction mixture was refluxed at 100 C for 8 h under ambient air conditions. The progress of the reaction was monitored using thin-layer chromatography. After the reaction was completed, the mixture was allowed to cool to room temperature. The resulting white precipitate was then filtered and recrystallized using ethanol, yielding 181 mg (81 %) of a white powder. The catalyst was separated by centrifuge, washed further with a small quantity of anhydrous ethanol (3 × 3.0 mL), and dried at 80 C for 60 min for the subsequent experiments. The derivatives of 2-arylquinazolin-4(3H)-one were isolated by a similar procedure starting from aromatic benzaldehydes. The structure of products was confirmed by 1 H NMR, 13C NMR, and MS.
65% With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 3h; 2.3. General procedure for synthesis of 6-substituted-2-(3-substituted phenyl)-4-quinazolinones (4-7) General procedure: Sodium hydrogen sulfite (0.8 g, 7.5 mmol) was added to a solution of 2-aminobenzamide (3a) (1.0 g, 7.3 mmol) and benzaldehyde (0.8 g, 7.3 mmol) in N,N-dimethylacetamide (DMAC) (20 mL). The mixture was heated with stirring at 150 °C for 3 h and poured into ice water (200 mL). The precipitate was collected, washed with water, and dried in vacuo. After purification by column chromatography (silica gel; chloroform) and followed recrystallization from EtOH, 2-phenyl-4-quinazolinone (4) was obtained (1.1 g) as white needles. Yield, melting point, and spectral data of 4 and all subsequent compounds are summarized in Table 1. The method used to prepare 4 was used with the indicated substituted benzaldehyde and benzamide to afford 5-7.
Stage #1: anthranilic acid amide; 3-Fluorobenzaldehyde With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With [bis(acetoxy)iodo]benzene In tetrahydrofuran Inert atmosphere;
In dimethyl sulfoxide at 110℃;
Multi-step reaction with 2 steps 1: aminosulfonic acid / water / 0.5 h / 20 °C / Green chemistry 2: laccase; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone / aq. phosphate buffer; acetonitrile / 24 h / 45 °C / pH 4.5 / Green chemistry; Enzymatic reaction
92 % With MoO2(OC6H4NCHOC6H3Cl); dihydrogen peroxide In ethanol at 80℃;
55% With C26H40N2O2(1+)*HO4S(1-); sodium nitrite at 120℃; Green chemistry; 6.1.3 Synthesis of quinazolin-4(3H)-ones General procedure: Anthranilamide (50 mg, 0.36 mmol), Benzyl alcohol derivatives (53-60, 0.44 mmol), [TEMPOLQ8][HSO4] (56-60 mg, 25 mol% w.r.t. benzyl alcohols), NaNO2 (14-16 mg, 0.21 mmol) were subjected to round bottom flask fitted with a condenser under 120 °C for 6 hours. After completion of the reaction, the mixture was extracted with ethyl acetate (3 × 10 mL) and washed with water (3 × 10 mL). The combined extract was dried over anhydrous Na2SO4. The filtrate was concentrated under reduced pressure. The product was purified by column chromatography over silica gel using n-hexane/ethyl acetate (3:1 v/v) as eluent to get the purified product (Table 7 ).

References: [1]Chen, Jiuxi; Wu, Dengze; He, Fei; Liu, Miaochang; Wu, Huayue; Ding, Jinchang; Su, Weike [Tetrahedron Letters, 2008, vol. 49, # 23, p. 3814 - 3818].
[2]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[3]Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V. [Journal of Organic Chemistry, 2019, vol. 84, # 5, p. 2951 - 2961].
[4]Nguyen, The Thai; Wu, Jhao-Yang; Tsai, Yi-Chou; Tran, Phuong Hoang [Journal of Molecular Liquids, 2025, vol. 433].
[5]Location in patent: experimental part Hour, Mann-Jen; Yang, Jai-Sing; Chen, Tai-Lin; Chen, Kuan-Tin; Kuo, Sheng-Chu; Chung, Jing-Gung; Lu, Chi-Cheng; Chen, Chia-Yi; Chuang, Yi-Hsuan [European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2709 - 2721].
[6]Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V. [Journal of Organic Chemistry, 2019, vol. 84, # 5, p. 2951 - 2961].
[7]Fan, Zhijiang; Shi, Jun; Luo, Na; Ding, Muhan; Bao, Xiaoping [Journal of Agricultural and Food Chemistry, 2019, vol. 67, # 42, p. 11598 - 11606].
[8]Ghorashi, Nadia; Shokri, Zahra; Moradi, Reza; Abdelrasoul, Amira; Rostami, Amin [RSC Advances, 2020, vol. 10, # 24, p. 14254 - 14261].
[9]Feng, Mengmeng; Yan, Qingmin; Yang, Lan; Ye, Yanan; Liu, Gang; Wang, Weili [International Journal of Chemical Kinetics, 2023, vol. 55, # 3, p. 119 - 128].
[10]Dutta, Bidyutjyoti; Adhikari, Narayan; Borah, Ramyata Priyam; Bhattacharyya, Bishal; Sarma, Diganta [Journal of Molecular Structure, 2025, vol. 1322].
  • 9
  • [ 123-72-8 ]
  • [ 88-68-6 ]
  • [ 1091619-53-2 ]
YieldReaction ConditionsOperation in experiment
98% With copper(II)-L-histidine on the surface Fe3O4 magnetic nanoparticle In ethanol at 80℃; for 0.283333h; Reflux; Green chemistry;
95% With copper(II) chloride supported Fe3O4-N,N,N",N"-tetraethyldiethylenetriamine magnetic nanoparticle In ethanol at 80℃; for 0.5h; 7.3 General synthesis for the preparation of 2,3-dihydroquinazolin-4(1H)-ones General procedure: A mixture of aldehydes 1 (1 mmol), 2-aminobenzamide 2 (1 mmol) and CuCl2/Fe3O4-TEDETA (5 mg) in ethanol (10 mL) was stirred and heated at 80°C. Reaction progress was monitored by TLC (acetone:n-hexane, 2:8). After the TLC indicates the disappearance of starting materials, the reaction was cooled to room temperature. The catalyst was separated by an external magnet and reused as such for the next experiment. The filtrate was evaporated to remove solvent, the resultant solid was then washed with ethanol to obtain pure 2,3-dihydroquinazolin-4(1H)-ones in 95-98% yields.
95% With boehmite silica dopamine sulfamic acid In ethanol at 80℃; for 0.833333h;
94% With ammonium chloride In ethanol at 20℃; for 0.833333h;
94% With copper(II) Schiff base complex supported on Fe3O4 In ethanol for 0.5h; Reflux; Green chemistry;
93% With Ni(II)-schiff base complex grafted in mesoporous silica MCM-41 In water at 20℃; for 0.75h;
93% With vanadium oxide-vanillin complex immobilized onto mesoporous MCM-41 In water at 90℃; for 1.16667h; Green chemistry;
92% With BF3-grafted Fe3O4(at)sucrose nanoparticles at 20℃; for 0.25h;
91% With acid-base carbamodithioic acid bi-functionalized silica-coated Fe2O3 magnetite nanoparticles catalyst In neat (no solvent) at 50℃; for 0.25h; Green chemistry;
86% In tert-Amyl alcohol at 120℃; for 12h;
85% With cellulosesulfonic acid In acetonitrile at 20℃; for 0.8h; 11 General procedure: A mixture of carbonyl compound (1 mmol), anthranilamide (1 mmol), and cellulose-SO3H (50 mg) in acetonitrile (5 mL) was stirred at room temperature for a specified time (Table 1). After completion of the reaction, as indicated by TLC, the catalyst was filtered and washed with ethyl acetate (2 × 10 mL) and the resulting filtrate was dried over Na2SO4 and concentrated under vacuum. The product was purified by silica gel column chromatography (50:50, hexane/ethyl acetate) to afford the pure 2,3-dihydroquinazolin-4(1H)-one. The products thus obtained were characterized by IR, NMR and mass spectroscopy. The spectral data were found to be consistent with authentic samples.
80% With scandium tris(trifluoromethanesulfonate); (S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine In dichloromethane at 25℃; for 48h; Molecular sieve;
75% With Amberlyst-15 In acetonitrile at 20℃; for 1h;
70% With L-proline nitrate In acetonitrile at 20℃; Green chemistry; General Procedure General procedure: The mixture of anthranilamide (1.46 mmol), aldehydes (1.46 mmol) and L-proline nitrate (10 mol%) was stirred at room temperature in acetonitrile (0.5 mL). The progress of the reaction wasmonitored by TLC. After completion of reaction (20 min), the solid obtained was filtered andrecrystallized using ethanol to get 3a-o. To recover the catalyst, filtrate containing IL catalystwas evaporated under reduced pressure. The residue obtained was washed with a little amount ofwater to get an aqueous solution of the catalyst. Water from this solution was removed underreduced pressure and the last trace of water was removed by forming azeotrope with a smallamount of toluene to get the catalyst which is then available for the next run.
68% With 25,26,27,28-terahydroxycalix[4]arene-5,11,7,23-tetrasulfonic acid In water at 20℃; for 0.666667h; Green chemistry;
In water for 2h; Reflux; 18 2-propylquinazolin-4(3Η)-one Aminobenzamide (136 mg, lmmol), N-butyraldehyde (72 mg, lmmol), Water (1. OmL) Added in turn5mL single mouth bottle. The mixture was reacted at reflux temperature for 2 hours and then cooled to room temperature. Then add [Cp * Ir (H20) 3][0Tf] 2 (6.8 mg, 0. ol mmol, 1 mol%), reacted at reflux temperature for 1 hour, and then cooled to room temperature. Vacuum removed under pressureThe solvent was then passed through a column chromatography (developing solvent): Ethyl acetate / n-hexane) to give the pure title compound,Yield: 81%.
With tetrabutylammonium perchlorate; toluene-4-sulfonic acid In acetonitrile at 20℃; for 3h;
85 % With montmorillonite K-10 at 20℃; Milling; General procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones (3a-3q) General procedure: A mixture containing 2-aminobenzamide or 5-chloro-2-aminobenzamide (0.5mmol), the appropriate aldehyde (0.5mmol), and K-10 (1.5g) was added to a clean and dry ball-milling vessel (12mL) with two stainless steel grinding balls (d 10mm). Afterwards the milling process was started at 450rpm. Progress of the reaction was monitored by TLC using chloroform:methanol 19:1 (v/v) as the eluting solvent. After the reaction was completed, ethyl acetate (30mL) was added to the solid mixture and, after stirring for 10min, the mixture was filtered. Then the obtained filtrate was concentrated under reduced pressure. The obtained product was purified by recrystallization from ethanol. All of the compounds in this study were known materials, identified by matching their melting points with those in the literature cited in Table 2. Satisfactory microanalysis was obtained for compound 3h, where the observed and literature melting points differed. Representative data are provided below for the sake of completeness.

References: [1]Norouzi, Masoomeh; Ghorbani-Choghamarani, Arash; Nikoorazm, Mohsen [RSC Advances, 2016, vol. 6, # 95, p. 92387 - 92401].
[2]Ghorbani-Choghamarani, Arash; Norouzi., Masoomeh [Journal of Molecular Catalysis A: Chemical, 2014, vol. 395, p. 172 - 179].
[3]Hajjami, Maryam; Ghorbani-Choghamarani, Arash; Ghafouri-Nejad, Raziyeh; Tahmasbi, Bahman [New Journal of Chemistry, 2016, vol. 40, # 4, p. 3066 - 3074].
[4]Shaabani, Ahmad; Maleki, Ali; Mofakham, Hamid [Synthetic Communications, 2008, vol. 38, # 21, p. 3751 - 3759].
[5]Ghorbani-Choghamarani, Arash; Darvishnejad, Zahra; Norouzi, Masoomeh [Applied Organometallic Chemistry, 2015, vol. 29, # 10, p. 707 - 711].
[6]Nikoorazm, Mohsen; Ghorbani-Choghamarani, Arash; Khanmoradi, Maryam [RSC Advances, 2016, vol. 6, # 61, p. 56549 - 56561].
[7]Nikoorazm, Mohsen; Khanmoradi, Maryam [Journal of the Chinese Chemical Society, 2020, vol. 67, # 8, p. 1477 - 1489].
[8]Radfar, Iman; Miraki, Maryam Kazemi; Ghandi, Leila; Esfandiary, Naghmeh; Abbasi, Sepideh; Karimi, Meghdad; Heydari, Akbar [Applied Organometallic Chemistry, 2018, vol. 32, # 8].
[9]Mohammadi Metkazini, Fatemeh; Khorsandi, Zahra; Heydari, Akbar [Molecular catalysis, 2021, vol. 506].
[10]Chen, Xiaozhong; Xu, Yong; Zhao, Wei; Wang, Xiaoting; Shi, Qixun; Zhang, Shouhai; Li, Feng [Organic Letters, 2025, vol. 27, # 15, p. 3858 - 3864].
[11]Location in patent: experimental part Subba Reddy; Venkateswarlu; Madan; Vinu [Tetrahedron Letters, 2011, vol. 52, # 16, p. 1891 - 1894].
[12]Prakash, Muthuraj; Jayakumar, Samydurai; Kesavan, Venkitasamy [Synthesis, 2013, vol. 45, # 16, p. 2265 - 2272].
[13]Bharate, Sandip B.; Mupparapu, Nagaraju; Manda, Sudhakar; Bharate, Jaideep B.; Mudududdla, Ramesh; Yadav, Rammohan R.; Vishwakarma, Ram A. [ARKIVOC, 2012, vol. 2012, # 8, p. 308 - 318].
[14]Bahekar, Sandeep P.; Dahake, Nityanand D.; Sarode, Prashant B.; Chandak, Hemant S. [Synlett, 2015, vol. 26, # 18, p. 2575 - 2577].
[15]Rahman, Matiur; Ling, Irene; Abdullah, Norbani; Hashim, Rauzah; Hajra, Alakananda [RSC Advances, 2015, vol. 5, # 10, p. 7755 - 7760].
[16]Current Patent Assignee: NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY - CN106518789, 2017, A Location in patent: Paragraph 0117-0120.
[17]Cao, Liu; Huo, Hengrui; Zeng, Haipeng; Yu, Yu; Lu, Dengfu; Gong, Yuefa [Advanced Synthesis and Catalysis, 2018, vol. 360, # 24, p. 4764 - 4773].
[18]Hosseinzadeh, Rahman; Karimi, Samira; Valipour, Zohreh; Aghili, Nora [Organic Preparations and Procedures International, 2024, vol. 56, # 4, p. 307 - 316].
  • 10
  • [ 88-68-6 ]
  • [ 32658-67-6 ]
YieldReaction ConditionsOperation in experiment
95% With iodine; sodium hydrogencarbonate In water at 20℃; 4.1.6. General procedure for preparation of 2-amino-5-iodobenzamide 2e [11] Powdered iodine (11.7 g, 46.2 mmol) was added portion-wise over 1 h to a stirred solution of 2-aminobenzamide 2a (5.72, 42.0 mmol) and NaHCO3 (3.52 g, 42.0 mmol) in water (1.3 l). The solution was stirred overnight at room temperature. Afterward NaHSO3 (0.87 g, 8.40 mmol) was added. The solution was extracted with ethyl acetate (3 x 800 ml). After being dried with Na2SO4, the organic phase was removed under reduced pressure. The crude product was recrystallized with water/methanol (10:1 v/v, 600 ml)to yield pure 2e; yield 95%,
95% With iodine; sodium hydrogencarbonate In water at 20℃; 5 Preparation of 2-amino-5-chlorobenzamide 15b 4.1.5 Preparation of 2-amino-5-iodobenzamide (15c) 21 Powdered iodine (11.7 g, 46.2 mmol) was added portion-wise over 1 h to a stirred solution of 2-aminobenzamide (15a) (5.72, 42.0 mmol) and NaHCO3 (3.52 g, 42.0 mmol) in water (1.3 L). The solution was stirred overnight at room temperature. Afterwards NaHSO3 (0.87 g, 8.40 mmol) was added. The solution was extracted with ethyl acetate (3 * 800 mL). After being dried with Na2SO4, the organic phase was evaporated. The crude product was recrystallized with water/methanol 10:1 v/v (600 mL) to yield pure 15c; yield 95%, mp 197-198 °C.
92% With pyridine; iodine In dichloromethane at 0 - 20℃; for 2h;
89% With dihydrogen peroxide; iodine In water at 50℃; for 24h; 2-Amino-5-iodobenzamide (6b) General procedure: Synthesized in a manneranalogous to [3]. To a suspension containing 2-aminobenzamide (30.0 mmol, 4.1g), I2 (30.0 mmol, 7.6 g), and 150 mL of H2O was added hydrogen peroxide (30wt %, 60.0 mmol, 6.8 mL). This mixture was stirred at 50 °C for 24 h. After that,the reaction was quenched using a concentrated aqueous Na2S2O3 solution andthe mixture was extracted with EtOAc (3 ×). The organic layers were dried withanhydrous MgSO4 and concentrated under reduced pressure. Afterrecrystallization from acetonitrile, compound 6b was obtained in 89% yield as abrown solid (6.99 g, 26.7 mmol); 1H NMR (500 MHz, DMSO-d6, ppm) δ: 7.81 (d,J = 2.0 Hz, 1H), 7.37 (dd, J = 8.7, 2.0 Hz, 1H), 6.54 (d, J = 8.7 Hz, 1H), 3.36 (s,4H); 13C NMR (125 MHz, DMSO-d6, ppm) δ: 169.9, 149.7, 139.8, 136.5, 118.9,116.1, 74.4
88% With N-iodo-succinimide In acetonitrile at 20℃; for 0.5h; 3.2. Synthesis of 2-Amino-5-iodobenzamide (1) A stirred suspension of anthranilamide (1.00 g, 7.34 mmol) in acetonitrile (20 mL) was treated with N-iodosuccinimide (1.65 g, 7.34 mmol) at room temperature. The mixture was stirred at this temperature for 30 min. and then quenched with an ice-cold saturated aqueous solution of sodium thiosulphate. The resultant precipitate was filtered and washed thoroughly with cold water and then recrystallized from ethanol to afford 1 as a white solid (1.69 g, 88%); mp. 198-200 °C (Lit. [18] 197-198 °C); νmax (ATR) 502, 531, 664, 817, 1062, 1228, 1384, 1600, 3162, 3278, 3343 cm-1; δH (500 MHz, DMSO-d6) 6.53 (d,J = 8.5 Hz, 1H), 6.69 (s, 2H), 7.12 (br s, 1H), 7.36 (dd, J = 2.0 and 8.5 Hz, 1H), 7.80 (d, J = 2.0 Hz,1H), 7.81 (br s, 1H); δC (150 MHz, DMSO-d6) 74.8, 116.5, 119.4, 136.9, 140.2, 150.1, 170.3.
85% With N-iodo-succinimide; acetic acid at 20℃; for 1h;
82% With iodine; sodium hydrogencarbonate In water at 20℃; 1 2-Amino-5-iodobenzamide (2)To a stirred solution of 2-aminobenzamide (5.72 g, 42.0 mmol) and NaHCO3 (3.52 g, 42.0 mmol) in water (1.3 I) powdered iodine (11.7 g, 46.2 mmol) was added portionwise in 1 h. The solution was stirred overnight at rt. Afterwards NaHSO3 (0.87 g, 8.40 mmol) was added. The solution was extracted with ethyl acetate (3 x 800 ml). After drying with Na2SO4 the organic phase was removed under reduced pressure. The crude product was recrystallized with water/methanol-mixture (10:1 , v/v, 100 ml) yielding 2 (9.07 g, 34.6 mmol, 82%) as white crystals; mp. 197-198 0C. 1H-NMR (300 MHz, DMSO-de): δ = 6.57 (d, J = 8.7 Hz, 1 H, arom.), 6.74 (s, 2 H, NH2), 7.19 (s, 2 H, CONH2), 7.42 (dd, J = 8.7 Hz, J = 1.8 Hz, 1 H, arom.), 7.84 (d, J = 2.1 Hz, 1 H, arom.). 13C-NMR (75 MHz, DMSO-d6): δ = 74.5, 116.1 , 119.0, 136.5, 139.9, 149.8, 169.9. HR EI-MS: calcd. for (C7H7IN2O): 261.96032, found: 261.95953
82% With iodine; sodium hydrogencarbonate In water at 20℃; for 12h;
75% With 1-butyl-3-methylpyridinium dichloroiodate at 80℃; for 4h; Example 4: General procedure for the iodination of compounds 1 to 18. General procedure: A mixture of aromatic/heteroaromatic amine (1 mmol) and 1-butyl-3-methylpyridinium dichloroiodate (BMPDCI) (1.2 mmol) was heated to 80°C for 1-4 h. After completion of the reaction (monitored by TLC), ethyl acetate was added, followed by addition of water. The organic layer was separated and the aqueous layer was extracted three times with ethyl acetate. The combined organic layer was dried using sodium sulfate and evaporated under vacuum to afford the crude product, which on further column chromatography using silica gel afforded the pure iodinated product as shown in Table 1.
73.8% With iodine; sodium hydrogencarbonate In water at 20℃; for 24h; 1 Step 1: Preparation of 2-amino-5-iodobenzamide The compound 2-aminobenzamide (10.00 g, 73.48 mmol) was dissolved in H2O (250 mL), and sodium bicarbonate (6.17 g, 73.48 mmol) and iodine powder (20.51 g, 80.83 mmol) were sequentially added thereto, Stir at room temperature for 24 hours.TLC spot plate detection, the raw material reaction is completed.The pH of the reaction solution was adjusted to about 7 with sodium bisulfite.After the solid was suction filtered and washed with water, it was dispersed in ethanol and heated to reflux to dissolve.After cooling, it was filtered to obtain the target compound (14.20 g, yield 73.8%) as a lavender solid.
72% With iodine; sodium hydrogencarbonate In water at 60℃; for 19h;
70% With 1,4-dibenzyl-1,4-diazoniabicyclo[2.2.2]octane dichloroiodate; sodium hydrogencarbonate In methanol; dichloromethane at 20℃; for 0.0666667h; regioselective reaction; General procedure for the iodination of aryl amines in solution. General procedure: DBDABCODCI (0.5 mmol)and NaHCO3 (1 mmol) were added to a solution of aryl amine (1 mmol) in CH2Cl2: MeOH(1:1). The reaction mixture was stirred at room temperature for the specified time. Aftercompleting reaction which monitored by TLC, the ethyl acetate added to mixture and filtered,the organic layer washed with 5% aqueous sodium thiosulfate, and dried over MgSO4. Thesolvent was removed in vacuum and the crude mixture was purified by column chromatographyusing ethyl acetate and hexane mixture and analyzed by m.p. and 1H NMR spectroscopy.
63% With iodine; sodium hydrogencarbonate In water at 20℃; for 16h; 7.1 Step 1 : To a suspension of anthranilamide (2.2 g, 16.4 mmol) in an aqueous solution of sodium bicarbonate (5%, 0.1 M, 165 ml.) was added iodine (4.6 g, 18.0 mmol). The reaction mixture was stirred for 16 h at room temperature before being poured into an aqueous saturated solution of sodium sulfite (300 ml.) and extracted with ethyl acetate (3 x 300 ml_). The combined organic extracts were washed with brine (100 ml_), dried over MgS04 and concentrated under vacuum. Purification by flash column chromatography on silica gel using ethyl acetate / cyclohexane as eluent afforded 2- amino-5-iodo-benzamide (2.7 g, 63%) as a beige solid. (0931) 1H-NMR (400 MHz, DMSO): 6.54 (d, J 8.7 Hz, 1 H, Ar); 6.70 (bs, 2H, NH2); 7.13 (bs, 1 H, NH); 7.38 (dd, J 8.7, 2.0 Hz, 1 H, Ar); 7.80 (d, J 2.0 Hz, 1 H, Ar); 7.81 (bs, 1 H, NH). M/Z (M+H)+ = 263.0.
With N-iodo-succinimide; acetic acid at 20℃; for 1h;
With iodine; sodium hydrogencarbonate In water
92 % With pyridine; iodine at 0 - 20℃;

References: [1]Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe [European Journal of Medicinal Chemistry, 2013, vol. 65, p. 427 - 435].
[2]Raffa, Demetrio; Maggio, Benedetta; Plescia, Fabiana; Cascioferro, Stella; Raimondi, Maria Valeria; Cancemi, Gabriella; D'Anneo, Antonella; Lauricella, Marianna; Cusimano, Maria Grazia; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe [Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6305 - 6316].
[3]Zhu, Yan-Ping; Fei, Zhuan; Liu, Mei-Cai; Jia, Feng-Cheng; Wu, An-Xin [Organic Letters, 2013, vol. 15, # 2, p. 378 - 381].
[4]Nishimura, Rodolfo H.V.; Dos Santos, Thiago; Murie, Valter E.; Furtado, Luciana C.; Costa-Lotufo, Leticia V.; Clososki, Giuliano C. [Beilstein Journal of Organic Chemistry, 2021, vol. 17, p. 2968 - 2975].
[5]Mphahlele, Malose Jack; Paumo, Hugues Kamdem; Rhyman, Lydia; Ramasami, Ponnadurai [Molecules, 2015, vol. 20, # 8, p. 14656 - 14683].
[6]Bhargava Reddy, Mandapati; Prasanth, Kesavan; Anandhan, Ramasamy [Organic and Biomolecular Chemistry, 2020, vol. 18, # 47, p. 9601 - 9605].
[7]Current Patent Assignee: LEIPZIG UNIVERSITY - WO2010/81881, 2010, A1 Location in patent: Page/Page column 37.
[8]Rambabu; Kiran Kumar; Yogi Sreenivas; Sandra, Sandhya; Kandale, Ajit; Misra, Parimal; Basaveswara Rao; Pal, Manojit [Tetrahedron Letters, 2013, vol. 54, # 6, p. 495 - 501].
[9]Current Patent Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH IN - WO2016/113757, 2016, A1 Location in patent: Page/Page column 12; 15.
[10]Current Patent Assignee: CHENGDU HYPERWAY PHARMACEUTICALS - WO2022/33420, 2022, A1 Location in patent: Paragraph 30; 31.
[11]McGrory, Rochelle; Faggyas, Réka J.; Sutherland, Andrew [Organic and Biomolecular Chemistry, 2021, vol. 19, # 27, p. 6127 - 6140].
[12]Alikarami, Mohammad; Nazarzadeh, Somayeh; Soleiman-Beigi, Mohammad [Bulletin of the Chemical Society of Ethiopia, 2015, vol. 29, # 1, p. 157 - 162].
[13]Current Patent Assignee: DOMAIN THERAPEUTICS - WO2020/21064, 2020, A1 Location in patent: Page/Page column 124-125.
[14]Mphahlele, Malose Jack; Maluleka, Marole Maria; Rhyman, Lydia; Ramasami, Ponnadurai; Mampa, Richard Mokome [Molecules, 2017, vol. 22, # 1].
[15]Raffa, Demetrio; Plescia, Fabiana; Maggio, Benedetta; Raimondi, Maria Valeria; D'Anneo, Antonella; Lauricella, Marianna; Daidone, Giuseppe [European Journal of Medicinal Chemistry, 2017, vol. 132, p. 262 - 273].
[16]Jayaram, Alageswaran; Govindan, Karthick; Kannan, Vijaya Raghavan; Thavasianandam Seenivasan, Vijay; Chen, Nian-Qi; Lin, Wei-Yu [Journal of Organic Chemistry, 2023, vol. 88, # 3, p. 1749 - 1761].
  • 11
  • [ 619-73-8 ]
  • [ 88-68-6 ]
  • [ 4765-59-7 ]
YieldReaction ConditionsOperation in experiment
93% With 1,10-Phenanthroline; di-tert-butyl peroxide; copper(II) bis(trifluoromethanesulfonate) In chlorobenzene at 110℃; for 12h; Schlenk technique; Sealed tube; General procedure for the synthesis of quinazolinones General procedure: In a 25 mL Schlenk tube equipped with a stir bar was placed 1 (0.5 mmol), 2 (0.6 mmol), Cu(OTf)2 (10 mol%), 1,10-phenanthroline (10 mol%), DTBP (2.0 equiv) and 2 mL PhCl. The mixture was stirred at 110 °C for 12 h. After the reaction was finished, the mixture was cooled to room temperature, then washed with water, and extracted with ethyl acetate. The combined organic phases were dried over anhydrous MgSO4, concentrated in vacuum, and the crude product was purified by column chromatography on silica gel with PE/EtOAc as eluent to afford the pure product 3.
89% With oxygen In dimethyl sulfoxide at 120℃; for 12h; Schlenk technique; Sealed tube; Green chemistry; General procedure for the synthesis of N-heterocyclic compounds General procedure: A 25 mL Schlenk-type tube equipped with a magnetic stir bar was charged with o-substituted aniline 1a-1f. The reaction tube was evacuated and back-filled with O2. Under oxygen atmospheres, ethers or alcohols 2a-2n and DMSO were added at room temperature, then the reaction mixture was stirred at 120 C for 12 h. The reaction was monitored by TLC. After completion of the reaction, the resulting solution was cooled to room temperature, and neutralized with saturated NaHCO3 aqueous solution. The product was extracted with EtOAc or CHCl3, dried over anhydrous Na2SO4 and concentrated in vacuum. The crude product was purified by flash column chromatography on silica gel to give N-heterocyclic compounds 3.
83% With iodine; sodium hydroxide In water at 20℃; for 6h; Electrochemical reaction; Green chemistry;
78% With dipotassium peroxodisulfate In water; acetonitrile at 20℃; for 5h; Electrochemical reaction; Green chemistry;
75% With potassium hydroxide In toluene at 90℃; for 24h; Typical procedure of synthesis of 4(3H)-quinazolinones General procedure: To an oven-dried 20 cm3 test tube with a ground-in stopperequipped with a stir bar were added anthranilamide (1.0 mmol), benzyl alcohol (1.0 mmol), KOH (2.0 mmol),and 4 cm3 toluene. The test tube was put in an oil bath potpreheated at 90 C and the mixture was stirred for 20 h at90 C. After cooling to room temperature, the reactionmixture was added about 5 g silica gel and directly condensedon a rotator under vacuum. The resulting residualwas transferred to a silica gel chromatography column andeluted with a solution of petroleum ether and ethyl acetate[4/1 (v/v)] to give a white solid 2-phenyl-4(3H)-quinazolinone.For some products (3f, 3g, 3n, and 3t) onlysparingly soluble in ethyl acetate, the reaction mixtureswere condensed in vacuo on a rotary evaporator. Theresiduals were washed three times with water and oncewith ethyl acetate, and then dried in an infrared oven togive the desired products pure enough for NMR analysis.
72% With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; potassium hydroxide In toluene at 100℃; for 12h;
68% With tert.-butylhydroperoxide; basolite F300 In dimethyl sulfoxide at 60℃; for 14h;
63% With potassium <i>tert</i>-butylate; C37H30N3OPPd In toluene at 110℃; for 24h;
63% With niobium(V) oxide; potassium hydroxide In water for 24h; Heating;
60% With potassium hydroxide In para-xylene at 80℃; for 6h; General procedure for the preparation of 2-(substituted)quinazolin-4(3H)-ones General procedure: In a two-necked flask, a mixture of o-aminobenzamide(1 mmol, 0.14 g), benzyl alcohol (1 mmol) in the presenceof catalyst: 0.05 g (3.10 mol%) for Fe3O4bagasse; 0.05 g(7.90 mol%) for MnO2bagasse; or 0.05 g for MnO2-Fe3O4bagasse, KOH (0.028 g, 0.5 mmol), and p-xylene (5 mL) wereheated for 6 h under stirring conditions and air blowing at80 °C. The progress of the reaction was monitored by TLC.After completion, the catalyst was separated by an externalmagnet and washed with water. After removing the organicsolvents, and crude product was separated to give final product.
55% With potassium <i>tert</i>-butylate; [Zn(2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline)Cl2]; zinc In toluene at 100℃; for 16h;
52% With C18H11Cl3CuN4; sodium hydroxide In toluene at 90℃; for 36h;
50% With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In 5,5-dimethyl-1,3-cyclohexadiene for 120h; Inert atmosphere; Reflux;
50% With [Ni(MeTAA)]; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 100℃; for 36h; Inert atmosphere; Schlenk technique;
14% With oxygen In dimethyl sulfoxide at 160℃; for 7h; Synthesis of 2-substituted-4(3H)-quinazolinones: 3a-k General procedure: 2-aminobenzamide (1a) (0.5 mmol) and alcohol (2) (2 mmol) were added to an oven-dried glassware with DMSO (1 mL). Then the system was degassed and filled with oxygen. The reaction mixture was stirred and heated to 140°C. Progress of the reactionwas monitored by TLC. After completion of the reaction,the resulting solution was cooled to room temperature, and diluted with dichloromethane, washed with water and brine, dried over anhydrous Na2SO4 and concentrated with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/tetrahydrofuran (5:1 to 2:1) as eluent to provide the desired product.
81 % With iodine In water; dimethyl sulfoxide at 50℃; Sonication;
56 % With iron(III) chloride; tert-butylammonium hexafluorophosphate(V); toluene-4-sulfonic acid In water; acetonitrile at 20℃; Electrolysis; General procedure for the catalytic reactions General procedure: A dried 10 mL quartz tube equipped was charged with o-aminobenzamide (0.5 mmol), benzyl alcohol (1 mmol), FeCl3 (0.1 mmol), TsOH (2.0 equiv.), Bu4NPF6 (1.0 equiv). The mixture was stirred at room temperature with a voltage range of 2-6 V for 8 h with 40 mA (Pt anode (10.0 mm × 10.0 mm), Pt cathode (10.0 mm × 10.0 mm) in H2O/MeCN (v/v1:1)=3.0 ml solvent. After the reaction was completed, the reaction vessel was opened and the organic layer was collected by ethyl acetate extraction. The solution of the crude product was concentrated in vacuo, and the residue was purified by column chromatography on a silica gel (petroleum ether/ethyl acetate=3/1) to afford the target product as a white solid.
56 % With iron(III) chloride; tert-butylammonium hexafluorophosphate(V); toluene-4-sulfonic acid In water; acetonitrile at 20℃; Electrolysis; Green chemistry; General procedure for the catalytic reactions General procedure: A dried 10 mL quartz tube equipped was charged with o-aminobenzamide (0.5 mmol), benzyl alcohol (1 mmol), FeCl3 (0.1 mmol), TsOH (2.0 equiv.), Bu4NPF6 (1.0 equiv). The mixture was stirred at room temperature with a voltage range of 2-6 V for 8 h with 40 mA (Pt anode (10.0 mm × 10.0 mm), Pt cathode (10.0 mm × 10.0 mm) in H2O/MeCN (v/v1:1)=3.0 ml solvent. After the reaction was completed, the reaction vessel was opened and the organic layer was collected by ethyl acetate extraction. The solution of the crude product was concentrated in vacuo, and the residue was purified by column chromatography on a silica gel (petroleum ether/ethyl acetate=3/1) to afford the target product as a white solid.
80 % With potassium iodide; sodium hydroxide In water at 20℃; 2. General procedure for the catalytic reactions General procedure: A stirred mixture of 2-aminobenzamide (0.5 mmol) and benzyl alcohol (0.8 mmol) in water (2 mL) was treated using KI (0.2 mmol) as the catalyst, and NaOH (2 mmol) as the base. The reaction mixture was stirred under sunlight at room temperature for 8 h until the starting material disappeared (monitored by TLC6-12 h). The reaction solution was dissolved in ethyl acetate (15 mL), followed by the addition of saturated brine (15 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (15 mL × 2). The combined organic extracts were dried over anhydrous Na2SO4, filtered, concentrated, and purified through silica gel column chromatography using a mixture of ethyl acetate (EtOAc) and petroleum ether (PE) as eluent to afford the pure corresponding product.
70 % With potassium <i>tert</i>-butylate In toluene at 110℃; Sealed tube; 2.5. General procedure for the synthesis of 2-substituted quinazolinones General procedure: By insight from the previous reports [74,75], inside the sealed tube, amixture of 2-aminobenzamide (1 mmol), benzyl alcohol (1 mmol), andt-BuOK (1 mmol, 0.112 g) along with MWCNTPy-Ni(0) (1.4 mgequivalent to 5 mol% Ni) as a catalyst was subjected to reflux in thepresence of toluene (1.5 mL) at a temperature of 110C for 8 h. TLC wasused to check the reaction’s progress, and once the reaction ended, thecatalyst was separated from the reaction mixture by centrifugation.Then the catalyst was washed well with EtOAc (2 × 5 mL) and then DIH2O (2 × 5 mL) the catalyst was dried at 70C overnight for the next run.The product was extracted with CHCl3 and then purified using a plate(40:1 CHCl3/MeOH). The structure of the synthesized quinazolinoneswas identified and proved by measuring the melting point and by FT-IR,Mass, 1HNMR, and 13CNMR analyses.

References: [1]Li, Jin; Cao, Haotian; Tian, Hongyou; Li, Huaju; Hu, Yongke [Synthetic Communications, 2025, vol. 55, # 10, p. 774 - 782].
[2]Chen, Xiuling; Qi, Hongxue; Wu, Shaofeng; Liu, Leng; Wen, Jianhui; Li, Wanxi; Guo, Fang; Bian, Yongjun; Li, Jun [Heterocycles, 2017, vol. 94, # 1, p. 86 - 94].
[3]Hou, Huiqing; Ma, Xinhua; Lin, Yingying; Lin, Jin; Sun, Weiming; Wang, Lei; Xu, Xiuzhi; Ke, Fang [RSC Advances, 2021, vol. 11, # 29, p. 17721 - 17726].
[4]Hu, Yongzhi; Hou, Huiqing; Yu, Ling; Zhou, Sunying; Wu, Xianghua; Sun, Weiming; Ke, Fang [RSC Advances, 2021, vol. 11, # 50, p. 31650 - 31655].
[5]Qiu, Dezhi; Wang, Yanyan; Lu, Dongming; Zhou, Lihong; Zeng, Qingle [Monatshefte fur Chemie, 2015, vol. 146, # 8, p. 1343 - 1347].
[6]Hu, Yongke; Chen, Lei; Li, Bindong [RSC Advances, 2016, vol. 6, # 69, p. 65196 - 65204].
[7]Oveisi, Ali Reza; Khorramabadi-Zad, Ahmad; Daliran, Saba [RSC Advances, 2016, vol. 6, # 2, p. 1136 - 1142].
[8]Anandaraj, Pennamuthiriyan; Ramesh, Rengan; Kamatchi, Thangavel Sathiya [Inorganic Chemistry Communications, 2022, vol. 137].
[9]Deepak, Rajasekharan Jayakumari; Pavin, Thiagu; Karvembu, Ramasamy [Dalton Transactions, 2025, vol. 54, # 26, p. 10318 - 10326].
[10]Rashidi Vahid, Adina; Hajishaabanha, Fatemeh; Shaabani, Shabnam; Farhid, Hassan; Shaabani, Ahmad [Journal of the Iranian Chemical Society, 2022, vol. 19, # 6, p. 2601 - 2615].
[11]Das, Siuli; Mondal, Rakesh; Chakraborty, Gargi; Guin, Amit Kumar; Das, Abhishek; Paul, Nanda D. [ACS Catalysis, 2021, vol. 11, # 12, p. 7498 - 7512].
[12]Das, Siuli; Sinha, Suman; Samanta, Deepannita; Mondal, Rakesh; Chakraborty, Gargi; Brandaõ, Paula; Paul, Nanda D. [Journal of Organic Chemistry, 2019, vol. 84, # 16, p. 10160 - 10171].
[13]Zhou, Jianguang; Fang, Jie [Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 7730 - 7736].
[14]Parua, Seuli; Das, Siuli; Sikari, Rina; Sinha, Suman; Paul, Nanda D. [Journal of Organic Chemistry, 2017, vol. 82, # 14, p. 7165 - 7175].
[15]Wang, Zhen-Zhen; Tang, Yu [Tetrahedron, 2016, vol. 72, # 10, p. 1330 - 1336].
[16]Ramarao, Sidda; Pothireddy, Mohanreddy; Venkateshwarlu, Rapolu; Moturu, Krishna Murthy VR.; Siddaiah, Vidavalur; Kapavarapu, Ravikumar; Dandela, Rambabu; Pal, Manojit [Journal of Molecular Structure, 2023, vol. 1273].
[17]Wu, Bin; Duan, Qixin; Chen, Fengyuan; Xu, Yingying; Zhang, Qi; Xu, Xiuzhi; Lin, Jin [Tetrahedron, 2023, vol. 143].
[18]Wu, Bin; Duan, Qixin; Chen, Fengyuan; Xu, Yingying; Zhang, Qi; Xu, Xiuzhi; Lin, Jin [Tetrahedron, 2023, vol. 143].
[19]Chen, Taiping; Yang, Huan; Li, Shuangjun; Xie, Jiangping; Wei, Lingyu; Yang, Li [Tetrahedron Letters, 2023, vol. 131].
[20]Mirzaeian, Fatemeh; Sabet-Sarvestani, Hossein; Eshghi, Hossein [Journal of Molecular Structure, 2025, vol. 1319].
  • 12
  • [ 636-72-6 ]
  • [ 88-68-6 ]
  • [ 26059-85-8 ]
YieldReaction ConditionsOperation in experiment
86% With tert.-butylhydroperoxide In dimethyl sulfoxide at 25 - 35℃; for 40h; Irradiation; Green chemistry; 1. General information. General experimental procedure for the synthesis of quinazolinones: General procedure: a 10-mL glass tube was filled with the required 2-aminobenzamide (0.2 mmol), alcohol (0.5 mmol), and TBHP (1 equiv.) and irradiated at room temperature with an 18 W blue LED for 40 h. After reaction completion (monitored by TLC), water was added to the reaction solution and the mixture was extracted with EtOAc. The combined organic layers were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by silica-gel column chromatography using petroleum ether/ethyl acetate as eluent to give the desired product.
81% With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; potassium hydroxide In toluene at 100℃; for 12h;
81% With potassium <i>tert</i>-butylate; [Zn(2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline)Cl2]; zinc In toluene at 100℃; for 16h;
78% With iodine; sodium hydroxide In water at 20℃; for 6h; Electrochemical reaction; Green chemistry;
78% With potassium <i>tert</i>-butylate; oxygen; C26H20N2S2 In toluene at 20℃; for 15h; Irradiation;
77% With oxygen In dimethyl sulfoxide at 120℃; for 12h; Schlenk technique; Sealed tube; Green chemistry; General procedure for the synthesis of N-heterocyclic compounds General procedure: A 25 mL Schlenk-type tube equipped with a magnetic stir bar was charged with o-substituted aniline 1a-1f. The reaction tube was evacuated and back-filled with O2. Under oxygen atmospheres, ethers or alcohols 2a-2n and DMSO were added at room temperature, then the reaction mixture was stirred at 120 C for 12 h. The reaction was monitored by TLC. After completion of the reaction, the resulting solution was cooled to room temperature, and neutralized with saturated NaHCO3 aqueous solution. The product was extracted with EtOAc or CHCl3, dried over anhydrous Na2SO4 and concentrated in vacuum. The crude product was purified by flash column chromatography on silica gel to give N-heterocyclic compounds 3.
75% With HBEA zeolite supported Pt metal nanocluster In 1,3,5-trimethyl-benzene at 165℃; for 24h; Inert atmosphere;
75% With potassium <i>tert</i>-butylate; oxygen; [Fe(L1)Cl2] In toluene at 110℃; for 36h; 4.4. Procedure for substituted quinazolin-4(3H)-ones synthesis General procedure: To an oven-dried 20.0 mL round bottom flask containing a magnetic stir bar, a mixture of catalyst 1 (4.0 mol%), tBuOK (0.5equiv.), alcohol (1.1 mmol), and 2-aminobenzamide (1.0 mmol) were added under air. To it, 5.0 mL dry toluene was added by syringe. The reaction vessel was then fitted with a water condenser and allowed to stir at 110 °C for 36 h, under air. The reaction was monitored by TLC. After the reaction was complete, the resulting mixture was concentrated under vacuum using a rotary vacuume vaporator and purified by silica gel column chromatography using petroleum ether/ethyl acetate (3:1).
74% With styrene; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] In 5,5-dimethyl-1,3-cyclohexadiene for 48h; Inert atmosphere; Reflux;
73% With potassium <i>tert</i>-butylate; trans-[Ru-(NpL)(CO)Cl(triphenylphosphine)2], In toluene at 85℃; for 6h;
72% With tert.-butylhydroperoxide; zinc(II) iodide In water; dimethyl sulfoxide at 110℃; for 16h;
68% With C18H11Cl3CuN4; sodium hydroxide In toluene at 90℃; for 36h;
68% With C18H11Cl3CoN4; sodium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene at 120℃; for 30h;
68% With potassium <i>tert</i>-butylate In neat (no solvent) at 140℃; for 24h; Schlenk technique; Inert atmosphere;
67% With styrene; [Ni(MeTAA)]; sodium t-butanolate In 5,5-dimethyl-1,3-cyclohexadiene at 100℃; for 36h; Inert atmosphere; Schlenk technique;
65% With caesium carbonate In neat (no solvent) at 150℃; for 24h; Inert atmosphere; One-pot synthesis of 2-phenyl quinazolinone via acceptorless dehydrogenation using Ni NPs (at)N-Ccatalyst General procedure: 2-aminobenzamide (0.50 mmol), benzyl alcohol (1.5 mmol), Cs2CO3 (0.1 mmol, 20 mol %) and Ni NPs (at)N-C (10 mg, Ni content: 0. 252 wt %) were charged in an oven-dried reaction vessel, flushed with argongas and maintained the inert atmosphere using an argon balloon. The reaction was carried out on a preheatedheating block (heating block temperature 150 °C) and stirred for 24 h (monitored by TLC). After thecompletion of the reaction, the reaction mixture was quenched with ethyl acetate (EtOAc) and filtered through a celite bed, the filtrate was evaporated to dryness using a rotary evaporator to obtain the crudeproduct. The crude product was further purified by column chromatography using an EtOAc-hexanesolvent mixture (10:90). The same procedure was followed for all other substrates in Table 2.
61% With potassium <i>tert</i>-butylate; C37H30N3OPPd In toluene at 110℃; for 24h;
61% With niobium(V) oxide; potassium hydroxide In water for 24h; Heating;
55% With 1,10-Phenanthroline; di-tert-butyl peroxide; copper(II) bis(trifluoromethanesulfonate) In chlorobenzene at 110℃; for 12h; Schlenk technique; Sealed tube; General procedure for the synthesis of quinazolinones General procedure: In a 25 mL Schlenk tube equipped with a stir bar was placed 1 (0.5 mmol), 2 (0.6 mmol), Cu(OTf)2 (10 mol%), 1,10-phenanthroline (10 mol%), DTBP (2.0 equiv) and 2 mL PhCl. The mixture was stirred at 110 °C for 12 h. After the reaction was finished, the mixture was cooled to room temperature, then washed with water, and extracted with ethyl acetate. The combined organic phases were dried over anhydrous MgSO4, concentrated in vacuum, and the crude product was purified by column chromatography on silica gel with PE/EtOAc as eluent to afford the pure product 3.
46% With carbon tetrabromide; fluorescein free acid In 1,4-dioxane at 20℃; for 12h; Irradiation; Synthesis of quinazolinones derivatives A mixture of 2-aminobenzamide (0.1 mmol), benzyl alcohol (0.25mmol), CBr4 (5 mol%) and fluorescein (5 mol%) in MeOH (1.5 mL) wasadded to a test tube. The mixture was then irradiated with a blue LED(18 W) for 12 h in air and stirred at a rotational speed of 300-400 rpm.The reaction was monitored using thin-layer chromatography (petroleumether: ethyl acetate = 4:1, v/v). The organic phase was concentratedunder reduced pressure to obtain the crude product, which wassubsequently purified using column chromatography (petroleum ether:ethyl acetate= 2:1, v/v) to obtain the pure product
42% With sulphur; potassium <i>tert</i>-butylate; dimethyl sulfoxide at 140℃; for 16h; Inert atmosphere; 2.1. General Procedure General procedure: A mixture of 2-aminobenzamides 1 (0.5 mmol), aryl alcohols 2 (0.75 mmol), sulfur (2.5mmol, 80 mg), KOtBu (1 mmol, 112.2 mg), and DMSO (3.5 mL) in a 7 mL glass test tube,under an argon atmosphere, was heated at 140 °C for 16 h. The reaction mixture waspurified by column chromatography on silica gel with the eluting solvent being EtOAc/nhexanefrom 8% to 30%, v/v.
88 %Chromat. With tert.-butylhydroperoxide; manganese dioxide In chlorobenzene at 80℃; for 16h;
79 % With iodine In water; dimethyl sulfoxide at 50℃; Sonication;
80.0 % With 9-fluorenone; toluene-4-sulfonic acid In dimethyl sulfoxide; acetonitrile Irradiation; 9 2-(Thiophen-2-yl)quinazolin-4(3H)-one Anthranilamide (27.2mg, 0.2mmol), thiophene-2-methanol (27.4mg, 0.24mmol), 9-fluorenone (1.8mg, 5mol%), p-toluenesulfonic acid (3.4mg, 10mol%) ) and 2 mL of solvent (acetonitrile: DMSO volume ratio 9:1) were added to a 15 mL reaction tube. The reaction mixture was reacted under the irradiation of 10w blue light for 16h. After the reaction, 100mL of water was added to the reaction solution, extracted with ethyl acetate (3×50mL), dried with anhydrous MgSO4, filtered, and the solvent was removed by rotary evaporation, and then passed through the column layer Analysis (developing solvent: petroleum ether/ethyl acetate volume ratio = 10:1) gave the pure target compound as a white solid (36.5mg), yield: 80.0%.
63 % With iron(III) chloride; tert-butylammonium hexafluorophosphate(V); toluene-4-sulfonic acid In water; acetonitrile at 20℃; Electrolysis; General procedure for the catalytic reactions General procedure: A dried 10 mL quartz tube equipped was charged with o-aminobenzamide (0.5 mmol), benzyl alcohol (1 mmol), FeCl3 (0.1 mmol), TsOH (2.0 equiv.), Bu4NPF6 (1.0 equiv). The mixture was stirred at room temperature with a voltage range of 2-6 V for 8 h with 40 mA (Pt anode (10.0 mm × 10.0 mm), Pt cathode (10.0 mm × 10.0 mm) in H2O/MeCN (v/v1:1)=3.0 ml solvent. After the reaction was completed, the reaction vessel was opened and the organic layer was collected by ethyl acetate extraction. The solution of the crude product was concentrated in vacuo, and the residue was purified by column chromatography on a silica gel (petroleum ether/ethyl acetate=3/1) to afford the target product as a white solid.
63 % With iron(III) chloride; tert-butylammonium hexafluorophosphate(V); toluene-4-sulfonic acid In water; acetonitrile at 20℃; Electrolysis; Green chemistry; General procedure for the catalytic reactions General procedure: A dried 10 mL quartz tube equipped was charged with o-aminobenzamide (0.5 mmol), benzyl alcohol (1 mmol), FeCl3 (0.1 mmol), TsOH (2.0 equiv.), Bu4NPF6 (1.0 equiv). The mixture was stirred at room temperature with a voltage range of 2-6 V for 8 h with 40 mA (Pt anode (10.0 mm × 10.0 mm), Pt cathode (10.0 mm × 10.0 mm) in H2O/MeCN (v/v1:1)=3.0 ml solvent. After the reaction was completed, the reaction vessel was opened and the organic layer was collected by ethyl acetate extraction. The solution of the crude product was concentrated in vacuo, and the residue was purified by column chromatography on a silica gel (petroleum ether/ethyl acetate=3/1) to afford the target product as a white solid.
73 % With potassium iodide; sodium hydroxide In water at 20℃; 2. General procedure for the catalytic reactions General procedure: A stirred mixture of 2-aminobenzamide (0.5 mmol) and benzyl alcohol (0.8 mmol) in water (2 mL) was treated using KI (0.2 mmol) as the catalyst, and NaOH (2 mmol) as the base. The reaction mixture was stirred under sunlight at room temperature for 8 h until the starting material disappeared (monitored by TLC6-12 h). The reaction solution was dissolved in ethyl acetate (15 mL), followed by the addition of saturated brine (15 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (15 mL × 2). The combined organic extracts were dried over anhydrous Na2SO4, filtered, concentrated, and purified through silica gel column chromatography using a mixture of ethyl acetate (EtOAc) and petroleum ether (PE) as eluent to afford the pure corresponding product.
81 % With 1,4-bis(4'-pyridyl-1'-pyridinio)phthalazine dichloride In ethanol; water; acetonitrile at 20℃; Schlenk technique; Irradiation; Green chemistry;
64 % With cetyltributylphosphonium bromide; [Mn(2-(1H-pyrazol-1-yl)-1,10-phenanthroline)(H2O)2Cl](Cl); sodium hydroxide In water at 140℃; Sealed tube; Autoclave; High pressure;
78 % With iron(III) chloride In acetonitrile at 20℃; Irradiation;

References: [1]Xie, Zongbo; Lan, Jin; Zhu, Haibo; Lei, Gaoyi; Jiang, Guofang; Le, Zhanggao [Chinese Chemical Letters, 2021, vol. 32, # 4, p. 1427 - 1431].
[2]Hu, Yongke; Chen, Lei; Li, Bindong [RSC Advances, 2016, vol. 6, # 69, p. 65196 - 65204].
[3]Das, Siuli; Mondal, Rakesh; Chakraborty, Gargi; Guin, Amit Kumar; Das, Abhishek; Paul, Nanda D. [ACS Catalysis, 2021, vol. 11, # 12, p. 7498 - 7512].
[4]Hou, Huiqing; Ma, Xinhua; Lin, Yingying; Lin, Jin; Sun, Weiming; Wang, Lei; Xu, Xiuzhi; Ke, Fang [RSC Advances, 2021, vol. 11, # 29, p. 17721 - 17726].
[5]Paramanik, Krishnendu; Bandopadhyay, Nilaj; Mangal, Agnishwar; Pal, Sourabh; Agrawalla, Suraj Kumar; Purohit, Chandra Shekhar; Biswas, Bhaskar; Ahmed, Jasimuddin; Das, Hari Sankar [ChemSusChem, 2025, vol. 18, # 22].
[6]Chen, Xiuling; Qi, Hongxue; Wu, Shaofeng; Liu, Leng; Wen, Jianhui; Li, Wanxi; Guo, Fang; Bian, Yongjun; Li, Jun [Heterocycles, 2017, vol. 94, # 1, p. 86 - 94].
[7]Hakim Siddiki; Kon, Kenichi; Touchy, Abeda Sultana; Shimizu, Ken-Ichi [Catalysis science and technology, 2014, vol. 4, # 6, p. 1716 - 1719].
[8]Mondal, Rakesh; Chakraborty, Gargi; Guin, Amit Kumar; Pal, Subhasree; Paul, Nanda D. [Tetrahedron, 2021, vol. 100].
[9]Zhou, Jianguang; Fang, Jie [Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 7730 - 7736].
[10]Halder, Supriyo; Naskar, Srijita; Jana, Debashis; Kanrar, Gopal; Mandal, Shyama Charan; Roy, Subhadip; Bharadwaj, Nishchal; Pramanik, Kausikisankar; Ganguly, Sanjib [Chemistry - An Asian Journal, 2025, vol. 20, # 4].
[11]Sharif, Muhammad; Opalach, Julita; Langer, Peter; Beller, Matthias; Wu, Xiao-Feng [RSC Advances, 2014, vol. 4, # 1, p. 8 - 17].
[12]Das, Siuli; Sinha, Suman; Samanta, Deepannita; Mondal, Rakesh; Chakraborty, Gargi; Brandaõ, Paula; Paul, Nanda D. [Journal of Organic Chemistry, 2019, vol. 84, # 16, p. 10160 - 10171].
[13]Sinha, Suman; Das, Siuli; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D. [Dalton Transactions, 2020, vol. 49, # 25, p. 8448 - 8459].
[14]Sardar, Bitan; Jamatia, Ramen; Samanta, Arup; Srimani, Dipankar [Journal of Organic Chemistry, 2022, vol. 87, # 9, p. 5556 - 5567].
[15]Parua, Seuli; Das, Siuli; Sikari, Rina; Sinha, Suman; Paul, Nanda D. [Journal of Organic Chemistry, 2017, vol. 82, # 14, p. 7165 - 7175].
[16]Vageesh; Patil, Omkar; Hima; Dey, Raju [Synlett, 2024, vol. 35, # 20, p. 2496 - 2502].
[17]Anandaraj, Pennamuthiriyan; Ramesh, Rengan; Kamatchi, Thangavel Sathiya [Inorganic Chemistry Communications, 2022, vol. 137].
[18]Deepak, Rajasekharan Jayakumari; Pavin, Thiagu; Karvembu, Ramasamy [Dalton Transactions, 2025, vol. 54, # 26, p. 10318 - 10326].
[19]Li, Jin; Cao, Haotian; Tian, Hongyou; Li, Huaju; Hu, Yongke [Synthetic Communications, 2025, vol. 55, # 10, p. 774 - 782].
[20]Jiang, Guofang; Wang, Aixin; Huang, Sheng; Xie, Zongbo; Le, Zhanggao [Molecular Catalysis, 2026, vol. 588].
[21]Vo, Ngoc Binh; Nguyen, Le Thanh Hang; Nguyen, Le Anh; Le, Dang Quang; Ngo, Quoc Anh [Synlett, 2025].
[22]Zhang, Zhe; Wang, Min; Zhang, Chaofeng; Zhang, Zhixin; Lu, Jianmin; Wang, Feng [Chemical Communications, 2015, vol. 51, # 44, p. 9205 - 9207].
[23]Ramarao, Sidda; Pothireddy, Mohanreddy; Venkateshwarlu, Rapolu; Moturu, Krishna Murthy VR.; Siddaiah, Vidavalur; Kapavarapu, Ravikumar; Dandela, Rambabu; Pal, Manojit [Journal of Molecular Structure, 2023, vol. 1273].
[24]Current Patent Assignee: SHANGHAI XIANGSHI CHEMICAL - CN115650924, 2023, A Location in patent: Paragraph 0074-0078.
[25]Wu, Bin; Duan, Qixin; Chen, Fengyuan; Xu, Yingying; Zhang, Qi; Xu, Xiuzhi; Lin, Jin [Tetrahedron, 2023, vol. 143].
[26]Wu, Bin; Duan, Qixin; Chen, Fengyuan; Xu, Yingying; Zhang, Qi; Xu, Xiuzhi; Lin, Jin [Tetrahedron, 2023, vol. 143].
[27]Chen, Taiping; Yang, Huan; Li, Shuangjun; Xie, Jiangping; Wei, Lingyu; Yang, Li [Tetrahedron Letters, 2023, vol. 131].
[28]Yao, Xin-Rong; Jia, Meng-Ze; Miao, Xiao-Li; Chen, Yun-Rui; Pan, Jia-Qi; Zhang, Jie [ChemSusChem, 2024, vol. 17, # 7].
[29]Mondal, Sucheta; Chakraborty, Subhajit; Khanra, Subhankar; Chakraborty, Santana; Pal, Shrestha; Brandão, Paula; Paul, Nanda D. [Journal of Organic Chemistry, 2024, vol. 89, # 8, p. 5250 - 5265].
[30]Pan, Xin-Yao; Sun, Gui-Xia; Huang, Fang-Ping; Qin, Wen-Jian; Teng, Qing-Hu; Wang, Kai [Organic and Biomolecular Chemistry, 2024, vol. 22, # 15, p. 2968 - 2973].
  • 13
  • [ 66-77-3 ]
  • [ 88-68-6 ]
  • [ 31785-60-1 ]
YieldReaction ConditionsOperation in experiment
96% With sulfonic acid functionalized L-Proline-Fe3O4 nanoparticles In ethanol at 50℃; for 0.25h; Green chemistry; General procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones: (3a-p) General procedure: In 10 mL of ethanol, a mixture of 2-aminobenzamide (1 mmol) and an aromatic aldehyde (1 mmol) were added in a round-bottom flask with 0.010 g of Fe3O4L-proline sulfonic acid as a catalyst. The reaction mixture was stirred at 50 oC with an appropriate time and was monitored by thin-layer chromatography (TLC). When the reaction mixture was completed, the catalyst was recovered using an external magnet and then used for the next five runs. The product obtained was filtered and re-crystallized from hot ethanol.
89% With LACTIC ACID In neat (no solvent) at 70℃; for 0.916667h; Green chemistry; General procedure for synthesis of 2,3-dihydroquinazolin-4(1H)-ones Method A: General procedure: 2-Aminobenzamide (1 mmol, 0.136 g) was added to a mixture of aldehyde (1.2 mmol) and lactic acid (0.02 mmol, 0.018 g) and stirred at 70 C. After reaction completion (as monitored by TLC), ethanol (5 ml) was added and stirred vigorously. Filtration of the resulting suspension afforded solid products.
87% With phosphotungstic acid In neat (no solvent) at 100℃; for 0.05h; Microwave irradiation; Green chemistry; 2.1 General experimental procedure for synthesis of Cyclic and Spiro Quinazolinones (3a-3n, 4a-h) and 5a, 5b, 6a, 7a General procedure: O-amino amides 1a-e (1 equiv.) and carbonyl compounds 2a-o (1.2 equiv.) were microwave irradiated (standard mode) in the presence of Phosphotungstic acid/HPW (50 % w/w) at 200 W for 3 min. After the completion of the reaction (Monitored by TLC), HPW was filtered off using celite bed/Silica bed. The crude product was purified on silica gel a column chromatography to afford the corresponding spiro and cyclic quinazolinones 3a-3n, 4a-4h, and 5a, 5b in very good yields except compounds 6a and 7a were obtained in poor yields (Eluent: n-Hexane /EtOAc). All the compounds 3a-3n, 4a-4h, 5a-b, 6a and 7a were thoroughly characterized by 1H NMR, 13CNMR, FTIR and HRMS.
84% With [Ce((L)-proline)2]2(oxalate) In ethanol at 50 - 55℃; Green chemistry; General experimental procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using [Ce(L-Pro)2]2 (Oxa) General procedure: Catalyst (5 mol %) was dissolved in EtOH (10 mL), added anthranilamide (1.0 mmol), andbenzaldehyde (1.0 mmol) to it. The reaction mixture was heated at 50-55 oC until completion ofthe reaction as indicated by TLC. The reaction mixture was cooled to rt, and separate catalystfrom the reaction mixture then the solvent was evaporated under reduced pressure. Further,the crude product was purified by recrystallization by using EtOH (Table 1, 3a, 3g, 3h, 3i, 3j and3k), and a few compounds were purified by column chromatography by using EtOAc andhexane mixture as an eluent (3:7). The identity and purity of the product were confirmed by 1H,13C NMR, IR and mass spectra.
83% With β-cyclodextrin In water at 55 - 60℃; Neutral conditions; Green chemistry; General experimental procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using β-cyclodextrin General procedure: β-Cyclodextrin (10 mol %) was dissolved in water (15 ml), and to this clear solution, benzaldehyde (1.0 mmol) was added, and stirred for 15 min, followed by the addition of anthranilamide (1.0 mmol). The reaction mixture was heated at 55-60 0C until completion of the reaction as indicated by TLC. The reaction mixture was cooled to 5 0C and β-cyclodextrin was filtered. The aqueous layer was extracted with ethyl acetate (4 x 10 ml). The combined organic layers were washed with water, saturated brine solution, and dried over anhydrous Na2SO4. The combined organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethyl acetate and hexane mixture (3:7) as an eluent. The identity and purity of the product were confirmed by 1H, 13C NMR, and mass spectra.
75% With Amberlyst-15 In acetonitrile at 20℃; for 1h;
60.8% With aminosulfonic acid In methanol at 20℃; for 0.5h;
30% With tin(ll) chloride In ethanol at 120℃; for 0.333333h; Microwave irradiation; Green chemistry; 2-Phenyl-2,3-dihydroquinazolin-4(1H)-one (10a) General procedure: To a microwave vial containing 2-aminobenzamide (8; 226 mg,1.66 mmol), benzaldehyde (9a; 0.17mL, 1.73 mmol, 1.1 equiv.) and tin(II) chloride (3 mg, 0.015 mmol, 0.01 equiv.) were added and stirred in ethanol (3mL) to form a suspension. The microwave vial was then irradiated at 120°C for 20 min. The resultant precipitate was then collected by filtration and washed with minimal H2O (or diethyl ether), affording 2-phenyl-2,3-dihydroquinazolin-4(1H)-one as a white crystalline solid (298 mg, 80%).
In water for 2h; Reflux; 14 2-(naphthalen-1-yl)quinazolin-4(3Η)-one Aminobenzamide (136 mg, lmmol), 1-naphthalene formaldehyde (156 mg, lmmol), Water (1. OmL) In turn addTo a 5 mL single-necked flask. The mixture was reacted at reflux temperature for 2 hours and then cooled to room temperature. Then add [Cp * Ir (H20) 3][0Tf] 2 (6.8 mg, 0. ol mmol, 1 mol%), reacted at reflux temperature for 1 hour, and then cooled to room temperature. Vacuum removed under pressureThe solvent was then passed through a column chromatography (developing solvent): Ethyl acetate / n-hexane) to give the pure title compound,Yield: 85%.
With low transition temperature mixture (LTTM) containing SnCl2 and L-proline In neat (no solvent) at 80℃; for 0.5h; Green chemistry; General procedure for synthesis of 3a-n and 6a-n: General procedure: For two component condensation, a mixture of anthranilamide (1 mmol), LTTM (5 mL) and appropriate aldehyde (1 mmol) was stirred at 80 °C for 30 min. For three component condensation a mixture of isatoic anhydride (1 mmol), LTTM (5 mL) and ammonium acetate (1.3 mmol) in reaction tube was stirred at 80 °C for 5 min and then appropriate aldehyde (1 mmol) was added in reaction tube at 80 °C for 30 min. The progress of the reaction was monitored by thin-layer chromatography (TLC). After completion, distilled water (15 mL) was added and the mixture was stirred for 2 min. The corresponding solid product was obtained through simple filtration, which was recrystallized from absolute ethanol (Scheme-I).
89 % With alginic acid In water at 20℃; Green chemistry; General procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones General procedure: A mixture of anthranilamide (1 mmol), aldehyde/ketone (1 mmol), and alginic acid(5 mg) in water (5 mL) was stirred at room temperature. Reaction progress wasmonitored by TLC (ethyl acetate: n-hexane, 1:9). After completion of the reaction,0.1 N NaOH (5 mL) was added to the reaction mixture to separate alginic acid assodium alginate. The resultant solid product was collected by simple filtration andwashed with water (5 mL). This crude product was recrystallized by using ethanol.

References: [1]Kharmawlong, George Kupar; Nongrum, Ridaphun; Chhetri, Bhusan; Rani, Jims World Star; Rahman, Noimur; Yadav, Arun Kumar; Nongkhlaw, Rishanlang [Synthetic Communications, 2019, vol. 49, # 20, p. 2683 - 2695].
[2]Zhaleh, Sara; Hazeri, Nourallah; Maghsoodlou, Malek Taher [Research on Chemical Intermediates, 2016, vol. 42, # 7, p. 6381 - 6390].
[3]Novanna, Motakatla; Kannadasan, Sathananthan; Shanmugam, Ponnusamy [Tetrahedron Letters, 2019, vol. 60, # 2, p. 201 - 206].
[4]Katla, Ramesh; Chowrasia, Rakhi; Da Silva, Caren D. G.; De Oliveira, Aline R.; Dos Santos, Beatriz F.; Domingues, Nelson L. C. [Synthesis, 2017, vol. 49, # 23, p. 5143 - 5148].
[5]Ramesh; Karnakar; Satish; Anil Kumar; Nageswar [Tetrahedron Letters, 2012, vol. 53, # 51, p. 6936 - 6939].
[6]Bharate, Sandip B.; Mupparapu, Nagaraju; Manda, Sudhakar; Bharate, Jaideep B.; Mudududdla, Ramesh; Yadav, Rammohan R.; Vishwakarma, Ram A. [ARKIVOC, 2012, vol. 2012, # 8, p. 308 - 318].
[7]Kang, Yong Jung; Jang, Jung Yoon; Kwon, Young Hoon; Lee, Jun Ho; Lee, Sanggwon; Park, Yujin; Jung, Young-Suk; Im, Eunok; Moon, Hyung Ryong; Chung, Hae Young; Kim, Nam Deuk [International Journal of Molecular Sciences, 2022, vol. 23, # 3].
[8]O'brien, Nicholas S.; McCluskey, Adam [Australian Journal of Chemistry, 2020, vol. 73, # 12, p. 1176 - 1186].
[9]Current Patent Assignee: NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY - CN106518789, 2017, A Location in patent: Paragraph 0097-0100.
[10]Desai; Birajdar; Patil; Kupwade; Deshmukh [Asian Journal of Chemistry, 2022, vol. 34, # 7, p. 1886 - 1892].
[11]Rajmane, Archana; Jadhav, Dipti; Bagade, Kiran; Patil, Suresh; Kumbhar, Arjun [Research on Chemical Intermediates, 2023, vol. 49, # 12, p. 5237 - 5253].
  • 14
  • [ 487-89-8 ]
  • [ 88-68-6 ]
  • [ 396098-84-3 ]
YieldReaction ConditionsOperation in experiment
80% With β-cyclodextrin In water at 55 - 60℃; Neutral conditions; Green chemistry; General experimental procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using β-cyclodextrin General procedure: β-Cyclodextrin (10 mol %) was dissolved in water (15 ml), and to this clear solution, benzaldehyde (1.0 mmol) was added, and stirred for 15 min, followed by the addition of anthranilamide (1.0 mmol). The reaction mixture was heated at 55-60 0C until completion of the reaction as indicated by TLC. The reaction mixture was cooled to 5 0C and β-cyclodextrin was filtered. The aqueous layer was extracted with ethyl acetate (4 x 10 ml). The combined organic layers were washed with water, saturated brine solution, and dried over anhydrous Na2SO4. The combined organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethyl acetate and hexane mixture (3:7) as an eluent. The identity and purity of the product were confirmed by 1H, 13C NMR, and mass spectra.
75% With phosphotungstic acid In neat (no solvent) at 100℃; for 0.05h; Microwave irradiation; Green chemistry; 2.1 General experimental procedure for synthesis of Cyclic and Spiro Quinazolinones (3a-3n, 4a-h) and 5a, 5b, 6a, 7a General procedure: O-amino amides 1a-e (1 equiv.) and carbonyl compounds 2a-o (1.2 equiv.) were microwave irradiated (standard mode) in the presence of Phosphotungstic acid/HPW (50 % w/w) at 200 W for 3 min. After the completion of the reaction (Monitored by TLC), HPW was filtered off using celite bed/Silica bed. The crude product was purified on silica gel a column chromatography to afford the corresponding spiro and cyclic quinazolinones 3a-3n, 4a-4h, and 5a, 5b in very good yields except compounds 6a and 7a were obtained in poor yields (Eluent: n-Hexane /EtOAc). All the compounds 3a-3n, 4a-4h, 5a-b, 6a and 7a were thoroughly characterized by 1H NMR, 13CNMR, FTIR and HRMS.
70% With tris(pentafluorophenyl)borate In dimethyl sulfoxide at 100 - 120℃; for 23h; General procedure for the synthesis of 2-phenyl-2,3-dihydroquinazolin-4(1H)-one(3a): General procedure: A mixture of 2-aminobenzamide (1) (0.136 mg, 1 mmol), B(C6H5)3 (20 mol %),and benzaldehyde (2a) (0.60 mg, 5 mmol) in DMSO (24 mL) was heated at 100120 C for 1624 h in a sealed tube. After cooling, the reaction mixture waspoured into water and extracted with EtOAc. The organic layer was washed with brine,dried over MgSO4, and concentrated in vacuum. The residue was purified by flash columnchromatography (silica gel, hexanes/EtOAc) to give desired product.
65% With Amberlyst-15 In acetonitrile at 20℃; for 1.5h;
53% With tin(ll) chloride In ethanol at 120℃; for 0.333333h; Microwave irradiation; Green chemistry; 2-Phenyl-2,3-dihydroquinazolin-4(1H)-one (10a) General procedure: To a microwave vial containing 2-aminobenzamide (8; 226 mg,1.66 mmol), benzaldehyde (9a; 0.17mL, 1.73 mmol, 1.1 equiv.) and tin(II) chloride (3 mg, 0.015 mmol, 0.01 equiv.) were added and stirred in ethanol (3mL) to form a suspension. The microwave vial was then irradiated at 120°C for 20 min. The resultant precipitate was then collected by filtration and washed with minimal H2O (or diethyl ether), affording 2-phenyl-2,3-dihydroquinazolin-4(1H)-one as a white crystalline solid (298 mg, 80%).
47% With Amberlyst-15 In acetonitrile at 20℃; for 12h;
89 % With alginic acid In water at 20℃; Green chemistry; General procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones General procedure: A mixture of anthranilamide (1 mmol), aldehyde/ketone (1 mmol), and alginic acid(5 mg) in water (5 mL) was stirred at room temperature. Reaction progress wasmonitored by TLC (ethyl acetate: n-hexane, 1:9). After completion of the reaction,0.1 N NaOH (5 mL) was added to the reaction mixture to separate alginic acid assodium alginate. The resultant solid product was collected by simple filtration andwashed with water (5 mL). This crude product was recrystallized by using ethanol.
53 % With tin(ll) chloride In ethanol at 120℃; Microwave irradiation;

References: [1]Ramesh; Karnakar; Satish; Anil Kumar; Nageswar [Tetrahedron Letters, 2012, vol. 53, # 51, p. 6936 - 6939].
[2]Novanna, Motakatla; Kannadasan, Sathananthan; Shanmugam, Ponnusamy [Tetrahedron Letters, 2019, vol. 60, # 2, p. 201 - 206].
[3]Shinde, Achut R.; Mane, Yogesh D.; Muley, Dnyanoba B. [Synthetic Communications, 2020, vol. 50, # 1, p. 33 - 40].
[4]Bharate, Sandip B.; Mupparapu, Nagaraju; Manda, Sudhakar; Bharate, Jaideep B.; Mudududdla, Ramesh; Yadav, Rammohan R.; Vishwakarma, Ram A. [ARKIVOC, 2012, vol. 2012, # 8, p. 308 - 318].
[5]O'brien, Nicholas S.; McCluskey, Adam [Australian Journal of Chemistry, 2020, vol. 73, # 12, p. 1176 - 1186].
[6]Bharate, Sandip B.; Yadav, Rammohan R.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa R.; Khan, Ikhlas A.; Vishwakarma, Ram A. [MedChemComm, 2013, vol. 4, # 6, p. 1042 - 1048].
[7]Rajmane, Archana; Jadhav, Dipti; Bagade, Kiran; Patil, Suresh; Kumbhar, Arjun [Research on Chemical Intermediates, 2023, vol. 49, # 12, p. 5237 - 5253].
[8]O'Brien, Nicholas S.; Gilbert, Jayne; McCluskey, Adam; Sakoff, Jennette A. [RSC Medicinal Chemistry, 2024, vol. 15, # 5, p. 1686 - 1708].
  • 15
  • [ 124-13-0 ]
  • [ 88-68-6 ]
  • [ 1352945-74-4 ]
YieldReaction ConditionsOperation in experiment
83% With tert.-butylhydroperoxide In water at 110℃; for 16h; Green chemistry;
83% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
76% With N,N-dimethyl acetamide; sodium hydrogensulfite at 150℃; for 2h;
76% With sodium hydrogensulfite In N,N-dimethyl acetamide for 2h; Reflux;
84 % With oxygen; safranin O; toluene-4-sulfonic acid In methanol; dimethyl sulfoxide at 20℃; Irradiation;
81 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;
67 % With sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃;

References: [1]Sharif, Muhammad; Opalach, Julita; Langer, Peter; Beller, Matthias; Wu, Xiao-Feng [RSC Advances, 2014, vol. 4, # 1, p. 8 - 17].
[2]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[3]Reen, F. Jerry; Clarke, Sarah L.; Legendre, Claire; McSweeney, Christina M.; Eccles, Kevin S.; Lawrence, Simon E.; O'Gara, Fergal; McGlacken, Gerard P. [Organic and Biomolecular Chemistry, 2012, vol. 10, # 44, p. 8903 - 8910].
[4]Reen, F. Jerry; Phelan, John P.; Gallagher, Lorna; Woods, David F.; Shanahan, Rachel M.; Cano, Rafael; Muimhneacháin, Eoin Ó; McGlacken, Gerard P.; O'Gara, Fergal [Antimicrobial Agents and Chemotherapy, 2016, vol. 60, # 10, p. 5894 - 5905].
[5]Liu, Cheng-Hang; Wang, Jun-Jie; Xu, Mengyang; Luo, Qiyun; Wang, Ziyan; Tan, Wenyue; Zhao, Xingzeng; Jia, Xiaodong [New Journal of Chemistry, 2024, vol. 48, # 6, p. 2367 - 2370].
[6]Hu, Yongke; Tian, Hongyou; Cao, Haotian; Li, Jin; Li, Shaozhong; Li, Huaju; Li, Yanxing; Shen, Gulou; Chen, Lei [Molecular catalysis, 2024, vol. 566].
[7]Alatawneh, Nadeem; Thangaraj, Manikandan; Meijler, Michael M. [Chemical Communications, 2024, vol. 60, # 86, p. 12533 - 12536].
  • 16
  • [ 124-38-9 ]
  • [ 88-68-6 ]
  • [ 491-36-1 ]
YieldReaction ConditionsOperation in experiment
71% Stage #1: carbon dioxide With 1,2-Bis(diphenylphosphino)benzene; copper diacetate In 1,4-dioxane at 65℃; for 0.5h; Schlenk technique; Stage #2: anthranilic acid amide With copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 120℃; for 24h; Schlenk technique;
68% With dimethylamine borane In water at 100℃; for 24h; Heating; Green chemistry; 2.2 Experimental Procedure for the Synthesis of Benzimidazoles General procedure: Synthesis of benzimidazole from o-phenylenediamine byCO2and DMAB in presence of Cu(at)U-g-C3N4 was carriedout in high pressure reactor equipped with an overheadstirrer. In a general experiment for the synthesis ofbenzimidazole, o-phenylenediamine (1.00mmol), DMAB(3mmol), PC:H2O (3 mL:1.5mL), Cu(at)U-g-C3N4 (20mg)were loaded into the reactor at room temperature, reactorwas sealed, flushed three times with CO2and 2.5MPa CO2pressure was loaded in to reactor, heated to required temperaturewith stirring (600rpm). After completion of thereaction, the reactor was cooled to room temperature andthe pressure was slowly released. The catalyst was separatedby fltration, washed with ethyl acetate and water.The combined mixture was concentrated in vacuo and theproducts were purified by the column chromatographywith silica gel of 100-200 mesh size and petroleum etherethylacetate used as an eluent to aford pure products The spectroscopic data of all the products werematching with those reported in the literature.
65% With 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene at 70℃; for 24h;
With 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride In tetrahydrofuran at 70℃; for 24h; Schlenk technique; Inert atmosphere; Glovebox; 1.B B-Synthesis of 4-Quinazolinone Derivatives from Functionalized Aromatic Amines B-Synthesis of 4-Quinazolinone Derivatives from Functionalized Aromatic AminesThe following results describe the synthesis of 4-quinazolinone derivatives from aromatic amines functionalized in ortho position by amides (anthranilamides). In this case, the amine R1NH2 and the nitrogenous nucleophile R5R6NH (in this case an amide) are two reactive functional groups of one and the same molecule (diamine) and are thus connected via a covalent bond. This bond is preferably an aromatic ring of benzene, pyridine or pyrimidine type and the ring formed during the reaction is a nitrogenous heterocycle comprising 6 atoms. The results presented in table 2 were obtained by preferably using polymethylhydrosiloxane (PMHS) as reducing agent, the latter proving to be more effective with regard to these reactants than phenylsilane (PhSiH3).
34 % With Triethoxysilane; 1-aminoguanidine hydrochloride; sodium t-butanolate In dimethyl sulfoxide at 100℃; Schlenk technique;
27 %Spectr. With hydrogen; C20H33F6NO4S2Sn at 180℃; Autoclave;

References: [1]Nan, Jiang; Zhang, Lu; Cao, Rui; Zhu, Lanxin; Chen, Gaoyang; Yan, Qiang [Journal of Organic Chemistry, 2025, vol. 90, # 12, p. 4277 - 4290].
[2]Phatake, Vishal V.; Bhanage, Bhalchandra M. [Catalysis Letters, 2019, vol. 149, # 1, p. 347 - 359].
[3]Jacquet, Olivier; DasNevesGomes, Christophe; Ephritikhine, Michel; Cantat, Thibault [ChemCatChem, 2013, vol. 5, # 1, p. 117 - 120].
[4]Current Patent Assignee: C E A - US2015/148535, 2015, A1 Location in patent: Paragraph 0195; 0196.
[5]Sun, Yulin; Gao, Ke [Journal of Organic Chemistry, 2023, vol. 88, # 11, p. 7463 - 7468].
[6]Paparakis, Alexandros; Hulla, Martin [ChemCatChem, 2023, vol. 15, # 12].
  • 17
  • [ 455-19-6 ]
  • [ 88-68-6 ]
  • [ 83800-83-3 ]
YieldReaction ConditionsOperation in experiment
93% In dimethyl sulfoxide at 120℃; for 48h; Inert atmosphere;
86% With toluene-4-sulfonic acid; fluorescein free acid In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
82% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
82% With dihydrogen peroxide In tetrahydrofuran; water at 100℃; for 12h;
78% With bismuth (III) nitrate pentahydrate In ethanol at 60℃; for 12h; General experimental procedure for oxidative cyclocondensation of 2-aminobenzamidewith aldehydes General procedure: To a 100 mL round bottom flask fitted with a condenser containing magnetic stir bar, 1a (0.5mmol), 2a (1.2 equiv, 0.6 mmol), Bi(NO2)3• 5H2O (10 mol%), and ethanol (5 mL) were added.The resultant mixture was stirred at 60 °C under open-air condition for 12 h. The reactionmixture was cooled to rt, and subjected to crystallization (EtOH) to get analytically pure 2-phenyl-3H-quinazolin-4-one 3a (91%); 1H NMR (400 MHz, DMSO-d6) δ 12.55 (s, 1H), 8.28 - 8.10(m, 3H), 7.83 (ddd, J = 8.5, 6.4, 1.7 Hz, 1H), 7.75 (d, J = 8.2 Hz, 1H), 7.67 - 7.47 (m, 4H); 13C NMR(100 MHz, DMSO-d6) δ 162.7, 152.8, 149.2, 135.0, 133.2, 131.8, 129.1, 128.2, 127.9, 127.0,126.3, 121.4; Mass (ESI) m/z: = 222.1(M+).
77% With tert.-butylhydroperoxide In water at 110℃; for 16h; Green chemistry;
77% In dimethyl sulfoxide at 100℃;
76% With iodine; oxygen In ethyl acetate for 15h; Irradiation;
73.2% With bismuth (III) nitrate pentahydrate In ethanol at 90℃; for 12h; 5.A The specific procedure involved placing the compounds (544.6 mg, 4 mmol) and (835.8 mg, 4.8 mmol) into a three-necked flask. 100 ml of ethanol was added to dissolve the compounds, followed by the addition of bismuth nitrate pentahydrate (194.03 mg, 0.4 mmol). The mixture was then heated to 90 and reacted at this temperature for 12 hours. The reaction was monitored by thin-layer chromatography (TLC). After the reaction was complete, the reaction mixture was concentrated to a slurry using a rotary evaporator, filtered, and dried in a freeze-dryer to obtain the compound.The compound was a white powder with a yield of 73.2%
45% With boron trifluoride diethyl etherate; potassium <i>tert</i>-butylate In 1,4-dioxane at 130℃; for 24h; Heating; Inert atmosphere; General procedure for the synthesis of 3-Methyl-2-phenylquinazolin-4(3H)-one (3a) General procedure: To a 25 mL round-bottom flask were added 2-iodo-N-methylbenzamide 1a (130.5 mg, 0.5 mmol), Benzonitrile (206 mg, 2.0 mmol), KOtBu (168 mg, 1.5 mmol) and BF3.OEt2 (35.2 mg, 0.25 mmol) in 3.0 mL of 1, 4-dioxane. The reaction mixture was heated in an oil bath at 130 °C for 24 hrs. After completion of the reaction; it was allowed to attain room temperature. The reaction mixture was quenched by saturated NaHCO3 (20 ml, PH= 10.3) solution and extracted by ethyl acetate (15 mL x 3) dried over anhydrous Na2SO4, and the solvent was removed under reduced pressure the residue was purified by column chromatography using silica gel (30% EtOAc/hexane) to afford 3a (83.1 mg; 70% yield).
4% In dimethyl sulfoxide at 100℃;
Multi-step reaction with 2 steps 1: water / 2 h / Reflux 2: C5H11IrO3(2+)*2CF3O3S(1-) / water / 1 h / Reflux
In dimethyl sulfoxide at 110℃;
With iodine In ethanol Schlenk technique; Inert atmosphere; Reflux; 2.1 Preparation of 2-aryl quinazolin-4(3H)-ones (Substrates 1) General procedure: A stirred mixture of anthranilamide (0.5 mmol) and aldehyde (0.6 mmol) in ethanol (5 mL) was treated with iodine (0.55 mmol), and then heated to reflux until the starting material disappeared (monitored by TLC, 1-6 h). After cooling to room temperature, the reaction mixture was quenched with 5% Na2S2O3 aqueous (1 mL), and concentrated to remove most of the solvent. The resulting residue was redissolved in ethyl acetate (15 mL), followed by the addition of brine (15 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (15 mL × 2). The combined organic layer was dried over anhydrous Na2SO4, concentrated, and purified through silica gel column chromatography using a mixture of ethyl acetate (EtOAc) and petroleum ether (PE) as eluent to afford the corresponding quinazolinone (0.067g, 99%).
With oxygen In dimethyl sulfoxide at 120℃; for 24h;
With oxygen In dimethyl sulfoxide at 120℃; for 24h; Sealed tube;
In dimethyl sulfoxide at 120℃; for 48h;
With tert.-butylhydroperoxide In dichloromethane; water at 60℃; Inert atmosphere; Schlenk technique;
83 % With 4CzIPN; oxygen In dimethyl sulfoxide at 20℃; Molecular sieve; Irradiation;
72 % In dimethyl sulfoxide at 95 - 110℃; 2.2. General Procedure for the Synthesis of Compounds General procedure: A mixture of 2-aminobenzamide (1 eq.), aldehydes (1.1"q.) and dimethyl &lfo>id" (DSO) (5 "q.) wa add"d tothe 10 ml RBF (Round Bottom Flask). The reaction mixturewas stirred on the magnetic stirrer for 24 h at 95- 110 0C.Reaction progress was checked using pre-coated MerckSilica g"l TLC plat" and p"trol"&m "t"r: ethyl acetate (`:3)as mobile phase. Water was added to the resultant mixtureafter completion of the reaction to achieve the desiredpr"cipitat". S&?"q"ntly, it wa tr"at"d wit ethyl acetate(10 mL x 3) and cleaned with water and brine solution. Theorganic sample was washed over anhydrous Na2SO4 andfiltered through column chromatography (EtOAc: Pet ether,2:8). Compounds have been recrystallized in a mixture ofmethanol/ethanol and dichloromethane (DCM) [32].
With air In dimethyl sulfoxide at 120℃; for 24h;

References: [1]Rohokale, Rajendra S.; Kalshetti, Rupali G.; Ramana, Chepuri V. [Journal of Organic Chemistry, 2019, vol. 84, # 5, p. 2951 - 2961].
[2]Wang, Rongzhou; Liu, Shiyuan; Li, Longfei; Song, Ao; Yu, Shengsheng; Zhuo, Shuping; Xing, Ling-Bao [Molecular catalysis, 2021, vol. 509].
[3]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[4]Ma, Zhiming; Song, Tao; Yuan, Youzhu; Yang, Yong [Chemical Science, 2019, vol. 10, # 44, p. 10283 - 10289].
[5]Vemula, Sandeep R.; Kumar, Dinesh; Cook, Gregory R. [Tetrahedron Letters, 2018, vol. 59, # 42, p. 3801 - 3805].
[6]Sharif, Muhammad; Opalach, Julita; Langer, Peter; Beller, Matthias; Wu, Xiao-Feng [RSC Advances, 2014, vol. 4, # 1, p. 8 - 17].
[7]Kim, Saegun; Jeoung, Daeun; Kim, Kunyoung; Lee, Seok Beom; Lee, Suk Hun; Park, Min Seo; Ghosh, Prithwish; Mishra, Neeraj Kumar; Hong, Suckchang; Kim, In Su [European Journal of Organic Chemistry, 2020, vol. 2020, # 46, p. 7134 - 7143].
[8]Nagasawa; Matsusaki; Nobuta; Tada; Miura; Itoh [RSC Advances, 2015, vol. 5, # 78, p. 63952 - 63954].
[9]Current Patent Assignee: UNIV GUANGXI NATIONALITIES - CN121159502, 2025, A Location in patent: Paragraph 0041-0043; 0045-0047; 0049-0051.
[10]Nomula, Vishnuvardhan; Rao, Sadu Nageswara [Synthetic Communications, 2021, vol. 51, # 17, p. 2602 - 2612].
[11]Maiti, Saikat; Kim, Jaeshin; Park, Jae-Heon; Nam, Dongsik; Lee, Jae Bin; Kim, Ye-Jin; Kee, Jung-Min; Seo, Jeong Kon; Myung, Kyungjae; Rohde, Jan-Uwe; Choe, Wonyoung; Kwon, Oh-Hoon; Hong, Sung You [Journal of Organic Chemistry, 2019, vol. 84, # 11, p. 6737 - 6751].
[12]Current Patent Assignee: NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY - CN106518789, 2017, A.
[13]Fan, Zhijiang; Shi, Jun; Luo, Na; Ding, Muhan; Bao, Xiaoping [Journal of Agricultural and Food Chemistry, 2019, vol. 67, # 42, p. 11598 - 11606].
[14]Wang, Chang; Qian, Peng-Cheng; Chen, Fan; Cheng, Jiang [Tetrahedron Letters, 2020, vol. 61, # 43].
[15]Liu, Xuexin; Chen, Jian; Yang, Chunyan; Wu, Zhouping; Li, Zhiyang; Shi, Yuesen; Huang, Tianle; Yang, Zhongzhen; Wu, Yong [Organic Letters, 2021, vol. 23, # 17, p. 6831 - 6835].
[16]Chen, Yuncan; Huang, Xin; Xu, Yingying; Li, Jianglian; Lai, Ruizhi; Guan, Mei; Wu, Yong [Synlett, 2021, vol. 32, # 19, p. 1963 - 1968].
[17]Kang, Shaodong; Li, Jiaxing; Yang, Qin; Song, Zhibin; Peng, Yiyuan [European Journal of Organic Chemistry, 2022, vol. 2022, # 30].
[18]Shen, Qi; Sheng, Kai; Gao, Zhi-Yong; Bilyachenko, Alexey; Huang, Xian-Qiang; Azam, Mohammad; Tung, Chen-Ho; Sun, Di [Inorganic Chemistry, 2024, vol. 63, # 28, p. 13022 - 13030].
[19]Hu, Yongke; Tian, Hongyou; Cao, Haotian; Li, Jin; Li, Shaozhong; Li, Huaju; Li, Yanxing; Shen, Gulou; Chen, Lei [Molecular catalysis, 2024, vol. 566].
[20]Guleria, Maneesh; Kumar, Adarsh; Singh, Ankit Kumar; Kumar, Pradeep [Combinatorial Chemistry and High Throughput Screening, 2024, vol. 27, # 9, p. 1329 - 1343].
[21]Kirwale, Amol B.; Bhawale, Rajesh T.; Kshirsagar, Umesh A. [European Journal of Organic Chemistry, 2025, vol. 28, # 30].
  • 18
  • [ 88-68-6 ]
  • [ 620-23-5 ]
  • [ 18818-40-1 ]
YieldReaction ConditionsOperation in experiment
95% With dimethyl sulfoxide at 20℃; for 18h; Irradiation; Green chemistry;
93% With iodine; oxygen In ethyl acetate for 10h; Irradiation;
89% With toluene-4-sulfonic acid; fluorescein free acid In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry; General procedure for the synthesis of quinazolinones. General procedure: To anoven-dried 15 mL flat quartz glass jar with a magnetic stirrer were addedo-aminobenzamides (1, 0.2 mmol), aldehydes (2, 0.2 mmol), fluorescein(2 mol%), p-TsOH (10 mol%) and CH3CN (2 mL). The open-air reactioncontainer was placed under 10 W blue LEDs lamp at room temperaturefor 2 h. After completion of the reaction, the reaction mixture wasconcentrated in vacuo and purified by flash column chromatography with hexane/ethyl acetate to afford the corresponding products.
88% With tert.-butylhydroperoxide In acetonitrile at 140℃; for 48h; UV-irradiation; 6 2-(3-methylphenyl)-4(3H)-quinazolinone, its structural formula is: In a 5.0 mL reaction vessel, 0.3 mmol of 3-methylbenzaldehyde, 0.1 mmol of o-aminobenzamide, and 0.2 mmol of tert-butyl hydroperoxide were added, along with 2.0 mL of acetonitrile solvent. Oxygen was then introduced to create a reaction atmosphere. The reaction was then carried out at 140 °C for 48 hours under irradiation with a high-pressure mercury lamp at a maximum wavelength of 365 nm and a power of 250 W. The reaction was then stopped and cooled to room temperature. The reaction solution was diluted with dichloromethane, extracted three times with water, and the organic phase was treated with anhydrous sodium hydroxide.2SO4The product was dried, filtered, and separated by column chromatography to obtain 20.7 mg of the target product, with a yield of 88%.
85% With bis(acetylacetonate)oxovanadium; oxygen In 1,2-dichloro-ethane at 80℃; for 6h; General procedure for the 2-Phenylquinazolin-4(3H)-one (3a) General procedure: A mixture of 2-Aminobenzamides 1a (1 mmol), VO(acac)2 (0.05 mmol) and benzaldehyde 2a (1 mmol) was stirred and heated at 80 ° C for 6 h under O2 atmosphere. After completion of the reaction, the resulting solution was cooled to room temperature, and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (3:1 to 1:1) as the eluent to provide the desired products 3a (198 mg, 89 % yield).
83.1% With copper dichloride In ethanol at 80℃; for 18h; 5.1 (1) Synthesis of 2-(3-methylphenyl)-quinazolin-4(3H)-one: Take 55g of anthranilamide, 50.0g of 3-methylbenzaldehyde, and 95g of CuCl2, add it to 800 mL of ethanol, stir and reflux at 80° C. for 18 h, and detect by TLC (developing solvent is ethyl acetate and petroleum ether in a volume ratio of 1 After the reaction was completed, 700 mL of water was added to continue heating and stirring for 1 h, filtered, and the filter cake was dried at 90 ° C to obtain a white solid 79.3 g, and the solid was 2-(3-methylphenyl)-quinazoline- 4(3H)-ketone, yield 83.1%.
79% With air; mesoporous [SiO2-(CH2)3-DABCO-(CH2)4-SO3H][HSO4] In water at 100℃; for 8h; 2.4. Synthetic route of 2-phenylquinazolin-4(3H)-ones General procedure: To conduct the reaction, benzaldehyde (1.2 mmol, 159 mg) and 2- aminobenzamide (1.0 mmol, 136 mg) were combined in a roundbottom flask along with the [SiO2-(CH2)3-DABCO-(CH2)4-SO3H] [HSO4] catalyst (10 mol%). After adding water (10 mL) as the solvent, the reaction mixture was refluxed at 100 C for 8 h under ambient air conditions. The progress of the reaction was monitored using thin-layer chromatography. After the reaction was completed, the mixture was allowed to cool to room temperature. The resulting white precipitate was then filtered and recrystallized using ethanol, yielding 181 mg (81 %) of a white powder. The catalyst was separated by centrifuge, washed further with a small quantity of anhydrous ethanol (3 × 3.0 mL), and dried at 80 C for 60 min for the subsequent experiments. The derivatives of 2-arylquinazolin-4(3H)-one were isolated by a similar procedure starting from aromatic benzaldehydes. The structure of products was confirmed by 1 H NMR, 13C NMR, and MS.
71% With acetic acid at 25℃; Irradiation;
In dimethyl sulfoxide at 110℃;
With iodine In ethanol Schlenk technique; Inert atmosphere; Reflux; 2.1 Preparation of 2-aryl quinazolin-4(3H)-ones (Substrates 1) General procedure: A stirred mixture of anthranilamide (0.5 mmol) and aldehyde (0.6 mmol) in ethanol (5 mL) was treated with iodine (0.55 mmol), and then heated to reflux until the starting material disappeared (monitored by TLC, 1-6 h). After cooling to room temperature, the reaction mixture was quenched with 5% Na2S2O3 aqueous (1 mL), and concentrated to remove most of the solvent. The resulting residue was redissolved in ethyl acetate (15 mL), followed by the addition of brine (15 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (15 mL × 2). The combined organic layer was dried over anhydrous Na2SO4, concentrated, and purified through silica gel column chromatography using a mixture of ethyl acetate (EtOAc) and petroleum ether (PE) as eluent to afford the corresponding quinazolinone (0.067g, 99%).
With oxygen In dimethyl sulfoxide at 120℃; for 24h; Sealed tube;
In dimethyl sulfoxide at 120℃; for 48h;
88% With fluorescein In methanol at 20℃; Irradiation; Quinazolinones General procedure: A mixture of 2-aminobenzamide (0.2 mmol),benzaldehyde (0.6 mmol), fluorescein (3 mol%) and methanol (2 mL)was added to the test tube. The reaction mixture was irradiated with aBlue LED (18 W) for 1-2 h under air atmosphere and stirred at 300-400rpm.
61 % With iodine In ethanol at 80℃; Sealed tube; Green chemistry;
With tert.-butylhydroperoxide In dichloromethane; water at 60℃; Inert atmosphere; Schlenk technique;
With biphenyl; oxygen; Zn4 (4,4'-azobispyridine)8 (V2O7)4.H2O In acetonitrile at 90℃; for 2h;

References: [1]Yang, Jiangnan; Xie, Zongbo; Chen, Zhongsheng; Jin, Liang; Li, Qian; Le, Zhanggao [Journal of Heterocyclic Chemistry, 2021, vol. 58, # 7, p. 1496 - 1501].
[2]Nagasawa; Matsusaki; Nobuta; Tada; Miura; Itoh [RSC Advances, 2015, vol. 5, # 78, p. 63952 - 63954].
[3]Wang, Rongzhou; Liu, Shiyuan; Li, Longfei; Song, Ao; Yu, Shengsheng; Zhuo, Shuping; Xing, Ling-Bao [Molecular catalysis, 2021, vol. 509].
[4]Current Patent Assignee: XIAMEN MEDICAL COLLEGE - CN120365219, 2025, A Location in patent: Paragraph 0044-0047.
[5]Bie, Zhixing; Li, Guosong; Wang, Lianyue; Lv, Ying; Niu, Jingyang; Gao, Shuang [Tetrahedron Letters, 2016, vol. 57, # 44, p. 4935 - 4938].
[6]Current Patent Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY - CN114591251, 2022, A Location in patent: Paragraph 0116-0118.
[7]Nguyen, The Thai; Wu, Jhao-Yang; Tsai, Yi-Chou; Tran, Phuong Hoang [Journal of Molecular Liquids, 2025, vol. 433].
[8]Wang, Jian; Gong, Tiancheng; Zhuang, Zirui; Sun, Bing; Zhang, Fang-Lin [Organic and Biomolecular Chemistry, 2025, vol. 23, # 18, p. 4371 - 4375].
[9]Fan, Zhijiang; Shi, Jun; Luo, Na; Ding, Muhan; Bao, Xiaoping [Journal of Agricultural and Food Chemistry, 2019, vol. 67, # 42, p. 11598 - 11606].
[10]Wang, Chang; Qian, Peng-Cheng; Chen, Fan; Cheng, Jiang [Tetrahedron Letters, 2020, vol. 61, # 43].
[11]Chen, Yuncan; Huang, Xin; Xu, Yingying; Li, Jianglian; Lai, Ruizhi; Guan, Mei; Wu, Yong [Synlett, 2021, vol. 32, # 19, p. 1963 - 1968].
[12]Kang, Shaodong; Li, Jiaxing; Yang, Qin; Song, Zhibin; Peng, Yiyuan [European Journal of Organic Chemistry, 2022, vol. 2022, # 30].
[13]Jin, Liang; Chen, Xuehua; Huang, Sheng; Wang, Aixin; Chen, Zhongsheng; Le, Zhanggao; Xie, Zongbo [Molecular catalysis, 2023, vol. 547].
[14]Kerdphon, Sutthichat; Khamto, Nopawit; Buddhachat, Kittisak; Ngoenkam, Jatuporn; Paensuwan, Pussadee; Pongcharoen, Sutatip; Singh, Thishana; Meepowpan, Puttinan; Jongcharoenkamol, Jira [ACS Medicinal Chemistry Letters, 2023, vol. 14, # 9, p. 1167 - 1173].
[15]Shen, Qi; Sheng, Kai; Gao, Zhi-Yong; Bilyachenko, Alexey; Huang, Xian-Qiang; Azam, Mohammad; Tung, Chen-Ho; Sun, Di [Inorganic Chemistry, 2024, vol. 63, # 28, p. 13022 - 13030].
[16]Zhu, Maochun; Bai, Xue; Yang, Yanli; Zhang, Ange; Wang, Siyue; Sun, Chengyu; Lu, Ying; Li, Bin; Liu, Shuxia [Green Chemistry, 2025, vol. 27, # 48, p. 15753 - 15765].
  • 19
  • [ 70289-12-2 ]
  • [ 88-68-6 ]
  • [ 64055-53-4 ]
YieldReaction ConditionsOperation in experiment
69% With dipotassium peroxodisulfate In water at 80℃; Sealed tube;
References: [1]Laha, Joydev K.; Gulati, Upma; Saima; Gupta, Anjali; Indurthi, Harish Kumar [New Journal of Chemistry, 2021, vol. 45, # 5, p. 2643 - 2648].
 

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• Acyl Group Substitution • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Friedel-Crafts Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Alkylbenzene • Preparation of Amines • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction • Vilsmeier-Haack Reaction

Categories

Chemistry
Organic Building Blocks
Amides
2-Aminobenzamide
Chemistry
Organic Building Blocks
Amines
2-Aminobenzamide
Chemistry
Organic Building Blocks
Aryls
Chemistry
Organic Building Blocks
Benzene Compounds

Tags: 88-68-6 | Anthranilamide | Aryls | Amides | Amines | Benzene Compounds | Organic Building Blocks

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