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Type | HazMat fee for 500 gram (Estimated) |
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Synonyms: Decanoic acid chloride
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 112-13-0 |
Formula : | C10H19ClO |
M.W : | 190.71 |
SMILES Code : | CCCCCCCCCC(Cl)=O |
Synonyms : |
Decanoic acid chloride
|
MDL No. : | MFCD00000771 |
InChI Key : | IPIVAXLHTVNRBS-UHFFFAOYSA-N |
Pubchem ID : | 66982 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P280-P305+P351+P338-P310 |
Class: | 8 |
UN#: | 3265 |
Packing Group: | Ⅱ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; dmap; In dichloromethane; at 20℃; | General procedure: Into a round-bottom flask were added 5.71mmolof alditolyl-triazole 12 or 21a in 50ml dichloromethane, 0.9mL of pyridine (2 eq.), 5.71mmolof acyl chloride and catalytic amount of DMAP. The mixture was stirred vigorously at room temperature, and the reaction progress was monitored by thin layer chromatography. Next, the mixture was washed with distilled water (3×100mL), saturated sodium bicarbonate solution (5×100mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The product was purified via silica-gel column chromatography using gradient mixture of hexane-ethyl acetate, to afford the pure derivatives 13a-k and 22a-d. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30.83 g | In tetrahydrofuran; for 3h; | 34.4 g (0.2 mol) of decanoic acid, 17.85 g (0.15 mol) of thionyl chloride was added, Mixed hook at 60 C for 3 hours, 20 ml of a tetrahydrofuran solution containing 15.4 g (0 lmo 1) alpha-<strong>[98-55-5]terpineol</strong> was added, Continue to react for 3 hours, The reaction solution was adjusted to pH 6-7 with NaOH solution. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated brine and dried over Na2S04 overnight. The solvent was evaporated and the column chromatography For 200 to 300 mesh), B petroleum ether and ethyl acetate (15: 1) as the eluent, and the eluent was distilled off to give 30.83 g of a colorless liquid, The yield was 93.5%. |