Fmoc-Lys(Mmt)-OH | Amines

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Quality Control of Fmoc-Lys(Mmt)-OH Purity: 95% SDS Specification

COA

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NMR

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CNMR

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HPLC

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LC-MS

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Product Details of Fmoc-Lys(Mmt)-OH

CAS No. :	159857-60-0
Formula :	C₄₁H₄₀N₂O₅
M.W :	640.77
SMILES Code :	O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CCCCNC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6
MDL No. :	MFCD00270542
InChI Key :	CTYHQVFFQRDJSN-LHEWISCISA-N
Pubchem ID :	11422318

Safety of Fmoc-Lys(Mmt)-OH

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Application In Synthesis of Fmoc-Lys(Mmt)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 159857-60-0 ]

[ 159857-60-0 ] Synthesis Path-Downstream 1~8

1
[ 29022-11-5 ]
[ 35661-60-0 ]
[ 35661-39-3 ]
Palm-γGlu-γGlu-OSu [ No CAS ]
[ 71989-31-6 ]
[ 35661-40-6 ]
[ 71989-33-8 ]
[ 71989-14-5 ]
[ 71989-18-9 ]
[ 71989-23-6 ]
[ 71989-26-9 ]
[ 71989-35-0 ]
[ 35661-38-2 ]
[ 132327-80-1 ]
[ 109425-51-6 ]
[ 94744-50-0 ]
[ 32926-43-5 ]
[ 143824-78-6 ]
[ 159857-60-0 ]
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ]
H-Aib-Q-G-T-F-T-S-D-L-S-K-L-K[gGlu-gGlu-Palm]-E-E-Q-R-Q-Aib-E-F-I-E-W-L-K-A-dAla-G-H-P-S-Aib-K-P-P-P-K-NH₂; Aib=alpha-amino-isobutyric acid, gGlu=gamma-glutamate, Palm=palmitoyl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		The solid phase synthesis as described in Methods was carried out on Novabiochem Rink-Amide resin (4-(2?,4?-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucylaminomethyl resin), 100-200 mesh, loading of 0.43 mmol/g. The Fmoc-synthesis strategy was applied with HBTU/DIPEA-activation. In position 14 Fmoc-Lys(Mmt)-OH and in position 1 Boc-His(Trt)-OH were used in the solid phase synthesis protocol. The Mmt-group was cleaved from the peptide on resin as described in the Methods. Hereafter Palm-gGlu-gGlu-OSu was coupled to the liberated amino-group employing DIPEA as base. The peptide was cleaved from the resin with King's cocktail (D. S. King, C. G. Fields, G. B. Fields, Int. J. Peptide Protein Res. 1990, 36, 255-266). The crude product was purified via preparative HPLC on a Waters column (Sunfire Prep C18 OBD 5 mum 50×150 mm) using an acetonitrile/water gradient (both buffers with 0.1percent TFA). The purified peptide was analysed by LCMS (Method B). (0376) Deconvolution of the mass signals found under the peak with retention time 9.828 min revealed the peptide mass 4894.63 which is in line with the expected value of 4894.64.

References: [1]Patent: US2018/155407,2018,A1 .Location in patent: Paragraph 0280-0281; 0283-0286; 0375-0376.

2
[ 29022-11-5 ]
[ 35661-60-0 ]
[ 35661-39-3 ]
Palm-γGlu-γGlu-OSu [ No CAS ]
[ 71989-31-6 ]
[ 35661-40-6 ]
[ 71989-33-8 ]
[ 71989-14-5 ]
[ 71989-18-9 ]
[ 71989-23-6 ]
[ 71989-26-9 ]
[ 71989-35-0 ]
[ 35661-38-2 ]
[ 132327-80-1 ]
[ 109425-51-6 ]
[ 94744-50-0 ]
[ 32926-43-5 ]
[ 143824-78-6 ]
[ 159857-60-0 ]
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine [ No CAS ]
H-Aib-Q-G-T-F-T-S-D-L-S-K-L-K[gGlu-gGlu-Palm]-E-K-Q-R-Q-Aib-E-F-I-E-W-L-K-A-dAla-G-H-P-S-Aib-K-P-P-P-K-NH₂; Aib=alpha-amino-isobutyric acid, gGlu=gamma-glutamate, Palm=palmitoyl [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		The solid phase synthesis as described in Methods was carried out on Novabiochem Rink-Amide resin (4-(2?,4?-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucylaminomethyl resin), 100-200 mesh, loading of 0.43 mmol/g. The Fmoc-synthesis strategy was applied with HBTU/DIPEA-activation. In position 14 Fmoc-Lys(Mmt)-OH and in position 1 Boc-His(Trt)-OH were used in the solid phase synthesis protocol. The Mmt-group was cleaved from the peptide on resin as described in the Methods. Hereafter Palm-gGlu-gGlu-OSu was coupled to the liberated amino-group employing DIPEA as base. The peptide was cleaved from the resin with King's cocktail (D. S. King, C. G. Fields, G. B. Fields, Int. J. Peptide Protein Res. 1990, 36, 255-266). The crude product was purified via preparative HPLC on a Waters column (Sunfire Prep C18 OBD 5 mum 50×150 mm) using an acetonitrile/water gradient (both buffers with 0.1percent TFA). The purified peptide was analysed by LCMS (Method B). (0376) Deconvolution of the mass signals found under the peak with retention time 9.828 min revealed the peptide mass 4894.63 which is in line with the expected value of 4894.64. In an analogous way, the other peptides listed in Table 3 were synthesized and characterized.