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Chemical Structure| 506-43-4 Chemical Structure| 506-43-4
Chemical Structure| 506-43-4

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Linoleyl Alcohol is a fatty alcohol and a structural analog of Linoleic acid, commonly used in research and analytical applications.

Synonyms: cis,cis-Octadeca-9,12-dienol; Linoleic Alcohol

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Product Citations

Product Citations      Show More

Xuexiang Han ; Mohamad-Gabriel Alameh ; Ningqiang Gong ; Lulu Xue ; Majed Ghattas ; Goutham Bojja , et al.

Abstract: Lipid nanoparticles (LNPs) are widely used for mRNA delivery, with cationic lipids greatly afecting biodistribution, cellular uptake, endosomal escape and transfection efciency. However, the laborious synthesis of cationic lipids limits the discovery of efcacious candidates and slows down scale-up manufacturing. Here we develop a one-pot, tandem multi-component reaction based on the rationally designed amine-thiol-acrylate conjugation, which enables fast (1 h) and facile room-temperature synthesis of amidine-incorporated degradable (AID) lipids. Structure-activity relationship analysis of a combinatorial library of 100 chemically diverse AID-lipids leads to the identifcation of a tail-like amine-ring-alkyl aniline that generally afords efcacious lipids. Experimental and theoretical studies show that the embedded bulky benzene ring can enhance endosomal escape and mRNA delivery by enabling the lipid to adopt a more conical shape. The lead AID-lipid can not only mediate local delivery of mRNA vaccines and systemic delivery of mRNA therapeutics, but can also alter the tropism of liver-tropic LNPs to selectively deliver gene editors to the lung and mRNA vaccines to the spleen.

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Li, Bowen ; Manan, Rajith Singh ; Liang, Shun-Qing ; Gordon, Akiva ; Jiang, Allen ; Varley, Andrew , et al.

Abstract: The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for mRNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases.

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Product Details of Linoleyl alcohol

CAS No. :506-43-4
Formula : C18H34O
M.W : 266.46
SMILES Code : CCCCC\C=C/C\C=C/CCCCCCCCO
Synonyms :
cis,cis-Octadeca-9,12-dienol; Linoleic Alcohol
MDL No. :MFCD00056667
InChI Key :JXNPEDYJTDQORS-HZJYTTRNSA-N
Pubchem ID :5365682

Safety of Linoleyl alcohol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Linoleyl alcohol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 506-43-4 ]

[ 506-43-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 506-43-4 ]
  • [ 4102-60-7 ]
YieldReaction ConditionsOperation in experiment
80% With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0℃; In a round bottom flask was introduced triphenylphosphine (1.90 g, 7.3 mmol), carbon tetrabromide (2.16 g, 6.5 mmol), and dichloromethane (DCM) (15 mL) was added at 0C, the mixture is let stirred for 10 minutes (orange solution), then (9Z, 12Z)-octadecadien-1-ol (965.9 mg, 3.6 mmol) in DCM (10 mL) was transferred on the mixture via cannula at 0C. A white precipitate was formed. The reaction mixture was let warm up overnight; then it was filtered over celite and concentrated under reduced pressure. The product was purified by a column chromatography on SiO2 (petroleum ether/ ethyl acetate (9:1), Rf = 0.90). mpure = 0.96 g. Aspect: colorless oil. Yield: 80%. 1H NMR (500 MHz, CDCl3) delta (ppm): 5.42-5.34 (m, 4H), 3.43 (t, 2H, J = 6.9 Hz), 2.79 (m, 2H), 2.07 (m, 4H), 1.88 (m, 2H), 1.45 (m, 2H), 1.39-1.31 (m, 14H), 0.92 (t, 3H, J = 7.0 Hz) 13C {1H} NMR (126 MHz, CDCl3) delta (ppm): 130.20, 130.10, 128.01, 63.07, 32.81, 31.52, 29.64, 29.48, 29.39, 29.34, 29.22, 27.20, 25.73, 25.63, 22.55, 14.03. One C is missing. HRMS calcd for C18H32Br [M-H]+ 327.1681, found 327.1682.
66% With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 20℃; To a solution of (9Z, 12Z)-octadeca-9, 12-dien- l -ol (5 g, 1 8.76 mmol) and PPh3 (5.22 g, 19.89 mmol) in DCM (60 mL) at 0 C, was added NBS (3.87 g, 21 .77 mmol) in one portion. The reaction mixture was allowed to stir at 0 C for 1 hour and then allowed to slowly warm to room temperature and allowed to stir for 1 hour. 240 mL of hexanes was added to the reaction mixture, filtered through a silica gel plug and concentrated in vacuo. 200 mL of hexanes was added to the reaction mixture, filtered through a silica gel plug and concentrated in vacuo to afford (6Z,9Z)- 8-bromooctadeca-6,9-diene (4.06 g, 12.33 mmol, 66%). NMR (300 MHz, CDC13) delta: ppm 5.45-5.3 1 (br. m, 4H); 3.43 (t, 2H); 2.80 (m, 2H); 2.1 1 - 2.04 (br. m, 411); 1 .88 (m, 211); 1 .47-1 .33 (br. m, 1 H); 0.92 (m, 3H).
  • 2
  • [ 506-43-4 ]
  • [ 85185-24-6 ]
  • C46H81NO6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% Intermediate 12: Intermediate 11 (2.5 g, 10.11 mmol), EDC (5.8 g, 30.30 mmol), and DMAP (494 mg, 4.04 mmol) in an oven-dried flask (200 mE) with a magnetic bar was added anhydrous DCM (50 mE). The mixture was stirred at ambient temperature for 5 minutes to a clear solution. Einoleyl alcohol (6.5 g, 24.20 mmol) was then added and the mixture was stirred at room temperature overnight. The reaction was finally quenched with H20 (50 mE) and extracted with DCM twice (2x50 mE). Organic layers were combined, dried over MgSO4, and filtered. The filtrate was concentrated under reduced pressure. The crude purified by flash chromatography purification system (80 g silica gel colunm) using a gradient of hexane for 2 mm, then 0-25% EtOAc/hexane for 15 mm, then 25% EtOAc/hexane for 5 mm, then 75% EtOAc/hexane for 5 mm under the flow rate at 60 mE/mm. The product fractions were collected and concentrated to yield Intermediate 12 (7.0 g, 93% yield) as a clear liquid. ?H mm (400 MHz, CDC13) oe: 5.38-5.3 1 (8H, m, CH=), 4.28 (1H, bs, NH), 4.08-4.05 (4H, m, OCH2), 2.78-2.75 (4H, m, rrrCHCH2CHrrr), 2.69-2.59 (4H, m, COCH2N), 2.06-2.02 (4H, m, CH2CH2CH), 1.62-1.58 (4H, m, CH2CH2O), 1.43 (9H, s, C(CH3)3), 1.35-1.26 (36H, m, CH2), 0.90-0.86 (6H, m, CH3).
 

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