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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 4730-54-5 Chemical Structure| 4730-54-5
Chemical Structure| 4730-54-5

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Synonyms: 1,4,7-Triazacyclononane

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Citations

Product Citations

Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing ; Gordon, Akiva ; Jiang, Allen ; Varley, Andrew , et al.

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

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Product Details of 1,4,7-Triazonane

CAS No. :4730-54-5
Formula : C6H15N3
M.W : 129.20
SMILES Code : N1CCNCCNCC1
Synonyms :
1,4,7-Triazacyclononane
MDL No. :MFCD00012358
InChI Key :ITWBWJFEJCHKSN-UHFFFAOYSA-N
Pubchem ID :188318

Safety of 1,4,7-Triazonane

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:3259
Packing Group:

Application In Synthesis of 1,4,7-Triazonane

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4730-54-5 ]

[ 4730-54-5 ] Synthesis Path-Downstream   1~6

  • 2
  • [ 50-00-0 ]
  • [ 13395-85-2 ]
  • [ 4730-54-5 ]
  • 1,4,7-tris(3-tert-butyl-5-chloro-2-hydroxybenzyl)-1,4,7-triazacyclononane [ No CAS ]
  • 3
  • [ 50-00-0 ]
  • [ 6683-81-4 ]
  • [ 4730-54-5 ]
  • 1,4,7-tris(3-tert-butyl-2-hydroxy-5-nitrobenzyl)-1,4,7-triazacyclononane [ No CAS ]
  • 4
  • [ 50-00-0 ]
  • [ 10323-39-4 ]
  • [ 4730-54-5 ]
  • 1,4,7-tris(5-bromo-3-tert-butyl-2-hydroxybenzyl)-1,4,7-triazacyclononane [ No CAS ]
  • 5
  • [ 67-66-3 ]
  • [ 27311-65-5 ]
  • [ 4730-54-5 ]
  • N,N′,N″-Tris(1-isoquinolylmethyl)-1,4,7-triazacyclononane*0.4CHCl3 [ No CAS ]
  • 6
  • [ 6608-47-5 ]
  • [ 4730-54-5 ]
  • 1,4,7-tris(vinylsulfonyl)-1,4,7-triazonane [ No CAS ]
YieldReaction ConditionsOperation in experiment
9.31% With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25℃;Cooling with ice; To a solution of 1,4,7-triazonane (1.00 g, 7.74 mmol) in DCM (30 mL) was added DIEA (3.00 g, 23.2 mmol, 4.04 mL) in an ice-bath (0 C.) and followed by addition of <strong>[6608-47-5]ethenesulfonyl chloride</strong> (2.94 g, 23.2 mmol, 2.28 mL). Then the mixture was warmed slowly to 25 C. and stirred for 4 hr. LC-MS showed starting material was consumed completely and desired mass was detected. The reaction mixture was concentrated under reduced pressure to give a residue. The residue was purified by prep-HPLC (TFA condition) to give the desired product (300 mg, 9.31%) as a white solid. 1H NMR: CDCl3delta 10.79 (s, 1H), 7.27 (s, 2H), 6.49-6.59 (m, 3H), 6.30 (s, 1H), 6.26 (s, 1H), 6.24-6.33 (m, 1H), 6.04-6.09 (m, 1H), 6.05 (s, 1H), 6.03-6.06 (m, 1H), 3.47 (s, 12H) Purity by LC-MS: 95.10%, RT: 1.46
 

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